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Isabelle PLO

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Publications

Deregulation of the p19/CDK4/CDK6 axis in Jak2V617F megakaryocytes accelerates the development of myelofibrosis

Hélène Duparc , Delphine Muller , Laure Gilles , Agathe Chédeville , Mira El Khoury
Article dans une revue hal-04471457v1

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Christian Pecquet , Nicolas Papadopoulos , Thomas Balligand , Ilyas Chachoua , Amandine Tisserand
Blood, 2023, 141 (8), pp.917-929. ⟨10.1182/blood.2022016846⟩
Article dans une revue hal-04429999v1

SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice

Christophe Willekens , Lucie Laplane , Tracy Dagher , Camelia Benlabiod , Nicolas Papadopoulos
Leukemia, 2023, 37 (6), pp.1287-1297. ⟨10.1038/s41375-023-01878-0⟩
Article dans une revue hal-04430024v1

When monoclonal gammopathy‐associated chronic neutrophilic leukemia is a reactive process distinct from a clonal myeloproliferative neoplasm: Lessons from mistakes

Christophe Willekens , Claude Chahine , Matteo Dragani , Sabine Khalife-Hachem , Camille Bigenwald
eJHaem, 2023, 4 (3), pp.823-826. ⟨10.1002/jha2.713⟩
Article dans une revue hal-04441619v1
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Optimizing IFN Alpha Therapy against Myeloproliferative Neoplasms

Gurvan Hermange , Paul-Henry Cournède , Isabelle Plo
Journal of Pharmacology and Experimental Therapeutics, 2023, 387 (1), pp.31-43. ⟨10.1124/jpet.122.001561⟩
Article dans une revue hal-04308358v1

Targeting PP2A-dependent autophagy enhances sensitivity to ruxolitinib in JAK2V617F myeloproliferative neoplasms

Charly Courdy , Loïc Platteeuw , Charlotte Ducau , Isabelle de Araujo , Emeline Boet
Blood Cancer Journal, 2023, 13 (1), pp.106. ⟨10.1038/s41408-023-00875-x⟩
Article dans une revue hal-04430069v1
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The double-edged sword of adenosine

Isabelle Plo , Iléana Antony-Debré
Article dans une revue hal-04427016v1
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Inferring the initiation and development of myeloproliferative neoplasms

Gurvan Hermange , Alicia Rakotonirainy , Mahmoud Bentriou , Amandine Tisserand , Mira El-Khoury
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (37), ⟨10.1073/pnas.2120374119⟩
Article dans une revue hal-03844872v1

An inherited gain‐of‐function risk allele in EPOR predisposes to familial JAK2 V617F myeloproliferative neoplasms

Graciela Rabadan Moraes , Florence Pasquier , Christophe Marzac , Eric Deconinck , Carlotta Caterina Damanti
British Journal of Haematology, 2022, ⟨10.1111/bjh.18165⟩
Article dans une revue hal-03638075v1
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Modélisation mathématique de l'hématopoïèse et des hémopathies : développement, dynamique et traitement

Gurvan Hermange , Paul-Henry P.-H. Cournède , Isabelle Plo
Hématologie, 2022, 28 (4), pp.183-200. ⟨10.1684/hma.2022.1762⟩
Article dans une revue hal-04134893v1
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Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model

Brahim Arkoun , Elie Robert , Fabien Boudia , Stefania Mazzi , Virginie Dufour
The Journal of clinical investigation, 2022, 132 (14), pp.131-136. ⟨10.1172/JCI156290⟩
Article dans une revue hal-04441606v1
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Altered Ca2+ Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis

Ralfs Buks , Tracy Dagher , Maria Giustin Rotordam , David Monedero Alonso , Sylvie Cochet
Cells, 2022, 11 (1), pp.49. ⟨10.3390/cells11010049⟩
Article dans une revue hal-03523607v1

CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag

Francesca Basso-Valentina , Gabriel Levy , Leila Varghese , Myriam Oufadem , Benedicte Neven
Blood, 2021, 138 (6), pp.480-485. ⟨10.1182/blood.2020010567⟩
Article dans une revue hal-04429984v1

