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Jean-François Brière

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Laboratoire COBRA (Chimie Organique Bioorganique Réactivité et Analyse) Université de Rouen Normandie (UMR CNRS 6014, INSA Rouen Normandie), Bâtiment IRCOF 1, rue Tesnière, 76821 Mont Saint Aignan - jean-francois.briere@insa-rouen.fr - +33(0)235522464 -ww.lab-cobra.fr/equipes/heterocycles (groupe e-CatCH) ▪ ResearcherID: Q-8910-2016 ▪ ORCID: 0000-0002-1381-4535 **CV: PARCOURS PAR ET POUR LA RECHERCHE** ◦ 1994-98, Docteur en chimie organique (France, 3 ans), Univ. de Rouen Normandie (IRCOF-COBRA) Groupe du Pr. Guy Quéguiner ▪ 1996-97 (1 an) - scientifique du contingent CEA-DAM à Tours ▪ CHIMIE HÉTÉROCYCLIQUE ET SUPRAMOLECULAIRE «synthèse d’une enzyme artificielle» ◦ 1999, Post-doc (Pays-Bas, 18 mois), Univ. d'Amsterdam, groupe du Pr. Henk Hiemstra ▪ SYNTHÈSE TOTALE « total synthesis towards solanoeclepin A » ◦ 2001, Post-doc industriel (Belgique, 15 mois), Univ. catholique de Louvain, groupe du Pr. Istvan E. Markó ▪ Collaboration avec l’entreprise Rhodia Silicones à Lyon ▪ CATALYSE « hydrosilylation catalysées par des complexes Platine/NHC » ◦ 2002, Cadre ingénieur (8 mois), Centre de recherche Rhodia à Lyon ▪ encadrement de techniciens ◦ 2002, CR2 CNRS, LCMT, UniCaen, UMR CNRS 6507 (5 ans) - 2006-CR1, 2007-HDR Groupe du Dr. Patrick Metzner ▪ Chimie des sulfures chiraux (Catalyse et propriétés olfactives) ◦ 2007, (DR2 CNRS en 2017), laboratoire COBRA, Univ. et INSA Rouen Normandie, UMR CNRS 6014 Equipe Hétérocycles dirigée par le Dr. Vincent Levacher ▪ Animateur du groupe e-CatCH (Catalyse, Chiralité, Hétérocycles et électrosynthèse) ▪ Activité en partenariats industriels (participation à 2 LabCom, plateforme contractuelle, Carnot I2C) ◦ 2021, Membre de l’équipe de direction du COBRA – représentant et coanimateur équipe Hétérocycles - 14 thèses (8 collaborations extérieures, 9 via jury (inter)national) -32 post-docs/ATER (11 via jury (inter)national, 15 collab. industrielles), 11 M2-erasmus-IE -Gestion : 6 contrats ANR (dont 1 LabCom, 1 chaire industrielle, 3 cō porteurs), 1 FEDER européen -75 pub., 6 chapitres de livre, 5 brevets ; 29 conf. invitées et séminaires (7+23), 51 Com. Orales, 76 posters -THÈMES : • Hétérocycles chiraux • (Organo)Catalyse et synthèse asymétrique • Processus domino et multicomposés en chimie durable • réactivité et plateformes utiles en synthèse (▪acide de Meldrum ▪triazines ▪isoxazolidin-5-one comme précurseurs d’acides β-aminés) • Thiochimie • Photo- et Électrosynthèse **RECHERCHE PARTENARIALE, ANIMATION ET MANAGEMENT** ◦ Directeur du département synthèse organique de la plateforme C2I-OrgA (2013-17) ▪ Une entrée unique pour nos partenaires industriels et académiques à l’UMR COBRA ▪ Membre Conseil Scientifique ▪ Contrats prestation, entretien annuel d’activité, procédure qualité ◦ Référant DAs synthèse organique du Carnot I2C - Innovation Chimie Carnot (2016-21) ▪ 8 labo. Normands structurés en 5 Domaines d’Activité Stratégiques (DAs) ▪ Membre Comité de pilotage (COPIL) du Carnot I2C ▪ Gestion projets, AAP et communication ◦ Directeur LabCom CNRS « IDECHEM » entre COBRA et Oril Industrie (> 2021) ▪ LabCom signée le 7/2018 pour 5 ans - Membre CS depuis 2020, directeur adjoint T. Poisson ▪ Responsable scientifique collab. recherches en R&D (> 2009), 14 post-docs, 1 doctorant, 5 pub., 5 brevets ◦ Directeur adjoint scientifique de la Chaire Industrielle ANR « COLIBRI » (2023-27, 1,7 M€), porteur Thomas Poisson ◦ Membre nommé du Conseil d’Unité de l’UMR COBRA (2011-16) ◦ Membre élu de la commission restreinte (CCSE, > 2018) ◦ Coordinateur de l’axe hétérocycle du Labex Synorg (> 2019)
