Jérémy Denizot

Publications

Article dans une revue (24)

Adherent-invasive E. coli (AIEC) in Crohn’s disease: where are we in 2025? Tribute to Professor Nicolas Barnich Anthony Buisson,Jérémy Denizot Clinics and Research in Hepatology and Gastroenterology, 2025, 49 (10), pp.102727. ⟨10.1016/j.clinre.2025.102727⟩ Article dans une revue hal-05543843v1
Adherent-invasive Escherichia coli in Crohn’s disease: the 25th anniversary Nicolas Barnich,Janelle C Arthur,Anthony Buisson,Barry J Campbell,Franck Carbonnelet al. Gut, In press, pp.gutjnl-2025-335331. ⟨10.1136/gutjnl-2025-335331⟩ Article dans une revue pasteur-05265332v1
Development of a combination of probiotics and plant extracts targeting adherent-invasive Escherichia coli associated with Crohn’s disease F. de Clercq,N. Boisseau,C. Leclaire,J. Denizot,S. Holowaczet al. Beneficial Microbes, 2025, pp.1-17. ⟨10.1163/18762891-bja00095⟩ Article dans une revue hal-05319060v1
ChiA: a major player in the virulence of Crohn’s disease-associated adherent and invasive Escherichia coli (AIEC) Margot Fargeas,Frederic Faure,Clara Douadi,Caroline Chevarin,Aurélien Bireret al. Gut microbes, 2024, 16 (1), ⟨10.1080/19490976.2024.2412667⟩ Article dans une revue (data paper) hal-04809777v1
An adherent-invasive Escherichia coli -colonized mouse model to evaluate microbiota-targeting strategies in Crohn's disease Adeline Sivignon,Mélissa Chervy,Caroline Chevarin,Elia Ragot,Elisabeth Billardet al. Disease Models & Mechanisms, 2022, 15 (10), pp.dmm049707. ⟨10.1242/dmm.049707⟩ Article dans une revue hal-03907399v1
Epigenetic master regulators HDAC1 and HDAC5 control pathobiont Enterobacteria colonization in ileal mucosa of Crohn’s disease patients Mélissa Chervy,Adeline Sivignon,Flavie Dambrine,Anthony Buisson,Pierre Sauvanetet al. Gut microbes, 2022, 14 (1), pp.1-13. ⟨10.1080/19490976.2022.2127444⟩ Article dans une revue hal-03881385v1
Propionate catabolism by CD-associated adherent-invasive E. coli counteracts its anti-inflammatory effect Allison Agus,Damien Richard,Tiphanie Faïs,Emilie Vazeille,Mélissa Chervyet al. Gut microbes, 2021, 13 (1), pp.1-19. ⟨10.1080/19490976.2020.1839318⟩ Article dans une revue hal-03262359v1
Adaptation of adherent-invasive E. coli to gut environment: Impact on flagellum expression and bacterial colonization ability Gwladys Sevrin,Sébastien Massier,Benoit Chassaing,Allison Agus,Julien Delmaset al. Gut microbes, 2020, 11 (3), pp.364-380. ⟨10.1080/19490976.2017.1421886⟩ Article dans une revue hal-01730371v1
Adherent-Invasive E. coli: Update on the Lifestyle of a Troublemaker in Crohn's Disease Mélissa Chervy,Nicolas Barnich,Jérémy Denizot International Journal of Molecular Sciences, 2020, 21 (10), pp.3734. ⟨10.3390/ijms21103734⟩ Article dans une revue (article de synthèse) hal-02917127v1
Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium Juri Kazakevych,Jérémy Denizot,Anke Liebert,Mariana Portovedo,Mia Mosavieet al. Genome Biology, 2020, 21 (1), pp.1-20. ⟨10.1186/s13059-020-01976-7⟩ Article dans une revue hal-02541660v1
Methyl-donor supplementation prevents intestinal colonization by Adherent-invasive E. coli in a mouse model of crohn's disease Elodie Gimier,Mélissa Chervy,Allison Agus,Adeline Sivignon,Elisabeth Billardet al. Scientific Reports, 2020, 10, pp.12922. ⟨10.1038/s41598-020-69472-3⟩ Article dans une revue hal-02917129v1
When adherent-invasive E. coli plays with host glycosylation: Does it open new perspectives for therapeutic strategies in Crohn's disease? Jérémy Denizot,Nicolas Barnich EBioMedicine, 2020, 55, pp.1-2. ⟨10.1016/j.ebiom.2020.102752⟩ Article dans une revue hal-02912994v1
Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells Hashem Koohy,Daniel Bolland,Louise Matheson,Stefan Schoenfelder,Claudia Stellatoet al. Genome Biology, 2018, 19 (1), ⟨10.1186/s13059-018-1489-y⟩ Article dans une revue hal-01929162v1
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases Rachel Fellows,Jérémy Denizot,Claudia Stellato,Alessandro Cuomo,Payal Jainet al. Nature Communications, 2018, 9 (1), pp.1-15. ⟨10.1038/s41467-017-02651-5⟩ Article dans une revue hal-01759208v1
Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation. Allison Agus,Jérémy Denizot,Jonathan Thevenot,Margarita Martinez-Medina,Sébastien Massieret al. Scientific Reports, 2016, 6 (1), pp.19032. ⟨10.1038/srep19032⟩ Article dans une revue hal-01928173v1
Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associated Escherichia coli colonisation Jérémy Denizot,Alexis Desrichard,Allison Agus,Nancy Uhrhammer,Nicolas Dreuxet al. Gut, 2015, 64 (3), pp.428-437. ⟨10.1136/gutjnl-2014-306944⟩ Article dans une revue hal-04616080v1
Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associated Escherichia coli colonisation Jérémy Denizot,Alexis Desrichard,Allison Agus,Nancy Uhrhammer,Nicolas Dreuxet al. Gut, 2015, 64 (3), pp.428 - 437. ⟨10.1136/gutjnl-2014-306944⟩ Article dans une revue hal-01928389v1
Saccharomyces cerevisiae CNCM I-3856 Prevents Colitis Induced by AIEC Bacteria in the Transgenic Mouse Model Mimicking Crohnʼs Disease Adeline Sivignon,Amélie de Vallée,Nicolas Barnich,Jérémy Denizot,Claude Darchaet al. Inflammatory Bowel Diseases, 2015, 21 (2), pp.276 - 286. ⟨10.1097/MIB.0000000000000280⟩ Article dans une revue hal-01928174v1
Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response Nicolas Dreux,Jérémy Denizot,Margarita Martinez-Medina,Alexander Mellmann,Maria Billiget al. PLoS Pathogens, 2013, 9 (1), pp.e1003141. ⟨10.1371/journal.ppat.1003141⟩ Article dans une revue hal-01928191v1
E. coli-mediated gut inflammation in genetically predisposed Crohn's disease patients N. Barnich,Jérémy Denizot,A. Darfeuille-Michaud Pathologie Biologie, 2013, 61 (5), pp.e65 - e69. ⟨10.1016/j.patbio.2010.01.004⟩ Article dans une revue hal-01928194v1
Western diet induces dysbiosis with increased E coli in CEABAC10 mice , alters host barrier function favouring AIEC colonisation Margarita Martinez-Medina,Jérémy Denizot,Nicolas Dreux,Frédéric Robin,Elisabeth Billardet al. Gut, 2013, 63 (1), pp.116 - 124. ⟨10.1136/gutjnl-2012-304119⟩ Article dans une revue hal-01928324v1
Importance of Bacteria as Trigger in Inflammatory Bowel Disease Jérémy Denizot,Nicolas Dreux,Arlette Darfeuille-Michaud,Nicolas Barnich Journal of Gastrointestinal & Digestive System, 2012, 01, pp.S8. ⟨10.4172/2161-069x.s8-003⟩ Article dans une revue hal-01928200v1
Adherent-Invasive Escherichia coli Induce Claudin-2 Expression and Barrier Defect in CEABAC10 Mice and Crohnʼs Disease Patients Jérémy Denizot,Adeline Sivignon,Frederick Barreau,Claude Darcha,Carlos H.F. Chanet al. Inflammatory Bowel Diseases, 2012, 18 (2), pp.294 - 304. ⟨10.1002/ibd.21787⟩ Article dans une revue hal-01928192v1
Interactions with M cells and macrophages as key steps in the pathogenesis of enterohemorrhagic Escherichia coli infections L Etienne-Mesmin,B Chassaing,P Sauvanet,J Denizot,S Blanquet-Diotet al. PLoS ONE, 2011, 6 (8), pp.e23594. ⟨10.1371/journal.pone.0023594⟩ Article dans une revue hal-00748909v1

