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Isabelle FLORENT

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Publications

Porospora gigantea

Julie Boisard , Isabelle Florent
Trends in Parasitology, 2023, 39 (10), pp.886-887. ⟨10.1016/j.pt.2023.05.013⟩
Journal articles hal-04455548v1
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Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families

Isel Pascual , Fabiola Almeida García , Mario Ernesto Valdés Tresano , Yarini Arrebola Sánchez , Daniel Ojeda del Sol
Marine drugs, 2023, 21 (5), pp.279. ⟨10.3390/md21050279⟩
Journal articles hal-04085369v1

Parasitic Protists: Diversity of Adaptations to a Parasitic Lifestyle

Iva Kolářová , Isabelle Florent , Andrea Valigurová
Microorganisms, 2022, 10 (8), pp.1560. ⟨10.3390/microorganisms10081560⟩
Journal articles hal-03880807v1

Genome Sequence and Assessment of Safety and Potential Probiotic Traits of Lactobacillus johnsonii CNCM I-4884

Anne-Sophie Boucard , Isabelle Florent , Bruno Polack , Philippe Langella , Luis Bermúdez-Humarán
Microorganisms, 2022, 10 (2), pp. 273. ⟨10.3390/microorganisms10020273⟩
Journal articles hal-03880814v1
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Marine gregarine genomes reveal the breadth of apicomplexan diversity with a partially conserved glideosome machinery

Julie Boisard , Evelyne Duvernois-Berthet , Linda Duval , Joseph Schrével , Laure Guillou
BMC Genomics, 2022, 23 (1), pp.485. ⟨10.1186/s12864-022-08700-8⟩
Journal articles hal-03862695v1
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Structure-activity relationship and molecular modelling studies of quinazolinedione derivatives MMV665916 as potential antimalarial agent

Laura Mourot , Marjorie Schmitt , Elisabeth Mouray , Martin Spichty , Isabelle Florent
Bioorganic and Medicinal Chemistry Letters, 2021, 51, pp.116513. ⟨10.1016/j.bmc.2021.116513⟩
Journal articles hal-03432154v1

Nutrient Acquisition and Attachment Strategies in Basal Lineages: A Tough Nut to Crack in the Evolutionary Puzzle of Apicomplexa

Andrea Valigurová , Isabelle Florent
Microorganisms, 2021, 9 (7), pp.1430. ⟨10.3390/microorganisms9071430⟩
Journal articles hal-03881552v1

Age and Giardia intestinalis Infection Impact Canine Gut Microbiota

Anne-Sophie Boucard , Myriam Thomas , Wilfried Lebon , Bruno Polack , Isabelle Florent
Microorganisms, 2021, 9 (9), pp.1862. ⟨10.3390/microorganisms9091862⟩
Journal articles hal-03881565v1
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Programmed multiple C-H bond functionalization of the privileged 4hydroxyquinoline template

Quentin Ronzon , Wei Zhang , Nicolas Casaretto , Elisabeth Mouray , Isabelle Florent
Chemistry - A European Journal, 2021, 27 (28), pp.7764-7772. ⟨10.1002/chem.202100929⟩
Journal articles hal-03256641v1
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Integrative taxonomy confirms that Gregarina garnhami and G. acridiorum (Apicomplexa, Gregarinidae), parasites of Schistocerca gregaria and Locusta migratoria (Insecta, Orthoptera), are distinct species

Isabelle Florent , Marie Pierre Chapuis , Amandine Labat , Julie Boisard , Nicolas Leménager
Parasite, 2021, 28, pp.12. ⟨10.1051/parasite/2021009⟩
Journal articles hal-03150621v1
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Rapid protein evolution, organellar reductions, and invasive intronic elements in the marine aerobic parasite dinoflagellate Amoebophrya spp

Sarah Farhat , Phuong Le , Ehsan Kayal , Benjamin Noel , Estelle Bigeard
BMC Biology, 2021, 19 (1), ⟨10.1186/s12915-020-00927-9⟩
Journal articles hal-03114990v1
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Why the –omic future of Apicomplexa should include Gregarines

Julie Boisard , Isabelle Florent
Biology of the Cell, 2020, ⟨10.1111/boc.202000006⟩
Journal articles hal-02553206v1

IgG antibody response against Plasmodium falciparum aminopeptidase 1 antigen in Gabonese children living in Makokou and Franceville