Laboratory COBRA (Organic Chemistry Bioorganic Reactivity and Analysis) University of Rouen Normandy (UMR CNRS 6014, INSA Rouen Normandy), IRCOF building 1, rue Tesnière, 76821 Mont Saint Aignan ▪ jean-francois.briere@insa-rouen.fr ▪ +33(0)235522464 ▪ Web : www.lab-cobra.fr/equipes/heterocycles (e-CatCH group) ▪ ResearcherID: Q-8910-2016 ▪ ORCID: 0000-0002-1381-4535 **MY RESEACH PATH AND BACKGROUND** ◦ 1994-98 Ph.D. in organic chemistry (France ,3 years), Normandy Rouen university (IRCOF-COBRA) Group of Pr. Guy Quéguiner ▪ 1996-97 (1 year) – military scientist at CEA-DAM à Tours ▪ HETEROCYCLIC AND SUPRAMOLECULAR CHEMISTRY: “synthesis of an artificial enzyme” ◦ 1999 Post-doc (Netheland, 18 month), University of Amsterdam, IMC, group of Prof. Henk Hiemstra ▪ TOTAL SYNTHESIS: “total synthesis towards solanoeclepin A” ◦ 2001 industrial Post-doc (Belgique, 15 month), Univ. catholique de Louvain, group du Pr. Istvan E. Markó ▪ Collaboration with Rhodia Silicones company at Lyon ▪ CATALYSE: "hydrosilylation catalyzed by Pt-NHC complexes” ◦ 2002, R&D researcher (8 month), Research center of RHODIA (currently Solvay) at Lyon (France) ◦ 2002-07, CNRS research scientist at LCMT laboratory (5 years), Univ. Caen Normandy, UniCaen ▪ Habilitation in 2007 Group of Dr. Patrick Metzner ▪ Chemistry of chiral sulfurs (catalysis and odorant properties) ◦ 2007, (DR2 CNRS en 2017), laboratoire COBRA, Univ. et INSA Rouen Normandie, UMR CNRS 6014 Heterocycles team partnership with Dr. Vincent Levacher ▪ Leader of e-CatCH group (Catalysis, Chirality et Heterocycles and electrosynthesis) ▪ Industrial partnerships activities (Involved in 2 LabCom, exchanges platforms, Carnot I2C) ◦ 2021, Member of the management team of COBRA laboratory ( 2021) – representative of Heterocycles team * 14 PhD (8 external collaborations), 32 PDRA (4 on-going, 15 industrial collaborations), 11 Master-erasmus-Engineer * 75 pub., 6 book chapter, 5 patents; 29 invited conf. and seminars (6+23), 48 oral com., 75 posters * THEME : • Chiral Heterocycles • (Organo)Catalysis and asymmetric synthesis • Domino and multicomponent processes for sustainable chemistry • Reactivity and platform molecules: ▪ Meldrum’s acid ▪ Triazines ▪ Isoxazolidin-5-one as precursors of β-amino acids ▪ SulfaChemistry ▪ Photo- and Electrosynthesis **VALORIZATION AND RESEARCH MANAGEMENT** ◦ Director of organic synthesis department of the technical platform C2I-OrgA (2013-17) ▪ An entry for industrial and academic partnerships at COBRA laboratory ▪ Member of scientific concil ▪ Collaboration Contracts, Annual activity review, quality procedure ◦ Referent DAs organic synthesis of Carnot I2C - Innovation Chimistry Carnot (2016-21) ▪ 8 lab. In Normandy organized in 5 Strategic Activity Domains (DAs) ▪ Member of Steering Committee of Carnot I2C ▪ Projects management, AAP and communication ◦ Responsible of LabCom CNRS « IDECHEM » between COBRA et Oril Industrie (> 2021) ▪ LabCom signed the 7/2018 for 5 years, co-Direction T. Poisson – Member of SC from 2020 ▪ In charge of scientific R&D collaborations (> 2009), 14 PDRA, 5 pub., 5 patents ◦ Deputy scientific director of ANR industrial chair “COLIBRI” (2023-27, 1.7 M€), Director T. Poisson ◦ Member of the Advisor Commission of faculty specialists (CCSE, section 32) – Univ. of Rouen (> 2018) ◦ Member of unit council of COBRA Laboratory (2011-16) ◦ Coordinator of the Heterocycles axis of Labex SynOrg (> 2019)

