Isabelle PLO

Documents

Publications

	Deregulation of the p19/CDK4/CDK6 axis in Jak2V617F megakaryocytes accelerates the development of myelofibrosis Hélène Duparc , Delphine Muller , Laure Gilles , Agathe Chédeville , Mira El Khoury Leukemia, 2024, ⟨10.1038/s41375-024-02170-5⟩ Journal articles hal-04471457v1
	The double-edged sword of adenosine Isabelle Plo , Iléana Antony-Debré Haematologica, 2023, ⟨10.3324/haematol.2023.283469⟩ Journal articles hal-04427016v1
	Optimizing IFN Alpha Therapy against Myeloproliferative Neoplasms Gurvan Hermange , Paul-Henry Cournède , Isabelle Plo Journal of Pharmacology and Experimental Therapeutics, 2023, 387 (1), pp.31-43. ⟨10.1124/jpet.122.001561⟩ Journal articles hal-04308358v1
	When monoclonal gammopathy‐associated chronic neutrophilic leukemia is a reactive process distinct from a clonal myeloproliferative neoplasm: Lessons from mistakes Christophe Willekens , Claude Chahine , Matteo Dragani , Sabine Khalife-Hachem , Camille Bigenwald eJHaem, 2023, 4 (3), pp.823-826. ⟨10.1002/jha2.713⟩ Journal articles hal-04441619v1
	Targeting PP2A-dependent autophagy enhances sensitivity to ruxolitinib in JAK2V617F myeloproliferative neoplasms Charly Courdy , Loïc Platteeuw , Charlotte Ducau , Isabelle de Araujo , Emeline Boet Blood Cancer Journal, 2023, 13 (1), pp.106. ⟨10.1038/s41408-023-00875-x⟩ Journal articles hal-04430069v1
	Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms Christian Pecquet , Nicolas Papadopoulos , Thomas Balligand , Ilyas Chachoua , Amandine Tisserand Blood, 2023, 141 (8), pp.917-929. ⟨10.1182/blood.2022016846⟩ Journal articles hal-04429999v1
	SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice Christophe Willekens , Lucie Laplane , Tracy Dagher , Camelia Benlabiod , Nicolas Papadopoulos Leukemia, 2023, 37 (6), pp.1287-1297. ⟨10.1038/s41375-023-01878-0⟩ Journal articles hal-04430024v1
	Altered Ca2+ Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis Ralfs Buks , Tracy Dagher , Maria Giustin Rotordam , David Monedero Alonso , Sylvie Cochet Cells, 2022, 11 (1), pp.49. ⟨10.3390/cells11010049⟩ Journal articles hal-03523607v1
	Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model Brahim Arkoun , Elie Robert , Fabien Boudia , Stefania Mazzi , Virginie Dufour The Journal of clinical investigation, 2022, 132 (14), pp.131-136. ⟨10.1172/JCI156290⟩ Journal articles hal-04441606v1
	Modélisation mathématique de l'hématopoïèse et des hémopathies : développement, dynamique et traitement Gurvan Hermange , Paul-Henry P.-H. Cournède , Isabelle Plo Hématologie, 2022, 28 (4), pp.183-200. ⟨10.1684/hma.2022.1762⟩ Journal articles hal-04134893v1
	Inferring the initiation and development of myeloproliferative neoplasms Gurvan Hermange , Alicia Rakotonirainy , Mahmoud Bentriou , Amandine Tisserand , Mira El-Khoury Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (37), ⟨10.1073/pnas.2120374119⟩ Journal articles hal-03844872v1
	An inherited gain‐of‐function risk allele in EPOR predisposes to familial JAK2 V617F myeloproliferative neoplasms Graciela Rabadan Moraes , Florence Pasquier , Christophe Marzac , Eric Deconinck , Carlotta Caterina Damanti British Journal of Haematology, 2022, ⟨10.1111/bjh.18165⟩ Journal articles hal-03638075v1
	Dual role of EZH2 in megakaryocyte differentiation Stefania Mazzi , Philippe Dessen , Mathieu Vieira , Virginie Dufour , Marie Cambot Blood, 2021, 138 (17), pp.1603-1614. ⟨10.1182/blood.2019004638⟩ Journal articles hal-03448744v1
	Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms Lise Secardin , Cintia Gomez Limia , Suzana da Silva-Benedito , Larissa Lordier , Mira El-Khoury HemaSphere, 2021, 5 (7), pp.e593. ⟨10.1097/HS9.0000000000000593⟩ Journal articles hal-04429987v1
	Inferring the dynamic of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms Matthieu Mosca , Gurvan Hermange , Amandine Tisserand , Robert John Noble , Christophe Marzac Blood, 2021, ⟨10.1182/blood.2021010986⟩ Journal articles hal-03452002v1
	Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms Lise Secardin , Cintia Gomez Limia , Suzana da Silva-Benedito , Larissa Lordier , Mira El-Khoury HemaSphere, 2021, 5 (7), pp.e593. ⟨10.1097/HS9.0000000000000593⟩ Journal articles hal-03263690v1
	Identification of biallelic germline variants of SRP68 in a sporadic case with severe congenital neutropenia Barbara Schmaltz-Panneau , Anne Pagnier , Séverine Clauin , Julien Buratti , Caroline Marty Haematologica, 2021, 106 (4), pp.1216-1219. ⟨10.3324/haematol.2020.247825⟩ Journal articles hal-03243114v1
	Germline ATG2B/GSKIP-containing 14q32 duplication predisposes to early clonal hematopoiesis leading to myeloid neoplasms Jean Pegliasco , Pierre Hirsch , Christophe Marzac , Françoise Isnard , Jean-Côme Meniane Leukemia, 2021, 36 (1), pp.126-137. ⟨10.1038/s41375-021-01319-w⟩ Journal articles hal-04441339v1
	HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity Tamar Tak , Giulio Prevedello , Gaël Simon , Noémie Paillon , Camélia Benlabiod eLife, 2021, 10, ⟨10.7554/elife.60624⟩ Journal articles hal-03266494v2
	PPARγ agonists promote the resolution of myelofibrosis in preclinical models Juliette Lambert , Joseph Saliba , Carolina Calderon , Karine Sii-Felice , Mohammad Salma The Journal of clinical investigation, 2021, 131 (11), ⟨10.1172/JCI136713⟩ Journal articles hal-04429976v1
	IFN: Jekyll and Hyde Isabelle Plo , William Vainchenker Blood, 2021, 137 (3), pp.291-293. ⟨10.1182/blood.2020008560⟩ Journal articles hal-04441320v1
	CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag Francesca Basso-Valentina , Gabriel Levy , Leila Varghese , Myriam Oufadem , Benedicte Neven Blood, 2021, 138 (6), pp.480-485. ⟨10.1182/blood.2020010567⟩ Journal articles hal-04429984v1
	Lyl-1 regulates primitive macrophages and microglia development Shoutang Wang , Deshan Ren , Brahim Arkoun , Anna-Lila Kaushik , Gabriel Matherat Communications Biology, 2021, 4 (1), pp.1382. ⟨10.1038/s42003-021-02886-5⟩ Journal articles hal-04441591v1
	Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms Mira El-Khoury , Xénia Cabagnols , Matthieu Mosca , Gaëlle Vertenoeil , Christophe Marzac Oncogene, 2020, 39 (31), pp.5323-5337. ⟨10.1038/s41388-020-1368-3⟩ Journal articles hal-04429967v1
	TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells Lise Secardin , Cintia Elisabeth Gomez Limia , Antonio Di Stefano , Martin Hernan Bonamino , Joseph Saliba Stem Cell Research, 2020, 44, pp.101755. ⟨10.1016/j.scr.2020.101755⟩ Journal articles hal-04429959v1
	Induced pluripotent stem cells and hematological malignancies: A powerful tool for disease modeling and drug development A. Donada , F. Basso-Valentina , B. Arkoun , B. Monte-Mor , Isabelle Plo Stem Cell Research, 2020, 49 (2), pp.102060. ⟨10.1016/j.scr.2020.102060⟩ Journal articles hal-04441319v1
	Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN Camélia Benlabiod , Maira da Costa Cacemiro , Audrey Nédélec , Valérie Edmond , Delphine Muller Nature Communications, 2020, 11 (1), pp.4886. ⟨10.1038/s41467-020-18691-3⟩ Journal articles hal-04429972v1
	Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients with myeloproliferative neoplasms Christian Di Buduo , Vittorio Abbonante , Caroline Marty , Francesco Moccia , Elisa Rumi Blood, 2020, 135 (2), pp.133-144. ⟨10.1182/blood.2019001103⟩ Journal articles hal-04430037v1
	JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML Tracy Dagher , Nabih Maslah , Valérie Edmond , Bruno Cassinat , William Vainchenker Journal of Experimental Medicine, 2020, 218, ⟨10.1084/jem.20201268⟩ Journal articles hal-04055414v1
	Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms Mira El-Khoury , Xénia Cabagnols , Matthieu Mosca , Gaëlle Vertenoeil , Christophe Marzac Oncogene, 2020, 39 (31), pp.5323-5337. ⟨10.1038/s41388-020-1368-3⟩ Journal articles hal-04438597v1
	Surface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosis Oliver Kepp , Peng Liu , Liwei Zhao , Isabelle Plo , Guido Kroemer OncoImmunology, 2020, 9 (1), pp.5323-5337. ⟨10.1080/2162402X.2020.1792037⟩ Journal articles hal-04441316v1
	Germline genetic factors in the pathogenesis of myeloproliferative neoplasms Christine Bellanné-Chantelot , Graciela Rabadan Moraes , Barbara Schmaltz-Panneau , Caroline Marty , William Vainchenker Blood Reviews, 2020, 42, pp.100710 -. ⟨10.1016/j.blre.2020.100710⟩ Journal articles hal-03491411v1
	Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells Olivier Mansier , Badr Kilani , Amélie V. Guitart , Alexandre Guy , Virginie Gourdou-Latyszenok Blood, 2019, 134 (26), pp.2383-2387. ⟨10.1182/blood.2019001163⟩ Journal articles hal-03194452v1
	MCM8-and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53- Dependent Myeloid Tumors Malik Lutzmann , Florence F. Bernex , Cindy da Costa de Jesus , Dana Hodroj , Caroline Marty Cell Reports, 2019, 28 (11), pp.2851 - 2865. ⟨10.1016/j.celrep.2019.07.095⟩ Journal articles hal-02397140v1
	Not just another kinase mutation! Isabelle Plo , Caroline Marty Blood, 2019, 134 (26), pp.2335-2337. ⟨10.1182/blood.2019003650⟩ Journal articles hal-04430049v1
	Inherited transmission of the CSF3R T618I mutational hotspot in familial chronic neutrophilic leukemia Nicolas Duployez , Christophe Willekens , Isabelle Plo , Alice Marceau-Renaut , Stéphane de Botton Blood, 2019, 134 (26), pp.2414-2416. ⟨10.1182/blood.2019003206⟩ Journal articles hal-04441297v1
	Impact of interferon on a triple positive polycythemia vera Hugo Campario , Matthieu Mosca , Bernard Aral , Valentin Bourgeois , Pauline Martin Leukemia, 2019, 34 (4), pp.1210-1212. ⟨10.1038/s41375-019-0636-0⟩ Journal articles hal-04441302v1
	Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells Olivier Mansier , Badr Kilani , Amelie V Guitart , Alexandre Guy , Virginie Gourdou-Latyszenok Blood, 2019, 134 (26), pp.2383-2387. ⟨10.1182/blood.2019001163⟩ Journal articles hal-04140431v1
	Disrupted filamin A/αIIbβ3 interaction induces macrothrombocytopenia by increasing RhoA activity Alessandro Donada , Nathalie Balayn , Dominika Sliwa , Larissa Lordier , Valentina Ceglia Blood, 2019, 133 (16), pp.1778-1788. ⟨10.1182/blood-2018-07-861427⟩ Journal articles hal-04441275v1
	Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells Olivier Mansier , Badr Kilani , Amélie Guitart , Alexandre Guy , Virginie Gourdou-Latyszenok Blood, 2019, 134 (26), pp.2383-2387. ⟨10.1182/blood.2019001163⟩ Journal articles hal-04429945v1
	Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond–like syndrome Christine Bellanné-Chantelot , Barbara Schmaltz-Panneau , Caroline Marty , Odile Fenneteau , Isabelle Callebaut Blood, 2018, 132 (12), pp.1318-1331. ⟨10.1182/blood-2017-12-820308⟩ Journal articles hal-04429910v1
	Specific and Synergistic Targeting of JAK2V617F Cells By Interferon Alpha and Arsenic Tracy Dagher , Valérie Edmond , Bruno Cassinat , Valérie Lallemand-Breitenbach , Emmanuelle Verger Blood, 2018, 132 (Supplement 1), pp.52-52. ⟨10.1182/blood-2018-99-112518⟩ Journal articles hal-04055417v1
	Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond–like syndrome Christine Bellanné-Chantelot , Barbara Schmaltz-Panneau , Caroline Marty , Odile Fenneteau , Isabelle Callebaut Blood, 2018, 132 (12), pp.1318-1331. ⟨10.1182/blood-2017-12-820308⟩ Journal articles hal-02343565v1
	HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis Margaux Sevin , Lucia Kubovcakova , Nicolas Pernet , Sebastien Causse , Franck Vitte Nature Communications, 2018, 9 (1), pp.1431. ⟨10.1038/s41467-018-03627-9⟩ Journal articles hal-01864299v1
	New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis Florence Pasquier , Caroline Marty , Thomas Balligrand , Frédérique Verdier , Sarah Grosjean Haematologica, 2017, ⟨10.3324/haematol.2017.176370⟩ Journal articles hal-02403399v1
	A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma Elias A El-Habr , Gustavo Luiz Dubois , Fanny Burel-Vandenbos , Alexandra Bogeas , Joanna Lipecka Acta Neuropathologica, 2017, 133 (4), pp.645-660. ⟨10.1007/s00401-016-1659-5⟩ Journal articles inserm-01481051v1
	Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect Isabelle Godin , Kahia Messaoudi , Ashfaq Ali , Rameez Ishaq , Alberta Palazzo Nature Communications, 2017, 8, ⟨10.1038/s41467-017-01690-2⟩ Journal articles hal-02992921v1
	CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner Hadjer Abdelouahab , Yanyan Zhang , Monika Wittner , Shinya Oishi , Nobutaka Fujii Oncotarget, 2017, 8 (33), ⟨10.18632/oncotarget.10789⟩ Journal articles hal-02380531v1
	Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0 Vladimir T. Manchev , Hind Bouzid , Iléana Antony-Debré , Betty Leite , Guillaume Meurice Journal of Cellular and Molecular Medicine, 2017, 21 (6), pp.1237 - 1242. ⟨10.1111/jcmm.13051⟩ Journal articles hal-01537098v1
	Identification of MPL R102P Mutation in Hereditary Thrombocytosis Christine Bellanne-Chantelot , Matthieu Mosca , Caroline Marty , Rémi Favier , William Vainchenker Frontiers in Endocrinology, 2017, 8, pp.235. ⟨10.3389/fendo.2017.00235⟩ Journal articles hal-01617931v1
	Ph− myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status Nuria Socoro-Yuste , Marie-Claire Dagher , Anne Gonzalez de Peredo , Julie Mondet , Affif Zaccaria Biochimica et Biophysica Acta - Molecular Cell Research, 2016, 1863 (11), pp.2758 - 2765. ⟨10.1016/j.bbamcr.2016.08.012⟩ Journal articles hal-01400202v1
	CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress Yanyan Zhang , Mallorie Dépond , Liang He , Adlen Foudi , Edward Owusu Kwarteng Scientific Reports, 2016, 6, pp.37827. ⟨10.1038/srep37827⟩ Journal articles inserm-01472381v1
	P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis. Emna Mahfoudhi , Larissa Lordier , Caroline Marty , Jiajia Pan , Anita Roy Oncotarget, 2016, 7, pp.31980-92. ⟨10.18632/oncotarget.7881⟩ Journal articles pasteur-01467563v1
	TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis Emna Mahfoudhi , Ibtissam A Talhaoui , Xenia Cabagnols , Véronique Della Valle , Lise Secardin DNA Repair, 2016, 43, pp.78 - 88. ⟨10.1016/j.dnarep.2016.05.031⟩ Journal articles pasteur-01405648v1
	Presence of atypical thrombopoietin receptor (MPL) mutations in triple negative essential thrombocythemia patients. Xénia Cabagnols , Fabrizia Favale , Florence Pasquier , Kahia Messaoudi , Jean Philippe Defour Blood, 2015, 127, pp.333-342. ⟨10.1182/blood-2015-07-661983⟩ Journal articles hal-01258942v1
	Propriétés et rôles biologiques des protéines TET au cours du développement et de l’hématopoïèse Emna Mahfoudhi , Lise Secardin , Laurianne Scourzic , Olivier Bernard , William Vainchenker Médecine/Sciences, 2015, 31 (3), pp.268-274. ⟨10.1051/medsci/20153103012⟩ Journal articles pasteur-02015397v1
	Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia Iléana Antony-Debré , Vladimir T Manchev , Nathalie Balayn , Dominique Bluteau , Cécile Tomowiak Blood, 2015, 6 (125), pp.930-940. ⟨10.1182/blood-2014-06-585513⟩ Journal articles hal-01681166v1
	DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation Céline Lafaye , Ewa Barbier , Audrey Miscioscia , Christine Saint-Pierre , Alexandra Kraut Biochemical and Biophysical Research Communications, 2014, 446 (1), pp.341-346 Journal articles hal-01994537v1
	Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors Elodie Pronier , Carole Almire , Hayat Mokrani , Aparna Vasanthakumar , Audrey Simon Blood, 2011, 118 (9), pp.2551-2555. ⟨10.1182/blood-2010-12-324707⟩ Journal articles hal-03390385v1
	AKT1 represses gene conversion induced by different genotoxic stresses and induces supernumerary centrosomes and aneuploidy, in hamster ovary cells Isabelle Plo , Bernard S Lopez Oncogene, 2009, 28, pp.2231-2237. ⟨10.1038/onc.2009.85⟩ Journal articles hal-00413792v1
	Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms. Cécile Saint-Martin , Gwendoline Leroy , François Delhommeau , Gérard Panelatti , Sabrina Dupont Blood, 2009, 114 (8), pp.1628-32. ⟨10.1182/blood-2009-01-197525⟩ Journal articles hal-00453231v1
	Defect in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends. Josée Guirouilh-Barbat , Bernard Lopez , Pascale Bertrand , Emilie Rass , Isabelle Plo Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (52), pp.20902-20907 Journal articles hal-00309956v1
	Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals Olivier Sordet , Qasim Khan , Isabelle Plo , Philippe Pourquier , Yoshimasa Urasaki Journal of Biological Chemistry, 2004, 279 (48), pp.50499-50504. ⟨10.1074/jbc.M410277200⟩ Journal articles inserm-02438646v1
	Protein kinase Cζ mediated Raf-1/extracellular-regulated kinase activation by daunorubicin Véronique Mansat-De Mas , Hélène Hernandez , Isabelle Plo , Christine Bezombes , Nicolas Maestre Blood, 2003, 101 (4), pp.1543-1550. ⟨10.1182/blood-2002-05-1585⟩ Journal articles hal-02349095v1
	Oxidative stress-induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C Christine Bezombes , Isabelle Plo , Véronique Mansat-de Mas , Anne Quillet-Mary , Anne Nègre-Salvayre FASEB Journal, 2001, 15 (9), pp.1583-1585. ⟨10.1096/fj.00-0787fje⟩ Journal articles hal-02349143v1
	Daunorubicin- and Mitoxantrone-Triggered Phosphatidylcholine Hydrolysis: Implication in Drug-Induced Ceramide Generation and Apoptosis Ali Bettaieb , Isabelle Plo , Véronique Mansat-de Mas , Anne Quillet-Mary , Thierry Levade Molecular Pharmacology, 1999, 55 (1), pp.118-125. ⟨10.1124/mol.55.1.118⟩ Journal articles hal-02349169v1

