Ignacio Caballero

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Publications

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The immune response modulated by inoculation of commensal bacteria at birth impacts the gut microbiota and prevents Salmonella colonization

Florent Kempf , Rosanna Drumo , Anne-Marie Chaussé , Pierrette Menanteau , Tereza Kubasova et al.
Gut microbes, 2025, 17 (1), pp.2474151. ⟨10.1080/19490976.2025.2474151⟩
Article dans une revue hal-05004820 v1
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Cystic fibrosis alters the structure of the olfactory epithelium and the expression of olfactory receptors affecting odor perception

Ignacio Caballero-Posadas , Yvon Mbouamboua , Susanne Weise , Raquel López-Gálvez , Marie Couralet et al.
Science Advances , 2025, 11 (9), pp.eads1568. ⟨10.1126/sciadv.ads1568⟩
Article dans une revue hal-05006969 v1
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Influenza A virus in dairy cattle: infection biology and potential mammary gland-targeted vaccines

Rodrigo Prado Martins , Daniel Marc , Pierre Germon , Sascha Trapp , Ignacio Caballero-Posadas
NPJ vaccines, 2025, 10 (1), pp.8. ⟨10.1038/s41541-025-01063-7⟩
Article dans une revue (article de synthèse) hal-04902315 v1

Perinatal dysfunction of innate immunity in cystic fibrosis

Florian Jaudas , Florian Bartenschlager , Bachuki Shashikadze , Gianluca Santamaria , Daniel Reichart et al.
Science Translational Medicine, 2025, 17 (782), pp.eadk9145. ⟨10.1126/scitranslmed.adk9145⟩
Article dans une revue hal-04988316 v1
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Exploring type I interferon pathway: virulent vs. attenuated strain of African swine fever virus revealing a novel function carried by MGF505-4R

Juliette Dupré , Mireille Le Dimna , Evelyne Hutet , Pascal Dujardin , Aurore Fablet et al.
Frontiers in Immunology, 2024, 15, pp.1358219. ⟨10.3389/fimmu.2024.1358219⟩
Article dans une revue anses-04504013 v1
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The gut microbiota and its metabolite butyrate shape metabolism and antiviral immunity along the gut-lung axis in the chicken

Vincent Saint-Martin , Vanaïque Guillory , Mélanie Chollot , Isabelle Fleurot , Emmanuel Kut et al.
Communications Biology, 2024, 7 (1), pp.1185. ⟨10.1038/s42003-024-06815-0⟩
Article dans une revue hal-04720201 v1
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The MIR34B/C genomic region contains multiple potential regulators of multiciliogenesis

Amélie Cavard , Elisa Redman , Olivier Mercey , Sophie Abelanet , Magali Plaisant et al.
FEBS Letters, 2023, 597 (12), pp.1623 - 1637. ⟨10.1002/1873-3468.14630⟩
Article dans une revue hal-04169595 v1
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A pig model of chronic hepatitis E displaying persistent viremia and a downregulation of innate immune responses in the liver

Nancy León-Janampa , Ignacio Caballero-Posadas , Céline Barc , François Darrouzain , Alain Moreau et al.
Hepatology Communications, 2023, 7 (11), pp.e0274. ⟨10.1097/HC9.0000000000000274⟩
Article dans une revue hal-04332121 v1
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New Insights in the Interplay Between African Swine Fever Virus and Innate Immunity and Its Impact on Viral Pathogenicity

Abraham Ayanwale , Sascha Trapp , Rodrigo Guabiraba , Ignacio Caballero-Posadas , Ferdinand Roesch
Frontiers in Microbiology, 2022, 13, 9 p. ⟨10.3389/fmicb.2022.958307⟩
Article dans une revue (article de synthèse) hal-03738722 v1
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TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium

Isabelle Fleurot , Raquel López-Gálvez , Pascal Barbry , Antoine Guillon , Mustapha Si-Tahar et al.
Journal of Cystic Fibrosis, 2022, 21 (2), pp.e117-e121. ⟨10.1016/j.jcf.2021.08.002⟩
Article dans une revue hal-03556846 v1
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Airway administration of flagellin regulates the inflammatory response to Pseudomonas aeruginosa

Raquel López-Gálvez , Isabelle Fleurot , Pablo Chamero , Sascha Trapp , Olivier Michel et al.
American Journal of Respiratory Cell and Molecular Biology, 2021, 65 (4), pp.378-389. ⟨10.1165/rcmb.2021-0125OC⟩
Article dans une revue hal-03258174 v1
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Evidence of early increased sialylation of airway mucins and defective mucociliary clearance in CFTR-deficient piglets

Ignacio Caballero , Bélinda Ringot-Destrez , Mustapha Si-Tahar , Pascal Barbry , Antoine Guillon et al.
Journal of Cystic Fibrosis, 2021, 20 (1), pp.173-182. ⟨10.1016/j.jcf.2020.09.009⟩
Article dans une revue hal-02967168 v1
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Where Is the Cystic Fibrosis Transmembrane Conductance Regulator?

