Henrik Toft Simonsen Professor and Director of the Laboratory. Laboratoire Biotechnologies Végétales plantes aromatiques et médicinales (BVpam)Faculté des Sciences et Techniques, Université Jean Monnet

Identifiants chercheurs

IdHAL :

henrik-toft-simonsen

ORCID :

0000-0003-3070-807X

ResearcherID :

I-4263-2016

Présentation

Still working with Plant Biochemistry, and Biotechnology.

Our research is focused on understanding the biochemistry of terpenoids, especially smaller volatile terpenoids that are used for commercial products like perfumes and drugs. We also aim at generating novel plants (e.g. mosses) to produce these compounds at large scale. Our engineering efforts will employ techniques from the fields of synthetic biology, genomics, transcriptomics, proteomics, and metabolomics.Get in touch if you want to work or collaborate with us.

The work on mosses led to the establishment of Mosspiration Biotech ApS, and later Patch Botanics. Both are now closed, but the path was good. Lately, we have started a new company Tailwind Biotech that commercialises a patent on the use of machine learning to design DNA.

Specialties: Plant biochemistry, pharmacy, medicinal chemistry, Metabolomics, Entrepreneurship,

Publications

Article dans une revue (43)

Beyond Tanacetum cinerariifolium: Advances in Pyrethrins Biosynthesis and Prospects for Engineered Cell Factories Francisco Javier Astorga Ríos,Henrik Toft Simonsen Molecular Biotechnology, 2026, ⟨10.1007/s12033-025-01549-8⟩ Article dans une revue hal-05453963v1
The telomere‐to‐telomere genome of Sanicula chinensis unveils genetic underpinnings of low furanocoumarin diversity and content in one basal lineage of Apiaceae Weijun He,Donghua Hu,Miaoxian Guo,Bao Nie,Guangpu Zhanget al. The Plant Journal, 2025, 123 (1), ⟨10.1111/tpj.70311⟩ Article dans une revue hal-05147341v1
Genome sequencing of three Polyscias species reveals common features in terpene synthase gene family evolution in these species Mingzhou Bai,Xin Yang,David Lorence,Kenneth Wood,Natalie Iwanycki Ahlstrandet al. Plant Genome, 2025, 18 (1), ⟨10.1002/tpg2.20563⟩ Article dans une revue hal-04984426v1
Production of the monoterpenoid acid moiety of pyrethrins, trans-chrysanthemol, in the moss Physcomitrium patens Francisco Javier Astorga Ríos,Benoît Boachon,Henrik Toft Simonsen Plant Biotechnology Reports, 2025, ⟨10.1007/s11816-025-00980-2⟩ Article dans une revue hal-05072581v1
Tamariscol biosynthesis in Frullania tamarisci Corentin Conart,Henrik Toft Simonsen Phytochemistry, 2025, 229, pp.114301. ⟨10.1016/j.phytochem.2024.114301⟩ Article dans une revue hal-04820165v1
Characterization of microbial type terpene synthases from two liverworts Lophocolea bidentata and Nardia scalaris. Corentin Conart,Benjamin Svejdal Bejder,Mikkel Schardelmann,Rituraj Batth,Satish Kumar Kodiripakaet al. Plant Physiology and Biochemistry, 2025, pp.110031. ⟨10.1016/j.plaphy.2025.110031⟩ Article dans une revue hal-05072586v1
Production of human papillomavirus type 16 virus-like particles in Physcomitrella photobioreactors Paul Alexander Niederau,Maria Caroline Weilguny,Sarah Chamas,Caitlin Elizabeth Turney,Juliana Parsonset al. Plant Cell Reports, 2025, 44 (10), pp.216. ⟨10.1007/s00299-025-03602-x⟩ Article dans une revue hal-05267012v1
The telomere-to-telomere (T2T) genome of Peucedanum praeruptorum Dunn provides insights into the genome evolution and coumarin biosynthesis Mingzhou Bai,Sanjie Jiang,Shanshan Chu,Yangyang Yu,Dai Shanet al. GigaScience, 2024, 13, ⟨10.1093/gigascience/giae025⟩ Article dans une revue hal-04694744v1
