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Lionel Mourey

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Lionel MOUREY – CURRICULUM VITAE – Aug. 2022 Family name: MOUREY Given name: Lionel Nationality: French Date of birth: 5 August 1961 Place of birth: Vesoul, France Current position: CNRS senior researcher (DR1) – Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS – Université Toulouse 3 Address: IPBS, 205 route de Narbonne, BP 64182, 31077 Toulouse, France Tel: (33) 5 61 17 54 36, Fax: (33) 5 61 17 59 94 Email: Lionel.Mourey@ipbs.fr **EDUCATION** ------------- \- 2002: Habilitation à Diriger des Recherches (HDR), University of Toulouse \- 1991: PhD from the University of Strasbourg, Dr. D. Moras, Institut de Biologie Moléculaire et Cellulaire (IBMC), Strasbourg, France- \- 1988: DEA (master’s degree) of biological crystallography, University of Strasbourg \- 1984–1987: Engineer diploma, Ecole Nationale Supérieure de Chimie, Strasbourg **PROFESSIONNAL APPOINTMENTS** ------------------------------ \- 2009–2014: Joint director of the Structural Biology and Biophysics department, IPBS, Toulouse \- 2006–2014: Scientific supervisor of the Integrated Screening Platform of Toulouse (PICT) \- Since 2005: CNRS senior researcher \- Since 2002: Head of the structural biophysics team and of the biophysics and macromolecular crystallographic facility, IPBS, Toulouse \- 1992–2001: CNRS researcher, Laboratory of Crystallography, Dr. J.-P. Samama, IPBS, Toulouse \- 1991–1992: Post-doctoral fellow of Dr. D. Moras, IBMC, Strasbourg **KEYWORDS** ------------ Biochemistry; biophysics; integrative structural biology; biocrystallography; protein-ligand interactions; structure-based ligand screening and design; infectious diseases. **SYNOPSIS** ------------ I am senior research director at CNRS and head of the "Structural biophysics" team and of the biophysics and macromolecular crystallography facility at IPBS. I am cofounder of the Integrated Platform of Screening of Toulouse (PICT), a national facility on structural biology and ligand screening, IBiSA labelled platform, certified ISO 9001:2018 and NF X50-900. My main competences are in the field of biochemistry, biophysics and structural biology, including X-ray crystallography of biological macromolecules and their complexes with a special emphasis on infectious diseases. I have contributed to the publication of 89 original articles in international journals and to the determination of 116 structures deposited within the Protein Data Bank. **CITATION METRICS** -------------------- [https://scholar.google.com/citations?hl=fr&user=CriNGHMAAAAJ](https://scholar.google.com/citations?hl=fr&user=CriNGHMAAAAJ)

Publications

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The conserved yeast protein Knr4 involved in cell wall integrity is a multi-domain intrinsically disordered protein

Manon Batista , Ellen I.M. Donker , Cécile Bon , Myriam Guillien , Adriana Caisso
Journal of Molecular Biology, 2023, 435 (10), pp.168048. ⟨10.1016/j.jmb.2023.168048⟩
Journal articles hal-03874437v2
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Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA

Mélina Chebaiki , Evelyne Delfourne , Rasoul Tamhaev , Saïda Danoun , Frédéric Rodriguez
European Journal of Medicinal Chemistry, 2023, 259, pp.115646. ⟨10.1016/j.ejmech.2023.115646⟩
Journal articles hal-04244940v1
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Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli

Wladimir Malaga , Delphine Payros , Eva Meunier , Wafa Frigui , Fadel Sayes
PLoS Pathogens, 2023, 19 (7), pp.e1011437. ⟨10.1371/journal.ppat.1011437⟩
Journal articles hal-04163557v1
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Synthesis, characterization, anti-tuberculosis activity and molecular modeling studies of thiourea derivatives bearing aminoguanidine moiety

Michael Tapera , Hüseyin Kekeçmuhammed , Kader Sahin , Vagolu Siva Krishna , Christian Lherbet
Journal of Molecular Structure, 2022, 1270, pp.133899. ⟨10.1016/j.molstruc.2022.133899⟩
Journal articles hal-03797382v1
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Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis

Moise Mansour , Emmanuel Giudice , Xibing Xu , Hatice Akarsu , Patricia Bordes
Nature Communications, 2022, 13 (1), pp.2641. ⟨10.1038/s41467-022-30373-w⟩
Journal articles hal-03751990v1
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Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis

