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Jean-François Brière



**Jean-François Brière** (06/06/1971) - CNRS senior research scientist Laboratory **COBRA** (Organic Chemistry Bioorganic Reactivity and Analysis) University of Rouen Normandy, IRCOF building (UMR CNRS 6014, INSA Rouen Normandy) 1, rue Tesnière, 76821 Mont Saint Aignan (France) ▪ *Email:*, *Tel:* +33(0)235522464 ▪ *Website:* ([](, CatCH group) ▪ *ResearcherID:* [Q-8910-2016](; *ORCID:* [0000-0002-1381-4535]( ▪ 66 publications, 6 book chapters, 5 patents • ***1998* Ph.D. in organic chemistry – University of Rouen Normandy - France** (3 years), ▪ HETEROCYCLIC AND SUPRAMOLECULAR CHEMISTRY: “synthesis of an artificial enzyme to activate the amide bond construction” • ***1999* Post-doc in the Netherland** (18 month), ▪ TOTAL SYNTHESIS: “total synthesis towards solanoeclepin A” • ***2001* Post-doc in Belgium** (15 month), ▪ In collaboration with the company Rhodia Silicones at Lyon ▪ CATALYSE: "hydrosilylation catalyzed by Pt-NHC complexes” **independent researcher** BIORELEVANT CHIRAL HETEROCYCLES, ASYMMETRIC SYNTHESIS, (ORGANO)CATALYSIS, NOVEL BUILDING BLOCKS AND REACTIVITY IN ORGANIC SYNTHESIS • ***2002* R&amp;D researcher for pharmaceutical company in France** ▪ *Research center of RHODIA Company (currently Solvay) at Lyon (France).* • ***2002-07* CNRS research scientist CNRS at LCMT laboratory, Univ. Caen Normandy** **▪ Habilitation *in 2007*** ▪ *Phosphorous &amp; Sulfur team, <a name="_Hlk25095197"></a>University of Caen Normandy (France)* ▪ Asymmetric sulfur ylide epoxidation reaction. ▪ Novel chiral sulfur heterocycles and odorant properties • ***2007* Heterocycles team (group CatCH) at COBRA laboratory, Univ. and INSA of Rouen Normandy (France), UMR CNRS 6014** *▪* **Promoted CNRS senior research scientist *in 2017*** ▪ *Group leader of team CatCH (Catalysis, Chirality and Heterocycles)* *▪ Involved in industrial partnerships (2 joint laboratories, platform and Carnot institute I2C)* ▪ Chemistry of biorelevant chiral heterocycles ▪ (Organo)Catalysis and asymmetric synthesis ▪ Domino and multicomponent methodology in sustainable synthesis ▪ Reactivity and useful platform molecules in organic synthesis: (Meldrum’s acid, triazines, isoxazolidin-5-ones: β-amino acid precursors)


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Recent Advances in Catalytic and Technology-Driven Radical Addition to N,N-Disubstituted Iminium Species

Sylvain Oudeyer , Vincent Levacher , Hélène Beucher , Jean-François Brière
Molecules, 2023, 28 (3), pp.1071. ⟨10.3390/molecules28031071⟩
Journal articles hal-03954900v1
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Nickel‐Catalyzed Cyanoalkylation of Ketone Derivatives

Anaïs Coffinet , Vincent Levacher , Isabelle Gillaizeau , Jean-François Brière , Sylvain Oudeyer
Advanced Synthesis and Catalysis, 2023, Advanced Synthesis & Catalysis, 365, pp.156-160. ⟨10.1002/adsc.202201147⟩
Journal articles hal-03922108v1
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An Organocatalytic and Stereoselective Vinylogous Domino Process Towards Thiochromans

Pierre Milbeo , Arthur Lebrêne , Mariia Savchuk , Giang Vo-Thanh , Sylvain Oudeyer
Chemistry - A European Journal, inPress, ⟨10.1002/chem.202301311⟩
Journal articles hal-04102949v1
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Diastereoselective addition of redox active esters to azomethine imines by electrosynthesis

