IF

Isabelle FLORENT

62
Documents

Publications

Publications

Isolation of derivatives from the food-grade probiotic <i>Lactobacillus johnsonii</i> CNCM I-4884 with enhanced anti-Giardia activity

Anne-Sophie Boucard , Saulius Kulakauskas , Jana Alazzaz , Soraya Chaouch , Mohamed Mammeri et al.
Gut microbes, 2025, 17 (1), pp.2474149. ⟨10.1080/19490976.2025.2474149⟩
Article dans une revue hal-05038698 v1

Porospora gigantea

Julie Boisard , Isabelle Florent
Trends in Parasitology, 2023, 39 (10), pp.886-887. ⟨10.1016/j.pt.2023.05.013⟩
Article dans une revue hal-04455548 v1
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Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families

Isel Pascual , Fabiola Almeida García , Mario Ernesto Valdés Tresano , Yarini Arrebola Sánchez , Daniel Ojeda del Sol et al.
Marine drugs, 2023, 21 (5), pp.279. ⟨10.3390/md21050279⟩
Article dans une revue (article de synthèse) hal-04085369 v1
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Parasitic Protists: Diversity of Adaptations to a Parasitic Lifestyle

Iva Kolářová , Isabelle Florent , Andrea Valigurová
Microorganisms, 2022, Parasitic Protists: Diversity of Adaptations to a Parasitic Lifestyle, 10 (8), pp.1560. ⟨10.3390/microorganisms10081560⟩
Article dans une revue hal-03880807 v1
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Marine gregarine genomes reveal the breadth of apicomplexan diversity with a partially conserved glideosome machinery

Julie Boisard , Evelyne Duvernois-Berthet , Linda Duval , Joseph Schrével , Laure Guillou et al.
BMC Genomics, 2022, 23 (1), pp.485. ⟨10.1186/s12864-022-08700-8⟩
Article dans une revue hal-03862695 v1
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Genome Sequence and Assessment of Safety and Potential Probiotic Traits of Lactobacillus johnsonii CNCM I-4884

Anne-Sophie Boucard , Isabelle Florent , Bruno Polack , Philippe Langella , Luis Bermúdez-Humarán
Microorganisms, 2022, 10 (2), pp. 273. ⟨10.3390/microorganisms10020273⟩
Article dans une revue hal-03880814 v1

Age and Giardia intestinalis Infection Impact Canine Gut Microbiota

Anne-Sophie Boucard , Myriam Thomas , Wilfried Lebon , Bruno Polack , Isabelle Florent et al.
Microorganisms, 2021, 9 (9), pp.1862. ⟨10.3390/microorganisms9091862⟩
Article dans une revue hal-03881565 v1
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Nutrient Acquisition and Attachment Strategies in Basal Lineages: A Tough Nut to Crack in the Evolutionary Puzzle of Apicomplexa

Andrea Valigurová , Isabelle Florent
Microorganisms, 2021, 9 (7), pp.1430. ⟨10.3390/microorganisms9071430⟩
Article dans une revue hal-03881552 v1
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Programmed multiple C-H bond functionalization of the privileged 4hydroxyquinoline template

Quentin Ronzon , Wei Zhang , Nicolas Casaretto , Elisabeth Mouray , Isabelle Florent et al.
Chemistry - A European Journal, 2021, 27 (28), pp.7764-7772. ⟨10.1002/chem.202100929⟩
Article dans une revue hal-03256641 v1
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Structure-activity relationship and molecular modelling studies of quinazolinedione derivatives MMV665916 as potential antimalarial agent

Laura Mourot , Marjorie Schmitt , Elisabeth Mouray , Martin Spichty , Isabelle Florent et al.
Bioorganic and Medicinal Chemistry Letters, 2021, 51, pp.116513. ⟨10.1016/j.bmc.2021.116513⟩
Article dans une revue hal-03432154 v1
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Integrative taxonomy confirms that Gregarina garnhami and G. acridiorum (Apicomplexa, Gregarinidae), parasites of Schistocerca gregaria and Locusta migratoria (Insecta, Orthoptera), are distinct species

