Jérôme DESIRE Enseignant Chercheur Université de Poitiers

Publications

Article dans une revue (47)

Evaluation of GlcNAc-Configured Glycomimetics as Pharmacological Chaperones of NAGLU for the Treatment of Mucopolysaccharidosis IIIB Nissrine Ballout,Jérôme Désiré,Angela Johana Espejo-Mojica,Katherin Niño-Traslaviña,Daniel Sandoval-Trujilloet al. Biomolecules, 2026, 16 (2), pp.313. ⟨10.3390/biom16020313⟩ Article dans une revue hal-05523032v1
Introduction of Structural Diversity at the C2 Position of Unsaturated Iminosugars through Palladium‐Catalyzed Cross‐Coupling Reactions Quentin Joachim,Delphine Carry,Mattéo Di Pasquale,Jérôme Marrot,Suzuka Yamamotoet al. European Journal of Organic Chemistry, 2025, 28 (32), ⟨10.1002/ejoc.202500502⟩ Article dans une revue (article de synthèse) hal-05326462v1
Petasis-mediated exo-iminoglycals synthesis from glyconolactams allows access to unprecedented 1-spirocyclopropyl deoxynojirimycin Lilou Chopin,Aurélien Beato,Dylan Yorga,Nicolas Auberger,Jean-Bernard Behret al. Carbohydrate Research, 2025, 560, pp.109765. ⟨10.1016/j.carres.2025.109765⟩ Article dans une revue (article de synthèse) hal-05412880v1
Addition of Lithiated 1,3-Dithiane and Nitronate to Sugar-Derived Imines: Synthesis of Homoiminosugars and Pipecolic Acid Analogues Thanh Van Tran,Jérôme Marrot,Suzuka Yamamoto,Kosuke Yoshimura,Isabelle Gillaizeauet al. Organic Letters, 2025, 27 (20), pp.5068-5073. ⟨10.1021/acs.orglett.5c01061⟩ Article dans une revue hal-05248874v1
Glycosylium Ions in Superacid Mimic the Transition State of Enzyme Reactions Mathilde Armand,Alba Nin-Hill,Ana Ardá,Emanuela Berrino,Jérôme Désiréet al. Journal of the American Chemical Society, 2024, 146 (47), pp.32618-32626. ⟨10.1021/jacs.4c11677⟩ Article dans une revue hal-05326476v1
Glycosylium Ions in Superacid Mimic the Transition State of Enzyme Reactions Mathilde Armand,Alba Nin-Hill,Ana Ardá,Emanuela Berrino,Jérôme Désiréet al. Journal of the American Chemical Society, 2024, 146 (47), pp.32618-32626. ⟨10.1021/jacs.4c11677⟩ Article dans une revue hal-05176253v1
Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors Jérôme Désiré,Zakaria Debbah,David Gueyrard,Jérôme Marrot,Yves Blériotet al. Carbohydrate Research, 2023, 532, pp.108903. ⟨10.1016/j.carres.2023.108903⟩ Article dans une revue hal-04542506v1
Synthesis, conformational analysis and glycosidase inhibition of bicyclic nojirimycin C-glycosides based on an octahydrofuro[3,2-b]pyridine motif Jérôme Désiré,Quentin Foucart,Ana Poveda,Gurvan Gourlaouen,Yuna Shimadateet al. Carbohydrate Research, 2022, 511, pp.108491. ⟨10.1016/j.carres.2021.108491⟩ Article dans une revue hal-04542825v1
Stereoselective Access to Iminosugar C, C-Glycosides from 6-Azidoketopyranoses Zakaria Debbah,Jérôme C. Marrot,Nicolas Auberger,Jérôme Désiré,Yves Blériot Organic Letters, 2022, 24 (25), pp.4542-4546. ⟨10.1021/acs.orglett.2c01560⟩ Article dans une revue hal-03775104v1
Stereoselective Synthesis of 1- C -Diethylphosphonomethyl and -difluoromethyl Iminosugars from Sugar Lactams Thanh Van Tran,Jérôme Désiré,Nicolas Auberger,Yves Blériot Journal of Organic Chemistry, 2022, 87 (11), pp.7581-7585. ⟨10.1021/acs.joc.2c00835⟩ Article dans une revue hal-03953681v1
Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C -alkylation leads to low micromolar HexAB and NagZ inhibitors J. Bouquet,N. Auberger,R. Ashmus,D. King,A. Bordeset al. Organic & Biomolecular Chemistry, 2022, 20 (3), pp.619-629. ⟨10.1039/d1ob02280f⟩ Article dans une revue hal-04526197v1
