Laurent Maveyraud

Publications

Article dans une revue (32)

Is Mycobacterial InhA a Suitable Target for Rational Drug Design? Julien Rizet,Laurent Maveyraud,David Rengel,Valérie Guillet,Gabriel Publicolaet al. ChemMedChem, 2025, ⟨10.1002/cmdc.202500079⟩ Article dans une revue hal-05057386v1
The structural features and immunological role of biomphalysins in the snail Biomphalaria glabrata Pierre Poteaux,Aline Parpinel,Chantal Ripoll,Amélie Sarrazin,Richard Galinieret al. PLoS Pathogens, 2025, 21 (6), pp.e1013225. ⟨10.1371/journal.ppat.1013225⟩ Article dans une revue hal-05152561v1
Exploring the plasticity of the InhA substrate-binding site using new diaryl ether inhibitors Rasoul Tamhaev,Emeline Grosjean,Hikmat Ahamed,Mélina Chebaiki,Deborah Recchiaet al. Bioorganic Chemistry, 2024, 143, pp.107032. ⟨10.1016/j.bioorg.2023.107032⟩ Article dans une revue hal-04389877v1
The conserved yeast protein Knr4 involved in cell wall integrity is a multi-domain intrinsically disordered protein Manon Batista,Ellen I.M. Donker,Cécile Bon,Myriam Guillien,Adriana Caissoet al. Journal of Molecular Biology, 2023, 435 (10), pp.168048. ⟨10.1016/j.jmb.2023.168048⟩ Article dans une revue hal-03874437v2
Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA Mélina Chebaiki,Evelyne Delfourne,Rasoul Tamhaev,Saïda Danoun,Frédéric Rodriguezet al. European Journal of Medicinal Chemistry, 2023, 259, pp.115646. ⟨10.1016/j.ejmech.2023.115646⟩ Article dans une revue hal-04244940v1
Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis Nguyen-Hung Le,Patricia Constant,Samuel Tranier,Virginie Nahoum,Valérie Guilletet al. Bioorganic and Medicinal Chemistry Letters, 2022, 71, pp.116938. ⟨10.1016/j.bmc.2022.116938⟩ Article dans une revue hal-03758907v1
Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from Mycobacterium tuberculosis Romain Galy,Stéphanie Ballereau,Yves Génisson,Lionel Mourey,Jean-Christophe Plaqueventet al. Pharmaceuticals, 2021, 14 (12), pp.1282. ⟨10.3390/ph14121282⟩ Article dans une revue hal-03683937v1
Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds Coralie Carivenc,Laurent Maveyraud,Claire Blanger,Stéphanie Ballereau,Coralie Roy-Camilleet al. Scientific Reports, 2021, 11 (1), pp.18042. ⟨10.1038/s41598-021-97197-4⟩ Article dans une revue hal-03345048v1
Protein X-ray Crystallography and Drug Discovery Laurent Maveyraud,Lionel Mourey Molecules, 2020, 25 (5), pp.1030. ⟨10.3390/molecules25051030⟩ Article dans une revue hal-02950589v1
Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases Anna D Grabowska,Yoann Brison,Laurent Maveyraud,Sabine Gavalda,Alexandre Failleet al. ACS Chemical Biology, 2020, 15 (12), pp.3206 - 3216. ⟨10.1021/acschembio.0c00772⟩ Article dans une revue hal-03752170v2
Publisher Correction: Structural insights into chaperone addiction of toxin-antitoxin systems Valérie Guillet,Patricia Bordes,Cécile Bon,Julien Marcoux,Virginie Gervaiset al. Nature Communications, 2019, 10 (1), pp.1187. ⟨10.1038/s41467-019-09110-3⟩ Article dans une revue hal-04770998v1
Structural insights into chaperone addiction of toxin-antitoxin systems Valerie Guillet,Patricia Bordes,Cécile Bon,Julien Marcoux,Virginie Gervaiset al. Nature Communications, 2019, 10 (1), pp.782. ⟨10.1038/s41467-019-08747-4⟩ Article dans une revue hal-02335509v1
Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components Luis F Garcia-Alles,Katharina Root,Laurent Maveyraud,Nathalie Aubry,Eric Lesniewskaet al. PLoS ONE, 2019, 14 (10), pp.e0223877. ⟨10.1371/journal.pone.0223877⟩ Article dans une revue hal-03841381v1
An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors Aurélien Chollet,Laurent Maveyraud,Christian Lherbet,Vania Bernardes-Génisson European Journal of Medicinal Chemistry, 2018, 146, pp.318-343. ⟨10.1016/j.ejmech.2018.01.047⟩ Article dans une revue hal-01952876v1
Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases Alexandre Faille,Sabine Gavalda,Nawel Slama,Christian Lherbet,Laurent Maveyraudet al. Journal of Molecular Biology, 2017, 429 (47), pp.1554 - 1569. ⟨10.1016/j.jmb.2017.03.026⟩ Article dans une revue hal-03002100v1
Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria Valérie Guillet,Ségolène Galandrin,Laurent Maveyraud,Simon Ladevèze,Vincent Mariauleet al. Journal of Biological Chemistry, 2016, 291 (15), pp.7973-7989. ⟨10.1074/jbc.M115.712612⟩ Article dans une revue hal-03002148v1
Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach Aurélien Chollet,Lionel Mourey,Christian Lherbet,Alexandra Delbot,Sylviane Julienet al. Journal of Structural Biology, 2015, 190, pp.328 - 337. ⟨10.1016/j.jsb.2015.04.008⟩ Article dans une revue hal-03002973v1
