jean-philippe herbeuval

Identifiants chercheurs

IdHAL :

jean-philippe-herbeuval

ORCID :

0000-0001-8114-8012

IdRef :

070408793

Présentation

Publications

Article dans une revue (51)

Investigation of the binding mode of clobenprobit at CXCR4 and development of novel anti-inflammatory compounds with enhanced activity and minimal antagonist effects Birgit Caspar,Nassima Bekaddour,Séverine Grinberg,Dominique Cathelin,Ivana Stoilovaet al. Molecular Pharmacology, 2025, 107 (8), pp.100055. ⟨10.1016/j.molpha.2025.100055⟩ Article dans une revue hal-05379090v1
Multivariate Screening and Automated Clustering of Macrophage Immunoreactome to Nanoparticles and Photothermal Therapy Sonia Becharef,Léa Jabbour,Nassima Bekaddour,Giulio Avveduto,Nathalie Lucianiet al. Advanced Science, 2025, 12 (31), pp.2405860. ⟨10.1002/advs.202405860⟩ Article dans une revue hal-05407954v1
Size-dependent immunomodulation by MSC secretome: soluble factors target innate pathways, components larger than 100 kDa regulate T cell proliferation Christophe Wong,Isaure Rous,Shony Lemieux,Jeanne Volatron,Nassima Bekaddouret al. Current Stem Cell Research & Therapy, 2025, 16 (1), pp.556. ⟨10.1186/s13287-025-04670-2⟩ Article dans une revue hal-05379096v1
Macrophages: Key Cellular Players in HIV Infection and Pathogenesis Marie Woottum,Sen Yan,Sophie Sayettat,Séverine Grinberg,Dominique Cathelinet al. Viruses, 2024, 16, ⟨10.3390/v16020288⟩ Article dans une revue hal-04727692v1
The histamine analogue clobenpropit modulates IRF7 phosphorylation and interferon production by targeting CXCR4 in systemic lupus erythematosus models Nassima Bekaddour,Nikaïa Smith,Birgit Caspar,Séverine Grinberg,Stéphane Giorgiuttiet al. Frontiers in Immunology, 2024, 15, pp.1490593. ⟨10.3389/fimmu.2024.1490593⟩ Article dans une revue hal-04955133v1
Macrophages: Key Cellular Players in HIV Infection and Pathogenesis Marie Woottum,Sen Yan,Sophie Sayettat,Séverine Grinberg,Dominique Cathelinet al. Viruses, 2024, 16 (2), pp.288. ⟨10.3390/v16020288⟩ Article dans une revue hal-05038279v1
Pathogenic variants in the NLRP3 LRR domain at position 861 are responsible for a boost-dependent atypical CAPS phenotype. Antoine Fayand,Margaux Cescato,Laurent Le Corre,Alexandre Terré,Margaux Wacheuxet al. Journal of Allergy and Clinical Immunology, 2023, 152 (5), pp.1303-1311.e1. ⟨10.1016/j.jaci.2023.07.006⟩ Article dans une revue hal-04182567v1
Editorial: Type 1 interferon in pathologies, autoimmune diseases, and chronic viral infections: understanding the fascinating biologic role of type 1 interferons Jean-Philippe Herbeuval Frontiers in Immunology, 2023, 14, pp.1239086. ⟨10.3389/fimmu.2023.1239086⟩ Article dans une revue hal-04198755v1
Successful treatment of JAK1 associated inflammatory disease Antoine Fayand,Véronique Hentgen,Céline Posseme,Carole Lacout,Capucine Picardet al. Journal of Allergy and Clinical Immunology, 2023, 152 (4), pp.972-983. ⟨10.1016/j.jaci.2023.06.004⟩ Article dans une revue hal-04137977v1
Targeting the chemokine receptor CXCR4 with histamine analog to reduce inflammation in juvenile arthritis Nassima Bekaddour,Nikaïa Smith,Benoit Beitz,Alba Llibre,Tom Dottet al. Frontiers in Immunology, 2023, 14, pp.1178172. ⟨10.3389/fimmu.2023.1178172⟩ Article dans une revue (article de synthèse) pasteur-04245544v2
Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection Mirja Harms,Nikaïa Smith,Mingyu Han,Rüdiger Groß,Pascal von Maltitzet al. Science Advances , 2023, 9 (27), pp.eadf8251. ⟨10.1126/sciadv.adf8251⟩ Article dans une revue hal-04198762v1
Are blockers of gp120/CD4 interaction effective inhibitors of HIV-1 immunopathogenesis? Jean-Philippe Herbeuval,Gene Shearer Aids Reviews, 2023, 8 (1), pp.3-8 Article dans une revue hal-04198886v1
Correction to: Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection Mathieu Paul Rodero,Stéphane Pelleau,Anne Welfringer-Morin,Darragh Duffy,Isabelle Melkiet al. Journal of Clinical Immunology, 2022, 42 (1), pp.28-28. ⟨10.1007/s10875-021-01135-y⟩ Article dans une revue hal-04198795v1
