Julien Vignard Chargé de Recherche Classe Normale dans l'équipe &quot;Génotoxicité et Signalisation&quot; de l'UMR 1331 Toxalim, INRAE

Identifiants chercheurs

IdHAL :

julien-vignard

ORCID :

0000-0001-6379-1741

IdRef :

121176177

Présentation

Publications

Article dans une revue (42)

Molecular Dynamics and Quantum Chemical Insights into the Molecular Basis of Differential Toxicity of the Mycotoxin Deoxynivalenol (DON) and Its Microbial Derivatives DOM-1 and 3-epi-DON Kanhaya Lal,Julien Vignard,Gladys Mirey,Franck Jolibois,Isabelle P Oswaldet al. ACS Omega, 2026, 11 (6), pp.9575-9586. ⟨10.1021/acsomega.5c09756⟩ Article dans une revue hal-05495502v1
Comparison of different techniques for γH2AX/pH3 biomarkers quantification for chemical genotoxicity assessment Cynthia Recoules,Chloé Huertas,Julien Vignard,Marc Audebert Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2025, 906, pp.503878. ⟨10.1016/j.mrgentox.2025.503878⟩ Article dans une revue hal-05514863v1
Genotoxic interaction between deoxynivalenol and acrylamide Chloé Huertas,Aboubacar B Coulibaly,Delphine Payros,Marie Penary,Sylvie Puelet al. Food Research International, 2025, 214, pp.116633. ⟨10.1016/j.foodres.2025.116633⟩ Article dans une revue hal-05076454v1
More than a mutagenic Aflatoxin B1 precursor: The multiple cellular targets of Versicolorin A revealed by global gene expression analysis Carine Al-Ayoubi,Ophélie Rocher,Claire Naylies,Yannick Lippi,Julien Vignardet al. Environmental Pollution, 2024, 363, pp.125138. ⟨10.1016/j.envpol.2024.125138⟩ Article dans une revue hal-04835843v1
Mutagenicity and genotoxicity assessment of the emerging mycotoxin Versicolorin A, an Aflatoxin B1 precursor Carine Al-Ayoubi,Maria Alonso-Jauregui,Amaya Azqueta,Julien Vignard,Gladys Mireyet al. Environmental Pollution, 2023, 335, pp.122276. ⟨10.1016/j.envpol.2023.122276⟩ Article dans une revue hal-04202803v1
Dairy By-Products and Lactoferrin Exert Antioxidant and Antigenotoxic Activity on Intestinal and Hepatic Cells Inés Abad,Julien Vignard,Catherine Bouchenot,Dimitra Graikini,Laura Grasaet al. Foods, 2023, 12 (10), pp.2073. ⟨10.3390/foods12102073⟩ Article dans une revue hal-04112315v1
Food-grade titanium dioxide translocates across the buccal mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium Julien Vignard,Aurelie Pettes-Duler,Eric Gaultier,Christel Cartier,Laurent Weingartenet al. Nanotoxicology, 2023, 17 (4), pp.289-309. ⟨10.1080/17435390.2023.2210664⟩ Article dans une revue hal-04104748v1
Repeated exposure of Caco-2 versus Caco-2/HT29-MTX intestinal cell models to (nano)silver in vitro: Comparison of two commercially available colloidal silver products Kevin Gillois,Charlotte Stoffels,Mathilde Lévêque,Isabelle Fourquaux,Justine Blessonet al. Science of the Total Environment, 2021, 754, ⟨10.1016/j.scitotenv.2020.142324⟩ Article dans une revue hal-02945727v1
Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response Benoît J Pons,Aurélie Pettes-Duler,Claire Naylies,Frédéric Taieb,Catherine Bouchenotet al. Cellular and Molecular Life Sciences, 2021, 78 (17-18), pp.6319-6335. ⟨10.1007/s00018-021-03902-x⟩ Article dans une revue hal-03306242v1