Pascal Barbry , Brice Marcet , Ignacio Caballero
American Journal of Respiratory and Critical Care Medicine, 2021, 203 (10), pp.1214 - 1216. ⟨10.1164/rccm.202012-4434ED⟩
Article dans une revue hal-03264909 v1
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Intrinsic alterations in peripheral neutrophils from cystic fibrosis newborn piglets

Deborah Brea , Laura Soler , Isabelle Fleurot , Sandrine Melo , Claire Chevaleyre et al.
Journal of Cystic Fibrosis, 2020, 19 (5), pp.830-836. ⟨10.1016/j.jcf.2020.02.016⟩
Article dans une revue hal-03012482 v1
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CFTR-deficient pigs display alterations of bone microarchitecture and composition at birth

Julien Braux , Marie-Laure Jourdain , Christine Guillaume , Valérie Untereiner , Olivier Piot et al.
Journal of Cystic Fibrosis, 2020, 19 (3), pp.466-475. ⟨10.1016/j.jcf.2019.10.023⟩
Article dans une revue hal-02406264 v1
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Tetrafunctional Block Copolymers Promote Lung Gene Transfer in Newborn Piglets

Ignacio Caballero , Mickaël Riou , Océane Hacquin , Claire Chevaleyre , Céline Barc et al.
Molecular Therapy - Nucleic Acids, 2019, 16, pp.186-193. ⟨10.1016/j.omtn.2019.02.016⟩
Article dans une revue inserm-02080870 v1
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Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures

Sandra Ruiz Garcia , Marie Deprez , Kevin Lebrigand , Amelie Cavard , Agnès Paquet et al.
Development (Cambridge, England), 2019, 146 (20), 17p. ⟨10.1242/dev.177428⟩
Article dans une revue hal-02628140 v1
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Generation of a Stable Transgenic Swine Model Expressing a Porcine Histone 2B-eGFP Fusion Protein for Cell Tracking and Chromosome Dynamics Studies

Renan B. Sper , Sehwon Koh , Xia Zhang , Sean Simpson , Bruce Collins et al.
PLoS ONE, 2017, 12 (1), 24 p. ⟨10.1371/journal.pone.0169242⟩
Article dans une revue hal-01607549 v1
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Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol

Ignacio Caballero-Posadas , James Boyd , Carmen Alminana-Brines , Javier A. Sánchez-López , Shaghayegh Basatvat et al.
Scientific Reports, 2017, 7, 10 p. ⟨10.1038/srep40981⟩
Article dans une revue hal-01594679 v1

Interleukin-1 receptor antagonist mediates toll-like receptor 3-induced inhibition of trophoblast adhesion to endometrial cells in vitro

M. Montazeri , J.A. Sanchez-Lopez , Ignacio Caballero , N. Maslehat Lay , S. Elliott et al.
Human Reproduction, 2016, 31 (9), pp.2098-2107. ⟨10.1093/humrep/dew171⟩
Article dans une revue hal-02634561 v1
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The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection.

Claire Chevaleyre , Mickaël Riou , Deborah Brea , Clarisse Vandebrouck , Céline Barc et al.
PLoS ONE, 2016, 11 (12), pp.e0168577. ⟨10.1371/journal.pone.0168577⟩
Article dans une revue hal-01437131 v1

Activation of Toll-like receptor 3 reduces actin polymerization and adhesion molecule expression in endometrial cells, a potential mechanism for viral-induced implantation failure

M. Montazeri , J.A. Sanchez-Lopez , Ignacio Caballero-Posadas , N. Maslehat Lay , S. Elliott et al.
Human Reproduction, 2015, 30 (4), pp.893-905. ⟨10.1093/humrep/deu359⟩
Article dans une revue hal-01171121 v1
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Computed tomography (CT) scanning facilitates early identification of neonatal cystic fibrosis piglets

