Kai Wengelnik

Publications

Article dans une revue (20)

PI3-kinase has multiple functions in asexual blood stages of Plasmodium falciparum Reem Al Monla,Maria Penzo,Alice Vallentin,Rakhee Lohia,Jeremy Vincentet al. Scientific Reports, 2025, 15 (1), pp.16762. ⟨10.1038/s41598-025-01397-1⟩ Article dans une revue hal-05374945v1
An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP Marie Ali,Rea Dura,Marc-Antoine Guery,Emma Colard-Itté,Thomas Chevietet al. Science Advances , 2025, 11 (47), pp.eady2859. ⟨10.1126/sciadv.ady2859⟩ Article dans une revue hal-05387607v1
Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion Rakhee Lohia,Benoit Allegrini,Laurence Berry,Hélène Guizouarn,Rachel Cerdanet al. Cellular and Molecular Life Sciences, 2023, 80 (5), pp.124. ⟨10.1007/s00018-023-04773-0⟩ Article dans une revue hal-04094157v1
Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection Shang Ma,Stuart Cahalan,Gregory Lamonte,Nathan Grubaugh,Weizheng Zenget al. Cell, 2018, 173 (2), pp.443-455.e12. ⟨10.1016/j.cell.2018.02.047⟩ Article dans une revue hal-03246965v1
Phosphoinositides and their functions in apicomplexan parasites Kai Wengelnik,Wassim Daher,Maryse Lebrun International Journal for Parasitology, 2018, 48 (7), pp.493-504. ⟨10.1016/j.ijpara.2018.01.009⟩ Article dans une revue hal-03247070v1
Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite Sharon Wein,Salma Ghezal,Corinne Bure,Marjorie Maynadier,Christian Perigaudet al. Journal of Lipid Research, 2018, 59 (8), pp.1461-1471. ⟨10.1194/jlr.M085589⟩ Article dans une revue hal-02535449v1
High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death Sharon Wein,Nicolas Taudon,Marjorie Maynadier,Christophe Tran van Ba,Delphine Margoutet al. Antimicrobial Agents and Chemotherapy, 2017, 61 (8), pp.00352-17. ⟨10.1128/AAC.00352-17⟩ Article dans une revue hal-04596614v1
Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes Ellen Bushell,Ana Rita Gomes,Theo Sanderson,Burcu Anar,Gareth Girlinget al. Cell, 2017, 170 (2), pp.260-272.e8. ⟨10.1016/j.cell.2017.06.030⟩ Article dans une revue (data paper) hal-04243702v1
Lipid kinases are essential for apicoplast homeostasis in T oxoplasma gondii Wassim Daher,Juliette Morlon-Guyot,Lilach Sheiner,Gaëlle Lentini,Laurence Berryet al. Cellular Microbiology, 2015, 17 (4), pp.559-578. ⟨10.1111/cmi.12383⟩ Article dans une revue hal-03246901v1
Plasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP-choline analog selected from a virtual screening Alicia Contet,Émilie Pihan,Marina Lavigne,Kai Wengelnik,Sweta Maheshwariet al. FEBS Letters, 2015, 589 (9), pp.992-1000. ⟨10.1016/j.febslet.2015.03.003⟩ Article dans une revue hal-02115813v1
Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active Sweta Maheshwari,Marina Lavigne,Alicia Contet,Blandine Alberge,Émilie Pihanet al. Biochemical Journal, 2013, 450 (1), pp.159-167. ⟨10.1042/BJ20121480⟩ Article dans une revue hal-02115788v1
Multiple roles for Plasmodium berghei phosphoinositide-specific phospholipase C in regulating gametocyte activation and differentiation Andreas Raabe,Kai Wengelnik,Oliver Billker,Henri Vial Cellular Microbiology, 2011, 13 (7), pp.955-966. ⟨10.1111/j.1462-5822.2011.01591.x⟩ Article dans une revue hal-03246892v1
