ISABELLE VAN SEUNINGEN

Identifiants chercheurs

IdHAL :

isabelle-van-seuningen

ORCID :

0000-0002-3131-2694

IdRef :

094282048

ResearcherID :

http://www.researcherid.com/rid/N-6176-2016

Publications

Article dans une revue (160)

Fabrication of a bioreactor combining soft lithography and vat photopolymerisation to study tissues and multicellular organisms under dynamic culture conditions Thomas Meynard,Felix Royer,Robin Houssier,Orégane Bajeux,Sonia Pagetet al. Lab on a Chip, 2025, ⟨10.1039/D5LC00172B⟩ Article dans une revue hal-05325521v1
Identification of metabolite biomarkers for pancreatic neuroendocrine tumours using a metabolomic approach Arnaud Jannin,Sophie Dabo-Niang,Christine Do Cao,Amandine Descat,Stéphanie Espiardet al. European Journal of Endocrinology, 2025, 192 (4), pp.466-480. ⟨10.1093/ejendo/lvaf055⟩ Article dans une revue hal-05478190v1
A coregulatory influence map of glioblastoma heterogeneity and plasticity Chloé Bernhard,Konstantinos Geles,Geoffrey Pawlak,Wajdi Dhifli,Aurélien Dispotet al. npj Precision Oncology, 2025, 9 (1), pp.110. ⟨10.1038/s41698-025-00890-0⟩ Article dans une revue hal-05361628v1
Exploring the role of readthrough-inducing molecule 2,6-diaminopurine to increase immune response against cancer cells Carmen Sandoval Pacheco,Alice M Leroy,Mehdi Derhourhi,Tristan Cardon,Catherine Leroyet al. Molecular Therapy, 2025, 33 (12), pp.6212-6225. ⟨10.1016/j.ymthe.2025.09.024⟩ Article dans une revue hal-05287757v1
Identification of metabolite biomarkers for pancreatic neuroendocrine tumors using a metabolomic approach Arnaud Jannin,Sophie Dabo-Niang,Christine Do Cao,Amandine Descat,Stéphanie Espiardet al. European Journal of Endocrinology, 2025, ⟨10.1093/ejendo/lvaf055⟩ Article dans une revue hal-05028963v1
The kinase domain of TRPM7 interacts with PAK1 and regulates pancreatic cancer cell epithelial-to-mesenchymal transition Julie Auwercx,Bernadette Neve,Alison Vanlaeys,Mathilde Fourgeaud,Ingrid Bourrin-Reynardet al. Cell Death and Disease, 2025, 16 (1), pp.335. ⟨10.1038/s41419-025-07665-2⟩ Article dans une revue hal-05049944v1
Emerging paradigms and recent progress in targeting ErbB in cancers Nicolas Stoup,Maxime Liberelle,Nicolas Lebegue,Isabelle Van Seuningen Trends in Pharmacological Sciences, 2024, Trends in Pharmacological Sciences, 45 (6), pp.552-576. ⟨10.1016/j.tips.2024.04.009⟩ Article dans une revue (article de synthèse) hal-04621567v1
MUC1 Drives the Progression and Chemoresistance of Clear Cell Renal Carcinomas Emma Bourdon,Thomas Swierczewski,Marine Goujon,Nihad Boukrout,Sandy Fellahet al. Cancers, 2024, 16 (2), pp.391. ⟨10.3390/cancers16020391⟩ Article dans une revue inserm-04479812v1
Directions to overcome therapy resistance in cancer Ruth Nussinov,Thomas Weichhart,Zodwa Dlamini,Don Gibbons,Isabelle Van Seuningenet al. Trends in Pharmacological Sciences, 2024, 45 (6), pp.467-471. ⟨10.1016/j.tips.2024.05.001⟩ Article dans une revue hal-05383596v1
A novel anti-galectin-9 immunotherapy limits the early progression of pancreatic neoplastic lesions in transgenic mice Alexandre Quilbe,Rami Mustapha,Belinda Duchêne,Abhishek Kumar,Elisabeth Werkmeisteret al. Frontiers in Immunology, 2023, 14, pp.1267279. ⟨10.3389/fimmu.2023.1267279⟩ Article dans une revue hal-04469183v1
ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells Julien Cicero,Sarah Trouvilliez,Martine Palma,Gaetan Ternier,Laurine Decosteret al. Experimental Hematology & Oncology, 2023, 12 (1), pp.104. ⟨10.1186/s40164-023-00463-6⟩ Article dans une revue hal-04334490v2
Metabolism of pancreatic neuroendocrine tumors: what can omics tell us? Arnaud Jannin,Anne-Frédérique Dessein,Christine Do Cao,Marie-Christine Vantyghem,Benjamin Chevalieret al. Frontiers in Endocrinology, 2023, 14, ⟨10.3389/fendo.2023.1248575⟩ Article dans une revue hal-04273585v1
A Double-Negative Feedback Interaction between miR-21 and PPAR-α in Clear Renal Cell Carcinoma Marine Goujon,Justine Woszczyk,Kelly Gaudelot,Thomas Swierczewski,Sandy Fellahet al. Cancers, 2022, 14 (3), pp.795. ⟨10.3390/cancers14030795⟩ Article dans une revue inserm-03729282v1
TRPM7 Modulates Human Pancreatic Stellate Cell Activation. Julie Auwercx,Philippe Kischel,Thibaut Lefebvre,Nicolas Jonckheere,Alison Vanlaeyset al. Cells, 2022, 11 (14), pp.2255. ⟨10.3390/cells11142255⟩ Article dans une revue hal-03740502v1
Analysis of the proximal promoter of the human colon-specific B4GALNT2 (Sda synthase) gene: B4GALNT2 is transcriptionally regulated by ETS1 Cindy Wavelet-Vermuse,Sophie Groux-Degroote,Dorothée Vicogne,Virginie Cogez,Giulia Venturiet al. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2021, 1864 (11-12), pp.194747. ⟨10.1016/j.bbagrm.2021.194747⟩ Article dans une revue hal-03345208v1
A new pancreatic adenocarcinoma‐derived organoid model of acquired chemoresistance to FOLFIRINOX: first insight of the underlying mechanisms Elsa Hadj Bachir,Charles Poiraud,Sonia Paget,Nicolas Stoup,Soumaya El Moghrabiet al. Biology of the Cell, 2021, 114 (1), pp.32-55. ⟨10.1111/boc.202100003⟩ Article dans une revue hal-03369738v2
Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers Nicolas Jonckheere,Audrey Vincent,Bernadette Neve,Isabelle van Seuningen Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021, 1876 (1), pp.188538. ⟨10.1016/j.bbcan.2021.188538⟩ Article dans une revue hal-03294583v1
Mg2+ Transporters in Digestive Cancers Julie Auwercx,Pierre Rybarczyk,Philippe Kischel,Isabelle Dhennin-Duthille,Denis Chatelainet al. Nutrients, 2021, 13 (1), pp.210. ⟨10.3390/nu13010210⟩ Article dans une revue hal-03195960v1
The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis Nicolas Stoup,Maxime Liberelle,Céline Schulz,Sumeyye Cavdarli,Romain Vasseuret al. Cancers, 2021, 13 (22), pp.5746. ⟨10.3390/cancers13225746⟩ Article dans une revue hal-03641795v1
Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma Nihad Boukrout,Mouloud Souidi,Fatima Lahdaoui,Belinda Duchêne,Bernadette Neveet al. Cancers, 2021, 13 (24), pp.6197. ⟨10.3390/cancers13246197⟩ Article dans une revue hal-03777017v1
Fabricating Silicon Resonators for Analysing Biological Samples Momoko Kumemura,Deniz Pekin,Vivek Anand Menon,Isabelle van Seuningen,Dominique Collardet al. Micromachines, 2021, 12 (12), pp.1546. ⟨10.3390/mi12121546⟩ Article dans une revue (article de synthèse) hal-03501246v1
Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish Ludivine Raby,Pamela Völkel,Shaghayegh Hasanpour,Julien Cicero,Robert-Alain Toillonet al. Cells, 2021, 10 (11), pp.3142. ⟨10.3390/cells10113142⟩ Article dans une revue hal-04488645v1
MUC1 Mitigates Renal Injury and Inflammation in Endotoxin-Induced Acute Kidney Injury by Inhibiting the TLR4-MD2 Axis and Reducing Pro-inflammatory Macrophages Infiltration Jean-Baptiste Gibier,Thomas Swierczewski,Marie Csanyi,Brigitte Hemon,Francois Glowackiet al. Shock, 2021, 56 (4), pp.629-638. ⟨10.1097/SHK.0000000000001742⟩ Article dans une revue hal-03379151v1
Cross-talk between YAP and RAR-RXR Drives Expression of Stemness Genes to Promote 5-FU Resistance and Self-Renewal in Colorectal Cancer Cells Marjolaine Bauzone,Mouloud Souidi,Anne-Frédérique Dessein,Maxence Wisztorski,Audrey Vincentet al. Molecular Cancer Research, 2021, 19 (4), pp.612-622. ⟨10.1158/1541-7786.MCR-20-0462⟩ Article dans une revue hal-04284692v1
EGF-Containing Membrane-Bound Mucins: A Hidden ErbB2 Targeting Pathway? Maxime Liberelle,Nicolas Jonckheere,Patricia Melnyk,Isabelle van Seuningen,Nicolas Lebègue Journal of Medicinal Chemistry, 2020, 63 (10), pp.5074-5088. ⟨10.1021/acs.jmedchem.9b02001⟩ Article dans une revue hal-02955348v1
Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface Lucie Coppin,Arnaud Jannin,Emilie Ait Yahya,Caroline Thuillier,Céline Villenetet al. Cell Death and Disease, 2020, 11 (5), pp.360. ⟨10.1038/s41419-020-2556-3⟩ Article dans une revue hal-03060582v1
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer Maria Paula Roberti,Satoru Yonekura,Connie P. M. Duong,Marion Picard,Gladys Ferrereet al. Nature Medicine, 2020, 26 (6), p. 919-931. ⟨10.1038/s41591-020-0882-8⟩ Article dans une revue hal-03313676v1
Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival Nicolas Jonckheere,Julie Auwercx,Elsa Hadj Bachir,Lucie Coppin,Nihad Boukroutet al. Cancers, 2020, 12 (11), pp.3309. ⟨10.3390/cancers12113309⟩ Article dans une revue hal-03003452v2
Long non-coding RNAs: the tentacles of chromatin remodeler complexes Bernadette Neve,Nicolas Jonckheere,Audrey Vincent,Isabelle van Seuningen Cellular and Molecular Life Sciences, 2020, 78 (4), pp.1139-1161. ⟨10.1007/s00018-020-03646-0⟩ Article dans une revue hal-03195963v1
Direct and Indirect Targeting of HOXA9 Transcription Factor in Acute Myeloid Leukemia. Mélanie Lambert,M Alioui,Samy Jambon,Sabine Depauw,Isabelle Van Seuningenet al. Cancers, 2019, 11 (6), pp.837. ⟨10.3390/cancers11060837⟩ Article dans une revue (article de synthèse) hal-04549198v1
Direct and Indirect Targeting of HOXA9 Transcription Factor in Acute Myeloid Leukemia. Mélanie Lambert,Meryem Alioui,Samy Jambon,Sabine Depauw,Isabelle van Seuningenet al. Cancers, 2019, 11 (6), pp.837. ⟨10.3390/cancers11060837⟩ Article dans une revue hal-02358430v1
Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required Nicolas Jonckheere,Isabelle van Seuningen Annals of translational medicine, 2019, 7 (S1), pp.S43-S43. ⟨10.21037/atm.2019.03.01⟩ Article dans une revue inserm-02341315v1
Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies Audrey Vincent,Aïcha Ouelkdite-Oumouchal,Mouloud Souidi,Julie Leclerc,Bernadette Neveet al. World Journal of Stem Cells, 2019, 11 (11), pp.920-936. ⟨10.4252/wjsc.v11.i11.920⟩ Article dans une revue inserm-02351996v1
MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis Maxime Liberelle,Romain Magnez,Xavier Thuru,Yamina Bencheikh,Séverine Ravezet al. Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-53099-0⟩ Article dans une revue hal-02407901v1
Gemcitabine‐induced epithelial‐mesenchymal transition‐like changes sustain chemoresistance of pancreatic cancer cells of mesenchymal‐like phenotype Mehdi El Amrani,François Corfiotti,Matthieu Corvaisier,Romain Vasseur,Maxence Fulbertet al. Molecular Carcinogenesis, 2019, 58 (11), pp.1985-1997. ⟨10.1002/mc.23090⟩ Article dans une revue inserm-02352000v1
TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727 Vincent Drubay,Nicolas Skrypek,Lucie Cordiez,Romain Vasseur,Céline Schulzet al. Cancers, 2018, 10 (8), pii: E254. ⟨10.3390/cancers10080254⟩ Article dans une revue inserm-02341320v1
Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas. Nicolas Jonckheere,Isabelle van Seuningen Journal of Translational Medicine, 2018, 16 (1), pp.259. ⟨10.1186/s12967-018-1632-2⟩ Article dans une revue hal-02341297v1
Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer Bernadette Neve,Nicolas Jonckheere,Audrey Vincent,Isabelle van Seuningen Cancers, 2018, 10 (11), pp.440. ⟨10.3390/cancers10110440⟩ Article dans une revue inserm-02341333v1
Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22. Rémi Porte,Laurye van Maele,Natalia Muñoz-Wolf,Benoit Foligné,Laure Dumoutieret al. Infection and Immunity, 2017, 85 (2), pp.e00806-16. ⟨10.1128/IAI.00806-16⟩ Article dans une revue inserm-01529315v1
Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt/β-catenin pathway Fatima Lahdaoui,Mathieu Messager,Audrey Vincent,Flora Hec,Anne Gandonet al. Biochemical Journal, 2017, 474 (22), pp.3733-3746. ⟨10.1042/BCJ20170348⟩ Article dans une revue inserm-02341337v1
Lepidic predominant adenocarcinoma and invasive mucinous adenocarcinoma of the lung exhibit specific mucin expression in relation with oncogenic drivers Michaël Duruisseaux,Martine Antoine,Nathalie Rabbe,Anita Rodenas,Anne Mc Leer-Florinet al. Lung Cancer, 2017, 109, pp.92-100. ⟨10.1016/j.lungcan.2017.05.007⟩ Article dans une revue hal-01535623v1
Galectin-3 is a non-classic RNA binding protein that stabilizes the mucin MUC4 mRNA in the cytoplasm of cancer cells Lucie Coppin,Audrey Vincent,Frédéric Frénois,Belinda Duchêne,Fatima Lahdaouiet al. Scientific Reports, 2017, 7, pp.43927. ⟨10.1038/srep43927⟩ Article dans une revue hal-01534451v1
Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma Kelly Gaudelot,Jean-Baptiste Gibier,Nicolas Pottier,Brigitte Hémon,Isabelle van Seuningenet al. Tumor Biology, 2017, 39 (7), pp.101042831770737. ⟨10.1177/1010428317707372⟩ Article dans une revue hal-03313744v1
Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase Jean-Baptiste Gibier,Brigitte Hemon,Melanie Fanchon,Kelly Gaudelot,Nicolas Pottieret al. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2017, 1863 (6), pp.1336 - 1349. ⟨10.1016/j.bbadis.2017.03.023⟩ Article dans une revue inserm-01833348v1
The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting Nicolas Jonckheere,Romain Vasseur,Isabelle Van Seuningen Critical Reviews in Oncology/Hematology, 2017, 111, pp.7-19. ⟨10.1016/j.critrevonc.2017.01.002⟩ Article dans une revue inserm-02341607v1
Hemidesmosome integrity protects the colon against colitis and colorectal cancer Adèle de Arcangelis,Hussein Hamade,Fabien Alpy,Sylvain Normand,Emilie Bruyèreet al. Gut, 2016, 66 (10), pp.gutjnl--2015--310847. ⟨10.1136/gutjnl-2015-310847⟩ Article dans une revue hal-01538539v1
The serrated neoplasia pathway of colorectal tumors: Identification of MUC5AC hypomethylation as an early marker of polyps with malignant potential Florence Renaud,Christophe Mariette,Audrey Vincent,Agnès Wacrenier,Vincent Maunouryet al. International Journal of Cancer, 2016, 138, pp.1472-1481. ⟨10.1002/ijc.29891⟩ Article dans une revue hal-02905823v1
Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse Matthieu Corvaisier,Marjolaine Bauzone,François Corfiotti,Florence Renaud,Mehdi El Amraniet al. Oncotarget, 2016, 7 (35), pp.56699-56712. ⟨10.18632/oncotarget.11057⟩ Article dans une revue hal-03313749v1
The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2 Nicolas Skrypek,Romain Vasseur,Audrey Vincent,Bélinda Duchêne,Isabelle van Seuningenet al. Oncotarget, 2015, 6 (13), pp.10853-1067. ⟨10.18632/oncotarget.3414⟩ Article dans une revue inserm-02341515v1
Targeting MUC4 in pancreatic cancer: miRNAs Nicolas Jonckheere,Fatima Lahdaoui,Isabelle van Seuningen Oncoscience, 2015, 2 (10), pp.799-800. ⟨10.18632/oncoscience.249⟩ Article dans une revue hal-02905858v1
MUC5AC hypomethylation is a predictor of microsatellite instability independently of clinical factors associated with colorectal cancer Florence Renaud,Audrey Vincent,Christophe Mariette,Michel Crépin,Laurence Stechlyet al. International Journal of Cancer, 2015, 136, pp.2811 - 2821. ⟨10.1002/ijc.29342⟩ Article dans une revue hal-02905819v1
Suitability of Surgically Induced Chronic Reflux in Rats for Studying Esophageal Carcinogenesis Caroline Gronnier,Guillaume Piessen,Emmanuelle Leteurtre,Isabelle van Seuningen,Christophe Mariette Annals of Surgery, 2015, 261 (5), pp.e140-e141. ⟨10.1097/SLA.0000000000000474⟩ Article dans une revue hal-03313754v1
The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways Romain Vasseur,Nicolas Skrypek,Belinda Duchêne,Florence Renaud,Daniel Martínez-Maquedaet al. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2015, 1849 (12), pp.1375-1384. ⟨10.1016/j.bbagrm.2015.10.014⟩ Article dans une revue hal-02906327v1
Cryosectioning the intestinal crypt-villus axis: An ex vivo method to study the dynamics of epigenetic modifications from stem cells to differentiated cells Audrey Vincent,Catherine Kazmierczak,Belinda Duchêne,Nicolas Jonckheere,Emmanuelle Leteurtreet al. Stem Cell Research, 2015, 14, ⟨10.1016/j.scr.2014.12.002⟩ Article dans une revue hal-02905864v1
Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells Solange Tréhoux,Fatima Lahdaoui,Yannick Delpu,Florence Renaud,Emmanuelle Leteurtreet al. Biochimica et Biophysica Acta - Molecular Cell Research, 2015, ⟨10.1016/j.bbamcr.2015.05.033⟩ Article dans une revue hal-02905657v1
Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival Thibault Desurmont,Nicolas Skrypek,Alain Duhamel,Nicolas Jonckheere,Guillaume Milletet al. Cancer Science, 2015, 106 (3), pp.262-269. ⟨10.1111/cas.12603⟩ Article dans une revue hal-02954490v1
Mucins and tumor resistance to chemotherapeutic drugs Nicolas Jonckheere,Nicolas Skrypek,Isabelle Van Seuningen Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014, 1846 (1), pp.142-151. ⟨10.1016/j.bbcan.2014.04.008⟩ Article dans une revue inserm-02341531v1
Of autophagy and in vivo pancreatic carcinogenesis: The p53 status matters! Nicolas Jonckheere,Audrey Vincent,Isabelle Van Seuningen Clinics and Research in Hepatology and Gastroenterology, 2014, 38 (4), pp.423-425. ⟨10.1016/j.clinre.2014.04.009⟩ Article dans une revue inserm-02341594v1
MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway Audrey Bouillez,Viviane Gnemmi,Kelly Gaudelot,Brigitte Hemon,Bélinda Ringotet al. Oncotarget, 2014 Article dans une revue hal-02905860v1
Combined NADPH Oxidase 1 and Interleukin 10 Deficiency Induces Chronic Endoplasmic Reticulum Stress and Causes Ulcerative Colitis-Like Disease in Mice Xavier Tréton,Eric Pedruzzi,Cécile Guichard,Yannick Ladeiro,Shirin Sedghiet al. PLoS ONE, 2014, 9 (7), pp.e101669. ⟨10.1371/journal.pone.0101669⟩ Article dans une revue hal-03313755v1
The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways Solange Tréhoux,Bélinda Duchêne,Nicolas Jonckheere,Isabelle van Seuningen Biochemical and Biophysical Research Communications, 2014, ⟨10.1016/j.bbrc.2014.12.025⟩ Article dans une revue hal-02905690v1
Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells Michael Perrais,Christel Rousseaux,Marie-Paule Ducourouble,René Courcol,Pascal Vincentet al. Gastric Cancer, 2014, 17, pp.235-246. ⟨10.1007/s10120-013-0267-5⟩ Article dans une revue hal-02905802v1
Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press Nicolas Jonckheere,Isabelle van Seuningen Tumor Biology, 2014, 35 (4), pp.3941-3942. ⟨10.1007/s13277-013-1390-y⟩ Article dans une revue inserm-02371186v1
Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth Audrey Vincent,Seung-Mo Hong,Chaoxin Hu,Noriyuki Omura,Angela Younget al. Oncotarget, 2014, 5 (9), pp.2575-2587. ⟨10.18632/oncotarget.1842⟩ Article dans une revue hal-02905879v1
MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway Audrey Bouillez,Viviane Gnemmi,Kelly Gaudelot,Brigitte Hémon,Bélinda Ringotet al. Oncotarget, 2014, 5 (3), pp.754-763. ⟨10.18632/oncotarget.1768⟩ Article dans une revue hal-03313775v1