Sugar-Derived Amidines and Congeners: Structures, Glycosidase Inhibition and Applications Yves Blériot,Nicolas Auberger,Jérôme Désiré Current Medicinal Chemistry, 2022, 29 (7), pp.1271-1292. ⟨10.2174/0929867329666211222164545⟩ Article dans une revue (article de synthèse) hal-04543430v1
Synthesis and chelation study of a fluoroionophore and a glycopeptide based on an aza crown iminosugar structure Alexandra Bordes,Ana Poveda,Nathalie Fontelle,Ana Ardá,Jérôme Guillardet al. Carbohydrate Research, 2021, 501, pp.108258. ⟨10.1016/j.carres.2021.108258⟩ Article dans une revue hal-04336072v1
Insight into the Ferrier rearrangement by combining flash chemistry and superacids Naresh Bhuma,Ludivine Lebedel,Hiroki Yamashita,Yutaka Shimizu,Zahra Abadaet al. Angewandte Chemie International Edition, 2021, 60 (4), pp.2036-2041. ⟨10.1002/anie.202010175⟩ Article dans une revue hal-03007376v1
Iminosugar-C-glycosides work as pharmacological chaperones of NAGLU, a glycosidase involved in MPS IIIB rare disease Sha Zhu,Yerri Jagadeesh,Anh Tuan Tran,Alisdair Boraston,Dominic S Alonziet al. Chemistry - A European Journal, 2021, ⟨10.1002/chem.202101408⟩ Article dans une revue hal-03256952v1
Synthesis, Conformational Analysis, and Complexation Study of an Iminosugar-Aza-Crown, a Sweet Chiral Cyclam Analog Alexandra Bordes,Ana Poveda,Thibault Troadec,Antonio Franconetti,Ana Ardaet al. Organic Letters, 2020, 22 (6), pp.2344-2349. ⟨10.1021/acs.orglett.0c00503⟩ Article dans une revue hal-02504835v1
Synthesis and glycosidase inhibition of conformationally locked DNJ and DMJ derivatives exploiting a 2-oxo- C -allyl iminosugar Quentin Foucart,Yuna Shimadate,Jérôme Marrot,Atsushi Kato,Jérôme Désiréet al. Organic & Biomolecular Chemistry, 2019, 17 (30), pp.7204-7214. ⟨10.1039/c9ob01402k⟩ Article dans une revue hal-04418307v1
Site-Selective Debenzylation of C -Allyl Iminosugars Enables Their Stereocontroled Structure Diversification at the C-2 Position Quentin Foucart,Jérôme Marrot,Jérôme Désiré,Yves Blériot Organic Letters, 2019, 21 (12), pp.4821-4825. ⟨10.1021/acs.orglett.9b01712⟩ Article dans une revue hal-04418300v1
2-Acetamido-2-deoxy- l -iminosugar C -Alkyl and C -Aryl Glycosides: Synthesis and Glycosidase Inhibition Balkis Eddhif,Justin Lange,Nadia Guignard,Yann Batonneau,Jonathan A. Clarhautet al. European Journal of Organic Chemistry, 2018, 2018 (40), pp.5477-5488. ⟨10.1002/ejoc.201800678⟩ Article dans une revue hal-02172201v1
In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay–Sachs disease Atsushi Kato,Izumi Nakagome,Shinpei Nakagawa,Kyoko Kinami,Isao Adachiet al. Organic & Biomolecular Chemistry, 2017, 15 (44), pp.9297-9304. ⟨10.1039/C7OB02281F⟩ Article dans une revue hal-02176719v1
Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics Jaufret Bouquet,Dustin King,G. Vadlamani,G. Benzie,Bogdan Iorgaet al. Organic & Biomolecular Chemistry, 2017, 15 (21), pp.4609-4619. ⟨10.1039/C7OB00838D⟩ Article dans une revue hal-02176734v1
Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance Grishma Vadlamani,Keith A Stubbs,Jerome Desire,Yves Blériot,David J. Vocadloet al. Protein Science, 2017, 26 (6), pp.1161-1170. ⟨10.1002/pro.3166⟩ Article dans une revue hal-02176780v1