Lyl-1 regulates primitive macrophages and microglia development

Shoutang Wang , Deshan Ren , Brahim Arkoun , Anna-Lila Kaushik , Gabriel Matherat
Communications Biology, 2021, 4 (1), pp.1382. ⟨10.1038/s42003-021-02886-5⟩
Article dans une revue hal-04441591v1
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HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity

Tamar Tak , Giulio Prevedello , Gaël Simon , Noémie Paillon , Camélia Benlabiod
eLife, 2021, 10, ⟨10.7554/elife.60624⟩
Article dans une revue hal-03266494v2

IFN: Jekyll and Hyde

Isabelle Plo , William Vainchenker
Blood, 2021, 137 (3), pp.291-293. ⟨10.1182/blood.2020008560⟩
Article dans une revue hal-04441320v1

PPARγ agonists promote the resolution of myelofibrosis in preclinical models

Juliette Lambert , Joseph Saliba , Carolina Calderon , Karine Sii-Felice , Mohammad Salma
The Journal of clinical investigation, 2021, 131 (11), ⟨10.1172/JCI136713⟩
Article dans une revue hal-04429976v1

Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms

Lise Secardin , Cintia Gomez Limia , Suzana da Silva-Benedito , Larissa Lordier , Mira El-Khoury
HemaSphere, 2021, 5 (7), pp.e593. ⟨10.1097/HS9.0000000000000593⟩
Article dans une revue hal-04429987v1
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Dual role of EZH2 in megakaryocyte differentiation

Stefania Mazzi , Philippe Dessen , Mathieu Vieira , Virginie Dufour , Marie Cambot
Blood, 2021, 138 (17), pp.1603-1614. ⟨10.1182/blood.2019004638⟩
Article dans une revue hal-03448744v1
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Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms

Lise Secardin , Cintia Gomez Limia , Suzana da Silva-Benedito , Larissa Lordier , Mira El-Khoury
HemaSphere, 2021, 5 (7), pp.e593. ⟨10.1097/HS9.0000000000000593⟩
Article dans une revue hal-03263690v1

Germline ATG2B/GSKIP-containing 14q32 duplication predisposes to early clonal hematopoiesis leading to myeloid neoplasms

Jean Pegliasco , Pierre Hirsch , Christophe Marzac , Françoise Isnard , Jean-Côme Meniane
Leukemia, 2021, 36 (1), pp.126-137. ⟨10.1038/s41375-021-01319-w⟩
Article dans une revue hal-04441339v1
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Identification of biallelic germline variants of SRP68 in a sporadic case with severe congenital neutropenia

Barbara Schmaltz-Panneau , Anne Pagnier , Séverine Clauin , Julien Buratti , Caroline Marty
Haematologica, 2021, 106 (4), pp.1216-1219. ⟨10.3324/haematol.2020.247825⟩
Article dans une revue hal-03243114v1
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Inferring the dynamic of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms

Matthieu Mosca , Gurvan Hermange , Amandine Tisserand , Robert John Noble , Christophe Marzac
Article dans une revue hal-03452002v1
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Germline genetic factors in the pathogenesis of myeloproliferative neoplasms

Christine Bellanné-Chantelot , Graciela Rabadan Moraes , Barbara Schmaltz-Panneau , Caroline Marty , William Vainchenker
Blood Reviews, 2020, 42, pp.100710 -. ⟨10.1016/j.blre.2020.100710⟩
Article dans une revue hal-03491411v1

Surface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosis

Oliver Kepp , Peng Liu , Liwei Zhao , Isabelle Plo , Guido Kroemer
OncoImmunology, 2020, 9 (1), pp.5323-5337. ⟨10.1080/2162402X.2020.1792037⟩
Article dans une revue hal-04441316v1

Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms

Mira El-Khoury , Xénia Cabagnols , Matthieu Mosca , Gaëlle Vertenoeil , Christophe Marzac
Oncogene, 2020, 39 (31), pp.5323-5337. ⟨10.1038/s41388-020-1368-3⟩
Article dans une revue hal-04438597v1
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JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML

Tracy Dagher , Nabih Maslah , Valérie Edmond , Bruno Cassinat , William Vainchenker
Journal of Experimental Medicine, 2020, 218, ⟨10.1084/jem.20201268⟩
Article dans une revue hal-04055414v1

TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells

Lise Secardin , Cintia Elisabeth Gomez Limia , Antonio Di Stefano , Martin Hernan Bonamino , Joseph Saliba
Stem Cell Research, 2020, 44, pp.101755. ⟨10.1016/j.scr.2020.101755⟩
Article dans une revue hal-04429959v1

Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms

Mira El-Khoury , Xénia Cabagnols , Matthieu Mosca , Gaëlle Vertenoeil , Christophe Marzac
Oncogene, 2020, 39 (31), pp.5323-5337. ⟨10.1038/s41388-020-1368-3⟩
Article dans une revue hal-04429967v1

Induced pluripotent stem cells and hematological malignancies: A powerful tool for disease modeling and drug development

A. Donada , F. Basso-Valentina , B. Arkoun , B. Monte-Mor , Isabelle Plo
Stem Cell Research, 2020, 49 (2), pp.102060. ⟨10.1016/j.scr.2020.102060⟩
Article dans une revue hal-04441319v1

Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients with myeloproliferative neoplasms

Christian Di Buduo , Vittorio Abbonante , Caroline Marty , Francesco Moccia , Elisa Rumi
Blood, 2020, 135 (2), pp.133-144. ⟨10.1182/blood.2019001103⟩
Article dans une revue hal-04430037v1

Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN

Camélia Benlabiod , Maira da Costa Cacemiro , Audrey Nédélec , Valérie Edmond , Delphine Muller
Nature Communications, 2020, 11 (1), pp.4886. ⟨10.1038/s41467-020-18691-3⟩
Article dans une revue hal-04429972v1

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells

Olivier Mansier , Badr Kilani , Amelie V Guitart , Alexandre Guy , Virginie Gourdou-Latyszenok
Blood, 2019, 134 (26), pp.2383-2387. ⟨10.1182/blood.2019001163⟩
Article dans une revue hal-04140431v1

Disrupted filamin A/αIIbβ3 interaction induces macrothrombocytopenia by increasing RhoA activity

Alessandro Donada , Nathalie Balayn , Dominika Sliwa , Larissa Lordier , Valentina Ceglia
Blood, 2019, 133 (16), pp.1778-1788. ⟨10.1182/blood-2018-07-861427⟩
Article dans une revue hal-04441275v1

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells

Olivier Mansier , Badr Kilani , Amélie Guitart , Alexandre Guy , Virginie Gourdou-Latyszenok
Blood, 2019, 134 (26), pp.2383-2387. ⟨10.1182/blood.2019001163⟩
Article dans une revue hal-04429945v1

Impact of interferon on a triple positive polycythemia vera

Hugo Campario , Matthieu Mosca , Bernard Aral , Valentin Bourgeois , Pauline Martin
Leukemia, 2019, 34 (4), pp.1210-1212. ⟨10.1038/s41375-019-0636-0⟩
Article dans une revue hal-04441302v1

Not just another kinase mutation!

Isabelle Plo , Caroline Marty
Blood, 2019, 134 (26), pp.2335-2337. ⟨10.1182/blood.2019003650⟩
Article dans une revue hal-04430049v1

Inherited transmission of the CSF3R T618I mutational hotspot in familial chronic neutrophilic leukemia

Nicolas Duployez , Christophe Willekens , Isabelle Plo , Alice Marceau-Renaut , Stéphane de Botton
Blood, 2019, 134 (26), pp.2414-2416. ⟨10.1182/blood.2019003206⟩
Article dans une revue hal-04441297v1

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells

Olivier Mansier , Badr Kilani , Amélie V. Guitart , Alexandre Guy , Virginie Gourdou-Latyszenok
Blood, 2019, 134 (26), pp.2383-2387. ⟨10.1182/blood.2019001163⟩
Article dans une revue hal-03194452v1
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MCM8-and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53- Dependent Myeloid Tumors

Malik Lutzmann , Florence F. Bernex , Cindy da Costa de Jesus , Dana Hodroj , Caroline Marty
Cell Reports, 2019, 28 (11), pp.2851 - 2865. ⟨10.1016/j.celrep.2019.07.095⟩
Article dans une revue hal-02397140v1
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HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