The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells Caroline Gronnier,Emilie Bruyère,Fatima Lahdaoui,Nicolas Jonckheere,Michael Perraiset al. Biochimica et Biophysica Acta - Molecular Cell Research, 2014, ⟨10.1016/j.bbamcr.2014.06.021⟩ Article dans une revue hal-02905652v1
MUC1 drives epithelial–mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter Viviane Gnemmi,Audrey Bouillez,Kelly Gaudelot,Brigitte Hémon,Bélinda Ringotet al. Cancer Letters, 2014, 346 (2), pp.225-236. ⟨10.1016/j.canlet.2013.12.029⟩ Article dans une revue hal-03313770v1
MUC1 Expression in Papillary Thyroid Carcinoma Is Associated with BRAF Mutation and Lymph Node Metastasis; the Latter is the Most Important Risk Factor of Relapse Florence Renaud,Viviane Gnemmi,Patrick Devos,Sébastien Aubert,Michel Crépinet al. Thyroid, 2014, 24 (9), pp.1375-1384. ⟨10.1089/thy.2013.0594⟩ Article dans une revue hal-03313761v1
Estradiol Represses the GD3 Synthase Gene ST8SIA1 Expression in Human Breast Cancer Cells by Preventing NFκB Binding to ST8SIA1 Promoter. Marie Bobowski,Audrey Vincent,Agata Steenackers,Florent Colomb,Isabelle van Seuningenet al. PLoS ONE, 2013, 8 (4), pp.e62559. ⟨10.1371/journal.pone.0062559⟩ Article dans une revue hal-00819798v1
Membrane-bound mucin modular domains: from structure to function. Nicolas Jonckheere,Nicolas Skrypek,Frédéric Frénois,Isabelle van Seuningen Biochimie, 2013, 95 (6), pp.1077-86. ⟨10.1016/j.biochi.2012.11.005⟩ Article dans une revue inserm-00807818v1
The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family. Nicolas Skrypek,Bélinda Duchêne,Mohamed Hebbar,Emmanuelle Leteurtre,Isabelle van Seuningenet al. Oncogene, 2013, 32 (13), pp.1714-23. ⟨10.1038/onc.2012.179⟩ Article dans une revue inserm-00807837v1
Operatively induced chronic reflux in rats: A suitable model for studying esophageal carcinogenesis? Caroline Gronnier,Emilie Bruyère,Guillaume Piessen,Nicolas Briez,Jérôme Botet al. Surgery, 2013, ⟨10.1016/j.surg.2013.05.029⟩ Article dans une revue hal-02905869v1
The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways. Nicolas Jonckheere,Nicolas Skrypek,Johann Merlin,Anne Frédérique Dessein,Patrick Dumontet al. PLoS ONE, 2012, 7 (2), pp.e32232. ⟨10.1371/journal.pone.0032232⟩ Article dans une revue inserm-00807830v1
GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells. Nicolas Jonckheere,Audrey Vincent,Hélène Franquet-Ansart,Janneke Witte-Bouma,Anita Korteland-van Maleet al. BBA - Biochimica et Biophysica Acta, 2012, 1819 (8), pp.869-76. ⟨10.1016/j.bbagrm.2012.04.003⟩ Article dans une revue inserm-00807845v1
Membrane-bound mucin modular domains: From structure to function Nicolas Jonckheere,Frédéric Frénois,Isabelle van Seuningen,Nicolas Q1,Nicolas Skrypeket al. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2012, ⟨10.1016/j.biochi.2012.11.005⟩ Article dans une revue hal-02905700v1
Mucin Muc2 Deficiency and Weaning Influences the Expression of the Innate Defense Genes Reg3b, Reg3c and Angiogenin-4 Nanda Burger-van Paassen,Linda M P Loonen,Janneke Witte-Bouma,Anita Korteland-van Male,Adrianus C J M de Bruijnet al. PLoS ONE, 2012, 7 (6), pp.e38798. ⟨10.1371/journal.pone.0038798⟩ Article dans une revue hal-02905863v1
Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon Mirte Streppel,Audrey Vincent,Radha Mukherjee,Nathaniel Campbell,Shih-Hsun Chenet al. Human Pathology, 2012, 43 (10), pp.1755-1763. ⟨10.1016/j.humpath.2012.01.005⟩ Article dans une revue hal-03313777v1
On the epigenetic origin of cancer stem cells Audrey Vincent,Isabelle van Seuningen Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2012, ⟨10.1016/j.bbcan.2012.03.009⟩ Article dans une revue hal-02905665v1
Tif1γ Suppresses Murine Pancreatic Tumoral Transformation by a Smad4-Independent Pathway David Vincent,Johann Gout,Nicolas Chuvin,Vanessa Arfi,Roxane M. Pommieret al. American Journal of Pathology, 2012, 180 (6), pp.2214-2221. ⟨10.1016/j.ajpath.2012.02.006⟩ Article dans une revue hal-02954464v1
Colonic gene expression patterns of mucin muc2 knockout mice reveal various phases in colitis development1 Peng Lu,Nanda Burger-van Paassen,Maria van Der Sluis,Janneke Witte-Bouma,Jean-Pierre Kerckaertet al. Inflammatory Bowel Diseases, 2011, 17 (10), pp.2047-2057. ⟨10.1002/ibd.21592⟩ Article dans une revue hal-03313788v1
Colitis development during the suckling-weaning transition in mucin Muc2-deficient mice Nanda Burger-van Paassen,Maria van Der Sluis,Janneke Bouma,Anita Korteland-van Male,Peng Luet al. AJP - Gastrointestinal and Liver Physiology, 2011, 301 (4), pp.G667-G678. ⟨10.1152/ajpgi.00199.2010⟩ Article dans une revue hal-03313786v1
The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors. Nicolas Jonckheere,Amélie Velghe,Marie-Paule Ducourouble,Marie-Christine Copin,Ingrid B. Reneset al. FEBS Journal, 2011, 278 (2), pp.282-94. ⟨10.1111/j.1742-4658.2010.07945.x⟩ Article dans une revue inserm-00807850v1
Complex interplay between {beta}-catenin signalling and Notch effectors in intestinal tumorigenesis. Grégory Peignon,Aurélie Durand,Wulfran Cacheux,Olivier Ayrault,Benoît Terriset al. Gut, 2011, 60 (2), pp.166-76. ⟨10.1136/gut.2009.204719⟩ Article dans une revue inserm-00553865v1
The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein Emilie Bruyère,Nicolas Jonckheere,Frédéric Frénois,Christophe Mariette,Isabelle van Seuningen Biochemical and Biophysical Research Communications, 2011, pp.325-329. ⟨10.1016/j.bbrc.2011.08.095⟩ Article dans une revue hal-02905689v1
Transcript Profiling of Elf5 +/2 Mammary Glands during Pregnancy Identifies Novel Targets of Elf5 Renee L Rogers,Isabelle van Seuningen,Jodee Gould,Paul J Hertzog,Matthew J Nayloret al. PLoS ONE, 2010, ⟨10.1371/journal.pone.0013150⟩ Article dans une revue hal-02905862v1
Mucins and Pancreatic Cancer Nicolas Jonckheere,Nicolas Skrypek,Isabelle van Seuningen Cancers, 2010, 2, pp.1794-1812. ⟨10.3390/cancers2041794⟩ Article dans une revue inserm-00807873v1
Intrauterine growth restriction alters postnatal colonic barrier maturation in rats Pascale Fanca-Berthon,Catherine Michel,Anthony Pagniez,Martine Rival,Isabelle van Seuningenet al. Pediatric Research, 2009, 66 (1), pp.47-52. ⟨10.1203/PDR.0b013e3181a2047e⟩ Article dans une revue hal-02662866v1
Clinical impact of MUC1 and MUC4 expression in Barrett-associated oesophageal adenocarcinoma G. Piessen,A. Wacrenier,N. Briez,Jean-Pierre Triboulet,Isabelle van Seuningenet al. Journal of Clinical Pathology, 2009, 62, pp.1144-1146. ⟨10.1136/jcp.2008.060780⟩ Article dans une revue istex hal-02905828v1
The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers Nicolas Jonckheere,Isabelle van Seuningen Biochimie, 2009, ⟨10.1016/j.biochi.2009.09.018⟩ Article dans une revue hal-02905696v1
Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2alpha overexpression. Nicolas Jonckheere,Valérie Fauquette,Laurence Stechly,Nathalie Saint-Laurent,Sébastien Aubertet al. British Journal of Cancer, 2009, 101 (4), pp.637-44. ⟨10.1038/sj.bjc.6605190⟩ Article dans une revue inserm-00410436v1
The regulation of the intestinal mucin MUC2 expression by short chain fatty acids: implications for epithelial protection Nanda Burger-van Paassen,Audrey Vincent,Patrycja J Puiman,Maria van Der Sluis,Janneke Boumaet al. Biochemical Journal, 2009, 420 (2), pp.211-219. ⟨10.1042/BJ20082222⟩ Article dans une revue hal-00479129v1
Mucins: a new family of epigenetic biomarkers in epithelial cancers Isabelle van Seuningen,Audrey Vincent Expert opinion on medical diagnostics, 2009, 3, pp.411 - 427. ⟨10.1517/17530050902852697⟩ Article dans une revue hal-02905792v1
Epigenetics, stem cells and epithelial cell fate Audrey Vincent,Isabelle van Seuningen Differentiation, 2009, pp.99-107. ⟨10.1016/j.diff.2009.07.002⟩ Article dans une revue hal-02905791v1
Qu’est ce que l’épigénétique ? Stratégies d’étude et application au cancer Isabelle van Seuningen Annales de Pathologie, 2009, 29 (5), pp.S28-S30. ⟨10.1016/j.annpat.2009.07.009⟩ Article dans une revue hal-03313794v1
Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking Willy Morelle,Laurence Stechly,Sabine Andre,Isabelle van Seuningen,Nicole Porchetet al. Biological Chemistry, 2009, 390, pp.529 - 544. ⟨10.1515/BC.2009.075⟩ Article dans une revue hal-02905705v1
Signal Pathway of 17β-Estradiol–Induced MUC5B Expression in Human Airway Epithelial Cells Hye Joung Choi,Yoo-Sam Chung,Hyun Jik Kim,Uk Yeol Moon,Yeon Ho Choiet al. American Journal of Respiratory Cell and Molecular Biology, 2009, 40 (2), pp.168-178. ⟨10.1165/rcmb.2007-0377OC⟩ Article dans une revue hal-03313791v1
MUC1, a New Hypoxia Inducible Factor Target Gene, Is an Actor in Clear Renal Cell Carcinoma Tumor Progression Sébastien Aubert,Valérie Fauquette,Brigitte Hémon,Réjane Lepoivre,Nicolas Briezet al. Cancer Research, 2009, 69 (14), pp.5707-5715. ⟨10.1158/0008-5472.CAN-08-4905⟩ Article dans une revue hal-03313790v1
Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice Maria van Der Sluis,Janneke Bouma,Audrey Vincent,Anna Velcich,Kermit Carrawayet al. Laboratory Investigation, 2008, 88 (6), pp.634-642. ⟨10.1038/labinvest.2008.28⟩ Article dans une revue hal-03313909v1