CXCR4 as a novel target in immunology: moving away from typical antagonists Birgit Caspar,Pietro Cocchiara,Armelle Melet,Kristof van Emelen,Annegret van der Aaet al. Future Drug Discovery, 2022, 4 (2), pp.FDD77. ⟨10.4155/fdd-2022-0007⟩ Article dans une revue (article de synthèse) hal-04198790v1
JAK inhibitors are effective in a subset of patients with juvenile dermatomyositis: a monocentric retrospective study Tom Le Voyer,Cyril Gitiaux,François-Jérôme Authier,Christine Bodemer,Isabelle Melkiet al. Rheumatology, 2021, pp.keab116. ⟨10.1093/rheumatology/keab116⟩ Article dans une revue pasteur-03236464v1
Differential levels of IFNα subtypes in autoimmunity and viral infection Vincent Bondet,Mathieu P. Rodero,Céline Posseme,Pierre Bost,Jérémie Decalfet al. Cytokine, 2021, 144 (8), pp.155533. ⟨10.1016/j.cyto.2021.155533⟩ Article dans une revue pasteur-03236276v2
Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition Simon Hayek,Nicolas Pietrancosta,Anna Hovhannisyan,Rodolphe Alves de Sousa,Nassima Bekaddouret al. European Journal of Medicinal Chemistry, 2020, 186, pp.111855. ⟨10.1016/j.ejmech.2019.111855⟩ Article dans une revue hal-02372490v1
Inhibition of IFNα secretion in cells from patients with juvenile dermatomyositis under TBK1 inhibitor treatment revealed by single-molecular assay technology Cyril Gitiaux,Vincent Bondet,Nassima Bekaddour,Patrick Nusbaum,Arnaud Hubaset al. Rheumatology, 2020, pp.kez508. ⟨10.1093/rheumatology/kez508⟩ Article dans une revue pasteur-02376263v1
Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue Nikaïa Smith,Nassima Bekaddour,Nicolas Leboulanger,Yolande Richard,Jean-Philippe Herbeuval Journal of visualized experiments : JoVE, 2020, 160, ⟨10.3791/60914⟩ Article dans une revue hal-03051482v1
Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine Vincent Gies,Nassima Bekaddour,Yannick Dieudonné,Aurélien Guffroy,Quentin Frengeret al. Frontiers in Immunology, 2020, 11, ⟨10.3389/FIMMU.2020.01409⟩ Article dans une revue hal-02996379v1
Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement—A new target for lupus treatment Nikaïa Smith,Mathieu Rodéro,Nassima Bekaddour,Vincent Bondet,Yasser Ruiz-Blancoet al. Science Advances , 2019, 5 (7), pp.eaav9019. ⟨10.1126/sciadv.aav9019⟩ Article dans une revue pasteur-02282952v1
Hitting the right spot on CXCR4 Jessica Mchugh,Jean-Philippe Herbeuval,Nikaia Smith Nature Reviews Rheumatology, 2019, 15 (9), pp.514-514. ⟨10.1038/s41584-019-0287-6⟩ Article dans une revue hal-02372533v1
TRIM8 is required for virus-induced IFN response in human plasmacytoid dendritic cells Ghizlane Maarifi,Nikaïa Smith,Sarah Maillet,Olivier Moncorgé,Célia Chamontinet al. Science Advances , 2019, 5 (11), pp.eaax3511. ⟨10.1126/sciadv.aax3511⟩ Article dans une revue hal-02404478v1
Immature particles and capsid-free viral RNA produced by Yellow fever virus-infected cells stimulate plasmacytoid dendritic cells to secrete interferons Laura Sinigaglia,Ségolène Gracias,Elodie Décembre,Matthieu Fritz,Daniela Bruniet al. Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-29235-7⟩ Article dans une revue hal-02327450v1
Identification of Primary Natural Killer Cell Modulators by Chemical Library Screening with a Luciferase-Based Functional Assay Simon Hayek,Nassima Bekaddour,Laurie Besson,Rodolphe Alves de Sousa,Nicolas Pietrancostaet al. Slas Discovery, 2018, 24 (1), pp.25-37. ⟨10.1177/2472555218797078⟩ Article dans une revue hal-02324386v1
Chemical pollution and innate antiviral immunity: Dangerous Liaisons ? Simon Hayek,Nicolas Pietrancosta,Rodolphe Alves De Sousa,Robert Barouki,Jean-Philippe Herbeuvalet al. Virologie, 2018, 22 (1), pp.1-13. ⟨10.1684/vir.2018.0717⟩ Article dans une revue hal-02351261v1