Cytolethal Distending Toxin Promotes Replicative Stress Leading to Genetic Instability Transmitted to Daughter Cells William Tremblay,Florence Mompart,Elisa Lopez,Muriel Quaranta,Valérie Bergoglioet al. Frontiers in Cell and Developmental Biology, 2021, 9, pp.1-15. ⟨10.3389/fcell.2021.656795⟩ Article dans une revue hal-03248449v1
Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B Benoît Pons,Nicolas Loiseau,Saleha Hashim,Souria Tadrist,Gladys Mireyet al. Toxins, 2020, 12 (9), pp.530. ⟨10.3390/toxins12090530⟩ Article dans une revue hal-02927138v1
Versicolorin A, a precursor in aflatoxins biosynthesis, is a food contaminant toxic for human intestinal cells Thierry Gauthier,Carolina Duarte-Hospital,Julien Vignard,Elisa Boutet-Robinet,Michael Sulyoket al. Environment International, 2020, 137, 15 p. ⟨10.1016/j.envint.2020.105568⟩ Article dans une revue hal-02556860v1
Cell transfection of purified cytolethal distending toxin B subunits allows comparing their nuclease activity while plasmid degradation assay does not Benoît Pons,Elisabeth Bezine,Mélissa Hanique,Valerie Guillet,Lionel Moureyet al. PLoS ONE, 2019, 14 (3), pp.e0214313. ⟨10.1371/journal.pone.0214313⟩ Article dans une revue hal-02346660v1
Cytolethal distending toxin subunit B: A review of structure–function relationship Benoît Pons,Julien Vignard,Gladys Mirey Toxins, 2019, 11 (10), 20 p. ⟨10.3390/toxins11100595⟩ Article dans une revue hal-02618477v1
Exposure to the fungicide captan induces DNA base alterations and replicative stress in mammalian cells Anne Fernandez-Vidal,Liana C. Arnaud,Manon Maumus,Marianne Chevalier,Gladys Mireyet al. Environmental and Molecular Mutagenesis, 2019, 60 (3), pp.286-297. ⟨10.1002/em.22268⟩ Article dans une revue hal-02620276v1
A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2 Alan D. d'Andrea,Laure Guitton-Sert,Mariline Béliveau,Kalindi Parmar,Jalila Chagraouiet al. Nucleic Acids Research, 2019, 47 (14), pp.7532-7547. ⟨10.1093/nar/gkz514⟩ Article dans une revue hal-02915101v1
&lt;em&gt;Campylobacter jejuni&lt;/em&gt; promotes colorectal tumorigenesis through the action of cytolethal distending toxin Zhen He,Raad Z. Gharaibeh,Rachel C. Newsome,Jllian L. Pope,Michael W. Doughertyet al. Gut, 2019, 68 (2), pp.289-300. ⟨10.1136/gutjnl-2018-317200⟩ Article dans une revue hal-02627995v1
Genotoxicity and mutagenicity assessment of food contaminant mixtures present in the French diet Benjamin Kopp,Julien Vignard,Gladys Mirey,Valérie Fessard,Daniel Zalkoet al. Environmental and Molecular Mutagenesis, 2018, 59 (8), pp.1-13. ⟨10.1002/em.22214⟩ Article dans une revue anses-01880114v1
The colibactin genotoxin generates DNA interstrand cross-links in infected cells Nadège Bossuet-Greif,Julien Vignard,Frederic Taieb,Gladys Mirey,Damien Duboiset al. mBio, 2018, 9 (2), pp.e02393-17. ⟨10.1128/mBio.02393-17⟩ Article dans une revue hal-02627565v1
Use of a reliable metabolically competent human rghep(+) hepatocyte model engineered with biological tracers for in vitro micronucleus test associating high-content imaging&lt;strong&gt;&lt;/strong&gt; Vanessa Graillot,Thibault Metenier,Odile Mondésert,Julien Vignard,Valérie Lobjoiset al. Drug Metabolism and Pharmacokinetics, 2018, 33 (1), pp.S59. ⟨10.1016/j.dmpk.2017.11.200⟩ Article dans une revue istex hal-02618768v1