Resistin-like molecule β regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice Rim Belharbi Krimi,Larissa Kotelevets,Laurent Dubuquoy,Pascale Plaisancié,Francine Walkeret al. Inflammatory Bowel Diseases, 2008, 14 (7), pp.931-941. ⟨10.1002/ibd.20420⟩ Article dans une revue hal-03313912v1
IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x} epitopes in the human bronchial mucosa Sophie Groux-Degroote,Marie-Ange Krzewinski-Recchi,Aurélie Cazet,Audrey Vincent,Sylvain Lehouxet al. Biochemical Journal, 2008, 410 (1), pp.213-223. ⟨10.1042/BJ20070958⟩ Article dans une revue hal-00478849v1
The Membrane-Bound Mucins: How Large O-Glycoproteins Play Key Roles in Epithelial Cancers and Hold Promise as Biological Tools for Gene-Based and Immunotherapies Nicolas Jonckheere,Isabelle Van Seuningen Critical Review in Oncogenesis, 2008, 14 (2-3), pp.177-196. ⟨10.1615/CritRevOncog.v14.i2-3.30⟩ Article dans une revue hal-02905788v1
Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells Maria van Der Sluis,Audrey Vincent,Janneke Bouma,Anita Korteland-van Male,Johannes B van Goudoeveret al. Biochemical and Biophysical Research Communications, 2008, ⟨10.1016/j.bbrc.2008.02.158⟩ Article dans une revue hal-02905687v1
IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines Raquel Mejías-Luque,Sandra Peiró,Audrey Vincent,Isabelle van Seuningen,Carme de Bolós Biochimica et Biophysica Acta - Molecular Cell Research, 2008, ⟨10.1016/j.bbamcr.2008.05.020⟩ Article dans une revue hal-02905649v1
IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines Raquel Mejías-Luque,Sandra Peiró,Audrey Vincent,Isabelle van Seuningen,Carme de Bolós Biochimica et Biophysica Acta - Molecular Cell Research, 2008, 1783 (10), pp.1728-1736. ⟨10.1016/j.bbamcr.2008.05.020⟩ Article dans une revue hal-03313911v1
Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in Apc Min/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways Kiyoshi Yamaguchi,Maria Cekanova,Michael F Mcentee,Joo-Heon Yoon,Susan M Fischeret al. Molecular Cancer Therapeutics, 2008, ⟨10.1158/1535-7163.MCT-08-0173⟩ Article dans une revue hal-02905848v1
Activation of MUC1 mucin expression by bile acids in human esophageal adenocarcinomatous cells and tissues is mediated by the phosphatidylinositol 3-kinase Christophe Mariette,Guillaume Piessen,Emmanuelle Leteurtre,Brigitte Hemon,Isabelle van Seuningenet al. Surgery, 2008, ⟨10.1016/j.surg.2007.07.043⟩ Article dans une revue hal-02905866v1
Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases Audrey Vincent,Marie-Paule Ducourouble,Isabelle Van Seuningen FASEB Journal, 2008, 22 (8), pp.3035-3045. ⟨10.1096/fj.07-103390⟩ Article dans une revue hal-02905794v1
Trefoil factor family 3 peptide promotes human airway epithelial ciliated cell differentiation. Pierre Lesimple,Isabelle van Seuningen,Marie-Pierre Buisine,Marie-Christine Copin,Margitta Hinzet al. American Journal of Respiratory Cell and Molecular Biology, 2007, 36 (3), pp.296-303. ⟨10.1165/rcmb.2006-0270OC⟩ Article dans une revue inserm-00143069v1
Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1α Guillaume Piessen,Nicolas Jonckheere,Audrey Vincent,Brigitte Hemon,Marie-Paule Ducouroubleet al. Biochemical Journal, 2007, 402, pp.81 - 91. ⟨10.1042/BJ20061461⟩ Article dans une revue hal-02905759v1
The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells Nicolas Jonckheere,Audrey Vincent,Michaël Perrais,Marie-Paule Ducourouble,Anita Korteland-van Maleet al. Journal of Biological Chemistry, 2007, ⟨10.1074/jbc.M700905200⟩ Article dans une revue hal-02905844v1
Transcription factor AP-2alpha represses both the mucin MUC4 expression and pancreatic cancer cell proliferation. Valérie Fauquette,Sébastien Aubert,Sophie Groux-Degroote,Brigitte Hemon,Nicole Porchetet al. Carcinogenesis / CARCINOGENESIS(LONDON); Carcinogenesis (Oxford), 2007, 28 (11), pp.2305-12. ⟨10.1093/carcin/bgm158⟩ Article dans une revue hal-00164934v1
Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection Maria van Der Sluis,Barbara A.E. de Koning,Adrianus C.J.M. de Bruijn,Anna Velcich,Jules P.P. Meijerinket al. Gastroenterology, 2006, 131 (1), pp.117-129. ⟨10.1053/j.gastro.2006.04.020⟩ Article dans une revue hal-03313916v1
Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1{alpha} Guillaume Piessen,Nicolas Jonckheere,Audrey Vincent,Brigitte Hémon,Marie-Paule Ducouroubleet al. Biochemical Journal, 2006, 402 (1), pp.81-91. ⟨10.1042/BJ20061461⟩ Article dans une revue hal-00478670v1
Metaplasia A Transdifferentiatlon Process that Facilitates Cancer Development: The Model of Gastric Intestinal Metaplasia Patricia Mesquita,Raquel Almeida,Nuno Lunet,Celso Reis,Luis Filipe Santos Silvaet al. Critical Review in Oncogenesis, 2006, 12 (1-2), pp.3-26. ⟨10.1615/CritRevOncog.v12.i1-2.20⟩ Article dans une revue hal-03313915v1
Evidence for a functional genetic polymorphism of the human retinoic acid–metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida Emmanuel Rat,Ingrid Billaut-Laden,Delphine Allorge,Jean-Marc Lo-Guidice,Marie Tellieret al. Birth Defects Research Part A: Clinical and Molecular Teratology, 2006, 76 (6), pp.491-498. ⟨10.1002/bdra.20275⟩ Article dans une revue istex hal-02954484v1
The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation. Marjolaine Bauzone,Mouloud Souidi,Anne-Frédérique Dessein,Maxence Wisztorski,Audrey Vincentet al. Nature Cell Biology, 2006, 8 (4), pp.278-84. ⟨10.1038/ncb1373⟩ Article dans une revue istex inserm-04278051v1
The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells Valérie Fauquette,Michael Perrais,Sylvain Cerulis,Nicolas Jonckheere,Marie-Paule Ducouroubleet al. Biochemical Journal, 2005, 386 (1), pp.35-45. ⟨10.1042/BJ20040706⟩ Article dans une revue hal-02954487v1
The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells Valérie Fauquette,Michael Perrais,Sylvain Cerulis,Nicolas Jonckheere,Marie-Paule Ducouroubleet al. Biochemical Journal, 2005, 386, pp.35 - 45 Article dans une revue hal-02905757v1
Synergistic induction of the MUC4 mucin gene by interferon-γ and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways Mahefatiana Andrianifahanana,Anshu Agrawal,Ajay Singh,Nicolas Moniaux,Isabelle van Seuningenet al. Oncogene, 2005, 24 (40), pp.6143-6154. ⟨10.1038/sj.onc.1208756⟩ Article dans une revue hal-03313918v1
OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells Raquel Almeida,José Almeida,Michal Shoshkes,Nuno Mendes,Patrícia Mesquitaet al. Journal of Pathology, 2005, 207 (4), pp.396-401. ⟨10.1002/path.1861⟩ Article dans une revue hal-03313917v1
Esophageal Carcinoma: Prognostic Differences between Squamous Cell Carcinoma And Adenocarcinoma Christophe Mariette,Laetitia Finzi,Guillaume Piessen,Isabelle van Seuningen,Jean Pierre Triboulet World Journal of Surgery, 2005, 29 (1), pp.39-45. ⟨10.1007/s00268-004-7542-x⟩ Article dans une revue istex hal-03313920v1
The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells Maria van Der Sluis,Monique H M Melis,Nicolas Jonckheere,Marie-Paule Ducourouble,Hans A Bü Ller Aet al. Biochemical and Biophysical Research Communications, 2004, 325, pp.952 - 960. ⟨10.1016/j.bbrc.2004.10.108⟩ Article dans une revue hal-02905675v1
Coordinated Expression of MUC2 and CDX-2 in Mucinous Carcinomas of the Lung Can Be Explained by the Role of CDX-2 as Transcriptional Regulator of MUC2 Patrícia Mesquita,Raquel Almeida,Isabelle van Seuningen,Leonor David American Journal of Surgical Pathology, 2004, 28 (9), pp.1254-1255. ⟨10.1097/01.pas.0000135517.50095.7f⟩ Article dans une revue hal-03313919v1
A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-b in pancreatic carcinogenesis Nicolas Jonckheere,Michael Perrais,Christophe Mariette,Surinder K Batra,Jean-Pierre Aubertet al. Oncogene, 2004, 23, pp.5729 - 5738. ⟨10.1038/sj.onc.1207769⟩ Article dans une revue hal-02905851v1
Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway Christophe Mariette,Michaël Perrais,Emmanuelle Leteurtre,Nicolas Jonckheere,Brigitte Hémonet al. Biochemical Journal, 2004, 377 (3), pp.701-708. ⟨10.1042/bj20031132⟩ Article dans une revue hal-03314562v1
Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway Christophe Mariette,Michael Perrais,Emmanuelle Leteurtre,Nicolas Jonckheere,Brigitte Hemonet al. Biochemical Journal, 2004, 377, pp.701 - 708 Article dans une revue hal-02905712v1
Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-β/Smad4 signalling pathway is potentiated by Sp1 Nicolas Jonckheere,Maria van Der Sluis,Amélie Velghe,Marie-Pierre Buisine,Marjolein Sutmulleret al. Biochemical Journal, 2004, 377, pp.797 - 808. ⟨10.1042/BJ20030948⟩ Article dans une revue hal-02905751v1
Factors Affecting Postoperative Course and Survival After En Bloc Resection for Esophageal Carcinoma Christophe Mariette,Guillaume Taillier,Isabelle van Seuningen,Jean-Pierre Triboulet Annals of Thoracic Surgery, 2004, 78 (4), pp.1177-1183. ⟨10.1016/j.athoracsur.2004.02.068⟩ Article dans une revue istex hal-03314560v1
Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway Michael Perrais,Brigitte Hemon,Isabelle van Seuningen,Christophe Mariette,Michaël Perraiset al. Biochemical Journal, 2004, 377, pp.701 - 708 Article dans une revue hal-02905748v1
Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-β/Smad4 signalling pathway is potentiated by Sp1 Nicolas Jonckheere,Maria van Der Sluis,Amélie Velghe,Marie-Pierre Buisine,Marjolein Sutmulleret al. Biochemical Journal, 2004, 377, pp.797 - 808 Article dans une revue hal-02905715v1
