Jonathan CLARHAUT

Publications

Article dans une revue (52)

Prediction of higher ceftazidime–avibactam concentrations in the human renal interstitium compared with unbound plasma using a minimal physiologically based pharmacokinetic model developed in rats and pigs through microdialysis Maxime Vallée,Vincent Aranzana-Climent,Jérémy Moreau,Isabelle Lamarche,Théo Fontanieret al. Antimicrobial Agents and Chemotherapy, 2025, 69 (3), pp.e0151824. ⟨10.1128/aac.01518-24⟩ Article dans une revue hal-04950970v1
GJA1-20k, a Short Isoform of Connexin43, from Its Discovery to Its Potential Implication in Cancer Progression Sarah Fournier,Jonathan Clarhaut,Laurent Cronier,Arnaud Monvoisin Cells, 2025, 14 (3), pp.180. ⟨10.3390/cells14030180⟩ Article dans une revue hal-05153972v1
Optimizing antimicrobial susceptibility testing: cost and environmental benefits of MIC volume reduction Jonathan Clarhaut,Jeremy Moreau,Tom Collet,Emma Babiard,Vincent Aranzana-Climentet al. Antimicrobial Agents and Chemotherapy, 2025, 69 (12), pp.e0070425. ⟨10.1128/aac.00704-25⟩ Article dans une revue hal-05321893v1
An Enzyme‐Responsive Self‐Immolative Recognition Marker for Manipulating Cell–Cell Interactions Chad Plumet,Spyridon Katsakos,Mélissa Girard,Israa Al Jamal,Jonathan Clarhautet al. Advanced Science, In press, ⟨10.1002/advs.202402278⟩ Article dans une revue hal-04641807v1
Impact of mixed Staphylococcus aureus-Pseudomonas aeruginosa biofilm on susceptibility to antimicrobial treatments in a 3D in vitro model Guillermo Landa,Jonathan Clarhaut,Julien Buyck,Gracia Mendoza,Manuel Arrueboet al. Scientific Reports, 2024, 14 (1), pp.27877. ⟨10.1038/s41598-024-79573-y⟩ Article dans une revue hal-05144149v1
Pan-azole-resistant Meyerozyma guilliermondii clonal isolates harbouring a double F126L and L505F mutation in Erg11. Jérémy Moreau,Thierry Noël,Kévin Point,Frederic Tewes,Luc Derocheet al. Mycoses, 2024, 67 (3), pp.e13704. ⟨10.1111/myc.13704⟩ Article dans une revue hal-04715648v1
Induced-volatolomics for the design of tumour activated therapy Rémi Châtre,Estelle Blochouse,Rony Eid,Fabiola Djago,Justin Langeet al. Chemical Science, 2023, 14 (18), pp.4697-4703. ⟨10.1039/d2sc06797h⟩ Article dans une revue hal-04098727v1
Combination of Targeted Therapies for Colorectal Cancer Treatment Elodie Péraudeau,Brigitte Renoux,Sheik Emambux,Pauline Poinot,Rémi Châtreet al. Molecular Pharmaceutics, 2023, 20 (9), pp.4537-4545. ⟨10.1021/acs.molpharmaceut.3c00224⟩ Article dans une revue hal-05019569v1
A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients Alexia Chauzy,Salim Bouchène,Vincent Aranzana-Climent,Jonathan Clarhaut,Christophe Adieret al. Antibiotics, 2022, 11 (10), pp.1293. ⟨10.3390/antibiotics11101293⟩ Article dans une revue hal-03906712v1
A β-Cyclodextrin-Albumin Conjugate for Enhancing Therapeutic Efficacy of Cytotoxic Drugs Chad Plumet,Rémi Châtre,Fabiola Djago,Elodie Péraudeau,Quentin Blancart-Remauryet al. Bioconjugate Chemistry, 2022, 33 (6), pp.1138-1144. ⟨10.1021/acs.bioconjchem.2c00182⟩ Article dans une revue hal-03765739v1
Cell–cell interactions via non-covalent click chemistry Chad Plumet,Achmet Said Mohamed,Tanguy Vendeuvre,Brigitte Renoux,Jonathan Clarhautet al. Chemical Science, 2021, 12 (26), pp.9017-9021. ⟨10.1039/D1SC01637G⟩ Article dans une revue hal-03285569v1