S. Oyegue‐liabagui , R.‐k. Imboumy‐limoukou , C. Kouna , F. Bangueboussa , Marjorie Schmitt
Clinical and Experimental Immunology, 2020, 200 (3), pp.287-298. ⟨10.1111/cei.13425⟩
Journal articles hal-02498387v1
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Biochemical evidences for M1-, M17- and M18-like aminopeptidases in marine invertebrates from Cuban coastline

Isel Pascual Alonso , Laura Rivera Méndez , Mario E Valdés-Tresanco , Lotfi Bounaadja , Marjorie Schmitt
Zeitschrift fur Naturforschung C, 2020, ⟨10.1515/znc-2019-0169⟩
Journal articles hal-02902526v1
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Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluation

Emmanuel Salomon , Marjorie Schmitt , Elisabeth Mouray , Alastair G Mcewen , Lotfi Bounaadja
Bioorganic Chemistry, 2020, 98, pp.103750. ⟨10.1016/j.bioorg.2020.103750⟩
Journal articles hal-02530528v1
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Marine organisms : a source of biomedically relevant metallo M1, M2 and M17 exopeptidase inhibitors

Isel Pascual Alonso , Laura Rivera Méndez , Fabiola Almeida , Mario Ernesto Valdés Tresano , Yarini Arrebola Sánchez
REVISTA CUBANA DE CIENCIAS BIOLÓGICAS, 2020, 8 (2), pp.1-36
Journal articles hal-02944434v1
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Comparative Time-Scale Gene Expression Analysis Highlights the Infection Processes of Two Amoebophrya Strains

Sarah Farhat , Isabelle Florent , Benjamin Noël , Ehsan Kayal , Corinne da Silva
Frontiers in Microbiology, 2018, 9, ⟨10.3389/fmicb.2018.02251⟩
Journal articles hal-02126891v1
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Bile-Salt-Hydrolases from the Probiotic Strain Lactobacillus johnsonii La1 Mediate Anti-giardial Activity in Vitro and in Vivo

Thibault Allain , Soraya Chaouch , Myriam Thomas , Isabelle Vallée , André Buret
Frontiers in Microbiology, 2018, 8, pp.1-15. ⟨10.3389/fmicb.2017.02707⟩
Journal articles hal-02126890v1
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Bile Salt Hydrolase Activities: A Novel Target to Screen Anti-Giardia Lactobacilli?

Thibault Allain , Soraya Chaouch , Myriam Thomas , Marie-Agnès Travers , Isabelle Vallée
Frontiers in Microbiology, 2018, 9, ⟨10.3389/fmicb.2018.00089⟩
Journal articles hal-02126886v1

Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases

Emmanuel Salomon , Marjorie Schmitt , Anil Kumar Marapaka , Athanasios Stamogiannos , Germain Revelant
Molecules, 2018, 23 (10), pp.2607. ⟨10.3390/molecules23102607⟩
Journal articles hal-02128705v1
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Metallopeptidases of Toxoplasma gondii : in silico identification and gene expression

Sandie Escotte-Binet , Antoine Huguenin , Dominique Aubert , Anne-Pascaline Martin , Matthieu Kaltenbach
Parasite, 2018, 25, pp.26. ⟨10.1051/parasite/2018025⟩
Journal articles hal-03110320v1
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Aqueous extracts of marine invertebrates from Cuba coastline display neutral aminopeptidase inhibitory activities and effects on cancer cells and Plasmodium falciparum parasites

Isel Pascual Alonso , L Bounaadja , L Sánchez , L Rivera , Celine Tarnus
Indian Journal of Natural Products and Resources, 2017, 8 (2), pp.107-119
Journal articles hal-02154722v1

Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo

Lotfi Bounaadja , Marjorie Schmitt , Sébastien Albrecht , Elisabeth Mouray , Céline Tarnus
Malaria Journal, 2017, 16 (1), ⟨10.1186/s12936-017-2032-4⟩
Journal articles hal-02126893v1

KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library

Jorge Gonzales-Bazerio , Sarah El Chamy Maluf , Yanira Méndez , Isel Pascual , Isabelle Florent
Bioorganic and Medicinal Chemistry, 2017, 25 (17), pp.4628-4636. ⟨10.1016/j.bmc.2017.06.047⟩
Journal articles hal-02134397v1

Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN)