Pattern of recurrence following complete resection of esophageal carcinoma and factors predictive of recurrent disease Christophe Mariette,Jean-Michel Balon,Guillaune Piessen,Sylvain Fabre,Isabelle van Seuningenet al. Cancer, 2003, 97 (7), pp.1616-1623. ⟨10.1002/cncr.11228⟩ Article dans une revue hal-03316294v1
Human MUC2 Mucin Gene Is Transcriptionally Regulated by Cdx Homeodomain Proteins in Gastrointestinal Carcinoma Cell Lines Patrícia Mesquita,Nicolas Jonckheere,Raquel Almeida,Marie-Paule Ducourouble,Jacinta Serpaet al. Journal of Biological Chemistry, 2003, ⟨10.1074/jbc.M309019200⟩ Article dans une revue hal-02905842v1
Induction of MUC2 and MUC5AC Mucins by Factors of the Epidermal Growth Factor (EGF) Family Is Mediated by EGF Receptor/Ras/Raf/Extracellular Signal-regulated Kinase Cascade and Sp1 Michael Perrais,Pascal Pigny,Marie-Christine Copin,Jean-Pierre Aubert,Isabelle van Seuningen Journal of Biological Chemistry, 2002, 277, pp.32258 - 32267. ⟨10.1074/jbc.M204862200⟩ Article dans une revue hal-02905840v1
TRANSCRIPTIONAL REGULATION OF THE 11P15 MUCIN GENES. TOWARDS NEW BIOLOGICAL TOOLS IN HUMAN THERAPY, IN INFLAMMATORY DISEASES AND CANCER? Isabelle van Seuningen,Pascal Pigny,Michael Perrais,Nicole Porchet,Jean-Pierre Aubert Frontiers in Bioscience, 2001, 6 Article dans une revue hal-02905799v1
Influence of culture conditions on the α1,2-fucosyltransferase and MUC gene expression of a transformed cell line MM-39 derived from human tracheal gland cells Philippe Delmotte,Sophie Degroote,Marc Merten,Annie Bernigaud,Isabelle van Seuningenet al. Biochimie, 2001, 83 (8), pp.749-755. ⟨10.1016/S0300-9084(01)01320-7⟩ Article dans une revue istex hal-03316057v1
Transcriptional regulation of the 11p15 mucin genes. towards new biological tools in human therapy, in inflammatory diseases and cancer? Isabelle Van Seuningen Frontiers in Bioscience, 2001, 6 (1), pp.d1216. ⟨10.2741/seuning⟩ Article dans une revue hal-03314990v1
Influence of TNFα on the sialylation of mucins produced by a transformed cell line MM-39 derived from human tracheal gland cells Philippe Delmotte,Sophie Degroote,Marc Merten,Isabelle van Seuningen,Annie Bernigaudet al. Glycoconjugate Journal, 2001, 18 (6), pp.487-497. ⟨10.1023/A:1016038219183⟩ Article dans une revue istex hal-03316059v1
Influence of TNFα on the sialylation of mucins produced by a transformed cell line MM-39 derived from human tracheal gland cells Philippe Delmotte,Sophie Degroote,Marc Merten,Isabelle van Seuningen,Annie Bernigaudet al. Glycoconjugate Journal, 2001, 18 (6), pp.487-497. ⟨10.1023/A:1016038219183⟩ Article dans une revue istex hal-03314995v1
Influence of culture conditions on the α1,2-fucosyltransferase and MUC gene expression of a transformed cell line MM-39 derived from human tracheal gland cells Philippe Delmotte,Sophie Degroote,Marc Merten,Annie Bernigaud,Isabelle van Seuningenet al. Biochimie, 2001, 83 (8), pp.749-755. ⟨10.1016/S0300-9084(01)01320-7⟩ Article dans une revue istex hal-03314993v1
Characterization of Human Mucin Gene MUC4 Promoter Michael Perrais,Pascal Pigny,Marie-Paule Ducourouble,Daniè Le Petitprez,Nicole Porchetet al. Journal of Biological Chemistry, 2001, ⟨10.1074/jbc.M104204200⟩ Article dans une revue hal-02905838v1
Aberrant Expression of Human Mucin Gene MUC5B in Gastric Carcinoma and Cancer Cells Michael Perrais,Pascal Pigny,Marie-Pierre Buisine,Nicole Porchet,Jean-Pierre Aubertet al. Journal of Biological Chemistry, 2001, ⟨10.1074/jbc.M010534200⟩ Article dans une revue hal-02905839v1
Sequence of the 5′-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells Isabelle Van Seuningen,Michaël Perrais,Pascal Pigny,Nicole Porchet,Jean-Pierre Aubert Biochemical Journal, 2000, 348 (3), pp.675-686. ⟨10.1042/bj3480675⟩ Article dans une revue hal-03317695v1
Sequence of the 5'-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells Isabelle van Seuningen,Michaël Perrais,Pascal Pigny,Nicole Porchet,Jean-Pierre Aubert Biochemical Journal, 2000, 348, pp.675 - 686 Article dans une revue hal-02905746v1
Sequence of the 5′-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells Isabelle Van Seuningen,Michaël Perrais,Pascal Pigny,Nicole Porchet,Jean-Pierre Aubert Biochemical Journal, 2000, 348 (3), pp.675-686. ⟨10.1042/bj3480675⟩ Article dans une revue hal-03316039v1
Sequence of the 5′-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells Isabelle Van Seuningen,Michaël Perrais,Pascal Pigny,Nicole Porchet,Jean-Pierre Aubert Biochemical Journal, 2000, 348 (3), pp.675-686. ⟨10.1042/bj3480675⟩ Article dans une revue hal-03316061v1
Sequence of the 5'-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells Isabelle van Seuningen,Michaël Perrais,Pascal Pigny,Nicole Porchet,Jean-Pierre Aubert Biochemical Journal, 2000, 348, pp.675 - 686 Article dans une revue hal-02905708v1
Genomic organization of the 3' region of the human mucin gene MUC5B. Jean-Luc Desseyn,J P Aubert,Isabelle van Seuningen,N Porchet,A Laine Journal of Biological Chemistry, 1997, 272 (27), pp.16873-1683. ⟨10.1074/jbc.272.27.16873⟩ Article dans une revue hal-02177047v1
Diverse molecular interactions of the hnRNP K protein Karol Bomsztyk,Isabelle van Seuningen,Hideaki Suzuki,Oleg Denisenko,Jerzy Ostrowski FEBS Letters, 1997, 403 (2), pp.113-115. ⟨10.1016/S0014-5793(97)00041-0⟩ Article dans une revue hal-03317710v1
Identification of a 42-kDa Nuclear Factor (NF1-MUC5B) from HT-29 MTX Cells That Binds to the 3′ Region of Human Mucin GeneMUC5B Pascal Pigny,Isabelle van Seuningen,Jean Luc Desseyn,Séverine Nollet,Nicole Porchetet al. Biochemical and Biophysical Research Communications, 1996, 220 (1), pp.186-191. ⟨10.1006/bbrc.1996.0378⟩ Article dans une revue istex hal-03316289v1
Zik1, a Transcriptional Repressor That Interacts with the Heterogeneous Nuclear Ribonucleoprotein Particle K Protein Oleg Denisenko,Bruce O'Neill,Jerzy Ostrowski,Isabelle van Seuningen,Karol Bomsztyk Journal of Biological Chemistry, 1996, 271 (44), pp.27701-27706. ⟨10.1074/jbc.271.44.27701⟩ Article dans une revue hal-03317709v1
Human Mucin Genes Assigned to 11p15.5: Identification and Organization of a Cluster of Genes Pascal Pigny,Veronique Guyonnet-Duperat,Alexander Hill,Wendy Pratt,Sylvie Galiegue-Zouitinaet al. Genomics, 1996, 38 (3), pp.340-352. ⟨10.1006/geno.1996.0637⟩ Article dans une revue istex hal-03316037v1
Description of an IL-1-Responsive Kinase That Phosphorylates the K Protein. Enhancement of Phosphorylation by Selective DNA and RNA Motifs Isabelle van Seuningen,Jerzy Ostrowski,Karol Bomsztyk Biochemistry, 1995, 34 (16), pp.5644-5650. ⟨10.1021/bi00016a040⟩ Article dans une revue istex hal-03317708v1
The K Protein Domain That Recruits the Interleukin 1-responsive K Protein Kinase Lies Adjacent to a Cluster of c-Src and Vav SH3-binding Sites Isabelle van Seuningen,Jerzy Ostrowski,Xose Bustelo,Paul Sleath,Karol Bomsztyk Journal of Biological Chemistry, 1995, 270 (45), pp.26976-26985. ⟨10.1074/jbc.270.45.26976⟩ Article dans une revue hal-03317707v1
Western blotting of basic proteins after nondenaturing electrophoresis in acid conditions using the PhastSystem Monique Davril,Marie-Paule Ducourouble,Isabelle Van-Seuningen Electrophoresis, 1993, 14 (1), pp.876-880. ⟨10.1002/elps.11501401139⟩ Article dans une revue istex hal-03317698v1
Involvement of a Signal Transduction Mechanism in ATP-induced Mucin Release from Cultured Airway Goblet Cells K. Chul Kim,Qiao-Xi Zheng,Isabelle Van-Seuningen American Journal of Respiratory Cell and Molecular Biology, 1993, 8 (2), pp.121-125. ⟨10.1165/ajrcmb/8.2.121⟩ Article dans une revue hal-03317696v1
A rapid periodic acid-Schiff staining procedure for the detection of glycoproteins using the phastsystem Isabelle Van-Seuningen,Monique Davril Electrophoresis, 1992, 13 (1), pp.97-99. ⟨10.1002/elps.1150130119⟩ Article dans une revue istex hal-03317700v1
Strong ionic interactions between mucins and two basic proteins, mucus proteinase inhibitor and lysozyme, in human bronchial secretions Isabelle Van-Seuningen,Nicole Houdret,Annette Hayem,Monique Davril International Journal of Biochemistry, 1992, 24 (2), pp.303-311. ⟨10.1016/0020-711X(92)90262-Y⟩ Article dans une revue istex hal-03317704v1
Analysis of the conformation and stability of human bronchial lysozyme by circular dichroism Isabelle Van-Seuningen,Annette Hayem,Monique Davril International Journal of Biochemistry, 1992, 24 (4), pp.593-598. ⟨10.1016/0020-711X(92)90332-U⟩ Article dans une revue istex hal-03317702v1
Separation of the two domains of human mucus proteinase inhibitor: Inhibitory activity is only located in the car☐y-terminal domain Isabelle Van-Seuningen,Monique Davril Biochemical and Biophysical Research Communications, 1991, 179 (3), pp.1587-1592. ⟨10.1016/0006-291X(91)91755-2⟩ Article dans une revue istex hal-03317705v1
Electrotransfer of basic proteins from nondenaturing polyacrylamide acid gels to nitrocellulose: Detection of enzymatic and inhibitory activities and retention of protein antigenicity Isabelle Van-Seuningen,Monique Davril Analytical Biochemistry, 1990, 186 (2), pp.306-311. ⟨10.1016/0003-2697(90)90085-N⟩ Article dans une revue istex hal-03317706v1