Nguyen-Hung Le , Patricia Constant , Samuel Tranier , Virginie Nahoum , Valérie Guillet
Bioorganic and Medicinal Chemistry Letters, 2022, 71, pp.116938. ⟨10.1016/j.bmc.2022.116938⟩
Journal articles hal-03758907v1
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Bioinformatic Mining and Structure-Activity Profiling of Baeyer-Villiger Monooxygenases from Mycobacterium tuberculosis

Nicolas Tomas , Dimitri Leonelli , Martin Campoy , Sylvain Marthey , Nguyen-Hung Le
MSphere, 2022, 7 (2), pp.00482-21. ⟨10.1128/msphere.00482-21⟩
Journal articles hal-03752165v1
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Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis

Cécile Bon , Stéphanie Cabantous , Sylviane Julien , Valérie Guillet , Christian Chalut
BMC Biology, 2022, 20, ⟨10.1186/s12915-022-01337-9⟩
Journal articles hal-03751987v1
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Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds

Coralie Carivenc , Laurent Maveyraud , Claire Blanger , Stéphanie Ballereau , Coralie Roy-Camille
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-97197-4⟩
Journal articles hal-03345048v1
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Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from Mycobacterium tuberculosis

Romain Galy , Stéphanie Ballereau , Yves Génisson , Lionel Mourey , Jean-Christophe Plaquevent
Pharmaceuticals, 2021, 14 (12), pp.1282. ⟨10.3390/ph14121282⟩
Journal articles hal-03683937v1
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Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases

Anna D Grabowska , Yoann Brison , Laurent Maveyraud , Sabine Gavalda , Alexandre Faille
ACS Chemical Biology, 2020, 15 (12), pp.3206 - 3216. ⟨10.1021/acschembio.0c00772⟩
Journal articles hal-03752170v2
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Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors

Jacques Augenstreich , Evert Haanappel , Fadel Sayes , Roxane Simeone , Valerie Guillet
Frontiers in Cellular and Infection Microbiology, 2020, 10, pp.420. ⟨10.3389/fcimb.2020.00420⟩
Journal articles pasteur-02873531v1
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Conformational flexibility of coenzyme A and its impact on the post‐translational modification of acyl carrier proteins by 4′‐phosphopantetheinyl transferases

Minh Chau Nguyen , Olivier Saurel , Coralie Carivenc , Sabine Gavalda , Stéphane Saitta
FEBS Journal, 2020, 287, pp.4729 - 4746. ⟨10.1111/febs.15273⟩
Journal articles hal-02950584v1
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Protein X-ray Crystallography and Drug Discovery

Laurent Maveyraud , Lionel Mourey
Molecules, 2020, 25 (5), pp.1030. ⟨10.3390/molecules25051030⟩
Journal articles hal-02950589v1
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Structural insights into chaperone addiction of toxin-antitoxin systems

Valerie Guillet , Patricia Bordes , Cécile Bon , Julien Marcoux , Virginie Gervais
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-08747-4⟩
Journal articles hal-02335509v1
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Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components

Luis F Garcia-Alles , Katharina Root , Laurent Maveyraud , Nathalie Aubry , Eric Lesniewska
PLoS ONE, 2019, 14 (10), pp.e0223877. ⟨10.1371/journal.pone.0223877⟩
Journal articles hal-03841381v1
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Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases

Alexandre Faille , Sabine Gavalda , Nawel Slama , Christian Lherbet , Laurent Maveyraud
Journal of Molecular Biology, 2017, 429 (47), pp.1554 - 1569. ⟨10.1016/j.jmb.2017.03.026⟩
Journal articles hal-03002100v1
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NMR secondary structure and interactions of recombinant human MOZART1 protein, a component of the gamma-tubulin complex

Cyprian D Cukier , Audrey Tourdes , Dounia El-Mazouni , Valérie Guillet , Julian Nomme
Protein Science, 2017, 26 (11), pp.2240 - 2248. ⟨10.1002/pro.3282⟩
Journal articles hal-03002130v1
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Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis.