Crystallographic studies of the structured core domain of Knr4 fromSaccharomyces cerevisiae Sylviane Julien,Patrick Tondl,Fabien Durand,Adilia Dagkessamanskaia,Herman van Tilbeurghet al. Acta crystallographica Section F : Structural biology communications [2014-..], 2015, 71 (9), pp.1120 - 1124. ⟨10.1107/s2053230x15012522⟩ Article dans une revue hal-03002962v1
Residues Essential for Panton-Valentine Leukocidin S Component Binding to Its Cell Receptor Suggest Both Plasticity and Adaptability in Its Interaction Surface Benoit-Joseph Laventie,Frédéric Guerin,Lionel Mourey,Mira y Tawk,Emmanuel Joveret al. PLoS ONE, 2014, 9 (3), pp.e92094. ⟨10.1371/journal.pone.0092094⟩ Article dans une revue hal-03002978v1
Crystallization and preliminary crystallographic studies of both components of the staphylococcal LukE–LukD leukotoxin Romain Galy,Fabien Bergeret,Daniel Keller,Lionel Mourey,Gilles Prévostet al. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2012, 68, pp.663 - 667. ⟨10.1107/s1744309112014662⟩ Article dans une revue hal-03003049v1
Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes Luis Garcia-Alles,Gaelle Giacometti,Cees Versluis,Laurent Maveyraud,Diane de Paepeet al. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (32), pp.13230 - 13235. ⟨10.1073/pnas.1105627108⟩ Article dans une revue hal-03003375v1
Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids L F Garcia-Alles,A Collmann,C Versluis,B Lindner,J Guiardet al. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (43), pp.17755 - 17760. ⟨10.1073/pnas.1110118108⟩ Article dans une revue hal-03003377v1
Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra Laurent Maveyraud,Hideaki Niwa,Valérie Guillet,Dmitri I Svergun,Peter V Konarevet al. Proteins - Structure, Function and Bioinformatics, 2008, 75, pp.89 - 103. ⟨10.1002/prot.22222⟩ Article dans une revue istex hal-03003386v1
A covalent S-F heterodimer of leucotoxin reveals molecular plasticity of β-barrel pore-forming toxins Pierre Roblin,Valérie Guillet,Olivier R. Joubert,Daniel Keller,Monique Erardet al. Proteins - Structure, Function and Bioinformatics, 2008, 71, pp.485 - 496. ⟨10.1002/prot.21900⟩ Article dans une revue istex hal-03003397v1
Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b Luis Garcia-Alles,Kees Versluis,Laurent Maveyraud,Ana Tesouro Vallina,Sebastiano Sansanoet al. EMBO Journal, 2006, 25 (15), pp.3684 - 3692. ⟨10.1038/sj.emboj.7601244⟩ Article dans une revue hal-03003440v1
6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of .BETA.-Lactamases. Dasantila Golemi,Laurent Maveyraud,Akihiro Ishiwata,Samuel Tramer,Kazuyuki Miyashitaet al. Journal of Antibiotics, 2000, 53 (10), pp.1022-1027. ⟨10.7164/antibiotics.53.1022⟩ Article dans une revue hal-03004369v1
The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins Jean-Denis Pedelacq,Laurent Maveyraud,Gilles Prévost,Lamine Baba-Moussa,Ana Gonzálezet al. Structure, 1999, 7 (3), pp.277-287. ⟨10.1016/s0969-2126(99)80038-0⟩ Article dans une revue istex hal-03004378v1
Crystal structure of Escherichia coli methionyl-tRNA synthetase highlights species-specific features. Yves Mechulam,Emmanuelle Schmitt,Laurent Maveyraud,Charles Zelwer,Osamu Nurekiet al. Journal of Molecular Biology, 1999, 294 (5), pp.1287-1297. ⟨10.1006/jmbi.1999.3339⟩ Article dans une revue istex hal-00841066v1
X-ray Analysis of the NMC-A β-Lactamase at 1.64-Å Resolution, a Class A Carbapenemase with Broad Substrate Specificity Peter Swarén,Laurent Maveyraud,Xavier Raquet,Stéphanie Cabantous,Colette Duezet al. Journal of Biological Chemistry, 1998, 273 (41), pp.26714-26721. ⟨10.1074/jbc.273.41.26714⟩ Article dans une revue hal-03004553v1
Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A β-Lactamases from the Antibiotic-Resistant Bacteria Laurent Maveyraud,Lionel Mourey,Lakshmi P Kotra,Jean-Denis Pedelacq,Valérie Guilletet al. Journal of the American Chemical Society, 1998, 120 (38), pp.9748-9752. ⟨10.1021/ja9818001⟩ Article dans une revue istex hal-03004592v1
Structural Basis of Extended Spectrum TEM ␤-Lactamases CRYSTALLOGRAPHIC, KINETIC, AND MASS SPECTROMETRIC INVESTIGATIONS OF ENZYME MUTANTS* Laurent Maveyraud,Isabelle Saves,Odile Burlet-Schiltz,Peter Swarén,Jean-Michel Massonet al. Journal of Biological Chemistry, 1996, 271 (18), pp.10482-10489. ⟨10.1074/jbc.271.18.10482⟩ Article dans une revue hal-03004742v1
Electrostatic analysis of TEM1 -lactamase: effect of substrate binding, steep potential gradients and consequences of site-directed mutations Peter Swarén,Laurent Maveyraud,Valérie Guillet,Jean-Michel Masson,Lionel Moureyet al. Structure, 1995, 3 (6), pp.603-613. ⟨10.1016/s0969-2126(01)00194-0⟩ Article dans une revue hal-03004753v1

