Ignacio Caballero

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Publications

Article dans une revue (31)

Cystic fibrosis alters the structure of the olfactory epithelium and the expression of olfactory receptors affecting odor perception Ignacio Caballero-Posadas,Yvon Mbouamboua,Susanne Weise,Raquel López-Gálvez,Marie Couraletet al. Science Advances , 2025, 11 (9), pp.eads1568. ⟨10.1126/sciadv.ads1568⟩ Article dans une revue hal-05006969v1
Influenza A virus in dairy cattle: infection biology and potential mammary gland-targeted vaccines Rodrigo Prado Martins,Daniel Marc,Pierre Germon,Sascha Trapp,Ignacio Caballero-Posadas NPJ vaccines, 2025, 10 (1), pp.8. ⟨10.1038/s41541-025-01063-7⟩ Article dans une revue (article de synthèse) hal-04902315v1
Flagellin nebulization enhances respiratory immune responses in the porcine model Mara Baldry,Ignacio Caballero,Lisette Ruuls,Delphine Cayet,Yasmine Zeroualet al. iScience, 2025, 28 (12), pp.114218. ⟨10.1016/j.isci.2025.114218⟩ Article dans une revue hal-05390732v1
Perinatal dysfunction of innate immunity in cystic fibrosis Florian Jaudas,Florian Bartenschlager,Bachuki Shashikadze,Gianluca Santamaria,Daniel Reichartet al. Science Translational Medicine, 2025, 17 (782), pp.eadk9145. ⟨10.1126/scitranslmed.adk9145⟩ Article dans une revue hal-04988316v1
The immune response modulated by inoculation of commensal bacteria at birth impacts the gut microbiota and prevents Salmonella colonization Florent Kempf,Rosanna Drumo,Anne-Marie Chaussé,Pierrette Menanteau,Tereza Kubasovaet al. Gut microbes, 2025, 17 (1), pp.2474151. ⟨10.1080/19490976.2025.2474151⟩ Article dans une revue hal-05004820v1
The gut microbiota and its metabolite butyrate shape metabolism and antiviral immunity along the gut-lung axis in the chicken Vincent Saint-Martin,Vanaïque Guillory,Mélanie Chollot,Isabelle Fleurot,Emmanuel Kutet al. Communications Biology, 2024, 7 (1), pp.1185. ⟨10.1038/s42003-024-06815-0⟩ Article dans une revue hal-04720201v1
Exploring type I interferon pathway: virulent vs. attenuated strain of African swine fever virus revealing a novel function carried by MGF505-4R Juliette Dupré,Mireille Le Dimna,Evelyne Hutet,Pascal Dujardin,Aurore Fabletet al. Frontiers in Immunology, 2024, 15, pp.1358219. ⟨10.3389/fimmu.2024.1358219⟩ Article dans une revue anses-04504013v1
The MIR34B/C genomic region contains multiple potential regulators of multiciliogenesis Amélie Cavard,Elisa Redman,Olivier Mercey,Sophie Abelanet,Magali Plaisantet al. FEBS Letters, 2023, 597 (12), pp.1623 - 1637. ⟨10.1002/1873-3468.14630⟩ Article dans une revue hal-04169595v1
A pig model of chronic hepatitis E displaying persistent viremia and a downregulation of innate immune responses in the liver Nancy León-Janampa,Ignacio Caballero-Posadas,Céline Barc,François Darrouzain,Alain Moreauet al. Hepatology Communications, 2023, 7 (11), pp.e0274. ⟨10.1097/HC9.0000000000000274⟩ Article dans une revue hal-04332121v1
New Insights in the Interplay Between African Swine Fever Virus and Innate Immunity and Its Impact on Viral Pathogenicity Abraham Ayanwale,Sascha Trapp,Rodrigo Guabiraba,Ignacio Caballero-Posadas,Ferdinand Roesch Frontiers in Microbiology, 2022, 13, 9 p. ⟨10.3389/fmicb.2022.958307⟩ Article dans une revue (article de synthèse) hal-03738722v1
TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium Isabelle Fleurot,Raquel López-Gálvez,Pascal Barbry,Antoine Guillon,Mustapha Si-Taharet al. Journal of Cystic Fibrosis, 2022, 21 (2), pp.e117-e121. ⟨10.1016/j.jcf.2021.08.002⟩ Article dans une revue hal-03556846v1
Airway administration of flagellin regulates the inflammatory response to Pseudomonas aeruginosa Raquel López-Gálvez,Isabelle Fleurot,Pablo Chamero,Sascha Trapp,Olivier Michelet al. American Journal of Respiratory Cell and Molecular Biology, 2021, 65 (4), pp.378-389. ⟨10.1165/rcmb.2021-0125OC⟩ Article dans une revue hal-03258174v1
Evidence of early increased sialylation of airway mucins and defective mucociliary clearance in CFTR-deficient piglets Ignacio Caballero,Bélinda Ringot-Destrez,Mustapha Si-Tahar,Pascal Barbry,Antoine Guillonet al. Journal of Cystic Fibrosis, 2021, 20 (1), pp.173-182. ⟨10.1016/j.jcf.2020.09.009⟩ Article dans une revue hal-02967168v1
Where Is the Cystic Fibrosis Transmembrane Conductance Regulator? Pascal Barbry,Brice Marcet,Ignacio Caballero American Journal of Respiratory and Critical Care Medicine, 2021, 203 (10), pp.1214 - 1216. ⟨10.1164/rccm.202012-4434ED⟩ Article dans une revue hal-03264909v1
Intrinsic alterations in peripheral neutrophils from cystic fibrosis newborn piglets Deborah Brea,Laura Soler,Isabelle Fleurot,Sandrine Melo,Claire Chevaleyreet al. Journal of Cystic Fibrosis, 2020, 19 (5), pp.830-836. ⟨10.1016/j.jcf.2020.02.016⟩ Article dans une revue hal-03012482v1
CFTR-deficient pigs display alterations of bone microarchitecture and composition at birth Julien Braux,Marie-Laure Jourdain,Christine Guillaume,Valérie Untereiner,Olivier Piotet al. Journal of Cystic Fibrosis, 2020, 19 (3), pp.466-475. ⟨10.1016/j.jcf.2019.10.023⟩ Article dans une revue hal-02406264v1
Tetrafunctional Block Copolymers Promote Lung Gene Transfer in Newborn Piglets Ignacio Caballero,Mickaël Riou,Océane Hacquin,Claire Chevaleyre,Céline Barcet al. Molecular Therapy - Nucleic Acids, 2019, 16, pp.186-193. ⟨10.1016/j.omtn.2019.02.016⟩ Article dans une revue inserm-02080870v1
Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures Sandra Ruiz Garcia,Marie Deprez,Kevin Lebrigand,Amelie Cavard,Agnès Paquetet al. Development (Cambridge, England), 2019, 146 (20), 17p. ⟨10.1242/dev.177428⟩ Article dans une revue hal-02628140v1
Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol Ignacio Caballero-Posadas,James Boyd,Carmen Alminana-Brines,Javier A. Sánchez-López,Shaghayegh Basatvatet al. Scientific Reports, 2017, 7, 10 p. ⟨10.1038/srep40981⟩ Article dans une revue hal-01594679v1
Generation of a Stable Transgenic Swine Model Expressing a Porcine Histone 2B-eGFP Fusion Protein for Cell Tracking and Chromosome Dynamics Studies Renan B. Sper,Sehwon Koh,Xia Zhang,Sean Simpson,Bruce Collinset al. PLoS ONE, 2017, 12 (1), 24 p. ⟨10.1371/journal.pone.0169242⟩ Article dans une revue hal-01607549v1
Interleukin-1 receptor antagonist mediates toll-like receptor 3-induced inhibition of trophoblast adhesion to endometrial cells in vitro M. Montazeri,J.A. Sanchez-Lopez,Ignacio Caballero,N. Maslehat Lay,S. Elliottet al. Human Reproduction, 2016, 31 (9), pp.2098-2107. ⟨10.1093/humrep/dew171⟩ Article dans une revue hal-02634561v1
