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Laurent Maveyraud

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The conserved yeast protein Knr4 involved in cell wall integrity is a multi-domain intrinsically disordered protein

Manon Batista , Ellen I.M. Donker , Cécile Bon , Myriam Guillien , Adriana Caisso
Journal of Molecular Biology, 2023, 435 (10), pp.168048. ⟨10.1016/j.jmb.2023.168048⟩
Journal articles hal-03874437v2
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Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA

Mélina Chebaiki , Evelyne Delfourne , Rasoul Tamhaev , Saïda Danoun , Frédéric Rodriguez
European Journal of Medicinal Chemistry, 2023, 259, pp.115646. ⟨10.1016/j.ejmech.2023.115646⟩
Journal articles hal-04244940v1
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Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis

Nguyen-Hung Le , Patricia Constant , Samuel Tranier , Virginie Nahoum , Valérie Guillet
Bioorganic and Medicinal Chemistry Letters, 2022, 71, pp.116938. ⟨10.1016/j.bmc.2022.116938⟩
Journal articles hal-03758907v1
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Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from Mycobacterium tuberculosis

Romain Galy , Stéphanie Ballereau , Yves Génisson , Lionel Mourey , Jean-Christophe Plaquevent
Pharmaceuticals, 2021, 14 (12), pp.1282. ⟨10.3390/ph14121282⟩
Journal articles hal-03683937v1
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Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds

Coralie Carivenc , Laurent Maveyraud , Claire Blanger , Stéphanie Ballereau , Coralie Roy-Camille
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-97197-4⟩
Journal articles hal-03345048v1
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Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases

Anna D Grabowska , Yoann Brison , Laurent Maveyraud , Sabine Gavalda , Alexandre Faille
ACS Chemical Biology, 2020, 15 (12), pp.3206 - 3216. ⟨10.1021/acschembio.0c00772⟩
Journal articles hal-03752170v2
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Protein X-ray Crystallography and Drug Discovery

Laurent Maveyraud , Lionel Mourey
Molecules, 2020, 25 (5), pp.1030. ⟨10.3390/molecules25051030⟩
Journal articles hal-02950589v1
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Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components

Luis F Garcia-Alles , Katharina Root , Laurent Maveyraud , Nathalie Aubry , Eric Lesniewska
PLoS ONE, 2019, 14 (10), pp.e0223877. ⟨10.1371/journal.pone.0223877⟩
Journal articles hal-03841381v1
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Structural insights into chaperone addiction of toxin-antitoxin systems

Valerie Guillet , Patricia Bordes , Cécile Bon , Julien Marcoux , Virginie Gervais
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-08747-4⟩
Journal articles hal-02335509v1

An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors

Aurélien Chollet , Laurent Maveyraud , Christian Lherbet , Vania Bernardes-Génisson
European Journal of Medicinal Chemistry, 2018, 146, pp.318-343. ⟨10.1016/j.ejmech.2018.01.047⟩
Journal articles hal-01952876v1
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Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases

Alexandre Faille , Sabine Gavalda , Nawel Slama , Christian Lherbet , Laurent Maveyraud
Journal of Molecular Biology, 2017, 429 (47), pp.1554 - 1569. ⟨10.1016/j.jmb.2017.03.026⟩
Journal articles hal-03002100v1
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Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria

Valérie Guillet , Ségolène Galandrin , Laurent Maveyraud , Simon Ladevèze , Vincent Mariaule
Journal of Biological Chemistry, 2016, 291 (15), pp.7973-7989. ⟨10.1074/jbc.M115.712612⟩
Journal articles hal-03002148v1
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Crystallographic studies of the structured core domain of Knr4 fromSaccharomyces cerevisiae

Sylviane Julien , Patrick Tondl , Fabien Durand , Adilia Dagkessamanskaia , Herman van Tilbeurgh
Acta crystallographica Section F : Structural biology communications [2014-..], 2015, 71 (9), pp.1120 - 1124. ⟨10.1107/s2053230x15012522⟩
Journal articles hal-03002962v1
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Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach

Aurélien Chollet , Lionel Mourey , Christian Lherbet , Alexandra Delbot , Sylviane Julien
Journal of Structural Biology, 2015, 190, pp.328 - 337. ⟨10.1016/j.jsb.2015.04.008⟩
Journal articles hal-03002973v1
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Residues Essential for Panton-Valentine Leukocidin S Component Binding to Its Cell Receptor Suggest Both Plasticity and Adaptability in Its Interaction Surface

