Laurent Désaubry

Publications

Article dans une revue (92)

Development of capsaicin-derived prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction and mitophagy in cancer cells Amel Djehal,Claire Caron,Deborah Giordano,Valentina Pizza,Kimberley Farinet al. Communications Biology, 2026, ⟨10.1038/s42003-026-09573-3⟩ Article dans une revue hal-05493008v1
miR-124 orchestrates epicardial-mesenchymal transformation and paracrine cardiomyocyte maturation in epicardial-specific Tcf21-PKR1 knockout mice Himanshu Arora,Martina Vincenzi,Anais Audebrand,Amin Kremic,Carmine Gentileet al. STEM CELLS, 2026, 44 (3), pp.sxaf082. ⟨10.1093/stmcls/sxaf082⟩ Article dans une revue inserm-05561289v1
Second‐generation prokineticin PKR 1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity Anais Audebrand,Simone Brogi,Mustafa Tezeren,Andrea Tafi,Omer Ocaket al. British Journal of Pharmacology, 2026, Online ahead of print. ⟨10.1111/bph.70394⟩ Article dans une revue inserm-05561442v1
Methylated PIH1D1 as a Heart-Specific Biomarker for Anthracycline-Induced Cardiac Remodeling in Breast Cancer Patients Po-Yen Hsu,Wan-Hong Huang,Yi-Yun Lee,Robert Passier,Szu-Chin Liet al. JACC : Basic to Translational Science, 2026, 11 (4), pp.101510. ⟨10.1016/j.jacbts.2026.101510⟩ Article dans une revue inserm-05561282v1
Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination Emma R. Wilson,Gustavo Della‐flora Nunes,Shichen Shen,Seth Moore,Joseph Gawronet al. Glia, 2024, ⟨10.1002/glia.24610⟩ Article dans une revue hal-04736471v1
The prohibitin ligand IN44 decreases Porphyromonas gingivalis mediated inflammation Catherine Petit,Céline Stutz,Pierre-yves Gegout,Chloé Bloch,Hayriye Özceliket al. BMC Oral Health, 2024, 24, ⟨10.1186/s12903-024-05209-2⟩ Article dans une revue hal-04878792v1
Therapeutic Potential of Targeting Prokineticin Receptors in Diseases Martina Vincenzi,Amin Kremić,Appoline Jouve,Roberta Lattanzi,Rossella Mieleet al. Pharmacological Reviews, 2023, 75 (6), pp.1167-1199. ⟨10.1124/pharmrev.122.000801⟩ Article dans une revue hal-04270268v1
The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA Ann Kari Grindheim,Sudarshan S. Patil,Canan Nebigil,Laurent Désaubry,Anni Vedeler Frontiers in Cell and Developmental Biology, 2023, 11, ⟨10.3389/fcell.2023.1094941⟩ Article dans une revue hal-04268976v1
Targeting Prohibitins to Inhibit Melanoma Growth and Overcome Resistance to Targeted Therapies Ahmad Najem,Mohammad Krayem,Serena Sabbah,Matilde Pesetti,Fabrice Journeet al. Cells, 2023, 12 (14), pp.1855. ⟨10.3390/cells12141855⟩ Article dans une revue hal-04268975v1
Targeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo Junmei Liu,Ranran Zhang,Tong Su,Qianqian Zhou,Lin Gaoet al. Journal of experimental & clinical cancer research, 2023, 42 (1), ⟨10.1186/s13046-023-02695-0⟩ Article dans une revue hal-04268973v1
eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma Sara M. Steinmann,Anabel Sánchez-Martín,Elisabeth Tanzer,Antonio Cigliano,Giovanni M. Peset al. International Journal of Molecular Sciences, 2023, 24 (3), pp.2055. ⟨10.3390/ijms24032055⟩ Article dans une revue hal-04268974v1
Triazine-Based Small Molecules: A Potential New Class of Compounds in the Antifungal Toolbox Karen A. Conrad,Hyunjeong Kim,Mohammad Qasim,Amel Djehal,Aaron D. Herndayet al. Pathogens, 2023, 12 (1), pp.126. ⟨10.3390/pathogens12010126⟩ Article dans une revue hal-03942199v1
Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL Anne Largeot,Vanessa Klapp,Elodie Viry,Susanne Gonder,Iria Fernandez Botanaet al. Blood, 2023, 141 (26), ⟨10.1182/blood.2022017839⟩ Article dans une revue hal-04270267v1
Flavaglines: Their Discovery from Plants Used in Traditional Chinese Medicine, Synthesis, and Drug Development Against Cancer and Immune Disorders Dong Wang,Mustafa Ali Tezeren,Hussein Abou Hamdan,Peng Yu,Canan Nebigil-Désaubryet al. Current Chinese Chemistry, 2022, 2 (2), ⟨10.2174/2666001601666211126091737⟩ Article dans une revue hal-03806707v1
Non-classical ferroptosis inhibition by a small molecule targeting PHB2 Wei Yang,Bo Mu,Jing You,Chenyu Tian,Huachao Binet al. Nature Communications, 2022, 13 (1), ⟨10.1038/s41467-022-35294-2⟩ Article dans une revue hal-03942198v1
Development of fluorizoline analogues as prohibitin ligands that modulate C-RAF signaling, p21 expression and melanogenesis Nora Chouha,Hussein Abou Hamdan,Hajime Yurugi,Riku Yoshii,Hiromi Iiet al. European Journal of Medicinal Chemistry, 2022, 242, pp.114635. ⟨10.1016/j.ejmech.2022.114635⟩ Article dans une revue hal-03806694v1
Development of prohibitin ligands against osteoporosis Redouane Tabti,François Lamoureux,Céline Charrier,Benjamin Ory,Dominique Heymannet al. European Journal of Medicinal Chemistry, 2021, 210, pp.112961. ⟨10.1016/j.ejmech.2020.112961⟩ Article dans une revue hal-03420106v1
Updates on Anticancer Therapy-Mediated Vascular Toxicity and New Horizons in Therapeutic Strategies Po-Yen Hsu,Aynura Mammadova,Nadia Benkirane-Jessel,Laurent Désaubry,Canan Nebigil Frontiers in Cardiovascular Medicine, 2021, 8, ⟨10.3389/fcvm.2021.694711⟩ Article dans une revue hal-03373354v1
Prohibitin Inactivation in Adipocytes Results in Reduced Lipid Metabolism and Adaptive Thermogenesis Impairment Zhanguo Gao,Alexes C Daquinag,Cale Fussell,Amel Djehal,Laurent Désaubryet al. Diabetes, 2021, 70 (10), pp.2204-2212. ⟨10.2337/db21-0094⟩ Article dans une revue hal-03374098v1
Fluorizoline Blocks the Interaction between Prohibitin-2 and γ -Glutamylcyclotransferase and Induces p21 Waf1/Cip1 Expression in MCF7 Breast Cancer Cells Hiroko Takagi,Chiami Moyama,Keiko Taniguchi,Kota Ando,Ryohei Matsudaet al. Molecular Pharmacology, 2021, 101 (2), pp.78-86. ⟨10.1124/molpharm.121.000334⟩ Article dans une revue hal-03809849v1
Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells Tharcisio Citrangulo Tortelli,Rodrigo Esaki Tamura,Mara de Souza Junqueira,Janio da Silva Mororó,Silvina Odete Bustoset al. Aging, 2021, 13 (18), pp.21914-21940. ⟨10.18632/aging.203528⟩ Article dans une revue hal-03400765v1
The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/β-Catenin Signaling Dakota N Jackson,Kibrom M Alula,Yaritza Delgado-Deida,Redouane Tabti,Kevin Turneret al. Cancer Research, 2020, 80 (17), pp.3519-3529. ⟨10.1158/0008-5472.CAN-20-0216⟩ Article dans une revue hal-02996732v1
Prohibitin, STAT3 and SH2D4A physically and functionally interact in tumor cell mitochondria Carolin Ploeger,Thorben Huth,Raisatun Nisa Sugiyanto,Stefan Pusch,Benjamin Goeppertet al. Cell Death and Disease, 2020, 11 (11), ⟨10.1038/s41419-020-03220-3⟩ Article dans une revue hal-03032751v1
