Jean-Michel Escoffre Inserm Senior Research Scientist (CRHC, HDR)

Identifiants chercheurs

IdHAL :

jean-michel-escoffre

ORCID :

0000-0003-1041-6950

ResearcherID :

http://www.researcherid.com/rid/P-5606-2014

Présentation

Jean-Michel Escoffre earned his M.Sc. degrees in Vectorology, Gene Therapy, Vaccinology and in Structure/Function in Macromolecules and Living Processes in 2005 and 2006 respectively, at the University Paul-Sabatier (Toulouse, France). He obtained his Ph.D. degrees in Cell Biophysics in 2010 at the Institute of Pharmacology and Structural Biology (IPBS/CNRS, UMR 5089) and University Paul-Sabatier. During his PhD fellowship, he investigated the molecular and cellular mechanisms of gene electrotransfer. For his first post-doctoral fellowship, he joined the Institute of Imaging and Brain of the French Institute for Health and Medical Science (Inserm, UMR 930) in Tours, France (2010-2013). He worked in the fields of gene and drug delivery using microbubble-assisted ultrasound. Then, he joined the Imaging Division at UMC Utrecht, The Netherlands. His main research interest was the development of HIFU-mediated anticancer immunotherapy (2013-2015). He is currently pursuing his research as Inserm Senior Researcher at the Institute of Imaging and Brain of the French Institute for Health and Medical Science (Inserm, University of Tours) in Tours, France. His main research interest lie in the fields of biodrug delivery using ultrasound-guided therapeutic ultrasound. Jean-Michel Escoffre is also expert in Diagnostic Tools, Therapies and Public Health for many national, European and international public and private agencies.

Publications

Article dans une revue (81)