Isel Pascual , Pedro Valiente , Gabriela Garcia , Mario Valdés-Tresanco , Yarini Arrebola
Biochimie, 2017, 142 (5), pp.216-225. ⟨10.1016/j.biochi.2017.09.015⟩
Journal articles hal-02126895v1

Immunoglobulin response to the low polymorphic Pf113 antigen in children from Lastoursville, South-East of Gabon

Roméo Karl Imboumy-Limoukou , Sidney Maghendi-Nzondo , Charlene Lady Kouna , Lotfi Bounaadja , Sophie Mbang
Acta Tropica, 2016, 163, pp.149-156. ⟨10.1016/j.actatropica.2016.08.014⟩
Journal articles hal-01998452v1
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Ultrastructure of Selenidium pendula, the Type Species of Archigregarines, and Phylogenetic Relations to Other Marine Apicomplexa

Joseph Schrével , Andrea Valigurová , Gérard Prensier , Aurélie Chambouvet , Isabelle Florent
Protist, 2016, 167 (4), pp.339-368. ⟨10.1016/j.protis.2016.06.001⟩
Journal articles hal-01338422v1

A new lactobacilli in vivo expression system for the production and delivery of heterologous proteins at mucosal surfaces

Thibault Allain , Nahla M Mansour , May M. A. Bahr , Rebeca Martín , Isabelle Florent
FEMS Microbiology Letters, 2016, 363 (13), ⟨10.1093/femsle/fnw117⟩
Journal articles hal-02634544v1

Comparative antibody responses against three antimalarial vaccine candidate antigens from urban and rural exposed individuals in Gabon

Roméo-Karl Imboumy-Limoukou , Sandrine Lydie Oyegue-Liabagui , Stella Ndidi , Irène Pegha-Moukandja , Charlene Lady Kouna
European Journal of Microbiology and Immunology, 2016, 6 (4), pp.287-297. ⟨10.1556/1886.2016.00027⟩
Journal articles hal-02134412v1
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Deconjugated bile salts produced by extracellular bile-salt hydrolase-like activities from the probiotic Lactobacillus johnsonii La1 inhibit Giardia duodenalis in vitro growth

Marie-Agnès Travers , Cissé Sow , Séverine Zirah , Christiane Deregnaucourt , Soraya Chaouch
Frontiers in Microbiology, 2016, 7, pp.1-16. ⟨10.3389/fmicb.2016.01453⟩
Journal articles hal-02637819v1
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Diversity of apostome ciliates, Chromidina spp. (Oligohymenophorea, Opalinopsidae), parasites of cephalopods of the Mediterranean Sea

Dhikra Souidenne , Isabelle Florent , Marc Dellinger , Jean Lou Justine , Mohamed Salah Romdhane
Parasite, 2016, 23, pp.33. ⟨10.1051/parasite/2016033⟩
Journal articles hal-01368204v1

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Wesley van Voorhis , John Adams , Roberto Adelfio , Vida Ahyong , Myles Akabas
PLoS Pathogens, 2016, 12 (7), pp.e1005763. ⟨10.1371/journal.ppat.1005763⟩
Journal articles hal-02905407v1

Redescription of Dicyemennea eledones (Wagener, 1857) (Phylum Dicyemida) from Eledone cirrhosa (Lamarck, 1798) (Mollusca: Cephalopoda: Octopoda)

Dhikra Souidenne , Isabelle Florent , Marc Dellinger , Mohamed Salah Romdhane , Philippe Grellier
Systematic Parasitology, 2016, 93 (9), pp.905-915. ⟨10.1007/s11230-016-9659-3⟩
Journal articles hal-02134414v1
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Genetic impairment of parasite myosin motors uncovers the contribution of host cell membrane dynamics to Toxoplasma invasion forces

Marion Bichet , Bastien Touquet , Virginie Gonzalez , Isabelle Florent , Markus Meissner
BMC Biology, 2015, 14 (1), pp.97. ⟨10.1186/s12915-016-0316-8⟩
Journal articles inserm-01394800v1

Access to New Endoperoxide Derivatives by Electrochemical Oxidation of Substituted 3-Azabicyclo[4.1.0]hept-4-enes

Frédérick Nuter , Abdou Khadre Djily Dimé , Cheng Chen , Lotfi Bounaadja , Elisabeth Mouray
Chemistry - A European Journal, 2015, 21 (14), pp.5584-5593. ⟨10.1002/chem.201406138⟩
Journal articles hal-01178411v1

Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L.