Phosphatidylinositol 3-Monophosphate Is Involved in Toxoplasma Apicoplast Biogenesis Lina Tawk,Jean-François Dubremetz,Philippe Montcourrier,Gaëtan Chicanne,Fabrice Merezegueet al. PLoS Pathogens, 2011, 7 (2), pp.e1001286. ⟨10.1371/journal.ppat.1001286⟩ Article dans une revue hal-03246879v1
Genetic and transcriptional analysis of phosphoinositide-specific phospholipase C in Plasmodium Andreas Raabe,Laurence Berry,Lauriane Sollelis,Rachel Cerdan,Lina Tawket al. Experimental Parasitology, 2011, 129 (1), pp.75-80. ⟨10.1016/j.exppara.2011.05.023⟩ Article dans une revue hal-04121786v1
The Kennedy phospholipid biosynthesis pathways are refractory to genetic disruption in Plasmodium berghei and therefore appear essential in blood stages Sandrine Déchamps,Kai Wengelnik,Laurence Berry-Sterkers,Rachel Cerdan,Henri Vialet al. Molecular and Biochemical Parasitology, 2010, 173 (2), pp.69-80. ⟨10.1016/j.molbiopara.2010.05.006⟩ Article dans une revue hal-02281791v1
Phosphatidylinositol 3-Phosphate, an Essential Lipid in Plasmodium, Localizes to the Food Vacuole Membrane and the Apicoplast Lina Tawk,Gaëtan Chicanne,Jean-François Dubremetz,Véronique Richard,Bernard Payrastreet al. Eukaryotic Cell, 2010, 9 (10), pp.1519-1530. ⟨10.1128/EC.00124-10⟩ Article dans une revue hal-03246870v1
Quantitative assessment of DNA replication to monitor microgametogenesis in Plasmodium berghei Andreas Raabe,Oliver Billker,Henri Vial,Kai Wengelnik Molecular and Biochemical Parasitology, 2009, 168 (2), pp.172-176. ⟨10.1016/j.molbiopara.2009.08.004⟩ Article dans une revue hal-03246862v1
A new class of potent antimalarials and their specific accumulation in infected erythrocytes Kai Wengelnik Science, 2002 Article dans une revue hal-04596787v1
Characterization of Plasmodium falciparum CDP-diacylglycerol synthase, a proteolytically cleaved enzyme Dominique P. Martin,Leila Gannoun-Zaki,Serge Bonnefoy,Patrick Eldin,Kai Wengelniket al. Molecular and Biochemical Parasitology, 2000, 110 (1), pp.93-105. ⟨10.1016/s0166-6851(00)00260-7⟩ Article dans une revue istex hal-02281921v1
The A-domain and the thrombospondin-related motif of Plasmodium falciparum TRAP are implicated in the invasion process of mosquito salivary glands K. Wengelnik EMBO Journal, 1999, 18 (19), pp.5195-5204. ⟨10.1093/emboj/18.19.5195⟩ Article dans une revue hal-03246848v1

Communication dans un congrès (1)

The two first steps of the Kennedy phosphatidylcholine pathway are essential for the survival of the malaria parasite Quentin Chevalier,Corinne Buré,Coralie Duclovel,Alicia da Silva,Kai Wengelniket al. 18th GERLI Lipid Meeting. Lipids: from molecular aspects to human diseases, Groupe d'étude et de Recherche en Lipidomique (GERLI), Oct 2023, Paris, centre de recherche des cordeliers, France Communication dans un congrès hal-05156842v1

Poster de conférence (1)

The lysophosphatidylcholine is an essential and versatile source for de novo phospholipids' biosynthesis in Plasmodium falciparum Quentin Chevalier,Corinne Buré,Coralie Duclovel,Alicia da Silva,Kai Wengelniket al. EMBO Workshop: "New frontiers in host-parasite interactions, from cell to organism", Oct 2022, Six-Four-Les Plages, Les Embiez, France. Poster de conférence hal-05156868v1