Jean-Claude Sirard

Identifiants chercheurs

IdHAL :

jean-claude-sirard

ORCID :

0000-0001-9854-4652

IdRef :

124317901

VIAF :

218456709

ISNI :

0000000359647442

ResearcherID :

B-5932-2011

Publications

Article dans une revue (78)

Neutrophil subsets enhance the efficacy of host-directed therapy in pneumococcal pneumonia Laura Matarazzo,Charlotte Costa,Rémi Porte,Jean-Michel Saliou,Martin Figeacet al. Mucosal Immunology, 2025, 18 (1), pp.257-268. ⟨10.1016/j.mucimm.2024.11.009⟩ Article dans une revue inserm-05340629v1
Impaired K48-polyubiquitination downmodulates mouse norovirus propagation Emmrich Wakeford,Elisabeth Werkmeister,Delphine Cayet,Sabine Poiret,Catherine Danielet al. Frontiers in Cellular and Infection Microbiology, 2025, Frontiers in Cellular and Infection Microbiology, 15, pp.1530166. ⟨10.3389/fcimb.2025.1530166⟩ Article dans une revue hal-05280293v1
Physicochemical stability of a polysorbate-80-containing solvent compounded in the hospital pharmacy and used to reconstitute a biologic for nebulisation Laura Négrier,Marine Roche,Damien Lannoy,Christophe Berneron,Léa Pacqueuet al. European Journal of Hospital Pharmacy, 2025, ejhpharm-2024-004441. ⟨10.1136/ejhpharm-2024-004441⟩ Article dans une revue hal-05500268v1
Flagellin nebulization enhances respiratory immune responses in the porcine model Mara Baldry,Ignacio Caballero,Lisette Ruuls,Delphine Cayet,Yasmine Zeroualet al. iScience, 2025, 28 (12), pp.114218. ⟨10.1016/j.isci.2025.114218⟩ Article dans une revue hal-05390732v1
Physicochemical stability of a polysorbate-80-containing solvent compounded in the hospital pharmacy and used to reconstitute a biologic for nebulisation. Laura Negrier,Marine Roche,Damien Lannoy,C. Berneron,L. Pacqueuet al. European Journal of Hospital Pharmacy, 2025, Eur J Hosp Pharm, ⟨10.1136/ejhpharm-2024-004441⟩ Article dans une revue hal-05043532v1
Topical adjunctive treatment with flagellin augments pulmonary neutrophil responses and reduces bacterial dissemination in multidrug-resistant K. pneumoniae infection Christine van Linge,Robert F.J. Kullberg,Osoul Chouchane,Joris Roelofs,Wil Goessenset al. Frontiers in Immunology, 2024, 15, pp.1450486. ⟨10.3389/fimmu.2024.1450486⟩ Article dans une revue inserm-05340825v1
Triggering Toll-Like Receptor 5 Signaling During Pneumococcal Superinfection Prevents the Selection of Antibiotic Resistance Charlotte Costa,Jean-Claude Sirard,Paddy Gibson,Jan-Willem Veening,Erida Gjiniet al. Journal of Infectious Diseases, 2024, pp.jiae239. ⟨10.1093/infdis/jiae239⟩ Article dans une revue inserm-04605101v1
A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection Xue Liu,Laurye van Maele,Laura Matarazzo,Daphnée Soulard,Vinicius Alves Duarte da Silvaet al. Cell Host & Microbe, 2024, 32 (3), pp.304-314.e8. ⟨10.1016/j.chom.2024.02.002⟩ Article dans une revue inserm-04605118v1
Preventive nasal administration of flagellin restores antimicrobial effect of gentamicin and protects against a multidrug-resistant strain of Pseudomonas aeruginosa Ana Raquel Maia,Adeline Cezard,Delphine Fouquenet,Virginie Vasseur,Benoit Briardet al. Antimicrobial Agents and Chemotherapy, 2024, 68 (5), pp.e01361-23. ⟨10.1128/aac.01361-23⟩ Article dans une revue hal-04683300v1