Antoine Guillon , Claire Chevaleyre , Céline Barc , Mustapha Berri , Hans Adriaensen et al.
PLoS ONE, 2015, 10 (11), pp.1-12. ⟨10.1371/journal.pone.0143459⟩
Article dans une revue hal-01594228 v1
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The battle of the sexes starts in the oviduct: modulation of oviductal transcriptome by X and Y-bearing spermatozoa

Carmen Alminana , Ignacio Caballero , Paul Roy Heath , Saeedeh Maleki-Dizaji , Inmaculada Parrilla et al.
BMC Genomics, 2014, 15, pp.1-11. ⟨10.1186/1471-2164-15-293⟩
Article dans une revue hal-02635235 v1

Local Activation of Uterine Toll-Like Receptor 2 and 2/6 Decreases Embryo Implantation and Affects Uterine Receptivity in Mice

Javier Arturo Sanchez-Lopez , Ignacio Caballero , Mehrnaz Montazeri , Nasim Maslehat , Sarah Elliott et al.
Biology of Reproduction, 2014, 90 (4), pp.1-13. ⟨10.1095/biolreprod.113.115253⟩
Article dans une revue hal-02637664 v1
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Human Trophoblast Cells Modulate Endometrial Cells Nuclear Factor kappa B Response to Flagellin In Vitro

Ignacio Caballero , Sumiah Al Ghareeb , Shaghayegh Basatvat , Javier A. Sánchez-López , Mehrnaz Montazeri et al.
PLoS ONE, 2013, 8 (1), pp.1-10. ⟨10.1371/journal.pone.0039441⟩
Article dans une revue hal-02646437 v1

The Effect of Glycerol Concentrations on the Post-thaw In Vitro Characteristics of Cryopreserved Sex-sorted Boar Spermatozoa

I. Parrilla , D. del Olmo , Ignacio Caballero , T. Tarantini , C. Cuello et al.
Reproduction in Domestic Animals, 2012, 47 (6), pp.965 - 974. ⟨10.1111/j.1439-0531.2012.02000.x⟩
Article dans une revue istex hal-02647199 v1

Seminal Plasma Proteins as Modulators of the Sperm Function and Their Application in Sperm Biotechnologies

Ignacio Caballero , I. Parrilla , Carmen Alminana , D. del Olmo , J. Roca et al.
Reproduction in Domestic Animals, 2012, 47 (Suppl.3), pp.12-21. ⟨10.1111/j.1439-0531.2012.02028.x⟩
Article dans une revue (article de synthèse) istex hal-02649909 v1

Influence of storage time on functional capacity of flow cytometrically sex-sorted boar spermatozoa

Ignacio Caballero-Posadas , Inmaculada Parrilla , Juan Vazquez , Maria Gil , Ignacio Caballero et al.
Theriogenology, 2005, 64 (1), pp.86-98. ⟨10.1016/j.theriogenology.2004.11.004⟩
Article dans une revue istex hal-03449663 v1

Comparative Effects of Autologous and Homologous Seminal Plasma on the Viability of Largely Extended Boar Spermatozoa

Ignacio Caballero-Posadas , Jm Vazquez , F Centurión , H Rodríguez-Martinez , I Parrilla et al.
Reproduction in Domestic Animals, 2004, 39 (5), pp.370-375. ⟨10.1111/j.1439-0531.2004.00530.x⟩
Article dans une revue istex hal-03449115 v1

A new immunosuppressed pig model to study chronic Hepatitis E infection and its impact on host innate immune responses

Julien Marlet , Nancy León Janampa , Ignacio Caballero-Posadas , Céline Barc , François Darrouzain et al.
Journées d'Animation Scientifique de la FéRI 2022 - FéRi Scientific Days 2022, Fédération de Recherche en Infectiologie (FéRI), Centre Val de Loire, Jul 2022, Joué-Lès-Tours, France
Communication dans un congrès hal-03735443 v1

A new immunosuppressed pig model to study chronic Hepatitis E infection and the genetic viral diversity

Nancy León Janampa , Ignacio Caballero-Posadas , Céline Barc , François Darrouzain , Philippe Gatault et al.
17. Congrès national de la SFM - Microbes 2022, Société Française de Microbiologie, Oct 2022, Montpellier, France
Communication dans un congrès hal-03908226 v1

Faecal gut microbiota composition determines susceptibility to Salmonella Enteritidis primo-colonization