Therapeutic efficacy of in-vivo IL-12 plasmid delivery using microbubble-assisted ultrasound in a B16F10 mouse melanoma model: A proof of concept Edward Oujagir,Coralie Mousset,Marie Roy,Yanis Ramdani,Valérie Schubnelet al. International Journal of Pharmaceutics, 2026, 688, pp.126446. ⟨10.1016/j.ijpharm.2025.126446⟩ Article dans une revue hal-05393881v1
Microbubbles for Acoustically Mediated Drug Delivery to the Inner Ear Charlotte Jeanneau,Fabrice Micaletti,Damien Fouan,Valérie Schubnel,Cédric Chauvierreet al. Molecular Pharmaceutics, 2026, 23 (3), pp.1419-1433. ⟨10.1021/acs.molpharmaceut.5c01397⟩ Article dans une revue inserm-05492017v1
Decoding Cerebrospinal Fluid: Integrative Metabolomics Across Multiple Platforms Antoine Presset,Sylvie Bodard,Antoine Lefèvre,Edward Oujagir,Camille Dupuyet al. Methods and Protocols, 2026, 9 (1), pp.8. ⟨10.3390/mps9010008⟩ Article dans une revue inserm-05448355v1
Numerical modeling of ultrasound propagation in the inner ear for sonoporation-mediated drug delivery Fabrice Micaletti,David Bakhos,Jean-Michel Escoffre,Dapeng Li,Ayache Bouakazet al. Applied Physics Letters, 2025, 126 (2), pp.024101. ⟨10.1063/5.0239956⟩ Article dans une revue inserm-04891735v1
Intracerebral drug delivery using microbubble/nanodroplet-assisted ultrasound to address neurodegenerative diseases Karen Ea,Nicolas Taulier,Christiane Contino-Pépin,Wladimir Urbach,Stéphane Desgrangeset al. Journal of Clinical and Translational Research, 2025, pp.00061. ⟨10.36922/jctr.24.00061⟩ Article dans une revue hal-04974610v1
Metabolomic profile of cerebral tissue after acoustically-mediated blood-brain barrier opening in a healthy rat model: a focus on the contralateral side Antoine Presset,Sylvie Bodard,Antoine Lefèvre,Anaïs Millet,Edward Oujagiret al. Frontiers in Molecular Neuroscience, 2024, 17, pp.1383963. ⟨10.3389/fnmol.2024.1383963⟩ Article dans une revue inserm-04795005v1
Delivery of Anticancer Drugs Using Microbubble-Assisted Ultrasound in a 3D Spheroid Model Marie Roy,Corentin Alix,Julien Burlaud-Gaillard,Damien Fouan,William Raoulet al. Molecular Pharmaceutics, 2024, Online ahead of print. ⟨10.1021/acs.molpharmaceut.3c00921⟩ Article dans une revue inserm-04374054v1
Enhanced macromolecular substance extravasation through the blood-brain barrier via acoustic bubble-cell interactions Jifan Chen,Jean-Michel Escoffre,Oliver Romito,Tarik Iazourene,Antoine Pressetet al. Ultrasonics Sonochemistry, 2024, 103, pp.106768. ⟨10.1016/j.ultsonch.2024.106768⟩ Article dans une revue inserm-04425434v1
Microbubble-assisted ultrasound for inner ear drug delivery Fabrice Micaletti,Jean-Michel Escoffre,Sandrine Kerneis,Ayache Bouakaz,John Galvinet al. Advanced Drug Delivery Reviews, 2024, 204, pp.115145. ⟨10.1016/j.addr.2023.115145⟩ Article dans une revue inserm-04333190v1
Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review Marie Roy,Corentin Alix,Ayache Bouakaz,Sophie Serrière,Jean-Michel Escoffre Pharmaceutics, 2023, 15 (3), pp.806. ⟨10.3390/pharmaceutics15030806⟩ Article dans une revue inserm-04032858v1
Sonoporation of the Round Window Membrane on a Sheep Model: A Safety Study Sandrine Kerneis,Jean-Michel Escoffre,John J Galvin,Ayache Bouakaz,Antoine Pressetet al. Pharmaceutics, 2023, 15 (2), pp.442. ⟨10.3390/pharmaceutics15020442⟩ Article dans une revue inserm-03964324v1
First Metabolomic Signature of Blood-Brain Barrier Opening Induced by Microbubble-Assisted Ultrasound Antoine Presset,Sylvie Bodard,Antoine Lefèvre,Anaïs Millet,Edward Oujagiret al. Frontiers in Molecular Neuroscience, 2022, 15, pp.888318. ⟨10.3389/fnmol.2022.888318⟩ Article dans une revue inserm-03707049v1
Microbubble-assisted ultrasound for imaging and therapy of melanoma skin cancer: A systematic review François Avry,Coralie Mousset,Edward Oujagir,Ayache Bouakaz,Valérie Gouilleux-Gruartet al. Ultrasound in Medicine & Biology, In press, 48 (11), pp.2174-2198. ⟨10.1016/j.ultrasmedbio.2022.06.021⟩ Article dans une revue inserm-03707096v1
Ultrasound Neurostimulation in Mice: Impact of Ultrasound Settings and Beam Properties Jean-Michel Escoffre,Ayache Bouakaz,Tarik Iazourène,Hanaa Malloul,Edward Oujagiret al. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2022, Ahead of print Article dans une revue inserm-03528841v1
Delivery of anti-cancer drugs using microbubble-assisted ultrasound in digestive oncology: From preclinical to clinical studies Jean-Michel Escoffre,Najib Sekkat,Edward Oujagir,Sylvie Bodard,Coralie Moussetet al. Expert Opinion on Drug Delivery, 2022, Online ahead of print. ⟨10.1080/17425247.2022.2061459⟩ Article dans une revue inserm-03626073v1
Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS? Hugo Alarcan,Yara Al Ojaimi,Debora Lanznaster,Jean-Michel Escoffre,Philippe Corciaet al. Journal of Personalized Medicine, 2022, 12, pp.1071. ⟨10.3390/jpm12071071⟩ Article dans une revue inserm-03723283v1
