Pierre Layrolle Directeur de recherche Inserm - ToNIC UMR 1214Chef d'équipe 3D Chip 'Regeneration osseuse, Bio-impression 3D de tissus et organoïdes humains sur puces'

Identifiants chercheurs

IdHAL :

layrolle

ORCID :

0000-0001-9800-5210

ResearcherID :

K-9257-2015

Présentation

Pierre Layrolle has extensive experience in tissue engineering research both in industry and academia. He obtained his PhD in biomaterials in 1994 at the Polytechnic National Institute of Toulouse (FR) and his thesis was awarded the Leopold Escande prize. He completed his postdoctoral studies in Japan and later joined the tissue engineering company IsoTis (NL) prior to enter INSERM in Nantes. He was awarded the Jean Leray prize from the European Society for Biomaterials in 2007 and the 'Etoile de l'Europe' award from the French Ministry of Research in 2015. He recently moved to ToNIC to conduct research in 3D bioprinting of human osteoarticular tissues and brain organoids.Pierre Layrolle is inventor of 15 patents, authored about 250 peer-reviewed publications, member of the Editorial board of several journals (Acta Biomaterialia, Biomedical Materials, J Mater Sci Mater Med, Scientific Reports, Front Bioeng Biotech) and regularly invited to present at international conferences. He has also organized as chairman several conferences such as the European Society for Biomaterials in 2006, Bioceramics 20 in 2007, the European Orthopaedic Research Society conference in 2014 and the TERMIS workshop 3D bioprinting in cancer research in 2019.

Publications

Article dans une revue (51)

