Jenny VALLADEAU-GUILEMOND

Publications

Article dans une revue (32)

IntegrAlign: a comprehensive tool for multi-immunofluorescence panel integration through image alignment Leo Hermet,Leo Laoubi,Martial Scavino,Anne-Claire Doffin,Alexia Gazeuet al. Bioinformatics, 2025, 41 (11), pp.btaf567. ⟨10.1093/bioinformatics/btaf567⟩ Article dans une revue hal-05345710v1
HERV-derived epitopes represent new targets for T-cell-based immunotherapies in ovarian cancer Paola Bonaventura,Audrey Page,Olivier Tabone,Yann Estornes,Virginie Mutezet al. Journal for Immunotherapy of Cancer, 2025, 13 (8), pp.e010099. ⟨10.1136/jitc-2024-010099⟩ Article dans une revue hal-05288554v1
The spatial organization of cDC1 with CD8+ T cells is critical for the response to immune checkpoint inhibitors in melanoma patients Elisa Gobbini,Margaux Hubert,Anne-Claire Doffin,Anais Eberhardt,Léo Hermetet al. Cancer Immunology Research, 2025, ⟨10.1158/2326-6066.CIR-24-0421⟩ Article dans une revue hal-04879746v1
Dendritic cells: the central partner for cancer immunity Léo Laoubi,Elisa Gobbini,Pierre Duplouye,Margaux Hubert,Christophe Cauxet al. OncoImmunology, 2025, 14 (1), pp.2571773. ⟨10.1080/2162402x.2025.2571773⟩ Article dans une revue (article de synthèse) hal-05472219v1
Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2 Candice Sakref,Alexis Saby,Céline Rodriguez,Maude Ardin,Lyvia Moudombiet al. Nature Communications, 2025, 16 (1), pp.3045. ⟨10.1038/s41467-025-58220-8⟩ Article dans une revue hal-05021654v1
Development of NK cell-based cancer immunotherapies through receptor engineering Audrey Page,Nicolas Chuvin,Jenny Valladeau-Guilemond,Stéphane Depil Cellular and molecular immunology, 2024, 21, pp.315 - 331. ⟨10.1038/s41423-024-01145-x⟩ Article dans une revue (article de synthèse) hal-04567993v1
Phenotypes and Functions of Human Dendritic Cell Subsets in the Tumor Microenvironment Candice Sakref,Nathalie Bendriss-Vermare,Jenny Valladeau-Guilemond Methods in Molecular Biology, 2023, Methods in Molecular Biology, 2618, pp.17-35. ⟨10.1007/978-1-0716-2938-3_2⟩ Article dans une revue hal-04480198v1
Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods Felix Bayerl,David A Bejarano,Giulia Bertacchi,Anne‐claire Doffin,Elisa Gobbiniet al. European Journal of Immunology, 2023, 53 (11), pp.2249923. ⟨10.1002/eji.202249923⟩ Article dans une revue hal-04477856v1
Isolation and Identification of Dendritic Cell Subsets from Human and Mouse Tumors Yamila Rocca,Aurélien Voissière,Jenny Valladeau-Guilemond,Nathalie Bendriss-Vermare Methods in Molecular Biology, 2023, Methods in Molecular Biology, 2618, pp.187-197. ⟨10.1007/978-1-0716-2938-3_14⟩ Article dans une revue hal-04480202v1
Unique CLR expression patterns on circulating and tumor-infiltrating DC subsets correlated with clinical outcome in melanoma patients Eleonora Sosa Cuevas,Jenny Valladeau-Guilemond,Stephane Mouret,Benoît Roubinet,Florence de Fraipontet al. Frontiers in Immunology, 2022, 13, pp.1040600. ⟨10.3389/fimmu.2022.1040600⟩ Article dans une revue hal-04098615v1
Direct T-cell Presentation by cDC1: The Key Feature for Cancer Vaccine Success? Margaux Hubert,Christophe Caux,Jenny Valladeau-Guilemond Cancer Immunology Research, 2022, 10 (8), pp.918-918. ⟨10.1158/2326-6066.CIR-22-0473⟩ Article dans une revue hal-03783998v1
Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy Paola Bonaventura,Vincent Alcazer,Virginie Mutez,Laurie Tonon,Juliette Martinet al. Science Advances , 2022, 8 (4), ⟨10.1126/sciadv.abj3671⟩ Article dans une revue hal-03552937v1
Diversification of circulating and tumor‐infiltrating plasmacytoid DCs towards the P3 (CD80 + PDL1 − )‐pDC subset negatively correlated with clinical outcomes in melanoma patients Eleonora Sosa Cuevas,Nathalie Bendriss-Vermare,Stephane Mouret,Florence de Fraipont,Julie Charleset al. Clinical and Translational Immunology, 2022, 11 (5), pp.e1382. ⟨10.1002/cti2.1382⟩ Article dans une revue hal-03783977v1
Type 1 conventional dendritic cells and interferons are required for spontaneous CD4 + and CD8 + T‐cell protective responses to breast cancer Raphaël Mattiuz,Carine Brousse,Marc Ambrosini,Jean‐charles Cancel,Gilles Bessouet al. Clinical and Translational Immunology, 2021, 10, ⟨10.1002/cti2.1305⟩ Article dans une revue hal-03329001v1
IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer Margaux Hubert,Elisa Gobbini,Coline Couillault,Thien-Phong Vu Manh,Anne-Claire Doffinet al. Science Immunology, 2020, 5 (46), pp.eaav3942. ⟨10.1126/sciimmunol.aav3942⟩ Article dans une revue hal-02998632v1
Hepatitis B virus exploits C‐type lectin receptors to hijack cDC1s, cDC2s and pDCs Laurissa Ouaguia,Tania Dufeu-Duchesne,Vincent Leroy,Thomas Decaens,Jean-Baptiste Reiseret al. Clinical and Translational Immunology, 2020, 9 (12), pp.e1208. ⟨10.1002/cti2.1208⟩ Article dans une revue hal-03183870v1
BDCA1 + cDC2s, BDCA2 + pDCs and BDCA3 + cDC1s reveal distinct pathophysiologic features and impact on clinical outcomes in melanoma patients Eleonora Sosa Cuevas,Laurissa Ouaguia,Stephane Mouret,Julie Charles,Florence Fraipontet al. Clinical and Translational Immunology, 2020, 9 (11), pp.e1190. ⟨10.1002/cti2.1190⟩ Article dans une revue hal-03329086v1
Expression of TAM-R in Human Immune Cells and Unique Regulatory Function of MerTK in IL-10 Production by Tolerogenic DC Paul Giroud,Sarah Renaudineau,Laura Gudefin,Alexandre Calcei,Thierry Menguyet al. Frontiers in Immunology, 2020, 11, ⟨10.3389/fimmu.2020.564133⟩ Article dans une revue hal-03769650v1
Circulating and Hepatic BDCA1+, BDCA2+, and BDCA3+ Dendritic Cells Are Differentially Subverted in Patients With Chronic HBV Infection Laurissa Ouaguia,Vincent Leroy,Tania Dufeu-Duchesne,David Durantel,Thomas Decaenset al. Frontiers in Immunology, 2019, 10, pp.112. ⟨10.3389/fimmu.2019.00112⟩ Article dans une revue hal-02361633v1
Cold Tumors: A Therapeutic Challenge for Immunotherapy Paola Bonaventura,Tala Shekarian,Vincent Alcazer,Jenny Valladeau-Guilemond,Sandrine Valsesia-Wittmannet al. Frontiers in Immunology, 2019, 10, pp.168. ⟨10.3389/fimmu.2019.00168⟩ Article dans une revue (article de synthèse) hal-03769056v1
Human Tumor-Infiltrating Dendritic Cells: From in Situ Visualization to High-Dimensional Analyses Margaux Hubert,Elisa Gobbini,Nathalie Bendriss-Vermare,Christophe Caux,Jenny Valladeau-Guilemond Cancers, 2019, 11 (8), pp.1082. ⟨10.3390/cancers11081082⟩ Article dans une revue hal-03769128v1