Publications

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Domino Transformations of 3‐Fluoro‐1,2,4‐Triazine Derivatives towards Spirocyclic and Fused Pyridines

Anthony Lapray , Thomas Martzel , Marie‐aude Hiebel , Sylvain Oudeyer , Franck Suzenet
Advanced Synthesis and Catalysis, 2023, ⟨10.1002/adsc.202301307⟩
Journal articles hal-04373094v1
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Recent Advances in Catalytic and Technology-Driven Radical Addition to N,N-Disubstituted Iminium Species

Sylvain Oudeyer , Vincent Levacher , Hélène Beucher , Jean-François Brière
Molecules, 2023, 28 (3), pp.1071. ⟨10.3390/molecules28031071⟩
Journal articles hal-03954900v1
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An Organocatalytic and Stereoselective Vinylogous Domino Process Towards Thiochromans

Pierre Milbeo , Arthur Lebrêne , Mariia Savchuk , Giang Vo-Thanh , Sylvain Oudeyer
Chemistry - A European Journal, 2023, pp.e202301311. ⟨10.1002/chem.202301311⟩
Journal articles hal-04102949v1
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Synthesis of α-Chloroarylacetic Acid via Electrochemical Carboxylation of α,α-Dichloroarylmethane Derivatives

Corentin Maret , Nicolas David , David Pierrot , Eric Léonel , Vincent Levacher
Molecules, 2023, 28 (18), pp.6704. ⟨10.3390/molecules28186704⟩
Journal articles hal-04238834v1
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Nickel‐Catalyzed Cyanoalkylation of Ketone Derivatives

Anaïs Coffinet , Vincent Levacher , Isabelle Gillaizeau , Jean-François Brière , Sylvain Oudeyer
Advanced Synthesis and Catalysis, 2023, Advanced Synthesis & Catalysis, 365, pp.156-160. ⟨10.1002/adsc.202201147⟩
Journal articles hal-03922108v1
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Probing N-Alkoxy Effects in Domino Reactions of α-Bromoacetamide Derivatives Towards Functionalized γ-Lactams

Philippe Champetter , Ismail Alahyen , Catherine Taillier , Jean-François Brière , Vincent Dalla
ChemistrySelect, 2022, 7 (38), ⟨10.1002/slct.202203305⟩
Journal articles hal-03808493v1
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Organocatalyzed one‐pot sequential deracemization of aromatic ketones bearing a tertiary stereogenic center

Claire Segovia , Jérémy Godemert , Jean-François Brière , Vincent Levacher , Sylvain Oudeyer
Advanced Synthesis and Catalysis, 2022, 364 (22), pp.3794-3799. ⟨10.1002/adsc.202200857⟩
Journal articles hal-03822325v1
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Diastereoselective addition of redox active esters to azomethine imines by electrosynthesis

