laurent Micouin

68
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Présentation

MICOUIN Laurent

CNRS Research Director first class, UMR 8601 Paris Descartes

Laboratoire de Chimie et de Biochimie pharmacologiques et toxicologiques

45, rue des Saints Pères, 75006 Paris, France

Phone + (33) 1 42 86 20 40, Fax + (33) 1 42 86 83 87

e-mail : laurent.micouin@parisdescartes.fr

Born on March 6th 1968, Clermont Ferrand, France

Academic and Professional Background :

2014- CNRS Research Director, first class (UMR 8601, University Paris Descartes)

2012-2014 CNRS Research Director, second class (UMR 8601, University Paris Descartes)

2005-2012 CNRS Research Director, second class (UMR 8638, University Paris Descartes)

2000-2005 CNRS Associate Scientist, first class (UMR 8638, University Paris Descartes)

2000 Habilitation, University Paris Descartes, Paris, France

1996-2000 CNRS Associate Scientist, second class (UMR 8638, University Paris Descartes)

1995- 1996 Post-Doctoral Fellow, University Marburg, Germany (with Prof. P.Knochel)

1992-1995 PhD in Chemistry, University Paris 5 (with Prof. J.-C. Quirion and Prof. H.-P. Husson)

1990-1992 Research Assistant, Institut Malardé, French Polynesia

1990 Master in Chemistry, University Paris 6 (With Prof. P. Cresson)

1990 Engineer in Chemistry, ENSCP (Chemistry National School), Paris.

Scientific Record:

96 publications, 8 patents, book chapters, 1 book co-editor (Patai), 66 invited conferences or seminars

Scientific interests

- Diversity-oriented synthesis of bioactive compounds or tools for biological investigations.

- New chemical methods for the fragment-based synthesis of RNA binders

- New synthetic methods for the preparation of organoaluminum reagents

Official capacities

2019-

2016-

2015-2018

2012-2018

2011- 2013

2010- 2012

Director of UMR 8601

Member of the CNRS national Committee (section 16).

CNRS Deputy director of UMR 8601

Head of the Doctoral School 563 MTCI "Medecines, Toxicology, Chemistry, Imaging), board member of several doctoral schools.

CNRS Scientific Officer (chargé de mission), National Chemistry Institute, CNRS Deputy director of UMR 8638

Honors and awards

2007 Invited Professor (Puebla University, Mexico)

2005 French Chemical Society Acros prize

1996 Roussel (PhD) prize of Paris 5 University

1995 Alexander Von Humboldt post-doctoral fellowship

Publications

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Publications

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Exploring the RNA‐Binding Potential of Three‐Dimensional Cyanines Derived From [2.2]Paracyclophane: A Structure–Property Relationship

Rongyu Sun , Cristian Siretanu , Georgina Ilieska , Simon Felder , Erica Benedetti et al.

ChemBioChem, 2026, 27 (1), pp.e202500835. ⟨10.1002/cbic.202500835⟩

Article dans une revue hal-05457081v1
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An Overview of the Direct Preparation of Organoaluminum Compounds

Riccardo Piccardi , Laurent Micouin

Synthesis: Journal of Synthetic Organic Chemistry, In press, ⟨10.1055/a-2669-5996⟩

Article dans une revue (article de synthèse) hal-05302402v1
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Development of Comprehensive Screening and Assessment Assays for Small-Molecule Ligands of MALAT1 lncRNA

Mélanie Pernak , Claire Fleurisson , Cécile Delorme , Roba Moumné , Erica Benedetti et al.

ACS Chemical Biology, 2025, 20 (5), pp.1068-1076. ⟨10.1021/acschembio.5c00061⟩

Article dans une revue hal-05363583v1
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α‐Silylated Diazoalkynes: New Tools for Bioconjugation of Proteins

Tuan Zhao , Emmanuelle Sachon , Laurent Micouin , Riccardo Piccardi

Chemistry - A European Journal, 2024, 30 (19), pp.2042-2048. ⟨10.1002/chem.202302807⟩

Article dans une revue hal-04762411v1
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Design and Evaluation of Azaspirocycles as RNA binders

Claire Fleurisson , Nessrine Graidia , Jihed Azzouz , Audrey Di Giorgio , Marc Gaysinski et al.

Chemistry - A European Journal, 2024, 31 (5), pp.e202403518. ⟨10.1002/chem.202403518⟩

Article dans une revue hal-05302366v1
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Have spirocyclic scaffolds been properly utilized in recent drug discovery efforts?