Communication dans un congrès (15)

Host cell alterations and pathogen multiplication in an in vitro epithelial intestinal model of co-infection with the microsporidium Encephalitozoon intestinalis and the enterovirus A71 Bélélé Siméon Bakyono,Jean-Luc Bailly,Maxime Bisseux,Jérémy Denizot,Catherine Texier 8eme journée des microscopistes clermontois, Plateforme Clermont Imagerie Confocale, Nov 2025, Clermont-Ferrand, France Communication dans un congrès hal-05365163v1
ChiA, a major player in the pathogenicity of adherent and invasive E. coli bacteria (AIEC) associated with Crohn's disease. Margot Fargeas,Frédéric Faure,Clara Douadi,Caroline Chevarin,Adeline Sivignonet al. Journées scientifiques de l'école doctorale SVSAE (Sciences de la Vie, de la Santé, de l'Agronomie et de l'Environnement), Jun 2024, Clermont-Ferrand, France Communication dans un congrès hal-04974353v1
Presentation of endochitinase ChiA, a virulence factor involved in the pathogenecity of adherent and invasive Escherichia coli associated with Crohn’s Disease Margot Fargeas,Frédéric Faure,Clara Douadi,Caroline Chevarin,Adeline Sivignonet al. G-REEMI, Oct 2024, Clermont-Ferrand, France Communication dans un congrès hal-04974385v1
Élaboration d'une formulation combinant souches bactériennes et extraits végétaux ciblant les souches « Adherent Invasive Escherichia coli » (AIEC) associées à la maladie de Crohn Fanny de Clercq,Charlotte Leclaire,Jérémy Denizot,Sophie Holowacz,Nathalie Boisseauet al. Journée Nutrition & Microbiote (De la prévention à la thérapie), Atlanpole Biothérapies, Nov 2024, Nantes, France Communication dans un congrès hal-04959285v1
ChiA, un acteur majeur impliqué dans le pouvoir pathogène des bactéries E. coli adhérentes et invasives (AIEC) associées à la maladie de Crohn. Margot Fargeas,Frédéric Faure,Clara Douadi,Jérémy Denizot,Elisabeth Billardet al. Journée des microbiologistes de Clermont-Ferrand, Apr 2024, Clermont-Ferrand, France Communication dans un congrès hal-04974290v1
Contribution of HIF2-a in iron bioavailability against adherent invasive Escherichia Coli infection. Marion Falabrègue,Candice Aurrand,Benoit Chassaing,Nicolas Barnich,Jérémy Denizotet al. European Iron Club Congress 2024, Apr 2024, Toulouse, France Communication dans un congrès hal-05302203v1
Epigenetic eraser histone deacetylase 1 (HDAC1) limits AIEC-induced inflammatory response in intestinal epithelial cells Jérémy Denizot,Mélissa Chervy,Flavie Dambrine,Lionel Le Bourhis,Matthieu Allezet al. 25th anniversary of AIEC discovery, Nov 2023, New york, United States Communication dans un congrès hal-04841555v1
“pVill-hCC6”: A NEW MOUSE MODEL MIMICKING ILEAL COLONIZATION BY AIEC BACTERIA TO EVALUATE MICROBIOTA-TARGETING STRATEGIES IN CROHN’S DISEASE Adeline Sivignon,Mélissa Chervy,Caroline Chevarin,Elisabeth Billard,Jérémy Denizotet al. Digestive Disease Week 2022, DDW, May 2022, San diego (Californie), United States Communication dans un congrès hal-04959953v1
Role of HDAC in the mechanism of infection of intestinal epithelial cells by adherent-invasive Escherichia coli bacteria isolated from patients with Crohn’s disease Mélissa Chervy,Nicolas Barnich,Jérémy Denizot Journées de l'Ecole doctorale SVSAE 2021, Jun 2021, Clermont-ferrand, France Communication dans un congrès hal-04977418v1
Development of solution based on natural polymers in order to reduce the therapeutic doses of current treatments and their adverse effects in chronic Inflammatory Bowel Diseases (IBD) Améline Delanne,Jérémy Denizot,Ghislain Garrait,Khaled Fadhlaoui,Arthur Chervetet al. Journée de l'Ecole Doctorale ED-SVSAE, May 2021, Clermont-Ferrand (FR), France Communication dans un congrès hal-04841306v1
Identification of EMP2 gene as a new therapeutic target to limit AIEC colonization in CD patients Mélissa Chervy,Nicolas Barnich,Jérémy Denizot UEGW 2020, Oct 2020, AMSTERDAM, France Communication dans un congrès hal-03046335v1
Un régime enrichi en molécules donneuses de groupements méthyles limite la colonisation intestinale par les E. coli adhérents et invasifs associées à la maladie de Crohn Elodie Gimier,Nicolas Barnich,Jérémy Denizot 4ème Assises Régionales de Nutrition et Santé, Sep 2019, LYON, France Communication dans un congrès hal-02393210v1
Un régime enrichi en molécules donneuses de groupements méthyles limite la colonisation intestinale par les E. coli adhérents et invasifs associées à la maladie de Crohn Elodie Gimier,Nicolas Barnich,Jérémy Denizot 4èmes Assises Régionales de Nutrition et Santé, Sep 2019, Lyon (France), France Communication dans un congrès hal-04977307v1
Impact of western diet on short-chain fatty acids production and host susceptibility to intestinal inflammation in a context of Crohn's disease Allison Agus,Jérémy Denizot,Jonathan Thevenot,Sébastien Massier,Sylvain Deniset al. 10. Congress of the European Crohn's and Colitis Organisation (ECCO) Inflamatory Bowel Diseases, European Crohn´s and Colitis Organisation (ECCO). INT., Feb 2015, Barcelona, Spain Communication dans un congrès hal-02740401v1
Involvement of type VI secretion systems in virulence of adherent-invasive &lt;em&gt;Escherichia coli&lt;/em&gt; isolated from patients with Crohn's disease Sébastien Massier,Sylvie Miquel,Nicolas Dreux,Allison Agus,S. Bouhourset al. 10. Congress of ECCO. Inflammatory Bowel Diseases, ECCO European Crohn's and Colitis Organization., Feb 2015, Barcelona, Spain Communication dans un congrès hal-02739694v1