Discovery of 3,3′-pyrrolidinyl-spirooxindoles as cardioprotectant prohibitin ligands Sabria Elderwish,Anaïs Audebrand,Canan G Nebigil,Laurent Désaubry European Journal of Medicinal Chemistry, 2020, 186, pp.111859. ⟨10.1016/j.ejmech.2019.111859⟩ Article dans une revue hal-02996582v1
Recent Advances in the Synthesis of C2‐Functionalized Pyridines and Quinolines Using N ‐Oxide Chemistry Dong Wang,Laurent Désaubry,Gaoyu Li,Mindong Huang,Shixin Zheng Advanced Synthesis and Catalysis, In press, ⟨10.1002/adsc.202000910⟩ Article dans une revue hal-03028714v1
A subset of flavaglines inhibits KRAS nanoclustering and activation Hajime Yurugi,Yinyin Zhuang,Farid A Siddiqui,Hong Liang,Sebastian Rosigkeitet al. Journal of Cell Science, 2020, 133 (12), pp.jcs244111. ⟨10.1242/jcs.244111⟩ Article dans une revue hal-02996708v1
Prokineticin signaling in heart-brain developmental axis: Therapeutic options for heart and brain injuries Laurent Désaubry,Anumantha G Kanthasamy,Canan G Nebigil Pharmacological Research, 2020, 160, pp.105190. ⟨10.1016/j.phrs.2020.105190⟩ Article dans une revue hal-03014835v1
SFPH proteins as therapeutic targets for a myriad of diseases Dong Wang,Redouane Tabti,Sabria Elderwish,Amel Djehal,Nora Chouhaet al. Bioorganic and Medicinal Chemistry Letters, 2020, 30 (22), pp.127600. ⟨10.1016/j.bmcl.2020.127600⟩ Article dans une revue hal-03092105v1
Targeting GPCRs Against Cardiotoxicity Induced by Anticancer Treatments Anais Audebrand,Laurent Désaubry,Canan G Nebigil Frontiers in Cardiovascular Medicine, 2020, 6, pp.194. ⟨10.3389/fcvm.2019.00194⟩ Article dans une revue hal-02996608v1
Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses Canan G Nebigil,Christiane Moog,Stéphan Vagner,Nadia Benkirane-Jessel,Duncan R Smithet al. European Journal of Medicinal Chemistry, 2020, 203, pp.112653. ⟨10.1016/j.ejmech.2020.112653⟩ Article dans une revue hal-02996744v1
Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes Ezeddine Harmouch,Joseph Seitlinger,Hassan Chaddad,Geneviève Ubeaud-Sequier,Jochen Barthset al. Scientific Reports, 2020, 10 (1), pp.13750. ⟨10.1038/s41598-020-70820-6⟩ Article dans une revue hal-03018022v1
One-Pot Selective Saturation and Functionalization of Heteroaromatics Leading to Dihydropyridines and Dihydroquinolines Dong Wang,Yuanyang Jiang,Linru Dong,Gaoyu Li,Baoying Sunet al. Journal of Organic Chemistry, 2020, 85 (7), pp.5027 - 5037. ⟨10.1021/acs.joc.0c00314⟩ Article dans une revue hal-02996680v1
The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis Xin Jin,Jianling Xie,Michael Zabolocki,Xuemin Wang,Tao Jianget al. Journal of Biological Chemistry, 2020, 295 (29), pp.9855 - 9867. ⟨10.1074/jbc.ra120.012979⟩ Article dans une revue hal-03413807v1
Unexpected Inversion of Configuration During the Carbamoylation of 1-Azaflavaglines Hussein Abou-Hamdan,Laurent Désaubry SYNLETT, 2020, 31 (20), pp.2023-2026. ⟨10.1055/s-0040-1707277⟩ Article dans une revue hal-03373324v1
Recent advances in the synthesis of 2,3-dihydropyrroles Dong Wang,Yu Fan,Peng Yu,Laurent Désaubry Chemical Communications, 2020, 56 (42), pp.5584-5592. ⟨10.1039/D0CC02096F⟩ Article dans une revue hal-02996692v1
Accessing 1,8‐Naphthyridones by Metal‐Free Regioselective Amination of Pyridine N ‐oxides/Acid‐Mediated Cyclization Lianbo Zhao,Lei Hao,Yupeng Fu,Yan Cheng,Guojun Panet al. Advanced Synthesis and Catalysis, 2020, 362 (18), pp.3841-3845. ⟨10.1002/adsc.202000769⟩ Article dans une revue hal-02996754v1
Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects Hafidha Bentayeb,Marine Aitamer,Barbara Petit,Lydie Dubanet,Sabria Elderwishet al. Journal of experimental & clinical cancer research, 2019, 38 (1), ⟨10.1186/s13046-019-1440-4⟩ Article dans une revue hal-02361081v1
Stereoselective Four-Component Synthesis of Functionalized 2,3-Dihydro-4-Nitropyrroles Dong Wang,Xinyue Ma,Linru Dong,Hairong Feng,Peng Yuet al. Frontiers in Chemistry, 2019, 7, ⟨10.3389/fchem.2019.00810⟩ Article dans une revue hal-02996593v1
An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells Shensi Shen,Sara Faouzi,Amandine Bastide,Sylvain Martineau,Hélène Malka-Mahieuet al. Nature Communications, 2019, 10 (1), pp.5713. ⟨10.1038/s41467-019-13360-6⟩ Article dans une revue hal-02418638v1
The synthetic flavagline FL3 spares normal human skin cells from its cytotoxic effect via an activation of Bad Fathi Emhemmed,Sarah Ali Azouaou,Sarah Hassan,Ray Lefevbre,Laurent Desaubryet al. Toxicology in Vitro, 2019, 60, pp.27-35. ⟨10.1016/j.tiv.2019.04.025⟩ Article dans une revue hal-03033544v1
Correction to: The mTOR-S6 kinase pathway promotes stress granule assembly Aristeidis Sfakianos,Laura Mellor,Yoke Fei Pang,Paraskevi Kritsiligkou,Hope Needset al. Cell Death and Differentiation, 2019, ⟨10.1038/s41418-019-0438-y⟩ Article dans une revue hal-02361047v1
The synthetic flavagline FL3 suppresses intestinal tumorigenesis in APC(Mini+) mice Dn Jackson,Hussein Abou-Hamdan,Bn Cook,Laurent Désaubry,Rf Souzaet al. FASEB Journal, 2019, 33, ⟨10.1096/fasebj.2019.33.1_supplement.761.2⟩ Article dans une revue hal-05255907v1
The role of GPCR signaling in cardiac Epithelial to Mesenchymal Transformation (EMT) Canan G Nebigil,Laurent Désaubry Trends in Cardiovascular Medicine, 2019, 29 (4), pp.200-204. ⟨10.1016/j.tcm.2018.08.007⟩ Article dans une revue hal-03014893v1
Prokineticin Receptor-1 Signaling Inhibits Dose- and Time-Dependent Anthracycline-Induced Cardiovascular Toxicity Via Myocardial and Vascular Protection Adeline Gasser,Yue-Wen Chen,Anais Audebrand,Ayhan Daglayan,Marine Charavinet al. JACC: CardioOncology, 2019, 1 (1), pp.84-102. ⟨10.1016/j.jaccao.2019.06.003⟩ Article dans une revue hal-03092065v1
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis Chaojun Yan,Longlong Gong,Li Chen,Meng Xu,Hussein Abou-Hamdanet al. Autophagy, 2019, pp.1-16. ⟨10.1080/15548627.2019.1628520⟩ Article dans une revue hal-02361056v1
Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer Marine F Garrido,Nicolas J.-P. Martin,Matthieu Bertrand,Catherine Gaudin,Frédéric Commoet al. Clinical Cancer Research, 2019, 25 (2), pp.710-723. ⟨10.1158/1078-0432.CCR-18-0704⟩ Article dans une revue hal-03210950v1
Catalyst-free three-component synthesis of highly functionalized 2,3-dihydropyrroles Dong Wang,Linna Li,Hairong Feng,Hua Sun,Fabrice Almeida-Velosoet al. Green Chemistry, 2018, 20 (12), pp.2775-2780. ⟨10.1039/C8GC00987B⟩ Article dans une revue hal-01829592v1
Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway Gangjun Yuan,Xin Chen,Zhuowei Liu,Wensu Wei,Qinghai Shuet al. Journal of experimental & clinical cancer research, 2018, 37 (1), ⟨10.1186/s13046-018-0695-5⟩ Article dans une revue hal-02361608v1
Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells Amel Djehal,Mohammad Krayem,Ahmad Najem,Hassan Hammoud,Thierry Cresteilet al. European Journal of Medicinal Chemistry, 2018, 155, pp.880-888. ⟨10.1016/j.ejmech.2018.06.052⟩ Article dans une revue hal-02361593v1
The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model Marina Wierz,Sandrine Pierson,Nora Chouha,Laurent Désaubry,Jean-Hugues Françoiset al. Haematologica, 2018, 103 (4), pp.e154-e157. ⟨10.3324/haematol.2017.175349⟩ Article dans une revue hal-02361624v1
The mTOR-S6 kinase pathway promotes stress granule assembly Aristeidis Sfakianos,Laura Mellor,Yoke Fei Pang,Paraskevi Kritsiligkou,Hope Needset al. Cell Death and Differentiation, 2018, 25 (10), pp.1766-1780. ⟨10.1038/s41418-018-0076-9⟩ Article dans une revue hal-02361603v1
Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes Matthew Neal,Jie Luo,Dilshan Harischandra,Richard Gordon,Souvarish Sarkaret al. Glia, 2018, 66 (10), pp.2137-2157. ⟨10.1002/glia.23467⟩ Article dans une revue hal-02361086v1
Updates in Anthracycline-Mediated Cardiotoxicity Canan G Nebigil,Laurent Désaubry Frontiers in Pharmacology, 2018, 9, pp.1262. ⟨10.3389/fphar.2018.01262⟩ Article dans une revue hal-01935306v1
Targeting a Gpcr, Prokineticin Receptor-1, Protects Heart Against Doxorubicin-Mediated Cardiotoxicity Canan G Nebigil,Adeline Gasser,Marine Charavin,Brigitte Escoubet,Anais Audebrandet al. Circulation, 2018, 138 Article dans une revue hal-04835044v1
Emergence of cardio-oncology Canan G Nebigil,L. Desaubry Annales Pharmaceutiques Françaises, 2018, 76 (6), pp.504-506. ⟨10.1016/j.pharma.2018.06.003⟩ Article dans une revue hal-02361588v1
The synthetic flavagline FL3 protects against colitis-associated cancer via inhibition of wnt/beta-catenin signaling Dn Jackson,J Han,Hussein Abou Hamdan,Laurent Désaubry,Xf Huoet al. Gastroenterology, 2018, 154 (6) Article dans une revue hal-04835052v1
Translational control of tumor immune escape via the eIF4F–STAT1–PD-L1 axis in melanoma Michael Cerezo,Ramdane Guemiri,Sabine Druillennec,Isabelle Girault,Hélène Malka-Mahieuet al. Nature Medicine, 2018, 24 (12), pp.1877-1886. ⟨10.1038/s41591-018-0217-1⟩ Article dans une revue hal-02361063v1
CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts Ricardos Tabet,Laure Schaeffer,Fernande Freyermuth,Melanie Jambeau,Michael Workmanet al. Nature Communications, 2018, 9 (1), pp.152. ⟨10.1038/s41467-017-02643-5⟩ Article dans une revue hal-02361614v1
Scalable 9-Step Synthesis of the Splicing Modulator NVS-SM2 Hussein Abou-Hamdan,Laurent Désaubry Journal of Organic Chemistry, 2018, 83 (5), pp.2954-2958. ⟨10.1021/acs.joc.7b03009⟩ Article dans une revue hal-01830554v1
Pro-differentiating effects of a synthetic flavagline on human teratocarcinomal cancer stem-like cells Fathi Emhemmed,Sarah Ali Azouaou,Qian Zhao,Aline Appert-Collin,Amar Bennasrouneet al. Cell Biology and Toxicology, 2017, 33 (3), pp.295-306. ⟨10.1007/s10565-016-9375-4⟩ Article dans une revue hal-02106909v1
Molecular Pathways: The eIF4F Translation Initiation Complex—New Opportunities for Cancer Treatment Hélène Malka-Mahieu,Michelle Newman,Laurent Désaubry,Caroline Robert,Stéphan Vagner Clinical Cancer Research, 2017, 23 (1), pp.21-25. ⟨10.1158/1078-0432.CCR-14-2362⟩ Article dans une revue hal-03533702v1
