Isabelle SEGALAS-MILAZZO

Publications

Article dans une revue (22)

Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease Anne Rovelet-Lecrux,Sebastien Feuillette,Laetitia Miguel,Catherine Schramm,Ségolène Pernetet al. Acta Neuropathologica Communications, 2021, 9, ⟨10.1186/s40478-021-01294-4⟩ Article dans une revue hal-03512083v1
Characterization of β-turns by electronic circular dichroism spectroscopy: A coupled molecular dynamics and time-dependent density functional theory computational study Mattia Migliore,Andrea Bonvicini,Vincent Tognetti,Laure Guilhaudis,Marc Baadenet al. Physical Chemistry Chemical Physics, 2020, 22 (3), pp.1611-1623. ⟨10.1039/C9CP05776E⟩ Article dans une revue hal-02397135v1
Biochemical and biophysical combined study of bicarinalin, an ant venom antimicrobial peptide Nathan Téné,Elsa Bonnafé,Fanny Berger,Aline Rifflet,Laure Guilhaudiset al. Peptides, 2016, 79, pp.103-113. ⟨10.1016/j.peptides.2016.04.001⟩ Article dans une revue istex hal-01974252v1
Lethal Neonatal Progression of Fetal Cardiomegaly Associated to ACAD9 Deficiency Jennifer Lagoutte-Renosi,Isabelle Ségalas-Milazzo,Marie Crahes,Florian Renosi,Laurence Menu-Bouaouicheet al. Journal of Inherited Metabolic Disease, 2016, 28, pp.1-10. ⟨10.1007/8904_2015_499⟩ Article dans une revue hal-02046219v1
Determination of Multimodal Isotopic Distributions: The Case of a (15)N Labeled Protein Produced into Hairy Roots. Romain Trouillard,Marie Hubert-Roux,Vincent Tognetti,Laure Guilhaudis,Carole Plassonet al. Analytical Chemistry, 2015, 87 (12), pp.5938-5946. ⟨10.1021/acs.analchem.5b01558⟩ Article dans une revue hal-01186525v1
Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies Cindy Neveu,Fabienne Dulin,Benjamin Lefranc,Ludovic Galas,Colas Calbrixet al. British Journal of Pharmacology, 2014, 171 (19), pp.4425-4439. ⟨10.1111/bph.12808⟩ Article dans une revue hal-01973604v1
Fluorinated pseudopeptide analogues of the neuropeptide 26RFa: synthesis, biological, and structural studies. Camille Pierry,Samuel Couve-Bonnaire,Laure Guilhaudis,Cindy Neveu,Amélie Marotteet al. ChemBioChem, 2013, 14 (13), pp.1620-1633. ⟨10.1002/cbic.201300325⟩ Article dans une revue istex hal-01939216v1
Rational design of a low molecular weight, stable, potent, and long-lasting GPR103 aza-β3-pseudopeptide agonist Cindy Neveu,Benjamin Lefranc,Olivier Tasseau,Jean-Claude Do-Rego,Adèle Bourmaudet al. Journal of Medicinal Chemistry, 2012, 55 (17), pp.7516-7524. ⟨10.1021/jm300507d⟩ Article dans une revue hal-01939210v1
Solution structure of the region 51-160 of human KIN17 reveals an atypical winged helix domain Ludovic Carlier,Joël Couprie,Albane Le Maire,Laure Guilhaudis,Isabelle Milazzo-Segalaset al. Protein Science, 2009, 16 (12), pp.2750 - 2755 Article dans une revue hal-00425483v1
Molecular and conformational determinants of pituitary adenylate cyclase-activating polypeptide (PACAP) for activation of the PAC1 receptor. Steve Bourgault,David Vaudry,Isabelle Ségalas-Milazzo,Laure Guilhaudis,Alain Couvineauet al. Journal of Medicinal Chemistry, 2009, 52 (10), pp.3308-3316. ⟨10.1021/jm900291j⟩ Article dans une revue pasteur-00819957v1
In Vivo and in Vitro Structure-Activity Relationships and Structural Conformation of Kisspeptin-10-Related Peptides Ester Gutiérrez-Pascual,Jérôme Leprince,Antonio Martínez-Fuentes,Isabelle Ségalas-Milazzo,Rafael Pinedaet al. Molecular Pharmacology, 2009, 76 (1), pp.58-67. ⟨10.1124/mol.108.053751⟩ Article dans une revue hal-01962751v1
