Isabelle Fudal Dr Isabelle Fudal, INRAE Senior researcher, HDR

Identifiants chercheurs

IdHAL :

isabelle-fudal

ORCID :

0000-0002-9105-9432

IdRef :

080570232

Présentation

Address: Unité Bioger (UR 1290) Team Effecteurs et pathogenèse chez Leptosphaeria maculans Batiment F. Campus AgroParisTech. 22 place de l'agronomie. 91120 Palaiseau.

Contact : Tél. : +33 (0)6 80 78 46 33Mail : Isabelle.Fudal@inrae.fr

Research

I am a research scientist hired at INRA in the BIOGER unit in 2006, with a background in plant pathology, molecular biology and functional genomics. My main focus was, and still is, on deciphering fungal-plant interactions. Most of my research experience was devoted to understand fungal pathogenicity and signals produced by the fungus, which induce recognition of “non-self” and disease resistance (avirulence genes or effectors). Since I was hired as a permanent scientist at INRA, I am developing functional genomics approaches on plant-fungi interactions with a particular interest to fungal effectors on the model of interaction Leptosphaeria maculans / Brassica napus. The objective of my research project is to study the possible roles of effectors on pathogenicity towards B. napus (identification, expression, regulation, evolution and functional analysis). To achieve this goal, I develop a pluri-disciplinary project combining bioinformatics, transcriptomics, functional genomics, pathogenicity studies and evolutionary genomics. Recently, I focused part of my researches on the determinism of concerted regulation of effector genes during infection and pointed out on the importance of chromatin status in this regulation. I am co-leading the INRA SPE network REacTION (network on the epigenetic mechanisms that shape plant - Bioaggressors and Symbiotic Organisms interactions)

Curriculum vitae

Since 2020

INRAE Senior Researcher, UMR1290 BIOGER, Grignon

2014

HDR, Université Paris-Sud, Orsay

2006-2019

INRA Researcher Scientist, UMR1290 Bioger, INRA, Grignon

2004-2006

Postdoc, Unité PMDV, INRA, Versailles

2000-2004

PhD, Université Paris-Sud, Orsay

1999-2000

Master Biologie, Diversité et Adaptation des Plantes Cultivées : option Phytopathologie (Paris)

1997- 2000

Engineer degree, Institut National Agronomique Paris-Grignon (INA P-G, Paris)

Publications

Article dans une revue (40)

