Larbi Amazit

Publications

Article dans une revue (23)

A novel mutation in the NR3C1 gene associated with reversible glucocorticoid resistance Margaux Laulhé,Emmanuelle Kuhn,Jérôme Bouligand,Larbi Amazit,Julie Perrotet al. European Journal of Endocrinology, 2024, 190 (4), pp.284-295. ⟨10.1093/ejendo/lvae031⟩ Article dans une revue hal-04566600v1
Characterization of a novel variant in the NR3C1 gene: differentiating glucocorticoid resistance from Cushing Syndrome Margaux Laulhé,Michal Yacobi Bach,Julie Perrot,Michal Gershinsky,Jérôme Fagartet al. Journal of Clinical Endocrinology and Metabolism, 2024, ⟨10.1210/clinem/dgae829⟩ Article dans une revue hal-04811957v1
Conséquence de la perte fonctionnelle de la lysine déméthylase KDM1A sur la méthylation des histones, la conformation chromatinienne et expression génique dans l’hyperplasie macronodulaire bilatérale des surrénales GIP-dépendante F. Chasseloup,L. Syx,K. Ancelin,N. Ladurelle,L. Amazitet al. Annales d'Endocrinologie = Annals of Endocrinology, 2024, 85 (5), pp.375-376. ⟨10.1016/j.ando.2024.08.084⟩ Article dans une revue hal-04720090v1
Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells Benjamin Le Vely,Carole Phan,Nihel Berrebeh,Raphaël Thuillet,Mina Ottavianiet al. American Journal of Respiratory Cell and Molecular Biology, 2022, Online ahead of print. ⟨10.1165/rcmb.2021-0332oc⟩ Article dans une revue inserm-03678207v1
Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells Benjamin Le Vely,Carole Phan,Nihel Berrebeh,Raphaël Thuillet,Mina Ottavianiet al. American Journal of Respiratory Cell and Molecular Biology, 2022, 67 (2), pp.215-226. ⟨10.1165/rcmb.2021-0332OC⟩ Article dans une revue hal-04608774v1
The mineralocorticoid receptor modulates timing and location of genomic binding by glucocorticoid receptor in response to synthetic glucocorticoids in keratinocytes Elena Carceller-Zazo,Lisa Sevilla,Omar Pons-Alonso,Álvaro Chiner-Oms,Larbi Amazitet al. FASEB Journal, 2022, 37 (1), pp.e22709. ⟨10.1096/fj.202201199RR⟩ Article dans une revue hal-04292010v1
Loss of KDM1A in GIP-dependent primary bilateral macronodular adrenal hyperplasia with Cushing's syndrome: a multicentre, retrospective, cohort study Fanny Chasseloup,Isabelle Bourdeau,Antoine Tabarin,Daniela Regazzo,Charles Dumontetet al. The Lancet. Diabetes & Endocrinology , 2021, 9 (12), pp.813-824. ⟨10.1016/S2213-8587(21)00236-9⟩ Article dans une revue hal-03688894v1
Expanding the phenotype of mitochondrial disease: Novel pathogenic variant in ISCA1 leading to instability of the iron-sulfur cluster in the protein E Lebigot,M Hully,L Amazit,P Gaignard,T Michelet al. Mitochondrion, 2020, ⟨10.1016/j.mito.2020.02.008⟩ Article dans une revue hal-02971951v1
Crosstalk Between Glucocorticoid Receptor and Early-growth Response Protein 1 Accounts for Repression of Brain-derived Neurotrophic Factor Transcript 4 Expression Hui Chen,Larbi Amazit,Marc Lombès,Damien Le Menuet Neuroscience, 2019, 399, pp.12-27. ⟨10.1016/j.neuroscience.2018.12.012⟩ Article dans une revue inserm-02298752v1
ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure Clémence Delcour,Larbi Amazit,Liliana Patino,Françoise Magnin,Jérôme Fagartet al. Genetics in Medicine, 2019, 21 (4), pp.930-938. ⟨10.1038/s41436-018-0287-y⟩ Article dans une revue hal-04319232v1
Functional Characterization of Glucocorticoid Receptor Variants Is Required to Avoid Misinterpretation of NGS Data Loïc Foussier,Géraldine Vitellius,Jérôme Bouligand,Larbi Amazit,Claire Bouvattieret al. Journal of the Endocrine Society, 2019, 3 (5), pp.865-881. ⟨10.1210/js.2019-00028⟩ Article dans une revue hal-04319239v1
Corticosteroid receptors adopt distinct cyclical transcriptional signatures Florian Le Billan,Larbi Amazit,Kevin Bleakley,Qiong-Yao Xue,Eric Pussardet al. FASEB Journal, 2018, 32 (10), pp.5626-5639. ⟨10.1096/fj.201800391RR⟩ Article dans une revue hal-01960262v1
HuR-Dependent Editing of a New Mineralocorticoid Receptor Splice Variant Reveals an Osmoregulatory Loop for Sodium Homeostasis Ingrid J. Lema,Larbi Amazit,Khadija Lamribet,Jérome Fagart,Anne Blanchardet al. Scientific Reports, 2017, 7 (1), pp.4835. ⟨10.1038/s41598-017-04838-8⟩ Article dans une revue hal-02459152v1