Isabelle Florent , Marie Pierre Chapuis , Amandine Labat , Julie Boisard , Nicolas Leménager et al.
Parasite, 2021, 28, pp.12. ⟨10.1051/parasite/2021009⟩
Article dans une revue hal-03150621 v1
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Rapid protein evolution, organellar reductions, and invasive intronic elements in the marine aerobic parasite dinoflagellate Amoebophrya spp

Sarah Farhat , Phuong Le , Ehsan Kayal , Benjamin Noel , Estelle Bigeard et al.
BMC Biology, 2021, 19 (1), ⟨10.1186/s12915-020-00927-9⟩
Article dans une revue hal-03114990 v1

IgG antibody response against Plasmodium falciparum aminopeptidase 1 antigen in Gabonese children living in Makokou and Franceville

S. Oyegue‐liabagui , R.‐k. Imboumy‐limoukou , C. Kouna , F. Bangueboussa , Marjorie Schmitt et al.
Clinical and Experimental Immunology, 2020, 200 (3), pp.287-298. ⟨10.1111/cei.13425⟩
Article dans une revue hal-02498387 v1
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Why the –omic future of Apicomplexa should include Gregarines

Julie Boisard , Isabelle Florent
Biology of the Cell, 2020, ⟨10.1111/boc.202000006⟩
Article dans une revue hal-02553206 v1
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Marine organisms : a source of biomedically relevant metallo M1, M2 and M17 exopeptidase inhibitors

Isel Pascual Alonso , Laura Rivera Méndez , Fabiola Almeida , Mario Ernesto Valdés Tresano , Yarini Arrebola Sánchez et al.
REVISTA CUBANA DE CIENCIAS BIOLÓGICAS, 2020, 8 (2), pp.1-36
Article dans une revue hal-02944434 v1
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Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation

Emmanuel Salomon , Marjorie Schmitt , Elisabeth Mouray , Alastair G Mcewen , Lotfi Bounaadja et al.
Bioorganic Chemistry, 2020, 98, pp.103750. ⟨10.1016/j.bioorg.2020.103750⟩
Article dans une revue hal-02530528 v1
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Biochemical evidences for M1-, M17- and M18-like aminopeptidases in marine invertebrates from Cuban coastline

Isel Pascual Alonso , Laura Rivera Méndez , Mario E Valdés-Tresanco , Lotfi Bounaadja , Marjorie Schmitt et al.
Zeitschrift fur Naturforschung C, 2020, ⟨10.1515/znc-2019-0169⟩
Article dans une revue hal-02902526 v1
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Metallopeptidases of Toxoplasma gondii : in silico identification and gene expression

Sandie Escotte-Binet , Antoine Huguenin , Dominique Aubert , Anne-Pascaline Martin , Matthieu Kaltenbach et al.
Parasite, 2018, 25, pp.26. ⟨10.1051/parasite/2018025⟩
Article dans une revue hal-03110320 v1
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Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases

Emmanuel Salomon , Marjorie Schmitt , Anil Kumar Marapaka , Athanasios Stamogiannos , Germain Revelant et al.
Molecules, 2018, 23 (10), pp.2607. ⟨10.3390/molecules23102607⟩
Article dans une revue hal-02128705 v1
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Bile Salt Hydrolase Activities: A Novel Target to Screen Anti-Giardia Lactobacilli?

