Jean-Philippe Pin Directeur de Recherche de classe exceptionnelle au CNRS

Identifiants chercheurs

IdHAL :

jean-philippe-pin

ORCID :

0000-0002-1423-345X

IdRef :

033123152

Présentation

Jean-Philippe Pin a obtenu son doctorat en biologie moléculaire en 1987 à l'université de Montpellier (France), en travaillant sur les récepteurs des acides aminés excitateurs, à une époque où le glutamate n'était pas encore pleinement accepté comme neurotransmetteur. Ses études l'ont amené à participer en 1985 à la découverte des récepteurs du glutamate couplés à la protéine G, connus sous le nom de récepteurs métabotropiques du glutamate. Depuis lors, il s'est concentré sur l'étude de ces fascinants récepteurs dimériques et multidomaines. À l'aide d'astuces et de tests innovants développés en collaboration avec la société CisBio, il a révélé tous les détails de leur mécanisme d'activation original, depuis la fermeture du domaine de liaison extracellulaire induite par l'agoniste jusqu'au mouvement relatif des deux sous-unités, conduisant à une interface dimérique spécifique de l'état actif permettant à une seule sous-unité d'activer les protéines G. Ces études ont été étendues à la plupart des récepteurs de la classe C. Ces études ont été étendues à la plupart des GPCRs de classe C, y compris la détection du calcium et le récepteur GABAB. Grâce à son laboratoire collaboratif établi en Chine, il a participé à la détermination de la structure cryo-EM de certains de ces récepteurs, et a révélé le mode original d'activation de la protéine G, différent de celui de tous les autres RCPG. Récemment, il a démontré l'existence de mGluR hétérodimériques dans le cerveau, ajoutant seize nouveaux mGluR possibles dans le cerveau. Ses études ont été consacrées au développement de molécules innovantes dans le but de décrypter le potentiel thérapeutique de ces cibles. Dans cette optique, il a été l'un des premiers à signaler l'existence d'agonistes inverses, ainsi que de modulateurs allostériques négatifs et positifs pour les mGluRs. Plus récemment, il a développé des outils originaux, notamment des ligands allostériques photoswitchables qui lui ont permis de démontrer le rôle du mGlu4 central dans la réponse à la douleur, ou des nanocorps allostériques capables d'améliorer le déficit cognitif dans un modèle murin de schizophrénie.En conclusion, au cours des dernières années, il a développé des approches innovantes pour étudier les récepteurs de la surface cellulaire, y compris les biocapteurs, les ligands photosensibles et les nanocorps en tant qu'outils pharmacologiques et agents thérapeutiques potentiels. Ses études ont débouché sur de nouveaux concepts dans le domaine des RCPG, tels que l'activation des récepteurs de surface cellulaire par des protéines intracellulaires, la régulation des RCPG par des modulateurs allostériques négatifs et positifs, le fonctionnement asymétrique des dimères de RCPG.

Publications

Article dans une revue (155)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease Pierre‐andré Lafon,Mireille Elodie Tsitokana,Ugo Guy Alenda,Yen‐ling Lian,Clémentine Eva Philibertet al. Advanced Science, 2026, pp.e23791. ⟨10.1002/advs.202523791⟩ Article dans une revue hal-05592922v1
Functional and structural basis of a negative allostery within GABA&lt;sub&gt;B&lt;/sub&gt; hetero-tetramers Cangsong Shen,Hongyang Ding,Shenlan Zhang,Chanjuan Xu,Binqian Zouet al. Nature Communications, In press, Online ahead of print. ⟨10.1038/s41467-026-70640-8⟩ Article dans une revue hal-05566772v1
Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HT&lt;sub&gt;2A&lt;/sub&gt; Siyu Gai,Li Lin,Jiyong Meng,Yichen Wu,Li Xueet al. Nature Communications, In press, 17 (1), pp.3303. ⟨10.1038/s41467-026-69939-3⟩ Article dans une revue hal-05536543v2
A modular click ligand-directed approach to label endogenous dopamine D1 receptors in live cells Xavier Gómez-Santacana,Marin Boutonnet,Carles Martínez-Juvés,Marta Cimadevila,Juanlo Catenaet al. Communications Chemistry, 2025, 8 (1), pp.113. ⟨10.1038/s42004-025-01504-3⟩ Article dans une revue hal-05047394v1
Triple Labeling Resolves a GPCR Intermediate State by Using Three-Color Single Molecule FRET Léo Bonhomme,Ecenaz Bilgen,Caroline Clerté,Jean-Philippe Pin,Philippe Rondardet al. Journal of the American Chemical Society, 2025, 147 (21), pp.17689-17700. ⟨10.1021/jacs.4c18364⟩ Article dans une revue hal-05079126v1
Structural characterization of five functional states of metabotropic glutamate receptor 8 Jie Zhao,Yue Deng,Zheng Xu,Chanjuan Xu,Chang Zhaoet al. Molecular Cell, 2025, 85 (18), pp.3460-3473.e6. ⟨10.1016/j.molcel.2025.08.019⟩ Article dans une revue hal-05281325v1
Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction Mathieu Oosterlaken,Angelina Rogliardo,Tatiana Lipina,Pierre-André Lafon,Mireille Elodie Tsitokanaet al. Nature, In press, 645 (8079), pp.262-270. ⟨10.1038/s41586-025-09265-8⟩ Article dans une revue hal-05213386v1
Non-canonical internalization mechanisms of mGlu receptors Marta Cimadevila,Junke Liu,Damien Maurel,Isabelle Brabet,Marine Hoscaret al. Cell Reports, 2025, 44 (8), pp.116068. ⟨10.1016/j.celrep.2025.116068⟩ Article dans une revue hal-05213663v1
Heterodimers Revolutionize the Field of Metabotropic Glutamate Receptors Kawthar Belkacemi,Philippe Rondard,Jean-Philippe Pin,Laurent Prézeau Neuroscience, 2025, 578, pp.46-58. ⟨10.1016/j.neuroscience.2024.06.013⟩ Article dans une revue (article de synthèse) hal-04766742v1
