Hélène Bénédetti

Publications

Article dans une revue (67)

An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection Mohammed Bergoug,Christine Mosrin-Huaman,Amandine Serrano,Fabienne Godin,Michel Doudeauet al. Journal of Molecular Biology, 2024, 436 (22), pp.168768. ⟨10.1016/j.jmb.2024.168768⟩ Article dans une revue hal-04771131v1
Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization Anthony Champiré,Rayan Berabez,Abdennour Braka,Aurélie Cosson,Justine Corretet al. European Journal of Medicinal Chemistry, 2024, 271, pp.116391-116391. ⟨10.1016/j.ejmech.2024.116391⟩ Article dans une revue hal-04575964v1
LIM Kinases: From Molecular to Pathological Features Hélène Bénédetti,Béatrice Vallée Cells, 2023, 12 (12), pp.1649. ⟨10.3390/cells12121649⟩ Article dans une revue hal-04208415v1
LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features Elodie Villalonga,Christine Mosrin,Thierry Normand,Caroline Girardin,Amandine Serranoet al. Cells, 2023, 12 (5), pp.805. ⟨10.3390/cells12050805⟩ Article dans une revue (article de synthèse) hal-04208405v1
LIM kinases, promising but reluctant therapeutic targets: chemistry and preclinical validation in vivo Rayan Berabez,Sylvain Routier,Hélène Bénédetti,Karen Plé,Béatrice Vallée Cells, 2022, 11 (13), pp.2090. ⟨10.3390/cells11132090⟩ Article dans une revue hal-03721458v1
Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper Bojan Žunar,Christine Mosrin-Huaman,Hélène Bénédetti,Béatrice Vallée Biosensors and Bioelectronics, 2022, 214, pp.114502. ⟨10.1016/j.bios.2022.114502⟩ Article dans une revue hal-03820214v1
A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation Skander A Abboud,Hadji H.,Michel Doudeau,Hélène Bénédetti,Vincent Aucagne Chemical Science, 2021, 12, pp.3194 - 3201. ⟨10.1039/d0sc06001a⟩ Article dans une revue hal-03447239v1
Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors Frédéric Buron,Nuno Rodrigues,Thibault Saurat,Marie-Aude Hiebel,Stéphane Bourget al. Molecules, 2021, 26 (17), pp.5349. ⟨10.3390/molecules26175349⟩ Article dans une revue hal-03348966v1
The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes Wissem Deraredj Nadim,Shalina Hassanaly,Hélène Bénédetti,Claudine Kieda,Catherine Grillonet al. Biochemical and Biophysical Research Communications, 2021, 534, pp.758-764. ⟨10.1016/j.bbrc.2020.11.003⟩ Article dans une revue hal-03007433v1
Neurofibromin Structure, Functions and Regulation Mohammed Bergoug,Michel Doudeau,Fabienne Godin,Christine Mosrin-Huaman,Béatrice Valléeet al. Cells, 2020, 9, ⟨10.3390/cells9112365⟩ Article dans une revue hal-03070759v2
LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability Julie Tastet,Hélène Cuberos,Béatrice Vallée,Annick Toutain,Martine Raynaudet al. Neuroscience, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩ Article dans une revue istex hal-02067472v1
Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein Béatrice Vallée,Michel Doudeau,Fabienne Godin,Hélène Bénédetti Journal of visualized experiments : JoVE, 2019, 148, pp.e59820. ⟨10.3791/59820⟩ Article dans une revue hal-02282630v1
LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b Béatrice Vallée,Hélène Cuberos,Michel Doudeau,Fabienne Godin,David Gossetet al. Biochemical Journal, 2018, 475 (23), pp.3745-3761 Article dans une revue hal-01966439v1
Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities Viorel Simion,Wissem Deraredj Nadim,Hélène Bénédetti,Chantal Pichon,Séverine Morisset-Lopezet al. Current Neuropharmacology, 2017, 15 (2), pp.276 - 290. ⟨10.2174/1570159X14666160630210422⟩ Article dans une revue hal-01618771v1
MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments? Wissem Deraredj Nadim,Simion Viorel,Hélène Bénédetti,Chantal Pichon,Patrick Barilet al. Current Neuropharmacology, 2017, 15 (2), pp.260 - 275. ⟨10.2174/1570159X14666160709001441⟩ Article dans une revue hal-01618199v1
Physical interaction between neurofibromin and serotonin 5-HT 6 receptor promotes receptor constitutive activity Wissem Deraredj Nadim,Séverine Chaumont-Dubel,Fahima Madouri,Laetitia Cobret,Marie-Ludivine de Tauziaet al. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (43), pp.12310 - 12315. ⟨10.1073/pnas.1600914113⟩ Article dans une revue hal-01407899v1
