Isabelle VILA

Publications

Article dans une revue (24)

Deltaviruses spread through a viral Trojan Horse Joe Mckellar,Aurélien Fouillen,Sébastien Lyonnais,Marie-Pierre Blanchard,Florian Seigneuretet al. Cell, 2026, pp.S0092-8674(26)00165-0. ⟨10.1016/j.cell.2026.01.037⟩ Article dans une revue hal-05553878v1
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling Hanane Chamma,Soumyabrata Guha,Roger Junior Eloiflin,Adeline Augereau,Pierre Le Harset al. Nature Communications, 2025, 16 (1), pp.9827. ⟨10.1038/s41467-025-65713-z⟩ Article dans une revue hal-05361456v1
The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA Jesse Rabinowitz,Isabelle Vila,Charlotte Luchsinger,Cinzia Bertelli,Moritz Schüssleret al. Journal of Biological Chemistry, 2025, 301 (8), pp.110430. ⟨10.1016/j.jbc.2025.110430⟩ Article dans une revue hal-05362503v1
Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions Dylan J Harney,Michelle Cielesh,Georgia E Roberts,Isabelle K Vila,Barney Viengkhouet al. Cell Reports, 2023, 42 (6), pp.112559. ⟨10.1016/j.celrep.2023.112559⟩ Article dans une revue hal-04241406v1
DNA damage repair kinase DNA‐PK and cGAS synergize to induce cancer‐related inflammation in glioblastoma Clara Taffoni,Johanna Marines,Hanane Chamma,Soumyabrata Guha,Mathilde Saccaset al. EMBO Journal, 2023, 42 (7), pp.e111961. ⟨10.15252/embj.2022111961⟩ Article dans une revue hal-03923380v1
The unexpected role of the STING protein in lipid metabolism Isabelle K Vila,Nadine Laguette Comptes Rendus. Biologies, 2023, 346, pp.29 - 33. ⟨10.5802/crbiol.110⟩ Article dans une revue hal-04241169v1
Harnessing the cooperation between DNA‐PK and cGAS in cancer therapies Clara Taffoni,Moritz Schüssler,Isabelle K Vila,Nadine Laguette BioEssays, 2023, ⟨10.1002/bies.202300045⟩ Article dans une revue (article de synthèse) hal-04125754v1
Multiplexed targeted analysis of polyunsaturated fatty acids and oxylipins using liquid chromatography-tandem mass spectrometry Evgenia Turtoi,Jérémy Jeudy,Gilles Valette,Christine Enjalbal,Isabelle K Vilaet al. STAR Protocols, 2023, 4 (3), pp.102226. ⟨10.1016/j.xpro.2023.102226⟩ Article dans une revue (article de synthèse) hal-04241222v1
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses Isabelle Vila,Hanane Chamma,Alizée Steer,Mathilde Saccas,Clara Taffoniet al. Cell Metabolism, 2022, 34 (1), pp.125-139.e8. ⟨10.1016/j.cmet.2021.12.007⟩ Article dans une revue hal-03520564v1
Alternative pathways driven by STING: From innate immunity to lipid metabolism Isabelle Vila,Soumyabrata Guha,Joanna Kalucka,David Olagnier,Nadine Laguette Cytokine and Growth Factor Reviews, 2022, ⟨10.1016/j.cytogfr.2022.08.006⟩ Article dans une revue hal-03807587v1
Protocol to induce and assess cGAS-STING pathway activation in vitro Hanane Chamma,Soumyabrata Guha,Nadine Laguette,Isabelle Vila STAR Protocols, 2022, 3 (2), pp.101384. ⟨10.1016/j.xpro.2022.101384⟩ Article dans une revue hal-03807593v1
Activation of STING in the pancreatic tumor microenvironment: a novel therapeutic opportunity Hanane Chamma,Isabelle Vila,Clara Taffoni,Andrei Turtoi,Nadine Laguette Cancer Letters, 2022, 538, pp.215694. ⟨10.1016/j.canlet.2022.215694⟩ Article dans une revue hal-03668657v1
Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes Clara Taffoni,Alizée Steer,Johanna Marines,Hanane Chamma,Isabelle Vilaet al. Frontiers in Immunology, 2021, 12, pp.660560. ⟨10.3389/fimmu.2021.660560⟩ Article dans une revue hal-03380383v2
Animal Models for the Study of Nucleic Acid Immunity: Novel Tools and New Perspectives Isabelle K Vila,Maxence Fretaud,Dimitrios Vlachakis,Nadine Laguette,Christelle Langevin Journal of Molecular Biology, 2020, 432 (20), pp.5529-5543. ⟨10.1016/j.jmb.2020.08.016⟩ Article dans une revue (article de synthèse) hal-02989107v1