Genome analysis of Chlorella vulgaris (CCAP 211/12) mutants provided insight into the molecular basis of chlorophyll deficiency Jianbo Jian,Pablo Torres-Montero,Mingzhou Bai,Yi Lu,Henrik Toft Simonsen Algal Research - Biomass, Biofuels and Bioproducts, 2024, 78, pp.103426. ⟨10.1016/j.algal.2024.103426⟩ Article dans une revue hal-04502869v1
Transcriptional and functional characterization in the terpenoid precursor pathway of the early land plant Physcomitrium patens A. Horn,Y. Lu,F. Astorga Ríos,Henrik Toft Simonsen,J. Becker Plant Biology, 2024, ⟨10.1111/plb.13741⟩ Article dans une revue hal-04820155v1
Integrating genomic and multiomic data for Angelica sinensis provides insights into the evolution and biosynthesis of pharmaceutically bioactive compounds Shiming Li,Tsan-Yu Chiu,Xin Jin,Dong Cao,Meng Xuet al. Communications Biology, 2023, 6 (1), pp.1198. ⟨10.1038/s42003-023-05569-5⟩ Article dans une revue hal-04502859v1
Heterologous Production of Artemisinin in &lt;em&gt;Physcomitrium patens&lt;/em&gt; by Direct in vivo Assembly of Multiple DNA Fragments Nur Ikram,Ali Zakariya,Mohd Saiman,Arman Kashkooli,Henrik Simonsen Bio-protocol , 2023, 13 (14), ⟨10.21769/BioProtoc.4719⟩ Article dans une revue hal-04503073v1
Current state, strategies, and perspectives in enhancing artemisinin production Ali Muhammad Zakariya,Mohd Zuwairi Saiman,Henrik Toft Simonsen,Nur Kusaira Khairul Ikram Phytochemistry Reviews, 2023, 23 (2), pp.283-320. ⟨10.1007/s11101-023-09897-6⟩ Article dans une revue hal-04820163v1
Dietary non-starch polysaccharides impair immunity to enteric nematode infection Angela Valente,Karen Jensen,Laura Myhill,Ling Zhu,Caroline Mentzelet al. BMC Biology, 2023, 21 (1), pp.138. ⟨10.1186/s12915-023-01640-z⟩ Article dans une revue hal-04503081v1
Lipidomes of Icelandic bryophytes and screening of high contents of polyunsaturated fatty acids by using lipidomics approach Yi Lu,Finnur Freyr Eiriksson,Margrét Thorsteinsdóttir,Nils Cronberg,Henrik Toft Simonsen Phytochemistry, 2023, 206, pp.113560. ⟨10.1016/j.phytochem.2022.113560⟩ Article dans une revue hal-04503125v1
Anti-Inflammatory Activity of Bryophytes Extracts in LPS-Stimulated RAW264.7 Murine Macrophages Raíssa Volpatto Marques,Stefania Enza Sestito,Frédéric Bourgaud,Sissi Miguel,Frédéric Cailottoet al. Molecules, 2022, 27 (6), pp.1940. ⟨10.3390/molecules27061940⟩ Article dans une revue hal-03652855v1
Anti-protozoal activity and metabolomic analyses of Cichorium intybus L. against Trypanosoma cruzi Miguel Peña-Espinoza,Yeambell Romero-Uzqueda,Angela Valente,Matthew de Roode,Henrik Toft Simonsenet al. International journal for parasitology. Drugs and drug resistance, 2022, 20 (6), pp.43-53. ⟨10.1016/j.ijpddr.2022.08.002⟩ Article dans une revue hal-04503144v1
Lipidomic analysis of moss species Bryum pseudotriquetrum and Physcomitrium patens under cold stress Yi Lu,Finnur Freyr Eiriksson,Margrét Thorsteinsdóttir,Henrik Toft Simonsen Plant-Environment Interactions, 2022, 3 (6), pp.254-263. ⟨10.1002/pei3.10095⟩ Article dans une revue hal-04503150v1
Bio-Guided Fractionation and Molecular Networking Reveal Fatty Acids to Be Principal Anti-Parasitic Compounds in Nordic Seaweeds Charlotte Smith Bonde,Louis Bornancin,Yi Lu,Henrik Toft Simonsen,María Martínez-Valladareset al. Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.674520⟩ Article dans une revue hal-04503384v1