Nguyen-Hung Le , Virginie Molle , Nathalie Eynard , Mathieu Miras , Alexandre Stella
Journal of Biological Chemistry, 2016, 291 (43), pp.22793-22805. ⟨10.1074/jbc.M116.748053⟩
Journal articles hal-01604694v1
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Chaperone addiction of toxin–antitoxin systems

Patricia Bordes , Ambre Julie Sala , Sara Ayala , Pauline Texier , Nawel Slama
Nature Communications, 2016, 7, pp.13339. ⟨10.1038/ncomms13339⟩
Journal articles hal-03002198v1
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Structural Insights into the Carbohydrate Binding Ability of an α-(1→2) Branching Sucrase from Glycoside Hydrolase Family 70

Yoann Brison , Yannick Malbert , Georges Czaplicki , Lionel Mourey , Magali Remaud-Simeon
Journal of Biological Chemistry, 2016, 291 (14), pp.7527-7540. ⟨10.1074/jbc.M115.688796⟩
Journal articles hal-03002155v1
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Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria

Valérie Guillet , Ségolène Galandrin , Laurent Maveyraud , Simon Ladevèze , Vincent Mariaule
Journal of Biological Chemistry, 2016, 291 (15), pp.7973-7989. ⟨10.1074/jbc.M115.712612⟩
Journal articles hal-03002148v1
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Natural disease history and characterisation of SUMF1 molecular defects in ten unrelated patients with multiple sulfatase deficiency

Frédérique Sabourdy , Lionel Mourey , Emmanuelle Le Trionnaire , Nathalie Bednarek , Catherine Caillaud
Orphanet Journal of Rare Diseases, 2015, 10, pp.31. ⟨10.1186/s13023-015-0244-7⟩
Journal articles hal-03002953v1
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Structural bases for N-glycan processing by mannoside phosphorylase

Simon Ladeveze , Gianluca Cioci , Pierre Roblin , Lionel Mourey , Samuel Tranier
Acta crystallographica Section D : Structural biology [1993-..], 2015, 71 (Part 6), pp.1335-46. ⟨10.1107/S1399004715006604⟩
Journal articles hal-01183896v1
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Crystallographic studies of the structured core domain of Knr4 fromSaccharomyces cerevisiae

Sylviane Julien , Patrick Tondl , Fabien Durand , Adilia Dagkessamanskaia , Herman van Tilbeurgh
Acta crystallographica Section F : Structural biology communications [2014-..], 2015, 71 (9), pp.1120 - 1124. ⟨10.1107/s2053230x15012522⟩
Journal articles hal-03002962v1
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Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach

Aurélien Chollet , Lionel Mourey , Christian Lherbet , Alexandra Delbot , Sylviane Julien
Journal of Structural Biology, 2015, 190, pp.328 - 337. ⟨10.1016/j.jsb.2015.04.008⟩
Journal articles hal-03002973v1
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Phosphorylation of KasB Regulates Virulence and Acid-Fastness in Mycobacterium tuberculosis

Catherine Vilchèze , Virginie Molle , Severine Carrere-Kremer , Jade Leiba , Lionel Mourey
PLoS Pathogens, 2014, 10 (5), pp.e1004115. ⟨10.1371/journal.ppat.1004115⟩
Journal articles hal-02282645v1
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First Structural Insights into α-l-Arabinofuranosidases from the Two GH62 Glycoside Hydrolase Subfamilies

Béatrice Siguier , Mireille Haon , Virginie Nahoum , Marlène Marcellin , Odile Burlet-Schiltz
Journal of Biological Chemistry, 2014, 289 (8), pp.5261-5273. ⟨10.1074/jbc.M113.528133⟩
Journal articles hal-02419708v1
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The Polyketide Synthase Pks13 Catalyzes a Novel Mechanism of Lipid Transfer in Mycobacteria

Sabine Gavalda , Fabienne Bardou , Françoise Laval , Cécile Bon , Wladimir Malaga
Chemistry and Biology, 2014, 21 (12), pp.1660 - 1669. ⟨10.1016/j.chembiol.2014.10.011⟩
Journal articles hal-03002982v1
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New Insights on the Mechanism of Quinoline-based DNA Methyltransferase Inhibitors