Communication dans un congrès (7)

Ma techno en 180 s : La Synthèse Cinétique Guidée par la Cible Julien Rizet,Mélina Chebaiki,S. Danoun,Gabriel Publicola,Laurent Maveyraudet al. 25 ans de Genotoul et Assemblée Générale, INRAE, Dec 2024, Auzeville-Tolosane, France Communication dans un congrès hal-05381683v1
Biochemical and structural evidences that the human glutathion S-transferase A1 catalyzes the biosynthesis of dendrogenins. Silia Ayadi,Georges Ndikoum-Matip,Philippe de Medina,Regis Soules,Virginie Nahoumet al. 12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France Communication dans un congrès inserm-05029665v1
Macrocyclisation in situ by confinement: proof of concept and application to the design of new macrocyclic inhibitors of the InhA enzyme Melina Chebaiki,Christian Lherbet,Laurent Maveyraud,Lionel Mourey SECO 59, 16-20 mai 2022, May 2022, La Londe-Les-Maures, France Communication dans un congrès hal-03690361v1
GSTA1-1 is a multifunctional enzyme involved in 5,6α-epoxycholesterol conjugation with biological nucleophiles Silia Ayadi,Georges Ndikoum-Matip,Philippe de Medina,Virginie Nahoum,Laurent Maveyraudet al. 11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway Communication dans un congrès inserm-05029750v1
La chimie click in situ pour la formation de nouveaux inhibiteurs d’InhA de Mycobacterium tuberculosis Melina Chebaiki,Lionel Mourey,L. Maveyraud,Christian Lherbet GDR - ChemBiologie, Jun 2022, Toulouse, France Communication dans un congrès hal-03811107v1
Characterization of a cholesterol metabolic switch controlling breast carcinogenesis Philippe de Medina,Silia Ayadi,Emmanuel Noguer,Lisa Barrett,Regis Souleset al. 10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom Communication dans un congrès inserm-05029820v1
Approaching the 3D structure of a fungal conserved hub protein Hélène Martin-Yken,Sylviane Julien,Lionel Mourey,Jean-Marie François,Laurent Maveyraudet al. 27. International Conference on Yeast Genetics and Molecular Biology (ICYGMB), Fondazione Edmund Mach. ITA., Sep 2015, Levico Terme, Italy. 1 p Communication dans un congrès hal-02742124v1