Acoustic and Elastic Properties of a Blood Clot during Microbubble-Enhanced Sonothrombolysis: Hardening of the Clot with Inertial Cavitation Laurent Auboire,Damien Fouan,Jean-Marc Grégoire,Fréderic Ossant,Camille Plaget al. Pharmaceutics, 2021, 13, pp.1566. ⟨10.3390/pharmaceutics13101566⟩ Article dans une revue inserm-03354808v1
Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities? Suzanne Dufresne,Cindy Richard,Arthur Dieumegard,Luz Orfila,Gregory Delponet al. Cancers, 2021, 13 (21), pp.5402. ⟨10.3390/cancers13215402⟩ Article dans une revue inserm-03409985v1
Ultrasound-responsive cavitation nuclei for therapy and drug delivery Klazina Kooiman,Silke Roovers,Simone a G Langeveld,Robert T Kleven,Heleen Dewitteet al. Ultrasound in Medicine & Biology, In press Article dans une revue inserm-02437994v1
A systematic review of ultrasound imaging and therapy in mental disorders Marta Andrea Siragusa,Jean-Pierre Remenieras,Ayache Bouakaz,Jean-Michel Escoffre,Frédéric Patatet al. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 101, pp.109919. ⟨10.1016/j.pnpbp.2020.109919⟩ Article dans une revue inserm-02519433v1
Endothelial Cells, First Target of Drug Delivery Using Microbubble-Assisted Ultrasound Antoine Presset,Corentin Bonneau,Sasaoka Kazuyoshi,Lydie Nadal-Desbarats,Takigucho Mitsuyoshiet al. Ultrasound in Medicine & Biology, 2020, Online ahead of print. ⟨10.1016/j.ultrasmedbio.2020.03.013⟩ Article dans une revue inserm-02565367v1
New insights on the role of ROS in the mechanisms of sonoporation-mediated gene delivery Jean-Michel Escoffre,Pablo Campomanes,Mounir Tarek,Ayache Bouakaz Ultrasonics Sonochemistry, 2020, 64, pp.104998. ⟨10.1016/j.ultsonch.2020.104998⟩ Article dans une revue inserm-02488866v1
Editorial: Bubbles, Droplets and Micelles for Acoustically-Mediated Drug/Gene Delivery Jean-Michel Escoffre,Baudouin Denis de Senneville,Noboru Sasaki,Marc Derieppe Frontiers in Pharmacology, 2020, 11, pp.954. ⟨10.3389/fphar.2020.00954⟩ Article dans une revue inserm-02915877v1
Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model Fabien Espitalier,François Darrouzain,Jean-Michel Escoffre,David Ternant,Eric Piveret al. Frontiers in Pharmacology, 2020, 10, pp.1562. ⟨10.3389/fphar.2019.01562⟩ Article dans une revue inserm-02441635v1
Assessment of Intratumoral Doxorubicin Penetration after Mild Hyperthermia-mediated Release from Thermosensitive Liposomes Marc Derieppe,Jean-Michel Escoffre,Baudouin Denis de Senneville,Quincy van Houtum,Angelique Barten-van Rijbroeket al. Contrast Media and Molecular Imaging, 2019, ⟨10.1155/2019/2645928⟩ Article dans une revue hal-02377672v1
Minireview: Biophysical Mechanisms of Cell Membrane Sonopermeabilization. Knowns and Unknowns Jean-Michel Escoffre,Ayache Bouakaz Langmuir, 2019, 35 (31), pp.10151-10165. ⟨10.1021/acs.langmuir.8b03538⟩ Article dans une revue inserm-02438144v1
Quantitative Ultrasound in Ex Vivo Fibrotic Rabbit Livers Emilie Franceschini,Jean-Michel Escoffre,Anthony Novell,Laurent Auboire,Vanda Mendeset al. Ultrasound in Medicine & Biology, 2019, 45 (7), pp.1777-1786. ⟨10.1016/j.ultrasmedbio.2019.02.013⟩ Article dans une revue hal-02200101v1
Experience implication in subjective surgical ergonomics comparison between laparoscopic and robot-assisted surgeries V. Mendes,Franck Bruyère,Jean-Michel Escoffre,Aurélien Binet,Hubert Lardyet al. Journal of Robotic Surgery, 2019, ⟨10.1007/s11701-019-00933-2⟩ Article dans une revue inserm-02438134v1
Enhancing Nab-Paclitaxel Delivery Using Microbubble-Assisted Ultrasound in a Pancreatic Cancer Model Diane Bressand,Anthony Novell,Alban Girault,William Raoul,Gaëlle Fromont-Hankardet al. Molecular Pharmaceutics, 2019, 16 (9), pp.3814-3822. ⟨10.1021/acs.molpharmaceut.9b00416⟩ Article dans une revue hal-02301225v1
Comment on “The Enhancing Effect of Focused Ultrasound on TNK-Tissue Plasminogen Activator-Induced Thrombolysis using an In Vitro Circulating Flow Model” Laurent Auboire,Jean-Michel Escoffre Journal of Stroke and Cerebrovascular Diseases, 2019, 28 (7), pp.2052. ⟨10.1016/j.jstrokecerebrovasdis.2019.03.039⟩ Article dans une revue inserm-02438124v1
Experimental Implementation of a Pulse Compression Technique Using Coherent Plane-Wave Compounding Yanis Mehdi Benane,Denis Bujoreanu,Roberto J Lavarello,F. Varray,Jean-Michel Escoffreet al. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2018, 65 (6), pp.1025 - 1036. ⟨10.1109/TUFFC.2018.2820747⟩ Article dans une revue hal-01957676v1
Microbubbles combined with ultrasound therapy in ischemic stroke: A systematic review of in-vivo preclinical studies Laurent Auboire,Charles Sennoga,Jean-Marc Hyvelin,Frédéric Ossant,Jean-Michel Escoffreet al. PLoS ONE, 2018, 13 (2), pp.e0191788. ⟨10.1371/journal.pone.0191788⟩ Article dans une revue hal-01761337v1