Margaux Sevin , Lucia Kubovcakova , Nicolas Pernet , Sebastien Causse , Franck Vitte
Nature Communications, 2018, 9 (1), pp.1431. ⟨10.1038/s41467-018-03627-9⟩
Article dans une revue hal-01864299v1

Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond–like syndrome

Christine Bellanné-Chantelot , Barbara Schmaltz-Panneau , Caroline Marty , Odile Fenneteau , Isabelle Callebaut
Blood, 2018, 132 (12), pp.1318-1331. ⟨10.1182/blood-2017-12-820308⟩
Article dans une revue hal-02343565v1

Specific and Synergistic Targeting of JAK2V617F Cells By Interferon Alpha and Arsenic

Tracy Dagher , Valérie Edmond , Bruno Cassinat , Valérie Lallemand-Breitenbach , Emmanuelle Verger
Blood, 2018, 132 (Supplement 1), pp.52-52. ⟨10.1182/blood-2018-99-112518⟩
Article dans une revue hal-04055417v1

Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond–like syndrome

Christine Bellanné-Chantelot , Barbara Schmaltz-Panneau , Caroline Marty , Odile Fenneteau , Isabelle Callebaut
Blood, 2018, 132 (12), pp.1318-1331. ⟨10.1182/blood-2017-12-820308⟩
Article dans une revue hal-04429910v1
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Identification of MPL R102P Mutation in Hereditary Thrombocytosis

Christine Bellanne-Chantelot , Matthieu Mosca , Caroline Marty , Rémi Favier , William Vainchenker
Frontiers in Endocrinology, 2017, 8, pp.235. ⟨10.3389/fendo.2017.00235⟩
Article dans une revue hal-01617931v1
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Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0

Vladimir T. Manchev , Hind Bouzid , Iléana Antony-Debré , Betty Leite , Guillaume Meurice
Journal of Cellular and Molecular Medicine, 2017, 21 (6), pp.1237 - 1242. ⟨10.1111/jcmm.13051⟩
Article dans une revue hal-01537098v1
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CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner

Hadjer Abdelouahab , Yanyan Zhang , Monika Wittner , Shinya Oishi , Nobutaka Fujii
Oncotarget, 2017, 8 (33), ⟨10.18632/oncotarget.10789⟩
Article dans une revue hal-02380531v1
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Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect

Isabelle Godin , Kahia Messaoudi , Ashfaq Ali , Rameez Ishaq , Alberta Palazzo
Nature Communications, 2017, 8, ⟨10.1038/s41467-017-01690-2⟩
Article dans une revue hal-02992921v1
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A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma

Elias A El-Habr , Gustavo Luiz Dubois , Fanny Burel-Vandenbos , Alexandra Bogeas , Joanna Lipecka
Acta Neuropathologica, 2017, 133 (4), pp.645-660. ⟨10.1007/s00401-016-1659-5⟩
Article dans une revue inserm-01481051v1
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New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis

Florence Pasquier , Caroline Marty , Thomas Balligrand , Frédérique Verdier , Sarah Grosjean
Article dans une revue hal-02403399v1
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TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis

Emna Mahfoudhi , Ibtissam A Talhaoui , Xenia Cabagnols , Véronique Della Valle , Lise Secardin
DNA Repair, 2016, 43, pp.78 - 88. ⟨10.1016/j.dnarep.2016.05.031⟩
Article dans une revue pasteur-01405648v1

Ph− myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status

Nuria Socoro-Yuste , Marie-Claire Dagher , Anne Gonzalez de Peredo , Julie Mondet , Affif Zaccaria
Biochimica et Biophysica Acta - Molecular Cell Research, 2016, 1863 (11), pp.2758 - 2765. ⟨10.1016/j.bbamcr.2016.08.012⟩
Article dans une revue hal-01400202v1
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CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress

Yanyan Zhang , Mallorie Dépond , Liang He , Adlen Foudi , Edward Owusu Kwarteng
Scientific Reports, 2016, 6, pp.37827. ⟨10.1038/srep37827⟩
Article dans une revue inserm-01472381v1
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P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.