Erica Benedetti , Laurent Micouin

Expert Opinion on Drug Discovery, 2024, 19 (3), pp.263-266. ⟨10.1080/17460441.2024.2305735⟩

Article dans une revue hal-04736219v1
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[2.2]Paracyclophanes: From Selective Functionalization to Optical Properties

Shiqi Wu , Simon Felder , Jules Brom , Fabrice Pointillart , Olivier Maury et al.

Advanced Optical Materials, 2024, 12 (21), pp.2400934. ⟨10.1002/adom.202400934⟩

Article dans une revue hal-04614001v1
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Magneto-structural correlation in lanthanide luminescent [2.2]Paracyclophane-based Single-Molecule Magnets

Hadrien Flichot , Annika Sickinger , Jules Brom , Bertrand Lefeuvre , Vincent Dorcet et al.

Dalton Transactions, 2024, 53 (19), pp.8191-8201. ⟨10.1039/d4dt00536h⟩

Article dans une revue hal-04571100v1
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Compact CPL emitters based on a [2.2]paracyclophane scaffold: recent developments and future perspectives

Simon Felder , Marie-Leonie Delcourt , Damian Contant , Rafael Rodríguez , Ludovic Favereau et al.

Journal of Materials Chemistry C, 2023, 11, pp.2053-2062. ⟨10.1039/d2tc04885j⟩

Article dans une revue hal-04011240v1
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Intramolecular Buchwald–Hartwig N -arylation of bicyclic hydrazines: practical access to spiro[indoline-2,3′-piperidines]

Claire Fleurisson , Nessrine Graidia , Yann Foricher , Erica Benedetti , Laurent Micouin

Organic & Biomolecular Chemistry, 2023, 21 (17), pp.3542-3546. ⟨10.1039/D3OB00406F⟩

Article dans une revue hal-04267385v1
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Light-Driven Reductive Cleavage of Sulfonamides Promoted by Thiourea Organophotosensitizers

Jules Brom , Antoine Maruani , Laurent Micouin , Erica Benedetti

Journal of Organic Chemistry, 2023, 88 (9), pp.5923-5935. ⟨10.1021/acs.joc.3c00296⟩

Article dans une revue hal-04267371v1
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Planar Chiral Analogues of PRODAN Based on a [2.2]Paracyclophane Scaffold: Synthesis and Photophysical Studies

Simon Felder , Marie-Leonie Delcourt , Manon Bousquet , Denis Jacquemin , Rafael Rodriguez et al.

Journal of Organic Chemistry, 2022, 87 (1), pp.147-158. ⟨10.1021/acs.joc.1c02071⟩

Article dans une revue hal-03512519v1
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Small-Molecule 3D Ligand for RNA Recognition: Tuning Selectivity through Scaffold Hopping

Simon Felder , Corinne Sagné , Erica Benedetti , Laurent Micouin

ACS Chemical Biology, 2022, 17 (11), pp.3069-3076. ⟨10.1021/acschembio.2c00171⟩

Article dans une revue hal-04035021v1
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Enantiopure planar chiral [2.2]paracyclophanes: Synthesis and applications in asymmetric organocatalysis

Simon Felder , Shiqi Wu , Jules Brom , Laurent Micouin , Erica Benedetti

Chirality, 2021, 33 (9), pp.506-527. ⟨10.1002/chir.23335⟩

Article dans une revue hal-03366196v1
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Para‐Functionalization of N‐Substituted 4‐amino[2.2]paracyclophanes by Regioselective Formylation

Simon Felder , Laurent Micouin , Erica Benedetti

European Journal of Organic Chemistry, 2021, pp.4015. ⟨10.1002/ejoc.202100288⟩

Article dans une revue hal-03297447v1
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Tuning the excited state properties of [2.2]paracyclophane-based antennas to ensure efficient sensitization of lanthanide ions or singlet oxygen generation

Shiqi Wu , Laura Abad Galán , Margaux Roux , François Riobé , Boris Le Guennic et al.

Inorganic Chemistry, 2021, 60 (60), pp.21. ⟨10.1021/acs.inorgchem.1c01986⟩

Article dans une revue hal-03407500v1
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Revised structure of anthelvencin A and characterization of the anthelvencin biosynthetic gene cluster

Céline Aubry , Paolo Clerici , Claude Gerbaud , Laurent Micouin , Jean-Luc Pernodet et al.