Targeted delivery of flagellin by nebulization offers optimized respiratory immunity and defense against pneumococcal pneumonia Mara Baldry,Charlotte Costa,Yasmine Zeroual,Delphine Cayet,Jeoffrey Pardessuset al. Antimicrobial Agents and Chemotherapy, 2024, 68 (12), pp.e0086624. ⟨10.1128/aac.00866-24⟩ Article dans une revue inserm-05340634v1
Immunostimulatory Effect of Flagellin on MDR-Klebsiella-Infected Human Airway Epithelial Cells Christine van Linge,Katina Hulme,Hessel Peters-Sengers,Jean-Claude Sirard,Wil Goessenset al. International Journal of Molecular Sciences, 2023, 25 (1), pp.309. ⟨10.3390/ijms25010309⟩ Article dans une revue hal-04462460v1
Amoxicillin treatment of pneumococcal pneumonia impacts bone marrow neutrophil maturation and function. Melanie Mondeme,Yasmine Zeroual,Daphne Soulard,Benjamin Hennart,Delphine Beuryet al. Journal of Leukocyte Biology, 2023, Journal of Leukocyte Biology, 115 (3), pp.463-475. ⟨10.1093/jleuko/qiad125⟩ Article dans une revue hal-04474406v1
Treatment of Bacterial Infections with β-Lactams: Cooperation with Innate Immunity Mélanie Mondemé,Christophe Carnoy,Jean-Claude Sirard,Christelle Faveeuw Infection and Immunity, 2023, 91 (2), pp.e00503-22. ⟨10.1128/iai.00503-22⟩ Article dans une revue (article de synthèse) hal-04238526v1
Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence Vikrant Minhas,Arnau Domenech,Dimitra Synefiaridou,Daniel Straume,Max Brendelet al. PLoS Biology, 2023, 21 (1), pp.e3001990. ⟨10.1371/journal.pbio.3001990⟩ Article dans une revue hal-04462466v1
Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq Liselot Dewachter,Julien Dénéréaz,Xue Liu,Vincent de Bakker,Charlotte Costaet al. eLife, 2022, 11, ⟨10.7554/eLife.75607⟩ Article dans une revue hal-04462473v1
TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium Isabelle Fleurot,Raquel López-Gálvez,Pascal Barbry,Antoine Guillon,Mustapha Si-Taharet al. Journal of Cystic Fibrosis, 2022, 21 (2), pp.e117-e121. ⟨10.1016/j.jcf.2021.08.002⟩ Article dans une revue hal-03556846v1
The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia Robin Michelet,Moreno Ursino,Sandrine Boulet,Sebastian Franck,Fiordiligie Casilaget al. Pharmaceutics, 2021, 13 (5), pp.601. ⟨10.3390/pharmaceutics13050601⟩ Article dans une revue hal-03215662v1
Airway administration of flagellin regulates the inflammatory response to Pseudomonas aeruginosa Raquel López-Gálvez,Isabelle Fleurot,Pablo Chamero,Sascha Trapp,Olivier Michelet al. American Journal of Respiratory Cell and Molecular Biology, 2021, 65 (4), pp.378-389. ⟨10.1165/rcmb.2021-0125OC⟩ Article dans une revue hal-03258174v1
A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice Sebastian Franck,Robin Michelet,Fiordiligie Casilag,Jean Claude Sirard,Sebastian G. Wichaet al. Pharmaceutics, 2021, 13 (4), pp.1-12. ⟨10.3390/pharmaceutics13040469⟩ Article dans une revue hal-03258185v1
The Biosynthetic Monophosphoryl Lipid A Enhances the Therapeutic Outcome of Antibiotic Therapy in Pneumococcal Pneumonia. Fiordiligie Casilag,Laura Matarazzo,Sebastian Franck,Martin Figeac,Robin Micheletet al. ACS Infectious Diseases, 2021, Online ahead of print. ⟨10.1021/acsinfecdis.1c00176⟩ Article dans une revue inserm-03288018v1