Thibault Allain , Soraya Chaouch , Myriam Thomas , Marie-Agnès Travers , Isabelle Vallée et al.
Frontiers in Microbiology, 2018, 9, ⟨10.3389/fmicb.2018.00089⟩
Article dans une revue hal-02126886 v1
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Bile-Salt-Hydrolases from the Probiotic Strain Lactobacillus johnsonii La1 Mediate Anti-giardial Activity in Vitro and in Vivo

Thibault Allain , Soraya Chaouch , Myriam Thomas , Isabelle Vallée , André Buret et al.
Frontiers in Microbiology, 2018, 8, pp.1-15. ⟨10.3389/fmicb.2017.02707⟩
Article dans une revue hal-02126890 v1
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Comparative Time-Scale Gene Expression Analysis Highlights the Infection Processes of Two Amoebophrya Strains

Sarah Farhat , Isabelle Florent , Benjamin Noël , Ehsan Kayal , Corinne da Silva et al.
Frontiers in Microbiology, 2018, 9, ⟨10.3389/fmicb.2018.02251⟩
Article dans une revue hal-02126891 v1
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Aqueous extracts of marine invertebrates from Cuba coastline display neutral aminopeptidase inhibitory activities and effects on cancer cells and Plasmodium falciparum parasites

Isel Pascual Alonso , L Bounaadja , L Sánchez , L Rivera , Celine Tarnus et al.
Indian Journal of Natural Products and Resources, 2017, 8 (2), pp.107-119
Article dans une revue hal-02154722 v1

Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN)

Isel Pascual , Pedro Valiente , Gabriela Garcia , Mario Valdés-Tresanco , Yarini Arrebola et al.
Biochimie, 2017, 142 (5), pp.216-225. ⟨10.1016/j.biochi.2017.09.015⟩
Article dans une revue hal-02126895 v1
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Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo

Lotfi Bounaadja , Marjorie Schmitt , Sébastien Albrecht , Elisabeth Mouray , Céline Tarnus et al.
Malaria Journal, 2017, 16 (1), pp.382. ⟨10.1186/s12936-017-2032-4⟩
Article dans une revue hal-02126893 v1

KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library

Jorge Gonzales-Bazerio , Sarah El Chamy Maluf , Yanira Méndez , Isel Pascual , Isabelle Florent et al.
Bioorganic and Medicinal Chemistry, 2017, 25 (17), pp.4628-4636. ⟨10.1016/j.bmc.2017.06.047⟩
Article dans une revue hal-02134397 v1
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Ultrastructure of Selenidium pendula, the Type Species of Archigregarines, and Phylogenetic Relations to Other Marine Apicomplexa

Joseph Schrével , Andrea Valigurová , Gérard Prensier , Aurélie Chambouvet , Isabelle Florent et al.
Protist, 2016, 167 (4), pp.339-368. ⟨10.1016/j.protis.2016.06.001⟩
Article dans une revue hal-01338422 v1
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Comparative antibody responses against three antimalarial vaccine candidate antigens from urban and rural exposed individuals in Gabon

Roméo-Karl Imboumy-Limoukou , Sandrine Lydie Oyegue-Liabagui , Stella Ndidi , Irène Pegha-Moukandja , Charlene Lady Kouna et al.
European Journal of Microbiology and Immunology, 2016, 6 (4), pp.287-297. ⟨10.1556/1886.2016.00027⟩
Article dans une revue hal-02134412 v1

Immunoglobulin response to the low polymorphic Pf113 antigen in children from Lastoursville, South-East of Gabon

Roméo Karl Imboumy-Limoukou , Sidney Maghendi-Nzondo , Charlene Lady Kouna , Lotfi Bounaadja , Sophie Mbang et al.
Acta Tropica, 2016, 163, pp.149-156. ⟨10.1016/j.actatropica.2016.08.014⟩
Article dans une revue hal-01998452 v1
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Wesley van Voorhis , John Adams , Roberto Adelfio , Vida Ahyong , Myles Akabas et al.
PLoS Pathogens, 2016, 12 (7), pp.e1005763. ⟨10.1371/journal.ppat.1005763⟩
Article dans une revue hal-02905407 v1

