Gwendal Lazennec

Identifiants chercheurs

IdHAL :

gwendal-lazennec

ORCID :

0000-0002-8522-1763

IdRef :

078635039

Présentation

Directeur de recherche CNRS

Responsable de l'équipe: Chimiokines, microenvironnement et inflammation

Membre du comité de pilotage du GDR 3697 &quot;Micronit&quot; (Microenvironnement des niches tumorales) et co-responsable de l'axe &quot;Biomarkers and therapeutic targeting of tumor niches&quot;.

Adresse prof.: CNRS UMR 9005 Sys2Diag &quot;Modélisation et Ingénierie des systèmes complexes biologiques pour le diagnostic&quot; Cap delta, 1682 rue de la Valsière, 34184 Montpellier Cedex 4, France

Web: https://gwendal-lazennec.fr/

Publications

Article dans une revue (53)

Prognostic Value of Trop-2 Expression in Nonmetastatic Triple-Negative Breast Cancer and Correlation With Emerging Biomarkers. William Jacot,Marie-Christine Chateau,Simon Thezenas,Séverine Guiu,Nelly Firminet al. Cancer Medicine, 2025, 14 (5), pp.e70615. ⟨10.1002/cam4.70615⟩ Article dans une revue hal-04984795v1
CXCR2 chemokine receptor -a master regulator in cancer and physiology Gwendal Lazennec,Krishna Rajarathnam,Ann Richmond Trends in Molecular Medicine, 2024, 30 (1), pp.37-55. ⟨10.1016/j.molmed.2023.09.003⟩ Article dans une revue hal-04403865v1
WHIM Syndrome-linked CXCR4 mutations drive osteoporosis Adrienne Anginot,Julie Nguyen,Zeina Abou Nader,Vincent Rondeau,Amélie Bonaudet al. Nature Communications, 2023, 14 (1), pp.2058. ⟨10.1038/s41467-023-37791-4⟩ Article dans une revue hal-04077290v1
Environmental exposure and the role of AhR in the tumor microenvironment of breast cancer Colleen Sweeney,Gwendal Lazennec,Christoph Vogel Frontiers in Pharmacology, 2022, 13, pp.1095289. ⟨10.3389/fphar.2022.1095289⟩ Article dans une revue hal-03918758v1
CXCR2 intrinsically drives the maturation and function of neutrophils in mice Pauline Delobel,Benjamin Ginter,Eliane Rubio,Karl Balabanian,Gwendal Lazennec Frontiers in Immunology, 2022 Article dans une revue hal-03798339v1
Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer Colin Timaxian,Christoph Vogel,Charlotte Orcel,Diana Vetter,Camille Durochatet al. Cancers, 2021, 13 (11), pp.2584. ⟨10.3390/cancers13112584⟩ Article dans une revue hal-04310542v1
CXCR2 Levels Correlate with Immune Infiltration and a Better Prognosis of Triple-Negative Breast Cancers Florence Boissière-Michot,William Jacot,Océane Massol,Caroline Mollevi,Gwendal Lazennec Cancers, 2021, 13 (10), pp.2328. ⟨10.3390/cancers13102328⟩ Article dans une revue hal-03236436v1
Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer Colin Timaxian,Christoph F A Vogel,Charlotte Orcel,Diana Vetter,Camille Durochatet al. Cancers, 2021, 13 (11), pp.2584. ⟨10.3390/cancers13112584⟩ Article dans une revue hal-03236738v1
Targeting the aryl hydrocarbon receptor signaling pathway in breast cancer development Christoph Vogel,Gwendal Lazennec,Sarah y Kado,Carla Dahlem,Yi Heet al. Frontiers in Immunology, 2021, 12, pp.625346. ⟨10.3389/fimmu.2021.625346⟩ Article dans une revue hal-03186946v1
Prognostic Value of CXCR2 in Breast Cancer Florence Boissière-Michot,William Jacot,Julien Fraisse,Sophie Gourgou,Colin Timaxianet al. Cancers, 2020, 12 (8), pp.2076. ⟨10.3390/cancers12082076⟩ Article dans une revue hal-02914978v1
The health status alters the pituitary function and reproduction of mice in a Cxcr2 -dependent manner Colin Timaxian,Isabelle Raymond-Letron,Céline Bouclier,Linda Gulliver,Ludovic Le Correet al. Life Science Alliance, 2020, 3 (3), pp.e201900599. ⟨10.26508/lsa.201900599⟩ Article dans une revue hal-02476814v1
Recent discoveries concerning the tumor - mesenchymal stem cell interactions Gwendal Lazennec,Paula Lam Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2016, 1866 (2), pp.290-299. ⟨10.1016/j.bbcan.2016.10.004⟩ Article dans une revue hal-02146513v1