Identification of anti-parasitic agents in Cichorium intybus. A Valente,M de Roode,M Peña-Espinoza,L Bornancin,Henrik Toft Simonsenet al. Planta Medica, 2021, 87, pp.1266. ⟨10.1055/s-0041-1736835⟩ Article dans une revue hal-04503348v1
Effects of extraction parameters on lipid profiling of mosses using UPLC-ESI-QTOF-MS and multivariate data analysis Yi Lu,Finnur Freyr Eiriksson,Margrét Thorsteinsdóttir,Henrik Toft Simonsen Metabolomics, 2021, 17 (11), pp.96. ⟨10.1007/s11306-021-01847-7⟩ Article dans une revue hal-04503355v1
Identification of compounds responsible for the anthelmintic effects of chicory (Cichorium intybus) by molecular networking and bio-guided fractionation Angela Valente,Matthew de Roode,Madeleine Ernst,Miguel Peña-Espinoza,Louis Bornancinet al. International journal for parasitology. Drugs and drug resistance, 2021, 15, pp.105-114. ⟨10.1016/j.ijpddr.2021.02.002⟩ Article dans une revue hal-04503390v1
Natural Products from Bryophytes: From Basic Biology to Biotechnological Applications Armin Horn,Arnaud Pascal,Isidora Lončarević,Raíssa Volpatto Marques,Yi Luet al. Critical Reviews in Plant Sciences, 2021, 40 (3), pp.191-217. ⟨10.1080/07352689.2021.1911034⟩ Article dans une revue hal-04503375v1
Collagenase and Tyrosinase Inhibitory Effect of Isolated Constituents from the Moss Polytrichum formosum Raíssa Volpatto Marques,Agnès Guillaumin,Ahmed Abdelwahab,Aleksander Salwinski,Charlotte Gotfredsenet al. Plants, 2021, 10 (7), pp.1271. ⟨10.3390/plants10071271⟩ Article dans une revue hal-04503369v1
Anthelmintic and metabolomic analyses of chicory (Cichorium intybus) identify an industrial by-product with potent in vitro antinematodal activity Miguel Peña-Espinoza,Angela Valente,Louis Bornancin,Henrik Toft Simonsen,Stig Thamsborget al. Veterinary Parasitology, 2020, 280, pp.109088. ⟨10.1016/j.vetpar.2020.109088⟩ Article dans une revue hal-04504044v1
Biosynthesis and Industrial Production of Androsteroids Rituraj Batth,Clément Nicolle,Ilenuta Simina Cuciurean,Henrik Toft Simonsen Plants, 2020, 9 (9), pp.1144. ⟨10.3390/plants9091144⟩ Article dans une revue hal-04504039v1
Stabilization of dhurrin biosynthetic enzymes from Sorghum bicolor using a natural deep eutectic solvent Camilla Knudsen,Krutika Bavishi,Ketil Mathiasen Viborg,Damian Paul Drew,Henrik Toft Simonsenet al. Phytochemistry, 2020, 170, pp.112214. ⟨10.1016/j.phytochem.2019.112214⟩ Article dans une revue hal-04504047v1
Cellulase and Macerozyme-PEG-mediated Transformation of Moss Protoplasts Rituraj Batth,Ilenuta Simina Cuciurean,Satish Kumar Kodiripaka,Sarah Rothman,Caroline Greisenet al. Bio-protocol , 2020, 10 (21), ⟨10.21769/BioProtoc.3782⟩ Article dans une revue hal-04503414v1
Connecting moss lipid droplets to patchoulol biosynthesis Anantha Peramuna,Hansol Bae,Carmen Quiñonero López,Arvid Fromberg,Bent Petersenet al. PLoS ONE, 2020, 15 (12), pp.e0243620. ⟨10.1371/journal.pone.0243620⟩ Article dans une revue hal-04504029v1
Exploring evolutionary theories of plant defence investment using field populations of the deadly carrot Karen Martinez-Swatson,Rasmus Kjøller,Federico Cozzi,Henrik Toft Simonsen,Nina Rønstedet al. Annals of Botany, 2020, 125 (5), pp.737-750. ⟨10.1093/aob/mcz151⟩ Article dans une revue hal-04504043v1
Thapsigargins and induced chemical defence in Thapsia garganica Karen Martinez-Swatson,Carmen Quiñonero-López,Madeleine Ernst,Nina Rønsted,Christopher James Barneset al. Chemoecology, 2020, 30 (5), pp.255-267. ⟨10.1007/s00049-020-00315-3⟩ Article dans une revue hal-04504033v1