ACS Chemical Biology, 2020, ⟨10.1021/acschembio.9b00960⟩

Article dans une revue hal-02502312v1
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Cyclic cis-1,3-Diamines Derived from Bicyclic Hydrazines: Synthesis and Applications

Claire Fleurisson , Erica Benedetti , Laurent Micouin Article dans une revue hal-03003668v1
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3D Coumarin Systems Based on [2.2]Paracyclophane Synthesis, Spectroscopic Characterization, and Chiroptical Properties

Marie-Leonie Delcourt , Corentin Reynaud , Serge Turcaud , Ludovic Favereau , Jeanne Crassous et al.

Journal of Organic Chemistry, 2019, 84 (2), pp.888-899. ⟨10.1021/acs.joc.8b02773⟩

Article dans une revue hal-02049506v1
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Synthesis of Organometallic Compounds in Flow

Tuan Zhao , Laurent Micouin , Riccardo Piccardi

Helvetica Chimica Acta, 2019, 102 (11), ⟨10.1002/hlca.201900172⟩

Article dans une revue hal-02346965v1

Highly Enantioselective Asymmetric Transfer Hydrogenation: A Practical and Scalable Method To Efficiently Access Planar Chiral [2.2]Paracyclophanes

Marie-Leonie Delcourt , Simon Felder , Serge Turcaud , Corina Pollok , Christian Merten et al.

Journal of Organic Chemistry, 2019, ⟨10.1021/acs.joc.9b00372⟩

Article dans une revue hal-02113386v1
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Highly Enantioselective Desymmetrization of Centrosymmetric pseudo - para -Diformyl[2.2]paracyclophane via Asymmetric Transfer Hydrogenation

Marie-Leonie Delcourt , Simon Felder , Erica Benedetti , Laurent Micouin

ACS Catalysis, 2018, 8 (7), pp.6612-6616. ⟨10.1021/acscatal.8b01872⟩

Article dans une revue hal-02113395v1
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Rapid and Effective Synthesis of α-Acyloxy-α-alkynyltrimethylsilanes

Tuan Zhao , Riccardo Piccardi , Laurent Micouin

Organic Letters, 2018, 20 (16), pp.5015-5018. ⟨10.1021/acs.orglett.8b02165⟩

Article dans une revue hal-02113392v1
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Diastereoselective Ring Homologation of Bicyclic Hydrazines: Access to cis -1,3-Diaminocyclohexitols

Aurélie Blond , Serge Turcaud , Thomas Lecourt , Laurent Micouin

ACS Omega, 2018, 3 (11), pp.15302-15307. ⟨10.1021/acsomega.8b02910⟩

Article dans une revue hal-02186751v1
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Synthesis and Reactivity of Mixed Dimethylalkynylaluminum Reagents

Riccardo Piccardi , Serge Turcaud , Erica Benedetti , Laurent Micouin

Synthesis: Journal of Synthetic Organic Chemistry, 2018, 51 (01), pp.97-106. ⟨10.1055/s-0037-1610392⟩

Article dans une revue hal-02113388v1
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Synthesis and photophysical studies of through-space conjugated [2.2]paracyclophane-based naphthalene fluorophores

E. Benedetti , M.-L. Delcourt , B. Gatin-Fraudet , S. Turcaud , L. Micouin

RSC Advances, 2017, 7 (80), pp.50472-50476. ⟨10.1039/C7RA10038H⟩

Article dans une revue hal-02113405v1

Substitution of the Participating Group of Glycosyl Donors by a Halogen Atom: Influence on the Rearrangement of Transient Orthoesters Formed during Glycosylation Reactions

Antoine Joosten , Mélissa Boultadakis-Arapinis , V. Gandon , L. Micouin , Thomas Lecourt

Journal of Organic Chemistry, 2017, 82 (6), pp.3291-3297. ⟨10.1021/acs.joc.6b03088⟩

Article dans une revue hal-02046285v1
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Use of a redox probe for an electrochemical RNA–ligand binding assay in microliter droplets

Hélène Guyon , François Mavré , Marjorie Catala , Serge Turcaud , Franck Brachet et al.