The Toll-Like Receptor 5 agonist flagellin prevents Non-typeable Haemophilus influenzae-induced infection in cigarette smoke-exposed mice Magdiel Pérez-Cruz,Bachirou Koné,Rémi Porte,Christophe Carnoy,Julien Tabareauet al. PLoS ONE, 2021, 16 (3), ⟨10.1371/journal.pone.0236216⟩ Article dans une revue hal-03258191v1
mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin I. Ramirez-Moral,X. Yu,J. M. Butler,M. van Weeghel,N. A. Ottoet al. Mucosal Immunology, 2021, 14 (3), pp.594-604. ⟨10.1038/s41385-021-00377-8⟩ Article dans une revue hal-03258194v1
Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection Wanhai Qin,Xanthe Brands,Cornelis Van’t Veer,Alex F. de Vos,Jean Claude Sirardet al. PLoS Pathogens, 2021, 17 (4), ⟨10.1371/journal.ppat.1009491⟩ Article dans une revue hal-03258188v1
Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling Claire Mackowiak,Tiffany Marchiol,Hana Cipcic Paljetak,Louis Fauconnier,Jennifer Palomoet al. ImmunoHorizons , 2021, 5 (5), pp.273-283. ⟨10.4049/immunohorizons.2000095⟩ Article dans une revue hal-03258180v1
Live attenuated Bordetella pertussis vaccine candidate BPZE1 transiently protects against lethal pneumococcal disease in mice Thomas Belcher,Hana Kammoun,Loïc Coutte,Anne-Sophie Debrie,Nathalie Mielcareket al. Vaccine, In press, ⟨10.1016/j.vaccine.2021.01.025⟩ Article dans une revue hal-03372774v1
The GM-CSF released by airway epithelial cells orchestrates the mucosal adjuvant activity of flagellin Aneesh Vijayan,Laurye van Maele,Delphine Fougeron,Delphine Cayet,Jean Claude Sirard Journal of Immunology, 2020, pp.ji2000746 Article dans une revue inserm-02957765v1
Synthetic gene-regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae Robin A. Sorg,Clement Gallay,Laurye van Maele,Jean Claude Sirard,Jan-Willem Veening Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (44), pp.27608-27619. ⟨10.1073/pnas.1920015117⟩ Article dans une revue hal-03258211v1
Recombinant flagellins with deletions in domains D1, D2, and D3: Characterization as novel immunoadjuvants Marina Elizabeth Biedma,Delphine Cayet,Julien Tabareau,Andrés Rossi,Karolina Ivičak-Kocjanet al. Vaccine, 2019, 37 (4), pp.652-663. ⟨10.1016/j.vaccine.2018.12.009⟩ Article dans une revue inserm-02078833v1
Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4 Anne-Sophie Debrie,Nathalie Mielcarek,Sophie Lecher,Xavier Roux,Jean Claude Sirardet al. Journal of Immunology, 2019, pp.ji1901102. ⟨10.4049/jimmunol.1901102⟩ Article dans une revue inserm-02398404v1
A rapid, simple and sensitive liquid chromatography tandem mass spectrometry assay to determine amoxicillin concentrations in biological matrix of little volume Sebastian Franck,Tania Fuhrmann-Selter,Jan Joseph,Robin Michelet,Fiordiligie Casilaget al. Talanta, 2019, 201, pp.253-258. ⟨10.1016/j.talanta.2019.03.098⟩ Article dans une revue istex inserm-02144087v1
Toll-like receptor 5 agonist flagellin reduces influenza A virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir Anne-France Georgel,Delphine Cayet,Andrés Pizzorno,Manuel Rosa-Calatrava,Christophe Pagetet al. Antiviral Research, 2019, 168, pp.28-35. ⟨10.1016/j.antiviral.2019.05.002⟩ Article dans une revue inserm-02144074v1
Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia Laura Matarazzo,Fiordiligie Casilag,Rémi Porte,Frederic Wallet,Delphine Cayetet al. Frontiers in Immunology, 2019, 10, pp.723. ⟨10.3389/fimmu.2019.00723⟩ Article dans une revue inserm-02144080v1
Toll‐like receptor 4 signaling in hematopoietic‐lineage cells contributes to the enhanced activity of the human vaccine adjuvant AS01 Laurye van Maele,Delphine Fougeron,Delphine Cayet,Aurélie Chalon,Diego Piccioliet al. European Journal of Immunology, 2019, 49 (12), pp.2134-2145. ⟨10.1002/eji.201948234⟩ Article dans une revue inserm-02398403v1
Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation Fabien Bastaert,Saadé Kheir,Vinciane Saint-Criq,Bérengère Villeret,Pham My-Chan Danget al. Frontiers in Immunology, 2018, 9, pp.1675. ⟨10.3389/fimmu.2018.01675⟩ Article dans une revue inserm-02078851v1
Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection Ranin Beshara,Valentin Sencio,Daphnée Soulard,Adeline Barthélémy,Josette Fontaineet al. PLoS Pathogens, 2018, 14 (10), pp.e1007360. ⟨10.1371/journal.ppat.1007360⟩ Article dans une revue inserm-02078841v1
Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae Khalil Farhat,Gwennaëlle Bodart,Chantal Charlet-Renard,Christophe Desmet,Michel Moutschenet al. Frontiers in Immunology, 2018, 9, pp.2175. ⟨10.3389/fimmu.2018.02175⟩ Article dans une revue inserm-02078849v1
Compartmentalized Antimicrobial Defenses in Response to Flagellin Aneesh Vijayan,Martin Rumbo,Christophe Carnoy,Jean-Claude Sirard Trends in Microbiology, 2017, 9, pp.143 - 153. ⟨10.1016/j.tim.2017.10.008⟩ Article dans une revue inserm-01671191v1
Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22. Rémi Porte,Laurye van Maele,Natalia Muñoz-Wolf,Benoit Foligné,Laure Dumoutieret al. Infection and Immunity, 2017, 85 (2), pp.e00806-16. ⟨10.1128/IAI.00806-16⟩ Article dans une revue inserm-01529315v1
Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages. Catherine Sabatel,Coraline Radermecker,Laurence Fievez,Genevieve Paulissen,Svetoslav Chakarovet al. Immunity, 2017, 46 (3), pp.457-473. ⟨10.1016/j.immuni.2017.02.016⟩ Article dans une revue inserm-01529380v1
Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model. Carolina Iraporda,David E Romanin,Ana A Bengoa,Agustina J Errea,Delphine Cayetet al. Frontiers in Immunology, 2016, 7, pp.651. ⟨10.3389/fimmu.2016.00651⟩ Article dans une revue inserm-01529366v1
Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion. Natalia Muñoz-Wolf,Analía Rial,Delphine Fougeron,Julien Tabareau,Jean-Claude Sirardet al. Future Microbiology, 2016, 11 (9), pp.1167-77. ⟨10.2217/fmb-2016-0045⟩ Article dans une revue inserm-01529275v1
Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner. Agustina Errea,Delphine Cayet,Philippe Marchetti,Cong Tang,Jerome Kluzaet al. PLoS ONE, 2016, 11 (11), pp.e0163694. ⟨10.1371/journal.pone.0163694⟩ Article dans une revue inserm-01529298v1
Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4+ T cells. Agathe Goubard,Caroline Loïez,Jun Abe,Caroline Fichel,Stéphanie Herweghet al. Infection and Immunity, 2015, 83 (5), pp.2053-64. ⟨10.1128/IAI.02339-14⟩ Article dans une revue inserm-01182906v1