Bone Augmentation of Atrophic Alveolar Ridges Using a Synthetic Bone Substitute With Mesenchymal Stem Cells: A Randomized, Controlled Clinical Trial Mariano Sanz,Cecilie Gjerde,Bjørn Tore Gjertsen,Alberto Ortiz‐vigón,Nerea Sanchezet al. Clinical Oral Implants Research, 2025, 36 (11), pp.1498-1514. ⟨10.1111/clr.70025⟩ Article dans une revue hal-05524774v1
The Optic Nerve at Stake: Update on Environmental Factors Modulating Expression of Leber’s Hereditary Optic Neuropathy Pierre Layrolle,Christophe Orssaud,Maryse Leleu,Pierre Payoux,Stéphane Chavanas Biomedicines, 2024, 12 (3), pp.584. ⟨10.3390/biomedicines12030584⟩ Article dans une revue hal-04620523v1
Phase composition of calcium phosphate materials affects bone formation by modulating osteoclastogenesis Paul Humbert,Carina Kampleitner,Julien de Lima,Meadhbh Á Brennan,Irene Lodoso-Torrecillaet al. Acta Biomaterialia, 2024, 176, pp.417 - 431. ⟨10.1016/j.actbio.2024.01.022⟩ Article dans une revue hal-04591297v1
Bioengineering the Junctional Epithelium in 3D Oral Mucosa Models Marianna Gavriiloglou,Mira Hammad,Jordan M Iliopoulos,Pierre Layrolle,Danae A Apatzidou Journal of Functional Biomaterials, 2024, 15 (11), pp.330. ⟨10.3390/jfb15110330⟩ Article dans une revue hal-05517442v1
Message in a Scaffold: Natural Biomaterials for Three-Dimensional (3D) Bioprinting of Human Brain Organoids Pierre Layrolle,Pierre Payoux,Stéphane Chavanas Biomolecules, 2022, 13 (1), pp.25. ⟨10.3390/biom13010025⟩ Article dans une revue hal-04703014v1
A Comparative In Vitro and In Vivo Study of Osteogenicity by Using Two Biomaterials and Two Human Mesenchymal Stem Cell Subtypes L. Fievet,N. Serratrice,Bénédicte Brulin,L. Giraudo,J. Véranet al. Frontiers in Cell and Developmental Biology, 2022, 10, pp.913539. ⟨10.3389/fcell.2022.913539⟩ Article dans une revue hal-04703060v1
Microbial–stem cell interactions in periodontal disease Jordan Iliopoulos,Pierre Layrolle,Danae Apatzidou Journal of Medical Microbiology, 2022, 71 (4), ⟨10.1099/jmm.0.001503⟩ Article dans une revue hal-04703063v1
Chondrogenic and BMP-4 primings confer osteogenesis potential to human cord blood mesenchymal stromal cells delivered with biphasic calcium phosphate ceramics Meadhbh Á Brennan,Mario Barilani,Francesco Rusconi,Julien de Lima,Luciano Vidalet al. Scientific Reports, 2021, 11 (1), pp.6751. ⟨10.1038/s41598-021-86147-9⟩ Article dans une revue hal-04699769v1
Apoptotic mesenchymal stromal cells support osteoclastogenesis while inhibiting multinucleated giant cells formation in vitro Paul Humbert,Meadhbh Á. Brennan,Julien de Lima,Régis Brion,Annie Adraitet al. Scientific Reports, 2021, 11 (1), pp.12144. ⟨10.1038/s41598-021-91258-4⟩ Article dans une revue hal-04703070v1
Osteonecrosis of the Femoral Head Safely Healed with Autologous, Expanded, Bone Marrow-Derived Mesenchymal Stromal Cells in a Multicentric Trial with Minimum 5 Years Follow-Up Enrique Gómez-Barrena,Norma Padilla-Eguiluz,Philippe Rosset,Philippe Hernigou,Nicola Baldiniet al. Journal of Clinical Medicine, 2021, 10 (3), pp.508. ⟨10.3390/jcm10030508⟩ Article dans une revue hal-04699836v1
PPAR Gamma and Viral Infections of the Brain Pierre Layrolle,Pierre Payoux,Stéphane Chavanas International Journal of Molecular Sciences, 2021, 22 (16), pp.8876. ⟨10.3390/ijms22168876⟩ Article dans une revue hal-04693529v1
Evaluation of the Chemotherapy Drug Response Using Organotypic Cultures of Osteosarcoma Tumours from Mice Models and Canine Patients Bénédicte Brulin,John C Nolan,Tecla Marangon,Milan Kovacevic,Mathias Chatelaiset al. Cancers, 2021, 13 (19), pp.4890. ⟨10.3390/cancers13194890⟩ Article dans une revue hal-04693150v1
Biomimetic versus sintered macroporous calcium phosphate scaffolds enhanced bone regeneration and human mesenchymal stromal cell engraftment in calvarial defects Meadhbh Á. Brennan,David Monahan,Bénédicte Brulin,Sara Gallinetti,Paul Humbertet al. Acta Biomaterialia, 2021, 135, pp.689-704. ⟨10.1016/j.actbio.2021.09.007⟩ Article dans une revue hal-04685957v1