Development of a Fluid Dynamic Model for Quantitative Contrast-Enhanced Ultrasound Imaging Baudouin Denis de Senneville,Anthony Novell,Chloé J. Arthuis,Vanda Mendes,Paul-Armand Dujardinet al. IEEE Transactions on Medical Imaging, 2018, 37 (2), pp.372-383 Article dans une revue hal-01962485v1
Real-Time Monitoring of Placental Oxygenation during Maternal Hypoxia and Hyperoxygenation Using Photoacoustic Imaging Chloé J. Arthuis,Anthony Novell,Florian Raes,Jean-Michel Escoffre,Stéphanie Lerondelet al. PLoS ONE, 2017, 12 (1), pp.e0169850. ⟨10.1371/journal.pone.0169850⟩ Article dans une revue inserm-02438173v1
Microbubble-Assisted Ultrasound-Induced Transient Phosphatidylserine Translocation Jean-Michel Escoffre,Marc Derieppe,Bart Lammertink,Clemens Bos,Chrit Moonen Ultrasound in Medicine & Biology, 2017, 43 (4), pp.838-851. ⟨10.1016/j.ultrasmedbio.2016.12.002⟩ Article dans une revue inserm-02438167v1
Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis Laurent Auboire,Jean-Michel Escoffre,Damien Fouan,Jean-René Jacquet,Frédéric Ossantet al. Scientific Reports, 2017, 7 (1), pp.6211. ⟨10.1038/s41598-017-06089-z⟩ Article dans une revue inserm-02438161v1
Microbubble-mediated ultrasound drug-delivery and therapeutic monitoring Charles Sennoga,Emma Kanbar,Laurent Auboire,Paul-Armand Dujardin,Damien Fouanet al. Expert Opinion on Drug Delivery, 2016, 14 (9), pp.1031-1043. ⟨10.1080/17425247.2017.1266328⟩ Article dans une revue inserm-02438187v1
Mild hyperthermia influence on Herceptin® properties Jean-Michel Escoffre,Roel Deckers,Noboru Sasaki,Clemens Bos,Chrit Moonen Radiology and Oncology, 2015, 49 (1), pp.41-49. ⟨10.2478/raon-2014-0045⟩ Article dans une revue inserm-02438251v1
Formulation and Pharmacokinetics of Thermosensitive Stealth® Liposomes Encapsulating 5-Fluorouracil Chantal Al Sabbagh,Nicolas Tsapis,Anthony Novell,Patricia Calleja-Gonzalez,Jean-Michel Escoffreet al. Pharmaceutical Research, 2015, 32 (5), pp.1585-1603. ⟨10.1007/s11095-014-1559-0⟩ Article dans une revue inserm-02438401v1
Recruitment of endocytosis in sonopermeabilization-mediated drug delivery: A real-time study Marc Derieppe,Katarzyna Rojek,Jean-Michel Escoffre,Baudouin Denis de Senneville,Chrit T. W. Moonenet al. Physical Biology, 2015 Article dans une revue hal-01159814v1
Focused ultrasound influence on calcein-loaded thermosensitive stealth liposomes Anthony Novell,Chantal Al Sabbagh,Jean-Michel Escoffre,Cedric Gaillard,Nicolas Tsapiset al. International Journal of Hyperthermia, 2015, 31 (4), pp.349-358. ⟨10.3109/02656736.2014.1000393⟩ Article dans une revue inserm-02438261v1
Recruitment of endocytosis in sonopermeabilization-mediated drug delivery: a real-time study Marc Derieppe,Katarzyna Rojek,Jean-Michel Escoffre,Baudouin Denis de Senneville,Chrit Moonenet al. Physical Biology, 2015, 12 (4), pp.046010. ⟨10.1088/1478-3975/12/4/046010⟩ Article dans une revue inserm-02438247v1
Development of a tumor tissue-mimicking model with endothelial cell layer and collagen gel for evaluating drug penetration Noboru Sasaki,Clemens Bos,Jean-Michel Escoffre,Gert Storm,Chrit Moonen International Journal of Pharmaceutics, 2015, 482 (1-2), pp.118-122. ⟨10.1016/j.ijpharm.2015.01.039⟩ Article dans une revue inserm-02438274v1
Sonochemotherapy: from bench to bedside Bart Lammertink,Clemens Bos,Roel Deckers,Gert Storm,Chrit Moonenet al. Frontiers in Pharmacology, 2015, 6, ⟨10.3389/fphar.2015.00138⟩ Article dans une revue inserm-02438239v1
Role of endocytosis in sonoporation-mediated membrane permeabilization and uptake of small molecules: a electron microscopy study A Zeghimi,Jean-Michel Escoffre,Ayache Bouakaz Physical Biology, 2015, 12 (6), pp.066007. ⟨10.1088/1478-3975/12/6/066007⟩ Article dans une revue inserm-02438214v1
Evaluation of chirp reversal power modulation sequence for contrast agent imaging Novell Anthony,Charles Sennoga,Jean-Michel Escoffre,Jennifer Chaline,Ayache Bouakaz Physics in Medicine and Biology, 2014, 59 (17), pp.5101-5117. ⟨10.1088/0031-9155/59/17/5101⟩ Article dans une revue inserm-02438448v1
Membrane disorder and phospholipid scrambling in electropermeabilized and viable cells Jean-Michel Escoffre,Elisabeth Bellard,Cécile Faurie,Sarah C. Sébaï,Muriel Golzioet al. Biochimica et Biophysica Acta:Biomembranes, 2014, 1838 (7), pp.1701-1709. ⟨10.1016/j.bbamem.2014.02.013⟩ Article dans une revue inserm-02438553v1
Serum influence on in-vitro gene delivery using microbubble-assisted ultrasound Aya Zeghimi,Novell Anthony,Rose-Anne Thepault,Patrick Vourc'H,Ayache Bouakazet al. Journal of Drug Targeting, 2014, 22 (8), pp.748-760. ⟨10.3109/1061186X.2014.921922⟩ Article dans une revue inserm-02438479v1
Evidence for electro-induced membrane defects assessed by lateral mobility measurement of a GPi anchored protein Jean-Michel Escoffre,Marie Hubert,Justin Teissié,Marie-Pierre Rols,Cyril Favard European Biophysics Journal, 2014, 43 (6-7), pp.277-286. ⟨10.1007/s00249-014-0961-1⟩ Article dans une revue inserm-02438517v1