Benzo[a]pyrene-induced DNA damage associated with mutagenesis in primary human activated T lymphocytes Marie Liamin,Elisa Boutet-Robinet,Emilien L. Jamin,Morgane Fernier,Laure Khouryet al. Biochemical Pharmacology, 2017, 137, pp.113-124. ⟨10.1016/j.bcp.2017.04.025⟩ Article dans une revue hal-01560145v1
Around and beyond 53BP1 nuclear bodies Anne Fernandez-Vidal,Julien Vignard,Gladys Mirey International Journal of Molecular Sciences, 2017, 18 (12), ⟨10.3390/ijms18122611⟩ Article dans une revue hal-02619788v1
A new in vitro micronucleus test in living cells associating biological tracers and high-content imaging Vanessa Graillot,Odile Mondésert,Thibault Metenier,Julien Vignard,Valerie Lobjoiset al. Toxicology Letters, 2016, 258, pp.S146. ⟨10.1016/j.toxlet.2016.06.1566⟩ Article dans une revue istex hal-01602870v1
Genotoxicity of cytolethal distending toxin (cdt) on isogenic human colorectal cell lines: potential promoting effects for colorectal carcinogenesis Vanessa Graillot,Inge Dormoy,Jacques Dupuy,Jerry W. Shay,Laurence Hucet al. Frontiers in Cellular and Infection Microbiology, 2016, 6, pp.1-13. ⟨10.3389/fcimb.2016.00034⟩ Article dans une revue hal-02635460v1
Cell resistance to the cytolethal distending toxin involves an association of DNA repair mechanisms Elisabeth Bezine,Yann Malaisé,Aurore Loeuillet,Marianne Chevalier,Elisa Boutet-Robinetet al. Scientific Reports, 2016, 6, pp.1-15. ⟨10.1038/srep36022⟩ Article dans une revue hal-01602345v1
Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells Denis Jullien,Julien Vignard,Yoann Fedor,Nicolas Béry,Aurélien Olichonet al. Development (Cambridge, England), 2016, 143 (14), ⟨10.1242/dev.141804⟩ Article dans une revue hal-01602858v1
Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells Denis Jullien,Julien Vignard,Yoann Fedor,Nicolas Béry,Aurélien Olichonet al. Journal of Cell Science, 2016, 129 (13), pp.2673-2683. ⟨10.1242/jcs.183103⟩ Article dans une revue hal-01602848v1
The cytolethal distending toxin effects on Mammalian cells: a DNA damage perspective. Elisabeth Bezine,Julien Vignard,Gladys Mirey Cells, 2014, 3 (2), pp.592-615. ⟨10.3390/cells3020592⟩ Article dans une revue hal-01192559v1
Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up Julien Vignard,Gladys Mirey,Bernard Salles Radiotherapy & Oncology, 2013, 108 (3), pp.362-369. ⟨10.1016/j.radonc.2013.06.013⟩ Article dans une revue hal-02648277v1
From single-strand breaks to double-strand breaks during S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin Yoann Fedor,Julien Vignard,Marie-Laure Travers,Elisa Boutet-Robinet,Claude Watrinet al. Cellular Microbiology, 2013, 15 (1), pp.1 - 15. ⟨10.1111/cmi.12028⟩ Article dans une revue hal-02647902v1
PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks Jana Krietsch,Marie Christine Caron,Jean-Philippe Gagné,Chantal Ethier,Julien Vignardet al. Nucleic Acids Research, 2012, 40 (20), pp.10287-301. ⟨10.1093/nar/gks798⟩ Article dans une revue hal-01137043v1