Immune cell dysfunctions in breast cancer patients detected through whole blood multi-parametric flow cytometry assay E. Verronèse,A. Delgado,Jenny Valladeau-Guilemond,G. Garin,S. Guillemautet al. OncoImmunology, 2016, 5 (3), pp.e1100791. ⟨10.1080/2162402X.2015.1100791⟩ Article dans une revue hal-01796186v1
Human natural killer cells promote cross-presentation of tumor cell-derived antigens by dendritic cells Florence Deauvieau,Vincent Ollion,Anne-Claire Doffin,Carole Achard,Jean-François Fonteneauet al. International Journal of Cancer, 2015, 136 (5), pp.1085-1094. ⟨10.1002/ijc.29087⟩ Article dans une revue inserm-02913986v1
A novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage Colette Dezutter-Dambuyant,Isabelle Durand,Laurent Alberti,Nathalie Bendriss-Vermare,Jenny Valladeau-Guilemondet al. OncoImmunology, 2015, 5, ⟨10.1080/2162402x.2015.1091146⟩ Article dans une revue hal-03045642v1
Alteration of the langerin oligomerization state affects Birbeck granule formation Eric Chabrol,Michel Thépaut,Colette Dezutter-Dambuyant,Corinne Vivès,Julien Marcouxet al. Biophysical Journal, 2015, 108 (3), pp.666-77. ⟨10.1016/j.bpj.2014.10.075⟩ Article dans une revue hal-01150862v1
Characterization of resident and migratory dendritic cells in human lymph nodes. Elodie Segura,Jenny Valladeau-Guilemond,Marie-Hélène Donnadieu,Xavier Sastre-Garau,Vassili Soumeliset al. Journal of Experimental Medicine, 2012, 209 (4), pp.653-60. ⟨10.1084/jem.20111457⟩ Article dans une revue hal-00723792v1
HIV-1 clade promoters strongly influence spatial and temporal dynamics of viral replication in vivo. Mireille Centlivre,Peter Sommer,Marie Michel,Raphaël Ho Tsong Fang,Sandrine Goffloet al. Journal of Clinical Investigation, 2010, 115 (2), pp.348-58. ⟨10.1172/JCI200522873⟩ Article dans une revue pasteur-00013742v1
Poly(I:C)-Treated human langerhans cells promote the differentiation of CD4+ T cells producing IFN-gamma and IL-10. Laetitia Furio,Hermine Billard,Jenny Valladeau,Josette Péguet-Navarro,Odile Berthier-Vergnes Journal of Investigative Dermatology, 2009, 129 (8), pp.1963-71. ⟨10.1038/jid.2009.21⟩ Article dans une revue hal-00425195v1
Structural studies of langerin and birbeck granule: a macromolecular organization model M. Thepaut,J. Valladeau,A. Nurisso,R. Kahn,B. Arnouet al. Biochemistry, 2009, pp.2684-2698 Article dans une revue hal-00373987v1
Human Langerhans cells express a specific TLR profile and differentially respond to viruses and Gram-positive bacteria. Vincent Flacher,Marielle Bouschbacher,Estelle Verronèse,Catherine Massacrier,Vanja Sisiraket al. Journal of Immunology, 2006, 177 (11), pp.7959-67 Article dans une revue hal-00180965v1
The HIV-1 clade C promoter is particularly well adapted to replication in the gut in primary infection. Mireille Centlivre,Peter Sommer,Marie Michel,Raphaël Ho Tsong Fang,Sandrine Goffloet al. AIDS. Official journal of the international AIDS Society, 2006, 20 (5), pp.657-66. ⟨10.1097/01.aids.0000216365.38572.2f⟩ Article dans une revue pasteur-00850258v1
Human Langerhans Cells Express a Specific TLR Profile and Differentially Respond to Viruses and Gram-Positive Bacteria Vincent Flacher,Marielle Bouschbacher,Estelle Verronèse,Catherine Massacrier,Vanja Sisiraket al. Journal of Immunology, 2006, 177 (11), pp.7959-7967. ⟨10.4049/jimmunol.177.11.7959⟩ Article dans une revue hal-03908429v1