Selective radical depolymerization of cellulose to glucose induced by high frequency ultrasound Somia Haouache,Ayman Karam,Tony Chave,Jonathan Clarhaut,Prince Nana Amaniamponget al. Chemical Science, 2020, 11 (10), pp.2664-2669. ⟨10.1039/D0SC00020E⟩ Article dans une revue hal-02921911v1
In vivo synthesis of triple-loaded albumin conjugate for efficient targeted cancer chemotherapy Rémi Châtre,Justin Lange,Elodie Péraudeau,Pauline Poinot,Stéphanie Lerondelet al. Journal of Controlled Release, 2020, 327, pp.19-25. ⟨10.1016/j.jconrel.2020.08.008⟩ Article dans une revue hal-03491375v1
Cx43 Present at the Leading Edge Membrane Governs Promigratory Effects of Osteoblast-Conditioned Medium on Human Prostate Cancer Cells in the Context of Bone Metastasis Jonathan Boucher,Annie-Claire Balandre,Marjolaine Debant,Justine Vix,Thomas Harnoiset al. Cancers, 2020, 12 (10), pp.3013. ⟨10.3390/cancers12103013⟩ Article dans une revue hal-03176921v1
Volatile Organic Compound Based Probe for Induced Volatolomics of Cancers Justin Lange,Balkis Eddhif,Mehrad Tarighi,Théa Garandeau,Elodie Péraudeauet al. Angewandte Chemie International Edition, 2019, 58 (49), pp.17563-17566. ⟨10.1002/anie.201906261⟩ Article dans une revue hal-04508274v1
Controlled Release of a Micelle Payload via Sequential Enzymatic and Bioorthogonal Reactions in Living Systems Karine Porte,Brigitte Renoux,Elodie Péraudeau,Jonathan A. Clarhaut,Balkis Eddhifet al. Angewandte Chemie International Edition, 2019, 58 (19), pp.6366-6370. ⟨10.1002/anie.201902137⟩ Article dans une revue hal-02115783v1
A β-glucuronidase-responsive albumin-binding prodrug programmed for the double release of monomethyl auristatin E Brigitte Renoux,Laure Fangous,Camille Hötten,Elodie Péraudeau,Balkis Eddhifet al. MedChemComm, 2018, 9 (12), pp.2068-2071. ⟨10.1039/C8MD00466H⟩ Article dans une revue hal-04508272v1
2-Acetamido-2-deoxy- l -iminosugar C -Alkyl and C -Aryl Glycosides: Synthesis and Glycosidase Inhibition Balkis Eddhif,Justin Lange,Nadia Guignard,Yann Batonneau,Jonathan A. Clarhautet al. European Journal of Organic Chemistry, 2018, 2018 (40), pp.5477-5488. ⟨10.1002/ejoc.201800678⟩ Article dans une revue hal-02172201v1
Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis Jonathan Boucher,Claire Simonneau,Golthlay Denet,Jonathan Clarhaut,Claire Balandreet al. International Journal of Molecular Sciences, 2018, 19 (6), pp.1558. ⟨10.3390/ijms19061558⟩ Article dans une revue hal-02129345v1
A β-glucuronidase-responsive albumin-binding prodrug for potential selective kinase inhibitor-based cancer chemotherapy Guillaume Compain,Nassima Oumata,Jonathan A. Clarhaut,Elodie Péraudeau,Brigitte Renouxet al. European Journal of Medicinal Chemistry, 2018, 158, pp.1-6. ⟨10.1016/j.ejmech.2018.08.100⟩ Article dans une revue hal-02169782v1
TCA precipitation and ethanol/HCl single-step purification evaluation: One-dimensional gel electrophoresis, bradford assays, spectrofluorometry and Raman spectroscopy data on HSA, Rnase, lysozyme - Mascots and Skyline data Balkis Eddhif,Nadia Guignard,Yann Batonneau,Jonathan A. Clarhaut,Sébastien Papotet al. Data in Brief, 2018, 17, pp.938-953. ⟨10.1016/j.dib.2018.01.095⟩ Article dans une revue hal-02169942v1