Partners apart: Smc6-independent DNA binding activity of Smc5 on single-strand DNA Julien Vignard,Corinne Charbonnel,Jean-Yves Masson Cell Cycle, 2011, 10 (7), pp.1025-1026. ⟨10.4161/cc.10.7.15212⟩ Article dans une revue hal-02643095v1
SHOC1 and PTD form an XPF-ERCC1-like complexthat is required for formation of class I crossovers Nicolas N. Macaisne,Julien Vignard,Raphaël R. Mercier Journal of Cell Science, 2011, 124 (Pt 16), pp.2687-2691. ⟨10.1242/jcs.088229⟩ Article dans une revue hal-01000742v1
Very-long-chain fatty acids are involved in polar auxin transport and developmental patterning in Arabidopsis François Roudier,Lionel Gissot,Frédéric Beaudoin,Richard Haslam,Louise V. Michaelsonet al. The Plant cell, 2010, 22 (2), pp.364-375. ⟨10.1105/tpc.109.071209⟩ Article dans une revue hal-00856101v1
The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses. Ramachander V. N. Turaga,Eric R. Paquet,Mari Sild,Julien Vignard,Chantal Garandet al. Cell Cycle, 2009, 8 (13), pp.2080-2092. ⟨10.4161/cc.8.13.8925⟩ Article dans une revue hal-02655604v1
MRE11–RAD50–NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair Céline Roques,Yan Coulombe,Mathieu Delannoy,Julien Vignard,Simona Grossiet al. EMBO Journal, 2009, 28 (16), pp.2400-2413. ⟨10.1038/emboj.2009.193⟩ Article dans une revue hal-02662125v1
Outcrossing as an explanation of the apparent unconventional genetic behavior of &lt;em&gt;Arabidopsis thaliana&lt;/em&gt; hth mutants Raphaël Mercier,Sylvie Jolivet,Julien Vignard,Stéphanie Durand,Jan Drouaudet al. Genetics, 2008, 180 (4), pp.2295-2297. ⟨10.1534/genetics.108.095208⟩ Article dans une revue hal-02656582v1
AtMSH5 partners AtMSH4 in the class I meiotic crossover pathway in &lt;em&gt;Arabidopsis thaliana&lt;/em&gt;, but is not required for synapsis James D. Higgins,Julien Vignard,Raphaël Mercier,Alice G. Pugh,F. Chris H. Franklinet al. The Plant Journal, 2008, 55 (1), pp.28-39. ⟨10.1111/j.1365-313X.2008.03470.x⟩ Article dans une revue hal-02661925v1
The road to crossovers: plants have their say Christine Mézard,Julien Vignard,Jan Drouaud,Raphaël Mercier Trends in Genetics, 2007, 23 (2), pp.91-99. ⟨10.1016/j.tig.2006.12.007⟩ Article dans une revue (article de synthèse) hal-02668854v1
The interplay of RecA-related proteins and the MND1-HOP2 complex during meiosis in &lt;em&gt;Arabidopsis thaliana&lt;/em&gt; Julien Vignard,Tanja Siwiec,Liudmila Chelysheva,Nathalie Vrielynck,Florine Gonordet al. PLoS Genetics, 2007, 3 (10), pp.1894-906. ⟨10.1371/journal.pgen.0030176⟩ Article dans une revue hal-02661109v1
Alterations in sphingolipid synthesis in the model plant Arabidopsis thaliana is associated with cell polarity and developmental defects François Roudier,Lionel L. Gissot,Julien Vignard,Christine Rochat,Patrick Moreauet al. Chemistry and Physics of Lipids, 2006, 143 (1-2), pp.100 Article dans une revue hal-02657873v1
The Arabidopsis thaliana MND1 homologue plays a key role in meiotic homologous pairing, synapsis and recombination C. Kerzendorfer,Julien Vignard,A. Pedrosa-Harand,T. Siwiec,S. Akimchevaet al. Journal of Cell Science, 2006, 119 (12), pp.2486-2496. ⟨10.1242/jcs.02967⟩ Article dans une revue hal-02664509v1