The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection. Claire Chevaleyre,Mickaël Riou,Deborah Brea,Clarisse Vandebrouck,Céline Barcet al. PLoS ONE, 2016, 11 (12), pp.e0168577. ⟨10.1371/journal.pone.0168577⟩ Article dans une revue hal-01437131v1
Computed tomography (CT) scanning facilitates early identification of neonatal cystic fibrosis piglets Antoine Guillon,Claire Chevaleyre,Céline Barc,Mustapha Berri,Hans Adriaensenet al. PLoS ONE, 2015, 10 (11), pp.1-12. ⟨10.1371/journal.pone.0143459⟩ Article dans une revue hal-01594228v1
Activation of Toll-like receptor 3 reduces actin polymerization and adhesion molecule expression in endometrial cells, a potential mechanism for viral-induced implantation failure M. Montazeri,J.A. Sanchez-Lopez,Ignacio Caballero-Posadas,N. Maslehat Lay,S. Elliottet al. Human Reproduction, 2015, 30 (4), pp.893-905. ⟨10.1093/humrep/deu359⟩ Article dans une revue hal-01171121v1
The battle of the sexes starts in the oviduct: modulation of oviductal transcriptome by X and Y-bearing spermatozoa Carmen Alminana,Ignacio Caballero,Paul Roy Heath,Saeedeh Maleki-Dizaji,Inmaculada Parrillaet al. BMC Genomics, 2014, 15, pp.1-11. ⟨10.1186/1471-2164-15-293⟩ Article dans une revue hal-02635235v1
Local Activation of Uterine Toll-Like Receptor 2 and 2/6 Decreases Embryo Implantation and Affects Uterine Receptivity in Mice Javier Arturo Sanchez-Lopez,Ignacio Caballero,Mehrnaz Montazeri,Nasim Maslehat,Sarah Elliottet al. Biology of Reproduction, 2014, 90 (4), pp.1-13. ⟨10.1095/biolreprod.113.115253⟩ Article dans une revue hal-02637664v1
Human Trophoblast Cells Modulate Endometrial Cells Nuclear Factor kappa B Response to Flagellin In Vitro Ignacio Caballero,Sumiah Al Ghareeb,Shaghayegh Basatvat,Javier A. Sánchez-López,Mehrnaz Montazeriet al. PLoS ONE, 2013, 8 (1), pp.1-10. ⟨10.1371/journal.pone.0039441⟩ Article dans une revue hal-02646437v1
The Effect of Glycerol Concentrations on the Post-thaw In Vitro Characteristics of Cryopreserved Sex-sorted Boar Spermatozoa I. Parrilla,D. del Olmo,Ignacio Caballero,T. Tarantini,C. Cuelloet al. Reproduction in Domestic Animals, 2012, 47 (6), pp.965 - 974. ⟨10.1111/j.1439-0531.2012.02000.x⟩ Article dans une revue istex hal-02647199v1
Seminal Plasma Proteins as Modulators of the Sperm Function and Their Application in Sperm Biotechnologies Ignacio Caballero,I. Parrilla,Carmen Alminana,D. del Olmo,J. Rocaet al. Reproduction in Domestic Animals, 2012, 47 (Suppl.3), pp.12-21. ⟨10.1111/j.1439-0531.2012.02028.x⟩ Article dans une revue (article de synthèse) istex hal-02649909v1
Influence of storage time on functional capacity of flow cytometrically sex-sorted boar spermatozoa Ignacio Caballero-Posadas,Inmaculada Parrilla,Juan Vazquez,Maria Gil,Ignacio Caballeroet al. Theriogenology, 2005, 64 (1), pp.86-98. ⟨10.1016/j.theriogenology.2004.11.004⟩ Article dans une revue istex hal-03449663v1
Comparative Effects of Autologous and Homologous Seminal Plasma on the Viability of Largely Extended Boar Spermatozoa Ignacio Caballero-Posadas,Jm Vazquez,F Centurión,H Rodríguez-Martinez,I Parrillaet al. Reproduction in Domestic Animals, 2004, 39 (5), pp.370-375. ⟨10.1111/j.1439-0531.2004.00530.x⟩ Article dans une revue istex hal-03449115v1