Conserved ‘Late’ Effector Genes From Leptosphaeria maculans Inducing Gene‐For‐Gene Quantitative Resistance in Brassica napus Semi‐Winter Genotypes Camille Rabeau,Armand Wagner,Nicolas Lapalu,Audren Jiquel,Sébastien Faureet al. Molecular Plant Pathology, 2026, 27 (3), pp.e70224. ⟨10.1111/mpp.70224⟩ Article dans une revue hal-05591916v1
Molecular Investigation of Rlm3 From Rapeseed as a Potential Broad‐Spectrum Resistance Gene Against Fungal Pathogens Producing Structurally Conserved Effectors Nacera Talbi,Simine Pakzad,Françoise Blaise,Bénédicte Ollivier,Thierry Rouxelet al. Plant Pathology, 2025, ⟨10.1111/ppa.70063⟩ Article dans une revue hal-05274184v1
Regulation of effector gene expression as concerted waves in Leptosphaeria maculans : a two‐player game Colin Clairet,Elise Gay,Antoine Porquier,Françoise Blaise,Claire‐line Maraiset al. New Phytologist, 2024, 242 (1), pp.247-261. ⟨10.1111/nph.19581⟩ Article dans une revue hal-04480387v1
Facilitation of symplastic effector protein mobility by paired effectors is conserved in different classes of fungal pathogens Nacera Talbi,Mila Blekemolen,Slavica Janevska,Daniel Zendler,Herman van Tilbeurghet al. Molecular Plant-Microbe Interactions, 2024, 37 (3), pp.304-314. ⟨10.1094/MPMI-07-23-0103-FI⟩ Article dans une revue hal-04232770v1
Improving sustainable crop protection using population genetics concepts Méline Saubin,Clémentine Louet,Lydia Bousset,Frédéric Fabre,Pascal Freyet al. Molecular Ecology, 2023, 32 (10), pp.2461-2471. ⟨10.1111/mec.16634⟩ Article dans une revue (article de synthèse) hal-03394837v2
The neighbouring genes AvrLm10A and AvrLm10B are part of a large multigene family of cooperating effector genes conserved in Dothideomycetes and Sordariomycetes Nacera Talbi,Like Fokkens,Corinne Audran,Yohann Petit-Houdenot,Cécile Pouzetet al. Molecular Plant Pathology, 2023, 24, pp.914-931. ⟨10.1111/MPP.13338⟩ Article dans une revue hal-04090329v1
Nucleosome patterns in four plant pathogenic fungi with contrasted genome structures Colin Clairet,Nicolas Lapalu,Adeline Simon,Jessica Soyer,Muriel Viaudet al. Peer Community Journal, 2023, 3, pp.e13. ⟨10.24072/pcjournal.227⟩ Article dans une revue hal-04088414v1
A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins Noureddine Lazar,Carl Mesarich,Yohann Petit-Houdenot,Nacera Talbi,Ines Li de La Sierra-Gallayet al. PLoS Pathogens, 2022, 18 (7), pp.e1010664. ⟨10.1371/journal.ppat.1010664⟩ Article dans une revue hal-03324327v1
Large-scale transcriptomics to dissect 2 years of the life of a fungal phytopathogen interacting with its host plant Elise J Gay,Jessica L Soyer,Nicolas Lapalu,Juliette Linglin,Isabelle Fudalet al. BMC Biology, 2021, 19 (1), pp.e041118. ⟨10.1186/s12915-021-00989-3⟩ Article dans une revue hal-03190704v1
Genome-wide mapping of histone modifications during axenic growth in two species of Leptosphaeria maculans showing contrasting genomic organization Jessica Soyer,Colin Clairet,Elise Gay,Nicolas Lapalu,Thierry Rouxelet al. Chromosome Research, 2021, 29 (2), pp.219-236. ⟨10.1007/s10577-021-09658-1⟩ Article dans une revue hal-03266749v1
A gene‐for‐gene interaction involving a ‘late’ effector contributes to quantitative resistance to the stem canker disease in Brassica napus Audren Jiquel,Julie Gervais,Aude Geistodt‐kiener,Régine Delourme,Elise Gayet al. New Phytologist, 2021, 231 (4), pp.1510-1524. ⟨10.1111/nph.17292⟩ Article dans une revue hal-03155959v1
A new avirulence gene of Leptosphaeria maculans , AvrLm14 , identifies a resistance source in American broccoli ( Brassica oleracea ) genotypes Alexandre A. Degrave,Marine Wagner,Pierre George,Laurent Coudard,Xavier Pinochetet al. Molecular Plant Pathology, 2021, 22 (12), pp.1599-1612. ⟨10.1111/mpp.13131⟩ Article dans une revue hal-03344127v1
Apoplastic effector proteins of plant-associated fungi and oomycetes Mercedes Rocafort,Isabelle Fudal-Grolier Fudal,Carl Mesarich Current Opinion in Plant Biology, 2020, 56, pp.9-19. ⟨10.1016/j.pbi.2020.02.004⟩ Article dans une revue hal-02894839v1
A two genes – for – one gene interaction between Leptosphaeria maculans and Brassica napus Yohann Petit-Houdenot,Alexandre A. Degrave,Michel Meyer,Françoise Blaise,Bénédicte Ollivieret al. New Phytologist, 2019, 223 (1), pp.397-411. ⟨10.1111/nph.15762⟩ Article dans une revue hal-02278749v1
The genome biology of effector gene evolution in filamentous plant pathogens Andrea Sanchez-Vallet,Simone Fouche,Isabelle Fudal,Fanny E. Hartmann,Jessica L Soyeret al. Annual Review of Phytopathology, 2018, 56, ⟨10.1146/annurev-phyto-080516-035303⟩ Article dans une revue (article de synthèse) hal-02628719v1
Effector Biology in Fungal Pathogens of Nonmodel Crop Plants Isabelle Fudal,Marie-Helene Balesdent,Thierry Rouxel Trends in Plant Science, 2018, 23 (9), pp.753 - +. ⟨10.1016/j.tplants.2018.07.002⟩ Article dans une revue istex hal-02626782v1
Complex Interactions between Fungal Avirulence Genes and Their Corresponding Plant Resistance Genes and Consequences for Disease Resistance Management Yohann Petit,Isabelle Fudal Frontiers in Plant Science, 2017, 8, ⟨10.3389/fpls.2017.01072⟩ Article dans une revue hal-01602583v1
Different waves of effector genes with contrasted genomic location are expressed by Leptosphaeria maculans during cotyledon and stem colonization of oilseed rape Julie Gervais,Clémence Plissonneau,Juliette Linglin,Michel Meyer,Karine Labadieet al. Molecular Plant Pathology, 2017, 18 (8), pp.1113 - 1126. ⟨10.1111/mpp.12464⟩ Article dans une revue hal-01608614v1
The N-end rule pathway regulates pathogen responses in plants Rémi de Marchi,Maud Sorel,Brian Mooney,Isabelle Fudal-Grolier Fudal,Kevin Goslinet al. Scientific Reports, 2016, 6 (1), ⟨10.1038/srep26020⟩ Article dans une revue hal-02104524v1
A game of hide and seek between avirulence genes AvrLm4‐7 and AvrLm3 in Leptosphaeria maculans Clémence Plissonneau,Guillaume Daverdin,Bénédicte Ollivier,Françoise Blaise,Alexandre A. Degraveet al. New Phytologist, 2016, 209 (4), pp.1613-1624. ⟨10.1111/nph.13736⟩ Article dans une revue hal-02516669v1
Chromatin-based control of effector gene expression in plant-associated fungi Jessica L. Soyer,Thierry T. Rouxel,Isabelle Fudal-Grolier Fudal Current Opinion in Plant Biology, 2015, 26, pp.51-56. ⟨10.1016/j.pbi.2015.05.025⟩ Article dans une revue istex hal-02638628v1