HF-Induced Intramolecular C -Arylation and C -Alkylation/Fluorination of 2-Aminoglycopyranoses Nicolas Probst,Amélie Martin,Jérôme Désiré,Agnès Mingot,Jerome Marrotet al. Organic Letters, 2017, 19 (5), pp.1040 - 1043. ⟨10.1021/acs.orglett.7b00003⟩ Article dans une revue hal-01743477v1
Multivalency To Inhibit and Discriminate Hexosaminidases Dimitri Alvarez-Dorta,Dustin King,Thibaut Legigan,Daisuke Ide,Isao Adachiet al. Chemistry - A European Journal, 2017, 23 (38), pp.9022 - 9025. ⟨10.1002/chem.201701756⟩ Article dans une revue hal-01744683v1
Catching elusive glycosyl cations in a condensed phase with HF/SbF₅ superacid A. Martin,A. Arda,J. Désiré,A. Martin-Mingot,N. Probstet al. Nature Chemistry, 2016, ⟨10.1038/nchem.2399⟩ Article dans une revue hal-01505628v1
Synthesis of pyrrolidine-based analogues of 2-acetamidosugars as N-acetyl glucosaminidase inhibitors Anh Tuan Tran,Bo Luo,Jagadeesh Yerri,Nicolas Auberger,Jérôme Désiréet al. Carbohydrate Research, 2015, 409, pp.56-62. ⟨10.1016/j.carres.2015.02.014⟩ Article dans une revue istex hal-01136039v1
Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors. V. Cendret,T. Legigan,A. Martin-Mingot,S. Thibaudeau,I. Adachiet al. Organic & Biomolecular Chemistry, 2015, 13 (43), pp.10734-10744. ⟨10.1039/c5ob01526j⟩ Article dans une revue hal-01500682v1
gamma-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP Y. Jagadeesh,A.T. Tuan,B. Luo,A. Auberger,J. Desireet al. Organic & Biomolecular Chemistry, 2015, 13 pp.3446-3456. ⟨10.1039/c5ob00050e⟩ Article dans une revue hal-01340188v1
γ-Aminoalcohol rearrangement applied to pentahydroxylated azepanes provides pyrrolidines epimeric to homoDMDP Y. Jagadeesh,A. Tran,B. Luo,N. Auberger,J. Désiréet al. Organic & Biomolecular Chemistry, 2015, 13 (11), pp.3446-3456. ⟨10.1039/C5OB00050E⟩ Article dans une revue hal-04543396v1
N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors J. Désiré,M. Mondon,N. Fontelle,S. Nakagawa,Y. Hirokamiet al. Organic & Biomolecular Chemistry, 2014, 12 (44), pp.8977-8996. ⟨10.1039/c4ob00325j⟩ Article dans une revue hal-01311606v1
Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities Fatima El Bahhaj,Jerome Desire,Christophe Blanquart,Nadine Martinet,Vincent Zwicket al. Tetrahedron, 2014, 70 (51 ), pp.9702-9708 ⟨10.1016/j.tet.2014.10.053⟩ Article dans une revue istex hal-01314516v1
Synthesis of 1,2-trans-2-Acetamido-2-deoxyhomoiminosugars Yves Blériot,Anh Tuan Tran,Giuseppe Prencipe,Jagadeesh Yerri,Nicolas Aubergeret al. Organic Letters, 2014, 16 (21 ), pp.5516-5519. ⟨10.1021/ol502929h⟩ Article dans une revue hal-01315627v1
Synthesis of 1,2-cis-Homoiminosugars Derived from GlcNAc and GalNAc Exploiting a β-Amino Alcohol Skeletal Rearrangement Yves Blériot,Nicolas Auberger,Jagadeesh Yerri,Charles Gauthier,Giuseppe Prencipeet al. Organic Letters, 2014, 16 (21 ), pp.5512-5515. ⟨10.1021/ol502926f⟩ Article dans une revue hal-01315083v1
Cyclodextrin-glycerol dimers: synthesis and NMR conformational analysis V. Legros,C. Vanhaverbeke,F. Souard,C. Len,J. Désiré European Journal of Organic Chemistry, 2013, 13, pp.2583-2590. ⟨10.1002/ejoc.201201716⟩ Article dans une revue istex hal-00934169v1
Novel imino sugar α-glucosidase inhibitors as antiviral drugs J.D. Howe,N. Smith,L.J. Marvin,N. Ardes-Guillot,J. Désiréet al. Bioorganic and Medicinal Chemistry, 2013, 21, pp.4831-4838. ⟨10.1016/j.bmc.2013.03.014⟩ Article dans une revue istex hal-00932306v1