Assessing Specialized Metabolite Diversity in the Cosmopolitan Plant Genus Euphorbia L. Madeleine Ernst,Louis-Félix Nothias,Justin van der Hooft,Ricardo Silva,C. Haris Saslis-Lagoudakiset al. Frontiers in Plant Science, 2019, 10, ⟨10.3389/fpls.2019.00846⟩ Article dans une revue hal-04504539v1
Anti-protozoal activity of extracts from chicory (Cichorium intybus) against Cryptosporidium parvum in cell culture Ian David Woolsey,Angela Valente,Andrew Williams,Stig Thamsborg,Henrik Simonsenet al. Scientific Reports, 2019, 9 (1), pp.20414. ⟨10.1038/s41598-019-56619-0⟩ Article dans une revue hal-04504048v1
Valuable Fatty Acids in Bryophytes—Production, Biosynthesis, Analysis and Applications Yi Lu,Finnur Freyr Eiriksson,Margrét Thorsteinsdóttir,Henrik Toft Simonsen Plants, 2019, 8 (11), pp.524. ⟨10.3390/plants8110524⟩ Article dans une revue hal-04504054v1
Biosynthesis of tovarol and other sesquiterpenoids in Thapsia laciniata Rouy Trine Bundgaard Andersen,Silas Anselm Rasmussen,Søren Brøgger Christensen,Henrik Toft Simonsen Phytochemistry, 2019, 157, pp.168-174. ⟨10.1016/j.phytochem.2018.10.027⟩ Article dans une revue hal-04504542v1
Valuable Fatty Acids in Bryophytes—Production, Biosynthesis, Analysis and Applications Yi Lu,Finnur Freyr Eiriksson,Margrét Thorsteinsdóttir,Henrik Toft Simonsen Plants, 2019, 8 (11), pp.524. ⟨10.3390/plants8110524⟩ Article dans une revue hal-04694762v1
Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin in Physcomitrella patens Nur Kusaira Binti Khairul Ikram,Arman Beyraghdar,Anantha Peramuna,Alexander R. van der Krol,Harro Bouwmeesteret al. Molecules, 2019, 24 (21), pp.3822. ⟨10.3390/molecules24213822⟩ Article dans une revue hal-04504534v1
In planta and in silico characterization of five sesquiterpene synthases from Vitis vinifera (cv. Shiraz) berries Bjørn Dueholm,Damian Drew,Crystal Sweetman,Henrik Simonsen Planta, 2018, 249 (1), pp.59-70. ⟨10.1007/s00425-018-2986-7⟩ Article dans une revue hal-04504526v1
Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review Miguel Peña-Espinoza,Angela Valente,Stig Thamsborg,Henrik Simonsen,Ulrik Boaset al. Parasites & Vectors, 2018, 11 (1), pp.475. ⟨10.1186/s13071-018-3012-4⟩ Article dans une revue hal-04694793v1
Physcomitrella patens, a versatile synthetic biology chassis Ralf Reski,Hansol Bae,Henrik Toft Simonsen Plant Cell Reports, 2018, 37 (10), pp.1409-1417. ⟨10.1007/s00299-018-2293-6⟩ Article dans une revue hal-04694797v1
In vivo assembly of DNA-fragments in the moss, Physcomitrella patens Brian Christopher King,Konstantinos Vavitsas,Nur Kusaira Binti Khairul Ikram,Josephine Schrøder,Lars B. Scharffet al. Scientific Reports, 2016, 6 (1), ⟨10.1038/srep25030⟩ Article dans une revue hal-02885735v1
Evolution of substrate recognition sites (SRSs) in cytochromes P450 from Apiaceae exemplified by the CYP71AJ subfamily Bjorn Dueholm,Celia Krieger,Damian Drew,Alexandre Olry,Tsunashi Kamoet al. BMC Evolutionary Biology, 2015, 15, ⟨10.1186/s12862-015-0396-z⟩ Article dans une revue hal-01475932v1
In vitro screening of Indian medicinal plants for antiplasmodial activity Henrik Toft Simonsen,Jesper Brændegaard Nordskjold,Ulla Wagner Smitt,Ulf Nyman,Pushpangadan Palpuet al. Journal of Ethnopharmacology, 2001, 74 (2), pp.195-204. ⟨10.1016/S0378-8741(00)00369-X⟩ Article dans une revue istex hal-04502853v1