Ludovic Leleu , Thomas Martzel , Arona Fall , Morgane Sanselme , Vincent Levacher
Chemical Communications, 2022, 58, pp.6100-6103. ⟨10.1039/D2CC01795D⟩
Journal articles hal-03659242v1
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Probing N-Alkoxy Effects in Domino Reactions of α-Bromoacetamide Derivatives Towards Functionalized γ-Lactams

Philippe Champetter , Ismail Alahyen , Catherine Taillier , Jean-François Brière , Vincent Dalla
ChemistrySelect, 2022, 7 (38), ⟨10.1002/slct.202203305⟩
Journal articles hal-03808493v1
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Organocatalytic enantioselective synthesis of β-amino sulfonic acid derivatives

Emmanuel Deau , Alexandra Le Foll , Clémence Fouache , Emilie Corrot , Laetitia Bailly
Chemical Communications, 2021, 57, pp.8348 - 8351. ⟨10.1039/D1CC03477D⟩
Journal articles hal-03322399v1
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Amine Directed Palladium Catalyzed C‐H Halogenation of Phenylalanine Derivatives

Alexia Ville , Julien Annibaletto , Sébastien Coufourier , Christophe Hoarau , Rodolphe Tamion
Chemistry - A European Journal, inPress, 27, pp.13961-13965. ⟨10.1002/chem.202102411⟩
Journal articles hal-03322472v1
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The Catalytic Regio- and Stereoselective Synthesis of 1,6-Diazabicyclo[4.3.0]nonane-2,7-diones

Arthur Lebrêne , Thomas Martzel , Laura Gouriou , Morgane Sanselme , Vincent Levacher
Journal of Organic Chemistry, 2021, 86 (13), pp.8600-8609. ⟨10.1021/acs.joc.1c00252⟩
Journal articles hal-03322396v1
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Asymmetric Synthesis of Isoxazol-5-ones and Isoxazolidin-5-ones

Antonio Macchia , Andreas Eitzinger , Jean-François Brière , Mario Waser , Antonio Massa
Synthesis: Journal of Synthetic Organic Chemistry, 2021, 53 (1), pp.107-122. ⟨10.1055/s-0040-1706483⟩
Journal articles hal-03037370v1
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Multicomponent Catalytic Enantioselective Synthesis of Isoxazolidin‐5‐Ones

Julien Annibaletto , Thomas Martzel , Vincent Levacher , Sylvain Oudeyer , Jean-François Brière
Advanced Synthesis and Catalysis, 2021, 363, pp.4447-4451. ⟨10.1002/adsc.202100719⟩
Journal articles hal-03322422v1
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Organocatalysis: A Tool of Choice for the Enantioselective Nucleophilic Dearomatization of Electron-Deficient Six-Membered Ring Azaarenium Salts

Claire Segovia , Pierre-Antoine Nocquet , Vincent Levacher , Jean-François Brière , Sylvain Oudeyer
Catalysts, 2021, 11 (10), pp.1249. ⟨10.3390/catal11101249⟩
Journal articles hal-03426052v1
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Auto Tandem Catalysis: Asymmetric Vinylogous Cycloaddition / Kinetic Resolution Sequence for the Enantioselective Synthesis of Spiro‐Dihydropyranone from Benzylidene Meldrum’s Acid

Martial Toffano , Régis Guillot , Chloee Bournaud , Jean-François Brière , Giang Vo-Thanh
Advanced Synthesis and Catalysis, 2021, 363, pp.4452-4458. ⟨10.1002/adsc.202100559⟩
Journal articles hal-03304167v1
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Alkylidene Meldrum's Acids as Platforms for the Vinylogous Synthesis of Dihydropyranones

Stéphane Wittmann , Thomas Martzel , Cong Thanh Pham Truong , Martial Toffano , Sylvain Oudeyer
Angewandte Chemie International Edition, 2021, 60, pp.11110-11114. ⟨10.1002/anie.202014489⟩
Journal articles hal-03200519v1
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Enantioselective catalytic synthesis of α-aryl-α-SCF 3 -β 2,2 -amino acids

Andreas Eitzinger , Jean-François Brière , Dominique Cahard , Mario Waser
Organic & Biomolecular Chemistry, 2020, 18 (3), pp.405-408. ⟨10.1039/c9ob02666e⟩
Journal articles hal-02442629v1
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Insight in chitosan aerogels derivatives - Application in catalysis