Abstract IA29: Role of eIF4F in anticancer drug resistance Galina Boldina,Maricarmen Vallejos,Delphine Allard,Isabelle Girault,Hélène Malka-Mahieuet al. Cancer Research, 2017, 77 (6_Supplement), pp.IA29-IA29. ⟨10.1158/1538-7445.Transcontrol16-IA29⟩ Article dans une revue hal-04833132v1
FL3, A LIGAND OF THE SCAFFOLD PROTEIN PROHIBITIN, INHIBITS THE PROGRESSION TO COLORECTAL CANCER Jie Han,Qian Zhao,Christine C. Basmadjian,Laurent Desaubry,Arianne L. Theiss Gastroenterology, 2017, 152 (5), ⟨10.1016/S0016-5085(17)30411-0⟩ Article dans une revue hal-05258889v1
Erratum: Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours H Yurugi,F Marini,C Weber,K David,Qian Zhaoet al. Oncogene, 2017, 36 (42), pp.5914-5914. ⟨10.1038/onc.2017.307⟩ Article dans une revue hal-04873321v1
Synthesis of hydroxybenzofurans by condensation of quinones with benzoylacetone: revised structure of the adducts Hassan Hammoud,Qian Zhao,Laurent Désaubry Tetrahedron Letters, 2016, 57 (36), pp.4044-4045. ⟨10.1016/j.tetlet.2016.07.074⟩ Article dans une revue istex hal-03536456v1
Bioisosteric modification of flavaglines Qian Zhao,Annemilaï Tijeras-Raballand,Armand de Gramont,Eric Raymond,Laurent Désaubry Tetrahedron Letters, 2016, 57 (26), pp.2943-2944. ⟨10.1016/j.tetlet.2016.05.089⟩ Article dans une revue istex hal-03533709v1
Flavaglines Ameliorate Experimental Colitis and Protect Against Intestinal Epithelial Cell Apoptosis and Mitochondrial Dysfunction: Jie Han,Qian Zhao,Christine Basmadjian,Laurent Désaubry,Arianne L. Theiss Inflammatory Bowel Diseases, 2016, 22 (1), pp.55-67. ⟨10.1097/MIB.0000000000000592⟩ Article dans une revue hal-03536459v1
Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines Hélène Malka-Mahieu,Isabelle Girault,Margot Rubington,Melissa Leriche,Caroline Welschet al. Cell Cycle, 2016, 15 (18), pp.2405-2409. ⟨10.1080/15384101.2016.1208862⟩ Article dans une revue hal-03536458v1
A General and Efficient Synthesis of 2-Pyridones, 2-Quinolinones, and 1-Isoquinolinones from Azine N -Oxides Dong Wang,Junjie Zhao,Yuxi Wang,Jianyong Hu,Linna Liet al. Asian Journal of Organic Chemistry, 2016, 5 (12), pp.1442-1446. ⟨10.1002/ajoc.201600430⟩ Article dans une revue istex hal-03536473v1
Recent Advances in the Synthesis of Flavaglines, a Family of Potent Bioactive Natural Compounds Originating from Traditional Chinese Medicine Qian Zhao,Hussein Abou Hamdan,Laurent Désaubry European Journal of Organic Chemistry, 2016, 2016 (36), pp.5908-5916. ⟨10.1002/ejoc.201600437⟩ Article dans une revue istex hal-03533707v1
FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity Rehana Qureshi,Onur Yildirim,Adeline Gasser,Christine Basmadjian,Qian Zhaoet al. PLoS ONE, 2015, 10 (11), pp.e0141826. ⟨10.1371/journal.pone.0141826⟩ Article dans une revue hal-02391039v1
Discovery and Cardioprotective Effects of the First Non-Peptide Agonists of the G Protein-Coupled Prokineticin Receptor-1 Adeline Gasser,Simone Brogi,Kyoji Urayama,Toshishide Nishi,Hitoshi Kuroseet al. PLoS ONE, 2015, 10 (4), pp.e0121027. ⟨10.1371/journal.pone.0121027⟩ Article dans une revue hal-02391041v1
Cancer wars: natural products strike back Christine Basmadjian,Qian Zhao,Embarek Bentouhami,Amel Djehal,Canan G Nebigilet al. Frontiers in Chemistry, 2014, 2, ⟨10.3389/fchem.2014.00020⟩ Article dans une revue hal-02391047v1
Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway Fathi Emhemmed,Sarah Ali Azouaou,Frédéric Thuaud,Valerie Schini-Kerth,Laurent Désaubryet al. Biochemical Pharmacology, 2014, 89 (2), pp.185-196. ⟨10.1016/j.bcp.2014.02.020⟩ Article dans une revue istex hal-02106955v1
Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway. F. Emhemmed,S. Ali Azouaou,F. Thuand,V. Schini-Kerth,L. Desaubryet al. Biochemical Pharmacology, 2014, 89, pp.185-196 Article dans une revue hal-01065063v1
N -[3a-(4-Bromophenyl)-8b-hydroxy-6,8-dimethoxy-3-phenyl-2,3,3a,8b-tetrahydro-1 H -cyclopenta[ b ]benzofuran-1-yl]formamide monohydrate Emmanuel Aubert,Frédéric Thuaud,Nigel Ribeiro,Laurent Désaubry,Enrique Espinosa Acta Crystallographica Section E : Structure Reports Online [2001-2014], 2013, 69 (1), pp.o52 - o53. ⟨10.1107/S1600536812049641⟩ Article dans une revue hal-01521958v1
Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential Frédéric Thuaud,Nigel Ribeiro,Canan G Nebigil,Laurent Désaubry Chemistry and Biology, 2013, 20 (3), pp.316-331. ⟨10.1016/j.chembiol.2013.02.006⟩ Article dans une revue hal-02391060v1
Cytochromes P450 CYP94C1 and CYP94B3 catalyze two successive oxidation steps of the plant hormone jasmonoyl-isoleucine for catabolic turnover T. Heitz,E. Widemann,R. Lugan,L. Miesch,P. Ullmannet al. Journal of Biological Chemistry, 2012, 287 (9), pp.6296-6306. ⟨10.1074/jbc.M111.316364⟩ Article dans une revue hal-00680337v1
Recent advances in the biology and chemistry of the flavaglines Nigel Ribeiro,Frédéric Thuaud,Canan G Nebigil,Laurent Désaubry Bioorganic and Medicinal Chemistry Letters, 2012, 20 (6), pp.1857-1864. ⟨10.1016/j.bmc.2011.10.048⟩ Article dans une revue istex hal-02391066v1
Flavaglines as potent anticancer and cytoprotective agents. Nigel Ribeiro,Frédéric Thuaud,Yohann Bernard,Christian Gaiddon,Thierry Cresteilet al. Journal of Medicinal Chemistry, 2012, 55 (22), pp.10064-73. ⟨10.1021/jm301201z⟩ Article dans une revue hal-00765387v1
Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27 Yohann Bernard,Nigel Ribeiro,Frédéric Thuaud,Gülen Türkeri,Ronan Dirret al. PLoS ONE, 2011, 6 (10), pp.e25302. ⟨10.1371/journal.pone.0025302⟩ Article dans une revue hal-02391070v1
Novel Flavaglines Displaying Improved Cytotoxicity. Frédéric Thuaud,Nigel Ribeiro,Christian Gaiddon,Thierry Cresteil,Laurent Désaubry Journal of Medicinal Chemistry, 2010, 54 (1), pp.411-415. ⟨10.1021/jm101318b⟩ Article dans une revue hal-00572526v1
Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12 Frédéric Thuaud,Yohann Bernard,Gülen Türkeri,Ronan Dirr,Geneviève Aubertet al. Journal of Medicinal Chemistry, 2009, 52 (16), pp.5176-5187. ⟨10.1021/jm900365v⟩ Article dans une revue hal-02391094v1
Synthesis and biological evaluation of PEG-tirofiban conjugates Laurent Désaubry,Stéphanie Riché,Patricia Laeuffer,Jean-Pierre Cazenave Bioorganic and Medicinal Chemistry Letters, 2008, 18 (6), pp.2028-2031. ⟨10.1016/j.bmcl.2008.01.118⟩ Article dans une revue istex hal-04724806v1
Synthesis of 3-O-methylviridicatin analogues with improved anti-TNF-α properties Nigel Ribeiro,Helena Tabaka,Jean Peluso,Ludivine Fetzer,Canan G Nebigilet al. Bioorganic and Medicinal Chemistry Letters, 2007, 17 (20), pp.5523-5524. ⟨10.1016/j.bmcl.2007.08.036⟩ Article dans une revue istex hal-02391115v1