Multi-faceted roles of β-arrestins in G protein-coupled receptor endocytosis Junke Liu,Li Xue,Magalie Ravier,Floriane Eshak,Francine Acheret al. Nature Communications, 2025, 17 (1), pp.463. ⟨10.1038/s41467-025-67156-y⟩ Article dans une revue hal-05421894v1
Nanobodies: a new paradigm for brain disorder therapies Pierre-André Lafon,Laurent Prézeau,Jean-Philippe Pin,Philippe Rondard Trends in Pharmacological Sciences, 2025, 46 (11), pp.1049-1051. ⟨10.1016/j.tips.2025.10.004⟩ Article dans une revue (article de synthèse) hal-05354489v1
Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain Nunzia Cristiano,Alexandre Cabayé,Isabelle Brabet,Ralf Glatthar,Amelie Toraet al. Journal of Medicinal Chemistry, In press, 67 (14), pp.11662-11687. ⟨10.1021/acs.jmedchem.3c01924⟩ Article dans une revue hal-04569147v1
Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu2 Receptor Agonist Na Liu,Floriane Eshak,Fanny Malhaire,Isabelle Brabet,Laurent Prézeauet al. Journal of Medicinal Chemistry, 2024, 67 (2), pp.1314-1326. ⟨10.1021/acs.jmedchem.3c01811⟩ Article dans une revue hal-04385775v1
Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists Markus Staudt,Na Liu,Fanny Malhaire,Yasaman Doroudian,Laurent Prézeauet al. European Journal of Medicinal Chemistry, 2024, 266, pp.116157. ⟨10.1016/j.ejmech.2024.116157⟩ Article dans une revue hal-04415292v1
Specific pharmacological and Gi/o protein responses of some native GPCRs in neurons Chanjuan Xu,Yiwei Zhou,Yuxuan Liu,Li Lin,Peng Liuet al. Nature Communications, 2024, 15 (1), pp.1990. ⟨10.1038/s41467-024-46177-z⟩ Article dans une revue hal-04492538v1
TrkB receptor interacts with mGlu 2 receptor and mediates antipsychotic-like effects of mGlu 2 receptor activation in the mouse Clémentine Eva Philibert,Candice Disdier,Pierre-André Lafon,Alexandre Bouyssou,Mathieu Oosterlakenet al. Science Advances , 2024, 10 (4), pp.eadg1679. ⟨10.1126/sciadv.adg1679⟩ Article dans une revue hal-04429823v1
Absence of calcium-sensing receptor basal activity due to inter-subunit disulfide bridges Shumin Ma,Xueliang Yin,Jean-Philippe Pin,Philippe Rondard,Ping Yiet al. Communications Biology, 2024, 7 (1), pp.501. ⟨10.1038/s42003-024-06189-3⟩ Article dans une revue hal-04569775v1
Structural basis of orientated asymmetry in a mGlu heterodimer Weizhu Huang,Nan Jin,Jia Guo,Cangsong Shen,Chanjuan Xuet al. Nature Communications, 2024, 15 (1), pp.10345. ⟨10.1038/s41467-024-54744-7⟩ Article dans une revue hal-04819462v1
Epitope Identification of an mGlu5 Receptor Nanobody Using Physics-Based Molecular Modeling and Deep Learning Techniques Floriane Eshak,Léo Pion,Pauline Scholler,Damien Nevoltris,Patrick Chameset al. Journal of Chemical Information and Modeling, 2024, 64 (11), pp.4436-4461. ⟨10.1021/acs.jcim.3c01620⟩ Article dans une revue hal-04723363v1
Different EGF ‐induced receptor dimer conformations for signaling and internalization Jordi Haubrich,Jurriaan Zwier,Fabienne Charrier-Savournin,Laurent Prézeau,Jean‐philippe Pin FASEB Journal, 2024, 38 (1), pp.e23356. ⟨10.1096/fj.202301209R⟩ Article dans une revue hal-04472295v1
Asymmetric activation of dimeric GABA B and metabotropic glutamate receptors Lei Liu,Lin Li,Cangsong Shen,Philippe Rondard,Jean-Philippe Pinet al. American Journal of Physiology - Cell Physiology, 2023, 325 (1), pp.C79-C89. ⟨10.1152/ajpcell.00150.2022⟩ Article dans une revue hal-04733117v1
Concerted conformational changes control metabotropic glutamate receptor activity Nathalie Lecat-Guillet,Robert Quast,Hongkang Liu,Emmanuel Bourrier,Thor Mølleret al. Science Advances , 2023, 9 (22), pp.eadf1378. ⟨10.1126/sciadv.adf1378⟩ Article dans une revue hal-04121751v1
Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity Pascal Dominic Rem,Vita Sereikaite,Diego Fernández-Fernández,Sebastian Reinartz,Daniel Ulrichet al. eLife, 2023, 12, pp.e82082. ⟨10.7554/eLife.82082⟩ Article dans une revue hal-04710184v1
Targeting the Brain with Single-Domain Antibodies: Greater Potential Than Stated So Far? Mireille Elodie Tsitokana,Pierre-André Lafon,Laurent Prézeau,Jean-Philippe Pin,Philippe Rondard International Journal of Molecular Sciences, 2023, 24 (3), pp.2632. ⟨10.3390/ijms24032632⟩ Article dans une revue (article de synthèse) hal-03991195v1
Dissecting metabotropic glutamate receptor activation by single molecule FRET using minimally invasive labeling strategies Leo Bonhomme,Robert Quast,Nathalie Lecat-Guillet,Jean-Philippe Pin,Philippe Rondardet al. Biophysical Journal, 2023, 122 (3), pp.58a. ⟨10.1016/j.bpj.2022.11.521⟩ Article dans une revue hal-04598517v1
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors Stephen Alexander,Arthur Christopoulos,Anthony Davenport,Eamonn Kelly,Alistair Mathieet al. British Journal of Pharmacology, 2023, 180 (S2), pp.S23-S144. ⟨10.1111/bph.16177⟩ Article dans une revue hal-04858591v1
Structural basis of the activation of metabotropic glutamate receptor 3 Wei Fang,Fan Yang,Chanjuan Xu,Shenglong Ling,Li Linet al. Cell Research, 2022, 32 (7), pp.695-698. ⟨10.1038/s41422-022-00623-z⟩ Article dans une revue hal-03603715v1
Nanobody-based sensors reveal a high proportion of mGlu heterodimers in the brain Jiyong Meng,Chanjuan Xu,Pierre-André Lafon,Salomé Roux,Michaël Mathieuet al. Nature Chemical Biology, 2022, 18, pp.894-903. ⟨10.1038/s41589-022-01050-2⟩ Article dans une revue hal-03699580v1
Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor Junke Liu,Hengmin Tang,Chanjuan Xu,Shengnan Zhou,Xunying Zhuet al. Nature Communications, 2022, 13 (1), pp.6365. ⟨10.1038/s41467-022-34056-4⟩ Article dans une revue hal-03837051v1
SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein‐coupled receptor kinase 3 signalosome Matej Gazdarica,Judith Noda,Oleh Durydivka,Vendula Novosadova,Ken Mackieet al. Journal of Neurochemistry, 2022, 160 (6), pp.625-642. ⟨10.1111/jnc.15569⟩ Article dans une revue hal-03761588v1
Metabotropic glutamate receptor orthosteric ligands and their binding sites Francine Acher,Alexandre Cabayé,Floriane Eshak,Anne Goupil-Lamy,Jean-Philippe Pin Neuropharmacology, 2022, 204, pp.108886. ⟨10.1016/j.neuropharm.2021.108886⟩ Article dans une revue hal-04712201v1
( S )-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist Christian Poulie,Younes Larsen,Cindie Leteneur,Gaël Barthet,Walden Bjørn-Yoshimotoet al. ACS Chemical Neuroscience, 2022, 13 (10), pp.1580-1587. ⟨10.1021/acschemneuro.2c00162⟩ Article dans une revue hal-03659473v1
Chronic sodium bromide treatment relieves autistic-like behavioral deficits in three mouse models of autism Cécile Derieux,Audrey Léauté,Agathe Brugoux,Déborah Jaccaz,Claire Terrieret al. Neuropsychopharmacology, 2022, 47 (9), pp.1680-1692. ⟨10.1038/s41386-022-01317-1⟩ Article dans une revue hal-03647444v1
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors Stephen Alexander,Arthur Christopoulos,Anthony Davenport,Eamonn Kelly,Alistair Mathieet al. British Journal of Pharmacology, 2021, 178 (S1), pp.e0243333. ⟨10.1111/bph.15538⟩ Article dans une revue hal-03875300v1
Structural basis of GABAB receptor–Gi protein coupling Cangsong Shen,Chunyou Mao,Chanjuan Xu,Nan Jin,Huibing Zhanget al. Nature, 2021, 594 (7864), pp.594-598. ⟨10.1038/s41586-021-03507-1⟩ Article dans une revue hal-03218736v1
The GABA B receptor mediates neuroprotection by coupling to G 13 Yunyun Wang,Siyu Gai,Wenhua Zhang,Xuetao Huang,Shumin Maet al. Science Signaling, 2021, 14 (705), pp.eaaz4112. ⟨10.1126/scisignal.aaz4112⟩ Article dans une revue hal-03394399v1
G protein‐coupled receptors can control the Hippo/YAP pathway through Gq signaling Diana Zindel,Patrick Mensat,Claire Vol,Zeinab Homayed,Fabienne Charrier‐savourninet al. FASEB Journal, 2021, 35 (7), pp.e21668. ⟨10.1096/fj.202002159R⟩ Article dans une revue hal-03263933v1
A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers Jordi Haubrich,Joan Font,Robert Quast,Anne Goupil-Lamy,Pauline Scholleret al. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (33), pp.e2105848118. ⟨10.1073/pnas.2105848118⟩ Article dans une revue hal-03322348v1
Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface Lei Liu,Zhiran Fan,Xavier Rovira,Li Xue,Salomé Rouxet al. eLife, 2021, 10, pp.e70188. ⟨10.7554/eLife.70188⟩ Article dans une revue hal-03738955v1
Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state Anne-Marinette Cao,Robert B Quast,Fataneh Fatemi,Philippe Rondard,Jean-Philippe Pinet al. Nature Communications, 2021, 12 (1), pp.5426. ⟨10.1038/s41467-021-25620-5⟩ Article dans une revue hal-03352901v2
GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12 Bo Wei,Yini Zhu,Peng Yang,Yong Han,Suyun Wanget al. iScience, 2021, 24 (11), pp.103311. ⟨10.1016/j.isci.2021.103311⟩ Article dans une revue hal-03432362v1
Structures of human mGlu2 and mGlu7 homo- and heterodimers Juan Du,Dejian Wang,Hongcheng Fan,Chanjuan Xu,Linhua Taiet al. Nature, 2021, 594 (7864), pp.589-593. ⟨10.1038/s41586-021-03641-w⟩ Article dans une revue hal-03269110v1
Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations Chady Nasrallah,Giuseppe Cannone,Julie Briot,Karine Rottier,Alice Berizziet al. Cell Reports, 2021, 36 (9), pp.109648. ⟨10.1016/j.celrep.2021.109648⟩ Article dans une revue hal-03340751v1
Illuminating the allosteric modulation of the calcium-sensing receptor Hongkang Liu,Ping Yi,Wenjing Zhao,Yuling Wu,Francine Acheret al. Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (35), pp.21711-21722. ⟨10.1073/pnas.1922231117⟩ Article dans une revue hal-02933760v1
Structural basis of metabotropic GABA receptor activation Hamidreza Shaye,Andrii Ishchenko,Jordy Homing Lam,Gye Won Han,Li Xueet al. Nature, 2020, 584 (7820), pp.298-303. ⟨10.1038/s41586-020-2408-4⟩ Article dans une revue hal-03065675v1
D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson’s disease Irene Sebastianutto,Elise Goyet,Laura Andreoli,Joan Font-Ingles,David Moreno-Delgadoet al. Journal of Clinical Investigation, 2020, 130 (3), pp.1168 - 1184. ⟨10.1172/JCI126361⟩ Article dans une revue hal-02476033v1
Structural basis for distinct quality control mechanisms of Drosophila and mammalian GABAB receptor Shenglan Zhang,Li Xue,Xuehui Liu,Xuejun Cai Zhang,Rui Zhouet al. FASEB Journal, 2020, 34 (12), pp.16348-16363. ⟨10.1096/fj.202001355RR⟩ Article dans une revue hal-03065658v1
Rearrangement of the transmembrane domain interfaces associated with the activation 1 of a GPCR hetero-oligomer 2 3 Li Xue,Qian Sun,Han Zhao,Xavier Rovira,Siyu Gaiet al. Nature Communications, 2019, 10 (1), pp.2765. ⟨10.1038/s41467-019-10834-5⟩ Article dans une revue hal-02398123v1
Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23 Maya Kansara,Kristian Thomson,Puiyi Pang,Aurélie Dutour,Lisa Mirabelloet al. Cancer Discovery, 2019, 9 (11), pp.1511-1519. ⟨10.1158/2159-8290.CD-19-0154⟩ Article dans une revue hal-02398127v1
LSP5-2157 a new inhibitor of vesicular glutamate transporters Odile Poirel,Lauren E Mamer,Melissa A Herman,Marie Arnulf-Kempcke,Myriam Kervernet al. Neuropharmacology, 2019, 164, pp.107902. ⟨10.1016/j.neuropharm.2019.107902⟩ Article dans une revue hal-03043497v1
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors Stephen Alexander,Arthur Christopoulos,Anthony P Davenport,Eamonn Kelly,Alistair Mathieet al. British Journal of Pharmacology, 2019, 176 (S1), pp.S21-S141. ⟨10.1111/bph.14748⟩ Article dans une revue hal-02388696v1