Chapitre d'ouvrage (4)

Overexpression of Physcomitrium patens cell cycle regulators leads to larger gametophytes Anantha Peramuna,Carmen Quiñonero López,Francisco Javier Astorga Rios,Hansol Bae,Jonatan Ulrik Fangelet al. Bioactive Compounds in Bryophytes and Pteridophytes, 13 (1), Springer International Publishing, pp.4301, 2023, Reference Series in Phytochemistry, ⟨10.1038/s41598-023-31417-x⟩ Chapitre d'ouvrage hal-04503118v1
Extracts from the Liverwort Bazzania trilobata with Potential Dermo-cosmetic Properties Raíssa Volpatto Marques,Aleksander Salwinski,Kasper Enemark-Rasmussen,Charlotte Gotfredsen,Yi Luet al. Bioactive Compounds in Bryophytes and Pteridophytes, Springer International Publishing, pp.147-164, 2023, Reference Series in Phytochemistry, ⟨10.1007/978-3-031-23243-5_9⟩ Chapitre d'ouvrage hal-04246885v1
From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development Søren Brøgger Christensen,Henrik Toft Simonsen,Nikolai Engedal,Poul Nissen,Jesper Vuust Mølleret al. Progress in the Chemistry of Organic Natural Products 115, 115, Springer International Publishing, pp.59-114, 2021, Progress in the Chemistry of Organic Natural Products, ⟨10.1007/978-3-030-64853-4_2⟩ Chapitre d'ouvrage hal-04503397v1
Developments and Perspectives in Bryophyte Biotechnology in Sub-Saharan Africa Kenneth Yongabi Anchang,Henrik Toft Simonsen Biotechnology and Bioengineering, IntechOpen, 2019, ⟨10.5772/intechopen.81692⟩ Chapitre d'ouvrage hal-04504523v1

Brevet (1)

PRODUCTION OF TERPENES AND TERPENOIDS FIELD OF THE INVENTION Henrik Toft Simonsen,Anantha Peramuna France, Patent n° : WO2019057258. 2019 Brevet hal-04504027v1