Florent Kempf , Pierrette Menanteau , Ivan Rychlik , Rosanna Drumo , Ignacio Caballero et al.
OneHealth EJP Annual Scientific meeting 2020 - Online, May 2020, Pragues - Online, Czech Republic
Communication dans un congrès hal-03186758 v1

Novel approaches boosting innate immunity against <em>Pseudomonas aeruginosa</em>

Isabelle Fleurot , Mickael Riou , Claire Chevaleyre , Sandrine Melo , Michel Olivier et al.
15. Congrès National de la Société Française de Microbiologie (SFM), Société Française de Microbiologie (SFM). FRA., Sep 2019, Paris, France. pp.436
Communication dans un congrès hal-02736599 v1

The cystic fibrosis pig model : advantages and disadvantages

Ignacio Caballero-Posadas
Journée thématique Biotechnocentre « Modèles animaux et leurs alternatives: quel avenir ? », Jun 2016, Joué-les-Tours, France
Communication dans un congrès hal-02792567 v1

Closing remarks

Ignacio Caballero
International Conference on Cystic fibrosis: contribution of animal models to therapeutic development, Nov 2015, Tours, France
Communication dans un congrès hal-02792244 v1

The European CF pig model: ups, downs and perspectives

Ignacio Caballero
International Conference on Cystic fibrosis: contribution of animal models to therapeutic development, Nov 2015, Tours, France
Communication dans un congrès hal-02792552 v1

Neutrophils in cystic fibrosis. Are they intrinsically defective?

Deborah Brea , Laura Soler Vasco , Antoine Guillon , Claire C. Chevaleyre , Celine Barc et al.
Journées d'Animation Scientifique de la Fédération de Recherche d'Infectiologie (FéRI), Oct 2015, Orléans, France. 2 p
Communication dans un congrès hal-02799967 v1

Contribution of computed tomography (CT) scan to extend the lifespan of a porcine CFTR - / - model

Ignacio Caballero , Antoine Guillon , Celine Barc , El Mostafa Berri , Claire C. Chevaleyre et al.
8. European CF Young Investigator Meeting, Feb 2014, Paris, France. 19 Diapositives
Communication dans un congrès hal-02793962 v1

Développement d'un modèle d'infection respiratoire aiguë à Pseudomonas aeruginosa chez le porc

Mickaël Riou , Claire C. Chevaleyre , Deborah Brea , Celine Barc , Clarisse Vandebrouck et al.
34. Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI), Nov 2014, Paris, France
Communication dans un congrès hal-02799765 v1

Flagellin treatment: an immunomodulation strategy for controllong swine influenza infection

Elaa Chkhaydem , Isabelle Fleurot , Vanaïque Guillory , Emmanuel Kut , Céline Barc et al.
9. International Influenza Meeting:" From bench to bedside", Sep 2024, Münster (DE), Germany.
Poster de conférence hal-04913467 v1

Dynamique d'expression du virus de la peste porcine africaine et impact sur les voies de l'immunité innée et la virulence

Aurélien Leroy , Chloé Styranec , Vanaïque Guillory , Isabelle Fleurot , Marie-Frédérique Le Potier et al.
XXVèmes Journées Francophones de Virologie, Apr 2023, Paris, France. Virologie, 27 (2), pp.77-78, 2023
Poster de conférence anses-04471667 v1
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Modeling Hepatitis E infection in immunocompromised patients using a new pig model

Nancy León Janampa , Céline Barc , François Darrouzain , Philippe Gatault , Mickaël Riou et al.
17. International Symposium on Viral Hepatitis and Liver Diseases (ISVHLD), Jun 2021, Taipei, Taiwan. 345
Poster de conférence hal-03388900 v1

CFTR-KO pigs exhibit altered bone microarchitecture at birth

F. Velard , Marie Laure Jourdain , Ignacio Caballero-Posadas , Nathalie Winter , Mustapha Si-Tahar et al.
32. Annual North American Cystic Fibrosis Conference, Oct 2018, Denver, United States. WILEY, Pediatric Pulmonology, 53 (S2), 2018
Poster de conférence hal-02734331 v1

Flagellin pre-stimulation modulates the immune response to pathogens in pig airway epithelial cells

Isabelle Fleurot , Sandrine Melo , Michel Olivier , Claire Chevaleyre , Christophe Carnoy et al.
11. Symposium of the French Domestic Animal Immunology Network (IAD 2018), Mar 2018, Tours, France. , 56 p., 2018
Poster de conférence hal-02736823 v1