Communication dans un congrès (10)

A new immunosuppressed pig model to study chronic Hepatitis E infection and the genetic viral diversity Nancy León Janampa,Ignacio Caballero-Posadas,Céline Barc,François Darrouzain,Philippe Gataultet al. 17. Congrès national de la SFM - Microbes 2022, Société Française de Microbiologie, Oct 2022, Montpellier, France Communication dans un congrès hal-03908226v1
A new immunosuppressed pig model to study chronic Hepatitis E infection and its impact on host innate immune responses Julien Marlet,Nancy León Janampa,Ignacio Caballero-Posadas,Céline Barc,François Darrouzainet al. Journées d'Animation Scientifique de la FéRI 2022 - FéRi Scientific Days 2022, Fédération de Recherche en Infectiologie (FéRI), Centre Val de Loire, Jul 2022, Joué-Lès-Tours, France Communication dans un congrès hal-03735443v1
Faecal gut microbiota composition determines susceptibility to Salmonella Enteritidis primo-colonization Florent Kempf,Pierrette Menanteau,Ivan Rychlik,Rosanna Drumo,Ignacio Caballeroet al. OneHealth EJP Annual Scientific meeting 2020 - Online, May 2020, Pragues - Online, Czech Republic Communication dans un congrès hal-03186758v1
Novel approaches boosting innate immunity against &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; Isabelle Fleurot,Mickael Riou,Claire Chevaleyre,Sandrine Melo,Michel Olivieret al. 15. Congrès National de la Société Française de Microbiologie (SFM), Société Française de Microbiologie (SFM). FRA., Sep 2019, Paris, France. pp.436 Communication dans un congrès hal-02736599v1
The cystic fibrosis pig model : advantages and disadvantages Ignacio Caballero-Posadas Journée thématique Biotechnocentre « Modèles animaux et leurs alternatives: quel avenir ? », Jun 2016, Joué-les-Tours, France Communication dans un congrès hal-02792567v1
Closing remarks Ignacio Caballero International Conference on Cystic fibrosis: contribution of animal models to therapeutic development, Nov 2015, Tours, France Communication dans un congrès hal-02792244v1
The European CF pig model: ups, downs and perspectives Ignacio Caballero International Conference on Cystic fibrosis: contribution of animal models to therapeutic development, Nov 2015, Tours, France Communication dans un congrès hal-02792552v1
Neutrophils in cystic fibrosis. Are they intrinsically defective? Deborah Brea,Laura Soler Vasco,Antoine Guillon,Claire C. Chevaleyre,Celine Barcet al. Journées d'Animation Scientifique de la Fédération de Recherche d'Infectiologie (FéRI), Oct 2015, Orléans, France. 2 p Communication dans un congrès hal-02799967v1
Contribution of computed tomography (CT) scan to extend the lifespan of a porcine CFTR - / - model Ignacio Caballero,Antoine Guillon,Celine Barc,El Mostafa Berri,Claire C. Chevaleyreet al. 8. European CF Young Investigator Meeting, Feb 2014, Paris, France. 19 Diapositives Communication dans un congrès hal-02793962v1
Développement d'un modèle d'infection respiratoire aiguë à Pseudomonas aeruginosa chez le porc Mickaël Riou,Claire C. Chevaleyre,Deborah Brea,Celine Barc,Clarisse Vandebroucket al. 34. Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI), Nov 2014, Paris, France Communication dans un congrès hal-02799765v1

Poster de conférence (15)