A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect Fiona Freeman,Meadhbh Á Brennan,David Browe,Audrey Renaud,Julien de Limaet al. Frontiers in Bioengineering and Biotechnology, 2020, 8, pp.230. ⟨10.3389/fbioe.2020.00230⟩ Article dans une revue hal-04703108v1
Regeneration of segmental defects in metatarsus of sheep with vascularized and customized 3D-printed calcium phosphate scaffolds Luciano Vidal,Carina Kampleitner,Stéphanie Krissian,Meadhbh A Brennan,Oskar Hoffmannet al. Scientific Reports, 2020, 10 (1), pp.7068. ⟨10.1038/s41598-020-63742-w⟩ Article dans une revue inserm-02873399v1
Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing Luciano Vidal,Carina Kampleitner,Meadhbh A Brennan,Alain Hoornaert,Pierre Layrolle Frontiers in Bioengineering and Biotechnology, 2020, 8, pp.61. ⟨10.3389/fbioe.2020.00061⟩ Article dans une revue inserm-02880917v1
Early efficacy evaluation of mesenchymal stromal cells (MSC) combined to biomaterials to treat long bone non-unions Enrique Gómez-Barrena,Norma Padilla-Eguiluz,Philippe Rosset,Florian Gebhard,Philippe Hernigouet al. Injury, 2020, 51, pp.S63-S73. ⟨10.1016/j.injury.2020.02.070⟩ Article dans une revue hal-04703112v1
Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration Meadhbh Á Brennan,Pierre Layrolle,David Mooney Advanced Functional Materials, 2020, 30 (37), ⟨10.1002/adfm.201909125⟩ Article dans une revue hal-04703094v1
Cold Plasma-Treated Ringer’s Saline: A Weapon to Target Osteosarcoma Miguel Mateu-Sanz,Juan Tornín,Bénédicte Brulin,Anna Khlyustova,Maria-Pau Ginebraet al. Cancers, 2020, 12 (1), pp.227. ⟨10.3390/cancers12010227⟩ Article dans une revue hal-04703122v1
Biomarkers of bone healing induced by a regenerative approach based on expanded bone marrow–derived mesenchymal stromal cells Donatella Granchi,Gabriela Ciapetti,Enrique Gómez-Barrena,Markus Rojewski,Philippe Rossetet al. Cytotherapy, 2019, 21 (8), pp.870-885. ⟨10.1016/j.jcyt.2019.06.002⟩ Article dans une revue istex hal-04703132v1
Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration Paul Humbert,Meadhbh A Brennan,Noel Davison,Philippe Rosset,Valérie Trichetet al. Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.00663⟩ Article dans une revue inserm-02148414v1
Vertical Bone Regeneration with Synthetic Biomimetic Calcium Phosphate onto the Calvaria of Rats Alain Hoornaert,Yassine Maazouz,David Pastorino,Carlos Aparicio,Gonzague de Pinieuxet al. Tissue Engineering Part C: Methods, 2019, 25 (1), pp.1-11. ⟨10.1089/ten.tec.2018.0260⟩ Article dans une revue hal-02103189v1
Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration Mariano Sanz,Christer Dahlin,Danae Apatzidou,Zvi Artzi,Darko Bozicet al. Journal of Clinical Periodontology, 2019, 46 (S21), pp.82-91. ⟨10.1111/jcpe.13123⟩ Article dans une revue hal-04703135v1
Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data Markus Thomas Rojewski,Ramin Lotfi,Cecilie Gjerde,Kamal Mustafa,Elena Veronesiet al. Cytotherapy, 2019, 21 (4), pp.468-482. ⟨10.1016/j.jcyt.2019.03.001⟩ Article dans une revue hal-04703145v1
Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells Salwa Suliman,Hassan Ali,Tommy Karlsen,Jerome Amiaud,Samih Mohamed-Ahmedet al. Scientific Reports, 2019, 9 (1), pp.16031. ⟨10.1038/s41598-019-52442-9⟩ Article dans une revue hal-04703127v1
Nanostructured surface coatings for titanium alloy implants Guy Louarn,Laëtitia Salou,Alain Hoornaert,Pierre Layrolle Journal of Materials Research, 2019, 34 (11), pp.1892-1899. ⟨10.1557/jmr.2019.39⟩ Article dans une revue hal-02271143v1
Early fracture healing is delayed in the Col1a2+/G610C osteogenesis imperfecta murine model Besio Roberta,Sylvia Maruelli,Séverine Battaglia,Laura Leoni,Simona Villaniet al. Calcified Tissue International, 2018, Epub ahead of print. ⟨10.1007/s00223-018-0461-x⟩ Article dans une revue inserm-01859541v1
Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial Cecilie Gjerde,Kamal Mustafa,Sølve Hellem,Markus Rojewski,Harald Gjengedalet al. Current Stem Cell Research & Therapy, 2018, 9 (1), pp.213. ⟨10.1186/s13287-018-0951-9⟩ Article dans une revue inserm-01859562v1