CFTR-Deficient Pigs Have Altered Bone Microarchitecture and Elevated Closed Cortical Porosity at Birth

Frédéric Velard , Marie Laure Jourdain , Ignacio Caballero-Posadas , Nathalie Winter , Mustapha Si-Tahar et al.
International Conference of the American-Thoracic-Society (ATS 2018), May 2018, San Diego, United States. AMER THORACIC SOC, American Journal of Respiratory and Critical Care Medicine, 197, 2018
Poster de conférence hal-02734272 v1

Le modèle européen de porc CF : un modèle unique pour décrypter les altérations de glycosylation des mucines pulmonaires

B. Ringot-Destrez , Ignacio Caballero , Mustapha Si-Tahar , P. Barbry , A. Guillon et al.
17. Colloque des jeunes chercheurs Vaincre la Mucoviscidose, Feb 2016, Paris, France. , 2016
Poster de conférence hal-02800304 v1

Toll-like Receptor 9 Activation in Trophoblast-Endometrium Cross-talk

N. Maslehat Lay , J. Sanchez-Lopez , Mehrnaz Montazeri , Ignacio Caballero , S. Elliott et al.
49. Annual meeting of the Society for the Study of Reproduction SSR 2016, Jul 2016, San Diego, United States. , 2016
Poster de conférence hal-02799318 v1

The pig as a model to determine the origins of cystic fibrosis lung disease

Ignacio Caballero , Antoine Guillon , Celine Barc , Isabelle Lantier , Mustapha M. Berri et al.
COST Action BM1308 “Sharing Advances in Large Animal Models” (SALAAM), Dec 2015, Poznan, Poland. , 2015
Poster de conférence hal-02800785 v1

Development of a functional in vitro cell system to test the role of Tribbles-2 in embryo implantation

Shaghayegh Basatvat , Ignacio Caballero , Mehrnaz Montazeri , Javier Arturo Sanchez-Lopez , N. Maslehat Lay et al.
Tribbles Pseudokinases on the Crossroads of Metabolism, Cancer, Immunity and Development, Apr 2014, Budapest, Hungary. , 2015
Poster de conférence hal-02793491 v1

The pig as a model for the study of the early immune response to <em>Pseudomonas Aeruginosa</em>

Mustapha M. Berri , Mickaël Riou , Celine Barc , Deborah Brea , Claire C. Chevaleyre et al.
Swine in Biomedical Research Conference, Jul 2014, Raleigh, United States. 2014
Poster de conférence hal-02795088 v1

Contribution of computed tomography (CT) scan to extend the lifespan of a porcine CFTR - / - model

Ignacio Caballero , Antoine Guillon , Celine Barc , El Mostafa Berri , Claire C. Chevaleyre et al.
8. European CF Young Investigator Meeting, Feb 2014, Paris, France. 2014
Poster de conférence hal-02798139 v1

Développement d'un modèle d'infection respiratoire aiguë à Pseudomonas aeruginosa chez le porc

Mickaël Riou , Claire C. Chevaleyre , Deborah Brea , Celine Barc , Clarisse Vandebrouck et al.
3. Journées d'Animation Scientifique, Jun 2014, Parcay Meslay, France. 2014
Poster de conférence hal-02801096 v1

Adjustments of glycerol concentration for improving the post-thaw quality of sex sorted boar spermatozoa

I. Parrilla , D. del Olmo , Ignacio Caballero , T. Tarantini , C. Cuello et al.
11. International Congress of the Spanish Association for Animal Reproduction (AERA), Jun 2012, Cordoba, Spain. , Reproduction in Domestic Animals, 47 (suppl.3), 2012
Poster de conférence hal-02745246 v1

Post-thaw quality of boar semen frozen at low sperm concentration

I. Parrilla , D. del Olmo , Ignacio Caballero , T. Tarantini , M. A. Gil et al.
15. Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR), Sep 2011, Antalya, Turkey. , Reproduction in Domestic Animals, 46 (suppl.3), 2011, ⟨10.1111/j.1439-0531.2011.01839.x⟩
Poster de conférence hal-02745244 v1
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Habilitation à diriger des recherches Ignacio Caballero

Ignacio Caballero-Posadas
Veterinary medicine and animal Health. Université François Rabelais - Tours, 2020
HDR tel-04181484 v1