Poster de conférence (19)

Towards first-in-class inhibitors of Mycobacterium tuberculosis and M. abscessus Phosphopantetheinyl transferases: a fragment-based approach Dylan El Faudel,Gabriel Publicola,Stéphanie Ballereau,Isabelle Fabing,Virginie Nahoumet al. Journée commune DCO-SCT (avancées en chimie organique pour la chimie médicinale), Jun 2025, Lille, France Poster de conférence hal-05379835v1
TagInhA: towards the discovery of direct inhibitors of InhA from M. tuberculosis and M. abscessus by pro-tein-guided fragment ligation Julien Rizet,Mélina Chebaiki,Rasoul Tamhaev,S. Danoun,Joëlle Azéma-Despeyrouxet al. 10th IPBS Student Symposium, Nov 2025, Toulouse, France Poster de conférence hal-05379435v1
Design Inhibitors of Phosphopantetheinyl Transferases Of Pathogenesis bacteria (M. tuberculosis and M. abscessus) Dylan El Faudel,Gabriel Publicola,Stéphanie Ballereau,Lionel Mourey,Laurent Maveyraudet al. 10th IPBS Student Symposium, Nov 2025, Toulouse, France Poster de conférence hal-05379399v1
Conception d’une banque de fragment fluorés générique et criblage par RMN 19F sur la protéine cible InhA. D. Begue,Rasoul Tamhaev,P.. Ramos,Virginie Nahoum,Stéphanie Ballereauet al. 5èmes Journées de la Chimiothèque Nationale – ChemBioFrance, May 2024, Toulouse, France Poster de conférence hal-04736850v1
Targeting an old target: design of direct inhibitors of the InhA enzyme to fight mycobacterial infections Mélina Chebaiki,Rasoul Tamhaev,Laurent Maveyraud,Christian Lherbet,Lionel Mourey MYCODAYS Symposium, Jul 2024, Lille, France Poster de conférence hal-04796042v1
Design of inhibitors of phosphopantetheinyl transferases of pathogenic bacteria (M. tuberculosis and M. abscessus) Dylan El Faudel,Gabriel Publicola,Stéphanie Ballereau,Virginie Nahoum,Lionel Moureyet al. « 9e Symposium des étudiants et étudiantes de l’IPBS », Nov 2024, Toulouse, France Poster de conférence hal-05380229v1
Towards the discovery of new inhibitors of the InhA protein of Mycobacterium tuberculosis by self-assembly: use of KTGS and DCX Julien Rizet,Mélina Chebaiki,Rasoul Tamhaev,Saïda Danoun,Joëlle Azéma-Despeyrouxet al. Les 30 ans de l’Institut de Chimie de Toulouse”, Université Toulouse III – Paul Sabatier, Sep 2024, Toulouse, France Poster de conférence hal-04732345v1
Towards the discovery of new inhibitors of the InhA protein of Mycobacterium tuberculosis by self-assembly: use of KTGS and DCX Julien Rizet,Mélina Chebaiki,Rasoul Tamhaev,Saïda Danoun,Joëlle Azéma-Despeyrouxet al. « 9e Symposium des étudiants et étudiantes de l’IPBS », Nov 2024, Toulouse, France Poster de conférence hal-05380260v1
Biomphalysins: Aerolysin-like toxins from Biomphalaria glabrata snail Pierre Poteaux,Aline Parpinel,Benjamin Gourbal,Laurent Maveyraud,David Duval Etox Meeting, Jun 2023, Perthshire, United Kingdom Poster de conférence hal-04884487v1
Conception, synthesis and evaluation of new inhibitors of Mycobacterium abscessus InhA Adèle Brison,Rasoul Tamhaev,Joëlle Azéma-Despeyroux,Laurent Maveyraud,Lionel Moureyet al. Journée scientifique toulousaine de Chimie-Biologie-Santé (JCBS), Apr 2023, Toulouse, France Poster de conférence hal-04199164v1