Communication dans un congrès (30)

Rôle de macroH2A1.2 dans l'agressivité de l'adénocarcinome pancréatique Laura Paviot,Manon Rigal,Daniel Mudib Nguz,Lucas Degrave,Nicolas Jonckheereet al. 17èmes journées scientifiques du Cancéropole Nord Ouest, Cancéropole Nord Ouest, May 2025, Deauville, France Communication dans un congrès hal-05088725v1
L’expression ectopique de CDX2 dans le pancréas exerce un effet prooncogénique, dépendant du domaine de liaison à l’ADN mais indépendant dudomaine de transactivation Bénédicte Caron,Jeanny Tchiloemba-Biakou,Nicolas Jonckheere,Andréa Thévenot,Mohamed Elatiet al. Club d'Etude des Cellules Epithéliales Digestives, CECED, Mar 2024, Montpellier (34000), France Communication dans un congrès hal-04534767v1
Mechanism for stroma-induced acquired chemoresistance in Pancreatic Adenocarcinoma Ludmila Recoules,Hippolyte Audureau,Jérôme Raffenne,Rémi Samain,Amandine Alardet al. AFRCP - Association Française de Recherches sur le Cancer du Pancréas, Oct 2023, Bordeaux, France Communication dans un congrès hal-04955240v1
Discovery of the first peptide ligand targeting the EGF2 domain of MUC4 that rescues accessibility and sensitivity of pancreatic cancer cells to Herceptin targeted therapy Isabelle Van Seuningen,Nicolas Stoup,Maxime Liberelle,Leila Moum,Nicolas Renaultet al. XXXVIIèmes Journées Scientifiques Annuelles du Club Français du Pancréas (CFP), Club Français du Pancréas; La Cité des Échanges, Marcq-en-Barœul, Sep 2023, Lille, France Communication dans un congrès hal-04547238v1
Development of an instrumented microfluidic system to study chemosensitivity in pancreatic ductal adenocarcinoma Felix Royer,Thomas Meynard,Orégane Bajeux,Robin Houssier,Ørjan Grøttem Martinsenet al. Journée André Verbert 2023, Nov 2023, Lille, France Communication dans un congrès hal-04537958v1
L’alpha-kinase de TRPM7 : un acteur impliqué dans la migration, l’invasion et la TEM des cellules cancéreuses pancréatiques humaines. Julie Auwercx,Bernadette Neve,Alison Vanlaeys,Sylvie Brassart-Pasco,Mathilde Fourgeaudet al. 15èmes journées scientifiques du Cancéropôle Nord-Ouest, Deauville, 2023., 2023, Deauville, France Communication dans un congrès hal-04466150v1
Développement d’un modèle de co-culture d’adénocarcinome pancréatique canalaire au sein d’un système microfluidique pour l’étude des interactions tumeur-stroma et de la chimiorésistance Thomas Meynard,Felix Royer,Sonia Paget,Alejandra Mogrovejo Valdivia,Nathalie Maubonet al. 40 ème réunion du Club d’étude de la cellule épithéliale digestive, Mar 2023, Strasbourg, France Communication dans un congrès hal-04537961v1
Chimiorésistance acquise dans l'adénocarcinome pancréatique Ludmila Recoules,Hippolyte Audureau,Jérôme Raffenne,Rémi Samain,Amandine Alardet al. FSTM - French Society for Tumor microenvironment, Dec 2023, Le Croisic, France Communication dans un congrès hal-04955250v1
Neurotrophins promotes brain metastasis of triple negative breast cancer through Src kinase family activation Julien Cicero,Sarah Trouvilliez,Martine Palma,Gaetan Ternier,Laurine Decosteret al. 1st ONCOLille days 2022, Nov 2022, Lille, France Communication dans un congrès hal-03853963v1
TRPM7 Modulates Human Pancreatic Stellate Cell Activation. Julie Auwercx,Philippe Kischel,Thibault Lefebvre,Nicolas Jonckheere,Alison Vanlaeyset al. XVI International Magnesium Symposium (SDRM)., Jun 2022, Glasgow, United Kingdom Communication dans un congrès hal-04465334v1
Characterization of the first peptide ligand targeting the MUC4EGF domains in the MUC4-ErbB2 complex in pancreatic cancer. Nicolas Stoup,Maxime Liberelle,Nicolas Renault,Patricia Melnyk,Nicolas Jonckheereet al. 3rd ONCOLille phD Days (3 ème journée des doctorants ONCOLille), ONCOLille, Mar 2022, Lille, France Communication dans un congrès hal-04547102v1
Structure-functions relationship and therapeutic targeting of the MUC4-ErbB2 complex in pancreatic cancer Isabelle Van Seuningen,Nicolas Stoup,Maxime Liberelle,Céline Schulz,Leila Moumet al. 16th International Meeting for Mucins in Health and Diseases (Mucin Conference), International Mucin Organizing Committee, Jul 2022, Utrecht (Netherlands), Netherlands Communication dans un congrès hal-04547327v1
Characterization of the first peptide ligand targeting the MUC4EGF domains in the MUC4-ErbB2 complex to reduce pancreatic cancer activity in vitro. Nicolas Stoup,Maxime Liberelle,Nicolas Renault,Patricia Melnyk,Nicolas Jonckheereet al. XXXIXèmes Journées Scientifiques Annuelles du Club d’étude des cellules épithéliales digestives (CECED), Club d’étude des cellules épithéliales digestives; Faculté de médecine de LYON, Mar 2022, Lyon, France Communication dans un congrès hal-04547168v1
In Vitro Study of the Role of TRPM7 Kinase in Metastatic Mechanisms of Pancreatic Cancer Cells. Julie Auwercx,Alison Vanlaeys,Frédéric Hague,Isabelle Dhennin-Duthille,Philippe Kischelet al. 1 st ONCOLille days, Oct 2022, Lille, France Communication dans un congrès hal-04466179v1
3D structural resolution and therapeutic targeting of the MUC4-ErbB2 oncogenic complex in pancreatic cancer: Carbene Footprinting approach. Nicolas Stoup,Maxime Liberelle,Julien Franck,Nicolas Renault,Patricia Melnyket al. Journée Scientifique Annuelle de l’Association française pour la recherche sur le cancer du pancréas (AFRCP), Association française pour la recherche sur le cancer du pancréas; Hopital Beaujon CLICHY, Nov 2021, Clichy, France Communication dans un congrès hal-04546759v1
The EGF domains of MUC4 oncomucin interact with ErbB2 and mediate tumorigenic activity of cancer cells represent new potential therapeutic targets Nicolas Stoup,Maxime Liberelle,Céline Schulz,Romain Vasseur,Romain Magnezet al. 2021 American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting, American Society for Biochemistry and Molecular Biology, Apr 2021, Virtuel Conference, France Communication dans un congrès hal-04547288v1
Rôle du long ARN non-codant UCA1 dans le caractère souche des cellules cancéreuses coliques; analyse d’une méthode monocellulaire pour caractériser la formation des tumorosphères Bernadette Neve,Deniz Pekin,Mouloud Souidi,Audrey Vincent,Isabelle Van Seuningen Journées scientifiques du CNO, Cancéropôle Nord-Ouest, Oct 2021, Deauville, France Communication dans un congrès hal-04538342v1
Characterization of the first peptide ligand targeting the MUC4EGF domains in the MUC4-ErbB2 complex in pancreatic cancer. Nicolas Stoup,Maxime Liberelle,Nicolas Renault,Patricia Melnyk,Nicolas Jonckheereet al. 13èmes Journées Scientifiques Annuelles du Cancéropole Nord-Ouest, Cancéropole Nord-Ouest; Centre International de DEAUVILLE, Oct 2021, Deauville, France Communication dans un congrès hal-04546733v1
Engineering microscale biomimetic hydroscaffold for dynamic three-dimensional modeling of pancreatic cancer Frederick De Miollis,Zied Souguir,Charles Poiraud,Joseph de Saxce,Lucie Dercourtet al. 2021 IEEE 34th International Conference on Micro Electro Mechanical Systems (MEMS), Jan 2021, Gainesville, United States. pp.407-410, ⟨10.1109/MEMS51782.2021.9375317⟩ Communication dans un congrès hal-03450959v1
Magnesium transporters: discovering new potential biomarkers in digestive cancers. Julie Auwercx,Pierre Rybarczyk,Philippe Kischel,Isabelle Dhennin-Duthille,Denis Chatelainet al. XV International Magnesium Symposium (SDRM)., Jun 2021, online virtual meeting, United Kingdom Communication dans un congrès hal-04465355v1
The role of TRPM7 kinase-domain: Looking for new partners in pancreatic ductal adenocarcinoma. Julie Auwercx,Alison Vanlaeys,Frédéric Hague,Philippe Kischel,Bernadette Neveet al. CANTHER PhD Day 2021, CANcer Heterogeneity, Plasticity and Resistance to THERapies., Mar 2021, Lille (France), France Communication dans un congrès inserm-04541485v1
Pnliprp1 hypermethylation in human exocrine pancreas reveals a link between diabetes and pancreatic cancer Amna Khamis,Mickael Canouil,Lorella Marselli,Raphaël Boutry,Mara Suleimanet al. 56th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD)., 2020, virtual meeting, United Kingdom Communication dans un congrès hal-04465919v1
Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers. Alexandre Quilbe,Rami Mustapha,Belinda Duchêne,S Renaud,Clémentine de Schutteret al. Club Français du Pancréas, 2019, Bron, France Communication dans un congrès hal-04465692v1
Roles of MUC4-miR-210 in pancreatic carcinogenesis and Chemotherapy resistance. Nihad Boukrout,Fatima Lahdaoui,Céline Schulz,Romain Vasseur,Belinda Duchêneet al. Mucins in health and disease (15th International Workshop on Carcinoma-associated Mucins), 2019, Cambridge, United Kingdom Communication dans un congrès hal-04465368v1
Interactions MUC4-canaux ioniques TRPM7 et KCa3.1 dans l’adénocarcinome pancréatique Alison Vanlaeys,Bernadette Neve,Mouloud Souidi,Isabelle Van Seuningen,Halima Ouadid-Ahidouchet al. 2ieme Journée nationale “canaux ioniques et cancer”, Canaux et Connexines dans le Cancer et les Cellules Souches (4CS), Jul 2018, Poitiers (FR), France Communication dans un congrès inserm-04541464v1
Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers Alexandre Quilbe,Rami Mustapha,S Renaud,Belinda Duchêne,Clémentine de Schutteret al. 4ème Journée Scientifique de l’Association pour la Recherche sur le Cancer du pancréas (AFRCP), 2018, Clichy, France Communication dans un congrès hal-04465715v1
Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers Alexandre Quilbe,Rami Mustapha,S Renaud,Belinda Duchêne,Clémentine de Schutteret al. 11èmes journées scientifiques du Cancéropole Nord Ouest, 2018, Deauville, France Communication dans un congrès hal-04465768v1
Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers Alexandre Quilbe,Rami Mustapha,S Renaud,Belinda Duchêne,Clémentine de Schutteret al. 5th European Congress of Immunology, 2018, Amsterdam, Netherlands Communication dans un congrès hal-04465749v1
Strategy of inhibition of TRPM7 channel in pancreatic cancer cells by CRISPR/Cas9. Alison Vanlaeys,Bernadette Neve,Mouloud Souidi,Isabelle van Seuningen,Halima Ouadid-Ahidouchet al. 4ème Journée Scientifique de l’Association pour la Recherche sur le Cancer du pancréas (AFRCP), 2018, Clichy, France Communication dans un congrès hal-04465699v1
The MUC4 membrane-bound mucin mediates FOLFIRINOX drugs resistance of human pancreatic cancer cells. Nicolas Skrypek,Luc Kotzmann,Romain Vasseur,Fatima Lahdaoui,Belinda Duchêneet al. Mucins in health and disease (13th International Workshop on Carcinoma-associated Mucins), 2015, Cambridge, United Kingdom Communication dans un congrès hal-04465781v1