Ronan Le Goff , Olivier Mahé , Ronan Le Coz-Botrel , Sylvie Malo , Jean-Michel Goupil
Reactive and Functional Polymers, 2020, 146, pp.104393. ⟨10.1016/j.reactfunctpolym.2019.104393⟩
Journal articles hal-02376706v1
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Organocatalytic Multicomponent Synthesis of α/β‐Dipeptide Derivatives

Thomas Martzel , Julien Annibaletto , Pierre Millet , Etienne Pair , Morgane Sanselme
Chemistry - A European Journal, 2020, 26, pp.8541. ⟨10.1002/chem.202001214⟩
Journal articles hal-02523950v1
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Base-Assisted Intramolecular C–N Coupling Reaction from NH 2 -Bound Cyclopalladated L -Phenylalanine to Indoline-2-carboxylic Acid

Aurélien Jacquin-Labarre , Sébastien Coufourier , Rodolphe Tamion , Alexandra Le Foll , Vincent Levacher
Organometallics, 2020, 39 (5), pp.767-773. ⟨10.1021/acs.organomet.0c00030⟩
Journal articles hal-02493098v1
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C5‐Disubstituted Meldrum’s Acid Derivatives as Platform for the Organocatalytic Synthesis of C3‐Alkylated Dihydrocoumarins

Thomas Martzel , Julien Annibaletto , Vincent Levacher , Jean-François Brière , Sylvain Oudeyer
Advanced Synthesis and Catalysis, 2019, 361 (5), pp.995-1000. ⟨10.1002/adsc.201801453⟩
Journal articles hal-02197276v1
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N-Alkoxyacrylamides in Domino Reactions: Catalytic and Stereoselective Access to δ-Lactams

Philippe Champetter , Omar Castillo-Aguilera , Catherine Taillier , Jean-François Brière , Vincent Dalla
European Journal of Organic Chemistry, 2019, 47, pp.7703-7710. ⟨10.1002/ejoc.201901528⟩
Journal articles hal-02376720v1
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Organocatalytic aza-Michael Reaction to 3-Vinyl-1,2,4-triazines as a Valuable Bifunctional Platform

Floris Buttard , Clément Berthonneau , Marie-Aude Hiebel , Jean-François Brière , Franck Suzenet
Journal of Organic Chemistry, 2019, 84 (6), pp.3702-3714. ⟨10.1021/acs.joc.9b00141⟩
Journal articles hal-02197289v1
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Heterogeneous-phase Sonogashira cross-coupling reaction on COC surface for the grafting of biomolecules – Application to isatin

Cécile Soulignac , Benedetta Cornelio , Frédérique Brégier , Franck Le Derf , Jean-François Brière
Colloids and Surfaces B: Biointerfaces, 2019, 181, pp.639-647. ⟨10.1016/j.colsurfb.2019.06.001⟩
Journal articles hal-02197292v1
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Enantioselective Catalytic Transformations of Barbituric Acid Derivatives

Claire Segovia , Arthur Lebrêne , Vincent Levacher , Sylvain Oudeyer , Jean-François Brière
Catalysts, 2019, 9 (2), pp.131. ⟨10.3390/catal9020131⟩
Journal articles hal-02197279v1

Organocatalytic Enantioselective Decarboxylative Protonation Reaction of Meldrum's Acid Derivatives under PTC Conditions

Fabien Legros , Thomas Martzel , Jean-François Brière , Sylvain Oudeyer , Vincent Levacher
European Journal of Organic Chemistry, 2018, 2018 (17), pp.1975-1983. ⟨10.1002/ejoc.201800331⟩
Journal articles hal-02024511v1

Construction of Isoxazolidin-5-ones with a Tetrasubstituted Carbon Center: Enantioselective Conjugate Addition Mediated by Phase-Transfer Catalysis

Timothée Cadart , Vincent Levacher , Stéphane Perrio , Jean-François Brière
Advanced Synthesis and Catalysis, 2018, 360 (7), pp.1499-1509. ⟨10.1002/adsc.201800009⟩
Journal articles hal-01830254v1