Ludovic Leleu , Thomas Martzel , Arona Fall , Morgane Sanselme , Vincent Levacher
Chemical Communications, 2022, 58, pp.6100-6103. ⟨10.1039/D2CC01795D⟩
Journal articles hal-03659242v1
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Auto Tandem Catalysis: Asymmetric Vinylogous Cycloaddition / Kinetic Resolution Sequence for the Enantioselective Synthesis of Spiro‐Dihydropyranone from Benzylidene Meldrum’s Acid

Martial Toffano , Régis Guillot , Chloee Bournaud , Jean-François Brière , Giang Vo-Thanh
Advanced Synthesis and Catalysis, 2021, 363, pp.4452-4458. ⟨10.1002/adsc.202100559⟩
Journal articles hal-03304167v1
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Alkylidene Meldrum's Acids as Platforms for the Vinylogous Synthesis of Dihydropyranones

Stéphane Wittmann , Thomas Martzel , Cong Thanh Pham Truong , Martial Toffano , Sylvain Oudeyer
Angewandte Chemie International Edition, 2021, 60, pp.11110-11114. ⟨10.1002/anie.202014489⟩
Journal articles hal-03200519v1
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The Catalytic Regio- and Stereoselective Synthesis of 1,6-Diazabicyclo[4.3.0]nonane-2,7-diones

Arthur Lebrêne , Thomas Martzel , Laura Gouriou , Morgane Sanselme , Vincent Levacher
Journal of Organic Chemistry, 2021, 86 (13), pp.8600-8609. ⟨10.1021/acs.joc.1c00252⟩
Journal articles hal-03322396v1
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Asymmetric Synthesis of Isoxazol-5-ones and Isoxazolidin-5-ones

Antonio Macchia , Andreas Eitzinger , Jean-François Brière , Mario Waser , Antonio Massa
Synthesis: Journal of Synthetic Organic Chemistry, 2021, 53 (1), pp.107-122. ⟨10.1055/s-0040-1706483⟩
Journal articles hal-03037370v1
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Amine Directed Palladium Catalyzed C‐H Halogenation of Phenylalanine Derivatives

Alexia Ville , Julien Annibaletto , Sébastien Coufourier , Christophe Hoarau , Rodolphe Tamion
Chemistry - A European Journal, inPress, 27, pp.13961-13965. ⟨10.1002/chem.202102411⟩
Journal articles hal-03322472v1
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Multicomponent Catalytic Enantioselective Synthesis of Isoxazolidin‐5‐Ones

Julien Annibaletto , Thomas Martzel , Vincent Levacher , Sylvain Oudeyer , Jean-François Brière
Advanced Synthesis and Catalysis, 2021, 363, pp.4447-4451. ⟨10.1002/adsc.202100719⟩
Journal articles hal-03322422v1
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Organocatalysis: A Tool of Choice for the Enantioselective Nucleophilic Dearomatization of Electron-Deficient Six-Membered Ring Azaarenium Salts

Claire Segovia , Pierre-Antoine Nocquet , Vincent Levacher , Jean-François Brière , Sylvain Oudeyer
Catalysts, 2021, 11 (10), pp.1249. ⟨10.3390/catal11101249⟩
Journal articles hal-03426052v1
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Organocatalytic enantioselective synthesis of β-amino sulfonic acid derivatives

Emmanuel Deau , Alexandra Le Foll , Clémence Fouache , Emilie Corrot , Laetitia Bailly
Chemical Communications, 2021, 57, pp.8348 - 8351. ⟨10.1039/D1CC03477D⟩
Journal articles hal-03322399v1
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Organocatalytic Multicomponent Synthesis of α/β‐Dipeptide Derivatives

Thomas Martzel , Julien Annibaletto , Pierre Millet , Etienne Pair , Morgane Sanselme
Chemistry - A European Journal, 2020, 26, pp.8541. ⟨10.1002/chem.202001214⟩
Journal articles hal-02523950v1
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Insight in chitosan aerogels derivatives - Application in catalysis