Reinforcing effect of bi- and tri-cyclopolyprenols on ‘primitive' membranes made of polyprenyl phosphates. N. Ribeiro,S. Streiff,D. Heissler,M. Elhabiri,A.M. Albrecht-Garyet al. Tetrahedron, 2007, 63, pp.3395-3407 Article dans une revue hal-00139371v1
Future alchemy: account of the ESYOP experiment Philippe Compain,Valérie Desvergnes,Cyril Ollivier,Frédéric Robert,Franck Suzenetet al. Comptes Rendus. Chimie, 2006, 9, pp.127-140. ⟨10.1016/j.crci.2005.09.004⟩ Article dans une revue istex hal-00158010v1
Looking forward : a glance into the future of organic chemistry Philippe Compain,Valérie Desvergnes,Cyril Ollivier,Frédéric Robert,Franck Suzenetet al. New Journal of Chemistry, 2006, 30 (6), pp.823-831. ⟨10.1039/B601837H⟩ Article dans une revue istex hal-00158370v1
Palladium catelysed arylation of 6,8-dimethoxybenzofuranone. A. Sani Souna Sido,L. Boulenger,L. Desaubry Tetrahedron Letters, 2005, 46, pp.8017-8018 Article dans une revue hal-00129976v1
Concise synthesis and voltammetric studies of dielsiquinone, a cytotoxic azaanthraquinone. A. Brisach-Wittmeyer,A. Sani Souna Sido,P. Guilini,L. Desaubry Bioorganic and Medicinal Chemistry Letters, 2005, 15, pp.3609-3610 Article dans une revue hal-00129824v1
Unexpected cleavage of tetrahydrofuran by catalytic reductive lithiation S. Streiff,N. Ribeiro,L. Desaubry Chemical Communications, 2004, pp.346-347 Article dans une revue hal-00167410v1
Synthesis of allylsilanes by reductive lithiation of thioethers. S. Streiff,N. Ribeiro,L. Desaubry Journal of Organic Chemistry, 2004, 69, pp.7592-7598 Article dans une revue hal-00167414v1

Pré-publication, Document de travail (1)

Development of capsaicin derivatives as prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction in cancer cells Amel Djehal,Claire Caron,Valentina Pizza,Kimberley Farin,Giulia Bertolinet al. 2024 Pré-publication, Document de travail hal-04634826v1

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Targeting Translation By Disrupting The Newly Identified Prohibitin-eif4f Complex As A Novel Therapeutic Strategy In Chronic Lymphocytic Leukemia A. Largeot,V. Klapp,S. Gonder,E. Viry,M. Szpakowskaet al. 27th Congress of the European Hematology Association, Jun 2022, Vienne & Online, Italy. 6, pp.518-519, 2022, ⟨10.1097/01.HS9.0000845364.22279.91⟩ Poster de conférence hal-05453624v1

Communication dans un congrès (1)

Cardioprotective effect of non-peptidic pkr1 agonist against anthracycline-cardiotoxicity Adeline Gasser,Marine Charavin,Brigitte Escoubet,Nadia Messaddeq,Laurent Désaubryet al. Heart Failure 2017 and the 4th World Congress on Acute Heart Failure, Paris, France, 29 April – 2 May 2017, May 2017, Paris, France. pp.511-511 Communication dans un congrès hal-04837835v1

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Bioactive Flavaglines: Synthesis and Pharmacology Christine Basmadjian,Qian Zhao,Armand De Gramont,Maria Serova,Sandrine Faivreet al. Goutam Brahmachari. Bioactive Natural Products: Chemistry and Biology, Wiley, 2014, 9783527684403. ⟨10.1002/9783527684403.ch7⟩ Chapitre d'ouvrage hal-04819204v1

Brevet (1)

Prokineticin 1 receptor agonists and their uses Laurent Desaubry,Gunsel Canan Desaubry,Mounia Boulberdaa,Michel Kindo,Andrea Tafiet al. France, Patent n° : WO2012/084999. 2012 Brevet hal-04878270v1