Redescription of Dicyemennea eledones (Wagener, 1857) (Phylum Dicyemida) from Eledone cirrhosa (Lamarck, 1798) (Mollusca: Cephalopoda: Octopoda)

Dhikra Souidenne , Isabelle Florent , Marc Dellinger , Mohamed Salah Romdhane , Philippe Grellier et al.
Systematic Parasitology, 2016, 93 (9), pp.905-915. ⟨10.1007/s11230-016-9659-3⟩
Article dans une revue hal-02134414 v1
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Deconjugated bile salts produced by extracellular bile-salt hydrolase-like activities from the probiotic <em>Lactobacillus johnsonii</em> La1 inhibit Giardia duodenalis in vitro growth

Marie-Agnès Travers , Cissé Sow , Séverine Zirah , Christiane Deregnaucourt , Soraya Chaouch et al.
Frontiers in Microbiology, 2016, 7, pp.1-16. ⟨10.3389/fmicb.2016.01453⟩
Article dans une revue hal-02637819 v1

A new lactobacilli in vivo expression system for the production and delivery of heterologous proteins at mucosal surfaces

Thibault Allain , Nahla M Mansour , May M. A. Bahr , Rebeca Martín , Isabelle Florent et al.
FEMS Microbiology Letters, 2016, 363 (13), ⟨10.1093/femsle/fnw117⟩
Article dans une revue hal-02634544 v1
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Diversity of apostome ciliates, Chromidina spp. (Oligohymenophorea, Opalinopsidae), parasites of cephalopods of the Mediterranean Sea

Dhikra Souidenne , Isabelle Florent , Marc Dellinger , Jean Lou Justine , Mohamed Salah Romdhane et al.
Parasite, 2016, 23, pp.33. ⟨10.1051/parasite/2016033⟩
Article dans une revue hal-01368204 v1

Access to New Endoperoxide Derivatives by Electrochemical Oxidation of Substituted 3-Azabicyclo[4.1.0]hept-4-enes

Frédérick Nuter , Abdou Khadre Djily Dimé , Cheng Chen , Lotfi Bounaadja , Elisabeth Mouray et al.
Chemistry - A European Journal, 2015, 21 (14), pp.5584-5593. ⟨10.1002/chem.201406138⟩
Article dans une revue istex hal-01178411 v1
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Genetic impairment of parasite myosin motors uncovers the contribution of host cell membrane dynamics to Toxoplasma invasion forces

Marion Bichet , Bastien Touquet , Virginie Gonzalez , Isabelle Florent , Markus Meissner et al.
BMC Biology, 2015, 14 (1), pp.97. ⟨10.1186/s12915-016-0316-8⟩
Article dans une revue inserm-01394800 v1
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Identification of divergent protein domains by combining HMM-HMM comparisons and co-occurrence detection

Amel Ghouila , Isabelle Florent , Fatma Zahra Guerfali , Nicolas Terrapon , Dhafer Laouini et al.
PLoS ONE, 2014, 9 (6), pp.e95275. ⟨10.1371/journal.pone.0095275⟩
Article dans une revue pasteur-01060276 v1

Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L.

Jane Namukobe , Bernard T Kiremire , Robert Byamukama , John M Kasenene , Vincent Dumontet et al.
Phytochemistry, 2014, 102, pp.189-196. ⟨10.1016/j.phytochem.2014.02.005⟩
Article dans une revue hal-01005175 v1
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Diversity and biological activities of the bacterial community associated with the marine sponge Phorbas tenacior (Porifera, Demospongiae).