Ronan Le Goff , Olivier Mahé , Ronan Le Coz-Botrel , Sylvie Malo , Jean-Michel Goupil
Reactive and Functional Polymers, 2020, 146, pp.104393. ⟨10.1016/j.reactfunctpolym.2019.104393⟩
Journal articles hal-02376706v1
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Enantioselective catalytic synthesis of α-aryl-α-SCF 3 -β 2,2 -amino acids

Andreas Eitzinger , Jean-François Brière , Dominique Cahard , Mario Waser
Organic & Biomolecular Chemistry, 2020, 18 (3), pp.405-408. ⟨10.1039/c9ob02666e⟩
Journal articles hal-02442629v1
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Base-Assisted Intramolecular C–N Coupling Reaction from NH 2 -Bound Cyclopalladated L -Phenylalanine to Indoline-2-carboxylic Acid

Aurélien Jacquin-Labarre , Sébastien Coufourier , Rodolphe Tamion , Alexandra Le Foll , Vincent Levacher
Organometallics, 2020, 39 (5), pp.767-773. ⟨10.1021/acs.organomet.0c00030⟩
Journal articles hal-02493098v1
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Organocatalytic aza-Michael Reaction to 3-Vinyl-1,2,4-triazines as a Valuable Bifunctional Platform

Floris Buttard , Clément Berthonneau , Marie-Aude Hiebel , Jean-François Brière , Franck Suzenet
Journal of Organic Chemistry, 2019, 84 (6), pp.3702-3714. ⟨10.1021/acs.joc.9b00141⟩
Journal articles hal-02197289v1
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Heterogeneous-phase Sonogashira cross-coupling reaction on COC surface for the grafting of biomolecules – Application to isatin

Cécile Soulignac , Benedetta Cornelio , Frédérique Brégier , Franck Le Derf , Jean-François Brière
Colloids and Surfaces B: Biointerfaces, 2019, 181, pp.639-647. ⟨10.1016/j.colsurfb.2019.06.001⟩
Journal articles hal-02197292v1
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N-Alkoxyacrylamides in Domino Reactions: Catalytic and Stereoselective Access to δ-Lactams

Philippe Champetter , Omar Castillo-Aguilera , Catherine Taillier , Jean-François Brière , Vincent Dalla
European Journal of Organic Chemistry, 2019, 47, pp.7703-7710. ⟨10.1002/ejoc.201901528⟩
Journal articles hal-02376720v1
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C5‐Disubstituted Meldrum’s Acid Derivatives as Platform for the Organocatalytic Synthesis of C3‐Alkylated Dihydrocoumarins

Thomas Martzel , Julien Annibaletto , Vincent Levacher , Jean-François Brière , Sylvain Oudeyer
Advanced Synthesis and Catalysis, 2019, 361 (5), pp.995-1000. ⟨10.1002/adsc.201801453⟩
Journal articles hal-02197276v1
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Enantioselective Catalytic Transformations of Barbituric Acid Derivatives

Claire Segovia , Arthur Lebrêne , Vincent Levacher , Sylvain Oudeyer , Jean-François Brière
Catalysts, 2019, 9 (2), pp.131. ⟨10.3390/catal9020131⟩
Journal articles hal-02197279v1

Sulfinate-Organocatalyzed (3+2) Annulation Reaction of Propargyl or Allenyl Sulfones with Activated Imines

Thomas Martzel , Jean-François Lohier , Annie-Claude Gaumont , Jean-François Brière , Stéphane Perrio
European Journal of Organic Chemistry, 2018, 2018 (36), pp.5069-5073. ⟨10.1002/ejoc.201800749⟩
Journal articles hal-01846976v1

A Unique (3+2) Annulation Reaction between Meldrum's Acid and Nitrones: Mechanistic Insight by ESI-IMS-MS and DFT Studies

N. Lespes , E. Pair , C. Maganga , M. Bretier , Vincent Tognetti
Chemistry - A European Journal, 2018, 24 (16), pp.4086-4093. ⟨10.1002/chem.201705714⟩
Journal articles hal-02024514v1

Construction of Isoxazolidin-5-ones with a Tetrasubstituted Carbon Center: Enantioselective Conjugate Addition Mediated by Phase-Transfer Catalysis