Sulfinate-Organocatalyzed (3+2) Annulation Reaction of Propargyl or Allenyl Sulfones with Activated Imines

Thomas Martzel , Jean-François Lohier , Annie-Claude Gaumont , Jean-François Brière , Stéphane Perrio
European Journal of Organic Chemistry, 2018, 2018 (36), pp.5069-5073. ⟨10.1002/ejoc.201800749⟩
Journal articles hal-01846976v1

Sulfinate-Organocatalyzed (3+2) Annulation of Allenyl Sulfones with 1,1-Dicyano Olefins in the Presence of a Quaternary Ammonium Phase Transfer Agent

Thomas Martzel , Jean-François Lohier , Annie-Claude Gaumont , Jean-François Brière , Stéphane Perrio
Advanced Synthesis and Catalysis, 2018, 360 (14), pp.2696-2706. ⟨10.1002/adsc.201800466⟩
Journal articles hal-01850385v1

A Unique (3+2) Annulation Reaction between Meldrum's Acid and Nitrones: Mechanistic Insight by ESI-IMS-MS and DFT Studies

N. Lespes , E. Pair , C. Maganga , M. Bretier , Vincent Tognetti
Chemistry - A European Journal, 2018, 24 (16), pp.4086-4093. ⟨10.1002/chem.201705714⟩
Journal articles hal-02024514v1

Organocatalyzed Thia-Michael Addition and Sequential Inverse Electron Demanding Diels-Alder Reaction to 3-Vinyl-1,2,4- triazine Platforms

Clément Berthonneau , F. Buttard , Marie-Aude Hiebel , Franck Suzenet , Jean-François Brière
Advanced Synthesis and Catalysis, 2017, 359 (23), pp.4106-4110. ⟨10.1002/adsc.201700831⟩
Journal articles hal-02046260v1

Domino Aza-Michael-ih-Diels-Alder Reaction to Various 3-Vinyl-1,2,4-triazines: Access to Polysubstituted Tetrahydro-1,6-naphthyridines

Jabrane Jouha , Floris Buttard , Magali Lorion , Clément Berthonneau , Mostafa Khouili
Organic Letters, 2017, 19 (18), pp.4770-4773. ⟨10.1021/acs.orglett.7b02132⟩
Journal articles hal-02046286v1

Unique Reactivity of α-Substituted Electron-Deficient Allenes using Sulfinate Salts as Lewis Base Organocatalysts

Thomas Martzel , Jean-François Lohier , Annie-Claude Gaumont , Jean-François Brière , Stéphane Perrio
Advanced Synthesis and Catalysis, 2017, 359 (1), pp.96-106. ⟨10.1002/adsc.201600929⟩
Journal articles hal-01830252v1

A Meldrum's Acid Based Multicomponent Synthesis of N‐Fmoc‐isoxazolidin‐5‐ones: Entry to N‐Fmoc‐β‐amino Acids

Alexandra Le Foll , Emmanuel Deau , Emilie Corrot , Laurent Bischoff , Vincent Levacher
European Journal of Organic Chemistry, 2017, 2017 (22), pp.3265-3273. ⟨10.1002/ejoc.201700472⟩
Journal articles hal-02046289v1

Catalytic Enantioselective Syntheses of Isoxazolidin-5-ones

J. Annibaletto , Sylvain Oudeyer , Vincent Levacher , Jean-François Brière
Synthesis: Journal of Synthetic Organic Chemistry, 2017, 49 (10), pp.2117-2128. ⟨10.1055/s-0036-1588765⟩
Journal articles hal-02046255v1

Enantioselective Phase-Transfer Catalyzed α-Sulfanylation of Isoxazolidin-5-ones: An Entry to β 2,2 -Amino Acid Derivatives

Timothée Cadart , Clément Berthonneau , Vincent Levacher , Stéphane Perrio , Jean-François Brière
Chemistry - A European Journal, 2016, 22 (43), pp.15261-15264. ⟨10.1002/chem.201603910⟩
Journal articles hal-01830257v1