Pré-publication, Document de travail (3)

Refined cellular activity expression signatures provide a targeted framework to quantify phenotypic intra-tumor heterogeneity in single-cell data Angèle Coutant,Lauriane Muller,Cyril Dégletagne,Frédérique Fauvet,Islam El Boudiet al. 2026 Pré-publication, Document de travail hal-05528591v1
CD4 T cells and neutrophils contribute to epithelial-mesenchymal transition in breast cancer Amélien Sanlaville,Aurélien Voissiere,Dominique Poujol,Margaux Hubert,Suzanne Andréet al. 2025 Pré-publication, Document de travail hal-04862552v1
IL-33 drives polyfunctionality and antitumor activity of a unique ST2+ NK cell population Anaïs Eberhardt,Elena Blanc,Valentin Picant,Vincent Alcazer,Yamila Roccaet al. 2022 Pré-publication, Document de travail (preprint/prepublication) hal-03877982v1

Communication dans un congrès (7)

IFN-III primes pDCs for TLR7 activation and antagonizes TGF-β and PGE2 mediated-immune suppression Alexis Saby,Candice Sakref,Céline Rodriguez,Lyvia Moudombi,Aurelien Voissiereet al. 17th International Symposium on Dendritic Cells, Oct 2024, Barcelona (ES), Spain Communication dans un congrès hal-04944678v1
Identification and function of the dendritic cell landscape in human tumors Jenny Valladeau-Guilemond 11èmes Journée d’Immunologie et Immunothérapie des Cancers (JIIC), Dec 2024, Dijon, France Communication dans un congrès hal-04967362v1
Characterization of the dendritic cell landscape in human tumors Jenny Valladeau-Guilemond Montpellier Infection & Immunology Meeting, Nov 2024, Montpellier, France Communication dans un congrès hal-04967343v1
Spatial organization and prognostic impact of dendritic cell subsets in a large cohort of triple negative breast cancer patients Elisa Gobbini,Margaux Hubert,Anne-Claire Doffin,Candice Sakref,Justine Berthetet al. Club Francophone des Cellules Dendritiques, Dec 2021, Paris, France Communication dans un congrès hal-04944901v1
BDCA3hi dendritic cells infiltrate breast and ovarian tumors but are functionally altered Margaux Hubert,Vincent Ollion,Anne-Claire Doffin,Estelle Verronese,Isabelle Durandet al. 14th International Conference on Innate Immunity, Jun 2017, Heraklion, Greece Communication dans un congrès hal-04967697v1
BDCA3hi dendritic cells infiltrate breast and ovarian tumors but are functionally altered Margaux Hubert,Vincent Ollion,Anne-Claire Doffin,Estelle Verronese,Isabelle Durandet al. IRCI Symposium 2017, Feb 2017, Lyon, France Communication dans un congrès hal-04967713v1
BDCA3hi dendritic cells infiltrate human primary breast tumors and correlate with a good prognosis Margaux Hubert,Hélène Lopez-Maestre,Coline Couillault,Vincent Ollion,Christophe Sajouset al. Joint annual meetings of the SFI and AFC, Nov 2017, Reims, France Communication dans un congrès hal-04967734v1

Poster de conférence (2)

Identification of the dendritic cell landscape in human tumors by multi-immunofluorescence and scRNAseq Margaux Hubert,Elisa Gobbini,Anne-Claire Doffin,Sarah Bardin,Justine Berthetet al. 16th International Symposium on Dendritic Cells 2022, Oct 2022, Cairns (Australie), Australia Poster de conférence hal-04967664v1
Type III Interferons primes pDC for TLR7 activation and unleash pDC function in tumors Candice Sakref,Alexis Saby,Margaux Hubert,Anne-Claire Doffin,Léo Laoubiet al. Joint annual meetings of the SFI and AFC, Nov 2022, Nice, France Poster de conférence hal-04967679v1

Brevet (6)

Type iii interferon for use as a biomarker to predict response to a cancer treatment Christophe Caux,Jenny Valladeau-Guilemond,Margaux Hubert France, Patent n° : EP3892739A1. 2021 Brevet hal-04715664v1
TYPE III INTERFERON FOR USE AS A BIOMARKER TO PREDICT RESPONSE TO A CANCER TREATMENT Christophe Caux,Jenny Valladeau-Guilemond,Margaux Hubert France, Patent n° : WO2021205024. 2021 Brevet hal-04940563v1
Interféron de type iii destiné à être utilisé en tant que biomarqueur pour prédire une réponse à un traitement anticancéreux Jenny Valladeau-Guilemond France, Patent n° : WO2021205024A1. 2021 Brevet hal-04963947v1
Antigènes dérivés d'herv-k en tant qu'antigènes tumoraux partagés pour un vaccin anticancéreux Stéphane Depil,Laurie Tonon,Christophe Caux,Paola Bonaventura,Jenny Valladeau-Guilemond France, Patent n° : WO2020049169A1. 2020 Brevet hal-04940961v1
Gènes de protéine de membrane cellulaire dendritique isolée Jenny Valladeau-Guilemond France, Patent n° : EP1980573A2. 2008 Brevet hal-04964089v1
Anticorps lies a un antigene mammalien de la cellule de langerhans et leurs utilisations Jenny Valladeau-Guilemond France, Patent n° : WO2000018803A2. 2000 Brevet hal-04964083v1