RNA-binding protein HuR enhances mineralocorticoid signaling in renal KC3AC1 cells under hypotonicity Ingrid J. Lema,Larbi Amazit,Khadija Lamribet,Jérome Fagart,Anne Blanchardet al. Cellular and Molecular Life Sciences, 2017, 74 (24), pp.4587-4597. ⟨10.1007/s00018-017-2594-x⟩ Article dans une revue hal-02459157v1
Identifying mitotane-induced mitochondria-associated membranes dysfunctions : metabolomic and lipidomic approaches Segolene Hescot,Larbi Amazit,Marie Lhomme,Simon Travers,Anais Dubowet al. Oncotarget, 2017, Epub ahead of print. ⟨10.18632/oncotarget.18968⟩ Article dans une revue inserm-01568757v1
Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins. Lina Mouna,Eva Hernandez,Dorine Bonte,Rebekka Brost,Larbi Amazitet al. Autophagy, 2016, 12 (2), pp.327-42. ⟨10.1080/15548627.2015.1125071⟩ Article dans une revue hal-01344313v1
Finerenone impedes aldosterone-dependent nuclear import of the mineralocorticoid receptor and prevents genomic recruitment of steroid receptor coactivator-1 L. Amazit,Florian Le Billan,Peter Kolkhof,Khadija Lamribet,Say Viengchareunet al. Journal of Biological Chemistry, 2015, ⟨10.1074/jbc.M115.657957⟩ Article dans une revue hal-03464100v1
Ligand-dependent degradation of SRC-1 is pivotal for progesterone receptor transcriptional activity. Larbi Amazit,Audrey Rouseau,Junaid Ali Khan,Anne Chauchereau,Rakesh K. Tyagiet al. Molecular Endocrinology -Baltimore-, 2011, 25 (3), pp.394-408. ⟨10.1210/me.2010-0458⟩ Article dans une revue inserm-00554408v1
p38 and p42/44 MAPKs Differentially Regulate Progesterone Receptor A and B Isoform Stabilization. Junaid Ali Khan,Larbi Amazit,Catherine Bellance,Anne Guiochon-Mantel,Marc Lombeset al. Mol Endocrinol, 2011, 25 (10), pp.1710-24. ⟨10.1210/me.2011-1042⟩ Article dans une revue inserm-00611160v1
Familial glucocorticoid receptor haploinsufficiency by non-sense mediated mRNA decay, adrenal hyperplasia and apparent mineralocorticoid excess. Jérôme Bouligand,Brigitte Delemer,Annie-Claude Hecart,Géri Meduri,Say Viengchareunet al. PLoS ONE, 2010, 5 (10), pp.e13563. ⟨10.1371/journal.pone.0013563⟩ Article dans une revue inserm-00524824v1
Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. Jean-Francois Louet,Agnès Coste,Larbi Amazit,Mounia Tannour-Louet,Ray-Chang Wuet al. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (47), pp.17868-73. ⟨10.1073/pnas.0608711103⟩ Article dans une revue hal-00188030v1
Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells. Julien Grenier,Amalia Trousson,Anne Chauchereau,Larbi Amazit,Audrey Lamirandet al. Molecular Endocrinology -Baltimore-, 2004, 18 (12), pp.2866-79. ⟨10.1210/me.2004-0241⟩ Article dans une revue hal-01939763v1
Sumoylation of the Progesterone Receptor and of the Steroid Receptor Coactivator SRC-1 Anne Chauchereau,Larbi Amazit,Monique Quesne,Anne Guiochon-Mantel,Edwin Milgrom Journal of Biological Chemistry, 2003, 278 (14), pp.12335-12343. ⟨10.1074/jbc.M207148200⟩ Article dans une revue hal-03211073v1

Communication dans un congrès (2)

La perte de la lysine demethylase KDM1A est la cause de l’hyperplasie macronodulaire bilatérale des surrénales GIP-dépendante F. Chasseloup,I. Bourdeau,A. Tabarin,D. Regazzo,C. Dumontetet al. 38e Congrès SFE, SFE, Oct 2022, Nantes (France), France. pp.320-321, ⟨10.1016/j.ando.2022.07.115⟩ Communication dans un congrès hal-04942842v1
Les approches lipidomiques et metabolomiques identifient les MAM (mitochondria-associated membranes) comme cible du mitotane. S. Hescot,J. Lhomme,A. Dubow,L. Amazit,S. Traverset al. 33ème Congrès de la Société Fransaise d’Endocrinologie, 2016, Bordeaux, France Communication dans un congrès hal-05396073v1

Pré-publication, Document de travail (1)

Mitotane alters mitochondrial respiratory chain activity by inducing cytochrome c oxidase defect in human adrenocortical cells Ségolène Hescot,Abdelhamid Slama,Anne Lombes,Angelo Paci,Hervé Remyet al. 2014 Pré-publication, Document de travail inserm-00817795v1