Ibai Valverde Chargé de recherches CNRS

Publications

Article dans une revue (22)

Convergent Synthesis of Template‐Assembled Synthetic G‐Quartets (TASQs) Used as Biomimetic and Multivalent G‐Quadruplex (G4) Ligands Sandy Raevens,Cécile Desingle,Marc Pirrotta,Francesco Rota Sperti,Andréa Pieriet al. Chemistry - A European Journal, 2025, pp.e03002. ⟨10.1002/chem.202503002⟩ Article dans une revue hal-05384162v1
Photoactivatable, Biomimetic Ligand photoMultiTASQ Traps DNA/RNA G-Quadruplexes and Their Protein Binding Partners Sandy Raevens,Yehuda Danino,Cécile Desingle,Francesco Rota Sperti,Marc Pirrottaet al. ACS Bio & Med Chem Au, 2025, ⟨10.1021/acsbiomedchemau.5c00162⟩ Article dans une revue hal-05343353v1
Fluorescence Detection of DNA/RNA G‐Quadruplexes (G4s) by Twice‐as‐Smart Ligands Jiri Ledvinka,Francesco Rota Sperti,Gabor Paragi,Marc Pirrotta,Nicolas Chéronet al. ChemMedChem, 2025, ⟨10.1002/cmdc.202400829⟩ Article dans une revue hal-05018355v1
The multivalent G-quadruplex (G4)-ligands MultiTASQs allow for versatile click chemistry-based investigations Francesco Rota Sperti,Jérémie Mitteaux,Joanna Zell,Angélique Pipier,Ibai E Valverdeet al. RSC Chemical Biology, 2023, 4 (7), pp.456-465. ⟨10.1039/D3CB00009E⟩ Article dans une revue hal-04154672v1
Side-by-side comparison of G-quadruplex (G4) capture efficiency of the antibody BG4 versus the small-molecule ligands TASQs Yilong Feng,Zexue He,Zhenyu Luo,Francesco Rota Sperti,Ibai E. Valverdeet al. iScience, 2023, 26 (6), pp.106846. ⟨10.1016/j.isci.2023.106846⟩ Article dans une revue hal-04110844v1
Theranostics of Primary Prostate Cancer: beyond PSMA and GRP-R Romain Schollhammer,Marie-Laure Quintyn Ranty,Henri de Clermont Gallerande,Florine Cavelier,Ibai E Valverdeet al. Cancers, 2023, 15 (8), pp.2345. ⟨10.3390/cancers15082345⟩ Article dans une revue hal-04075693v1
A Modular One-Pot Strategy for the Synthesis of Heterobivalent Tracers Thibaud Bailly,Sacha Bodin,Victor Goncalves,Franck Denat,Clément Morgatet al. ACS Medicinal Chemistry Letters, In press, ⟨10.1021/acsmedchemlett.3c00057⟩ Article dans une revue hal-04087376v1
Click-Chemistry-Based Biomimetic Ligands Efficiently Capture G-Quadruplexes &lt;i&gt;In Vitro&lt;/i&gt; and Help Localize Them at DNA Damage Sites in Human Cells Francesco Rota Sperti,Baptiste Dupouy,Jérémie Mitteaux,Angélique Pipier,Marc Pirrottaet al. JACS Au, 2022, 2, pp.1588 - 1595. ⟨10.1021/jacsau.2c00082⟩ Article dans une revue hal-03738327v1
1,5-Disubstituted 1,2,3-Triazoles as Amide Bond Isosteres Yield Novel Tumor-Targeting Minigastrin Analogs Nathalie M. Grob,Roger Schibli,Martin Béhé,Ibai Valverde,Thomas L. Mindt ACS Medicinal Chemistry Letters, In press, ⟨10.1021/acsmedchemlett.0c00636⟩ Article dans une revue hal-03178434v1
Biomimetic, Smart, and Multivalent Ligands for G-Quadruplex Isolation and Bioorthogonal Imaging Francesco Rota Sperti,Thibaut Charbonnier,Pauline Lejault,Joanna Zell,Claire Bernhardet al. ACS Chemical Biology, 2021, 16 (5), pp.905 - 914. ⟨10.1021/acschembio.1c00111⟩ Article dans une revue hal-03321466v1
Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity Eirinaios Vrettos,Ibai E. Valverde,Alba Mascarin,Patrick Pallier,Linda Cerofoliniet al. Chemistry - A European Journal, 2020, 26 (47), pp.10690-10694. ⟨10.1002/chem.202000924⟩ Article dans une revue hal-03007010v1
Synthetic routes to novel fluorogenic pyronins and silicon analogs with far-red spectral properties and enhanced aqueous stability Garance Dejouy,Kévin Renault,Ibai E. Valverde,Anthony Romieu Dyes and Pigments, 2020, 180, pp.108496. ⟨10.1016/j.dyepig.2020.108496⟩ Article dans une revue hal-03007352v1
Synthesis and evaluation of zirconium-89 labelled and long-lived GLP-1 receptor agonists for PET imaging Christian Borch Jacobsen,René Raavé,Marie Østergaard Pedersen,Pierre Adumeau,Mathieu Moreauet al. Nuclear Medicine and Biology, 2020, 82-83, pp.49-56. ⟨10.1016/j.nucmedbio.2019.11.006⟩ Article dans une revue hal-03004102v1
Fluorogenic Enzyme-Triggered Domino Reactions Producing Quinoxalin-2(1 H)-one-based Heterocycles Garance Dejouy,Kévin Renault,Quentin Bonnin,Arnaud Chevalier,Cédric Michaudetet al. Organic Letters, 2020, 22 (16), pp.6494-6499. ⟨10.26434/chemrxiv.12613862.v1⟩ Article dans une revue hal-03016953v1
Fluorogenic Enzyme-Triggered Domino Reactions Producing Quinoxalin-2(1H)-one-based Heterocycles Garance Dejouy,Kévin Renault,Quentin Bonnin,Arnaud Chevalier,Cédric Michaudetet al. Organic Letters, 2020, 22 (16), pp.6494-6499. ⟨10.1021/acs.orglett.0c02287⟩ Article dans une revue hal-03006821v1
The scope of application of macrocyclic polyamines beyond metal chelation Pauline Lejault,Katerina Duskova,Claire Bernhard,Ibai E. Valverde,Anthony Romieuet al. European Journal of Organic Chemistry, 2019, 2019 (36), pp.6146-6157. ⟨10.1002/ejoc.201900870⟩ Article dans une revue hal-02268694v2
Quest for novel fluorogenic xanthene dyes: Synthesis, spectral properties and stability of 3-imino-3H-xanthen-6-amine (pyronin) and its silicon analog Anthony Romieu,Garance Dejouy,Ibai Valverde Tetrahedron Letters, 2018, 59 (52), pp.4574-4581. ⟨10.1016/j.tetlet.2018.11.031⟩ Article dans une revue hal-02168864v1
Synthesis, stability and spectral behavior of fluorogenic sulfone-pyronin and sulfone-rosamine dyes Garance Dejouy,Myriam Laly,Ibai Valverde,Anthony Romieu Dyes and Pigments, 2018, 159, pp.262-274. ⟨10.1016/j.dyepig.2018.06.026⟩ Article dans une revue hal-02168863v1
Amide-to-triazole switch vs. in vivo NEP-inhibition approaches to promote radiopeptide targeting of GRPR-positive tumors Theodosia Maina,Aikaterini Kaloudi,Ibai E. Valverde,Thomas L. Mindt,Berthold A. Nock Nuclear Medicine and Biology, 2017, 52, pp.57 - 62. ⟨10.1016/j.nucmedbio.2017.06.001⟩ Article dans une revue hal-01562008v1
Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations. Ibai E Valverde,Fabien Lecaille,Gilles Lalmanach,Vincent Aucagne,Agnès F Delmas Angewandte Chemie International Edition, 2012, 51 (3), pp.718-22. ⟨10.1002/anie.201107222⟩ Article dans une revue istex hal-00726293v1
Towards the simplification of protein synthesis: iterative solid-supported ligations with concomitant purifications. Vincent Aucagne,Ibai E Valverde,Philippe Marceau,Mathieu Galibert,Nabil Dendaneet al. Angewandte Chemie International Edition, 2012, 51 (45), pp.11320-4. ⟨10.1002/anie.201206428⟩ Article dans une revue istex hal-00748170v1
Click a la carte: robust semi-orthogonal alkyne protecting groups for multiple successive azide/alkyne cycloadditions Ibai E. Valverde,Agnès F. Delmas,Vincent Aucagne Tetrahedron, 2009, 65 (36), pp.7597-7602. ⟨10.1016/j.tet.2009.06.093⟩ Article dans une revue istex hal-00525398v1