S Dupont , Alyssa Carré-Mlouka , F Descarrega , Alexander Ereskovsky , A Longeon et al.
Letters in Applied Microbiology, 2013, 58 (1), pp.42-52. ⟨10.1111/lam.12154⟩
Article dans une revue hal-01456679 v1

Antimalarial screening via large-scale purification of Plasmodium falciparum Ca 2+ -ATPase 6 and in vitro studies

Stéphanie David-Bosne , Isabelle Florent , Anne-Marie Lund- Winther , John H. L. Hansen , Morten Buch-Pedersen et al.
FEBS Journal, 2013, 280 (21), pp.5419-5429. ⟨10.1111/febs.12244⟩
Article dans une revue mnhn-02904306 v1
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Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors

Rébecca F. Déprez-Poulain , Marion Flipo , Catherine Piveteau , Florence Leroux , Sandrine Dassonneville et al.
Journal of Medicinal Chemistry, 2012, 55 (24), pp.10909-10917. ⟨10.1021/jm301506h⟩
Article dans une revue hal-03051765 v1
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Probiotics for the Control of Parasites: An Overview

Marie-Agnès Travers , Isabelle Florent , Linda Kohl , Philippe Grellier
Journal of Parasitology Research, 2011, 2011, pp.1-11. ⟨10.1155/2011/610769⟩
Article dans une revue mnhn-02047396 v1
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Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole

Omid Azimzadeh , Cissé Sow , Marc Gèze , Julius Nyalwidhe , Isabelle Florent
Malaria Journal, 2010, 9 (1), pp.189. ⟨10.1186/1475-2875-9-189⟩
Article dans une revue mnhn-02904304 v1

Aminocyclopropanes as precursors of endoperoxides with antimalarial activity

Claire Madelaine , Olivier Buriez , Benoit Crousse , Isabelle Florent , Philippe Grellier et al.
Organic & Biomolecular Chemistry, 2010, 8 (24), pp.5591. ⟨10.1039/c0ob00308e⟩
Article dans une revue istex mnhn-02047403 v1
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Bioinformatic strategies to provide functional clues to the unknown genes in Plasmodium falciparum genome

Isabelle Florent , Eric Maréchal , Olivier Gascuel , Laurent Brehelin
Parasite, 2010, 17 (4), pp.273-283. ⟨10.1051/parasite/2010174273⟩
Article dans une revue hal-02659756 v1
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Assessing Functional Annotation Transfers with Inter-Species Conserved Coexpression: Application to Plasmodium Falciparum

Laurent Brehelin , Isabelle Florent , Olivier Gascuel , Eric Maréchal
BMC Genomics, 2010, 11 (35), pp.1471-2164. ⟨10.1186/1471-2164-11-35⟩
Article dans une revue lirmm-00540866 v1
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A Plasmodium Falciparum FcB1-Schizont-EST Collection Providing Clues to Schizont Specific Gene Structure and Polymorphism

Isabelle Florent , Betina M Porcel , Elodie Guillaume , Corinne da Silva , François Artiguenave et al.
BMC Genomics, 2009, 10, pp.235-252. ⟨10.1186/1471-2164-10-235⟩
Article dans une revue lirmm-00395282 v1
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Discovery of new targets for antimalarial chemotherapy

Philippe Grellier , Delphine Depoix , Joseph Schrével , I Florent
Parasite, 2008, 15 (3), pp.219-225. ⟨10.1051/parasite/2008153219⟩
Article dans une revue mnhn-02070082 v1

Characterization of PfDYN2, a dynamin-like protein of Plasmodium falciparum expressed in schizonts

Sébastien Charneau , Izabela Bastos , Barbara Gomes Ribeiro , J.M. Santana , Philippe Grellier et al.
Microbes and Infection, 2007, 9 (7), pp.797-805. ⟨10.1016/j.micinf.2007.02.020⟩
Article dans une revue istex mnhn-02070094 v1

Novel Selective Inhibitors of the Zinc Plasmodial Aminopeptidase PfA-M1 as Potential Antimalarial Agents

Marion Flipo , Terence Beghyn , Virginie Leroux , Isabelle Florent , Benoit Déprez et al.
Journal of Medicinal Chemistry, 2007, 50 (6), pp.1322-1334. ⟨10.1021/jm061169b⟩
Article dans une revue istex mnhn-02904302 v1