Mutation screening of the ubiquitin ligase gene RNF135 in French patients with autism Julie Tastet,Loïc Decalonne,Sylviane Marouillat,Joëlle Malvy,Rose-Anne Thépaultet al. Psychiatric Genetics, 2015, 25 (6), pp.263-267. ⟨10.1097/ypg.0000000000000100⟩ Article dans une revue hal-02072312v1
Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling L Cobret,M L de Tauzia,J Ferent,E Traiffort,I Hénaouiet al. British Journal of Clinical Pharmacology, 2015, 172 (3), pp.841-856. ⟨10.1111/bph.12945⟩ Article dans une revue hal-01170735v1
Roles of LIM kinases in central nervous system function and dysfunction H. Cuberos,B. Vallée,Patrick Vourc’h,J. Tastet,Christian R Andreset al. FEBS Letters, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩ Article dans une revue hal-02072231v1
Microwave Assisted Organic Synthesis (MAOS) of New Dispacamide A Derivatives Bearing a Thiazolinone Platform, Biological Assays on Inhibition of Protein Kinases and Cell Effects Solene Guiheneuf,Ludovic Paquin,Francois Carreaux,Emilie Durieu,Helene Benedettiet al. Current microwave chemistry, 2014, 1 (1), pp.33-40. ⟨10.2174/22133356114019990002⟩ Article dans une revue istex hal-01114583v1
Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors Amélie Bruel,Romain Beneteau,Mylène Chabanne,Olivier Lozach,Rémy Le Guevelet al. Bioorganic and Medicinal Chemistry Letters, 2014, 24 (21), pp.5037 - 5040. ⟨10.1016/j.bmcl.2014.09.017⟩ Article dans une revue hal-01086026v1
New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway Reine Nehmé,Hala Nehmé,Thibault Saurat,Marie-Ludivine De-Tauzia,Frédéric Buronet al. Analytical and Bioanalytical Chemistry, 2014, 406 (15), pp.3743-3754. ⟨10.1007/s00216-014-7790-z⟩ Article dans une revue hal-01180770v1
Design, Synthesis, and Biological Activity of Pyridopyrimidine Scaffolds as Novel PI3K/mTOR Dual Inhibitors Thibault Saurat,Frédéric Buron,Nuno Rodrigues,Marie-Ludivine de Tauzia,Lionel Colliandreet al. Journal of Medicinal Chemistry, 2014, 57 (3), pp.613-631. ⟨10.1021/jm401138v⟩ Article dans une revue hal-01180887v1
Characterization of histidine-aspartate kinase HK1 and identification of histidine phosphotransfer proteins as potential partners in a Populus multistep phosphorelay François Hericourt,François Chefdor,Lucie Bertheau,Mirai Tanigawa,Tatsuya Maedaet al. Physiologia Plantarum, 2013, 149 (2), pp.188-199. ⟨10.1111/ppl.12024⟩ Article dans une revue istex hal-02070851v1
Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5Hpyridazino[4,5-b]indoles as PI3Ka inhibitors. A. Bruel,Cedric Logé,M.-L. de Tauzia,M. Ravache,Ronan Le Guévelet al. European Journal of Medicinal Chemistry, 2012, 57, pp.225-233 Article dans une revue hal-00764872v1
Expression analysis of LIM gene family in poplar, toward an updated phylogenetic classification. Dominique Arnaud,Annabelle Déjardin,Jean-Charles Leplé,Marie-Claude Lesage-Descauses,Nathalie Boizotet al. BMC Research Notes, 2012, 5, pp.102. ⟨10.1186/1756-0500-5-102⟩ Article dans une revue hal-00721759v1
Nf1 RasGAP Inhibition of LIMK2 Mediates a New Cross-Talk between Ras and Rho Pathways Béatrice Vallée,Michel Doudeau,Fabienne Godin,Aurélie Gombault,Aurélie Tchalikian-Cossonet al. PLoS ONE, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩ Article dans une revue hal-03054185v1
Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast. Martine Beaufour,Fabienne Godin,Béatrice Vallée,Martine Cadene,Hélène Bénédetti Journal of Proteome Research, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩ Article dans une revue hal-00721771v1
LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain Julie Tastet,Patrick Vourc’h,Frédéric Laumonnier,Béatrice Vallée,Carole Michelleet al. Biochemical and Biophysical Research Communications, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩ Article dans une revue istex hal-01136281v1
A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line. Fabienne Godin,Sandrine Villette,Béatrice Vallée,Michel Doudeau,Séverine Morisset-Lopezet al. Biochemical and Biophysical Research Communications, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩ Article dans une revue istex hal-00721861v1
A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY Aurélie Gombault,Jonas Warringer,Robert Caesar,Fabienne Godin,Béatrice Valléeet al. FEMS Yeast Research, 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩ Article dans une revue hal-00522432v1
Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study Aurélie Gombault,Fabienne Godin,Denise Sy,Baptiste Legrand,Hélène Chautardet al. Journal of Molecular Biology, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩ Article dans une revue istex hal-00181161v1
Osmotic stress sensing in Populus: components identification of a phosphorelay system F. Chefdor,H. Bénédetti,C. Depierreux,Franck Delmotte,D. Morabitoet al. FEBS Letters, 2006, 580 (1), pp.77-81. ⟨10.1016/j.febslet.2005.11.051⟩ Article dans une revue hal-00088838v1
Crystal structure of yeast YHR049W/FSH1, a member of the serine hydrolase family S. Quevillon-Cheruel,N. Leulliot,M. Graille,N. Hervouet,F. Costeet al. Protein Science, 2005, 14, pp.1350-1356 Article dans une revue hal-00088667v1
Train A, an RNase-A-like protein without RNase activity is secreted and reabsorbed by the same epididymal cells under testicular control S. Castella,Hélène Bénédetti,R. de Llorens,J.L. Dacheux,F. Dacheux Biology of Reproduction, 2004, 71 (5), pp.1677-1687. ⟨10.1095/biolreprod.104.031666⟩ Article dans une revue hal-00112960v1
Tfs1, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase activating protein in Saccharomyces cerevisiae H. Chautard,M. Jacquer,F. Schoentgen,N. Bureaud,H. Bénédetti Eukaryotic Cell, 2004, 3 (2), pp.459-470. ⟨10.1128/EC.3.2.459-470.2004⟩ Article dans une revue hal-00112967v1
Analysis of the Escherichia coli Tol-Pal and TonB systems by periplasmic production of Tol, TonB, colicin, or phage capsid soluble domains. Emmanuelle Bouveret,Laure Journet,Anne Walburger,E. Cascales,Hélène Bénédettiet al. Biochimie, 2002, 84 (5-6), pp.413-21 Article dans une revue hal-02130103v1
Crystal structures of YBHB and YBCL from Escherichia coli , two bacterial homologues to a Raf kinase inhibitor protein 1 1Edited by R. Huber Laurence Serre,F Serre,Charles Zelwer,Nicole Bureaud,Francoise Schoentgenet al. Journal of Molecular Biology, 2001, 310 (3), pp.617-634. ⟨10.1006/jmbi.2001.4784⟩ Article dans une revue istex hal-02130120v1
Import of colicins across the outer membrane of Escherichia coli involves multiple protein interactions in the periplasm. Laure Journet,E. Bouveret,A. Rigal,R Lloubes,C Lazdunskiet al. Molecular Microbiology, 2001, 42 (2), pp.331-44 Article dans une revue hal-02130124v1
Colicin import into Escherichia coli cells requires the proximity of the inner and outer membranes and other factors C. Lazdunski,E. Bouveret,A Rigal,Laure Journet,R. Lloubeset al. International Journal of Medical Microbiology, 2000, 290 (4-5), pp.337-344. ⟨10.1016/S1438-4221(00)80037-5⟩ Article dans une revue istex hal-02130686v1
In vitro characterization of peptidoglycan-associated lipoprotein (PAL)-peptidoglycan and PAL-TolB interactions. E Bouveret,H Bénédetti,A Rigal,E. Loret,C Lazdunski Journal of Bacteriology, 1999, 181 (20), pp.6306-11 Article dans une revue hal-02130134v1
Role of TolR N-terminal, central, and C-terminal domains in dimerization and interaction with TolA and tolQ. Laure Journet,A Rigal,C Lazdunski,H Bénédetti Journal of Bacteriology, 1999, 181 (15), pp.4476-84 Article dans une revue hal-02130149v1
Structure of the Escherichia coli TolB protein determined by MAD methods at 1.95 A resolution. Chantal Abergel,E. Bouveret,J.M Claverie,K Brown,A Rigalet al. Structure, 1999, 7 (10), pp.1291-300 Article dans une revue hal-02130130v1
Colicin import into Escherichia coli cells. C.J Lazdunski,E. Bouveret,A. Rigal,Laure Journet,R Lloubèset al. Journal of Bacteriology, 1998, 180 (19), pp.4993-5002 Article dans une revue hal-02130152v1
Distinct regions of the colicin A translocation domain are involved in the interaction with TolA and TolB proteins upon import into Escherichia coli. E Bouveret,A Rigal,C Lazdunski,H Bénédetti Molecular Microbiology, 1998, 27 (1), pp.143-57 Article dans une revue hal-02130155v1
Crystallization and preliminary crystallographic study of a component of the Escherichia coli tol system: TolB. Chantal Abergel,A Rigal,S Chenivesse,C Lazdunski,J.M Claverieet al. Acta crystallographica Section D : Structural biology [1993-..], 1998, 54 (Pt 1), pp.102-4 Article dans une revue hal-02130160v1
The TolB protein interacts with the porins of Escherichia coli. A Rigal,E. Bouveret,R Lloubes,C Lazdunski,H Bénédetti Journal of Bacteriology, 1997, 179 (23), pp.7274-7279. ⟨10.1128/jb.179.23.7274-7279.1997⟩ Article dans une revue hal-02130169v1