Structure–activity relationships of urotensin II and URP Jérôme Leprince,David Chatenet,Christophe Dubessy,Alain Fournier,Bruno Pfeifferet al. Peptides, 2008, 29 (5), pp.658-673. ⟨10.1016/j.peptides.2007.08.014⟩ Article dans une revue istex hal-01972605v1
Solution structure of urotensin-II receptor extracellular loop III and characterization of its interaction with urotensin-II Stéphane Boivin,Isabelle Ségalas-Milazzo,Laure Guilhaudis,Hassan Oulyadi,Alain Fournieret al. Peptides, 2008, 29 (5), pp.700-710. ⟨10.1016/j.peptides.2008.02.024⟩ Article dans une revue istex hal-02352152v1
Biological and structural analysis of truncated analogs of PACAP27. Steve Bourgault,David Vaudry,Laure Guilhaudis,Emilie Raoult,Alain Couvineauet al. Journal of Molecular Neuroscience, 2008, 36 (1-3), pp.260-269. ⟨10.1007/s12031-008-9081-7⟩ Article dans une revue istex pasteur-00819989v1
Structure and functions of the novel hypothalamic RFamide neuropeptides R-RFa and 26RFa in vertebrates Nicolas Chartrel,Federica Bruzzone,Jérôme Leprince,Hélène Tollemer,Youssef Anouaret al. Peptides, 2006, 27 (5), pp.1110-1120. ⟨10.1016/j.peptides.2005.06.035⟩ Article dans une revue istex hal-01960808v1
Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging. Séverine Zirah,Sergey A Kozin,Alexey K Mazur,Alain Blond,Michel Cheminantet al. Journal of Biological Chemistry, 2006, 281 (4), pp.2151-61. ⟨10.1074/jbc.M504454200⟩ Article dans une revue hal-00145835v1
Characterization of urotensin-II receptor structural domains involved in the recognition of U-II, URP, and urantide. Stéphane Boivin,Laure Guilhaudis,Isabelle Milazzo,Hassan Oulyadi,Daniel Davoustet al. Biochemistry, 2006, 45 (19), pp.5993-6002. ⟨10.1021/bi060190b⟩ Article dans une revue istex pasteur-00820020v1
NMR Assignment of Region 51–160 of Human KIN17, a DNA and RNA-binding Protein Ludovic Carlier,Albane Le Maire,Sandrine Braud,Cédric Masson,Muriel Gondryet al. Journal of Biomolecular NMR, 2006, 36 (S1), pp.29. ⟨10.1007/s10858-006-0013-y⟩ Article dans une revue istex hal-02352045v1
Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity Romain Thuau,Laure Guilhaudis,Isabelle Ségalas-Milazzo,Nicolas Chartrel,Hassan Oulyadiet al. Peptides, 2005, 26 (5), pp.779-789. ⟨10.1016/j.peptides.2005.01.006⟩ Article dans une revue istex hal-01974257v1
Structure–activity relationships and structural conformation of a novel urotensin II-related peptide David Chatenet,Christophe Dubessy,Jérôme Leprince,Cédric Boularan,Ludovic Carlieret al. Peptides, 2004, 25 (10), pp.1819-1830. ⟨10.1016/j.peptides.2004.04.019⟩ Article dans une revue istex hal-01960815v1
Thermolysin-linearized microcin J25 retains the structured core of the native macrocyclic peptide and displays antimicrobial activity. Alain Blond,Michel Cheminant,Delphine Destoumieux-Garzón,Isabelle Ségalas-Milazzo,Jean Peduzziet al. European Journal of Biochemistry, 2002, 269 (24), pp.6212-22 Article dans une revue hal-00013189v1
Solution structure of microcin J25, the single macrocyclic antimicrobial peptide from Escherichia coli. Alain Blond,Michel Cheminant,Isabelle Ségalas-Milazzo,Jean Péduzzi,Michel Barthélémyet al. European Journal of Biochemistry, 2001, 268 (7), pp.2124-2133. ⟨10.1046/j.1432-1327.2001.02090.x⟩ Article dans une revue hal-00086378v1