Biochemical properties and cellular localization of Plasmodium falciparum protein disulfide isomerase

Elisabeth Mouray , Mireille Moutiez , S Girault , Christian Sergheraert , I Florent et al.
Biochimie, 2007, 89 (3), pp.337-346. ⟨10.1016/j.biochi.2006.11.001⟩
Article dans une revue istex mnhn-02070098 v1

Labelling of four distinct trophozoite falcipains of Plasmodium falciparum by a cystatin-derived probe

Isabelle Florent , Fabien Lecaille , Jean-Jacques Montagne , Francis Gauthier , Joseph Schrével et al.
Biological Chemistry, 2005, 386 (4), pp.401 - 406. ⟨10.1515/BC.2005.048⟩
Article dans une revue istex mnhn-02904301 v1

Plasmodium falciparum genes differentially expressed during merozoite morphogenesis.

I Florent , Sébastien Charneau , Philippe Grellier
Molecular and Biochemical Parasitology, 2004
Article dans une revue mnhn-02070129 v1
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Design, synthesis and antimalarial activity of novel, quinoline-Based, zinc metallo-aminopeptidase inhibitors

Marian Flipo , Isabelle Florent , Philippe Grellier , Christian Sergheraert , Rebecca Déprez-Poulain
Bioorganic and Medicinal Chemistry Letters, 2003, 13 (16), pp.2659-2662. ⟨10.1016/S0960-894X(03)00550-X⟩
Article dans une revue mnhn-02867485 v1

Plasmodium falciparum proteinases: cloning of the putative gene coding for the merozoite proteinase for erythrocyte invasion (MPEI) and determination of hydrolysis sites of spectrin by Pf37 proteinase

Isabelle Florent , S. Le Bonniec , B. Carcy , P. Grellier , O. Mercereau-Puijalon et al.
Memórias do Instituto Oswaldo Cruz, 1994, 89 (suppl 2), pp.47-49. ⟨10.1590/s0074-02761994000600012⟩
Article dans une revue hal-03881542 v1

Probiotics against Giardia in a One Health approach

Isabelle Florent , Bruno Polack , Luis Bermúdez-Humarán
Annual meeting of the European Veterinary Parasitology College, EVPC, Jun 2023, Maison Alfort, France
Communication dans un congrès hal-04541093 v1

Probiotics against Giardia, which therapeutic future?

Isabelle Florent , Bruno Polack , Luis Bermúdez-Humarán
12èmes journées du consortium anti-parasitaire et fongique « Zoonoses : évaluation des risques et stratégies thérapeutiques », CaPF, Apr 2023, Tours, France
Communication dans un congrès hal-04541065 v1

Giardia intestinalis, de l'homme à l'animal et vice & versa

Bruno Polack , Myriam Thomas , Isabelle Florent , Luis Bermúdez-Humarán
congrès annuel conjoint des Sociétés Françaises de Mycologie Médicale et de Parasitologie, Oct 2021, Lyon, France
Communication dans un congrès hal-04541459 v1

Rôle des Bile Salt Hydrolases dans le contrôle de la Giardiose par des lactobacilles, in vitro et in vivo

Thibault Allain , Soraya Chaouch , Myriam Thomas , Isabelle Vallée , André G Buret et al.
8èmes journées du consortium anti-parasitaire et fongique, CaPF, Mar 2018, Lyon, France
Communication dans un congrès hal-04541164 v1

Probiotics against Giardia: a future therapeutic alternative?

Anne-Sophie Boucard , Philippe Langella , Bruno Polack , Isabelle Florent , Luis Bermúdez-Humaran
Lactic Acid Bacteria Biology, Symbioses and Applications Gordon Research Conference, Jul 2023, Ventura (CA), United States
Poster de conférence hal-04541448 v1