Bleomycin delivery into cancer cells in vitro with ultrasound and SonoVue® or BR14® microbubbles Nerijus Lamanauskas,Novell Anthony,Jean-Michel Escoffre,Mindaugas Venslauskas,Saulius Satkauskaset al. Journal of Drug Targeting, 2013, 21 (4), pp.407-414. ⟨10.3109/1061186X.2012.761223⟩ Article dans une revue inserm-02438654v1
Irinotecan Delivery by Microbubble-Assisted Ultrasound: In Vitro Validation and a Pilot Preclinical Study Jean-Michel Escoffre,Novell Anthony,Sophie Serriere,Thierry Lecomte,Ayache Bouakaz Molecular Pharmaceutics, 2013, 10 (7), pp.2667-2675. ⟨10.1021/mp400081b⟩ Article dans une revue inserm-02438593v1
Second Harmonic and Subharmonic for Non-Linear Wideband Contrast Imaging Using a Capacitive Micromachined Ultrasonic Transducer Array Novell Anthony,Jean-Michel Escoffre,Ayache Bouakaz Ultrasound in Medicine & Biology, 2013, 39 (8), pp.1500-1512. ⟨10.1016/j.ultrasmedbio.2013.03.002⟩ Article dans une revue inserm-02438581v1
Microbubble attenuation and destruction: are they involved in sonoporation efficiency? Jean-Michel Escoffre,Novell Anthony,Julien Piron,Aya Zeghimi,Alexander A Doinikov IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2013, 60 (1), ⟨10.1109/TUFFC.2013.2536⟩ Article dans une revue inserm-02438857v1
Effect of different parameters used for in vitro gene electrotransfer on gene expression efficiency, cell viability and visualization of plasmid DNA at the membrane level Sasa Haberl,Masa Kanduser,Karel Flisar,Dusa Hodzic,Vladimir Bostjan Bregaret al. The Journal of Gene Medicine, 2013, 15 (5), pp.169-181. ⟨10.1002/jgm.2706⟩ Article dans une revue istex inserm-02438609v1
In-Vivo Gene Delivery by Sonoporation: Recent Progress and Prospects Jean-Michel Escoffre,Aya Zeghimi,Novell Anthony,Ayache Bouakaz Current Gene Therapy, 2013, 13 (1), pp.2-14. ⟨10.2174/156652313804806606⟩ Article dans une revue inserm-02438876v1
Focused ultrasound mediated drug delivery from temperature-sensitive liposomes: in-vitro characterization and validation Jean-Michel Escoffre,Novell Anthony,Mariska de Smet,Ayache Bouakaz Physics in Medicine and Biology, 2013, 58 (22), pp.8135-8151. ⟨10.1088/0031-9155/58/22/8135⟩ Article dans une revue inserm-02438570v1
Doxorubicin liposome-loaded microbubbles for contrast imaging and ultrasound-triggered drug delivery Jean-Michel Escoffre,Christophoros Mannaris,Bart Geers,Anthony Novell,Ine Lentackeret al. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2013, 60 (1), pp.78-87. ⟨10.1109/TUFFC.2013.2539⟩ Article dans une revue inserm-02438665v1
New insights into uteroplacental perfusion: Quantitative analysis using Doppler and contrast-enhanced ultrasound imaging Chloé Julie Arthuis,Novell Anthony,Jean-Michel Escoffre,Frédéric Patat,Ayache Bouakazet al. Placenta, 2013, 34 (5), pp.424-431. ⟨10.1016/j.placenta.2013.01.019⟩ Article dans une revue istex inserm-02438627v1
Electrochemotherapy: Progress and Prospects. Jean-Michel Escoffre,Marie-Pierre Rols Current Pharmaceutical Design, 2012, epub ahead of print Article dans une revue inserm-00680356v1
Electrochemotherapy: Progress and Prospects Jean-Michel Escoffre,Marie-Pierre Rols Current Pharmaceutical Design, 2012, 18 (23), pp.3406-3415. ⟨10.2174/138161212801227087⟩ Article dans une revue inserm-02438896v1
Drug delivery by electropulsation: Recent developments in oncology Teissié Justin,Jean-Michel Escoffre,Aurélie Paganin-Gioanni,Sophie Chabot,Elisabeth Bellardet al. International Journal of Pharmaceutics, 2012, 423 (1), pp.3-6. ⟨10.1016/j.ijpharm.2011.09.038⟩ Article dans une revue inserm-02438916v1
Destabilizing Giant Vesicles with Electric Fields: An Overview of Current Applications Thomas Portet,Chloé Mauroy,Vincent Démery,Thibault Houles,Jean-Michel Escoffreet al. Journal of Membrane Biology, 2012, 245 (9), pp.555-564. ⟨10.1007/s00232-012-9467-x⟩ Article dans une revue istex hal-00998473v1
New Insights in the Gene Electrotransfer Process: Evidence for the Involvement of the Plasmid DNA Topology Jean-Michel Escoffre,Biliana Nikolova,Laetitia Mallet,Julien Henri,Cyril Favardet al. Current Gene Therapy, 2012, 12 (5), pp.417-422. ⟨10.2174/156652312802762554⟩ Article dans une revue inserm-02438890v1
Hyaluronidase and Collagenase Increase the Transfection Efficiency of Gene Electrotransfer in Various Murine Tumors Maja Cemazar,Muriel Golzio,Gregor Sersa,Jean-Michel Escoffre,Andrej Coeret al. Human Gene Therapy, 2012, 23 (1), pp.128-137. ⟨10.1089/hum.2011.073⟩ Article dans une revue inserm-02438934v1
Cholesterol implications in plasmid DNA electrotransfer: Evidence for the involvement of endocytotic pathways Christelle Rosazza,Émilie Phez,Jean-Michel Escoffre,Laurence Cézanne,Andreas Zumbuschet al. International Journal of Pharmaceutics, 2012, 423 (1), pp.134-143. ⟨10.1016/j.ijpharm.2011.05.024⟩ Article dans une revue inserm-02438956v1