Crystal structure of the effector AvrLm4-7 of Leptosphaeria maculans reveals insights into its translocation into plant cells and recognition by resistance proteins. Karine Blondeau,Françoise Blaise,Marc Graille,Shiv D Kale,Juliette Linglinet al. The Plant Journal, 2015, 83 (4), pp.610-24. ⟨10.1111/tpj.12913⟩ Article dans une revue hal-01446655v1
The APSES transcription factor LmStuA is required for sporulation, pathogenic development and effector gene expression in Leptosphaeria maculans Jessica Louise Soyer,Audrey Hamiot,Benedicte Ollivier,Marie-Helene Balesdent,Thierry Rouxelet al. Molecular Plant Pathology, 2015, 16 (9), pp.1000-1005. ⟨10.1111/mpp.12249⟩ Article dans une revue hal-01536499v1
Rapid identification of the Leptosphaeria maculans avirulence gene AvrLm2 using an intraspecific comparative genomics approach Kaveh Ghanbarnia,Isabelle Fudal,Nicholas J. Larkan,Matthew G. Links,Marie-Helene Balesdentet al. Molecular Plant Pathology, 2015, 16 (7), pp.699 - 709. ⟨10.1111/mpp.12228⟩ Article dans une revue hal-01536462v1
Quantitative resistance affects the speed of frequency increase but not the diversity of the virulence alleles overcoming a major resistance gene to [i]Leptosphaeria maculans[/i] in oilseed rape Régine Delourme,Lydia Bousset,Magali Ermel,Philippe Duffe,Anne-Laure Besnardet al. Infection, Genetics and Evolution, 2014, 27, pp.490-499. ⟨10.1016/j.meegid.2013.12.019⟩ Article dans une revue istex hal-01208690v1
Epigenetic Control of Effector Gene Expression in the Plant Pathogenic Fungus [i]Leptosphaeria maculans[/i] Jessica Soyer,Mennat El Ghalid,Nicolas Glaser,Bénédicte Ollivier,Juliette Linglinet al. PLoS Genetics, 2014, 10 (3), 19 p. ⟨10.1371/journal.pgen.1004227⟩ Article dans une revue hal-01019254v1
Transposable element-assisted evolution and adaptation to host plant within the Leptosphaeria maculans-Leptosphaeria biglobosa species complex of fungal pathogens Jonathan J. Grandaubert,Rohan G.T. Lowe,Jessica L. Soyer,C.L. Schoch,Angela P van de Wouwet al. BMC Genomics, 2014, 15 (891), pp.OA. ⟨10.1186/1471-2164-15-891⟩ Article dans une revue hal-02631920v1
Microbe-Independent Entry of Oomycete RxLR Effectors and Fungal RxLR-Like Effectors Into Plant and Animal Cells Is Specific and Reproducible Brett M. B. M. Tyler,Shiv D. S. D. Kale,Qunqing Q. Wang,Kai K. Tao,Helen R. H. R. Clarket al. Molecular Plant-Microbe Interactions, 2013, 26 (6), pp.611 - 616. ⟨10.1094/mpmi-02-13-0051-ia⟩ Article dans une revue hal-01001070v1
The dispensable chromosome of Leptosphaeria maculans shelters an effector gene conferring avirulence towards Brassica rapa. Marie-Helene Balesdent,Isabelle Fudal-Grolier Fudal,Bénédicte B. Ollivier,Pascal P. Bally,Jonathan J. Grandaubertet al. New Phytologist, 2013, 198 (3), pp.887-898. ⟨10.1111/nph.12178⟩ Article dans une revue hal-01004245v1
Genome Structure and Reproductive Behaviour Influence the Evolutionary Potential of a Fungal Phytopathogen Guillaume Daverdin,Thierry Rouxel,Lilian Gout,Jean-Noël Aubertot,Isabelle Fudalet al. PLoS Pathogens, 2012, 8 (11), 15 p. ⟨10.1371/journal.ppat.1003020⟩ Article dans une revue hal-01019027v1
Incidence of Genome Structure, DNA Asymmetry, and Cell Physiology on T-DNA Integration in Chromosomes of the Phytopathogenic Fungus Leptosphaeria maculans Ahmed Salim A. S. Bourras,Michel M. Meyer,Jonathan J. Grandaubert,Nicolas Lapalu,Isabelle Fudal-Grolier Fudalet al. G3, 2012, 2 (8), pp.891-904. ⟨10.1534/g3.112.002048⟩ Article dans une revue hal-01000638v1
Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations Thierry Rouxel,J. Grandaubert,Jk. Hane,Claire Hoede,Angela P. van de Wouwet al. Nature Communications, 2011, 2, pp.202. ⟨10.1038/ncomms1189⟩ Article dans une revue hal-00841751v1
External lipid P13P mediates entry of eukaryotic pathogen effectors into plant and animal host cells Shiv D. Kale,Biao Gu,Daniel G.S. Capelluto,Daolong Dou,Emily Feldmanet al. Cell, 2010, 142 (2), pp.284-295. ⟨10.1016/j.cell.2010.06.008⟩ Article dans une revue hal-02667928v1
Leptosphaeria maculans avirulence gene AvrLm4-7 confers a dual recognition specificity by the Rlm4 and Rlm7 resistance genes of oilseed rape and circumvents Rlm4-mediated recognition through a single amino acid change Francis Parlange,Guillaume G. Daverdin,Marie-Line Kuhn,Isabelle Fudal-Grolier Fudal,Marie-Helene Balesdentet al. Molecular Microbiology, 2009, 71 (4), pp.851-863. ⟨10.1111/j.1365-2958.2008.06547.x⟩ Article dans une revue hal-02663864v1
Repeat-induced point mutation (RIP) as an alternative mechanism of evolution toward virulence in Leptosphaeria maculans Isabelle Fudal-Grolier Fudal,Simon Ross,Hortense H. Brun,Anne-Laure Besnard,Magali M. Ermelet al. Molecular Plant-Microbe Interactions, 2009, 22 (8), pp.932-941. ⟨10.1094/MPMI-22-8-0932⟩ Article dans une revue hal-02667764v1
Magnaporthe grisea avirulence gene ACE1 belons to an infection-specific gene cluster involved in secondary metabolism Jérôme Collemare,Mikaël Pianfetti,Anne-Élodie Houlle,Damien Morin,Laurent Cambordeet al. New Phytologist, 2008, Pathogenic plant–fungus interactions, 179 (1), pp.196-208. ⟨10.1111/j.1469-8137.2008.02459.x⟩ Article dans une revue hal-02669102v1
Heterochromatin-like regions as ecological niches for avirulence genes in the Leptosphaeria maculans genome : map-based cloning of AvrLm6 Isabelle Fudal-Grolier Fudal,S Ross,Lilian L. Gout,Francoise F. Blaise,Marie-Line Kuhnet al. Molecular Plant-Microbe Interactions, 2007, 20 (4), pp.459-470. ⟨10.1094/MPMI-20-4-0459⟩ Article dans une revue hal-02656853v1
Expression of Magnaporthe grisea Avirulence Gene ACE1 Is Connected to the Initiation of Appressorium-Mediated Penetration Isabelle Fudal,Jérôme Collemare,Heidi U. Böhnert,Delphine Melayah,Marc-Henri Lebrun Eukaryotic Cell, 2007, 6 (3), pp.546-554. ⟨10.1128/EC.00330-05⟩ Article dans une revue halsde-00180977v1
Lost in the middle of nowhere: the AvrLm1 avirulence gene of the dothideomycete Leptosphaeria maculans Lilian L. Gout,Isabelle Fudal-Grolier Fudal,Marie-Line Kuhn,Francoise F. Blaise,Maria Eckertet al. Molecular Microbiology, 2006, 60 (1), pp.67-80. ⟨10.1111/j.1365-2958.2006.05076.x⟩ Article dans une revue hal-02662679v1
Origins of host-specific populations of the blast pathogen Magnaporthe oryzae in crop domestication with subsequent expansion of pandemic clones on rice and weeds of rice Brett C Couch,Isabelle Fudal,Marc-Henri M.-H. Lebrun,Didier Tharreau,Barbara Valentet al. Genetics, 2005, 170 (2), pp.613-630. ⟨10.1534/genetics.105.041780⟩ Article dans une revue hal-02681928v1