Meldrum's Acid: A Useful Platform in Asymmetric Organocatalysis

Etienne Pair , Timothée Cadart , Vincent Levacher , Jean-François Brière
ChemCatChem, 2016, 8 (11), pp.1882-1890. ⟨10.1002/cctc.201600247⟩
Journal articles hal-02046231v1

Modified multicomponent Biginelli–Atwal reaction towards a straightforward construction of 5,6-dihydropyrimidin-4-ones

Etienne Pair , Vincent Levacher , Jean-François Brière
RSC Advances, 2015, 5 (57), pp.46267-46271. ⟨10.1039/c5ra08792a⟩
Journal articles hal-01158390v1

Sequential Michael Addition and Enamine-Promoted Inverse Electron Demanding Diels–Alder Reaction upon 3-Vinyl-1,2,4-triazine Platforms

Magali Lorion , Gerald Guillaumet , Jean-François Brière , Franck Suzenet
Organic Letters, 2015, 17 (12), pp.3154-3157. ⟨10.1021/acs.orglett.5b01487⟩
Journal articles hal-01167194v1

Organocatalyzed Multicomponent Synthesis of Isoxazolidin-5-ones

Christophe Berini , Muriel Sebban , Hassan Oulyadi , Morgane Sanselme , Vincent Levacher
Organic Letters, 2015, 17 (21), pp.5408-5411. ⟨10.1021/acs.orglett.5b02755⟩
Journal articles hal-02046141v1

Chitosan: an Upgraded Polysaccharide Waste for Organocatalysis

Olivier Mahé , Jean-François Brière , Isabelle Dez
European Journal of Organic Chemistry, 2015, 2015 (12), pp.2559-2578. ⟨10.1002/ejoc.201403396⟩
Journal articles hal-01148499v1

Progress in Catalytic Asymmetric Protonation

Sylvain Oudeyer , Jean-François Brière , Vincent Levacher
European Journal of Organic Chemistry, 2014, 2014 (28), pp.6103-6119. ⟨10.1002/ejoc.201402213⟩
Journal articles hal-01141335v1

Organocatalysed multicomponent synthesis of pyrazolidinones: Meldrum's acid approach

Etienne Pair , Christophe Berini , Romain Noël , Morgane Sanselme , Vincent Levacher
Chemical Communications, 2014, 50 (71), pp.10218-10221. ⟨10.1039/c4cc04852k⟩
Journal articles hal-01141340v1
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Scalable asymmetric synthesis of a key fragment of Bcl-2/Bcl-xL inhibitors †

Sylvain Laclef , Catherine Taillier , Christine Penloup , Aurélie Viger , Jean-François Brière
RSC Advances, 2014, 4 (75), pp.39817-39821. ⟨10.1039/c4ra07821g⟩
Journal articles hal-01141445v1
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Stereocontrolled lithiation/trapping of chiral 2-alkylideneaziridines: investigation into the role of the aziridine nitrogen stereodynamics

Rosmara Mansueto , Leonardo Degennaro , Jean-François Brière , Karen Griffin , Michael Shipman
Organic & Biomolecular Chemistry, 2014, 12 (42), pp.8505-8511. ⟨10.1039/c4ob01457j⟩
Journal articles hal-01141457v1

Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael

Romain Noël , Vincent Gembus , Vincent Levacher , Jean-François Brière
Organic & Biomolecular Chemistry, 2014, 12 (8), pp.1245-1249. ⟨10.1039/C3OB42406E⟩
Journal articles hal-01141350v1

Organocatalyzed Synthesis of Isoxazolidin-5-ones: The Meldrum's Acid Approach

Svetlana Postikova , Tony Tite , Vincent Levacher , Jean-François Brière
Advanced Synthesis and Catalysis, 2013, 355 (13), pp.2513-2517. ⟨10.1002/adsc.201300465⟩
Journal articles hal-01015420v1

Developments in Meyers' lactamization methodology: en route to bi(hetero)aryl structures with defined axial chirality.