Polycyclic Aromatic Hydrocarbons promote Th22 polarization by reciprocally regulating IL-22 and IL- 17 Coline Ple,Ying Fan,Saliha Ait Yahia,Han Vorng,Laetitia Everaereet al. PLoS ONE, 2015, 10 (4), pp.e0122372. ⟨10.1371/journal.pone.0122372⟩ Article dans une revue hal-03002029v1
Polycyclic Aromatic Hydrocarbons Reciprocally Regulate IL-22 and IL-17 Cytokines in Peripheral Blood Mononuclear Cells from Both Healthy and Asthmatic Subjects Coline Plé,Ying Fan,Saliha Ait Yahia,Han Vorng,Laetitia Everaereet al. PLoS ONE, 2015, 10 (4), pp.e0122372. ⟨10.1371/journal.pone.0122372⟩ Article dans une revue hal-02146525v1
IL-1β produced by aggressive breast cancer cells is one of the factors that dictate their interactions with mesenchymal stem cells through chemokine production Pauline Escobar,Céline Bouclier,Julien Serret,Ivan Bièche,Madly Brigitteet al. Oncotarget, 2015, 6 (30), pp.29034-29047. ⟨10.18632/oncotarget.4732⟩ Article dans une revue hal-02146528v1
Characterization of an adaptive immune response in microsatellite-instable colorectal cancer Florence Boissière-Michot,Gwendal Lazennec,Hélène Frugier,Marta Jarlier,Lise Rocaet al. OncoImmunology, 2014, 3 (6), pp.e29256. ⟨10.4161/onci.29256⟩ Article dans une revue hal-02146604v1
Chromatin remodeling protein SMAR1 regulates NF-κB dependent Interleukin-8 transcription in breast cancer Sunil Malonia,Bhawna Yadav,Surajit Sinha,Gwendal Lazennec,Samit Chattopadhyay International Journal of Biochemistry and Cell Biology, 2014, 55, pp.220-226. ⟨10.1016/j.biocel.2014.09.008⟩ Article dans une revue hal-02146532v1
Estrogen receptor signaling as a target for novel breast cancer therapeutics Jack-Michel Renoir,Véronique Marsaud,Gwendal Lazennec Biochemical Pharmacology, 2013, 85 (4), pp.449-465. ⟨10.1016/j.bcp.2012.10.018⟩ Article dans une revue hal-03002141v1
Estrogen receptor signaling as a target for novel breast cancer therapeutics. Jack-Michel Renoir,Véronique Marsaud,Gwendal Lazennec Biochemical Pharmacology, 2013, 85 (4), pp.449-65. ⟨10.1016/j.bcp.2012.10.018⟩ Article dans une revue inserm-00758201v1
Potential Role of Estrogen Receptor Beta as a Tumor Suppressor of Epithelial Ovarian Cancer Carine Bossard,Muriel Busson,David Vindrieux,Françoise Gaudin,Véronique Machelonet al. PLoS ONE, 2012, 7 (9), pp.e44787. ⟨10.1371/journal.pone.0044787⟩ Article dans une revue hal-03002049v1
[PAIR-gynaecology: multi/interdisciplinary for gynecologic cancer research. Problems needed to be resolved]. Isabelle Ray-Coquard,Franck Chauvin,Eric Leblanc,Christophe Caux,Hélène Hoarauet al. Bulletin du Cancer, 2012, 99 (4), pp.479-98. ⟨10.1684/bdc.2012.1558⟩ Article dans une revue hal-00723410v1
Coxsackie and adenovirus receptor is a target and a mediator of estrogen action in breast cancer David Vindrieux,Ludovic Le Corre,Jer-Tsong Hsieh,Raphaël Métivier,Pauline Escobaret al. Endocrine-Related Cancer, 2011, 18 (3), pp.311-321. ⟨10.1530/ERC-10-0230⟩ Article dans une revue hal-03002183v1
Functional integration of the Ah receptor with RelB and IL-8 confers the pro-survival advantage to mammary epithelial cells of inflammatory breast tumors Christoph Franz Adam Vogel,Wen Li,Dalei Wu,Jamie K. Miller,Colleen Sweeneyet al. Archives of Biochemistry and Biophysics, 2011, 512 (1), pp.78-86. ⟨10.1016/j.abb.2011.05.011⟩ Article dans une revue hal-03002041v1
Coxsackie and adenovirus receptor is a target and a mediator of estrogen action in breast cancer. David Vindrieux,Ludovic Le Corre,Jer-Tsong Hsieh,Raphaël Métivier,Pauline Escobaret al. Endocrine-Related Cancer, 2011, 18 (3), pp.311-21. ⟨10.1530/ERC-10-0230⟩ Article dans une revue hal-01117400v1
Functional integration of the Ah receptor with RelB and IL-8 confers the pro-survival advantage to mammary epithelial cells of inflammatory breast tumors Christoph Franz Adam Vogel,Wen Li,Dalei Wu,Jamie Miller,Colleen Sweeneyet al. Archives of Biochemistry and Biophysics, 2011, 512 (1), pp.78-86. ⟨10.1016/j.abb.2011.05.011⟩ Article dans une revue hal-03002191v1