Dynamic Combinatorial X-Ray crystallography : Toward new inhibitors of InhA, an essential enzyme from Mycobacterium tuberculosis” R. Tamhaev,Laurent Maveyraud,Lionel Mourey,Christian Lherbet 9ème Ecole RéNaFoBiS (Réseau National de Formation en Biologie Structurale Intégrative), Jun 2022, OLERON, France Poster de conférence hal-03812179v1
Dynamic Combinatorial X-ray crystallography: toward new inhibitors of InhA, an essential enzyme from Mycobacterium tuberculosis Rasoul Tamhaev,Laurent Maveyraud,Lionel Mourey,Christian Lherbet European Crystallography Meeting, 33rd edition, Aug 2022, Versailles, France Poster de conférence hal-04192428v1
In situ click chemistry for the formation of novel InhA inhibitors of Mycobacterium tuberculosis Melina Chebaiki,Evelyne Delfourne,Saïda Danoun,Isabelle Fabing,Laurent Maveyraudet al. Journée de Chimie du Grand Sud-Ouest, Jul 2022, Toulouse, France Poster de conférence hal-03812172v1
Vers de nouveaux inhibiteurs d'InhA découverts par cristallographie combinatoire dynamique aux rayons X R. Tamhaev,Laurent Maveyraud,Lionel Mourey,Christian Lherbet 2ème Journées Scientifique du GDR ChemBio– 34ieme Journée Chimie - biologie - Santé, Jun 2022, Toulouse, France Poster de conférence hal-03685340v1
The Integrated Screening Platform of Toulouse (PICT): a tool for accelerated molecular discovery Yves Génisson,Michel Baltas,Isabelle Fabing,Stéphanie Ballereau,Brigitte Guidettiet al. Congrès FICS (French Industrial Chemistry Symposium), Mar 2020, Paris, France Poster de conférence hal-04906767v1
The integrated screening platform of Toulouse (PICT) : A tool for accelerated molecular discovery Brigitte Guidetti,Isabelle Fabing,Michel Baltas,Stéphanie Ballereau,Tessa Castellanet al. 33e journée Chimie-Biologie-Santé, Apr 2019, Toulouse, France Poster de conférence hal-02338497v1
The integrated screening platform of Toulouse (PICT) : A tool for accelerated molecular discovery Isabelle Fabing,Michel Baltas,Stéphanie Ballereau,Tessa Castellan,Yves Génissonet al. 10th International Chemistry Conference Toulouse-Kiev (ICTK-10), Jun 2019, Toulouse, France Poster de conférence hal-02335559v1
The integrated screening platform of Toulouse (PICT) : A tool for accelerated molecular discovery Isabelle Fabing,Michel Baltas,Stéphanie Ballereau,Yves Génisson,Brigitte Guidettiet al. Congress SFC 2018 Chemistry and Life Symposium, Jun 2018, Montpellier, France Poster de conférence hal-02337455v1
A Structural Approach to Discover an Achilles'heel of fungi : the case of Knr4/Smi1 Hélène Martin-Yken,Didier Zerbib,Sylviane Julien,Lionel Mourey,Laurent Maveyraudet al. Fungal Cell Wall Meeting, Oct 2015, Paris, France Poster de conférence hal-02951422v1

Chapitre d'ouvrage (1)

Molecular Dynamics as a Tool for Virtual Ligand Screening Grégory Menchon,Laurent Maveyraud,Georges Czaplicki Computational Drug Discovery and Design, 2714, pp.33-83, 2024, Methods in Molecular Biology, ⟨10.1007/978-1-0716-3441-7_3⟩ Chapitre d'ouvrage hal-04258325v1