Gwenaëlle André

I work as a structural computational biologist at Inrae, on the Campus of Jouy-en-Josas, in MaIAGE: Applied Mathematics and Computer Science, from Genome to Environment. This lab is headed by Dr. B. Laroche, and has a co-sharing divisions of MIA (Applied Mathematics and Informatics) and MICA (Microbiology and Food Chain). I belong to the StatInfoMics team headed by Dr. M. Mariadassou. My principal interest deals with structural and computational bioinformatics, to infer sequence/structure/function/dynamics of proteins, mainly those of the ESKAPE group, deeply involved in Antibio-Microbial Resistance (AMR). AMR is a major threat worldwide and the major cause of mortality by 2050. In line with that, and in collaboration with N. Rama Rao from Micalis, and J-C Cintrat form CEA, we have a current focus in potentiating selected hits into leads to optimise the inhibition of Mfd -Mutation frequency decline- an innovative target involved in DNA repair and mutational evolutions in bacteria. My second interest deals with prokaryotic signaling through phosphorylation/ dephosphorylation events, mediated by protein Ser/Tyr/Thr kinases/phosphatases, respectively. In line with that my (small ) team has fruitful collaboration with virologists, structuralists and biochemists from Argentina and Uruguay. I am also deeply involved in collaborative projects. For all my projects, i combine structural and computational bioinformatics, molecular modeling expertise, X-ray crystallography skills, with in vitro/in vivo data from my collaborators, whose methods span biophysics, biochemistry, microbiology.document it . Follow me on Linkedin