Communication dans un congrès (18)

Liquid state NMR applied to enzyme/substrate/inhibitor Laure Guilhaudis,Gaël Coadou,Muriel Sebban,Lina Truong,Isabelle Ségalas-Milazzoet al. Polymers for sustainable global development (POLY-CHAR, 2019), May 2019, Katmandou, Nepal Communication dans un congrès hal-02542279v1
New insight in the structural characterization of turns in peptides: determination of NMR discriminatory parameters Mattia Migliore,Laure Guilhaudis,Benjamin Lefranc,Jérôme Leprince,Hassan Oulyadiet al. Naples workshop on bioactive peptides (16, 2018), Jun 2018, Naples, Italy Communication dans un congrès hal-02381233v1
Conformational studies of urotensinergic peptides using NMR and molecular modelling, in DPC micelles Najjar Riham,Laure Guilhaudis,Nicolas Perzo,Hélène Castel,Isabelle Ségalas-Milazzo Congrès du Groupe français des peptides et des protéines (GFPP, 20, 2017), Mar 2017, Arcachon, France Communication dans un congrès hal-02381245v1
Investigating the conformational determinants of the activity of 26RFa: an orexigenic neuropeptide Amélie Marotte,Isabelle Buchet,Laure Guilhaudis,Benjamin Lefranc,Cindy Neveuet al. Naples workshop on bioactive peptides (15, 2016), Jun 2016, Naples, Italy Communication dans un congrès hal-02380461v1
Impact of a key ancestral deletion in chemokine and vasoactive peptide receptors on G protein couplings and chemotaxis Jane Eilen Joubert,Laurence Desrues,Nicolas Perzo,B Taddese,Céline Lecointreet al. GPCRs: Beyond Structure Towards Therapy, Sep 2015, Prato, Italy Communication dans un congrès hal-02296948v1
Production of uniformly 15N/13C labeled glycosylated proteins by hairy roots in view to NMR structural studies Romain Trouillard,Marie Hubert-Roux,Vincent Tognetti,Laure Guilhaudis,Carole Plassonet al. Congrès du Groupe français des peptides et des protéines (GFPP, 19, 2015), May 2015, Port-Bail, France Communication dans un congrès hal-02543922v1
Production of uniformly 15N/13C labeled glycosylated proteins by hairy roots in view to NMR structural studies Romain Trouillard,Marie Hubert-Roux,Vincent Tognetti,Laure Guilhaudis,Carole Plassonet al. Advanced Isotopic Labelling Methods for integrated structural biology (AILM, 2015), Feb 2015, Grenoble, France Communication dans un congrès hal-02378500v1
Production de protéines marquées 15N ou 15N/13C dans un système d’expression racinaire et analyse de l’incorporation du marquage par spectrométrie de masse Romain Trouillard,Marie Hubert,Laure Guilhaudis,Laurence Menu-Bouaouiche,Carole Plassonet al. Journée de l’Institut de recherche et d'innovation biomédicale (3, 2014), Jun 2014, Caugé, France Communication dans un congrès hal-02113295v1
Key proline position in chemokine and vasoactive peptide receptors on chemotaxic behavior Hélène Castel,Jane Eilen Joubert,Céline Lecointre,A Arrichiello,Laurence Desrueset al. International Symposium on Regulatory Peptides (REGPEP, 20, 2014), Sep 2014, Kyoto, Japan Communication dans un congrès hal-02299536v1
Impact of a key mutation of a proline in chemokine and vasoactive peptide receptors: A structural determinant in chemotaxis? Jane Eilen Joubert,Laurence Desrues,Nicolas Perzo,Céline Lecointre,A Arrichielloet al. GDR-GPCR (3, 2014), Oct 2014, Montpellier, France Communication dans un congrès hal-02299458v1
Production dans des plantes transgéniques de protéines marquées 13C et 15N en vue d’une étude structurale par RMN Lucie Dubousset,Abdoul-Salam Koroney,Marie-Christine Kiefer-Meyer,Gaëlle Durambur,Laure Guilhaudiset al. Journée scientifique de l'IFRMP23 (17, 2011), Jun 2011, Rouen, France Communication dans un congrès hal-02121347v1
Etude pharmacochimique du 26RFa : relations structure-activité d'une série d'Aza-B3-pseudopeptides Laure Guilhaudis,Cindy Neveu,Olivier Le Marec,Olivier Tasseau,Benjamin Lefrancet al. 14EME JOURNEE SCIENTIFIQUE DE L'IFRMP23, Jun 2008, EVREUX, France Communication dans un congrès hal-00361308v1
Activité biologique d'une série d'analogues pseudopeptidiques aza-Β3 du 26RFa, le ligand endogène du GPR103 Olivier Le Marec,Cindy Neveu,Olivier Tasseau,Laure Guilhaudis,Isabelle Ségalas-Milazzoet al. 35ème Colloque de la Société de Neuroendocrinologie, Sep 2008, Strasbourg, France Communication dans un congrès hal-00361319v1
Three-Dimensional structure of a thermolysin-linearized microcin J25: Evidence for an essential role of the 11-16 loop in microcin J25 structure and antimicrobial activity A. Blond,M. Cheminant,I. Ségalas-Milazzo,D. Destoumieux-Garzón,C. Goulardet al. Peptides 2002, 2002, France. pp.866-867 Communication dans un congrès hal-00013606v1
Three-Dimensional structure of a thermolysin-linearized microcin J25: Evidence for an essential role of the 11-16 loop in microcin J25 structure and antimicrobial activity A. Blond,M. Cheminant,I. Ségalas-Milazzo,D. Destoumieux-Garzón,C. Goulardet al. 27th European Peptide Symposium, Sep 2002, Sorrento, Italy Communication dans un congrès hal-00013628v1
NMR-Based solution structure of the 14-residue peptaibol, harzianin HC IX I. Segalas,Y. Prigent,D. Davoust,Bernard Bodo,S. Rebuffat 25th European Peptide Symposium, 2000, France. pp.382-383 Communication dans un congrès hal-00087888v1
The NMR three-dimensional structure of the peptaibol antibiotic longibrachin LGA I G. Leclerc,M. Cheminant,I. Segalas,A. Blond,J. Peduzziet al. Peptides 2000, Proceedings 26th European Peptide Symposium, Sep 2000, Montpellier, France Communication dans un congrès hal-00087884v1
The compact three-dimensional structure of the 21-residue cyclic antibiotic peptide, microcin J25 Alain Blond,M. Cheminant,Isabelle Ségalas-Milazzo,Jean Peduzzi,M. Barthélémyet al. Peptides 2000, Proceedings 26h European Peptide Symposium, 2000, Montpellier, France Communication dans un congrès hal-00087869v1

Poster de conférence (18)