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5 Magdalena Matusiak,Nina van Opdenbosch,Lieselotte Vande Walle,Jean-Claude Sirard,Thirumala-Devi Kannegantiet al. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (5), pp.1541-1546. ⟨10.1073/pnas.1417945112⟩ Article dans une revue inserm-01182904v1
A toll-like receptor 5 agonist improves the efficacy of antibiotics in the treatment of primary and influenza-associated pneumococcal mouse infections. Rémi Porte,Delphine Fougeron,Natalia Muñoz-Wolf,Julien Tabareau,Anne-France Georgelet al. Antimicrobial Agents and Chemotherapy, 2015, 59 (10), pp.6064-6072. ⟨10.1128/AAC.01210-15⟩ Article dans une revue inserm-01182908v1
Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract Delphine Fougeron,Laurye van Maele,Pascal Songhet,Delphine Cayet,David Hotet al. Vaccine, 2015, 33 (29), pp.3331-41. ⟨10.1016/j.vaccine.2015.05.022⟩ Article dans une revue inserm-01182907v1
Airway structural cells regulate TLR5-mediated mucosal adjuvant activity. Laurye van Maele,Delphine Fougeron,Laure Janot,Arnaud Didierlaurent,Delphine Cayetet al. Mucosal Immunology, 2013, epub ahead of print. ⟨10.1038/mi.2013.66⟩ Article dans une revue inserm-00925663v1
In vivo germination of Bacillus anthracis spores during murine cutaneous infection. Jean-Philippe Corre,Alejandro Piris-Gimenez,Marie Moya-Nilges,Gregory Jouvion,Agnes Fouetet al. Journal of Infectious Diseases, 2013, 207 (3), pp.450-7. ⟨10.1093/infdis/jis686⟩ Article dans une revue inserm-00926617v1
Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection. Stoyan Ivanov,Joelle Renneson,Josette Fontaine,Adeline Barthelemy,Christophe Pagetet al. Journal of Virology, 2013, 87 (12), pp.6911-24. ⟨10.1128/JVI.02943-12⟩ Article dans une revue inserm-00926618v1
NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium. Boas Felmy,Pascal Songhet,Emma Marie Caroline Slack,Andreas J. Müller,Marcus Kremeret al. PLoS ONE, 2013, 8 (10), pp.e77204. ⟨10.1371/journal.pone.0077204⟩ Article dans une revue inserm-00925654v1
The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon. Maria L. Knudsen,Daniel X. Johansson,Linda Kostic,Eva K. L. Nordström,Karin Tegerstedtet al. PLoS ONE, 2013, 8 (6), pp.e65964. ⟨10.1371/journal.pone.0065964⟩ Article dans une revue inserm-00925649v1
Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection. Griselda Moreno,Agustina Errea,Laurye van Maele,Roy Roberts,Hélène Légeret al. Microbes and Infection, 2013, 15 (10-11), pp.708-18. ⟨10.1016/j.micinf.2013.06.010⟩ Article dans une revue inserm-00925669v1
Transgenic mouse model harboring the transcriptional fusion ccl20-luciferase as a novel reporter of pro-inflammatory response. Martina Crispo,Laurye van Maele,Julien Tabareau,Delphine Cayet,Agustina Erreaet al. PLoS ONE, 2013, 8 (11), pp.e78447. ⟨10.1371/journal.pone.0078447⟩ Article dans une revue inserm-00925644v1
Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-γ-mediated immunity. Juan M. Marqués,Analía Rial,Natalia Muñoz,Francois-Xavier Pellay,Laurye van Maeleet al. Immunobiology, 2012, 217 (4), pp.420-9. ⟨10.1016/j.imbio.2011.10.012⟩ Article dans une revue istex inserm-00926614v1
Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide. Stoyan Ivanov,Josette Fontaine,Christophe Paget,Elodie Macho Fernandez,Laurye van Maeleet al. Journal of Infectious Diseases, 2012, 206 (5), pp.723-34. ⟨10.1093/infdis/jis413⟩ Article dans une revue inserm-00926616v1
IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality. Laure Dumoutier,Magali de Heusch,Ciriana Orabona,Naoko Satoh-Takayama,Gerard Eberlet al. European Journal of Immunology, 2011, 41 (4), pp.1075-85. ⟨10.1002/eji.201040878⟩ Article dans une revue inserm-00926611v1
The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal salmonella diarrhea. Kathrin Endt,Bärbel Stecher,Samuel Chaffron,Emma Slack,Nicolas Tchitcheket al. PLoS Pathogens, 2010, 6 (9), pp.e1001097. ⟨10.1371/journal.ppat.1001097⟩ Article dans une revue inserm-00520162v1
TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. Laurye van Maele,Christophe Carnoy,Delphine Cayet,Pascal Songhet,Laure Dumoutieret al. Journal of Immunology, 2010, 185 (2), pp.1177-85. ⟨10.4049/jimmunol.1000115⟩ Article dans une revue inserm-00495564v1
Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection. Natalia Munoz,Laurye van Maele,Juan Marqués,Analia Rial,Jean-Claude Sirardet al. Infection and Immunity, 2010, 78 (10), pp.4226-4233. ⟨10.1128/IAI.00224-10⟩ Article dans une revue inserm-00520159v1
The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells Céline Beauvillain,Francesca Meloni,Jean-Claude Sirard,Simon Blanchard,Ulrich Jarryet al. Journal of Hepatology, 2010, 52 (5), pp.644-51. ⟨10.1016/j.jhep.2009.11.031⟩ Article dans une revue inserm-00926610v1
IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium. Pascal Songhet,Manja Barthel,Till A Röhn,Laurye van Maele,Delphine Cayetet al. PLoS ONE, 2010, 5 (11), pp.e13804. ⟨10.1371/journal.pone.0013804⟩ Article dans une revue inserm-00926613v1
Toll-like receptor 5- and lymphotoxin beta receptor-dependent epithelial Ccl20 expression involves the same NF-kappaB binding site but distinct NF-kappaB pathways and dynamics. Jean-Claude Sirard,Arnaud Didierlaurent,Delphine Cayet,Frédéric Sierro,Martin Rumbo Biochimica et Biophysica Acta - Molecular Cell Research, 2009, 1789 (5), pp.386-94. ⟨10.1016/j.bbagrm.2009.03.001⟩ Article dans une revue inserm-00385296v1
Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin. Laure Janot,Jean-Claude Sirard,Thomas Secher,Nicolas Noulin,Lizette Ficket al. European Journal of Immunology, 2009, 39 (6), pp.1587-96. ⟨10.1002/eji.200838907⟩ Article dans une revue inserm-00385299v1
Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity. Clément Nempont,Delphine Cayet,Martin Rumbo,Coralie Bompard,Vincent Villeretet al. Journal of Immunology, 2008, 181 (3), pp.2036-2043. ⟨10.4049/jimmunol.181.3.2036⟩ Article dans une revue inserm-00309796v1
Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection. Arnaud Didierlaurent,John Goulding,Seema Patel,Robert Snelgrove,Lionel Lowet al. Journal of Experimental Medicine, 2008, 205 (2), pp.323-9. ⟨10.1084/jem.20070891⟩ Article dans une revue inserm-00227540v1
Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells. Aizhen Guo,Melissa A. Lasaro,Jean-Claude Sirard,Jean-Pierre Kraehenbuhl,Dieter M. Schifferli Microbiology, 2007, 153 (Pt 4), pp.1059-69. ⟨10.1099/mic.0.2006/000331-0⟩ Article dans une revue inserm-00177727v1
