jean-marc Brondello

Identifiants chercheurs

IdHAL :

jean-marc-brondello

ORCID :

0000-0001-5991-3945

IdRef :

169662284

ResearcherID :

https://publons.com/researcher/1745930/jean-marc-brondello/

Présentation

Tissue accumulation of p16INK4A-positive senescent cells is associated with age-related disorders, such as osteoarthritis (OA). Indeed, these cell-cycle arrested cells affect tissue function and homestasis through cell-to-cell juxtacrine and paracrine specific mechanisms. Using in vivo transgenic murine models for senescence detection and depletion altogether with in vitro 2D and 3D culture conditions for osteoarticular cells, our group aims at:

identifying senescent articular joint cells that drive tissue degeneration

developing strategies to eliminate such cells in vitro and in vivo

restoring joint functions in elderly to delay prosthetic surgery

Publications

Article dans une revue (29)

A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging Charlène Iltis,Iryna Moskalevska,Antoine Debiesse,Laetitia Seguin,Christina Fissounet al. Nature Aging, 2025, 5, pp.219-236. ⟨10.1038/s43587-024-00776-z⟩ Article dans une revue hal-04949697v3
Furan fatty acids supplementation in obese mice reverses hepatic steatosis and protects against cartilage degradation Mathys Chaslin,Georges Maroun,Erwann Durand,Béatrice Bonafos,Said Assouet al. Biomedicine and Pharmacotherapy, 2025, 187, 13p. ⟨10.1016/j.biopha.2025.118072⟩ Article dans une revue hal-05051861v1
Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis Damien Veret,Gautier Tejedor,Esther Perez,Alison Chomette,Maylis Farnoet al. Stem Cell Research and Therapy, 2025, 16 (1), pp.9. ⟨10.1186/s13287-024-04090-8⟩ Article dans une revue hal-04948767v1
Senescence-regulatory factors as novel circulating biomarkers and therapeutic targets in regenerative medicine for osteoarthritis Georges Maroun,Christina Fissoun,Marina Villaverde,Jean-Marc Brondello,Yves-Marie Pers Joint Bone Spine, 2024, 91 (2), pp.105640. ⟨10.1016/j.jbspin.2023.105640⟩ Article dans une revue hal-04948778v1
Senescence-Driven Inflammatory and Trophic Microenvironment Imprints Mesenchymal Stromal/Stem Cells in Osteoarthritic Patients Giuseppe Fusi,Michael Constantinides,Christina Fissoun,Lydiane Pichard,Yves-Marie Perset al. Biomedicines, 2023, 11 (7), pp.1994. ⟨10.3390/biomedicines11071994⟩ Article dans une revue hal-04949712v1
Osteoarthritis in time for senotherapeutics Damien Veret,Christian Jorgensen,Jean-Marc Brondello Joint Bone Spine, 2021, 88 (2), pp.105084. ⟨10.1016/j.jbspin.2020.105084⟩ Article dans une revue hal-03163864v1
Influence of Glucocorticoids on Cellular Senescence Hallmarks in Osteoarthritic Fibroblast-like Synoviocytes Olivier Malaise,Geneviève Paulissen,Céline Deroyer,Federica Ciregia,Christophe Pouletet al. Journal of Clinical Medicine, 2021, 10 (22), pp.5331. ⟨10.3390/jcm10225331⟩ Article dans une revue hal-04958639v1
Establishment of a collection of human pluripotent stem cell lines (iPSC) from mesenchymal stem cells (MSC) from three healthy elderly donors Lydiane Pichard,Jean-Marc Brondello,Fabienne Becker,Romain Desprat,Frédéric de Ceunincket al. Stem Cell Research, 2021, 53, pp.102297. ⟨10.1016/j.scr.2021.102297⟩ Article dans une revue hal-03664523v1
Generation of human pluripotent stem cell lines (iPSCs) from mesenchymal stem cells (MSCs) from three elderly patients with osteoarthritis Lydiane Pichard,Jean-Marc Brondello,Fabienne Becker,Romain Desprat,Frédéric de Ceunincket al. Stem Cell Research, 2020, 44, pp.101721. ⟨10.1016/j.scr.2020.101721⟩ Article dans une revue hal-02961555v1
Sénothérapies Damien Veret,Jean-Marc Brondello Médecine/Sciences, 2020, 36 (12), pp.1135-1142. ⟨10.1051/medsci/2020220⟩ Article dans une revue hal-03049534v1
Taking in consideration the bystander effects of articular senescence Jean-Marc Brondello,Yves-Marie Pers Annals of translational medicine, 2019, 7 (S8), pp.S386-S386. ⟨10.21037/atm.2019.12.128⟩ Article dans une revue hal-04947712v1
Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases Yassin Tachikart,Olivier Malaise,Marcus Mumme,Christian Jorgensen,Jean-Marc Brondello Biochemical Pharmacology, 2019, 165, pp.126-133. ⟨10.1016/j.bcp.2019.03.017⟩ Article dans une revue hal-02877478v1
Where to Stand with Stromal Cells and Chronic Synovitis in Rheumatoid Arthritis? Jean-Marc Brondello,Farida Djouad,Christian Jorgensen Cells, 2019, 8 (10), pp.1257. ⟨10.3390/cells8101257⟩ Article dans une revue hal-02555388v1
Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer Patricia Luz-Crawford,Javier Hernandez,Farida Djouad,Noymar Luque-Campos,Andrès Caicedoet al. Stem Cell Research and Therapy, 2019, 10 (1), pp.232. ⟨10.1186/s13287-019-1307-9⟩ Article dans une revue inserm-02376241v1
Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development Olivier Malaise,Yassin Tachikart,Michael Constantinides,Marcus Mumme,Rosanna Ferreira-Lopezet al. Aging, 2019, 11 (20), pp.9128-9146. ⟨10.18632/aging.102379⟩ Article dans une revue hal-02551968v1
Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis. Paul Chuchana,Anne-Laure Mausset-Bonnefont,Marc Mathieu,Francisco Espinoza,Marisa Teigellet al. Aging, 2018, 10 (6), pp.1442-1453. ⟨10.18632/aging.101481⟩ Article dans une revue hal-01834060v1
Cibler les cellules sénescentes : Une révolution dans le traitement des pathologies ostéo-articulaires Yassin Tachikart,Olivier Malaise,Michael Constantinides,Christian Jorgensen,Jean-Marc Brondello Médecine/Sciences, 2018, Les Cahiers de Myologie, 34 (6-7), pp.547 - 553. ⟨10.1051/medsci/20183406014⟩ Article dans une revue hal-03179760v1
Senolytic treatments applied to osteoarthritis: a step towards the end of orthopedic surgery? Olivier Malaise,Yassin Tachikart,Jean-Marc Brondello AME Medical Journal, 2017, 2, pp.161 - 161. ⟨10.21037/amj.2017.10.01⟩ Article dans une revue hal-01838428v1
Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy Marie-Luce Vignais,Andrès Caicedo,Jean-Marc Brondello,Christian Jorgensen Stem Cells International, 2017, 2017, pp.6917941. ⟨10.1155/2017/6917941⟩ Article dans une revue hal-01759757v1
Cellular senescence impact on immune cell fate and function Rita Vicente,Anne-Laure Mausset-Bonnefont,Christian Jorgensen,Pascale Louis-Plence,Jean-Marc Brondello Aging Cell, 2016, 15 (3), pp.400 - 406. ⟨10.1111/acel.12455⟩ Article dans une revue hal-01834241v1
MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function Andrès Caicedo,Vanessa Fritz,Jean-Marc Brondello,Mickaël Ayala,Indira Dennemontet al. Scientific Reports, 2015, 5 (1), ⟨10.1038/srep09073⟩ Article dans une revue hal-01834600v1
FOXO3A Regulation by miRNA-29a Controls Chondrogenic Differentiation of Mesenchymal Stem Cells and Cartilage Formation David Guérit,Jean-Marc Brondello,Paul Chuchana,Didier Philipot,Karine Toupetet al. Stem Cells and Development, 2014, 23 (11), pp.1195 - 1205. ⟨10.1089/scd.2013.0463⟩ Article dans une revue hal-01836483v1
p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodelling in osteoarthritis. Didier Philipot,David Guérit,Daniela Platano,Paul Chuchana,Eleonora Olivottoet al. Arthritis Research and Therapy, 2014, 16 (1), pp.R58. ⟨10.1186/ar4494⟩ Article dans une revue inserm-00983071v1
Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage J. Basbous,Dora Knani,Nathalie Bonneaud,Dominique Giorgi,Jean-Marc Brondelloet al. Cell Cycle, 2012, 11 (12), pp.2380-9012. ⟨10.4161/cc.20858⟩ Article dans une revue hal-00705749v1
Cellular Senescence is a Common Characteristic Shared by Preneoplasic and Osteo-Arthritic Tissue~!2009-12-06~!2010-01-18~!2010-02-11~! Jean-Marc Brondello,Didier Philipot,Farida Djouad,Christian Jorgensen,Danièle Noel The Open Rheumatology Journal, 2010, 4 (1), pp.10-14. ⟨10.2174/1874312901004010010⟩ Article dans une revue hal-05000154v1
Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy. Claire Vinatier,Carine Bouffi,Christophe Merceron,Jan Gordeladze,Jean-Marc Brondelloet al. Current Stem Cell Research & Therapy, 2009, 4 (4), pp.318-29 Article dans une revue inserm-00423696v1
Concerted stimuli regulating osteo-chondral differentiation from stem cells: phenotype acquisition regulated by microRNAs Jan Gordeladze,Farida Djouad,Jean-Marc Brondello,D. Noel,Isabelle Duroux-Richardet al. Acta Pharmacologica Sinica, 2009, 30 (10), pp.1369-1384. ⟨10.1038/aps.2009.143⟩ Article dans une revue hal-04989608v1
Linking PCNA-dependent replication and ATR by human Claspin. Jean-Marc Brondello,Bernard Ducommun,Anne Fernandez,Ned J. Lamb Biochemical and Biophysical Research Communications, 2007, 354 (4), pp.1028-33. ⟨10.1016/j.bbrc.2007.01.091⟩ Article dans une revue inserm-00147047v1
DNA damage checkpoint kinase Chk2 triggers replicative senescence Véronique Gire,Pierre Roux,David Wynford-Thomas,Jean-Marc Brondello,Vjekoslav Dulic EMBO Journal, 2004, 23 (13), pp.2554-2563. ⟨10.1038/sj.emboj.7600259⟩ Article dans une revue hal-03763012v1

Brevet (1)

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF OSTEOARTHRITIS Jean-Marc Brondello France, Patent n° : EP22306604. 2022 Brevet hal-04947755v1