The N-terminal domain of colicin E3 interacts with TolB which is involved in the colicin translocation step. E Bouveret,A Rigal,C Lazdunski,H Bénédetti Molecular Microbiology, 1997, 23 (5), pp.909-20 Article dans une revue hal-02130173v1
TolA central domain interacts with Escherichia coli porins. R Derouiche,M Gavioli,H Bénédetti,A Prilipov,C Lazdunskiet al. EMBO Journal, 1996, 15 (23), pp.6408-15 Article dans une revue hal-02130175v1
Protein complex within Escherichia coli inner membrane. TolA N-terminal domain interacts with TolQ and TolR proteins R Derouiche,H Bénédetti,Jc Lazzaroni,C Lazdunski,R Lloubès Journal of Biological Chemistry, 1995, 270 (19), pp.11078-11084. ⟨10.1074/jbc.270.19.11078⟩ Article dans une revue hal-02130187v1
Transmembrane α-Helix Interactions are Required for the Functional Assembly of theEscherichia coliTol Complex Jean Claude Lazzaroni,Anne Vianney,V Vianney,Jean Luc Popot,Hélène Bénédettiet al. Journal of Molecular Biology, 1995, 246 (1), pp.1-7. ⟨10.1006/jmbi.1994.0058⟩ Article dans une revue istex hal-02130202v1
Quantification of group A colicin import sites. Denis Duché,L. Letellier,V Géli,H Bénédetti,D. Baty Journal of Bacteriology, 1995, 177 (17), pp.4935-4939. ⟨10.1128/jb.177.17.4935-4939.1995⟩ Article dans une revue hal-02130183v1
Peptidoglycan-associated lipoprotein-TolB interaction. A possible key to explaining the formation of contact sites between the inner and outer membranes of Escherichia coli E. Bouveret,R Derouiche,R. Rigal,R Lloubès,C Lazdunskiet al. Journal of Biological Chemistry, 1995, 270 (19), pp.11071-11077. ⟨10.1074/jbc.270.19.11071⟩ Article dans une revue hal-02130195v1
Quantification of group A colicin import sites. Denis Duché,L. Letellier,V. Geli,H. Bénédetti,D. Baty Journal of Bacteriology, 1995, 177 (17), pp.4935-4939. ⟨10.1128/jb.177.17.4935-4939.1995⟩ Article dans une revue hal-02440962v1
Colicin A and the Tol proteins involved in its translocation are preferentially located in the contact sites between the inner and outer membranes of Escherichia coli cells. G. Guihard,P. Boulanger,H Bénédetti,R Lloubés,M Besnardet al. Journal of Biological Chemistry, 1994, 269 (8), pp.5874-80 Article dans une revue hal-02130218v1
The colicin A pore-forming domain fused to mitochondrial intermembrane space sorting signals can be functionally inserted into the Escherichia coli plasma membrane by a mechanism that bypasses the Tol proteins David Espesset,Yves Corda,Kyle Cunningham,Hélène Bénédetti,Roland Lloubeset al. Molecular Microbiology, 1994, 13 (6), pp.1121-1131. ⟨10.1111/j.1365-2958.1994.tb00503.x⟩ Article dans une revue hal-02130213v1
The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast. H Bénédetti,S Raths,F Crausaz,H. Riezman Molecular Biology of the Cell, 1994, 5 (9), pp.1023-37 Article dans une revue hal-02130204v1
Phosphate efflux through the channels formed by colicins and phage T5 in Escherichia coli cells is responsible for the fall in cytoplasmic ATP. G. Guihard,H Bénédetti,M Besnard,L. Letellier Journal of Biological Chemistry, 1993, 268 (24), pp.17775-80 Article dans une revue hal-02130233v1
Recognition of the colicin A N-terminal epitope 1C11 in vitro and in vivo in Escherichia coli by its cognate monoclonal antibody V Geli,R Lloubes,S Zaat,R van Spaendonk,C Rollinet al. FEMS Microbiology Letters, 1993, 109 (2-3), pp.335-342. ⟨10.1016/0378-1097(93)90042-z⟩ Article dans une revue hal-02130222v1
Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast. J Rohrer,H Bénédetti,B Zanolari,H. Riezman Molecular Biology of the Cell, 1993, 4 (5), pp.511-21 Article dans une revue hal-02130242v1
Colicin A unfolds during its translocation in Escherichia coli cells and spans the whole cell envelope when its pore has formed. Hélène Bénédetti,R Lloubès,C Lazdunski,L. Letellier EMBO Journal, 1992, 11 (2), pp.441-7 Article dans une revue hal-02130272v1
Protein import into Escherichia coli: colicins A and E1 interact with a component of their translocation system. Hélène Bénédetti,C Lazdunski,R Lloubès EMBO Journal, 1991, 10 (8), pp.1989-95 Article dans une revue hal-02130277v1
Construction, expression and release of hybrid colicins. M Frenette,H Bénédetti,A. Bernadac,D. Baty,C Lazdunski Journal of Molecular Biology, 1991, 217 (3), pp.421-8 Article dans une revue hal-02130287v1