Timothée Cadart , Vincent Levacher , Stéphane Perrio , Jean-François Brière
Advanced Synthesis and Catalysis, 2018, 360 (7), pp.1499-1509. ⟨10.1002/adsc.201800009⟩
Journal articles hal-01830254v1

Sulfinate-Organocatalyzed (3+2) Annulation of Allenyl Sulfones with 1,1-Dicyano Olefins in the Presence of a Quaternary Ammonium Phase Transfer Agent

Thomas Martzel , Jean-François Lohier , Annie-Claude Gaumont , Jean-François Brière , Stéphane Perrio
Advanced Synthesis and Catalysis, 2018, 360 (14), pp.2696-2706. ⟨10.1002/adsc.201800466⟩
Journal articles hal-01850385v1

Organocatalytic Enantioselective Decarboxylative Protonation Reaction of Meldrum's Acid Derivatives under PTC Conditions

Fabien Legros , Thomas Martzel , Jean-François Brière , Sylvain Oudeyer , Vincent Levacher
European Journal of Organic Chemistry, 2018, 2018 (17), pp.1975-1983. ⟨10.1002/ejoc.201800331⟩
Journal articles hal-02024511v1

A Meldrum's Acid Based Multicomponent Synthesis of N‐Fmoc‐isoxazolidin‐5‐ones: Entry to N‐Fmoc‐β‐amino Acids

Alexandra Le Foll , Emmanuel Deau , Emilie Corrot , Laurent Bischoff , Vincent Levacher
European Journal of Organic Chemistry, 2017, 2017 (22), pp.3265-3273. ⟨10.1002/ejoc.201700472⟩
Journal articles hal-02046289v1

Unique Reactivity of α-Substituted Electron-Deficient Allenes using Sulfinate Salts as Lewis Base Organocatalysts

Thomas Martzel , Jean-François Lohier , Annie-Claude Gaumont , Jean-François Brière , Stéphane Perrio
Advanced Synthesis and Catalysis, 2017, 359 (1), pp.96-106. ⟨10.1002/adsc.201600929⟩
Journal articles hal-01830252v1

Catalytic Enantioselective Syntheses of Isoxazolidin-5-ones

J. Annibaletto , Sylvain Oudeyer , Vincent Levacher , Jean-François Brière
Synthesis: Journal of Synthetic Organic Chemistry, 2017, 49 (10), pp.2117-2128. ⟨10.1055/s-0036-1588765⟩
Journal articles hal-02046255v1

Domino Aza-Michael-ih-Diels-Alder Reaction to Various 3-Vinyl-1,2,4-triazines: Access to Polysubstituted Tetrahydro-1,6-naphthyridines

Jabrane Jouha , Floris Buttard , Magali Lorion , Clément Berthonneau , Mostafa Khouili
Organic Letters, 2017, 19 (18), pp.4770-4773. ⟨10.1021/acs.orglett.7b02132⟩
Journal articles hal-02046286v1

Organocatalyzed Thia-Michael Addition and Sequential Inverse Electron Demanding Diels-Alder Reaction to 3-Vinyl-1,2,4- triazine Platforms

Clément Berthonneau , F. Buttard , Marie-Aude Hiebel , Franck Suzenet , Jean-François Brière
Advanced Synthesis and Catalysis, 2017, 359 (23), pp.4106-4110. ⟨10.1002/adsc.201700831⟩
Journal articles hal-02046260v1

Meldrum's Acid: A Useful Platform in Asymmetric Organocatalysis

Etienne Pair , Timothée Cadart , Vincent Levacher , Jean-François Brière
ChemCatChem, 2016, 8 (11), pp.1882-1890. ⟨10.1002/cctc.201600247⟩
Journal articles hal-02046231v1

Enantioselective Phase-Transfer Catalyzed α-Sulfanylation of Isoxazolidin-5-ones: An Entry to β 2,2 -Amino Acid Derivatives