Svetlana Postikova , Mohamad Sabbah , Daniel Wightman , Ich Tuan Nguyen , Morgane Sanselme
Journal of Organic Chemistry, 2013, 78 (16), pp.8191-8197. ⟨10.1021/jo401259w⟩
Journal articles hal-00997427v1

Organocatalysed decarboxylative protonation process from Meldrum's acid: enantioselective synthesis of isoxazolidinones.

Tony Tite , Mohamad Sabbah , Vincent Levacher , Jean-François Brière
Chemical Communications, 2013, 49 (98), pp.11569-11571. ⟨10.1039/c3cc47695b⟩
Journal articles hal-00997428v1

Recent advances in cooperative ion pairing in asymmetric organocatalysis

Jean-François Brière , Sylvain Oudeyer , Vincent Dalla , Vincent Levacher
Chemical Society Reviews, 2012, 41 (5), pp.1696-1707. ⟨10.1039/c1cs15200a⟩
Journal articles hal-00997086v1

Scaffold hopping strategy toward original pyrazolines as selective CB₂ receptor ligands.

Vincent Gembus , Christophe Furman , Régis Millet , Roxane Mansouri , Philippe Chavatte
European Journal of Medicinal Chemistry, 2012, 58, pp.396-404. ⟨10.1016/j.ejmech.2012.10.031⟩
Journal articles hal-00997079v1

Enantioselective synthesis of bio-relevant 3,5-diaryl pyrazolines

Olivier Mahé , Isabelle Dez , Vincent Levacher , Jean-François Brière
Organic & Biomolecular Chemistry, 2012, 10 (19), pp.3946-3954. ⟨10.1039/c2ob25227a⟩
Journal articles hal-00997072v1

Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block.

Vincent Gembus , Solenn Janvier , Jean-Pierre Lecouvé , Lucile Vaysse-Ludot , Jean-François Brière
Organic & Biomolecular Chemistry, 2012, 10 (10), pp.2003-2007. ⟨10.1039/c2ob06762e⟩
Journal articles hal-00997078v1

Highly regio- and diastereoselective anionic [3 + 2] cycloaddition under phase transfer catalytic conditions.

Vincent Gembus , Svetlana Postikova , Vincent Levacher , Jean-François Brière
Journal of Organic Chemistry, 2011, 76 (10), pp.4194-4199. ⟨10.1021/jo2005268⟩
Journal articles hal-00992154v1

Synthesis of pyrazolines by a site isolated resin-bound reagents methodology

Vincent Gembus , Jean-Jacques Bonnet , François Janin , Pierre Bohn , Vincent Levacher
Organic & Biomolecular Chemistry, 2010, 8 (14), pp.3287-3293. ⟨10.1039/c004704j⟩
Journal articles hal-00992140v1

Enantioselective phase-transfer catalysis: synthesis of pyrazolines.

Olivier Mahé , Isabelle Dez , Vincent Levacher , Jean-François Brière
Angewandte Chemie International Edition, 2010, 49 (39), pp.7072-7075. ⟨10.1002/anie.201002485⟩
Journal articles hal-00992138v1

TBD-organocatalysed synthesis of pyrazolines

Olivier Mahé , Denis Frath , Isabelle Dez , Francis Marsais , Vincent Levacher
Organic & Biomolecular Chemistry, 2009, 7 (18), pp.3648-3651. ⟨10.1039/b911577c⟩
Journal articles hal-01915860v1

Synthesis and Evaluation of Enantiopure 6-Thiabicyclo[3.2.1]octanes for Asymmetric Epoxidation of Benzaldehyde

Benjamin Lefranc , Alain Valla , Krishna Ethiraj , Jean-Noel Jaubert , Patrick Metzner
SYNLETT, 2008, 2008 (11), pp.1679-1683. ⟨10.1055/s-2008-1077878⟩
Journal articles hal-01939333v1

Chiral Quaternary Ammonium Salts in Organocatalysis

Sylvain Oudeyer , Vincent Levacher , Jean-François Brière
Maxime R. Vitale; Sylvain Oudeyer; Vincent Levacher; Jean-Francois Briere. Radical and ion-pairing strategies in asymmetric organocatalysis, ISTE Press; Elsevier, pp.87-173, 2017, 978-1-78548-127-7. ⟨10.1016/B978-1-78548-127-7.50002-2⟩
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