Chemokines and their receptors: new insights in cancer inflammation Gwendal Lazennec,Ann Richmond Trends in Molecular Medicine, 2010, 16 (3), pp.133-144. ⟨10.1016/j.molmed.2010.01.003⟩ Article dans une revue hal-03002095v1
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance C. Chavey,Gwendal Lazennec,S. Lagarrigue,C. Clape,I. Iankovaet al. Cell Metabolism, 2009, 9 (4), pp.339--49. ⟨10.1016/j.cmet.2009.03.002⟩ Article dans une revue hal-02194094v1
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Carine Chavey,Gwendal Lazennec,Sylviane Lagarrigue,Cyrielle Clapé,Irena Iankovaet al. Cell Metabolism, 2009, 9 (4), pp.339-49. ⟨10.1016/j.cmet.2009.03.002⟩ Article dans une revue inserm-00375507v2
CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation. Claudia Amura,Kelley Brodsky,Berenice Gitomer,Kim Mcfann,Gwendal Lazennecet al. American Journal of Physiology - Cell Physiology, 2008, 294 (3), pp.C786-96. ⟨10.1152/ajpcell.00457.2007⟩ Article dans une revue inserm-00268266v1
Phosphorylation of activation function-1 regulates proteasome-dependent nuclear mobility and E6-associated protein ubiquitin ligase recruitment to the estrogen receptor beta. Nathalie Picard,Catherine Charbonneau,Mélanie Sanchez,Anne Licznar,Muriel Bussonet al. Molecular Endocrinology -Baltimore-, 2008, 22 (2), pp.317-30. ⟨10.1210/me.2007-0281⟩ Article dans une revue inserm-00268259v1
Interleukin-8 expression is regulated by histone deacetylases through the nuclear factor-kappaB pathway in breast cancer. Carine Chavey,Marcus Muhlbauer,Carine Bossard,Ariane Freund,Sebastien Durandet al. Molecular Pharmacology, 2008, 74 (5), pp.1359-66. ⟨10.1124/mol.108.047332⟩ Article dans une revue inserm-00308891v1
Concise review: adult multipotent stromal cells and cancer: risk or benefit? Gwendal Lazennec,Christian Jorgensen Stem Cells / Stem Cells (Miamisburg), 2008, 26 (6), pp.1387-94. ⟨10.1634/stemcells.2007-1006⟩ Article dans une revue inserm-00271551v1
Chemokines: novel targets for breast cancer metastasis. Simi Ali,Gwendal Lazennec CANCER AND METASTASIS REVIEW, 2007, 26 (3-4), pp.401-420. ⟨10.1007/s10555-007-9073-z⟩ Article dans une revue inserm-00168311v1
Oestrogen receptor negative breast cancers exhibit high cytokine content. Carine Chavey,Frédéric Bibeau,Sophie Gourgou-Bourgade,Sandrine Burlinchon,Florence Boissièreet al. Breast Cancer Research, 2007, 9 (1), pp.R15. ⟨10.1186/bcr1648⟩ Article dans une revue inserm-00143810v1
High tumoral levels of Kiss1 and G-protein-coupled receptor 54 expression are correlated with poor prognosis of estrogen receptor-positive breast tumors. D. Marot,I. Bieche,C. Aumas,S. Esselin,C. Bouquetet al. Endocrine-Related Cancer, 2007, 14 (3), pp.691-702 Article dans une revue hal-00177513v1
RelB, a new partner of aryl hydrocarbon receptor-mediated transcription. Christoph F. A. Vogel,Eric Sciullo,Wen Li,Pat Wong,Gwendal Lazennecet al. Molecular Endocrinology -Baltimore-, 2007, 21 (12), pp.2941-55. ⟨10.1210/me.2007-0211⟩ Article dans une revue inserm-00268250v1
Differential regulation of RANTES and IL-8 expression in lung adenocarcinoma cells. Corinne Henriquet,Claire Gougat,Audrey Combes,Gwendal Lazennec,Marc Mathieu Lung Cancer, 2007, 56 (2), pp.167-74. ⟨10.1016/j.lungcan.2006.12.003⟩ Article dans une revue inserm-00143972v1
CXC chemokines located in the 4q21 region are up-regulated in breast cancer. Ivan Bièche,Carine Chavey,Catherine Andrieu,Muriel Busson,Sophie Vacheret al. Endocrine-Related Cancer, 2007, 14 (4), pp.1039-1052. ⟨10.1677/erc.1.01301⟩ Article dans une revue inserm-00153602v1
Regulation of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR by estradiol through VEGF in uterus M a J Hervé,G Meduri,F G Petit,T S Domet,Gwendal Lazennecet al. Journal of Endocrinology, 2006, 188 (1), pp.91-99. ⟨10.1677/joe.1.06184⟩ Article dans une revue hal-02441847v1