Flagellin treatment: an immunomodulation strategy for controllong swine influenza infection Elaa Chkhaydem,Isabelle Fleurot,Vanaïque Guillory,Emmanuel Kut,Céline Barcet al. 9. International Influenza Meeting:" From bench to bedside", Sep 2024, Münster (DE), Germany. Poster de conférence hal-04913467v1
Dynamique d'expression du virus de la peste porcine africaine et impact sur les voies de l'immunité innée et la virulence Aurélien Leroy,Chloé Styranec,Vanaïque Guillory,Isabelle Fleurot,Marie-Frédérique Le Potieret al. XXVèmes Journées Francophones de Virologie, Apr 2023, Paris, France. Virologie, 27 (2), pp.77-78, 2023 Poster de conférence anses-04471667v1
Modeling Hepatitis E infection in immunocompromised patients using a new pig model Nancy León Janampa,Céline Barc,François Darrouzain,Philippe Gatault,Mickaël Riouet al. 17. International Symposium on Viral Hepatitis and Liver Diseases (ISVHLD), Jun 2021, Taipei, Taiwan. 345 Poster de conférence hal-03388900v1
CFTR-KO pigs exhibit altered bone microarchitecture at birth F. Velard,Marie Laure Jourdain,Ignacio Caballero-Posadas,Nathalie Winter,Mustapha Si-Taharet al. 32. Annual North American Cystic Fibrosis Conference, Oct 2018, Denver, United States. WILEY, Pediatric Pulmonology, 53 (S2), 2018 Poster de conférence hal-02734331v1
CFTR-Deficient Pigs Have Altered Bone Microarchitecture and Elevated Closed Cortical Porosity at Birth Frédéric Velard,Marie Laure Jourdain,Ignacio Caballero-Posadas,Nathalie Winter,Mustapha Si-Taharet al. International Conference of the American-Thoracic-Society (ATS 2018), May 2018, San Diego, United States. AMER THORACIC SOC, American Journal of Respiratory and Critical Care Medicine, 197, 2018 Poster de conférence hal-02734272v1
Flagellin pre-stimulation modulates the immune response to pathogens in pig airway epithelial cells Isabelle Fleurot,Sandrine Melo,Michel Olivier,Claire Chevaleyre,Christophe Carnoyet al. 11. Symposium of the French Domestic Animal Immunology Network (IAD 2018), Mar 2018, Tours, France. , 56 p., 2018 Poster de conférence hal-02736823v1
Toll-like Receptor 9 Activation in Trophoblast-Endometrium Cross-talk N. Maslehat Lay,J. Sanchez-Lopez,Mehrnaz Montazeri,Ignacio Caballero,S. Elliottet al. 49. Annual meeting of the Society for the Study of Reproduction SSR 2016, Jul 2016, San Diego, United States. , 2016 Poster de conférence hal-02799318v1
Le modèle européen de porc CF : un modèle unique pour décrypter les altérations de glycosylation des mucines pulmonaires B. Ringot-Destrez,Ignacio Caballero,Mustapha Si-Tahar,P. Barbry,A. Guillonet al. 17. Colloque des jeunes chercheurs Vaincre la Mucoviscidose, Feb 2016, Paris, France. , 2016 Poster de conférence hal-02800304v1
The pig as a model to determine the origins of cystic fibrosis lung disease Ignacio Caballero,Antoine Guillon,Celine Barc,Isabelle Lantier,Mustapha M. Berriet al. COST Action BM1308 “Sharing Advances in Large Animal Models” (SALAAM), Dec 2015, Poznan, Poland. , 2015 Poster de conférence hal-02800785v1
Development of a functional in vitro cell system to test the role of Tribbles-2 in embryo implantation Shaghayegh Basatvat,Ignacio Caballero,Mehrnaz Montazeri,Javier Arturo Sanchez-Lopez,N. Maslehat Layet al. Tribbles Pseudokinases on the Crossroads of Metabolism, Cancer, Immunity and Development, Apr 2014, Budapest, Hungary. , 2015 Poster de conférence hal-02793491v1
The pig as a model for the study of the early immune response to &lt;em&gt;Pseudomonas Aeruginosa&lt;/em&gt; Mustapha M. Berri,Mickaël Riou,Celine Barc,Deborah Brea,Claire C. Chevaleyreet al. Swine in Biomedical Research Conference, Jul 2014, Raleigh, United States. 2014 Poster de conférence hal-02795088v1
Contribution of computed tomography (CT) scan to extend the lifespan of a porcine CFTR - / - model Ignacio Caballero,Antoine Guillon,Celine Barc,El Mostafa Berri,Claire C. Chevaleyreet al. 8. European CF Young Investigator Meeting, Feb 2014, Paris, France. 2014 Poster de conférence hal-02798139v1
Développement d'un modèle d'infection respiratoire aiguë à Pseudomonas aeruginosa chez le porc Mickaël Riou,Claire C. Chevaleyre,Deborah Brea,Celine Barc,Clarisse Vandebroucket al. 3. Journées d'Animation Scientifique, Jun 2014, Parcay Meslay, France. 2014 Poster de conférence hal-02801096v1
Adjustments of glycerol concentration for improving the post-thaw quality of sex sorted boar spermatozoa I. Parrilla,D. del Olmo,Ignacio Caballero,T. Tarantini,C. Cuelloet al. 11. International Congress of the Spanish Association for Animal Reproduction (AERA), Jun 2012, Cordoba, Spain. , Reproduction in Domestic Animals, 47 (suppl.3), 2012 Poster de conférence hal-02745246v1
Post-thaw quality of boar semen frozen at low sperm concentration I. Parrilla,D. del Olmo,Ignacio Caballero,T. Tarantini,M. A. Gilet al. 15. Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR), Sep 2011, Antalya, Turkey. , Reproduction in Domestic Animals, 46 (suppl.3), 2011, ⟨10.1111/j.1439-0531.2011.01839.x⟩ Poster de conférence hal-02745244v1

Pré-publication, Document de travail (1)

Flagellin aerosol administration improves the efficacy of antibiotic treatment in Actinobacillus pleuropneumoniae infected pigs Isabelle Fleurot,Vanaique Guillory,Céline Barc,Mickael Riou,Alain Desliset al. 2025 Pré-publication, Document de travail hal-05306629v1

HDR (1)

Habilitation à diriger des recherches Ignacio Caballero Ignacio Caballero-Posadas Veterinary medicine and animal Health. Université François Rabelais - Tours, 2020 HDR tel-04181484v1