Novel imino sugar α-glucosidase inhibitors as antiviral compounds. J. D. Howe,N. Smith,M. J.-R. Lee,N. Ardes-Guisot,B. Vauzeilleset al. Bioorganic and Medicinal Chemistry, 2013, 21 (16), pp.4831-8. ⟨10.1016/j.bmc.2013.03.014⟩ Article dans une revue istex hal-00856804v1
Access to l- and d-Iminosugar C-Glycosides from a d-gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy. Martine Mondon,Nathalie Fontelle,Jérôme Désiré,Frédéric Lecornué,Jérôme Guillardet al. Organic Letters, 2012, 14 (3), pp.870-3. ⟨10.1021/ol203385w⟩ Article dans une revue hal-00669930v1
Synthesis and conformational analysis of bicyclic mimics of alpha- and beta-D-glucopyranosides adopting the biologically relevant 2,5B conformation L. Amorim,Farias Marcelo,J. Désiré,M. Sollogoub,J. Jimenez-Barberoet al. Carbohydrate Research, 2012, 361, pp.219-224. ⟨10.1016/j.carres.2012.07.005⟩ Article dans une revue istex hal-00834859v1
A Peptide Nucleic Acid-Aminosugar Conjugate Targeting Transactivation Response Element of HIV-1 RNA Genome Shows a High Bioavailability in Human Cells and Strongly Inhibits Tat-Mediated Transactivation of HIV-1 Transcription I. Das,J. Désiré,D. Manvar,I. Baussanne,V.N. Pandeyet al. Journal of Medicinal Chemistry, 2012, 55 (13), pp.6021-6032. ⟨10.1021/jm300253q⟩ Article dans une revue hal-00838407v1
Toward the Supramolecular Cyclodextrin Dimers Using Nucleobase Pairs Vanessa Legros,Florian Hamon,Bruno Violeau,Frédéric Turpin,Florence Djedaini-Pilardet al. Synthesis: Journal of Synthetic Organic Chemistry, 2011, 2011 (02), pp.235-242. ⟨10.1055/s-0030-1258354⟩ Article dans une revue hal-02944637v1
Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleotide 3'-disulfides. Béatrice Gerland,Jerome Desire,Jan Balzarini,Jean Luc Decout Bioorganic and Medicinal Chemistry, 2008, pp.6824-6831. ⟨10.1016/j.bmc.2008.05.065⟩ Article dans une revue istex hal-00383176v1
Covalently bonded DNA aptamer chiral stationary phase for the chromatographic resolution of adenosine. J. Ruta,Corinne Ravelet,J. Désiré,Jean Luc Decout,E. Peyrin Analytical and Bioanalytical Chemistry, 2008, 390, pp.1051-1057. ⟨10.1007/s00216-007-1552-0⟩ Article dans une revue istex hal-00383152v1
Mechanism of RNA cleavage catalyzed by sequence specific polyamide nucleic acid-neamine conjugate. B. Chaubey,S. Tripathi,Jerome Desire,I. Baussanne,Jean Luc Decoutet al. Oligonucleotides, 2007, pp.302-313. ⟨10.1089/oli.2007.0085⟩ Article dans une revue hal-00383208v1
Direct preparation of nucleoside vinyl disulfides from 2-(trimethylsilyl)ethyl sulfides, an access to vinylthiols. Jean Luc Decout,J. Désiré,Béatrice Gerland,Michel Lepoivre Organic Letters, 2007, pp.3021-3023 Article dans une revue hal-00382953v1
Neamine dimers targeting the HIV-1 TAR RNA. Jean Luc Decout,J. Désiré,E. Riguet,O. Boden,V. Ludwiget al. Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.4651-4655. ⟨10.1016/j.bmcl.2005.07.082⟩ Article dans une revue istex hal-00123107v1
Neamine dimers targeting the HIV-1 TAR RNA. Emmanuel Riguet,Jerome Desire,Oliver Boden,Verena Ludwig,Michael Göbelet al. Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.4651-4655 Article dans une revue hal-00382910v1
Imino glycals in synthesis : preparation of novel deoxymannojirimycin analogues J. Désiré,M. Shipman SYNLETT, 2001, 8, pp.1332-1334. ⟨10.1055/s-2001-16049⟩ Article dans une revue hal-00123045v1