Benoit-Joseph Laventie , Frédéric Guerin , Lionel Mourey , Mira y Tawk , Emmanuel Jover
PLoS ONE, 2014, 9 (3), pp.e92094. ⟨10.1371/journal.pone.0092094⟩
Journal articles hal-03002978v1

Crystallization and preliminary crystallographic studies of both components of the staphylococcal LukE–LukD leukotoxin

Romain Galy , Fabien Bergeret , Daniel Keller , Lionel Mourey , Gilles Prévost
Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2012, 68, pp.663 - 667. ⟨10.1107/s1744309112014662⟩
Journal articles hal-03003049v1
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Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes

Luis Garcia-Alles , Gaelle Giacometti , Cees Versluis , Laurent Maveyraud , Diane de Paepe
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (32), pp.13230 - 13235. ⟨10.1073/pnas.1105627108⟩
Journal articles hal-03003375v1
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Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids

L F Garcia-Alles , A Collmann , C Versluis , B Lindner , J Guiard
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (43), pp.17755 - 17760. ⟨10.1073/pnas.1110118108⟩
Journal articles hal-03003377v1
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A covalent S-F heterodimer of leucotoxin reveals molecular plasticity of β-barrel pore-forming toxins

Pierre Roblin , Valérie Guillet , Olivier R. Joubert , Daniel Keller , Monique Erard
Proteins - Structure, Function and Bioinformatics, 2008, 71, pp.485 - 496. ⟨10.1002/prot.21900⟩
Journal articles hal-03003397v1
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Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra

Laurent Maveyraud , Hideaki Niwa , Valérie Guillet , Dmitri I Svergun , Peter V Konarev
Proteins - Structure, Function and Bioinformatics, 2008, 75, pp.89 - 103. ⟨10.1002/prot.22222⟩
Journal articles hal-03003386v1

Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b

Luis Garcia-Alles , Kees Versluis , Laurent Maveyraud , Ana Tesouro Vallina , Sebastiano Sansano
EMBO Journal, 2006, 25 (15), pp.3684 - 3692. ⟨10.1038/sj.emboj.7601244⟩
Journal articles hal-03003440v1

6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of .BETA.-Lactamases.

Dasantila Golemi , Laurent Maveyraud , Akihiro Ishiwata , Samuel Tramer , Kazuyuki Miyashita
Journal of Antibiotics, 2000, 53 (10), pp.1022-1027. ⟨10.7164/antibiotics.53.1022⟩
Journal articles hal-03004369v1
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The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins

Jean-Denis Pedelacq , Laurent Maveyraud , Gilles Prévost , Lamine Baba-Moussa , Ana González
Structure, 1999, 7 (3), pp.277-287. ⟨10.1016/s0969-2126(99)80038-0⟩
Journal articles hal-03004378v1

Crystal structure of Escherichia coli methionyl-tRNA synthetase highlights species-specific features.

Yves Mechulam , Emmanuelle Schmitt , Laurent Maveyraud , Charles Zelwer , Osamu Nureki
Journal of Molecular Biology, 1999, 294 (5), pp.1287-1297. ⟨10.1006/jmbi.1999.3339⟩
Journal articles hal-00841066v1
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X-ray Analysis of the NMC-A β-Lactamase at 1.64-Å Resolution, a Class A Carbapenemase with Broad Substrate Specificity

Peter Swarén , Laurent Maveyraud , Xavier Raquet , Stéphanie Cabantous , Colette Duez
Journal of Biological Chemistry, 1998, 273 (41), pp.26714-26721. ⟨10.1074/jbc.273.41.26714⟩
Journal articles hal-03004553v1
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Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A β-Lactamases from the Antibiotic-Resistant Bacteria

Laurent Maveyraud , Lionel Mourey , Lakshmi P Kotra , Jean-Denis Pedelacq , Valérie Guillet
Journal of the American Chemical Society, 1998, 120 (38), pp.9748-9752. ⟨10.1021/ja9818001⟩
Journal articles hal-03004592v1
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Structural Basis of Extended Spectrum TEM ␤-Lactamases CRYSTALLOGRAPHIC, KINETIC, AND MASS SPECTROMETRIC INVESTIGATIONS OF ENZYME MUTANTS*