Non-classical ligand-independent regulation of Go protein by an orphan Class C GPCR Mariana Hajj,Teresa de Vita,Claire Vol,Charlotte Renassia,Jean-Charles Bolognaet al. Molecular Pharmacology, 2019, 96 (2), pp.233-246. ⟨10.1124/mol.118.113019⟩ Article dans une revue hal-02396282v1
Context-Dependent Signaling of CXC Chemokine Receptor 4 and Atypical Chemokine Receptor 3 Joyce Heuninck,Cristina Perpiñá Viciano,Ali Işbilir,Birgit Caspar,Davide Capoferriet al. Molecular Pharmacology, 2019, 96 (6), pp.778-793. ⟨10.1124/mol.118.115477⟩ Article dans une revue hal-02389610v1
GPCR interaction as a possible way for allosteric control between receptors Jean-Philippe Pin,Julie Kniazeff,Laurent Prézeau,Jiang-Feng Liu,Philippe Rondard Molecular and Cellular Endocrinology, 2019, 486, pp.89-95. ⟨10.1016/j.mce.2019.02.019⟩ Article dans une revue (article de synthèse) hal-02396289v1
Allosteric interactions between GABA B1 subunits control orthosteric binding sites occupancy within GABA B oligomers Gregory D Stewart,Laetitia Comps-Agrar,Lenea Blanc Nørskov-Lauritsen,Jean-Philippe Pin,Julie Kniazeff Neuropharmacology, 2018, 136, pp.92-101. ⟨10.1016/j.neuropharm.2017.12.042⟩ Article dans une revue hal-02398132v1
Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4 Charleine Zussy,X. Gomez-Santacana,Xavier Rovira,Dimitri de Bundel,S. Ferrazzoet al. Molecular Psychiatry, 2018, 23 (3), pp.509-520. ⟨10.1038/mp.2016.223⟩ Article dans une revue hal-02073218v1
Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs Chady Nasrallah,Karine Rottier,Romain Marcellin,Vincent Compan,J. Fontet al. Scientific Reports, 2018, 8 (1), pp.4407. ⟨10.1038/s41598-018-22729-4⟩ Article dans une revue hal-02073194v1
Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice Cyril Rivat,Chamroeun Sar,Ilana Mechaly,J.P. Leyris,Lucie Diouloufetet al. Nature Communications, 2018, 9 (1), pp.1042. ⟨10.1038/s41467-018-03496-2⟩ Article dans une revue hal-02158159v1
Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite® assays Abderazak Belhocine,Pietro Veglianese,Candide Hounsou,Elodie Dupuis,Francine C. Acheret al. Neuropharmacology, 2018, 140, pp.233-245. ⟨10.1016/j.neuropharm.2018.07.032⟩ Article dans une revue istex hal-02388698v1
Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites Chelliah Selvam,Isabelle Lemasson,Isabelle Brabet,Nadia Oueslati,Berin Karamanet al. Journal of Medicinal Chemistry, 2018, 61 (5), pp.1969-1989. ⟨10.1021/acs.jmedchem.7b01438⟩ Article dans une revue hal-02018007v1
Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3 Amélie S. Tora,Xavier Rovira,Anne-Marinette Cao,Alexandre Cabaye,Linnea Olofssonet al. Neuropharmacology, 2018, 140, pp.275-286. ⟨10.1016/j.neuropharm.2018.08.011⟩ Article dans une revue hal-02346230v1
Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics Thor C Møller,Jérôme Hottin,Caroline Clerté,Jurriaan M. Zwier,Thierry Durrouxet al. Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-28682-6⟩ Article dans une revue hal-02398134v1
HTS-compatible FRET-based conformational sensors clarify membrane receptor activation Pauline Scholler,David Moreno-Delgado,Nathalie Lecat-Guillet,Etienne Doumazane,Carine Monnieret al. Nature Chemical Biology, 2017, 13 (4), pp.372-380. ⟨10.1038/nchembio.2286⟩ Article dans une revue hal-02075211v1
FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABA B Receptor Nathalie Lecat-Guillet,Carine Monnier,Xavier Rovira,Julie Kniazeff,Laurent Lamarqueet al. Cell Chemical Biology, 2017, 24 (3), pp.360-370. ⟨10.1016/j.chembiol.2017.02.011⟩ Article dans une revue hal-02072973v1
From the Promiscuous Asenapine to Potent Fluorescent Ligands Acting at a Series of Aminergic G-Protein-Coupled Receptors Candide Hounsou,Corinne Baehr,Vincent Gasparik,Doria Alili,Abderazak Belhocineet al. Journal of Medicinal Chemistry, 2017, 61 (1), pp.174-188. ⟨10.1021/ACS.JMEDCHEM.7B01220⟩ Article dans une revue hal-02366277v1
Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand James Dalton,Jean-Philippe Pin,Jesús Giraldo Scientific Reports, 2017, 7 (1), pp.4944. ⟨10.1038/s41598-017-05095-5⟩ Article dans une revue hal-02058681v1
Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer Junke Liu,Zongyong Zhang,David Moreno-Delgado,James Ar Dalton,Xavier Roviraet al. eLife, 2017, 6, ⟨10.7554/eLife.26985⟩ Article dans une revue hal-02073040v1
RgIA4 potently blocks mouse $\alpha$9$\alpha$10 nAChRs and provides long lasting protection against oxaliplatin-induced cold allodynia Sean Christensen,Arik Hone,Isabelle Roux,Julie Kniazeff,Jean-Philippe Pinet al. Frontiers in Cellular Neuroscience, 2017, 11, pp.219. ⟨10.3389/fncel.2017.00219⟩ Article dans une revue hal-03363884v1
Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu 5 negative allosteric modulation Xavier Gómez-Santacana,James Dalton,Xavier Rovira,Jean-Philippe Pin,Cyril Goudetet al. European Journal of Medicinal Chemistry, 2017, 127, pp.567-576. ⟨10.1016/j.ejmech.2017.01.013⟩ Article dans une revue hal-02066019v1
Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals Xavier Gómez-Santacana,Silvia Pittolo,Xavier Rovira,Marc Lopez,Charleine Zussyet al. ACS Central Science, 2017, 3 (1), pp.81-91. ⟨10.1021/acscentsci.6b00353⟩ Article dans une revue hal-02066097v1
Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells David Moreno-Delgado,Thor C Møller,Jeanne Ster,Jesús Giraldo,Damien Maurelet al. eLife, 2017, 6, ⟨10.7554/eLife.25233⟩ Article dans une revue hal-02073201v1
Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges Mohammed Akli Ayoub,Pascale Crépieux,Markus Koglin,Marc Parmentier,Jean-Philippe Pinet al. mAbs, 2017, pp.1-24. ⟨10.1080/19420862.2017.1325052⟩ Article dans une revue hal-01604272v1
Class C G protein-coupled receptors: reviving old couples with new partners Thor C Møller,David Moreno-Delgado,Jean-Philippe Pin,Julie Kniazeff Biophysics Reports, 2017, 3 (4-6), pp.57-63. ⟨10.1007/s41048-017-0036-9⟩ Article dans une revue hal-02073162v1
Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator Joan Font,Marc López-Cano,Serena Notartomaso,Pamela Scarselli,Paola Di Pietroet al. eLife, 2017, 6, ⟨10.7554/elife.23545.001⟩ Article dans une revue hal-03549950v1
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation Pauline Scholler,Damien Nevoltris,Dimitri de Bundel,Simon Bossi,David Moreno-Delgadoet al. Nature Communications, 2017, 8 (1), pp.1967. ⟨10.1038/s41467-017-01489-1⟩ Article dans une revue hal-01672805v2
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New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III Tri H. V. Huynh,Mette N. Erichsen,Amélie S. Tora,Cyril Goudet,Emmanuelle Sagotet al. Journal of Medicinal Chemistry, 2016, 59, pp.914-924. ⟨10.1021/acs.jmedchem.5b01333⟩ Article dans une revue hal-01288609v1
Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling Diana Zindel,S. Engel,A. R. Bottrill,Jean-Philippe Pin,Laurent Prézeauet al. Biochemical Journal, 2016, 473 (22), pp.4173--4192. ⟨10.1042/BCJ20160740⟩ Article dans une revue hal-01940960v1
Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective James Dalton,Isaias Lans,Xavier Rovira,Fanny Malhaire,Xavier Gómez-Santacanaet al. Current Neuropharmacology, 2016, 14 (5), pp.441-454. ⟨10.2174/1570159x13666150407231417⟩ Article dans une revue hal-02448289v1
Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors Xavier Rovira,Fanny Malhaire,Pauline Scholler,Jordi Rodrigo,P. Gonzalez-Bulneset al. FASEB Journal, 2015, 29 (1), pp.116--30. ⟨10.1096/fj.14-257287⟩ Article dans une revue hal-01943324v1
Determination of the absolute configuration of phosphinic analogues of glutamate Bruno Commare,Delphine Rigault,Isabelle Lemasson,Patrick Deschamps,Alain Tomaset al. Organic & Biomolecular Chemistry, 2015, 13 (4), pp.1106-1112. ⟨10.1039/C4OB01960A⟩ Article dans une revue hal-02268872v1
Introduction J. Bousquet,R. Bourret,T. Camuzat,P Augé,P. Domyet al. La Presse Médicale, 2015, 44, ⟨10.1016/j.lpm.2015.07.014⟩ Article dans une revue istex hal-02565513v1
Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats V. Fernandez-Duenas,J. J. Taura,Martin Cottet,M. Gomez-Soler,M. Lopez-Canoet al. Disease Models & Mechanisms, 2015, 8 (1), pp.57--63. ⟨10.1242/dmm.018143⟩ Article dans une revue hal-01950131v1
Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer Candide Hounsou,Jean-François Margathe,Nadia Oueslati,Abderazak Belhocine,Elodie Dupuiset al. ACS Chemical Biology, 2015, 10 (2), pp.466--74. ⟨10.1021/cb5007568⟩ Article dans une revue hal-01950133v1
Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers Pavel Ivashkin,Gérald Lemonnier,Amélie S. Tora,Jean-Philippe Pin,Cyril Goudetet al. Bioorganic and Medicinal Chemistry Letters, 2015, 25 (12), pp.2523-2526. ⟨10.1016/j.bmcl.2015.04.043⟩ Article dans une revue hal-01180138v1
Dynamics and modulation of metabotropic glutamate receptors Philippe Rondard,Jean-Philippe Pin Current Opinion in Pharmacology, 2015, 20, pp.95--101. ⟨10.1016/j.coph.2014.12.001⟩ Article dans une revue hal-01943325v1
Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer Li Xue,Xavier Rovira,Pauline Scholler,Han Zhao,Jianfeng Liuet al. Nature Chemical Biology, 2015, 11 (2), pp.134--40. ⟨10.1038/nchembio.1711⟩ Article dans une revue hal-01943326v1
Allosteric modulation of metabotropic glutamate receptors by chloride ions Amélie S. Tora,Xavier Rovira,Ibrahima Dione,Hugues-Olivier Bertrand,Isabelle Brabetet al. FASEB Journal, 2015, 29 (10), pp.4174-4188. ⟨10.1096/fj.14-269746⟩ Article dans une revue hal-02065116v1
Editorial overview: Neurosciences: Targeting glutamatergic signaling in CNS diseases: new hopes? Pierre Paoletti,Jean-Philippe Pin Current Opinion in Pharmacology, 2015, 20, pp.iv-vi. ⟨10.1016/j.coph.2015.01.001⟩ Article dans une revue istex hal-02065120v1
Homogeneous time-resolved fluorescence-based assay to monitor extracellular signal-regulated kinase signaling in a high-throughput format Mohammed Akli Ayoub,Julien Trebaux,Julie Vallaghe,Fabienne Charrier-Savournin,Khaled Al-Hosainiet al. Frontiers in Endocrinology, 2014, 5, pp.94. ⟨10.3389/fendo.2014.00094⟩ Article dans une revue hal-01943335v1
Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy Linnea Olofsson,S. Felekyan,Etienne Doumazane,Pauline Scholler,Ludovic Fabreet al. Nature Communications, 2014, 5, pp.5206. ⟨10.1038/ncomms6206⟩ Article dans une revue hal-01943332v1
Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila. Marianne Bjordal,Nathalie Arquier,Julie Kniazeff,Jean-Philippe Pin,Pierre Léopold Cell, 2014, 156 (3), pp.510-21. ⟨10.1016/j.cell.2013.12.024⟩ Article dans une revue hal-00968719v1
Biased signaling through G-protein-coupled PROKR2 receptors harboring missense mutations Oualid Sbai,Carine Monnier,Catherine Dode,Jean-Philippe Pin,Jean-Pierre Hardelinet al. FASEB Journal, 2014, 28 (8), pp.3734--44. ⟨10.1096/fj.13-243402⟩ Article dans une revue hal-01942940v1
Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor Chanjuan Xu,Wenhua Zhang,Philippe Rondard,Jean-Philippe Pin,Jianfeng Liu Frontiers in Pharmacology, 2014, 5, pp.12. ⟨10.3389/fphar.2014.00012⟩ Article dans une revue hal-01942936v1
Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor Xavier Rovira,Youssef Harrak,Ana Trapero,Patricia Gonzalez-Bulnes,Fanny Malhaireet al. ChemMedChem, 2014, 9 (12), pp.2685--98. ⟨10.1002/cmdc.201402190⟩ Article dans une revue istex hal-01943327v1
An allosteric modulator to control endogenous G protein-coupled receptors with light S. Pittolo,X. Gomez-Santacana,K. Eckelt,Xavier Rovira,J. Daltonet al. Nature Chemical Biology, 2014, 10 (10), pp.813--5. ⟨10.1038/nchembio.1612⟩ Article dans une revue hal-01942934v1
The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and betaarrestin Sylvain Armando,Julie Quoyer,Viktorya Lukashova,Arhamatoulaye Maiga,Yann Percherancieret al. FASEB Journal, 2014, 28 (10), pp.4509--23. ⟨10.1096/fj.13-242446⟩ Article dans une revue hal-01950128v1
G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Sergi Ferré,Vicent Casadó,Lakshmi A. Devi,Marta Filizola,Ralf Jockerset al. Pharmacological Reviews, 2014, 66 (2), pp.413-34. ⟨10.1124/pr.113.008052⟩ Article dans une revue inserm-01067990v1
Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor Bruno Vilar,Jérôme Busserolles,Bing Ling,Sophie Laffray,Lauriane Ulmannet al. Journal of Neuroscience, 2013, 33 (48), pp.18951-18965. ⟨10.1523/JNEUROSCI.1221-13.2013⟩ Article dans une revue hal-02448295v1
Interaction of Protease-Activated Receptor 2 with G Proteins and beta-Arrestin 1 Studied by Bioluminescence Resonance Energy Transfer Mohammed Akli Ayoub,Jean-Philippe Pin Frontiers in Endocrinology, 2013, 4, pp.196. ⟨10.3389/fendo.2013.00196⟩ Article dans une revue hal-01984750v1
Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease Marianne Amalric,S. Lopez,C. Goudet,G. Fisone,G. Battagliaet al. Neuropharmacology, 2013, 66 (SI), pp.53-64. ⟨10.1016/j.neuropharm.2012.05.026⟩ Article dans une revue istex hal-01384098v1
Stability of GABA B receptor oligomers revealed by dual TR‐FRET and drug‐induced cell surface targeting Laëtitia Comps‐agrar,Julie Kniazeff,Carsten Brock,Eric Trinquet,Jean-Philippe Pin FASEB Journal, 2012, 26 (8), pp.3430-3439. ⟨10.1096/fj.12-203646⟩ Article dans une revue hal-03363950v1
Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4. Gérald Lemonnier,Cédric Lion,Jean-Charles Quirion,Jean-Philippe Pin,Cyril Goudetet al. Bioorganic and Medicinal Chemistry, 2012, 20 (15), pp.4716-26. ⟨10.1016/j.bmc.2012.06.006⟩ Article dans une revue istex hal-00996602v1
Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors F. Fazio,L. Lionetto,G. Molinaro,H. Bertrand,F. Acheret al. Molecular Pharmacology, 2012, 81 (5), pp.643-656. ⟨10.1124/mol.111.074765⟩ Article dans une revue hal-02448364v1
Des dimères et des oligomères de récepteurs couplés aux protéines G, oui mais pourquoi ? Julie Kniazeff,Jean-Philippe Pin Médecine/Sciences, 2012, 28 (10), pp.858-863. ⟨10.1051/medsci/20122810014⟩ Article dans une revue hal-03363918v1
Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2 Yong Geng,Dazhi Xiong,Lidia Mosyak,David Malito,Julie Kniazeffet al. Nature Neuroscience, 2012, 15 (7), pp.970-978. ⟨10.1038/nn.3133⟩ Article dans une revue hal-03363943v1
A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. Cyril Goudet,Bruno Vilar,Tiphanie Courtiol,Thierry Deltheil,Thomas Bessironet al. FASEB Journal, 2012, 26 (4), pp.1682-93. ⟨10.1096/fj.11-195941⟩ Article dans une revue hal-01182946v1
A new Selective Metabotropic Glutamate Receptor type 4 Agonist Reveals New ways to Develop Subtype Selective Orthosteric Ligands with Potential Therapeutic Effects Cyril Goudet,Bruno Vilar,Tiphanie Courtiol,Thierry Deltheil,Thomas Bessironet al. Current Neuropharmacology, 2011, 9 (1), pp.26 Article dans une revue hal-01384798v1
G Protein Activation by Serotonin Type 4 Receptor Dimers: evidence that turning on two protomers is more efficient. Lucie P. Pellissier,Gaël Barthet,Florence Gaven,Elisabeth Cassier,Eric Trinquetet al. Journal of Biological Chemistry, 2011, 286 (12), pp.9985-9997. ⟨10.1074/jbc.M110.201939⟩ Article dans une revue hal-02482879v1
A Virtual Screening Hit Reveals New Possibilities for Developing Group III Metabotropic Glutamate Receptor Agonists Chelliah Selvam,Nadia Oueslati,Isabelle Lemasson,Isabelle Brabet,Delphine Rigaultet al. Journal of Medicinal Chemistry, 2010, 53 (7), pp.2797-2813. ⟨10.1021/jm901523t⟩ Article dans une revue hal-05346713v1
Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment D. Cuomo,G. Martella,E. Barabino,P. Platania,D. Vitaet al. Journal of Neurochemistry, 2009, 109, pp.1096-1105 Article dans une revue hal-00409236v1
IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels Anthony J. Harmar,Rebecca A. Hills,Edward M. Rosser,Martin Jones,O. Peter Bunemanet al. Nucleic Acids Research, 2009, 37, pp.D680-D685. ⟨10.1093/nar/gkn728⟩ Article dans une revue hal-02667062v1
Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism C. Beurrier,S. Lopez,D. Revy,C. Selvam,C. Goudetet al. FASEB Journal, 2009, 23, pp.3619-3628 Article dans une revue hal-00582954v1
Is metabotropic glutamate receptor mGlu4R a good target to treat Parkinson's disease symptoms? Design and evaluation of potent and selective agonists Isabelle A. Lemasson,Chelliah Selvam,Nadia Oueslati,Isabelle Brabet,Tiphanie Courtiolet al. Abstracts of Papers of the American Chemical Society, 2009, 238 Article dans une revue hal-01384832v1
A novel series of group III metabotropic glutamate receptor (mGluR) agonists Francine C. Acher,C. Selvam,N. Triballeau,N. Oueslati,I. Lemassonet al. Abstracts of Papers of the American Chemical Society, 2009, 237 Article dans une revue hal-01384834v1
Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells. Jiri Kumpost,Zdenka Syrova,Lenka Kulihova,Daniela Frankova,Jean-Charles Bolognaet al. Neuropharmacology, 2008, 55 (4), pp.409-18. ⟨10.1016/j.neuropharm.2008.06.073⟩ Article dans une revue inserm-00319023v1
N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. Yelin Chen,Cyril Goudet,Jean-Philippe Pin,P Jeffrey Conn Molecular Pharmacology, 2008, 73 (3), pp.909-18. ⟨10.1124/mol.107.040097⟩ Article dans une revue inserm-00318958v1
Modeling the binding and function of metabotropic glutamate receptors. Xavier Rovira,David Roche,Juan Serra,Julie Kniazeff,Jean-Philippe Pinet al. Journal of Pharmacology and Experimental Therapeutics, 2008, 325 (2), pp.443-56. ⟨10.1124/jpet.107.133967⟩ Article dans une revue hal-00319020v1
Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning. Philippe Rondard,Siluo Huang,Carine Monnier,Haijun Tu,Bertrand Blanchardet al. EMBO Journal, 2008, 27 (9), pp.1321-1332. ⟨10.1038/emboj.2008.64⟩ Article dans une revue hal-00318880v1
Cell surface protein-protein interaction analysis with combined time-resolved FRET and snap-tag technologies: application to GPCR oligomerization Damien Maurel,Laetitia Comps-Agrar,Carsten Brock,Marie-Laure Rives,Emmanuel Bourrieret al. Nature Methods, 2008, 5 (6), pp.561. ⟨10.1038/nmeth.1213⟩ Article dans une revue hal-00318856v1
Amino-pyrrolidine tricarboxylic acids give new insight into group III metabotropic glutamate receptor activation mechanism. Mélanie Frauli,Nadia Hubert,Stephan Schann,Nicolas Triballeau,Hugues-Olivier Bertrandet al. Molecular Pharmacology, 2007, 71 (3), pp.704-12. ⟨10.1124/mol.106.030254⟩ Article dans une revue inserm-00318866v1
Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons. Haijun Tu,Philippe Rondard,Chanjuan Xu,Federica Bertaso,Fangli Caoet al. Cellular Signalling, 2007, 19 (9), pp.1996-2002. ⟨10.1016/j.cellsig.2007.05.004⟩ Article dans une revue hal-00319022v1
Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells. Mohammed Akli Ayoub,Damien Maurel,Virginie Binet,Michel Fink,Laurent Prézeauet al. Molecular Pharmacology, 2007, 71 (5), pp.1329-40. ⟨10.1124/mol.106.030304⟩ Article dans une revue hal-00318930v1
Activation of a Dimeric Metabotropic Glutamate Receptor by Inter-Subunit Rearrangement Carsten Brock,Nadia Oueslati,Stéphan Soler,Laure Boudier,Philippe Rondardet al. Journal of Biological Chemistry, 2007, 282 (45), pp.33000. ⟨10.1074/jbc.M702542200⟩ Article dans une revue hal-00318871v1
Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Yelin Chen,Yi Nong,Cyril Goudet,Kamondanai Hemstapat,Tomas de Pauliset al. Molecular Pharmacology, 2007, 71 (5), pp.1389-98. ⟨10.1124/mol.106.032425⟩ Article dans une revue inserm-00319012v1
Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors. Virginie Binet,Béatrice Duthey,Jennifer Lecaillon,Claire Vol,Julie Quoyeret al. Journal of Biological Chemistry, 2007, 282 (16), pp.12154-63. ⟨10.1074/jbc.M611071200⟩ Article dans une revue inserm-00318820v1
Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists. Pauline Sibille,Sébastien Lopez,Isabelle Brabet,Ornella Valenti,Nadia Oueslatiet al. Journal of Medicinal Chemistry, 2007, 50 (15), pp.3585-95. ⟨10.1021/jm070262c⟩ Article dans une revue istex inserm-00318976v1
Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain Cyril Goudet,Eric Chapuy,Abdelkrim Alloui,Francine Acher,Jean-Philippe Pinet al. Pain, 2007, 137 (1), pp.112-124. ⟨10.1016/j.pain.2007.08.020⟩ Article dans une revue inserm-00318859v1
L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency. Chelliah Selvam,Cyril Goudet,Nadia Oueslati,Jean-Philippe Pin,Francine C. Acher Journal of Medicinal Chemistry, 2007, 50 (19), pp.4656-64. ⟨10.1021/jm070400y⟩ Article dans une revue istex inserm-00318965v1
Among the twenty classical L-amino acids, only glutamate directly activates metabotropic glutamate receptors. Mélanie Frauli,Pascal Neuville,Claire Vol,Jean-Philippe Pin,Laurent Prézeau Neuropharmacology, 2006, 50 (2), pp.245-53. ⟨10.1016/j.neuropharm.2005.09.016⟩ Article dans une revue inserm-00318879v1
D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation. Eric Trinquet,Michel Fink,Hervé Bazin,Florence Grillet,Fabrice Maurinet al. Analytical Biochemistry, 2006, 358 (1), pp.126-35. ⟨10.1016/j.ab.2006.08.002⟩ Article dans une revue istex inserm-00318996v1
Asymmetry conformational changes in a GPCR dimer controlled by G-proteins Marjorie Damian,Aimée Martin,Danielle Mesnier,Jean-Philippe Pin,Jean-Louis Banères EMBO Journal, 2006, 25 (24), pp.5693-5702. ⟨10.1038/sj.emboj.7601449⟩ Article dans une revue hal-00176784v1
Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15. Christelle Masdeu,Hélène Faure,Josée Coulombe,Angèle Schoenfelder,André Mannet al. Biochemical and Biophysical Research Communications, 2006, 349 (2), pp.471-9. ⟨10.1016/j.bbrc.2006.07.216⟩ Article dans une revue istex hal-00105551v1
Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR. Veronika Hlavackova,Cyril Goudet,Julie Kniazeff,Alice Zikova,Damien Maurelet al. EMBO Journal, 2005, 24 (3), pp.499-509. ⟨10.1038/sj.emboj.7600557⟩ Article dans une revue inserm-00318934v1
Allosteric functioning of dimeric class C G-protein-coupled receptors. Jean-Philippe Pin,Julie Kniazeff,Jianfeng Liu,Virginie Binet,Cyril Goudetet al. FEBS Journal, 2005, 272, pp.2947-55. ⟨10.1111/j.1742-4658.2005.04728.x⟩ Article dans une revue inserm-00094959v1
Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators. Cyril Goudet,Julie Kniazeff,Veronika Hlavackova,Fanny Malhaire,Damien Maurelet al. Journal of Biological Chemistry, 2005, 280 (26), pp.24380-5. ⟨10.1074/jbc.M502642200⟩ Article dans une revue inserm-00318925v1
Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3. Carsten Brock,Laure Boudier,Damien Maurel,Jaroslav Blahos,Jean-Philippe Pin Molecular Biology of the Cell, 2005, 16 (12), pp.5572-8. ⟨10.1091/mbc.E05-05-0400⟩ Article dans une revue hal-00318967v2
Cell surface detection of membrane protein interaction with homogeneous time-resolved fluorescence resonance energy transfer technology. Damien Maurel,Julie Kniazeff,Gérard Mathis,Eric Trinquet,Jean-Philippe Pinet al. Analytical Biochemistry, 2004, 329 (2), pp.253-62. ⟨10.1016/j.ab.2004.02.013⟩ Article dans une revue hal-00318979v1
Locking the dimeric GABA(B) G-protein-coupled receptor in its active state. Julie Kniazeff,Pierre-Philippe Saintot,Cyril Goudet,Jianfeng Liu,Annie Charnetet al. Journal of Neuroscience, 2004, 24 (2), pp.370-7. ⟨10.1523/JNEUROSCI.3141-03.2004⟩ Article dans une revue hal-00319013v1
Divergent Evolution in Metabotropic Glutamate Receptors Christian Mitri,Marie-Laure Parmentier,Jean-Philippe Pin,Joël Bockaert,Yves Grau Journal of Biological Chemistry, 2004, 279 (10), pp.9313-9320. ⟨10.1074/jbc.M310878200⟩ Article dans une revue hal-02506712v1
Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors. Cyril Goudet,Florence Gaven,Julie Kniazeff,Claire Vol,Jianfeng Liuet al. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (1), pp.378-83. ⟨10.1073/pnas.0304699101⟩ Article dans une revue inserm-00319003v1
Closed state of both binding domains of homodimeric mGlu receptors is required for full activity. Julie Kniazeff,Anne-Sophie Bessis,Damien Maurel,Hervé Ansanay,Laurent Prézeauet al. Nature Structural and Molecular Biology, 2004, 11 (8), pp.706-13. ⟨10.1038/nsmb794⟩ Article dans une revue hal-00318999v1
The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor. Virginie Binet,Carole Brajon,Laurent Le Corre,Francine Acher,Jean-Philippe Pinet al. Journal of Biological Chemistry, 2004, 279 (28), pp.29085-91. ⟨10.1074/jbc.M400930200⟩ Article dans une revue inserm-00318926v1
Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit. Jianfeng Liu,Damien Maurel,Sébastien Etzol,Isabelle Brabet,Hervé Ansanayet al. Journal of Biological Chemistry, 2004, 279 (16), pp.15824-30. ⟨10.1074/jbc.M313639200⟩ Article dans une revue hal-00319008v1
A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor. Béatrice Duthey,Sara Caudron,Julie Perroy,Bernhard Bettler,Laurent Fagniet al. Journal of Biological Chemistry, 2002, 277 (5), pp.3236-41. ⟨10.1074/jbc.M108900200⟩ Article dans une revue inserm-00318936v1
A single olfactory receptor specifically binds a set of odorant molecules Isabelle Gaillard,Sylvie Rouquier,Jean-Philippe Pin,Patrice Mollard,Sylvain Richardet al. European Journal of Neuroscience, 2002, 15 (3), pp.409-418. ⟨10.1046/j.0953-816x.2001.01871.x⟩ Article dans une revue istex hal-02948481v1
Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons Fabrice Ango,David Robbe,J.C. Tu,B. Xiao,P.F. Worleyet al. Molecular and Cellular Neuroscience, 2002, 20, pp.323-329. ⟨10.1006/mcne.2002.1100⟩ Article dans une revue istex hal-00016884v1
BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Fiona Y. Carroll,Andreas Stolle,Philip M. Beart,Arnd Voerste,Isabelle Brabetet al. Molecular Pharmacology, 2001, 59 (5), pp.965-73. ⟨10.1124/mol.59.5.965⟩ Article dans une revue inserm-00319007v1
The C terminus of the metabotropic glutamate receptor subtypes 2 and 7 specifies the receptor signaling pathways Julie Perroy,G. J. Gutierrez,V. Coulon,Joël Bockaert,Jean-Philippe Pinet al. Journal of Biological Chemistry, 2001, 276 (49), pp.45800--45805. ⟨10.1074/jbc.M106876200⟩ Article dans une revue hal-02197463v1
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Conformational analysis of glutamic acid analogues as probes of glutamate receptors using molecular modelling and NMR methods. Comparison with specific agonists Nathalie Todeschi,Josyane Gharbi-Benarous,Francine Acher,Valery Laure,Jean-Philippe Pinet al. Bioorganic and Medicinal Chemistry Letters, 1997, 5 (2), pp.335-352. ⟨10.1016/s0968-0896(96)00252-0⟩ Article dans une revue istex hal-02356241v1
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Time-resolved FRET based assays to characterize hetero-oligomer pharmacology Joyce Heuninck,Candide Hounsou,Elodie Dupuis,Eric Trinquet,Bernard Mouillacet al. Mario Tiberi. G Protein-Coupled Receptor Signaling: Methods and Protocols, 1947, Springer New York, pp.151-168, 2019, Methods in Molecular Biology, 978-1-4939-9120-4. ⟨10.1007/978-1-4939-9121-1_8⟩ Chapitre d'ouvrage hal-03563498v1
Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding Orestis Faklaris,Joyce Heuninck,Amandine Falco,Elise Goyet,Jurriaan M. Zwieret al. Structure and Function of GPCRs, pp.217-252, 2017, ⟨10.1007/7355_2017_2⟩ Chapitre d'ouvrage hal-02391215v1
Time-Resolved FRET Strategy to Screen GPCR Ligand Library Nadia Oueslati,Candide Hounsou,Abderazak Belhocine,Thieric Rodriguez,Elodie Dupuiset al. Methods in Molecular Biology, 1272, pp.23-36, 2015, ⟨10.1007/978-1-4939-2336-6_2⟩ Chapitre d'ouvrage hal-02068533v1
Time-Resolved Förster Resonance Energy Transfer-Based Technologies to Investigate G Protein-Coupled Receptor Machinery Pauline Scholler,Jurriaan Zwier,Eric Trinquet,Philippe Rondard,Jean-Philippe Pinet al. Fluorescence-Based Biosensors - From Concepts to Applications, 113, Elsevier, pp.275-312, 2013, Progress in Molecular Biology and Translational Science, ⟨10.1016/B978-0-12-386932-6.00007-7⟩ Chapitre d'ouvrage hal-03363917v1

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