Doxorubicin Delivery into Tumor Cells with Ultrasound and Microbubbles Jean-Michel Escoffre,Julien Piron,Novell Anthony,Ayache Bouakaz Molecular Pharmaceutics, 2011, 8 (3), pp.799-806. ⟨10.1021/mp100397p⟩ Article dans une revue inserm-02438975v1
The Actin Cytoskeleton Has an Active Role in the Electrotransfer of Plasmid DNA in Mammalian Cells Christelle Rosazza,Jean-Michel Escoffre,Andreas Zumbusch,Marie-Pierre Rols Molecular Therapy, 2011, 19 (5), pp.913-921. ⟨10.1038/mt.2010.303⟩ Article dans une revue inserm-02438983v1
Electromediated formation of DNA complexes with cell membranes and its consequences for gene delivery Jean-Michel Escoffre,Thomas Portet,Cyril Favard,Justin Teissié,David S. Deanet al. Biochimica et Biophysica Acta:Biomembranes, 2011, 1808 (6), pp.1538-1543. ⟨10.1016/j.bbamem.2010.10.009⟩ Article dans une revue hal-00998724v1
Direct visualization at the single-cell level of siRNA electrotransfer into cancer cells Aurélie Paganin-Gioanni,Elisabeth Bellard,Jean-Michel Escoffre,Marie-Pierre Rols,Teissié Justinet al. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (26), pp.10443-10447. ⟨10.1073/pnas.1103519108⟩ Article dans une revue inserm-02438940v1
Gene Transfer: How Can the Biological Barriers Be Overcome? Jean-Michel Escoffre,Justin Teissié,Marie-Pierre Rols Journal of Membrane Biology, 2010, 236 (1), pp.61-74. ⟨10.1007/s00232-010-9275-0⟩ Article dans une revue istex inserm-02439003v1
In Vitro Gene Transfer by Electrosonoporation Jean-Michel Escoffre,Kadija Kaddur,Marie-Pierre Rols,Ayache Bouakaz Ultrasound in Medicine & Biology, 2010, 36 (10), pp.1746-1755. ⟨10.1016/j.ultrasmedbio.2010.06.019⟩ Article dans une revue inserm-02438997v1
Observations of the Mechanisms of Electromediated DNA Uptake - From Vesicles to Tissues Muriel Golzio,Jean-Michel Escoffre,Thomas Portet,Chloé Mauroy,Justin Teissiéet al. Current Gene Therapy, 2010, 10 (4), pp.256-266. ⟨10.2174/156652310791823461⟩ Article dans une revue hal-00999322v1
Electro-mediated gene transfer and expression are controlled by the life-time of DNA/membrane complex formation Cécile Faurie,Matej Reberšek,Muriel Golzio,Masa Kanduser,Jean-Michel Escoffreet al. The Journal of Gene Medicine, 2010, 12 (1), pp.117-125. ⟨10.1002/jgm.1414⟩ Article dans une revue inserm-02439034v1
Gene electrotransfer: from biophysical mechanisms to in vivo applications. Part 2 - In vivo developments and present clinical applications Jean-Michel Escoffre,Chloé Mauroy,Thomas Portet,Luc Wasungu,Aurélie Paganin-Gioanniet al. Biophysical Reviews and Letters, 2009, 1 (4), pp.185-191. ⟨10.1007/s12551-009-0019-2⟩ Article dans une revue inserm-02439026v1
What is (Still not) Known of the Mechanism by Which Electroporation Mediates Gene Transfer and Expression in Cells and Tissues Jean-Michel Escoffre,Thomas Portet,Luc Wasungu,Teissié Justin,David S. Deanet al. Molecular Biotechnology, 2009, 41 (3), pp.286-295. ⟨10.1007/s12033-008-9121-0⟩ Article dans une revue istex inserm-02439136v1
Transgene expression of transfected supercoiled plasmid DNA concatemers in mammalian cells Jean-Michel Escoffre,Elisabeth Bellard,Muriel Golzio,Justin Teissié,Marie-Pierre Rols The Journal of Gene Medicine, 2009, 11 (11), pp.1071-1073. ⟨10.1002/jgm.1384⟩ Article dans une revue istex inserm-02439039v1
A 3D in vitro spheroid model as a way to study the mechanisms of electroporation Luc Wasungu,Jean-Michel Escoffre,Annie Valette,Justin Teissié,Marie-Pierre Rols International Journal of Pharmaceutics, 2009, 379 (2), pp.278-284. ⟨10.1016/j.ijpharm.2009.03.035⟩ Article dans une revue istex inserm-02439046v1
Visualization of Membrane Loss during the Shrinkage of Giant Vesicles under Electropulsation Thomas Portet,Franc Camps I Febrer,Jean-Michel Escoffre,Cyril Favard,Marie-Pierre Rolset al. Biophysical Journal, 2009, 96 (10), pp.4109-4121. ⟨10.1016/j.bpj.2009.02.063⟩ Article dans une revue inserm-02439154v1
Long-lasting In vivo Gene Silencing by Electrotransfer of shRNA Expressing Plasmid Jean-Michel Escoffre,Arnaud Debin,Jean-Paul Reynes,Daniel Drocourt,Gérard Tirabyet al. Technology in Cancer Research and Treatment, 2008, 7 (2), pp.109-116. ⟨10.1177/153303460800700203⟩ Article dans une revue inserm-02439064v1
Membrane perturbation by an external electric field: a mechanism to permit molecular uptake Jean-Michel Escoffre,David S. Dean,Marie Hubert,Marie-Pierre Rols,Cyril Favard European Biophysics Journal, 2007, 36 (8), pp.973-983. ⟨10.1007/s00249-007-0194-7⟩ Article dans une revue istex inserm-02439124v1
In vivo imaging of tumor growth after electrochemotherapy with cisplatin Maja Cemazar,Muriel Golzio,Jean-Michel Escoffre,Bettina Couderc,Gregor Sersaet al. Biochemical and Biophysical Research Communications, 2006, 348 (3), pp.997-1002. ⟨10.1016/j.bbrc.2006.07.132⟩ Article dans une revue istex inserm-02439075v1