Christina Gros , Laurence Fleury , Virginie Nahoum , Céline Faux , Sergio Valente
Journal of Biological Chemistry, 2014, 290, pp.6293 - 6302. ⟨10.1074/jbc.m114.594671⟩
Journal articles hal-03002969v1
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Residues Essential for Panton-Valentine Leukocidin S Component Binding to Its Cell Receptor Suggest Both Plasticity and Adaptability in Its Interaction Surface

Benoit-Joseph Laventie , Frédéric Guerin , Lionel Mourey , Mira y Tawk , Emmanuel Jover
PLoS ONE, 2014, 9 (3), pp.e92094. ⟨10.1371/journal.pone.0092094⟩
Journal articles hal-03002978v1
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Assay Development for Identifying Inhibitors of the Mycobacterial FadD32 Activity

Ségolène Galandrin , Valérie Guillet , Rajendra S Rane , Mathieu Léger , N. Radha
Journal of Biomolecular Screening, 2013, 18 (5), pp.576-587. ⟨10.1177/1087057112474691⟩
Journal articles hal-03003002v1
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Detection of soluble co-factor dependent protein expression in vivo : Application to the 4′-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis

Karine Rottier , Alexandre Faille , Thomas Prudhomme , Cécile Leblanc , Christian Chalut
Journal of Structural Biology, 2013, 183 (3), pp.320 - 328. ⟨10.1016/j.jsb.2013.07.010⟩
Journal articles hal-03002994v1
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Virtual and Biophysical Screening Targeting the γ-Tubulin Complex – A New Target for the Inhibition of Microtubule Nucleation

Olivier Cala , Marie-Hélène Remy , Valérie Guillet , Andreas Merdes , Lionel Mourey
PLoS ONE, 2013, 8 (5), pp.e63908. ⟨10.1371/journal.pone.0063908⟩
Journal articles hal-03003005v1

Crystallization and preliminary crystallographic studies of both components of the staphylococcal LukE–LukD leukotoxin

Romain Galy , Fabien Bergeret , Daniel Keller , Lionel Mourey , Gilles Prévost
Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2012, 68, pp.663 - 667. ⟨10.1107/s1744309112014662⟩
Journal articles hal-03003049v1
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Applying Pairwise Combinations of Amino Acid Mutations for Sorting Out Highly Efficient Glucosylation Tools for Chemo-Enzymatic Synthesis of Bacterial Oligosaccharides

Elise Champion , Frédéric Guerin , Claire Moulis , Sophie Barbe , Thu Hoai Tran
Journal of the American Chemical Society, 2012, 134 (45), pp.18677 - 18688. ⟨10.1021/ja306845b⟩
Journal articles hal-03003058v1
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Phosphorylation of Mycobacterial PcaA Inhibits Mycolic Acid Cyclopropanation

Rosa Milagros Corrales , Virginie Molle , Jade Leiba , Lionel Mourey , Chantal de Chastellier
Journal of Biological Chemistry, 2012, 287 (31), pp.26187 - 26199. ⟨10.1074/jbc.m112.373209⟩
Journal articles hal-03003056v1
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Biochemical and Structural Study of the Atypical Acyltransferase Domain from the Mycobacterial Polyketide Synthase Pks13

Fabien Bergeret , Sabine Gavalda , Christian Chalut , Wladimir Malaga , Annaïk Quémard
Journal of Biological Chemistry, 2012, 287, pp.33675 - 33690. ⟨10.1074/jbc.m111.325639⟩
Journal articles hal-03003064v1
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Functional and Structural Characterization of alpha-(1 -> 2) Branching Sucrase Derived from DSR-E Glucansucrase

Yoann Brison , Tjaard Pijning , Yannick Malbert , Emeline Fabre , Lionel Mourey
Journal of Biological Chemistry, 2012, 287 (11), pp.7915 - 7924. ⟨10.1074/jbc.M111.305078⟩
Journal articles hal-01268398v1
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Structural Investigation of the Thermostability and Product Specificity of Amylosucrase from the Bacterium Deinococcus geothermalis

Frédéric Guerin , Sophie Barbe , Sandra Serin , Gabrielle Veronese , David Guieysse
Journal of Biological Chemistry, 2012, 287 (9), pp.6642 - 6654. ⟨10.1074/jbc.M111.322917⟩
Journal articles hal-01268407v1
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Functional and Structural Characterization of α-(1→2) Branching Sucrase Derived from DSR-E Glucansucrase