Nod-like receptors: cytosolic watchdogs for immunity against pathogens. Jean-Claude Sirard,Cécile Vignal,Rodrigue Dessein,Mathias Chamaillard PLoS Pathogens, 2007, 3 (12), pp.e152. ⟨10.1371/journal.ppat.0030152⟩ Article dans une revue inserm-00223906v1
A key role of dendritic cells in probiotic functionality. Benoit Foligne,Georgia Zoumpopoulou,Joelle Dewulf,Amena Ben Younes,Fabrice Chareyreet al. PLoS ONE, 2007, 2 (3), pp.e313. ⟨10.1371/journal.pone.0000313⟩ Article dans une revue inserm-00177781v1
Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium. Rachel A. Luu,Komal Gurnani,Renu Dudani,Rajagopal Kammara,Henk van Faassenet al. Journal of Immunology, 2006, 177 (3), pp.1516-1525. ⟨10.4049/jimmunol.177.3.1516⟩ Article dans une revue inserm-00177783v1
Pathogen-specific TLR signaling in mucosa: mutual contribution of microbial TLR agonists and virulence factors. Jean-Claude Sirard,Mariela Bayardo,Arnaud Didierlaurent European Journal of Immunology, 2006, 36, pp.260-3. ⟨10.1002/eji.200535777⟩ Article dans une revue inserm-00000042v1
Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Arnaud Didierlaurent,Brian Brissoni,Dominique Velin,Natalia Aebi,Aubry Tardivelet al. Molecular and Cellular Biology, 2006, 26, pp.735-42. ⟨10.1128/MCB.26.3.735-742.2006⟩ Article dans une revue inserm-00000043v1
Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5. Martin Rumbo,Clément Nempont,Jean-Pierre Kraehenbuhl,Jean-Claude Sirard FEBS Letters, 2006, 580 (12), pp.2976-84. ⟨10.1016/j.febslet.2006.04.036⟩ Article dans une revue inserm-00071278v1
Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Marie Le Borgne,Nathalie Etchart,Anne Goubier,Sergio A. Lira,Jean Claude Sirardet al. Immunity, 2006, 24, pp.191-201. ⟨10.1016/j.immuni.2006.01.005⟩ Article dans une revue inserm-00000041v1
Innate and acquired plasticity of the intestinal immune system. Arnaud Didierlaurent,Michel Simonet,Jean-Claude Sirard Cellular and Molecular Life Sciences, 2005, 62 (12), pp.1285-7. ⟨10.1007/s00018-005-5032-4⟩ Article dans une revue inserm-00000044v1
Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells. Martin Rumbo,Françoise Courjault-Gautier,Frédéric Sierro,Jean-Claude Sirard,Emanuela Felley-Bosco FEBS Journal, 2005, 272 (2), pp.444-53. ⟨10.1111/j.1742-4658.2004.04484.x⟩ Article dans une revue inserm-00000045v1
How the gut links innate and adaptive immunity. Martin Rumbo,Pascale Anderle,Arnaud Didierlaurent,Frédéric Sierro,Nathalie Debardet al. Annals of the New York Academy of Sciences, 2004, 1029, pp.16-21. ⟨10.1196/annals.1309.003⟩ Article dans une revue istex inserm-00223904v1
Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa. Hugo Cruz Ramos,Martin Rumbo,Jean-Claude Sirard Trends in Microbiology, 2004, 12 (11), pp.509-17. ⟨10.1016/j.tim.2004.09.002⟩ Article dans une revue inserm-00000046v1
Interaction of pathogenic bacteria with rabbit appendix M cells: bacterial motility is a key feature in vivo Marta Marchetti,Jean Claude Sirard,Philippe Sansonetti,Eric Pringault,Sophie Kerneis Microbes and Infection, 2004, 6 (6), pp.521-528. ⟨10.1016/j.micinf.2004.02.009⟩ Article dans une revue istex hal-02675770v1