Communication dans un congrès (1)

Synthesis of 1-C-dithiane and 1-C-nitromethyl iminosugars from sugar lactams Thanh Van Tran,Jérôme Désiré,Nicolas Auberger,Yves Blériot The 29th days of the French Group of Glycosciences (CFG 2024), May 2024, Obernai, France Communication dans un congrès hal-05344140v1

Poster de conférence (2)

Synthesis of functionalizable iminosugar C-glycosides through processing of nitro and dithiane derivatives obtained from readily available sugar lactams Thanh van Tran,Jérôme Désiré,Nicolas Auberger,Yves Blériot Organic Chemistry Days - JCO2025, Oct 2025, Palaiseau (Ecole Polytechnique), France. Poster de conférence hal-05344204v1
2-Acetamido-2-deoxy-D-iminosugar C-glycosides: recent synthetic approaches and perspectives Nicolas Auberger,Thanh van Tran,Quentin Foucart,Jérôme Désiré,Yves Blériot Eurocarb21 - The 21st European Carbohydrate Symposium in Paris, Jul 2023, Paris Maison de la Chimie, France Poster de conférence hal-05575721v1

Chapitre d'ouvrage (1)

One-Step Preparation of Protected N-tert -Butanesulfinyl D-ribo and D-xylo Furanosylamines from Related Sugar Hemiacetals Chloé Cocaud,Cyril Nicolas,Jérôme Désiré,Olivier R Martin Christian Vogel; Paul Murphy. Carbohydrate Chemistry : Proven Synthetic Methods, Volume 4, 4, CRC Press, pp.45-52, 2017, 978-1-4987-2691-7. ⟨10.1201/9781315120300-6⟩ Chapitre d'ouvrage hal-04694840v1

Brevet (2)

Process for the preparation of nucleoside disulfides and thiosulfinates via coupling reaction Jean Luc Decout,Béatrice Gerland,J. Désiré Patent n° : FR 2900151, FR 2907786, CA 2650186, EP 2016088, WO2007122333. 2006 Brevet hal-00383679v1
Preparation of thionucleosides as antiviral and antitumor agents Jean Luc Decout,Béatrice Gerland,J. Désiré,Michel Lepoivre,Jan Balzarini Patent n° : FR 2907786, WO 2008059130. 2006 Brevet hal-00383668v1