Yoann Brison , Tjaard Pijning , Yannick Malbert , Émeline Fabre , Lionel Mourey
Journal of Biological Chemistry, 2012, 287, pp.7915 - 7924. ⟨10.1074/jbc.m111.305078⟩
Journal articles hal-03003060v1

Microtubule nucleation by γ-tubulin complexes

Justin M Kollman , Andreas Merdes , Lionel Mourey , David A Agard
Nature Reviews Molecular Cell Biology, 2011, 12, pp.709 - 721. ⟨10.1038/nrm3209⟩
Journal articles hal-03003365v1
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Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes

Luis Garcia-Alles , Gaelle Giacometti , Cees Versluis , Laurent Maveyraud , Diane de Paepe
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (32), pp.13230 - 13235. ⟨10.1073/pnas.1105627108⟩
Journal articles hal-03003375v1
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Structural Investigation of the Thermostability and Product Specificity of Amylosucrase from the BacteriumDeinococcus geothermalis

Frédéric Guerin , Sophie Barbe , Sandra Pizzut-Serin , Gabrielle Potocki-Veronese , David Guieysse
Journal of Biological Chemistry, 2011, 287, pp.6642 - 6654. ⟨10.1074/jbc.m111.322917⟩
Journal articles hal-03003044v1

Crystal structure of γ-tubulin complex protein GCP4 provides insight into microtubule nucleation

Valérie Guillet , Martine Knibiehler , Lynn Gregory-Pauron , Marie-Hélène Remy , Cécile Chemin
Nature Structural and Molecular Biology, 2011, 18, pp.915 - 919. ⟨10.1038/nsmb.2083⟩
Journal articles hal-03003370v1
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Experimental mapping of soluble protein domains using a hierarchical approach

Jean-Denis Pedelacq , Hau B Nguyen , Stephanie Cabantous , Brian L Mark , Pawel Listwan
Nucleic Acids Research, 2011, 39, pp.e125 - e125. ⟨10.1093/nar/gkr548⟩
Journal articles hal-03003363v1

Exploring the Conformational States and Rearrangements of Yarrowia lipolytica Lipase

Florence Bordes , Sophie Barbe , Pierre Escalier , Lionel Mourey , Isabelle André
Biophysical Journal, 2010, 99 (7), pp.2225 - 2234. ⟨10.1016/j.bpj.2010.07.040⟩
Journal articles hal-02667777v1

Fatty Acyl Structures of Mycobacterium tuberculosis Sulfoglycolipid Govern T Cell Response

Julie Guiard , Anthony Collmann , Luis Garcia-Alles , Lionel Mourey , Thérèse Brando
Journal of Immunology, 2009, 182 (11), pp.7030 - 7037. ⟨10.4049/jimmunol.0804044⟩
Journal articles hal-03003394v1
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S-Adenosyl-N-decyl-aminoethyl, a Potent Bisubstrate Inhibitor ofMycobacterium tuberculosisMycolic Acid Methyltransferases

Julien Vaubourgeix , Fabienne Bardou , Fanny Boissier , Sylviane Julien , Patricia Constant
Journal of Biological Chemistry, 2009, 284, pp.19321 - 19330. ⟨10.1074/jbc.m809599200⟩
Journal articles hal-03003382v1
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The Dual Function of the Mycobacterium tuberculosis FadD32 Required for Mycolic Acid Biosynthesis

Mathieu Léger , Sabine Gavalda , Valérie Guillet , Benoît van Der Rest , Nawel Slama
Chemistry and Biology, 2009, 16, pp.510 - 519. ⟨10.1016/j.chembiol.2009.03.012⟩
Journal articles hal-03003389v1
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Structural basis for sugar recognition, including the Tn carcinoma antigen, by the lectin SNA-II from Sambucus nigra

Laurent Maveyraud , Hideaki Niwa , Valérie Guillet , Dmitri I Svergun , Peter V Konarev
Proteins - Structure, Function and Bioinformatics, 2008, 75, pp.89 - 103. ⟨10.1002/prot.22222⟩
Journal articles hal-03003386v1
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A covalent S-F heterodimer of leucotoxin reveals molecular plasticity of β-barrel pore-forming toxins