Communication dans un congrès (21)

Formation de Faisceaux Adaptée à une Sonde Bimodale pour la Sonoporation Guidée par Ultrasons Juline Cloet,Rémi Rouffaud,Mathieu Legros,Jean-Michel Escoffre,Damien Fouanet al. CFA 2025 - 17e Congrès Français d'Acoustique, Société Française d'Acoustique (SFA), Apr 2025, Paris, France Communication dans un congrès hal-05365910v1
A Dual-Core Ultrasound Probe For Image-Guided Sonoporation: Application to Anti-Cancer Immunotherapy Mathieu Legros,Remi Rouffaud,Laurent Colin,Dominique Gross,Dominique Certonet al. 2022 IEEE International Ultrasonics Symposium (IUS), Oct 2022, Venice, Italy. pp.1-4, ⟨10.1109/IUS54386.2022.9958841⟩ Communication dans un congrès hal-04164933v1
Irinotecan delivery by microbubble-assisted ultrasound - A pilot preclinical study Jean-Michel Escoffre,Anthony Novell,Sophie Serrière,Ayache Bouakaz 12th International Symposium on Therapeutic Ultrasound, Jun 2012, Heidelberg (Germany), Germany. pp.40-45, ⟨10.1063/1.4769914⟩ Communication dans un congrès hal-04280331v1
Analysis of Contrast-Enhanced Ultrasound using fluid dynamic Baudouin Denis de Senneville,Anthony Novell,Chloé J. Arthuis,Vanda Mendes,Paul-Armand Dujardinet al. IEEE International Symposium on Biomedical Imaging (ISBI), Apr 2018, Washington, United States Communication dans un congrès hal-01963092v1
A fluid dynamic model for quantitative contrast-enhanced ultrasound imaging: validation for the assessment of uteroplacental perfusion Baudouin Denis de Senneville,Anthony Novell,Chloé J. Arthuis,Vanda Mendes,Paul-Armand Dujardinet al. IEEE International Ultrasonics Symposium, Oct 2018, Kobe, Japan Communication dans un congrès hal-01963238v1
Lattice of nonlinear coupled oscillators: An acousto-mechanical analogy of gas microbubble Jennifer Chaline,Ayache Bouakaz,Jean-Michel Escoffre,Victor Sanchez-Morcillo,Noe Jimenezet al. 2014 IEEE International Ultrasonics Symposium, Sep 2014, Chicago (IL), United States. pp.2277-2279, ⟨10.1109/ultsym.2014.0567⟩ Communication dans un congrès hal-04280323v1
Involvement of cytoskeleton in sonoporation and drug delivery Aya Zeghimi,Jean-Michel Escoffre,Ayache Bouakaz 2014 IEEE International Ultrasonics Symposium, Sep 2014, Chicago (IL), United States. pp.850-853, ⟨10.1109/ultsym.2014.0209⟩ Communication dans un congrès hal-04280322v1
Ultrastructural sonoporation bio-effects: Comparative study on two human cancer cell lines Aya Zeghimi,Jean-Michel Escoffre,Ayache Bouakaz 2013 IEEE International Ultrasonics Symposium (IUS), Jul 2013, Prague, Czech Republic. pp.61-64, ⟨10.1109/ultsym.2013.0016⟩ Communication dans un congrès hal-04280326v1
Ultrastructural modifications of cell membranes and organelles induced by sonoporation Aya Zeghimi,Rustem Uzbekov,Brigite Arbeille,Jean-Michel Escoffre,Ayache Bouakaz 2012 IEEE International Ultrasonics Symposium (IUS), Oct 2012, Dresden (Germany), Germany. pp.2045-2048, ⟨10.1109/ultsym.2012.0511⟩ Communication dans un congrès hal-04280327v1
High-intensity focused ultrasound-mediated doxorubicin delivery with thermosensitive liposomes Jean-Michel Escoffre,Christophoros Mannaris,Anthony Novell,Laëtitia Rioc,Marie-Edith Meyreet al. 11TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND, Apr 2011, New York, NY, United States. pp.81-87, ⟨10.1063/1.4757315⟩ Communication dans un congrès hal-04280336v1
Role of thermal and mechanical effects on drug release from thermosensitive nanocarriers Anthony Novell,Jean-Michel Escoffre,Chantal Al-Sabbagh,Christophoros Mannaris,Elias Fattalet al. 2012 IEEE International Ultrasonics Symposium, Oct 2012, Dresden (GERMANY), Germany. pp.1873-1876, ⟨10.1109/ultsym.2012.0470⟩ Communication dans un congrès hal-04280329v1
Doxorubicin-liposomes loaded microbubbles for ultrasound-triggered doxorubicin delivery Jean-Michel Escoffre,Anthony Novell,Bart Geers,Ine Lentacker,Ayache Bouakaz Acoustics 2012, Apr 2012, Nantes, France Communication dans un congrès hal-00810695v1
Blood-brain barrier disruption with focused ultrasound enhances delivery of dopamine transporter tracer (PE2I) into the brain Jean-Michel Escoffre,Sophie Serrière,Sylvie Bodard,Anthony Novell,Sylvie Chalonet al. Acoustics 2012, Apr 2012, Nantes, France Communication dans un congrès hal-00810925v1
Delivery of dopamine transporter tracer (PE2I) through blood brain barrier with ultrasound and microbubbles Sophie Serriere,Jean-Michel Escoffre,Sylvie Bodard,Anthony Novel,Anthony Novellet al. 11. International Symposium on Therapeutic Ultrasound, American Institute of Physics. Melville, USA., Apr 2011, New York, United States. ⟨10.1063/1.4757355⟩ Communication dans un congrès hal-02746677v1
Enhanced gene transfection using ultrasound and Vevo Micromarker ® microbubbles Julien Piron,Jean-Michel Escoffre,Kadija Kaddur,Anthony Novell,Ayache Bouakaz 2010 IEEE International Ultrasonics Symposium, Oct 2010, San Diego, United States. ⟨10.1109/ULTSYM.2010.5935896⟩ Communication dans un congrès hal-04280337v1
Dynamic of DNA/membrane interaction after electrotransfection process. J.M. Escoffre,E. Phez,C. Favard,J. Teissié,M.P. Rols XIIIth Meeting of Study Group of Molecules – Membranes Interactions, 2008, Strasbourg, France Communication dans un congrès hal-00455675v1
DNA electrotransfection: effects of electric fields on cell membrane J.M. Escoffre,E. Phez,L. Cézanne,F. Camps,David S. Deanet al. XIXth International Symposium of BioElectrochemistry Society, 2007, Toulouse, France Communication dans un congrès hal-00455681v1
In vivo imaging of siRNA electrotransfer and silencing in different organs Aurélie Paganin-Gioanni,Jean-Michel Escoffre,Laurent Mazzolini,Marie-Pierre Rols,Justin Teissieet al. 11th Mediterranean Conference on Medical and Biological Engineering and Computing 2007, Jun 2007, Ljubljana, Slovenia Communication dans un congrès hal-04280340v1
New insights on mechanisms of electrogenetransfer J.M. Escoffre,E. Phez,F. Camps,Thomas Portet,David S. Deanet al. XXIIth Scientific days of Thematic Group of Research on Vectorisation., 2007, Strasbourg, France Communication dans un congrès hal-00455678v1
DNA electrotransfection: Electric field effects on cell membrane J.M. Escoffre,E. Phez,L. Cézanne,F. Camps,David S. Deanet al. VIth National Congress of Francophone Society of Cell and Gene Therapy, 2007, Giens, France Communication dans un congrès hal-00455679v1
DNA/membrane interaction: a key step of electrotransfection J.M. Escoffre,E. Phez,F. Camps,C. Favard,J. Teissiéet al. VIth European Biophysics Congress, 2006, London, United Kingdom Communication dans un congrès hal-00455676v1