Jane Namukobe , Bernard T Kiremire , Robert Byamukama , John M Kasenene , Vincent Dumontet
Phytochemistry, 2014, 102, pp.189-196. ⟨10.1016/j.phytochem.2014.02.005⟩
Journal articles hal-01005175v1
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Identification of divergent protein domains by combining HMM-HMM comparisons and co-occurrence detection

Amel Ghouila , Isabelle Florent , Fatma Zahra Guerfali , Nicolas Terrapon , Dhafer Laouini
PLoS ONE, 2014, 9 (6), pp.e95275. ⟨10.1371/journal.pone.0095275⟩
Journal articles pasteur-01060276v1
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Diversity and biological activities of the bacterial community associated with the marine sponge Phorbas tenacior (Porifera, Demospongiae).

S Dupont , Alyssa Carré-Mlouka , F Descarrega , Alexander Ereskovsky , A Longeon
Letters in Applied Microbiology, 2013, 58 (1), pp.42-52. ⟨10.1111/lam.12154⟩
Journal articles hal-01456679v1

Antimalarial screening via large-scale purification of Plasmodium falciparum Ca 2+ -ATPase 6 and in vitro studies

Stéphanie David-Bosne , Isabelle Florent , Anne-Marie Lund- Winther , John H. L. Hansen , Morten Buch-Pedersen
FEBS Journal, 2013, 280 (21), pp.5419-5429. ⟨10.1111/febs.12244⟩
Journal articles mnhn-02904306v1
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Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors

Rébecca F. Déprez-Poulain , Marion Flipo , Catherine Piveteau , Florence Leroux , Sandrine Dassonneville
Journal of Medicinal Chemistry, 2012, 55 (24), pp.10909-10917. ⟨10.1021/jm301506h⟩
Journal articles hal-03051765v1
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Probiotics for the Control of Parasites: An Overview

Marie-Agnès Travers , Isabelle Florent , Linda Kohl , Philippe Grellier
Journal of Parasitology Research, 2011, 2011, pp.1-11. ⟨10.1155/2011/610769⟩
Journal articles mnhn-02047396v1
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Bioinformatic strategies to provide functional clues to the unknown genes in Plasmodium falciparum genome

Isabelle Florent , Eric Maréchal , Olivier Gascuel , Laurent Brehelin
Parasite, 2010, 17 (4), pp.273-283. ⟨10.1051/parasite/2010174273⟩
Journal articles hal-02659756v1
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Assessing Functional Annotation Transfers with Inter-Species Conserved Coexpression: Application to Plasmodium Falciparum

Laurent Brehelin , Isabelle Florent , Olivier Gascuel , Eric Maréchal
BMC Genomics, 2010, 11 (35), pp.1471-2164. ⟨10.1186/1471-2164-11-35⟩
Journal articles lirmm-00540866v1

Aminocyclopropanes as precursors of endoperoxides with antimalarial activity

Claire Madelaine , Olivier Buriez , Benoit Crousse , Isabelle Florent , Philippe Grellier
Organic & Biomolecular Chemistry, 2010, 8 (24), pp.5591. ⟨10.1039/c0ob00308e⟩
Journal articles mnhn-02047403v1
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Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole

Omid Azimzadeh , Cissé Sow , Marc Gèze , Julius Nyalwidhe , Isabelle Florent
Malaria Journal, 2010, 9 (1), pp.189. ⟨10.1186/1475-2875-9-189⟩
Journal articles mnhn-02904304v1
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A Plasmodium Falciparum FcB1-Schizont-EST Collection Providing Clues to Schizont Specific Gene Structure and Polymorphism

Isabelle Florent , Betina M Porcel , Elodie Guillaume , Corinne da Silva , François Artiguenave
BMC Genomics, 2009, 10, pp.235-252. ⟨10.1186/1471-2164-10-235⟩
Journal articles lirmm-00395282v1
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Discovery of new targets for antimalarial chemotherapy

Philippe Grellier , Delphine Depoix , Joseph Schrével , I Florent
Parasite, 2008, 15 (3), pp.219-225. ⟨10.1051/parasite/2008153219⟩
Journal articles mnhn-02070082v1

Biochemical properties and cellular localization of Plasmodium falciparum protein disulfide isomerase