Chemical Communications, 2017, 53 (6), pp.1140-1143. ⟨10.1039/c6cc07785d⟩

Article dans une revue hal-02185366v1

Continuous Flow Synthesis of Dimethylalkynylaluminum Reagents

Riccardo Piccardi , Anaïs Coffinet , Erica Benedetti , Serge Turcaud , Laurent Micouin

Synthesis: Journal of Synthetic Organic Chemistry, 2016, 48 (19), pp.3272-3278. ⟨10.1055/s-0035-1561484⟩

Article dans une revue hal-02134269v1
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Rhodium(II)-Alkynyl Carbenoids Insertion into Si–H bonds: An Entry to Propargylic Geminal Bis(silanes)

Thibaut Courant , Rahul Kumar , Serge Turcaud , Laurent Micouin

Organic Letters, 2016, 18 (19), pp.4818-4820. ⟨10.1021/acs.orglett.6b02264⟩

Article dans une revue hal-02186746v1

Monitoring of reversible boronic acid–diol interactions by fluorine NMR spectroscopy in aqueous media

Laura Iannazzo , Erica Benedetti , Marjorie Catala , Mélanie Etheve-Quelquejeu , Carine Tisné et al.

Organic & Biomolecular Chemistry, 2015, 13 (33), pp.8817-8821. ⟨10.1039/c5ob01362c⟩

Article dans une revue hal-03544508v1

Electronic Effects in Carbene-Mediated C H Bond Functionalization: An Experimental and Theoretical Study

Mélissa Boultadakis-Arapinis , Vincent Gandon , Elise Prost , Laurent Micouin , Thomas Lecourt

Advanced Synthesis and Catalysis, 2014, 356 (11-12), pp.2493-2450. ⟨10.1002/adsc.201300984⟩

Article dans une revue istex hal-01141166v1
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The Reaction of Dimethylalkynylaluminum Reagents with Trimethylsilyldiazomethane: Original Reactivity Leading to New α-Silylated Alkynyl Hydrazones

Rahul Kumar , Serge Turcaud , Laurent Micouin

Organic Letters, 2014, 16 (23), pp.6192-6195. ⟨10.1021/ol503113d⟩

Article dans une revue hal-02185384v1
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Modular Access to N-Substituted cis -3,5-Diaminopiperidines

Aurélie Blond , Paul Dockerty , Raquel Alvarez , Serge Turcaud , Thomas Lecourt et al.

Journal of Organic Chemistry, 2013, 78 (23), pp.12236-12242. ⟨10.1021/jo401994y⟩

Article dans une revue hal-02186757v1

Carbene-Mediated Functionalization of the Anomeric C-H Bond of Carbohydrates: Scope and Limitations

Mélissa Boultadakis-Arapinis , Elise Prost , Vincent Gandon , Pascale Lemoine , Serge Turcaud et al.

Chemistry - A European Journal, 2013, 19 (19), pp.6052-6066. ⟨10.1002/chem.201203725⟩

Article dans une revue istex hal-02185449v1

Investigation of RNA-Ligand Interactions by (19) F NMR Spectroscopy Using Fluorinated Probes.

Thomas Lombès , Roba Moumné , Valéry Larue , Elise Prost , Marjorie Catala et al.

Angewandte Chemie International Edition, 2012, 51 (38), pp.9530-9534. ⟨10.1002/anie.201204083⟩

Article dans une revue istex hal-00724894v1

Fragment-based design of small RNA binders: promising developments and contribution of NMR.

Roba Moumné , Marjorie Catala , Valéry Larue , Laurent Micouin , Carine Tisné

Biochimie, 2012, 94 (7), pp.1607-1619. ⟨10.1016/j.biochi.2012.02.002⟩

Article dans une revue istex hal-00692356v1
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Direct Synthesis of Polysubstituted Aluminoisoxazoles and Pyrazoles by a Metalative Cyclization

Olivier Jackowski , Thomas Lecourt , Laurent Micouin

Organic Letters, 2011, 13 (20), pp.5664-5667. ⟨10.1021/ol202389u⟩

Article dans une revue hal-02185376v1

Stereoselective synthesis of fluorinated 1,3-cis-diaminocyclopentanes.