Study of a novel agent for TCA precipitated proteins washing - comprehensive insights into the role of ethanol/HCl on molten globule state by multi-spectroscopic analyses Claude Geffroy-Rodier,Balkis Eddhif,Justin Lange,Nadia Guignard,Yann Batonneauet al. Journal of Proteomics, 2018, 173, pp.77 - 88. ⟨10.1016/j.jprot.2017.11.016⟩ Article dans une revue istex insu-01823781v1
Enhancing tumor response to targeted chemotherapy through up-regulation of folate receptor α expression induced by dexamethasone and valproic acid E. Peraudeau,L. Cronier,A. Monvoisin,P. Poinot,C. Mergaultet al. Journal of Controlled Release, 2018, 269, pp.36-44. ⟨10.1016/j.jconrel.2017.11.011⟩ Article dans une revue hal-02122599v1
In situ targeted activation of an anticancer agent using ultrasound-triggered release of composite droplets Marine Bezagu,Jonathan A. Clarhaut,Brigitte Renoux,Fabrice Monti,Mickaël Tanteret al. European Journal of Medicinal Chemistry, 2017, 142, pp.2-7. ⟨10.1016/j.ejmech.2017.03.057⟩ Article dans une revue hal-02174984v1
Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers Brigitte Renoux,Florian Raes,Thibaut Legigan,Elodie Péraudeau,Balkis Eddhifet al. Chemical Science, 2017, 8 (5), pp.3427-3433. ⟨10.1039/C7SC00472A⟩ Article dans une revue hal-02174996v1
Diminished oligomerization in the synthesis of new anti-angiogenic cyclic peptide using solution instead of solid-phase cyclization S. Rubio,J. Clarhaut,E. Peraudeau,M. Vincenzi,C. Soumet al. Biopolymers, 2016, pp.368-375. ⟨10.1002/bip.22814⟩ Article dans une revue istex hal-01563735v1
A dendritic β-galactosidase-responsive folate–monomethylauristatin E conjugate Jérôme Alsarraf,Elodie Peraudeau,Pauline Poinot,I. Tranoy-Opalinski,Jonathan Clarhautet al. Chemical Communications, 2015, 51 (87), pp.15792-15795. ⟨10.1039/C5CC05294G⟩ Article dans une revue hal-03127679v1
Serotonin and Cancer: What Is the Link? Denis Sarrouilhe,Jonathan Clarhaut,Norah Defamie,Marc Mesnil Current Molecular Medicine, 2015, 15 (1), pp.62-77. ⟨10.2174/1566524015666150114113411⟩ Article dans une revue (article de synthèse) hal-04432521v1
A mechanically interlocked molecular system programmed for the delivery of an anticancer drug Romain Barat,Thibaut Legigan,I. Tranoy-Opalinski,Brigitte Renoux,Elodie Peraudeauet al. Chemical Science, 2015, 6 (4), pp.2608-2613. ⟨10.1039/c5sc00648a⟩ Article dans une revue hal-03127729v1
beta-Glucuronidase-responsive prodrugs for selective cancer chemotherapy: An update Isabelle Tranoy-Opalinski,Thibaut Legigan,Romain Barat,Jonathan Clarhaut,Mikael Thomaset al. European Journal of Medicinal Chemistry, 2014, 74, pp.302-313. ⟨10.1016/j.ejmech2013.12.045⟩ Article dans une revue hal-01196935v1
An enzyme-responsive system programmed for the double release of bioactive molecules through an intracellular chemical amplification process M. Grinda,T. Legigan,J. Clarhaut,E. Peraudeau,I. Tranoy-Opalinskiet al. Organic & Biomolecular Chemistry, 2013, 11 (41), pp.7129-7133. ⟨10.1039/c3ob41536h⟩ Article dans une revue hal-00966980v1