Pierre Roblin , Valérie Guillet , Olivier R. Joubert , Daniel Keller , Monique Erard
Proteins - Structure, Function and Bioinformatics, 2008, 71, pp.485 - 496. ⟨10.1002/prot.21900⟩
Journal articles hal-03003397v1
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Structure-Function Analysis of the THAP Zinc Finger of THAP1, a Large C2CH DNA-binding Module Linked to Rb/E2F Pathways

Damien Bessière , Chrystelle Lacroix , Sébastien Campagne , Vincent Ecochard , Valérie Guillet
Journal of Biological Chemistry, 2008, 283, pp.4352 - 4363. ⟨10.1074/jbc.m707537200⟩
Journal articles hal-03003405v1
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Distinction between Pore Assembly by Staphylococcal α-Toxin versus Leukotoxins

Olivier R. Joubert , Joëlle Voegelin , Valérie Guillet , Samuel Tranier , Sandra Werner
Journal of Biomedicine and Biotechnology, 2007, 2007, pp.025935. ⟨10.1155/2007/25935⟩
Journal articles hal-03003420v1
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Fine-tuning of intrinsic N-Oct-3 POU domain allostery by regulatory DNA targets

Robert Alazard , Lionel Mourey , Christine Ebel , Peter V Konarev , Maxim V Petoukhov
Nucleic Acids Research, 2007, 35, pp.4420 - 4432. ⟨10.1093/nar/gkm453⟩
Journal articles hal-03003424v1
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Engineered covalent leucotoxin heterodimers form functional pores: insights into S–F interactions

Olivier R. Joubert , Gabriella Viero , Daniel Keller , Eric Martinez , Didier A Colin
Biochemical Journal, 2006, 396 (2), pp.381 - 389. ⟨10.1042/bj20051878⟩
Journal articles hal-03003436v1

Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b

Luis Garcia-Alles , Kees Versluis , Laurent Maveyraud , Ana Tesouro Vallina , Sebastiano Sansano
EMBO Journal, 2006, 25 (15), pp.3684 - 3692. ⟨10.1038/sj.emboj.7601244⟩
Journal articles hal-03003440v1
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Further Insight into S-Adenosylmethionine-dependent Methyltransferases: STRUCTURAL CHARACTERIZATION OF Hma, AN ENZYME ESSENTIAL FOR THE BIOSYNTHESIS OF OXYGENATED MYCOLIC ACIDS IN MYCOBACTERIUM TUBERCULOSIS

Fanny Boissier , Fabienne Bardou , Valérie Guillet , Sandrine Uttenweiler-Joseph , Mamadou Daffé
Journal of Biological Chemistry, 2006, 281 (7), pp.4434-4445. ⟨10.1074/jbc.M510250200⟩
Journal articles hal-03003456v1

Assistance of Microbial Glycolipid Antigen Processing by CD1e

Henri de La Salle , Sabrina Mariotti , Catherine Angénieux , Martine Gilleron , Luis Fernando Garcia-Alles
Science, 2005, 310 (5752), pp.1321-1324. ⟨10.1126/science.1115301⟩
Journal articles hal-03003514v1
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Crystal Structure of Leucotoxin S Component

Valérie Guillet , Pierre Roblin , Sandra Werner , Manuela Coraiola , Gianfranco Menestrina
Journal of Biological Chemistry, 2004, 279, pp.41028 - 41037. ⟨10.1074/jbc.m406904200⟩
Journal articles hal-03004162v1
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The Membrane-associated Form of the DNA Repair Protein Ku is Involved in Cell Adhesion to Fibronectin

Sylvie Monferran , Catherine Muller , Lionel Mourey , Philippe Frit , Bernard Salles
Journal of Molecular Biology, 2004, 337, pp.503 - 511. ⟨10.1016/j.jmb.2004.01.057⟩
Journal articles hal-03004153v1

Crystallization and preliminary crystallographic data of a leucotoxin S component from Staphylococcus aureus

Valérie Ârie Guillet , Daniel Keller , Gilles Prévost , Lionel Mourey
Acta crystallographica Section D : Structural biology [1993-..], 2004, 60, pp.310 - 313. ⟨10.1107/s090744490302910x⟩
Journal articles hal-03004171v1
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Protein-protein interactions within the Fatty Acid Synthase-II system of Mycobacterium tuberculosis are essential for mycobacterial viability