Morgane Pasco , Roba Moumné , Thomas Lecourt , Laurent Micouin

Journal of Organic Chemistry, 2011, 76 (12), pp.5137-42. ⟨10.1021/jo2001512⟩

Article dans une revue hal-00649119v1
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Stereoselective Synthesis of Fluorinated 1,3- cis -Diaminocyclopentanes

Morgane Pasco , Roba Moumné , Thomas Lecourt , Laurent Micouin

Journal of Organic Chemistry, 2011, 76 (12), pp.5137-5142. ⟨10.1021/jo2001512⟩

Article dans une revue hal-02186896v1

Rhodium(II) carbene-mediated modification of 2-deoxystreptamine surrogates

A. Blond, , Roba Moumné , G. Begis, , M. Pasco , Thomas Lecourt et al.

Journal of Organic Chemistry, 2011, 52 (25), pp.3201-3203

Article dans une revue hal-00649113v1
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Direct Synthesis of 1,4-Disubstituted-5-alumino-1,2,3-triazoles: Copper-Catalyzed Cycloaddition of Organic Azides and Mixed Aluminum Acetylides

Yuhan Zhou , Thomas Lecourt , Laurent Micouin

Angewandte Chemie International Edition, 2010, 49 (14), pp.2607-2610. ⟨10.1002/anie.200907016⟩

Article dans une revue istex hal-02185392v1

Fluorinated diaminocyclopentanes as chiral sensitive NMR probes of RNA structure.

Roba Moumné , Morgane Pasco , Elise Prost , Thomas Lecourt , Laurent Micouin et al.

Journal of the American Chemical Society, 2010, 132 (38), pp.13111-3. ⟨10.1021/ja1037885⟩

Article dans une revue hal-00614591v1

Tether influence on the binding properties of tRNALys3 ligands designed by a fragment-based approach.

Roba Moumné , Valéry Larue , Bili Seijo , Thomas Lecourt , Laurent Micouin et al.

Organic & Biomolecular Chemistry, 2010, 8 (5), pp.1154-9. ⟨10.1039/b921232a⟩

Article dans une revue istex hal-00596199v1
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NMR-Guided Fragment-Based Approach for the Design of AAC(6′)-Ib Ligands

Thomas Lombès , Guillaume Bégis , Frédérique Maurice , Serge Turcaud , Thomas Lecourt et al.

ChemBioChem, 2008, 9 (9), pp.1368-1371. ⟨10.1002/cbic.200700677⟩

Article dans une revue istex hal-02185444v1
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Desymmetrization of meso-Bicyclic Hydrazines by Rhodium-Catalyzed Enantioselective Hydroformylation

Chloée Bournaud , Thomas Lecourt , Laurent Micouin , Catherine Méliet , Francine Agbossou-Niedercorn

European Journal of Organic Chemistry, 2008, 2008 (13), pp.2298-2302. ⟨10.1002/ejoc.200800116⟩

Article dans une revue istex hal-02185573v1
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NMR-guided fragment-based approach for the design of tRNA(Lys3) ligands.

Florence Chung , Carine Tisné , Thomas Lecourt , Frédéric Dardel , Laurent Micouin

Angewandte Chemie International Edition, 2007, 46 (24), pp.4489-91. ⟨10.1002/anie.200605201⟩

Article dans une revue hal-00218344v1
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NMR identification of ligands of aminoglycoside resistance enzymes

Frédérique Maurice , Guillaume Bégis , Laurent Micouin , Frédéric Dardel

Comptes Rendus. Chimie, 2006, 9, pp.413-419

Article dans une revue hal-00021873v1
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Asymmetric 1,3-Dipolar Cycloadditions of Cyclic Stabilized Ylides Derived from Chiral 1,2-Amino Alcohols

Martine Bonin , Laurent Micouin , Ariane Chauveau

SYNLETT, 2006, 2006 (15), pp.2349-2363. ⟨10.1055/s-2006-949626⟩

Article dans une revue hal-02185347v1

Synthesis and reactivity of mixed alkynylalanes by direct triethylamine-catalyzed alumination of terminal alkynes.

Christophe Feuvrie , Jérôme Blanchet , Martine Bonin , Laurent Micouin

Organic Letters, 2004, 6 (14), pp.2333-6. ⟨10.1021/ol049346v⟩

Article dans une revue hal-00909871v1

Total Enantioselective Synthesis and In Vivo Biological Evaluation of a Novel Fluorescent BODIPY α-Galactosylceramide

Yen Vo-Hoang , Laurent Micouin , Catherine Ronet , Gabriel Gachelin , Martine Bonin

ChemBioChem, 2003, 4 (1), pp.27-33. ⟨10.1002/cbic.200390009⟩

Article dans une revue istex hal-03531886v1
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Practical Asymmetric Synthesis of 1,2-Diamines in the 3-Aminoazepane Series