A galactosidase-responsive doxorubicin-folate conjugate for selective targeting of acute myelogenous leukemia blasts Jonathan Clarhaut,Sylvain Fraineau,Joëlle Guilhot,Elodie Péraudeau,Isabelle Tranoy-Opalinskiet al. Leukemia Research, 2013, 37 (8), pp.948 - 955. ⟨10.1016/j.leukres.2013.04.026⟩ Article dans une revue istex inserm-02444614v1
A chimerical phagocytosis model reveals the recruitment by Sertoli cells of autophagy for the degradation of ingested illegitimate substrates Marina Yefimova,Nadia Messaddeq,Thomas Harnois,Annie-Claire Meunier,Jonathan Clarhautet al. Autophagy, 2013, 9 (5), pp.653-666. ⟨10.4161/auto.23839⟩ Article dans une revue hal-03119928v1
Saturated fatty acids alter the late secretory pathway by modulating membrane properties. Laurie-Anne Payet,Ludovic Pineau,Ellen C R Snyder,Jenny Colas,Ahmed Moussaet al. Traffic, 2013, 14 (12), pp.1228-41. ⟨10.1111/tra.12117⟩ Article dans une revue hal-00990166v1
Synthesis and biological evaluations of a monomethylauristatin E glucuronide prodrug for selective cancer chemotherapy Thibaut Legigan,Jonathan Clarhaut,Brigitte Renoux,Isabelle Tranoy-Opalinski,Arnaud Monvoisinet al. European Journal of Medicinal Chemistry, 2013, 67, pp.75-80. ⟨10.1016/j.ejmech.2013.06.037⟩ Article dans une revue (data paper) istex hal-04033523v1
Down-regulation of Connexin43 expression reveals the involvement of caveolin-1 containing lipid rafts in human U251 glioblastoma cell invasion. Pierre-Olivier Strale,Jonathan Clarhaut,Coralie Lamiche,Laurent Cronier,Marc Mesnilet al. Molecular Carcinogenesis, 2012, 51 (11), pp.845-60. ⟨10.1002/mc.20853⟩ Article dans une revue istex hal-00993046v1
Synthesis and Antitumor Efficacy of a β-Glucuronidase-Responsive Albumin-Binding Prodrug of Doxorubicin. Thibaut Legigan,Jonathan Clarhaut,Brigitte Renoux,Isabelle Tranoy-Opalinski,Arnaud Monvoisinet al. Journal of Medicinal Chemistry, 2012, 55 (9), pp.4516-20. ⟨10.1021/jm300348r⟩ Article dans une revue hal-00710692v1
A self-immolative dendritic glucuronide prodrug of doxorubicin Marion Grinda,J. Clarhaut,Brigitte Renoux,Isabelle Tranoy-Opalinski,Sébastien Papot MedChemComm, 2012, 3 (1), pp.68-70. ⟨10.1039/c1md00193k⟩ Article dans une revue hal-00682705v1
The gap junction protein Cx43 is involved in the bone-targeted metastatic behaviour of human prostate cancer cells. Coralie Lamiche,Jonathan Clarhaut,Pierre-Olivier Strale,Sophie Crespin,Nathalie Pedrettiet al. Clinical and Experimental Metastasis, 2012, 29 (2), pp.111-22. ⟨10.1007/s10585-011-9434-4⟩ Article dans une revue istex hal-00993073v1
The vitamin K–dependent anticoagulant factor, protein S, inhibits multiple VEGF-A–induced angiogenesis events in a Mer- and SHP2-dependent manner Sylvain Fraineau,Arnaud Monvoisin,Jonathan Clarhaut,Julie Talbot,Claire Simonneauet al. Blood, 2012, 120 (25), pp.5073-5083. ⟨10.1182/blood-2012-05-429183⟩ Article dans une revue inserm-02444598v1
The First Generation of β-Galactosidase-Responsive Prodrugs Designed for the Selective Treatment of Solid Tumors in Prodrug Monotherapy Thibaut Legigan,Jonathan Clarhaut,Isabelle Tranoy-Opalinski,Arnaud Monvoisin,Brigitte Renouxet al. Angewandte Chemie International Edition, 2012, 51, pp.1 - 6. ⟨10.1002/anie.201204935⟩ Article dans une revue istex hal-00736090v1