Brevet (1)

Anticorps monocaténaire à chaîne lourde de camelidae dirigé contre la chromatine et utilisations Denis Jullien,Julien Vignard,Bernard Salles,Gladys Mirey France, N° de brevet: x. 2013 Brevet hal-02807167v1

Chapitre d'ouvrage (1)

The effect of Cytolethal Distending Toxin from Gram-negative bacteria on mammalian cells. Elisabeth Bezine,Julien Vignard,Gladys Mirey Prokaryotes: Physiology, Biochemistry and Cell Behavior., Nova science, 2014 Chapitre d'ouvrage hal-02792518v1

Pré-publication, Document de travail (2)

More than a Mutagenic Aflatoxin B1 Precursor: The Multiple Cellular Targets of Versicolorin a Revealed by Global Gene Expression Analysis Carine Al-Ayoubi,Ophelie Rocher,Claire Nayles,Yannick Lippi,Julien Vignardet al. 2024 Pré-publication, Document de travail hal-04687397v1
Food-grade titanium dioxide translocates across the oral mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium Julien Vignard,Aurélie Pettes-Duler,Eric Gaultier,Christel Cartier,Laurent Weingartenet al. 2022 Pré-publication, Document de travail hal-03774152v1

Communication dans un congrès (7)

In vitro micronucleus test in living cells associating biological tracers and high-content imaging Gladys Mirey,Vanessa Graillot,Odile Mondésert,Thibault Metenier,Julien Vignardet al. 53. Congress of the European-Societies-of-Toxicology (EUROTOX), Sep 2017, Bratislava, Slovakia. pp.1, ⟨10.1016/j.toxlet.2017.08.072⟩ Communication dans un congrès istex hal-02735959v1
L’analyse des voies de réparation nous renseigne sur les dommages à l’ADN induits par la toxine CDT Elisabeth Bezine,Julien Vignard,Yann Malaisé,Aurore Loeuillet,Elisa Boutet-Robinetet al. Journée des doctorants de l'INRA Toxalim, Jun 2015, Toulouse, France Communication dans un congrès hal-02800134v1
The bacterial cytolethal distending Toxin induces indirect double-strand breaks into eukaryotic cells Elisabeth Bezine,Julien Vignard,Marianne Chevalier,Elisa Boutet-Robinet,Bernard Salleset al. Journée de l’ecole Doctorale SEVAB, Mar 2015, Toulouse, France Communication dans un congrès hal-02796083v1
Nanobody-based universal histone binding domains for chromatin imaging and editing Denis Jullien,Julien Vignard,Yoann Fedor,Aurélien Olichon,Michèle Crozatieret al. 4. Biosensor Meeting of the Biosensor Group of the GDR 2588 Microscopie et Imagerie du Vivant, May 2014, Bordeaux, France Communication dans un congrès hal-02793548v1
VHH-based universal histone binding domains: novel tools for a different look on and manipulation of chromatin Denis Jullien,Julien Vignard,Yoann Fedor,Aurélien Olichon,Bernard Salleset al. FEBS EMBO 2014 Conférence, Aug 2014, Paris, France. 823 p Communication dans un congrès hal-02741249v1
Genotoxicity and repair: the cytolethal distending toxin model Elisabeth Bezine,Yoann Fedor,Julien Vignard,Elisa Boutet-Robinet,Bernard Salleset al. 4? workshop "Genome, Structure and Functions", Hôpital Rangueil. FRA., Apr 2013, Toulouse, France Communication dans un congrès hal-02809832v1
Développement de nouveaux outils de détection non-invasive des cassures double brin de l’ADN Denis Jullien,Julien Vignard,Gladys Mirey,Bernard Ducommun Réunion du groupe Biosenseur GDR2588, Groupe Biosenseur GDR2588., Mar 2012, Montpellier, France Communication dans un congrès hal-02807599v1

Poster de conférence (12)