Poster de conférence (37)

Development of a microfluidic system for the study of Schistosoma mansoni parasitic adult worms in dynamic and hypoxic culture conditions Robin Houssier,Orégane Bajeux,Thomas Meynard,Felix Royer,Aurélie Parmentieret al. Microphysiolocal Systems World Summit 2025, Jun 2025, Bruxelles, Belgium Poster de conférence hal-05411008v1
Development of a 3D microfluidic model of pancreatic adenocarcinoma integrating the mechanical stimuli of the tumor microenvironment Orégane Bajeux,Robin Houssier,Félix Royer,Thomas Meynard,Sonia Pagetet al. Microphysiolocal Systems World Summit 2025, Jun 2025, Bruxelles, Belgium Poster de conférence hal-05411001v1
Mechanism for stroma-induced acquired chemoresistance in pancreatic adenocarcinoma Ludmila Recoules,Hippolyte Audureau,Jérôme Raffenne,Rémi Samain,Amandine Alardet al. Toulouse OncoWeek, Feb 2025, Toulouse, France Poster de conférence hal-04955230v1
Characterization of 2′-5′-oligoadenylate synthetase (OAS) genes as MUC4-associated new biomarkers in pancreatic adenocarcinoma Nicolas Jonckheere,Diane Ghesquiere,Julie Auwercx,Lucie Coppin,Isabelle Van Seuningen Mucins in health and Disease, Jun 2024, Gottenburg, Sweden Poster de conférence hal-04594977v1
Single cell analysis for intrinsic stemness potential of cancer Bernadette Neve,Aude Sivery,Isabelle Van Seuningen,Anthony Treizebré,Audrey Vincent 5th Sunrise meeting, May 2024, Ajaccio, France. Poster de conférence hal-04589665v1
Mechanism for stroma-induced acquired chemoresistance in Pancreatic Adenocarcinoma Ludmila Recoules,Hippolyte Audureau,Jérôme Raffenne,Rémi Samain,Amandine Alardet al. European Pancreatic Club, Jun 2024, Saint Jacques de Compostelle, Spain Poster de conférence hal-04955262v1
Rôle de macroH2A1.2 dans l'aggressivité de l'adénocarcinome pancréatique Laura Paviot,Lucas Degrave,Nihad Boukrout,Nicolas Jonckheere,Isabelle Van Seuningenet al. 16èmes journées scientifiques du Cancéropole Nord Ouest, May 2024, Deauville, France Poster de conférence hal-04591731v1
Le premier peptide ligand ciblant les domaines EGF de la mucine MUC4 restaure la sensibilité d’ErbB2 à l’Herceptin dans le cancer du pancréas Nicolas Stoup,Maxime Liberelle,Nicolas Renault,Thomas Meynard,Patricia Melnyket al. 15èmes Journées Scientifiques Annuelles du Cancéropole Nord-Ouest, May 2023, Deauville, France Poster de conférence hal-04547431v1
Development of an instrumented microfluidic system to study chemoresistance in pancreatic ductal adenocarcinoma Thomas Meynard,Félix Royer,Orégane Bajeux,Robin Houssier,Clemens Wagneret al. Microphysiological Systems World Summit 2023, Jun 2023, Berlin, Germany Poster de conférence hal-04480724v1
Development of a 3D co-culture model within a microfluidic system to study pancreatic tumor stroma interactions and drug resistance. Thomas Meynard,Felix Royer,Sonia Paget,Alejandra Mogrovejo Valdivia,Nathalie Maubonet al. FEBS 2023, Jul 2023, Tours, France Poster de conférence hal-04537951v1
Développement d’un modèle de co-culture 3D d’adénocarcinome pancréatique canalaire au sein d’un système microfluidique pour l’étude des interactions tumeur-stroma et de la réponse aux traitements chimiothérapeutiques. Thomas Meynard,Felix Royer,Sonia Paget,Zied Souguir,Antonino Bongiovaniet al. Cancéropôle Nord-Ouest 2023, May 2023, Deauville, France Poster de conférence hal-04537954v1
Développement d’un modèle de co-culture 3D d’adénocarcinome pancréatique canalaire au sein d’un système microfluidique pour l’étude des interactions tumeur-stroma et de la chimiorésistance. Thomas Meynard,Felix Royer,Orégane Bajeux,Robin Houssier,Sonia Pagetet al. Club français du pancréas 2023, Sep 2023, Lille, France Poster de conférence hal-04537949v1
Développement d’un système microfluidique instrumenté pour l’étude de la chimiosensibilité de l’adénocarcinome pancréatique canalaire Felix Royer,Thomas Meynard,Orégane Bajeux,Robin Houssier,Ørjan Grøttem Martinsenet al. Club Français du Pancréas, Sep 2023, Lille, France Poster de conférence hal-04537944v1
The first peptide ligand targeting the EGF domains of MUC4 rescues Herceptin accessibility to ErbB2 in pancreatic cancer cells. Nicolas Stoup,Maxime Liberelle,Nicolas Renault,Patricia Melnyk,Nicolas Jonckheereet al. 1er séminaire international de l’institut ONCOLILLE, Nov 2022, Lille, France Poster de conférence hal-04548329v1
Résolution structural 3D et ciblage thérapeutique du complexe oncogénique MUC4-ErbB2 dans le cancer du pancréas. Nicolas Stoup,Maxime Liberelle,Julien Franck,Nicolas Renault,Patricia Melnyket al. 14èmes Journées Scientifiques Annuelles du Cancéropole Nord-Ouest (CNO), May 2022, Deauville, France Poster de conférence hal-04547404v1
Resensitizing ErbB2 to trastuzumab in pancreatic cancer : identification and characterization of the first peptide ligand targeting the MUC4EGF domains Nicolas Stoup,Maxime Liberelle,Nicolas Renault,Patricia Melnyk,Nicolas Jonckheereet al. 16th International Meeting for Mucins in Health and Diseases (Mucin Conference), Jul 2022, Utrecht (Netherlands), Netherlands Poster de conférence hal-04547486v1
Abstract 2965: Epigenetic mechanisms involved in acquired resistance to combined chemotherapies in digestive cancer cells Elsa Hadj Bachir,Charles Poiraud,Hugo Claux,Soumaya El Moghrabi,Sonia Pagetet al. AACR Annual Meeting 2022, 2022, New Orleans (Louisiana), United States. 82 (12_Supplement), pp.2965-2965, 2022, ⟨10.1158/1538-7445.AM2022-2965⟩ Poster de conférence hal-04465616v1
Bioinformatics identification of key regulators associated with MUC4 expression in pancreatic adenocarcinoma. Nicolas Jonckheere,Julie Auwercx,Elsa Hadj Bachir,Lucie Coppin,Audrey Vincentet al. Mucins in health and Disease, Jul 2022, Utrecht (Netherland), Netherlands Poster de conférence hal-04465160v1
MUC4 interactants: to infinity and beyond ? Nicolas Stoup,Tristan Girgin,Maxime Liberelle,Leila Moum,Nicolas Lebègueet al. 16th International Meeting for Mucins in Health and Diseases (Mucin Conference), Jul 2022, Utrecht (Netherlands), Netherlands Poster de conférence hal-04547497v1
Mechanobiological characterization of a 3D in vitro pancreatic ductal adenocarcinoma model and the study of tumor-stroma interaction. Thomas Meynard,Felix Royer,Sonia Paget,Zied Souguir,Antonino Bongiovaniet al. ONCOLille days, Nov 2022, Lille, France Poster de conférence hal-04537957v1
L’alpha-kinase de TRPM7: comprendre son rôle dans les propriétés invasives de l’adénocarcinome canalaire pancréatique Julie Auwercx,Alison Vanlaeys,Isabelle Dhennin-Duthille,Philippe Kischel,Frédéric Hagueet al. Journées scientifiques du Cancéropôle Nord-Ouest (CNO) 2022, 2022, Deauville, France Poster de conférence hal-04465802v1
Établissement d’une signature prédictive de la survie globale des patients atteints de cancer colique basée sur le profil d’expression d’enzymes responsables de modifications épigénétiques. Elsa Hadj Bachir,Bernadette Neve,Guillaum Piessen,Emmanuelle Leteurtre,Florence Renaudet al. Journées scientifiques du Cancéropôle Nord-Ouest (CNO) 2022, 2022, Deauville, France Poster de conférence hal-04465808v1
MUC4 interactants: to infinity and beyond. Nicolas Stoup,Tristan Girgin,Maxime Liberelle,Leila Moum,Nicolas Jonckheereet al. Mucins in health and Disease, Jul 2022, Utrecht (Netherland), Netherlands Poster de conférence hal-04465179v1
Development of a microfluidic system to study tumor-stroma interactions and drug sensitivity Felix Royer,Thomas Meynard,Robin Houssier,Isabelle Van Seuningen,Vincent Senez ONCOLille Days 2022, Nov 2022, Lille, France Poster de conférence hal-04537947v1
MAGNESIUM TRANSPORTERS EXPRESSION AND PROGNOSTIC IMPACT IN DIGESTIVE CANCERS Julie Auwercx,Pierre Rybarczyk,Philippe Kischel,Isabelle Dhennin-Duthille,Denis Chatelainet al. Future Physiology 2021, Apr 2021, On line conference, United Kingdom Poster de conférence hal-04465644v1
Characterization of the first peptide ligand targeting the MUC4EGF domains in the MUC4-ErbB2 complex in pancreatic cancer Nicolas Stoup,Maxime Liberelle,Nicolas Renault,Patricia Melnyk,Nicolas Jonckheereet al. Congrès Annuel de la Société Française de Biochimie et Biologie Moléculaire (SFBBM), Jul 2021, Paris, France Poster de conférence hal-04547378v1
Abstract LB106: The EGF domains of MUC4 oncomucin interact with ErbB2 and mediate tumorigenic activity of cancer cells represent new potential therapeutic targets Nicolas Stoup,Maxime Liberelle,Céline Schulz,Romain Vasseur,Romain Magnezet al. AACR Annual Meeting 2021, 2021, Philadelphia, United States. 81 (13_Supplement), pp.LB106-LB106, 2021, ⟨10.1158/1538-7445.AM2021-LB106⟩ Poster de conférence hal-04465601v1
Expression des transporteurs au magnésium et impact pronostic dans les cancers digestifs. Julie Auwercx,Pierre Rybarczyk,Philippe Kischel,Isabelle Dhennin-Duthille,Denis Chatelainet al. Journées scientifiques du Cancéropôle Nord-Ouest (CNO) 2021, 2021, Deauville, France Poster de conférence hal-04465849v1
Le rôle du domaine kinase de TRPM7 : A la recherche de nouveaux partenaires d’interaction dans l’adénocarcinome canalaire pancréatique. Julie Auwercx,Alison Vanlaeys,Frédéric Hague,Philippe Kischel,Bernadette Neveet al. Club Français du Pancréas, 2021, Bron, France Poster de conférence hal-04465863v1
MUC1: an actor in chemoresistance and a new therapeutic target in renal cell carcinoma Thomas Swierczewski,Jean-Baptiste Gibier,Brigitte Hémon,Isabelle Van Seuningen,Viviane Gnemmiet al. 12ème journées scientifiques du Cancéropôle Nord-Ouest, May 2019, Deauville, France Poster de conférence hal-04540853v1
Roles of the MUC4-miRNA loop in pancreatic carcinogenesis and resistance to chemotherapy. Nihad Boukrout,Fatima Lahdaoui,Céline Schulz,Romain Vasseur,Belinda Duchêneet al. Pancreatic cancer symposium, 2019, Toulouse, France Poster de conférence hal-04465665v1
Roles of the MUC4-miRNA loop in pancreatic carcinogenesis and chemoresistance. Nihad Boukrout,Fatima Lahdaoui,Céline Schulz,Romain Vasseur,Belinda Duchêneet al. 12èmes journées scientifiques du Cancéropôle Nord-Ouest, 2019, Deauville, France Poster de conférence hal-04466063v1
Evaluation in vitro et in vivo d'une Nouvelle Stratégie d’Immunothérapie ciblant la Galectine-9 dans un modèle de cancer pancréatique. Alexandre Quilbe,Rami Mustapha,S Renaud,Belinda Duchêne,Clémentine de Schutteret al. 12èmes journées scientifiques du Cancéropôle Nord-Ouest, 2019, Deauville, France Poster de conférence hal-04466053v1
Roles of the MUC4-miRNA loop in pancreatic carcinogenesis and chemoresistance. Nihad Boukrout,Fatima Lahdaoui,Céline Schulz,Romain Vasseur,Belinda Duchêneet al. 11èmes journées scientifiques du Cancéropôle Nord-Ouest, 2018, Deauville, France Poster de conférence hal-04466077v1
Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers. Alexandre Quilbe,Rami Mustapha,S Renaud,Belinda Duchêne,Clémentine de Schutteret al. 11èmes journées scientifiques du Cancéropôle Nord-Ouest, 2018, Deauville, France Poster de conférence hal-04466070v1
MUC1: an actor in chemoresistance and a new therapeutic target in renal cell carcinoma Brigitte Hémon,Thomas Swierczewski,Jean-Baptiste Gibier,Isabelle Van Seuningen,Viviane Gnemmiet al. 10 ème journées scientifiques du Cancéropôle Nord-Ouest, May 2018, Deauville, France Poster de conférence hal-04540838v1
Analyzing lncRNA UCA1 in cancerous cells by targeted exon deletion based on CRISPR/Cas9. Mouloud Souidi,Amandine Legrand,Isabelle Van Seuningen,Bernadette Neve Genome Engineering and Synthetic Biology (3rd) conference, Jan 2018, Bruges, Belgique, Belgium Poster de conférence hal-04538454v1