Pollution chimique et immunité innée antivirale : des liaisons dangereuses ? Simon Hayek,Nicolas Pietrancosta,Rodolphe Alves De Sousa,Robert Barouki,Jean-Philippe Herbeuvalet al. Virologie, 2018, 22 (1), pp.27-40. ⟨10.1684/vir.2018.0718⟩ Article dans une revue hal-03652525v1
Semen inhibits Zika virus infection of cells and tissues from the anogenital region Janis Müller,Mirja Harms,Franziska Krüger,Rüdiger Groß,Simone Joaset al. Nature Communications, 2018, 9 (1), pp.2207. ⟨10.1038/s41467-018-04442-y⟩ Article dans une revue hal-04249967v1
Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria Anas Allam,Laure Maigre,Julia Vergalli,Estelle Dumont,Bertrand Cinquinet al. Scientific Reports, 2017, 7 (1), pp.986. ⟨10.1038/s41598-017-00945-8⟩ Article dans une revue hal-03652530v1
Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement Nikaïa Smith,Nicolas Pietrancosta,Sophia Davidson,Jacques Dutrieux,Lise Chauveauet al. Nature Communications, 2017, 8, pp.14253. ⟨10.1038/ncomms14253⟩ Article dans une revue hal-02075366v1
CXCR4, le nouveau régulateur de l’immunité innée ? Nikaïa Smith,Nicolas Pietrancosta,Jean-Philippe Herbeuval Médecine/Sciences, 2017, 33 (8-9), pp.711-713. ⟨10.1051/medsci/20173308008⟩ Article dans une revue hal-02351272v1
Identification of a small molecule that primes the type I interferon response to cytosolic DNA Samira Khiar,Marianne Lucas-Hourani,Sebastien Nisole,Nikaia Smith,Olivier Helyncket al. Scientific Reports, 2017, 7 (1), pp.2561. ⟨10.1038/s41598-017-02776-z⟩ Article dans une revue pasteur-01570224v1
Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria Anas Allam,Laure Maigre,Julia Vergalli,Estelle Dumont,Bertrand Cinquinet al. Scientific Reports, 2017, 7 (1), pp.986. ⟨10.1038/s41598-017-00945-8⟩ Article dans une revue hal-01831783v1
An efficient method for gene silencing in human primary plasmacytoid dendritic cells: silencing of the TLR7/IRF-7 pathway as a proof of concept Nikaïa Smith,Pierre-Olivier Vidalain,Sébastien Nisole,Jean-Philippe Herbeuval Scientific Reports, 2016, 6 (1), ⟨10.1038/srep29891⟩ Article dans une revue hal-02438269v1
Plasmacytoid dendritic cells and myeloid cells differently contribute to BAFF over-expression during primary HIV infection Gwenoline Borhis,Chantal Burelout,Nada Chaoul,Nikaïa Smith,Cecile Goujardet al. AIDS. Official journal of the international AIDS Society, 2016, pp.1. ⟨10.1097/QAD.0000000000000965⟩ Article dans une revue hal-02346130v1
Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women. Morgane Griesbeck,Susanne Ziegler,Sophie Laffont,Nikaïa Smith,Lise Chauveauet al. Journal of Immunology, 2015, 195 (11), pp.5327-36. ⟨10.4049/jimmunol.1501684⟩ Article dans une revue pasteur-01372393v1
Reduction of death receptor 5 expression and apoptosis of CD4+ T cells from HIV controllers Lucie Barblu,Nikaïa Smith,Stéphanie Durand,Daniel Scott-Algara,Faroudy Boufassaet al. Clinical Immunology, 2014, 155 (1), pp.17-26. ⟨10.1016/j.clim.2014.07.010⟩ Article dans une revue istex hal-02322630v1
Rasv12 induces survivin/auroraB pathway conferring tumor cell apoptosis resistance Réda Hadj-Slimane,Perayot Pamonsinlapatham,Jean-Philippe Herbeuval,Christiane Garbay,Yves Lepelletieret al. Cellular Signalling, 2010, 22 (8), pp.1214-1221. ⟨10.1016/j.cellsig.2010.03.013⟩ Article dans une revue istex hal-00473108v1
Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells Renaud Colisson,Lucie Barblu,Christophe Gras,Françoise Raynaud,Reda Hadj-Slimaneet al. Blood, 2010, 115 (11), pp.2177-2185. ⟨10.1182/blood-2009-06-224741⟩ Article dans une revue hal-04249994v1
RasV12 induces Survivin/AuroraB pathway conferring tumor cell apoptosis resistance Réda Hadj-Slimane,Perayot Pamonsinlapatham,Jean-Philippe Herbeuval,Christiane Garbay,Yves Lepelletieret al. Cellular Signalling, 2010, 22 (8), pp.1214-1221. ⟨10.1016/j.cellsig.2010.03.013⟩ Article dans une revue istex hal-04250005v1
HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques Jean-Philippe Herbeuval,Jakob Nilsson,Adriano Boasso,Andrew Hardy,Monica Vaccariet al. AIDS. Official journal of the international AIDS Society, 2009, 23 (1), pp.35-40. ⟨10.1097/QAD.0b013e32831cb907⟩ Article dans une revue hal-04204741v1
HIV-1 immunopathogenesis: How good interferon turns bad Jean-Philippe Herbeuval,Gene Shearer Clinical Immunology, 2007, 123 (2), pp.121-128. ⟨10.1016/j.clim.2006.09.016⟩ Article dans une revue hal-04204725v1
HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-α Andrew Hardy,David Graham,Gene Shearer,Jean-Philippe Herbeuval Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (44), pp.17453-17458. ⟨10.1073/pnas.0707244104⟩ Article dans une revue hal-04204737v1
Differential expression of IFN-α and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients Jean-Philippe Herbeuval,Jakob Nilsson,Adriano Boasso,Andrew Hardy,Michael Kruhlaket al. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (18), pp.7000-7005. ⟨10.1073/pnas.0600363103⟩ Article dans une revue hal-04198879v1
HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells Adriano Boasso,Jean-Philippe Herbeuval,Andrew Hardy,Stephanie Anderson,Matthew Dolanet al. Blood, 2006, 109 (8), pp.3351-3359. ⟨10.1182/blood-2006-07-034785⟩ Article dans une revue hal-04204732v1
Regulation of TNF-related apoptosis-inducing ligand on primary CD4 + T cells by HIV-1: Role of type I IFN-producing plasmacytoid dendritic cells Jean-Philippe Herbeuval,Andrew Hardy,Adriano Boasso,Stephanie Anderson,Matthew Dolanet al. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 (39), pp.13974-13979. ⟨10.1073/pnas.0505251102⟩ Article dans une revue hal-04198875v1
CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis Jean-Philippe Herbeuval,Jean-Charles Grivel,Adriano Boasso,Andrew Hardy,Claire Chougnetet al. Blood, 2005, 106 (10), pp.3524-3531. ⟨10.1182/blood-2005-03-1243⟩ Article dans une revue hal-04198872v1
TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells Jean-Philippe Herbeuval,Adriano Boasso,Jean-Charles Grivel,Andrew Hardy,Stephanie Andersonet al. Blood, 2005, 105 (6), pp.2458-2464. ⟨10.1182/blood-2004-08-3058⟩ Article dans une revue hal-04198864v1
Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells Adriano Boasso,Jean-Philippe Herbeuval,Andrew Hardy,Christiana Winkler,Gene Shearer Blood, 2005, 105 (4), pp.1574-1581. ⟨10.1182/blood-2004-06-2089⟩ Article dans une revue hal-04198822v1
Recruitment of STAT3 for Production of IL-10 by Colon Carcinoma Cells Induced by Macrophage-Derived IL-6 Eric Lelievre,Claude Lambert,Michel Dy,Christian Genin,Jean-Philippe Herbeuval Journal of Immunology, 2004, 172 (7), pp.4630-4636. ⟨10.4049/jimmunol.172.7.4630⟩ Article dans une revue hal-04249987v1
Macrophages From Cancer Patients: Analysis of TRAIL, TRAIL Receptors, and Colon Tumor Cell Apoptosis Jean-Philippe Herbeuval,Claude Lambert,Odile Sabido,Michèle Cottier,Pierre Fournelet al. JNCI: Journal of the National Cancer Institute, 2003, 95 (8), pp.611-621. ⟨10.1093/jnci/95.8.611⟩ Article dans une revue hal-04198816v1

Communication dans un congrès (2)

Screening the signalling behaviour of immunomodulating compounds at CXCR4 Jean Philippe Herbeuval 19th World Congress of Basic and Clinical Pharmacology (WCP), Jul 2023, Glasgow, France. pp.670-671 Communication dans un congrès hal-04255631v1
In Vitro Functionally Selective Immunomodulator Shows Robust Efficacy in Pristane-induced Murine Lupus Model Jean Philippe Herbeuval 19th World Congress of Basic and Clinical Pharmacology (WCP), Jul 2023, Glasgow, United Kingdom. pp.561-561 Communication dans un congrès hal-04255619v1

Pré-publication, Document de travail (1)

IFN-β plasmatic levels are best predictors of muscle disease activity than IFN-α in a longitudinal cohort of patients with juvenile dermatomyositis Thomas Rj Moreau,Vincent Bondet,Juliette Ramos,Naïm Ouldali,Marie-Alexandra Alyanakianet al. 2023 Pré-publication, Document de travail pasteur-05120654v1