Romain Veyron-Churlet , Olivier Guerrini , Lionel Mourey , Mamadou Daffé , Didier Zerbib
Molecular Microbiology, 2004, 54 (5), pp.1161-1172. ⟨10.1111/j.1365-2958.2004.04334.x⟩
Journal articles hal-03004144v1
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The molecular puzzle of two-component signaling cascades

Marie Foussard , Stéphanie Cabantous , Jean-Denis Pedelacq , Valérie Guillet , Samuel Tranier
Microbes and Infection, 2001, 3 (5), pp.417-424. ⟨10.1016/s1286-4579(01)01390-9⟩
Journal articles hal-03004328v1
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Crystal Structure of the CheA Histidine Phosphotransfer Domain that Mediates Response Regulator Phosphorylation in Bacterial Chemotaxis

Lionel Mourey , Sandra da Re , Jean-Denis Pedelacq , Tatiana Tolstykh , Cécile Faurie
Journal of Biological Chemistry, 2001, 276, pp.31074 - 31082. ⟨10.1074/jbc.m101943200⟩
Journal articles hal-03004208v1
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Crystal structure of the F component of the Panton-Valentine leucocidin

Jean-Denis Pedelacq , Gilles Prevost , Henri Monteil , Lionel Mourey , Jean-Pierre Samama
J. Med. Microbial, 2000, 290, pp.395 - 401
Journal articles hal-03004342v1

6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of .BETA.-Lactamases.

Dasantila Golemi , Laurent Maveyraud , Akihiro Ishiwata , Samuel Tramer , Kazuyuki Miyashita
Journal of Antibiotics, 2000, 53 (10), pp.1022-1027. ⟨10.7164/antibiotics.53.1022⟩
Journal articles hal-03004369v1
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The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins

Jean-Denis Pedelacq , Laurent Maveyraud , Gilles Prévost , Lamine Baba-Moussa , Ana González
Structure, 1999, 7 (3), pp.277-287. ⟨10.1016/s0969-2126(99)80038-0⟩
Journal articles hal-03004378v1
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Conformational changes induced by phosphorylation of the FixJ receiver domain

Catherine Birck , Lionel Mourey , Patrice Gouet , Béatrice Fabry , Jörg Schumacher
Structure, 1999, 7 (12), pp.1505-1515. ⟨10.1016/s0969-2126(00)88341-0⟩
Journal articles hal-03004414v1
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Structural transitions in the FixJ receiver domain

Patrice Gouet , Béatrice Fabry , Valérie Guillet , Catherine Birck , Lionel Mourey
Structure, 1999, 7 (12), pp.1517-1526. ⟨10.1016/S0969-2126(00)88342-2⟩
Journal articles hal-03004398v1
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Inhibition of the Broad Spectrum Nonmetallocarbapenamase of Class A (NMC-A) ␤-Lactamase from Enterobacter cloacae by Monocyclic ␤-Lactams* □ S

Lionel Mourey , Lakshmi P Kotra , John Bellettiniʈ , Alexey Bulychev , Michael O'Brien
Journal of Biological Chemistry, 1999, 274, pp.25260 - 25265
Journal articles hal-03004384v1
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Inhibition of the NMC-A β-Lactamase by a Penicillanic Acid Derivative and the Structural Bases for the Increase in Substrate Profile of This Antibiotic Resistance Enzyme

Lionel Mourey , Kazuyuki Miyashita , Peter Swarén , Alexey Bulychev , Jean-Pierre Samama
Journal of the American Chemical Society, 1998, 120 (36), pp.9382-9383. ⟨10.1021/ja9817996⟩
Journal articles hal-03004572v1
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X-ray Analysis of the NMC-A β-Lactamase at 1.64-Å Resolution, a Class A Carbapenemase with Broad Substrate Specificity

Peter Swarén , Laurent Maveyraud , Xavier Raquet , Stéphanie Cabantous , Colette Duez
Journal of Biological Chemistry, 1998, 273 (41), pp.26714-26721. ⟨10.1074/jbc.273.41.26714⟩
Journal articles hal-03004553v1

Structure of the CheY-binding domain of histidine kinase CheA in complex with CheY

Martin Welch , Natalie Chinardet , Lionel Mourey , Catherine Birck , Jean-Pierre Samama
Nature Structural Biology, 1998, 5 (1), pp.25-29. ⟨10.1038/nsb0198-25⟩
Journal articles hal-03004494v1
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Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A β-Lactamases from the Antibiotic-Resistant Bacteria