A Heterodimeric Glucuronide Prodrug for Cancer Tritherapy: the Double Role of the Chemical Amplifier Marion Grinda,Jonathan Clarhaut,Isabelle Tranoy-Opalinski,Brigitte Renoux,Arnaud Monvoisinet al. ChemMedChem, 2011, 6 (12), pp.2137-2141. ⟨10.1002/cmdc.201100355⟩ Article dans une revue (data paper) istex hal-04033576v1
A Galactosidase‐Responsive “Trojan Horse” for the Selective Targeting of Folate Receptor‐Positive Tumor Cells Mickaël Thomas,Jonathan Clarhaut,Pierre-Olivier Strale,Isabelle Tranoy-Opalinski,Joëlle Rocheet al. ChemMedChem, 2011, 6 (6), pp.1006-1010. ⟨10.1002/cmdc.201100114⟩ Article dans une revue istex hal-05326356v1
Effect of endothelin-1 on osteoblastic differentiation is modified by the level of connexin43: comparative study on calvarial osteoblastic cells isolated from Cx43+/- and Cx43+/+ mice. Graziello Geneau,Coralie Lamiche,Corinne Niger,Pierre-Olivier Strale,Jonathan A. Clarhautet al. Cell and Tissue Research, 2010, 340 (1), pp.103-15. ⟨10.1007/s00441-009-0924-5⟩ Article dans une revue istex hal-00498245v1
Optimal design of dependable control system architectures using temporal sequences of failures J Clarhaut,B Conrard,S Hayat,V Cocquempot IEEE Transactions on Reliability, 2009, Vol 58, Issue 3, p511-522. ⟨10.1109/TR.2009.2026790⟩ Article dans une revue hal-00952035v1
ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells. Jonathan A. Clarhaut,Robert M. Gemmill,Vincent A. Potiron,Slimane Ait-Si-Ali,Jean Imbertet al. Neoplasia, 2009, 11 (2), pp.157-166. ⟨10.1593/neo.81074⟩ Article dans une revue hal-00416521v1
Synthesis and Modeling of New Benzofuranone Histone Deacetylase Inhibitors that Stimulate Tumor Suppressor Gene Expression Cédric Charrier,Jonathan A. Clarhaut,Jean-Pierre Gesson,Guillermina Estiu,Olaf Wiestet al. Journal of Medicinal Chemistry, 2009, 52, pp.3112-3115. ⟨10.1021/jm9002439⟩ Article dans une revue hal-00438795v1
Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy. Mickaël Thomas,Jonathan A. Clarhaut,Isabelle Tranoy-Opalinski,Jean-Pierre Gesson,Joëlle Rocheet al. Bioorganic and Medicinal Chemistry, 2008, 16 (17), pp.8109-8116. ⟨10.1016/j.bmc.2008.07.048⟩ Article dans une revue istex hal-00458881v1
Semaphorin, neuropilin and VEGF expression in glial tumours: SEMA3G, a prognostic marker? Lucie Karayan-Tapon,Michel Wager,Joëlle Guilhot,Pierre Levillain,C. Marquantet al. British Journal of Cancer, 2008, 99 (7), pp.1153-1160. ⟨10.1038/sj.bjc.6604641⟩ Article dans une revue hal-00458867v1
Semaphorin SEMA3F affects multiple signaling pathways in lung cancer cells Vincent A. Potiron,Girish Sharma,Patrick Nasarre,Jonathan A. Clarhaut,Hellmut G. Augustinet al. Cancer Research, 2007, 67 (18), pp.8708-8715. ⟨10.1158/0008-5472.CAN-06-3612⟩ Article dans une revue hal-00416414v1
Design, synthesis and biological evaluation of 1,4-benzodiazepine-2,5-dione-based HDAC inhibitors Lynda Loudni,Joëlle Roche,Vincent Potiron,Jonathan Clarhaut,Christian Bachmannet al. Bioorganic and Medicinal Chemistry Letters, 2007, 17 (17), pp.4819-4823. ⟨10.1016/j.bmcl.2007.06.067⟩ Article dans une revue istex hal-05326359v1
semaphorins in lung cancer J. Clarhaut,J. Roche,H.A. Drabkin Journal of Thoracic Oncology, 2006, 1, pp.203-204. ⟨10.1016/S1556-0864(15)31568-9⟩ Article dans une revue hal-00078139v1