Chapitre d'ouvrage (7)

Mécanismes épigénétiques des interactions hôte-agent pathogène Christoph Grunau,Isabelle Fudal,Nadia Ponts Hélène Jammes; Pierre Boudry; Stéphane Maury. Epigénétique. Mécanismes moléculaires, biologie du développement et réponses à l'environnement, Editions Quae, pp.133-144, 2024, 978-2-7592-3769-2 Chapitre d'ouvrage hal-04613807v1
Epigenetic regulation of fungal genes involved in plant colonization Jessica L. Soyer,Isabelle Fudal The Mycota, Plant Relationships / Fungal – plant interactions., 5, springer, pp.255-281, 2023, ⟨10.1007/978-3-031-16503-0⟩ Chapitre d'ouvrage hal-04432844v1
La méthylation de l’ADN Isabelle Fudal,Nadia Ponts Principes des techniques de biologie moléculaire et génomique : 3e édition revue et augmentée, Quae, 2018, Savoir Faire, 978-2-7592-2389-3 Chapitre d'ouvrage hal-04567334v1
Techniques d’identification de régions génomiques accessibles à des régulateurs : FAIRE et ATAC Isabelle Fudal,Nadia Ponts Principes des techniques de biologie moléculaire et génomique : 3e édition revue et augmentée, Quae, 2018, Savoir Faire, 978-2-7592-2389-3 Chapitre d'ouvrage hal-04567382v1
Méthode de détermination du positionnement des nucléosomes : MAINE Isabelle Fudal,Nadia Ponts Principes des techniques de biologie moléculaire et génomique : 3e édition revue et augmentée, Quae, 2018, Savoir Faire, 978-2-7592-2389-3 Chapitre d'ouvrage hal-04567389v1
Structure de la chromatine Isabelle Fudal,Nadia Ponts Principes des techniques de biologie moléculaire et génomique : 3e édition revue et augmentée, Quae, 2018, Savoir Faire, 978-2-7592-2389-3 Chapitre d'ouvrage hal-04567393v1
Immunoprécipitation de la chromatine Isabelle Fudal,Nadia Ponts Principes des techniques de biologie moléculaire et génomique : 3e édition revue et augmentée, Quae, 2018, Savoir Faire, 978-2-7592-2389-3 Chapitre d'ouvrage hal-04567380v1