Timothée Cadart , Clément Berthonneau , Vincent Levacher , Stéphane Perrio , Jean-François Brière
Chemistry - A European Journal, 2016, 22 (43), pp.15261-15264. ⟨10.1002/chem.201603910⟩
Journal articles hal-01830257v1

Organocatalyzed Multicomponent Synthesis of Isoxazolidin-5-ones

Christophe Berini , Muriel Sebban , Hassan Oulyadi , Morgane Sanselme , Vincent Levacher
Organic Letters, 2015, 17 (21), pp.5408-5411. ⟨10.1021/acs.orglett.5b02755⟩
Journal articles hal-02046141v1

Chitosan: an Upgraded Polysaccharide Waste for Organocatalysis

Olivier Mahé , Jean-François Brière , Isabelle Dez
European Journal of Organic Chemistry, 2015, 2015 (12), pp.2559-2578. ⟨10.1002/ejoc.201403396⟩
Journal articles hal-01148499v1

Modified multicomponent Biginelli–Atwal reaction towards a straightforward construction of 5,6-dihydropyrimidin-4-ones

Etienne Pair , Vincent Levacher , Jean-François Brière
RSC Advances, 2015, 5 (57), pp.46267-46271. ⟨10.1039/c5ra08792a⟩
Journal articles hal-01158390v1

Sequential Michael Addition and Enamine-Promoted Inverse Electron Demanding Diels–Alder Reaction upon 3-Vinyl-1,2,4-triazine Platforms

Magali Lorion , Gerald Guillaumet , Jean-François Brière , Franck Suzenet
Organic Letters, 2015, 17 (12), pp.3154-3157. ⟨10.1021/acs.orglett.5b01487⟩
Journal articles hal-01167194v1
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Scalable asymmetric synthesis of a key fragment of Bcl-2/Bcl-xL inhibitors †

Sylvain Laclef , Catherine Taillier , Christine Penloup , Aurélie Viger , Jean-François Brière
RSC Advances, 2014, 4 (75), pp.39817-39821. ⟨10.1039/c4ra07821g⟩
Journal articles hal-01141445v1
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Stereocontrolled lithiation/trapping of chiral 2-alkylideneaziridines: investigation into the role of the aziridine nitrogen stereodynamics

Rosmara Mansueto , Leonardo Degennaro , Jean-François Brière , Karen Griffin , Michael Shipman
Organic & Biomolecular Chemistry, 2014, 12 (42), pp.8505-8511. ⟨10.1039/c4ob01457j⟩
Journal articles hal-01141457v1

Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael

Romain Noël , Vincent Gembus , Vincent Levacher , Jean-François Brière
Organic & Biomolecular Chemistry, 2014, 12 (8), pp.1245-1249. ⟨10.1039/C3OB42406E⟩
Journal articles hal-01141350v1

Progress in Catalytic Asymmetric Protonation

Sylvain Oudeyer , Jean-François Brière , Vincent Levacher
European Journal of Organic Chemistry, 2014, 2014 (28), pp.6103-6119. ⟨10.1002/ejoc.201402213⟩
Journal articles hal-01141335v1

Organocatalysed multicomponent synthesis of pyrazolidinones: Meldrum's acid approach

Etienne Pair , Christophe Berini , Romain Noël , Morgane Sanselme , Vincent Levacher
Chemical Communications, 2014, 50 (71), pp.10218-10221. ⟨10.1039/c4cc04852k⟩
Journal articles hal-01141340v1

Organocatalysed decarboxylative protonation process from Meldrum's acid: enantioselective synthesis of isoxazolidinones.

Tony Tite , Mohamad Sabbah , Vincent Levacher , Jean-François Brière
Chemical Communications, 2013, 49 (98), pp.11569-11571. ⟨10.1039/c3cc47695b⟩
Journal articles hal-00997428v1

Organocatalyzed Synthesis of Isoxazolidin-5-ones: The Meldrum's Acid Approach

Svetlana Postikova , Tony Tite , Vincent Levacher , Jean-François Brière
Advanced Synthesis and Catalysis, 2013, 355 (13), pp.2513-2517. ⟨10.1002/adsc.201300465⟩
Journal articles hal-01015420v1

Developments in Meyers' lactamization methodology: en route to bi(hetero)aryl structures with defined axial chirality.