Poster de conférence (14)

Interaction between Chitinase 3-like 1 (CHI3L1) and bacterial protein ChiA : a decisive step for Crohn’s disease-associated adherent and invasive E. coli to enter within human macrophages. Margot Fargeas,Frédéric Faure,Caroline Chevarin,Clara Douadi,Adeline Sivignonet al. Digestive Disease Week (DDW), May 2024, Washington, United States Poster de conférence hal-04974337v1
Interaction between Chitinase 3-like 1 (CHI3L1) and bacterial protein ChiA : a decisive step for Crohn’s disease-associated adherent and invasive E. coli to enter within human macrophages. Margot Fargeas,Frédéric Faure,Clara Douadi,Adeline Sivignon,Caroline Chevarinet al. European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Apr 2024, Barcenola, Spain Poster de conférence hal-04974301v1
Development of a combination of probiotics and plant extracts targeting Adherent-Invasive Escherichia coli associated with Crohn's disease Fanny de Clercq,Charlotte Leclaire,Jérémy Denizot,Sophie Holowacz,Nathalie Boisseauet al. Final symposium of the Microbiota cross-cutting program of Inserm, Oct 2024, Paris necker, France Poster de conférence hal-04959963v1
AIEC LF82 cobB Deacetylase Targets the Intestinal Epithelial Cell Nucleus to Enhance Adhesion and Regulate Inflammation During Infection Flavie Dambrine,Florian Coudray,Perrine Bouvard,N. Barnich,Jérémy Denizot Programme Transverse Microbiote Inserm 2024, Oct 2024, Paris, France Poster de conférence hal-04977540v1
ChiA, a virulence factor playing a role in adherent and invasive E. coli (AIEC) pathogenicity Margot Fargeas,Frédéric Faure,Clara Douadi,Jérémy Denizot,Elisabeth Billardet al. AIEC congress, Nov 2023, New York (NY), United States Poster de conférence hal-04974276v1
A central contribution of HIF-2α in the nutritional immunity against AIEC Marion Falabrègue,Candice Aurrand,Benoît Chassaing,Jérémy Denizot,Nicolas Barnichet al. 25th Anniversary of AIEC discovery, Nov 2023, New-York, United States Poster de conférence hal-04977484v1
EPIGENETIC MASTER REGULATORS HDAC1 AND HDAC5 CONTROL PATHOBIONT ENTEROBACTERIA COLONIZATION IN ILEAL MUCOSA IN CROHN’S DISEASE PATIENTS Mélissa Chervy,Adeline Sivignon,Nicolas Barnich,Jérémy Denizot G-RREMI 2022, Sep 2022, Lyon, France Poster de conférence hal-04977447v1
EPIGENETIC MASTER REGULATORS HDAC1 AND HDAC5 CONTROL PATHOBIONT ENTEROBACTERIA COLONIZATION IN ILEAL MUCOSA IN CROHN'S DISEASE PATIENTS Mélissa Chervy,Adeline Sivignon,Matthieu Allez,Lionel Le Bourhis,Nicolas Barnichet al. Digestive Disease Week 2022, May 2022, San Diego (California), United States Poster de conférence hal-04977395v1