Brevet (1)

Biomimetic G-quartet compounds David Monchaud,Pauline Lejault,Ibai E. Valverde,Francesco Rota Sperti France, Patent n° : EP3889155A1. 2021 Brevet hal-03372659v1

Pré-publication, Document de travail (3)

The multivalent G-quadruplex (G4)-ligands MultiTASQs allow for versatile click chemistry-based investigations Francesco Rota Sperti,Jeremie Mitteaux,Joanna Zell,Angelique Pipier,Ibai Valverdeet al. 2022 Pré-publication, Document de travail hal-03836044v1
Chemo- versus immuno-precipitation of G-quadruplex-DNA (G4DNA): a direct comparison of the efficiency of the antibody BG4 versus the small-molecule ligands TASQs for G4 affinity capture Yilong Feng,Zhenyu Luo,Francesco Rota Sperti,Ibai Valverde,Wenli Zhanget al. 2022 Pré-publication, Document de travail hal-03836040v1
Biomimetic, smart and multivalent ligands for G-quadruplex isolation and bioorthogonal imaging Francesco Rota Sperti,Thibaut Charbonnier,Pauline Lejault,Joanna Zell,Claire Bernhardet al. 2020 Pré-publication, Document de travail hal-03086822v1

Thèse (1)

La multi-ligation triazole : Développement de nouveaux outils pour la synthèse de mimes de protéines par cycloadditions successives Ibai Valverde Chimie. Universite d'Orléans, 2010. Français. ⟨NNT : ⟩ Thèse tel-01157275v1