Characterization of beta-turns by ECD spectroscopy. A coupled molecular dynamics and TD-DFT computational study Andrea Bonvicini,Mattia Migliore,Isabelle Ségalas-Milazzo,Vincent Tognetti,Laurent Joubertet al. Conference on Chiroptical Spectroscopy - CD 2019 (17, 2019), Jun 2019, Pise, Italy Poster de conférence hal-02542310v1
New insights in structural characterization of turns in peptides: in silico determination of new NMR discriminatory parameters Mattia Migliore,Laure Guilhaudis,Benjamin Lefranc,Jérôme Leprince,Hassan Oulyadiet al. Journée de l’Ecole doctorale normande de chimie (JEDNC, 2019), Jul 2019, Caen, France Poster de conférence hal-02542528v1
Structural characterization of turns in proteins and peptides: new NMR discriminatory parameters by molecular modelling Mattia Migliore,Laure Guilhaudis,Benjamin Lefranc,Jérôme Leprince,Hassan Oulyadiet al. Congrès du Groupe français des peptides et des protéines (GFPP, 21, 2019), May 2019, Amboise, France Poster de conférence hal-02542520v1
Comparative structural analyses of urotensinergic peptides by CD spectroscopy, solution NMR and molecular modelling Riham Najjar,Laure Guilhaudis,Maxime Burnacci,Hassan Oulyadi,Hélène Castelet al. European Magnetic Resonance Meeting (EUROMAR, 14, 2018), Jul 2018, Nantes, France Poster de conférence hal-02452551v1
New insights in structural characterization of turns in peptides: in silico determination of new NMR discriminatory parameters Mattia Migliore,Laure Guilhaudis,Benjamin Lefranc,Jérôme Leprince,Hassan Oulyadiet al. Journée de l’Ecole doctorale normande de chimie (JEDNC, 2018), Jun 2018, Le Havre, France Poster de conférence hal-02542538v1
A structural determinant in TM2 of chemokine and vasoactive peptide GPCRs plays a key role in cell chemotactic migration Laurence Desrues,Eilen Joubert Jane,Pierre-Mickaël Coly,Alexandre Mutel,Nicolas. Perzoet al. Annual Meeting of GDR3545 (6, 2017), Nov 2017, Paris, France Poster de conférence hal-02341487v1
Proline in 2.58 of chemokine and vasoactive peptide G-protein coupled receptors: A structural determinant in chemotaxis? Laurence Desrues,Eilen Joubert Jane,Nicolas Perzo,Laure Guilhaudis,Isabelle Milazzoet al. Annual Meeting of the LARC-Neuroscience network (21, 2017), Oct 2017, Lille, France Poster de conférence hal-02341500v1
Structural characterization of turns in bioactive peptides - Determination of NMR discriminatory parameters Mattia Migliore,Laure Guilhaudis,Benjamin Lefranc,Jérôme Leprince,Isabelle Ségalas-Milazzo Journée de l’Ecole doctorale normande de chimie (JEDNC, 2017), Jun 2017, Mont-Saint-Aignan, France Poster de conférence hal-02542501v1
Structural analyses of urotensinergic peptides by NMR spectroscopy and molecular modelling R. Najjar,Laure Guilhaudis,Nicolas Perzo,Hélène Castel,Isabelle Ségalas-Milazzo Journée normande de recherche biomédicale IRIB-ICORE (1, 2016), Sep 2016, Rouen, France Poster de conférence hal-02345177v1