Feasibility and safety of treating non-unions in tibia, femur and humerus with autologous, expanded, bone marrow-derived mesenchymal stromal cells associated with biphasic calcium phosphate biomaterials in a multicentric, non-comparative trial Enrique Gomez-Barrena,Philippe Rosset,Florian Gebhard,Philippe Hernigou,Nicola Baldiniet al. Biomaterials, 2018, epub ahead of print. ⟨10.1016/j.biomaterials.2018.03.033⟩ Article dans une revue inserm-01782929v1
Comparison of Tumor- and Bone Marrow-Derived Mesenchymal Stromal/Stem Cells from Patients with High-Grade Osteosarcoma Louis-Romée Le Nail,Meadhbh A Brennan,Philippe Rosset,Frédéric Deschaseaux,Philippe Piloquetet al. International Journal of Molecular Sciences, 2018, 19 (3), pp.707. ⟨10.3390/ijms19030707⟩ Article dans une revue inserm-01724638v1
Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells Fiona E Freeman,Jessica Schiavi,Meadhbh A Brennan,Peter Owens,Pierre Layrolleet al. Tissue Engineering: Parts A, B, and C, 2017, 23 (23-24), pp.1466 - 1478. ⟨10.1089/ten.tea.2017.0052⟩ Article dans une revue inserm-01671244v1
IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro. Marie-Astrid Boutet,Aurelie Najm,Géraldine Bart,Régis Brion,Sophie Touchaiset al. Annals of the Rheumatic Diseases, 2017, 76 (7), pp.1304-1312. ⟨10.1136/annrheumdis-2016-210630⟩ Article dans une revue inserm-01671438v1
Inferior In Vivo Osteogenesis and Superior Angiogeneis of Human Adipose Tissue: A Comparison with Bone Marrow-Derived Stromal Stem Cells Cultured in Xeno-Free Conditions Meadhbh A Brennan,Audrey Renaud,Fabien Guilloton,Miryam Mebarki,Valérie Trichetet al. Stem Cells Translational Medicine, 2017, 6 (12), pp.2160 - 2172. ⟨10.1002/sctm.17-0133⟩ Article dans une revue inserm-01668944v1
Enhanced human bone marrow mesenchymal stromal cell adhesion on scaffolds promotes cell survival and bone formation. Miryam Mebarki,Laura Coquelin,Pierre Layrolle,Séverine Battaglia,Marine Tossouet al. Acta Biomaterialia, 2017, 59, pp.94-107. ⟨10.1016/j.actbio.2017.06.018⟩ Article dans une revue hal-01577907v1
Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach Donatella Granchi,Enrique Gómez-Barrena,Markus Rojewski,Philippe Rosset,Pierre Layrolleet al. Stem Cells International, 2017, 2017, Epub ahead of print. ⟨10.1155/2017/3674045⟩ Article dans une revue inserm-01671301v1
Biocompatibility, resorption and biofunctionality of a new synthetic biodegradable membrane for guided bone regeneration Alain Hoornaert,Cyril D’arros,Marie-Françoise Heymann,Pierre Layrolle Biomedical Materials, 2016, 11 (4), pp.045012. ⟨10.1088/1748-6041/11/4/045012⟩ Article dans une revue inserm-01702004v1
Bone regeneration strategies with bone marrow stromal cells in orthopaedic surgery Julien Stanovici,Louis Romée Le Nail,Luciano Vidal,Meadhbh A Brennan,Valérie Trichetet al. Current Research in Translational Medicine, 2016, 64 (2), pp.83 - 90. ⟨10.1016/j.retram.2016.04.006⟩ Article dans une revue inserm-01702061v1
Comparative bone tissue integration of nanostructured and microroughened dental implants Laëtitia Salou,Alain Hoornaert,Julien Stanovici,Sylvain Briand,Guy Louarnet al. Nanomedicine, 2015, 10 (5), pp.741 - 751. ⟨10.2217/NNM.14.223⟩ Article dans une revue inserm-01793585v1
Enhanced osseointegration of titanium implants with nanostructured surfaces: An experimental study in rabbits Laëtitia Salou,Alain Hoornaert,Guy Louarn,Pierre Layrolle Acta Biomaterialia, 2015, 11, pp.494 - 502. ⟨10.1016/j.actbio.2014.10.017⟩ Article dans une revue inserm-01793581v1
Controlled implant/soft tissue interaction by nanoscale surface modifications of 3D porous titanium implants Elisabeth Rieger,Agnès Dupret-Bories,Laetitia Salou,Marie-Hélène Metz-Boutigue,Pierre Layrolleet al. Nanoscale, 2015, 7 (21), pp.9908 - 9918. ⟨10.1039/c5nr01237f⟩ Article dans une revue inserm-01793588v1