Laurent Maveyraud , Isabelle Saves , Odile Burlet-Schiltz , Peter Swarén , Jean-Michel Masson
Journal of Biological Chemistry, 1996, 271 (18), pp.10482-10489. ⟨10.1074/jbc.271.18.10482⟩
Journal articles hal-03004742v1
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Electrostatic analysis of TEM1 -lactamase: effect of substrate binding, steep potential gradients and consequences of site-directed mutations

Peter Swarén , Laurent Maveyraud , Valérie Guillet , Jean-Michel Masson , Lionel Mourey
Structure, 1995, 3 (6), pp.603-613. ⟨10.1016/s0969-2126(01)00194-0⟩
Journal articles hal-03004753v1

Conception, synthesis and evaluation of new inhibitors of Mycobacterium abscessus InhA

Adèle Brison , Rasoul Tamhaev , Joelle Azema , Laurent Maveyraud , Lionel Mourey
Journée scientifique toulousaine de Chimie-Biologie-Santé (JCBS), Apr 2023, Toulouse, France
Conference poster hal-04199164v1

In situ click chemistry for the formation of novel InhA inhibitors of Mycobacterium tuberculosis

Melina Chebaiki , Evelyne Delfourne , Saïda Danoun , Isabelle Fabing , Laurent Maveyraud
Journée de Chimie du Grand Sud-Ouest, Jul 2022, Toulouse, France
Conference poster hal-03812172v1

Dynamic Combinatorial X-Ray crystallography : Toward new inhibitors of InhA, an essential enzyme from Mycobacterium tuberculosis”

R. Tamhaev , Laurent Maveyraud , Lionel Mourey , Christian Lherbet
9ème Ecole RéNaFoBiS (Réseau National de Formation en Biologie Structurale Intégrative), Jun 2022, OLERON, France
Conference poster hal-03812179v1

Dynamic Combinatorial X-ray crystallography: toward new inhibitors of InhA, an essential enzyme from Mycobacterium tuberculosis

Rasoul Tamhaev , Laurent Maveyraud , Lionel Mourey , Christian Lherbet
European Crystallography Meeting, 33rd edition, Aug 2022, Versailles, France
Conference poster hal-04192428v1

Vers de nouveaux inhibiteurs d'InhA découverts par cristallographie combinatoire dynamique aux rayons X

R. Tamhaev , Laurent Maveyraud , Lionel Mourey , Christian Lherbet
2ème Journées Scientifique du GDR ChemBio– 34ieme Journée Chimie - biologie - Santé, Jun 2022, Toulouse, France
Conference poster hal-03685340v1

The integrated screening platform of Toulouse (PICT) : A tool for accelerated molecular discovery

Isabelle Fabing , Michel Baltas , Stéphanie Ballereau , Tessa Castellan , Yves Génisson
10th International Chemistry Conference Toulouse-Kiev (ICTK-10), Jun 2019, Toulouse, France
Conference poster hal-02335559v1

The integrated screening platform of Toulouse (PICT) : A tool for accelerated molecular discovery

Brigitte Guidetti , Isabelle Fabing , Michel Baltas , Stéphanie Ballereau , Tessa Castellan
33e journée Chimie-Biologie-Santé, Apr 2019, Toulouse, France
Conference poster hal-02338497v1

The integrated screening platform of Toulouse (PICT) : A tool for accelerated molecular discovery

Isabelle Fabing , Michel Baltas , Stéphanie Ballereau , Yves Génisson , Brigitte Guidetti
Congress SFC 2018 Chemistry and Life Symposium, Jun 2018, Montpellier, France
Conference poster hal-02337455v1
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A Structural Approach to Discover an Achilles'heel of fungi : the case of Knr4/Smi1

Hélène Martin-Yken , Didier Zerbib , Sylviane Julien , Lionel Mourey , Laurent Maveyraud
Fungal Cell Wall Meeting, Oct 2015, Paris, France
Conference poster hal-02951422v1

Molecular Dynamics as a Tool for Virtual Ligand Screening

Grégory Menchon , Laurent Maveyraud , Georges Czaplicki
Computational Drug Discovery and Design, 2714, pp.33-83, 2024, Methods in Molecular Biology, ⟨10.1007/978-1-0716-3441-7_3⟩
Book sections hal-04258325v1