Impact of a key ancestral deletion in chemokine and vasoactive peptide receptors on chemotaxis Hélène Castel,Jane Eileen Joubert,Laurence Desrues,Nicolas Perzo,Céline Lecointreet al. Colloque de la Société de neuroendocrinologie (41, 2016), Oct 2016, Corte, France Poster de conférence hal-02349071v1
Solution NMR studies of urotensinergic peptides in DPC micelles, a membrane mimetic medium R. Najjar,Laure Guilhaudis,Nicolas Perzo,Hélène Castel,Isabelle Ségalas-Milazzo International Regulatory Peptide Society Congress, Jul 2016, Rouen, France Poster de conférence hal-02345192v1
Demonstration of the occurrence of a non-transmembrane -helix in the extracellular loop 2 of GPR103 Karima Alim,Laure Guilhaudis,Isabelle Ségalas-Milazzo,David Vaudry,Julien Chuquetet al. Congrès du Groupe français des peptides et des protéines (GFPP, 19, 2015), May 2015, Port-Bail, France Poster de conférence hal-02543930v1
Asymmetric synthesis of fluoropseudopeptides towards constrained prolines and analogue of neuropeptide 26 RFa Samuel Couve-Bonnaire,Camille Pierry,Emilie Villiers,Guillaume Dutheuil,Laure Guilhaudiset al. Congrès du Groupe français des peptides et des protéines (GFPP, 19, 2015), May 2015, Port-Bail, France Poster de conférence hal-02543329v1
Impact of a key ancestral deletion in chemokine and vasoactive peptide receptors on chemotaxis Jane Eileen Joubert,Laurence Desrues,Nicolas Perzo,Céline Lecointre,Laure Guilhaudiset al. Colloque de la Société des neurosciences (12, 2015), May 2015, Montpellier, France Poster de conférence hal-02349910v1
Impact of a key mutation of a proline in chemokine and vasoactive peptide receptors: A structural determinant in chemotaxis? Eileen Joubert,Laurence Desrues,Nicolas Perzo,Céline Lecointre,Antoine Arrichielloet al. Journées de l’Ecole doctorale normande Biologie Intégrative, Santé, Environnement (EdN BISE, 18, 2015), Mar 2015, Mont-Saint-Aignan, France Poster de conférence hal-02349914v1
Comparative structural analyses of urotensinergic peptides by CD spectroscopy, NMR and Molecular Modelling Laure Guilhaudis,Riham Najjar,Nicolas Perzo,Hélène Castel,Isabelle Ségalas-Milazzo Congrès du Groupe français des peptides et des protéines (19ème GFPP 2015), May 2015, Port-Bail, France. Poster de conférence hal-02349922v1
Comparative structural analyses of urotensinergic peptides by CD spectroscopy, NMR and Molecular Modelling Riham Najjar,Laure Guilhaudis,Nicolas Perzo,Hélène Castel,Isabelle Ségalas-Milazzo Journée Scientifique de l’Institut de Recherche et d’Innovation Biomédicale (IRIB 2015), Jun 2015, Rouen, France. Poster de conférence hal-02543925v1
Production de protéines marquées 15N ou 15N/13C dans un système d’expression racinaire et analyse de l’incorporation du marquage par spectrométrie de masse Romain Trouillard,Marie Hubert,Laure Guilhaudis,Laurence Menu-Bouaouiche,Carole Plassonet al. Journée de l’Institut de recherche et d’innovation biomédicale (2, 2013), Jun 2013, Rouen, France Poster de conférence hal-02115362v1