Ouvrages (1)

Therapeutic Ultrasound Jean-Michel Escoffre,Ayache Bouakaz , 2016, ⟨10.1007/978-3-319-22536-4⟩ Ouvrages inserm-02439296v1

Chapitre d'ouvrage (5)

Bubble-Assisted Ultrasound: Application in Immunotherapy and Vaccination Jean-Michel Escoffre,Roel Deckers,Clemens Bos,Chrit Moonen Therapeutic Ultrasound, In press, ⟨10.1007/978-3-319-22536-4_14⟩ Chapitre d'ouvrage inserm-02438234v1
Encapsulated Bubble Dynamics in Imaging and Therapy Alexander Doinikov,Anthony Novell,Jean-Michel Escoffre,Ayache Bouakaz Bubble Dynamics and Shock Waves, Springer Berlin Heidelberg, pp.259-289, 2013, 978-3-642-34296-7. ⟨10.1007/978-3-642-34297-4_9⟩ Chapitre d'ouvrage istex hal-04281268v1
shRNA-Mediated Gene Knockdown in Skeletal Muscle Muriel Golzio,Jean-Michel Escoffre,Teissié Justin Myogenesis, pp.491-501, 2012, ⟨10.1007/978-1-61779-343-1_29⟩ Chapitre d'ouvrage inserm-02438906v1
Electrotransfer of Plasmid DNA Jean-Michel Escoffre,Marie-Pierre Rols,David Dean Clinical Aspects of Electroporation, Springer New York, pp.145-157, 2011, ⟨10.1007/978-1-4419-8363-3_13⟩ Chapitre d'ouvrage hal-04281264v1
Gene electrotransfer: from biophysical mechanisms to in vivo applications. Part 1 . Biophysical mechanisms Jean-Michel Escoffre,Chloé Mauroy,Thomas Portet,Luc Wasungu,Christelle Rosazzaet al. Advanced Electroporation Techniques in Biology and Medicine, 1 (4), pp.177-184, 2009, ⟨10.1007/s12551-009-0022-7⟩ Chapitre d'ouvrage inserm-02439017v1

Thèse (4)

Délivrance de molécules thérapeutiques par sonoporation dans un modèle murin de métastases hépatiques de cancer colorectal Marie Roy,Sophie Serrière,Jean-Michel Escoffre Sciences du Vivant [q-bio]. Université de Tours (UT), Tours, FRA, 2024. Français. ⟨NNT : ⟩ Thèse tel-04852326v1
Influence de paramètres acoustiques sur l’efficacité de la neurostimulation ultrasonore : dispositif expérimental et étude préclinique Tarik Iazourene,Jean-Michel Escoffre,Ayache Bouakaz Sciences du Vivant [q-bio]. Université de Tours (UT), Tours, FRA, 2022. Français. ⟨NNT : ⟩ Thèse tel-04852769v1
Etude des conséquences neurophysiologiques de l’ouverture de la barrière hémato-encéphalique par sonoporation Antoine Presset,Lydie Nadal-Desbarats,Jean-Michel Escoffre Sciences du Vivant [q-bio]. Université de Tours (UT), Tours, FRA, 2022. Français. ⟨NNT : ⟩ Thèse tel-04852347v1
Mécanismes moléculaires et cellulaire de l'électrotransfert de plasmides in vitro Jean-Michel Escoffre Sciences du Vivant [q-bio]. Université Paul Sabatier (Toulouse 3), 2010. Français. ⟨NNT : ⟩ Thèse tel-04280318v1