Individual domains of colicins confer specificity in colicin uptake, in pore-properties and in immunity requirement. Hélène Bénédetti,M Frenette,D. Baty,M Knibiehler,F. Pattuset al. Journal of Molecular Biology, 1991, 217 (3), pp.429-39 Article dans une revue hal-02130283v1
Uptake across the cell envelope and insertion into the inner membrane of ion channel-forming colicins in E coli D. Baty,F. Pattus,M. Parker,H. Bénédetti,M. Frenetteet al. Biochimie, 1990, 72 (2-3), pp.123-130. ⟨10.1016/0300-9084(90)90137-6⟩ Article dans une revue istex hal-02130296v1
Insertion and translocation of proteins into and through membranes. C. Lazdunski,H Bénédetti FEBS Letters, 1990, 268 (2), pp.408-14 Article dans une revue hal-02130669v1
Comparison of the Uptake Systems for the Entry of Various BtuB Group Colicins into Escherichia coli H. Bénédetti,M. Frenette,D. Baty,R Lloubès,V. Geliet al. Microbiology, 1989, 135 (12), pp.3413-3420. ⟨10.1099/00221287-135-12-3413⟩ Article dans une revue hal-02130300v1

Communication dans un congrès (16)

Synthesis and preclinical validation of LIMKs inhibitors: Promising drugs for osteosarcoma treatment? Anthony Champiré,Margaux Sainjon,Abdennour Braka,Samia Aci-Seche,Pascal Bonnetet al. XXVII EFMC International Symposium on Medicinal Chemistry, Sep 2022, NICE, France Communication dans un congrès hal-04823073v1
Synthesis and preclinical validation of LIMKs inhibitors: Promising drugs for osteosarcoma treatment? Rayan Berabez,Anthony Champiré,Margaux Sainjon,Abdennour Braka,Samia Aci-Secheet al. SCT 29th Young Research Fellow Meeting, Jul 2022, Nantes, France Communication dans un congrès hal-04822252v1
Séminaire invité : Signalisation cellulaire et Neurofibromatose Béatrice Vallée,Hélène Bénédetti Journées NF, Sep 2021, Orléans, France Communication dans un congrès hal-03560050v1
Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel Béatrice Vallée,Christine Mosrin-Huaman,Hélène Bénédetti,Régis Guégan,Bojan Zunar ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria Communication dans un congrès hal-03559939v1
High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells N Laroui,C Delehedde,C Goncalves,F Godin,Federico Percheet al. SFNano 2021, Dec 2021, Angers, France Communication dans un congrès hal-03668422v1
Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action Justine Corret,Sokaina Hammoud,Frédéric Buron,Pierre Daligaux,Christophe Chesnéet al. FEBS 2021, the 45th FEBS Congress, Jul 2021, Virtual, France Communication dans un congrès hal-03668584v1
Détermination et mise en œuvre d’un modèle in vivo pour tester de nouveaux inhibiteurs originaux des LIM kinases, cibles thérapeutiques émergentes dans le cancer Béatrice Vallée,K. Plé,A. Cosson,M. Doudeau,F. Godinet al. Cancéropôle Grand Ouest, Colloque du Réseau Molécules marines, métabolisme et cancer, May 2019, Mansigné, France Communication dans un congrès hal-02928507v1
Les LIM kinases : nouvelles cibles thérapeutiques anti-cancer H. Bénédetti,Béatrice Vallée,A. Cosson,F. Godin,M. Doudeau Journée scientifique du réseau « Cancers hormonaux–dépendants » du Cancéropôle Grand-Ouest, Apr 2019, Nantes, France Communication dans un congrès hal-02928496v1
Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease M. Bergoug,A. Cosson,D. Casas,M. Doudeau,F. Godinet al. 6th LIA Workshop on "Biomarkers and mediators of diseases and new approaches in repair/regenerative therapies, Jun 2019, Varsovie, Poland Communication dans un congrès hal-02928511v1
Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1 M. Bergoug,A. Cosson,M. Doudeau,F. Godin,Béatrice Valléeet al. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France Communication dans un congrès hal-02928220v1
Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose Béatrice Vallée,Karen Plé,A. Cosson,M. Doudeau,F. Godinet al. Journée Fédération CBM-ICOA, Jan 2018, Orléans, France Communication dans un congrès hal-02928530v1
Développement de modulateurs des LIM kinases Béatrice Vallée,S. Routier,A. Cosson,M. Doudeau,F. Godinet al. Cancéropôle Grand Ouest - 14e colloque du Réseau Produits de la mer en cancérologie - 5e colloque du Réseau Canaux ioniques et cancer, May 2018, Mansigné, France Communication dans un congrès hal-02928559v1
Neurofibromatosis type I: from basic to applied research Béatrice Vallée,A. Cosson,M. Doudeau,F Godin,A. Brakaet al. 4th LIA Workshop, Jun 2017, Cracovie, Poland Communication dans un congrès hal-02928517v1