Pré-publication, Document de travail (4)

Molecular investigation of Rlm3 from rapeseed as a broad-spectrum resistance gene against fungal pathogens producing structurally conserved effectors Nacera Talbi,Simine Pakzad,Françoise Blaise,Bénédicte Ollivier,Thierry Rouxelet al. 2025 Pré-publication, Document de travail hal-05250861v1
Conserved &quot;late&quot; effector genes from Leptosphaeria maculans inducing gene-for-gene quantitative resistance in Brassica napus semi-winter genotypes Camille Rabeau,Armand Wagner,Nicolas Lapalu,Audren Jiquel,Sébastien Faureet al. 2025 Pré-publication, Document de travail hal-05303489v1
Regulation of effector gene expression as concerted waves in Leptosphaeria maculans : a two-players game C. Clairet,E.J. Gay,A. Porquier,F. Blaise,C.L. Maraiset al. 2023 Pré-publication, Document de travail hal-04088422v1
Nucleosome patterns in four plant pathogenic fungi with contrasted genome structures Colin Clairet,Nicolas Lapalu,Adeline Simon,Jessica Soyer,Muriel Viaudet al. 2021 Pré-publication, Document de travail hal-03324321v1

HDR (1)

Génomique fonctionnelle des interactions plantes / champignons Isabelle Fudal-Grolier Fudal Sciences du Vivant [q-bio]. Université Paris Sud - Paris 11, 2014 HDR tel-02801567v1