	Lyl-1 marks and regulates primitive macrophages and microglia development Shoutang Wang , Deshan Ren , Anna-Lila Kaushik , Gabriel Matherat , Yann Lécluse 2020 Preprints, Working Papers, ... hal-02992875v1
	Predicting the Long-Term Efficacy of Ifnα in JAK2V617F and Calr-Mutated MPN Patients Amandine Tisserand , Robert Noble , Matthieu Mosca , Christophe Marzac , Gaelle Vertenoeil 2020 Preprints, Working Papers, ... hal-03027766v1

Isabelle PLO

Publications

Deregulation of the p19/CDK4/CDK6 axis in Jak2V617F megakaryocytes accelerates the development of myelofibrosis

The double-edged sword of adenosine

Optimizing IFN Alpha Therapy against Myeloproliferative Neoplasms

When monoclonal gammopathy‐associated chronic neutrophilic leukemia is a reactive process distinct from a clonal myeloproliferative neoplasm: Lessons from mistakes

Targeting PP2A-dependent autophagy enhances sensitivity to ruxolitinib in JAK2V617F myeloproliferative neoplasms

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice

Altered Ca2+ Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis

Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model

Modélisation mathématique de l'hématopoïèse et des hémopathies : développement, dynamique et traitement

Inferring the initiation and development of myeloproliferative neoplasms

An inherited gain‐of‐function risk allele in EPOR predisposes to familial JAK2 V617F myeloproliferative neoplasms

Dual role of EZH2 in megakaryocyte differentiation

Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms

Inferring the dynamic of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms

Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms

Identification of biallelic germline variants of SRP68 in a sporadic case with severe congenital neutropenia

Germline ATG2B/GSKIP-containing 14q32 duplication predisposes to early clonal hematopoiesis leading to myeloid neoplasms

HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity

PPARγ agonists promote the resolution of myelofibrosis in preclinical models

IFN: Jekyll and Hyde

CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag

Lyl-1 regulates primitive macrophages and microglia development

Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms

TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells

Induced pluripotent stem cells and hematological malignancies: A powerful tool for disease modeling and drug development

Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN

Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients with myeloproliferative neoplasms

JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML

Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms

Surface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosis

Germline genetic factors in the pathogenesis of myeloproliferative neoplasms

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells

MCM8-and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53- Dependent Myeloid Tumors

Not just another kinase mutation!

Inherited transmission of the CSF3R T618I mutational hotspot in familial chronic neutrophilic leukemia

Impact of interferon on a triple positive polycythemia vera

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells

Disrupted filamin A/αIIbβ3 interaction induces macrothrombocytopenia by increasing RhoA activity

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells

Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond–like syndrome

Specific and Synergistic Targeting of JAK2V617F Cells By Interferon Alpha and Arsenic

Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond–like syndrome

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis

A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma

Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect

CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner

Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0

Identification of MPL R102P Mutation in Hereditary Thrombocytosis

Ph− myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status

CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress

P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis

Presence of atypical thrombopoietin receptor (MPL) mutations in triple negative essential thrombocythemia patients.

Propriétés et rôles biologiques des protéines TET au cours du développement et de l’hématopoïèse

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

AKT1 represses gene conversion induced by different genotoxic stresses and induces supernumerary centrosomes and aneuploidy, in hamster ovary cells

Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms.

Defect in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends.

Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals

Protein kinase Cζ mediated Raf-1/extracellular-regulated kinase activation by daunorubicin

Oxidative stress-induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C

Daunorubicin- and Mitoxantrone-Triggered Phosphatidylcholine Hydrolysis: Implication in Drug-Induced Ceramide Generation and Apoptosis

Lyl-1 marks and regulates primitive macrophages and microglia development

Predicting the Long-Term Efficacy of Ifnα in JAK2V617F and Calr-Mutated MPN Patients