Study of new partners of neurofibromin: an approach to identify novel therapeutic targets for neurofibromatosis type 1 Béatrice Vallée,Hélène Bénédetti,F. Godin,M. Doudeau 17th European Neurofibromatosis meeting, Sep 2016, Albano-Terme, Italy Communication dans un congrès hal-02928226v1
Both ChIP-SEQ and in planta gene modification demonstrate the involvement of MYB090 and MYB156 in secondary cell wall formation in poplar Wassim Lakhal,Nathalie Boizot,Marie-Claude Lesage Descauses,Odile Rogier,Véronique Laine-Pradeet al. INUPRAG-Meeting 2015, Oct 2015, Nancy, France Communication dans un congrès hal-01604786v1
Expression des isoformes de LIM Kinase 2 pendant la neurogenèse et la stimulation des neurones J. Tastet,P. Vourc'H,F. Laumonnier,C. Michelle,Anne Duittozet al. 22. Colloque Biotechnocentre, Oct 2009, Seillac, France Communication dans un congrès hal-02753426v1

Poster de conférence (33)

Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation Mohammed Bergoug,Christine Mosrin-Huaman,Amandine Serrano,Fabienne Godin,Michel Doudeauet al. 2024 Global NF Conference, Jun 2024, Brussels, Belgium Poster de conférence hal-04778711v1
Characterization of a new Post Translational Modification of Neurofibromin: atypical structural requirements for its SUMOylation Mohammed Bergoug,Christine Mosrin-Huaman,Amandine Serrano,Fabienne Godin,Michel Doudeauet al. 2024 Global NF Conference, Jun 2024, Brussels, Belgium Poster de conférence hal-03679991v1
An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection Hélène Bénédetti,Christine Mosrin,Amandine Serrano,Mohammed Bergoug,Fabienne Godinet al. Ubiquitin and ubiquitin−like proteins in health and disease, Sep 2024, Cavtat, Croatia Poster de conférence hal-05228729v1
Deciphering the Molecular Mechanism of Pathogenicity in Destabilized variants of Neurofibromin mutated in its SecPH domain Hélène Bénédetti,Christine Mosrin-Huaman,Mohammed Bergoug,Amandine Serrano,Fabienne Godinet al. 2024 Global NF Conference, Jun 2024, Brussels (Belgium), Belgium Poster de conférence hal-04779581v1
Les LIM kinases, des cibles thérapeutiques prometteuses pour le traitement du glioblastome : de la conception de petites molécules inhibitrices aux tests cellulo Karen Plé,B. Vallée,R. Berabez,A. Champiré,M. Sainjonet al. CCCancéropôle Grand Ouest, colloque du réseau Molécules marines, métabolisme et cancer, May 2023, Mansigné, France Poster de conférence hal-04556346v1
Development of a bio­active fluorescent inhibitor probe targeting the Rho kinase ROCK for monitoring inhibition action Justine Corret,Sokaina Hammoud,Frédéric Buron,Pierre Daligaux,Christophe Chesnéet al. FEBS 2021, the 45th FEBS Congress, Jul 2021, Lnubljana, virtual, Slovenia Poster de conférence hal-03679980v1
New molecular insights into the crosstalk between Rho/ROCK/LIMK2/cofilin signalling pathway and Nf1 Mélissa Thomas,Lauren Blot,Kevin Lesage,Fabienne Godin,Michel Doudeauet al. 2021 NF1 virtual conference, Jun 2021, Virtual, France Poster de conférence hal-03679999v1
Stressed by hydrogel? Physiological response of yeast cells embedded in thermoresponsive Pluronic F127: a prerequisite for bioreactor development Bojan Zunar,Christine Mosrin-Huaman,Hélène Bénédetti,Régis Guégan,Béatrice Vallée FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, Slovenia Poster de conférence hal-03679975v1
New insights into the regulation of actin cytoskeleton dynamics via the Rho/ROCK/LIMK2/cofilin signalling pathway: a novel mechanism of regulation of cofilin by LIMK2 Elodie Villalonga,Célina Chalal,Déborah Cassas,Michel Doudeau,Fabienne Godinet al. FEBS 2021, the 45th FEBS Congress, Jul 2021, Ljubljana, virtual, Slovenia Poster de conférence hal-03680139v1
High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells N Laroui,C Delehedde,Cristine Gonçalves,F Godin,F Percheet al. 10th mRNA Health Conference, Nov 2021, Berlin, Germany Poster de conférence hal-03668434v1
Sumoylation of Neurofibromin and its SecPH Domain Plays a Role in Their Functions and Implies Unexpected Structural Requirements Christine Mosrin-Huaman,Mohammed Bergoug,Fabienne Godin,Michel Doudeau,Iva Sosicet al. 2021 NF1 virtual conference, Jun 2021, Virtual, France Poster de conférence hal-03680001v1