Human TR146 cells and pig buccal mucosa to assess oral transmucosal passage and buccal toxicity of foodgrade titanium dioxide Julien Vignard,Aurélie Pettes-Duler,Eric Gaultier,Christel Cartier,Laurent Weingartenet al. The XVIth International Congress of Toxicology, Sep 2022, Maastricht, Netherlands Poster de conférence hal-03778286v1
Charcuterie et nitrosylation du fer héminique : toxicité in vitro du fer nitrosylé. Jacques Dupuy,Julien Vignard,Tina Kostka,Gladys Mirey,Françoise Guéraudet al. Journées Francophones de Nutrition, Nov 2022, Toulouse, France Poster de conférence hal-04206466v1
Exposome alimentaire : la mycotoxine déoxynivalénol augmente la génotoxicité du fer héminique. Delphine Payros,Marion Garofalo,Michel Baker,Marie Penary,Julien Vignardet al. Journées Francophones de Nutrition, Nov 2022, Toulouse, France Poster de conférence hal-04206504v1
Cellular study of a bacterial DNA-damaging virulence factor, the cytolethal distending toxin Benoît Pons,Julien Vignard,Elisabeth Bezine,Saleha Hashim,Valérie Lobjoiset al. Young Life Scientists’ Symposium on Genome Integrity, Nov 2018, Montpellier, France. 2018 Poster de conférence hal-02787088v1
Cellular study of a bacterial DNA-damaging virulence factor, the Cytolethal Distending Toxin Benoît Pons,Julien Vignard,Elisabeth Bezine,Jean-Sébastien Dupuy,Saleha Hashimet al. EuroScience Open Forum, Jul 2018, Toulouse, France. , 2018 Poster de conférence hal-02789185v1
Cytolethal Distending Toxin (CDT) exhibits a unique ability to induce micronucleus in infected cells: possible implications regarding activation of the inflammatory response Julien Vignard,Benoît Pons,Anne Fernandez-Vidal,Gladys Mirey DINGO, Jun 2018, Paris, France. , 2018 Poster de conférence hal-02790628v1
Overview of the DNA repair pathways involved in the response to the cytolethal distending toxin Julien Vignard,Elisabeth Bezine,Gladys Mirey,Bernard Salles,Elisa Boutet-Robinetet al. 11th 3R Meeting, May 2015, Giens, France. pp.1, 2015 Poster de conférence hal-02793078v1
Overview of the DNA repair pathways involved in response to the cytolethal distending toxin Elisabeth Bezine,Julien Vignard,Marianne Chevalier,Elisa Boutet-Robinet,Bernard Salleset al. The 6th EMBO Meeting, Sep 2015, Birmingham, United Kingdom. 2015 Poster de conférence hal-02740247v1
The bacterial cytolethal distending toxin: a nuclease inducing indirect DNA double-strand breaks into eukaryotic cells Elisabeth Bezine,Yoann Fedor,Julien Vignard,Elisa Boutet-Robinet,Bernard Salleset al. FEBS EMBO 2014 Conférence, Aug 2014, Paris, France. 2014 Poster de conférence hal-02740249v1
A new mode of action of a bacterial genotoxin: the cytolethal distending toxin Elisabeth Bezine,Yoann Fedor,Julien Vignard,Elisa Boutet-Robinet,Bernard Salleset al. Journée Ecole Doctorale SEVAB, Nov 2013, Toulouse, France. 2013 Poster de conférence hal-02806633v1
A new mode of action for the cytolethal distending toxin Elisabeth Bezine,Yoann Fedor,Julien Vignard,Elisa Boutet-Robinet,Bernard Salleset al. 5. EMBO Meeting, Sep 2013, Amsterdam, Netherlands. 2013 Poster de conférence hal-02748175v1
Effets génotoxiques de la cytolethal distending toxin et mécanismes de signalisations Elisabeth Bezine,Yoann Fedor,Julien Vignard,Elisa Boutet-Robinet,Bernard Salleset al. Journées des Microbiologistes de l’INRA 2012, Nov 2012, Avignon, France. 2012 Poster de conférence hal-02746646v1