A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity Isabelle K Vila,Mi Kyung Park,Stephanie Rebecca Setijono,Yixin Yao,Hyejin Kimet al. JCI Insight, 2019, 4 (13), pp.e128269. ⟨10.1172/jci.insight.128269⟩ Article dans une revue hal-04793048v1
PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression Mi Kyung Park,Yixin Yao,Weiya Xia,Stephanie Rebecca Setijono,Jae Hwan Kimet al. Nature Communications, 2019, 10 (1), pp.636. ⟨10.1038/s41467-019-08481-x⟩ Article dans une revue hal-04765231v1
A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy Isabelle Vila,Yixin Yao,Goeun Kim,Weiya Xia,Hyejin Kimet al. Cancer Cell, 2017, 31 (2), pp.208-224. ⟨10.1016/j.ccell.2017.01.003⟩ Article dans une revue hal-04765198v1
A new duet in cancer biology: AMPK the typical and UBE2O the atypical Isabelle Vila,Su Jung Song,Min Sup Song Molecular & Cellular Oncology, 2017, 4 (3), pp.e1304846. ⟨10.1080/23723556.2017.1304846⟩ Article dans une revue hal-04765241v1
Long-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting Danesh Sopariwala,Vikas Yadav,Pierre-Marie Badin,Neah Likhite,Megha Shethet al. Scientific Reports, 2017, 7 (1), pp.10237. ⟨10.1038/s41598-017-10238-9⟩ Article dans une revue hal-04765235v1
Exercise-like effects by Estrogen-related receptor-gamma in muscle do not prevent insulin resistance in db/db mice Pierre-Marie Badin,Isabelle Vila,Danesh Sopariwala,Vikas Yadav,Sabina Lorcaet al. Scientific Reports, 2016, 6 (1), pp.26442. ⟨10.1038/srep26442⟩ Article dans une revue hal-04765192v1
Defective Natriuretic Peptide Receptor Signaling in Skeletal Muscle Links Obesity to Type 2 Diabetes Marine Coué,Pierre-Marie Badin,Isabelle Vila,Claire Laurens,Katie Loucheet al. Diabetes, 2015, 64 (12), pp.4033-4045. ⟨10.2337/db15-0305⟩ Article dans une revue hal-05204309v1
Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis. Isabelle K Vila,Pierre-Marie Badin,Marie-Adeline Marques,Laurent Monbrun,Corinne Lefortet al. Plant Cell Reports, 2014, 7 (4), pp.1116-29. ⟨10.1016/j.celrep.2014.03.062⟩ Article dans une revue inserm-00991860v1
Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass. Amandine Girousse,Geneviève Tavernier,Carine Valle,Cedric Moro,Niklas Mejhertet al. PLoS Biology, 2013, 11 (2), pp.e1001485. ⟨10.1371/journal.pbio.1001485⟩ Article dans une revue inserm-00841328v1
High-fat diet-mediated lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle. Pierre-Marie Badin,Isabelle K. Vila,Katie Louche,Aline Mairal,Marie-Adeline Marqueset al. Endocrinology, 2013, 154 (4), pp.1444-53. ⟨10.1210/en.2012-2029⟩ Article dans une revue inserm-00841051v1

Pré-publication, Document de travail (4)

Regulation of lipid metabolism is a primordial function of STING Soumyabrata Guha,Joanna Re,Morgane Chemarin,Stéphane Grégoire,Yasmine Messaoud-Naceret al. 2026 Pré-publication, Document de travail hal-05488459v1
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling Hanane Chamma,Soumyabrata Guha,Moritz Schussler,Yasmine Messaoud-Nacer,Pierre Le Harset al. 2025 Pré-publication, Document de travail (preprint/prepublication) hal-04935185v1
DNA-PK controls cyclic dinucleotide-associated type I Interferon responses Clara Taffoni,Isabelle K Vila,Jane Jardine,Moritz Schussler,Joe Mckellaret al. 2024 Pré-publication, Document de travail hal-04764609v1
Control of polyunsaturated fatty acids desaturation by Sting regulates inflammatory responses Isabelle Vila,Hanane Chamma,Alizée Steer,Clara Taffoni,Line Reinertet al. 2021 Pré-publication, Document de travail hal-03381267v1