Elisabeth Mouray , Mireille Moutiez , S Girault , Christian Sergheraert , I Florent
Biochimie, 2007, 89 (3), pp.337-346. ⟨10.1016/j.biochi.2006.11.001⟩
Journal articles mnhn-02070098v1

Characterization of PfDYN2, a dynamin-like protein of Plasmodium falciparum expressed in schizonts

Sébastien Charneau , Izabela Bastos , Barbara Gomes Ribeiro , J.M. Santana , Philippe Grellier
Microbes and Infection, 2007, 9 (7), pp.797-805. ⟨10.1016/j.micinf.2007.02.020⟩
Journal articles mnhn-02070094v1

Novel Selective Inhibitors of the Zinc Plasmodial Aminopeptidase PfA-M1 as Potential Antimalarial Agents

Marion Flipo , Terence Beghyn , Virginie Leroux , Isabelle Florent , Benoit Déprez
Journal of Medicinal Chemistry, 2007, 50 (6), pp.1322-1334. ⟨10.1021/jm061169b⟩
Journal articles mnhn-02904302v1

Labelling of four distinct trophozoite falcipains of Plasmodium falciparum by a cystatin-derived probe

Isabelle Florent , Fabien Lecaille , Jean-Jacques Montagne , Francis Gauthier , Joseph Schrével
Biological Chemistry, 2005, 386 (4), pp.401 - 406. ⟨10.1515/BC.2005.048⟩
Journal articles mnhn-02904301v1

Plasmodium falciparum genes differentially expressed during merozoite morphogenesis.

I Florent , Sébastien Charneau , Philippe Grellier
Molecular and Biochemical Parasitology, 2004
Journal articles mnhn-02070129v1
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Design, synthesis and antimalarial activity of novel, quinoline-Based, zinc metallo-aminopeptidase inhibitors

Marian Flipo , Isabelle Florent , Philippe Grellier , Christian Sergheraert , Rebecca Déprez-Poulain
Bioorganic and Medicinal Chemistry Letters, 2003, 13 (16), pp.2659-2662. ⟨10.1016/S0960-894X(03)00550-X⟩
Journal articles mnhn-02867485v1

Plasmodium falciparum proteinases: cloning of the putative gene coding for the merozoite proteinase for erythrocyte invasion (MPEI) and determination of hydrolysis sites of spectrin by Pf37 proteinase

Isabelle Florent , S. Le Bonniec , B. Carcy , P. Grellier , O. Mercereau-Puijalon
Memórias do Instituto Oswaldo Cruz, 1994, 89 (suppl 2), pp.47-49. ⟨10.1590/s0074-02761994000600012⟩
Journal articles hal-03881542v1

Probiotics against Giardia, which therapeutic future?

Isabelle Florent , Bruno Polack , Luis Bermúdez-Humarán
12èmes journées du consortium anti-parasitaire et fongique « Zoonoses : évaluation des risques et stratégies thérapeutiques », CaPF, Apr 2023, Tours, France
Conference papers hal-04541065v1

Probiotics against Giardia in a One Health approach

Isabelle Florent , Bruno Polack , Luis Bermúdez-Humarán
Annual meeting of the European Veterinary Parasitology College, EVPC, Jun 2023, Maison Alfort, France
Conference papers hal-04541093v1

Giardia intestinalis, de l'homme à l'animal et vice & versa

Bruno Polack , Myriam Thomas , Isabelle Florent , Luis Bermúdez-Humarán
congrès annuel conjoint des Sociétés Françaises de Mycologie Médicale et de Parasitologie, Oct 2021, Lyon, France
Conference papers hal-04541459v1

Rôle des Bile Salt Hydrolases dans le contrôle de la Giardiose par des lactobacilles, in vitro et in vivo

Thibault Allain , Soraya Chaouch , Myriam Thomas , Isabelle Vallée , André G Buret
8èmes journées du consortium anti-parasitaire et fongique, CaPF, Mar 2018, Lyon, France
Conference papers hal-04541164v1

Probiotics against Giardia: a future therapeutic alternative?

Anne-Sophie Boucard , Philippe Langella , Bruno Polack , Isabelle Florent , Luis Bermúdez-Humaran
Lactic Acid Bacteria Biology, Symbioses and Applications Gordon Research Conference, Jul 2023, Ventura (CA), United States
Conference poster hal-04541448v1