Svetlana Postikova , Mohamad Sabbah , Daniel Wightman , Ich Tuan Nguyen , Morgane Sanselme
Journal of Organic Chemistry, 2013, 78 (16), pp.8191-8197. ⟨10.1021/jo401259w⟩
Journal articles hal-00997427v1

Scaffold hopping strategy toward original pyrazolines as selective CB₂ receptor ligands.

Vincent Gembus , Christophe Furman , Régis Millet , Roxane Mansouri , Philippe Chavatte
European Journal of Medicinal Chemistry, 2012, 58, pp.396-404. ⟨10.1016/j.ejmech.2012.10.031⟩
Journal articles hal-00997079v1

Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block.

Vincent Gembus , Solenn Janvier , Jean-Pierre Lecouvé , Lucile Vaysse-Ludot , Jean-François Brière
Organic & Biomolecular Chemistry, 2012, 10 (10), pp.2003-2007. ⟨10.1039/c2ob06762e⟩
Journal articles hal-00997078v1

Enantioselective synthesis of bio-relevant 3,5-diaryl pyrazolines

Olivier Mahé , Isabelle Dez , Vincent Levacher , Jean-François Brière
Organic & Biomolecular Chemistry, 2012, 10 (19), pp.3946-3954. ⟨10.1039/c2ob25227a⟩
Journal articles hal-00997072v1

Recent advances in cooperative ion pairing in asymmetric organocatalysis

Jean-François Brière , Sylvain Oudeyer , Vincent Dalla , Vincent Levacher
Chemical Society Reviews, 2012, 41 (5), pp.1696-1707. ⟨10.1039/c1cs15200a⟩
Journal articles hal-00997086v1

Highly regio- and diastereoselective anionic [3 + 2] cycloaddition under phase transfer catalytic conditions.

Vincent Gembus , Svetlana Postikova , Vincent Levacher , Jean-François Brière
Journal of Organic Chemistry, 2011, 76 (10), pp.4194-4199. ⟨10.1021/jo2005268⟩
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Synthesis of pyrazolines by a site isolated resin-bound reagents methodology

Vincent Gembus , Jean-Jacques Bonnet , François Janin , Pierre Bohn , Vincent Levacher
Organic & Biomolecular Chemistry, 2010, 8 (14), pp.3287-3293. ⟨10.1039/c004704j⟩
Journal articles hal-00992140v1

Enantioselective phase-transfer catalysis: synthesis of pyrazolines.

Olivier Mahé , Isabelle Dez , Vincent Levacher , Jean-François Brière
Angewandte Chemie International Edition, 2010, 49 (39), pp.7072-7075. ⟨10.1002/anie.201002485⟩
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TBD-organocatalysed synthesis of pyrazolines

Olivier Mahé , Denis Frath , Isabelle Dez , Francis Marsais , Vincent Levacher
Organic & Biomolecular Chemistry, 2009, 7 (18), pp.3648-3651. ⟨10.1039/b911577c⟩
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Synthesis and Evaluation of Enantiopure 6-Thiabicyclo[3.2.1]octanes for Asymmetric Epoxidation of Benzaldehyde

Benjamin Lefranc , Alain Valla , Krishna Ethiraj , Jean-Noel Jaubert , Patrick Metzner
SYNLETT, 2008, 2008 (11), pp.1679-1683. ⟨10.1055/s-2008-1077878⟩
Journal articles hal-01939333v1

Chiral Quaternary Ammonium Salts in Organocatalysis

Sylvain Oudeyer , Vincent Levacher , Jean-François Brière
Maxime R. Vitale; Sylvain Oudeyer; Vincent Levacher; Jean-Francois Briere. Radical and ion-pairing strategies in asymmetric organocatalysis, ISTE Press; Elsevier, pp.87-173, 2017, 978-1-78548-127-7. ⟨10.1016/B978-1-78548-127-7.50002-2⟩
Book sections hal-02024983v1