Life in the bioink: Physiology and energetics of Saccharomyces cerevisiae embedded in polymerized Pluronic F127-DMA, a “smart” thermoresponsive hydrogel Bojan Zunar,Christine Mosrin-Huaman,Hélène Bénédetti,Régis Guégan,Béatrice Vallée ICY15 meets 30ICYGMB, The spirit of Yeast, Aug 2021, Vienne, virtual, Austria Poster de conférence hal-03679966v1
Neurofibromin, a new SUMO target involved in neurofibromatosis type 1 disease M. Bergoug,I. Sošic,M. Doudeau,F. Godin,Béatrice Valléeet al. EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia Poster de conférence hal-02924095v1
LIM kinases, new therapeutic targets to treat cancers, neurological disorders and Neurofibromatosis: development of small molecule inhibitors Béatrice Vallée,A. Cosson,M. Doudeau,F. Godin,A. Champiréet al. FEBS Meeting 2019, Jul 2019, Cracovie, Poland Poster de conférence hal-02924140v1
Study of the different forms of sumoylation of the neurofibromin SecPH domain H. Bénédetti,M. Bergoug,I. Sošic,M. Doudeau,F. Godinet al. EMBO Workshop "The ubiquitin system: Biology, mechanisms and roles in disease", Sep 2019, Cavtat, Croatia Poster de conférence hal-02924090v1
Molecular and functional characterization of LIMK2-1, a hominidae-specific isoform of LIMK2 associated with intellectual disability H. Bénédetti,Béatrice Vallée,J. Tastet,H. Cubéros,A. Toutainet al. NeuroFrance 2019, May 2019, Marseille, France Poster de conférence hal-02924881v1
Yeast biosensors to detect environmental pollutants into effluent waters Christine Mosrin-Huaman,B. Handelaoui,H. Bénédetti,Béatrice Vallée ICYGMB XXIX International Congress on Yeast Genetics and Molecular Biology, Aug 2019, Göteborg, Sweden Poster de conférence hal-02924111v1
LARP6, a RNA−binding protein involved in translation and stability of collagen mRNA, is a new partner of Neurofibromin: Molecular studies and functional implications H. Bénédetti,M. Doudeau,F. Godin,Béatrice Vallée,A. Cossonet al. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France Poster de conférence hal-02924084v1
Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I Béatrice Vallée,A. Cosson,M. Doudeau,F. Godin,A. Champiréet al. Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France Poster de conférence hal-02924077v1
LIM kinases as new therapeutic targets for the treatment of neurofibromatosis type 1 A. Champiré,A. Braka,B. Vallée,M. Doudeau,F. Godinet al. VII International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC) –, Aug 2017, Vienne, Austria Poster de conférence hal-02904794v1
LIM Kinases: new anticancer therapeutic targets Béatrice Vallée,A. Cosson,M. Doudeau,F. Godin,Anthony Champiréet al. Breast Cancer Symposium, Jun 2017, Nantes, France Poster de conférence hal-03680148v1
Design, synthesis and biological evaluation of LIMK inhibitors A. Champiré,A. Braka,Béatrice Vallée,M. Doudeau,F. Godinet al. XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France Poster de conférence hal-02904837v1
Study of the sumoylation of neurofibromin, the protein responsible for neurofibromatosis type 1 M. Bergoug,A. Cosson,M. Doudeau,F. Godin,Béatrice Valléeet al. EMBO Conference "Ubiquitin and SUMO: from molecular mechanisms to system-wide responses, Sep 2017, Cavtat, Croatia Poster de conférence hal-02924070v1
Neurofibromin 1 promotes constitutive activity of native 5−HT6 receptors expressed in mouse prefrontal cortex Séverine Morisset-Lopez,W. Deraredj Nadim,S. Chaumont−dubel,F. Madouri,L. Cobretet al. Neurofrance, May 2017, Bordeaux, France Poster de conférence hal-02973767v1
Unraveling the function of MYB090 and MYB156 in secondary cell wall formation in poplar using both ChIP-SEQ and in planta gene modification approach Annabelle Dejardin,Wassim Lakhal,Nathalie Boizot,Marie-Claude Lesage Descauses,Odile Rogieret al. XIV Cell Wall Meeting, Jun 2016, Chania, Grèce. , 2016, XIV Cell Wall Meeting. Programme and Book of Abstracts Poster de conférence hal-02740921v1
LIM kinases: new therapeutic targets to treat Neurofibromatosis type I Béatrice Vallée,Michel Doudeau,Fabienne Godin,Anthony Champiré,Karen Pléet al. The 7th EMBO meeting, Sep 2016, Mannheim, Germany. Poster de conférence hal-02453490v1
The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways Béatrice Vallée,Hélène Cuberos,Michel Doudeau,Fabienne Godin,Patrick Vourc’het al. EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany. Poster de conférence hal-02453489v1
LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications Hélène Bénédetti,Fabienne Godin,Michel Doudeau,Béatrice Vallée,Marie-Ludivine De Tauziaet al. 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark Poster de conférence hal-02453487v1
Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases A. Champiré,A. Braka,Béatrice Vallée,M. Doudeau,F. Godinet al. 29e colloque de Biotechnocentre, Oct 2016, Seillac, France Poster de conférence hal-02904847v1
LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability Béatrice Vallée,Hélène Cuberos,Julie Tastet,Michel Doudeau,Fabienne Godinet al. 10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark. Poster de conférence hal-02453486v1
Projet Région LiCorNe: LIMK protein inhibitors, new therapeutic agents for treatment of cognitive disorders associated with type I Neurofibromatosis Béatrice Vallée,Michel Doudeau,F. Godin,H. Cubéros,A. Champiréet al. Journée Fédération PCV FR2708, Jan 2016, Orléans, France Poster de conférence hal-02924056v1
A Physical Interaction between Neurofibromin and Serotonin 5-HT6 Receptor Promotes Receptor Constitutive Activity W. Deraredj Nadim,S. Chaumont-Dubel,F. Madouri,L. Cobret,M.-L. de Tauziaet al. 5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France Poster de conférence hal-02973912v1
LIMK2 (LIM kinase2) isoforms are differentially expressed during neuronal differentiation J. Tastet,P. Vourc'H,F. Laumonnier,C. Michelle,Anne Duittozet al. 7. FENS Forum of European Neuroscience, Jul 2010, Amsterdam, Netherlands. n.p., 2010 Poster de conférence hal-02818145v1

Chapitre d'ouvrage (7)

The Tol/PAL and TonB systems : two envelope-spanning protein complexes involved in colicin import in E. coli. Emmanuelle Bouveret,Claude Lazdunski,Hélène Bénédetti Molecular Dynamics of Biomembranes, Springer Berlin Heidelberg, pp.59-69, 1996 Chapitre d'ouvrage hal-02130680v1
Colicin transport, channel formation and inhibition H. Bénédetti,V. Geli Handbook of Biological Physics, pp.665-691, 1996 Chapitre d'ouvrage hal-02130677v1
Insertion of Proteins into Membranes A Survey Vincent Géli,Hélène Bénédetti Membrane biogenesis, pp.21-69, 1994, Subcellular Biochemistry, 978-1-4613-6018-6 Chapitre d'ouvrage hal-02130265v1
Import of Colicins into Escherichia Coli Hélène Bénédetti,Lucienne Letellier,Roland Lloubes,Vincent Géli,Daniel Batyet al. Dynamics of Membrane Assembly, 63, Springer Berlin Heidelberg, pp.315-332, 1992 Chapitre d'ouvrage hal-02130670v1
Study of the Import Mechanisms of Colicins Through Protein Engineering and K+ Efflux Kinetics Hélène Bénédetti,Lucienne Letellier,Roland Lloubes,Vincent Géli,Daniel Batyet al. Bacteriocins, Microcins and Lantibiotics, Springer Berlin Heidelberg, pp.215-223, 1992 Chapitre d'ouvrage hal-02130674v1
In Vivo Properties of Colicin A: Channel Activity and Translocation L. Letellier,C. Lazdunski,H. Bénédetti,J. Bourdineaud,P. Boulanger Bacteriocins, Microcins and Lantibiotics, Springer Berlin Heidelberg, pp.119-125, 1992 Chapitre d'ouvrage hal-02130671v1
Molecular Mechanism of Action of Pore-Forming Colicins and of their Immunity Proteins C. Lazdunski,D. Baty,V. Geli,R. Lloubes,H. Bénédettiet al. Membrane Proteins: Structures, Interactions and Models, pp.413-425, 1992 Chapitre d'ouvrage hal-02130675v1

Brevet (3)

4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-3,6-dihydropyridine-(2H)-carboxamide derivatives as Limk and/or Rock kinases inhibitors for use in the treatment of cancer Sylvain Routier,Hélène Bénédetti,Béatrice Vallée,Pascal Bonnet,Karen Pléet al. France, Patent n° : WO2021239727 A1. AMV. 2021 Brevet hal-03555349v1
TRISUBSTITUTED PYRIDO[2,3-D]PYRIMIDINES, METHODS FOR PREPARING SAME AND THERAPEUTIC USES THEREOF Sylvain Routier,Hélène Bénédetti,Frederic Buron,Marie-Aude Hiebel,Thibault Sauratet al. France, Patent n° : WO2014027081. 2014 Brevet hal-02131560v1
Tools for the identification od LINGO-1, LINGO-2, LINGO-3 and LINGO-4, ligands, and uses thereof Séverine Morisset-Lopez,Hélène Bénédetti France, Patent n° : WO2011121257. BCT. 2011 Brevet hal-02130935v1

Pré-publication, Document de travail (1)

Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants Mohammed Bergoug,Christine Mosrin,Fabienne Godin,Michel Doudeau,Iva Sosicet al. 2022 Pré-publication, Document de travail hal-03668582v1