Ouvrages (3)

Synthesis and biological activity of a series of aza-b3-pseudopeptides related to 26RFa, the endogenous ligand of GPR103. Peptides 2008, Proceedings of the 30th European Peptide Symposium, pp 524-525 Olivier Le Marec,Cindy Neveu,Olivier Tasseau,Laure Guilhaudis,Isabelle Ségalas-Milazzoet al. 2009 Ouvrages hal-01962817v1
Agonist and antagonist activities of peptides related to 26RFa, the last member of the RFamide peptide superfamily. Peptides 2006, Proceedings of the 29th European Peptide Symposium, pp 378-279 Olivier Le Marec,Christophe Dubessy,Jean-Claude Do Rego,Olivier Nosjean,Valérie Audinotet al. 2007 Ouvrages hal-01962812v1
Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptides 2004. Proceedings of the 3rd International and 28th European Symposium, pp 804-805 David Chatenet,Jérôme Leprince,Christophe Dubessy,Ludovic Carlier,Cedric Boularanet al. 2005 Ouvrages hal-01960838v1

Chapitre d'ouvrage (1)

26RFa Jérôme Leprince,Cindy Neveu,Benjamin Lefranc,Laure Guilhaudis,Isabelle Ségalas-Milazzoet al. Handbook of biologically active peptides, Elsevier, pp.917-923, 2013, 978-0-12-385095-9. ⟨10.1016/B978-0-12-385095-9.00122-6⟩ Chapitre d'ouvrage hal-01972615v1