Chapitre d'ouvrage (2)

Single-Cell Analysis May Shed New Lights on the Role of LncRNAs in Chemoresistance in Gastrointestinal Cancers Bernadette Neve,Nicolas Jonckheere,Audrey Vincent,Isabelle van Seuningen The Chemical Biology of Long Noncoding RNAs, 11, Springer International Publishing, pp.229-253, 2020, RNA Technologies, ⟨10.1007/978-3-030-44743-4_9⟩ Chapitre d'ouvrage inserm-04541444v1
Reporter, Inducible And Synthetic Promoters: Engineering Tools To Study Gene Regulation And Biological Systems Nicolas Jonckheere,Isabelle Van Seuningen The Analysis of Regulatory DNA: Current Developments, Knowledge and Applications Uncovering Gene Regulation, BENTHAM SCIENCE PUBLISHERS, pp.149-161, 2013, ⟨10.2174/9781608054923113010010⟩ Chapitre d'ouvrage hal-04541719v1

Brevet (1)

Nutritional composition for use in gut maturation Mona Mischke,Ingrid Brunhilde Renes,Isabelle Van Seuningen,Audrey Vincent Netherlands, Patent n° : WO2021152176A1. 2021 Brevet hal-04540196v1

Pré-publication, Document de travail (5)

The kinase domain of TRPM7 interacts with PAK1 and regulates pancreatic cancer cell epithelial-to-mesenchymal transition Mathieu Gautier,Julie Auwercx,Bernadette Neve,Alison Vanlaeys,Ingrid Bourrin-Reynardet al. 2025 Pré-publication, Document de travail hal-04882162v1
A coregulatory influence map of glioblastoma heterogeneity and plasticity - From cells in vitro to tumors and back again Chloe Bernhard,Konstantinos Geles,Geoffrey Pawlak,Wajdi Dhifli,Aurelien Dispotet al. 2024 Pré-publication, Document de travail hal-04750456v1
Long non-coding RNA UCA1 affects chromatin remodeling via SMARCA2-containing SWI/SNF complex in human colorectal cancer Bernadette Neve,Elsa Hadj Bachir,Belinda Duchêne,Mouloud Souidi,Martin Figeacet al. 2026 Pré-publication, Document de travail hal-05457725v1
The EGF domains of MUC4 oncomucin interact with ErbB2 and mediate tumorigenic activity of cancer cells represent new potential therapeutic targets Nicolas Stoup,Maxime Liberelle,Céline Schulz,Romain Vasseur,Romain Magnezet al. 2023 Pré-publication, Document de travail hal-04338884v1
TGF-βRII knock-down promotes tumor growth and chemoresistance to gemcitabine of pancreatic cancer cells via phosphorylation of STAT3 Vincent Drubay,Nicolas Skrypek,Lucie Cordiez,Romain Vasseur,Céline Schulzet al. 2020 Pré-publication, Document de travail hal-02954689v1