Estrogen receptor beta, a possible tumor suppressor involved in ovarian carcinogenesis. Gwendal Lazennec Cancer Letters, 2006, 231 (2), pp.151-7. ⟨10.1016/j.canlet.2005.01.021⟩ Article dans une revue inserm-00143901v1
ERalpha and ERbeta expression and transcriptional activity are differentially regulated by HDAC inhibitors. Vanessa Duong,Anne Licznar,Raphaël Margueron,Nathalie Boulle,Muriel Bussonet al. Oncogene, 2006, 25 (12), pp.1799-806. ⟨10.1038/sj.onc.1209102⟩ Article dans une revue inserm-00143967v1
The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene. Jean-Sébastien Annicotte,Carine Chavey,Nadège Servant,Jacques Teyssier,Aurélie Bardinet al. Oncogene, 2005, 24 (55), pp.8167-75. ⟨10.1038/sj.onc.1208950⟩ Article dans une revue inserm-00144663v1
Expression of estrogen receptor beta in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis. Jennifer Cheng,Eun Jig Lee,Laird D. Madison,Gwendal Lazennec FEBS Letters, 2004, 566 (1-3), pp.169-72. ⟨10.1016/j.febslet.2004.04.025⟩ Article dans une revue inserm-00143968v1
Mechanisms underlying differential expression of interleukin-8 in breast cancer cells. Ariane Freund,Valérie Jolivel,Sébastien Durand,Nathalie Kersual,Dany Chalboset al. Oncogene, 2004, 23 (36), pp.6105-14. ⟨10.1038/sj.onc.1207815⟩ Article dans une revue inserm-00143639v1
Loss of ERbeta expression as a common step in estrogen-dependent tumor progression. Allison Bardin,Nathalie Boulle,Gwendal Lazennec,Françoise Vignon,Pascal Pujol Endocrine-Related Cancer, 2004, 11 (3), pp.537-51 Article dans une revue inserm-00153815v1
Identification of genes involved in growth inhibition of breast cancer cells transduced with estrogen receptor. Anne Licznar,Simona Caporali,Annick Lucas,Alessandro Weisz,Françoise Vignonet al. FEBS Letters, 2003, 553 (3), pp.445-50 Article dans une revue inserm-00143969v1
Comparative transductions of breast cancer cells by three DNA viruses. Annick Lucas,Eric J. Kremer,Silvio Hemmi,José Luis,Françoise Vignonet al. Biochemical and Biophysical Research Communications, 2003, 309 (4), pp.1011-6. ⟨10.1016/j.bbrc.2003.08.101⟩ Article dans une revue inserm-00143970v1
IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells. Ariane Freund,Corine Chauveau,Jean-Paul Brouillet,Annick Lucas,Matthieu Lacroixet al. Oncogene, 2003, 22 (2), pp.256-65. ⟨10.1038/sj.onc.1206113⟩ Article dans une revue inserm-00143840v1
Involvement of cyclic AMP response element binding protein (CREB) and estrogen receptor phosphorylation in the synergistic activation of the estrogen receptor by estradiol and protein kinase activators. Gwendal Lazennec,James P. Thomas,Benita S. Katzenellenbogen Journal of Steroid Biochemistry and Molecular Biology, 2001, 77 (4-5), pp.193-203 Article dans une revue inserm-00143971v1
ER beta inhibits proliferation and invasion of breast cancer cells. Gwendal Lazennec,Damien Bresson,Annick Lucas,Corine Chauveau,Françoise Vignon Endocrinology, 2001, 142 (9), pp.4120-30 Article dans une revue inserm-00153812v1
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators. Gwendal Lazennec,Laurence Canaple,Damien Saugy,Walter Wahli Molecular Endocrinology -Baltimore-, 2000, 14 (12), pp.1962-75 Article dans une revue inserm-00153813v1
Regulation of gene expression and biological activity of rainbow trout estrogen receptor F. Pakdel,F. Delaunay,B. Ducouret,G. Flouriot,L. Kernet al. Fish Physiology and Biochemistry, 1997, 17 (1/6), pp.123-133. ⟨10.1023/A:1007706207857⟩ Article dans une revue istex hal-02442869v1
The sheep estrogen receptor : cloning and regulation of expression in the hypothalamo-pituitary axis T. Madigou,C. Tiffoche,Gwendal Lazennec,Julien Pelletier,M.L. Thieulant Molecular and Cellular Endocrinology, 1996, 121, pp.153-163 Article dans une revue hal-02690364v1