EPIGENETIC MASTER REGULATORS HDAC1 AND HDAC5 CONTROL PATHOBIONT ENTEROBACTERIA COLONIZATION IN ILEAL MUCOSA IN CROHN’S DISEASE PATIENTS Mélissa Chervy,Adeline Sivignon,Nicolas Barnich,Jérémy Denizot EMBO Workshow Pathogen Immunity and Signaling, Apr 2022, Saint-Malo (35400), France Poster de conférence hal-04977437v1
Nutritional approach to restore impaired intestinal barrier function and inflammatory after inflammation induction in cells and mice models Améline Delanne,Jérémy Denizot,Ghislain Garrait,Khaled Fadhlaoui,Eric Beyssacet al. 12. International Symposium on Gut Microbiology, Oct 2021, En ligne, France. 2021 Poster de conférence hal-03394890v1
Development of a vector based on natural excipient in order to reduce the therapeutic doses of current treatments and their adverse effects in chronic inflammatory bowel diseases (IBD). Améline Delanne,Jérémy Denizot,Ghislain Garrait,Khaled Fadhlaoui,Arthur Chevetet al. Young Researchers of Auvergne Rhône Alpes Region Congress, Jun 2021, Virtual conference, France Poster de conférence hal-03417146v1
Development of a synergistic vector based on natural polymers in order to reduce the therapeutic doses of current treatments and their adverse effects in chronic inflammatory diseases (IBD). Améline Delanne,Jérémy Denizot,Ghislain Garrait,Sandrine Chalancon,Filipe Carvalhoet al. AAPS PharmSci 360 - American Association of Pharmaceutical Scientists, Oct 2020, Virtual conference, United States Poster de conférence hal-04841211v1
High methyl diet impair E. coli overgrowth, limits AIEC colonization and inflammation by epigenentic regulation of genes expression Nicolas Barnich,Jérémy Denizot,Allison Agus DDW, May 2019, SAN DIEGO, United States Poster de conférence hal-02187861v1
HIGH METHYL DIET IMPAIRS E. COLI OVERGROWTH, LIMITS AIEC COLONIZATION AND INFLAMMATION BY EPIGENETIC REGULATION OF GENES EXPRESSION Elodie Gimier,Allison Agus,Nicolas Barnich,Jérémy Denizot Digestive Disease Week 2019, May 2019, San Diego, United States Poster de conférence hal-04977327v1

Thèse (1)

Perméabilité intestinale et régulation de l'expression du gène CEACAM6 : implication des bactéries Escherichia coli associées à la maladie de Crohn Jérémy Denizot Médecine humaine et pathologie. Université d'Auvergne - Clermont-Ferrand I, 2013. Français. ⟨NNT : 2013CLF1MM04⟩ Thèse tel-01165207v1

HDR (1)

Etude des marques épigénétiques pour l’identification de biomarqueurs prédictifs du portage des bactéries E. coli adhérentes et invasives et de nouvelles cibles thérapeutiques pour le traitement personnalisé des patients atteints de maladie de Crohn Jérémy Denizot Sciences du Vivant [q-bio]. université clermont auvergne, 2020 HDR tel-04841532v1