Emna Mahfoudhi , Larissa Lordier , Caroline Marty , Jiajia Pan , Anita Roy
Oncotarget, 2016, 7, pp.31980-92. ⟨10.18632/oncotarget.7881⟩
Article dans une revue pasteur-01467563v1

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

Iléana Antony-Debré , Vladimir T Manchev , Nathalie Balayn , Dominique Bluteau , Cécile Tomowiak
Blood, 2015, 125, pp.930-940. ⟨10.1182/blood-2014-06-585513⟩
Article dans une revue hal-01681166v1
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Propriétés et rôles biologiques des protéines TET au cours du développement et de l’hématopoïèse

Emna Mahfoudhi , Lise Secardin , Laurianne Scourzic , Olivier Bernard , William Vainchenker
Médecine/Sciences, 2015, 31 (3), pp.268-274. ⟨10.1051/medsci/20153103012⟩
Article dans une revue pasteur-02015397v1

Presence of atypical thrombopoietin receptor (MPL) mutations in triple negative essential thrombocythemia patients.

Xénia Cabagnols , Fabrizia Favale , Florence Pasquier , Kahia Messaoudi , Jean Philippe Defour
Blood, 2015, 127, pp.333-342. ⟨10.1182/blood-2015-07-661983⟩
Article dans une revue hal-01258942v1

DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation

Céline Lafaye , Ewa Barbier , Audrey Miscioscia , Christine Saint-Pierre , Alexandra Kraut
Biochemical and Biophysical Research Communications, 2014, 446 (1), pp.341-346
Article dans une revue hal-01994537v1

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

Elodie Pronier , Carole Almire , Hayat Mokrani , Aparna Vasanthakumar , Audrey Simon
Blood, 2011, 118 (9), pp.2551-2555. ⟨10.1182/blood-2010-12-324707⟩
Article dans une revue hal-03390385v1

Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms.

Cécile Saint-Martin , Gwendoline Leroy , François Delhommeau , Gérard Panelatti , Sabrina Dupont
Blood, 2009, 114 (8), pp.1628-32. ⟨10.1182/blood-2009-01-197525⟩
Article dans une revue hal-00453231v1

AKT1 represses gene conversion induced by different genotoxic stresses and induces supernumerary centrosomes and aneuploidy, in hamster ovary cells

Isabelle Plo , Bernard S Lopez
Oncogene, 2009, 28, pp.2231-2237. ⟨10.1038/onc.2009.85⟩
Article dans une revue hal-00413792v1

Defect in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends.

Josée Guirouilh-Barbat , Bernard Lopez , Pascale Bertrand , Emilie Rass , Isabelle Plo
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (52), pp.20902-20907
Article dans une revue hal-00309956v1

Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals

Olivier Sordet , Qasim Khan , Isabelle Plo , Philippe Pourquier , Yoshimasa Urasaki
Journal of Biological Chemistry, 2004, 279 (48), pp.50499-50504. ⟨10.1074/jbc.M410277200⟩
Article dans une revue inserm-02438646v1

Protein kinase Cζ mediated Raf-1/extracellular-regulated kinase activation by daunorubicin

Véronique Mansat-De Mas , Hélène Hernandez , Isabelle Plo , Christine Bezombes , Nicolas Maestre
Blood, 2003, 101 (4), pp.1543-1550. ⟨10.1182/blood-2002-05-1585⟩
Article dans une revue hal-02349095v1

Oxidative stress-induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C

Christine Bezombes , Isabelle Plo , Véronique Mansat-de Mas , Anne Quillet-Mary , Anne Nègre-Salvayre
FASEB Journal, 2001, 15 (9), pp.1583-1585. ⟨10.1096/fj.00-0787fje⟩
Article dans une revue hal-02349143v1

Daunorubicin- and Mitoxantrone-Triggered Phosphatidylcholine Hydrolysis: Implication in Drug-Induced Ceramide Generation and Apoptosis

Ali Bettaieb , Isabelle Plo , Véronique Mansat-de Mas , Anne Quillet-Mary , Thierry Levade
Molecular Pharmacology, 1999, 55 (1), pp.118-125. ⟨10.1124/mol.55.1.118⟩
Article dans une revue hal-02349169v1