Osteoblastic differentiation and potent osteogenicity of three-dimensional hBMSC-BCP particle constructs Thomas Cordonnier,Alain Langonné,Pierre Corre,Audrey Renaud,Luc Sensebeet al. Journal of Tissue Engineering and Regenerative Medicine, 2014, 8 (5), pp.364-76. ⟨10.1002/term.1529⟩ Article dans une revue istex inserm-01847272v1
EFFECTS OF A NOVEL CERAMIC BIOMATERIAL ON IMMUNE MODULATORY PROPERTIES AND DIFFERENTIATION POTENTIAL OF MESENCHYMAL STROMAL CELLS Giulio Bassi,Fabien Guilloton,Cédric Ménard,Mariano Di Trapani,Luciano Pacelliet al. Cytotherapy, 2014, 16 (4), pp.S90-S91. ⟨10.1016/j.jcyt.2014.01.336⟩ Article dans une revue istex hal-00988244v1
Pre-clinical studies of bone regeneration with human bone marrow stromal cells and biphasic calcium phosphate. Meadhbh Á Brennan,Audrey Renaud,Jérôme Amiaud,Markus T Rojewski,Hubert Schrezenmeieret al. Current Stem Cell Research & Therapy, 2013, 5 (5), pp.114. ⟨10.1186/scrt504⟩ Article dans une revue inserm-01205389v1
Computational model combined with in vitro experiments to analyse mechanotransduction during mesenchymal stem cell adhesion Jean-Louis Milan,Sandrine Lavenus,Paul Pilet,Guy Louarn,Sylvie Wendlinget al. eCells and Materials Journal, 2013, 25, pp.97-113. ⟨10.22203/eCM.v025a07⟩ Article dans une revue hal-02284008v1
Healing of long-bone defects in sheep metatarsals using bioceramics and mesenchymal stem cells Thomas Cordonnier,Jérôme Sohier,Luc Sensebé,Pierre Layrolle,Philippe Rosset Current Orthopaedic Practice, 2012, 23 (4), pp.369-376. ⟨10.1097/BCO.0b013e318259e847⟩ Article dans une revue hal-02373941v1
Consistent Osteoblastic Differentiation of Human Mesenchymal Stem Cells with Bone Morphogenetic Protein 4 and Low Serum Thomas Cordonnier,Alain Langonné,Jérôme Sohier,Pierre Layrolle,Philippe Rossetet al. Tissue Engineering Part C: Methods, 2011, 17 (3), pp.249-259. ⟨10.1089/ten.tec.2010.0387⟩ Article dans une revue hal-02373947v1
Bone Regeneration Using Porous Titanium Particles versus Bovine Hydroxyapatite: A Sinus Lift Study in Rabbits France Lambert,Geoffrey Lecloux,Angelique Léonard,Sophie Sourice,Pierre Layrolleet al. Clinical Implant Dentistry and Related Research, 2011, 15 (3), pp.412-426. ⟨10.1111/j.1708-8208.2011.00374.x⟩ Article dans une revue istex hal-05261845v1
Biomimetic Materials for Bone Tissue Engineering - State of the Art and Future Trends Thomas Cordonnier,Jérôme Sohier,Philippe Rosset,Pierre Layrolle Advanced Engineering Materials, 2011, 13 (5), pp.B135-B150. ⟨10.1002/adem.201080098⟩ Article dans une revue istex hal-02373943v1
Porous beta tricalcium phosphate scaffolds used as a BMP-2 delivery system for bone tissue engineering Jérôme Sohier,Guy Daculsi,Sophie Sourice,Klaas de Groot,Pierre Layrolle Journal of Biomedical Materials Research Part A, 2009, 9999A, pp.NA-NA. ⟨10.1002/jbm.a.32467⟩ Article dans une revue istex hal-02373949v1
Rapid prototyped porous titanium coated with calcium phosphate as a scaffold for bone tissue engineering Marco Lopez-Heredia,Jérôme Sohier,Cédric Gaillard,Sophie Quillard,Michel Dorgetet al. Biomaterials, 2008, 29 (17), pp.2608-2615. ⟨10.1016/j.biomaterials.2008.02.021⟩ Article dans une revue istex hal-02373967v1
Bone repair using a new injectable self-crosslinkable bone substitute. Borhane H. Fellah,Pierre Weiss,Olivier Gauthier,Thierry Rouillon,Paul Piletet al. Journal of Orthopaedic Research, 2006, 24 (4), pp.628-35. ⟨10.1002/jor.20125⟩ Article dans une revue inserm-00170238v1

Communication dans un congrès (2)

Evaluation of trabecular bone patterns on dental radiographic images: influence of cortical bone Yves Amouriq,Pierre Evenou,Aurore Arlicot,Nicolas Normand,Pierre Layrolleet al. SPIE Medical Imaging, Feb 2010, San Diego, United States. pp.76261M, ⟨10.1117/12.843964⟩ Communication dans un congrès hal-00471803v1
Evaluation of trabecular bone patterns on dental radiographic images: inﬂuence of cortical bone Yves Amouriq,Pierre Evenou,Aurore Arlicot,Nicolas Normand,Pierre Layrolleet al. SPIE Medical Imaging, Feb 2010, United States. 10 p Communication dans un congrès hal-00614771v2