S. Cutri , A. Chiaroni , M. Bonin , L. Micouin , H.-P. Husson

Journal of Organic Chemistry, 2003, 68 (7), pp.2645-2651. ⟨10.1021/jo026711s⟩

Article dans une revue hal-02186903v1
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Enantioselective Desymmetrization of Meso Bicyclic Hydrazines: A Novel Approach to the Asymmetric Synthesis of Polysubstituted Amino Cyclopentanic Cores

A. Pérez Luna , M.-A Ceschi , M. Bonin , L. Micouin , H.-P. Husson et al.

Journal of Organic Chemistry, 2002, 67 (10), ⟨10.1021/jo011190e⟩

Article dans une revue hal-02186763v1

Recent progress in the asymmetric synthesis of α-substituted propargylamines

Jerome Blanchet , M. Bonin , L. Micouin

Organic Preparations and Procedures International : The New Journal for Organic Synthesis, 2002, 34 (5), pp.467-492. ⟨10.1080/00304940209355765⟩

Article dans une revue hal-02328004v1
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Reversal of Enantioselectivity in the Asymmetric Rhodium- versus Iridium-Catalyzed Hydroboration of Meso Substrates

Alejandro Pérez Luna , Martine Bonin , Laurent Micouin , Henri-Philippe Husson

Journal of the American Chemical Society, 2002, 124 (41), pp.12098-12099. ⟨10.1021/ja026714m⟩

Article dans une revue hal-02185596v1
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Isomerization of Chiral Non-Racemic α-Substituted Propargylic Amines to Terminal Acetylenes

Jérôme Blanchet , Martine Bonin , Laurent Micouin , Henri-Philippe Husson

European Journal of Organic Chemistry, 2002, 2002 (15), pp.2598-2602. ⟨10.1002/1099-0690(200208)2002:15<2598::AID-EJOC2598>3.0.CO;2-V⟩

Article dans une revue istex hal-02185592v1

Asymmetric synthesis of β-pseudopeptides from chiral 3,4-aziridinolactams

Jordi Piró , Pilar Forns , Jérôme Blanchet , Martine Bonin , Laurent Micouin et al.

Tetrahedron: Asymmetry, 2002, 13 (9), pp.995-1004. ⟨10.1016/S0957-4166(02)00221-5⟩

Article dans une revue istex hal-02328007v1

Asymmetric synthesis of α-substituted propynyl amines. Application to the preparation of a polysubstituted dihydroisoindoline framework

Jérôme Blanchet , Martine Bonin , Laurent Micouin , Henri-Philippe Husson

Tetrahedron Letters, 2001, 42 (18), pp.3171-3173. ⟨10.1016/S0040-4039(01)00356-2⟩

Article dans une revue istex hal-02328009v1

The Origin of Chemical and Configurational Stability of Chiral Nonracemic Tert-Butyl Aziridinecarboxylate Anions

Valérie Alezra , Martine Bonin , Laurent Micouin , Clotilde Policar , Henri-Philippe Husson

European Journal of Organic Chemistry, 2001, 2001 (13), pp.2589-2594. ⟨10.1002/1099-0690(200107)2001:13<2589::AID-EJOC2589>3.0.CO;2-Y⟩

Article dans une revue istex hal-02011971v1

Synthesis of enantiomerically pure alpha-substituted propargylic amines by reaction of organoaluminum reagents with oxazolidines.

J. Blanchet , M. Bonin , L. Micouin , H. P. Husson

Journal of Organic Chemistry, 2000, 65 (20), pp.6423-6

Article dans une revue hal-00909874v1

[2,3]-Meisenheimer rearrangement of N-allyl phenylglycinol derivatives. NC versus CC chirality transfer

Jérôme Blanchet , Martine Bonin , Laurent Micouin , Henri-Philippe Husson

Tetrahedron Letters, 2000, 41 (43), pp.8279-8283. ⟨10.1016/S0040-4039(00)01460-X⟩

Article dans une revue istex hal-02328033v1

Synthesis of Enantiomerically Pure α-Substituted Propargylic Amines by Reaction of Organoaluminum Reagents with Oxazolidines

Jerome Blanchet , M. Bonin , L. Micouin , H.-P. Husson

Journal of Organic Chemistry, 2000, 65 (20), pp.6423-6426. ⟨10.1021/jo0003706⟩

Article dans une revue istex hal-02328014v1

Diastereoselective alkynylation of chiral non-racemic oxazolidines with mixed organoaluminum compounds

Jérôme Blanchet , Martine Bonin , Angèle Chiaroni , Laurent Micouin , Claude Riche et al.

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