Laurent Maveyraud , Lionel Mourey , Lakshmi P Kotra , Jean-Denis Pedelacq , Valérie Guillet
Journal of the American Chemical Society, 1998, 120 (38), pp.9748-9752. ⟨10.1021/ja9818001⟩
Journal articles hal-03004592v1
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Crystal Structure of the Arcelin-1 Dimer from Phaseolus vulgaris at 1.9-Å Resolution

Lionel Mourey , Jean-Denis Pedelacq , Catherine Birck , Christine Fabre , Pierre Rougé
Journal of Biological Chemistry, 1998, 273 (21), pp.12914-12922. ⟨10.1074/jbc.273.21.12914⟩
Journal articles hal-03004563v1

Oligomeric structure of the repressor of the bacteriophage Mu early operon

Robert Alazard , Christine Ebel , Catherine Venien-Bryan , Lionel Mourey , Jean Pierre Samama
Eur J Biochem, 1998, 252 (3), pp.408 - 415. ⟨10.1046/j.1432-1327.1998.2520408.x⟩
Journal articles hal-03004629v1

Characterization and sugar-binding properties of arcelin-1, an insecticidal lectin-like protein isolated from kidney bean (Phaseolus vulgaris L. cv. RAZ-2) seeds

Christine Fabre , Henri Causse , Lionel Mourey , Jos Koninkx , Michel Rivière
Biochemical Journal, 1998, 329 (3), pp.551 - 560. ⟨10.1042/bj3290551⟩
Journal articles hal-03004605v1
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The structure of Staphylococcus aureus epidermolytic toxin A, an atypic serine protease, at 1.7 Å resolution

Jean Cavarelli , Gilles Prévost , William Bourguet , Luc Moulinier , Bernard Chevrier
Structure, 1997, 5 (6), pp.813-824. ⟨10.1016/s0969-2126(97)00235-9⟩
Journal articles hal-03004650v1
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Small-Angle x-ray scattering and crystallographic studies of arcelin-1: An insecticidal lectin-like glycoprotein fromPhaseolus vulgaris L

Lionel Mourey , Jean-Denis Pedelacq , Christine Fabre , Henri Causse , Pierre Rougé
Proteins: Structure, Function, and Genetics, 1997, 29 (4), pp.433-442. ⟨10.1002/(sici)1097-0134(199712)29:4<433::aid-prot4>3.0.co;2-9⟩
Journal articles hal-03004639v1
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Structural Basis of Extended Spectrum TEM ␤-Lactamases CRYSTALLOGRAPHIC, KINETIC, AND MASS SPECTROMETRIC INVESTIGATIONS OF ENZYME MUTANTS*

Laurent Maveyraud , Isabelle Saves , Odile Burlet-Schiltz , Peter Swarén , Jean-Michel Masson
Journal of Biological Chemistry, 1996, 271 (18), pp.10482-10489. ⟨10.1074/jbc.271.18.10482⟩
Journal articles hal-03004742v1
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Electrostatic analysis of TEM1 -lactamase: effect of substrate binding, steep potential gradients and consequences of site-directed mutations

Peter Swarén , Laurent Maveyraud , Valérie Guillet , Jean-Michel Masson , Lionel Mourey
Structure, 1995, 3 (6), pp.603-613. ⟨10.1016/s0969-2126(01)00194-0⟩
Journal articles hal-03004753v1
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Crystal Structure of Escherichia coZi TEMl P-Lactamase at 1.8 A Resolution

Christian Jelsch , Lionel Mourey , Jean-Michel Masson , Jean-Pierre Samama
Proteins: Structure, Function, and Genetics, 1993, 16 (4), pp.16364 - 383. ⟨10.1002/prot.340160406⟩
Journal articles hal-03004808v1
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Crystal Structure of Cleaved Bovine Antithrombin III at 3·2 Å Resolution

Lionel Mourey , Jean-Pierre Samama , Marc Delarue , Maurice Petitou , Jean Choay
Journal of Molecular Biology, 1993, 232 (1), pp.223-241. ⟨10.1006/jmbi.1993.1378⟩
Journal articles hal-03004796v1
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Selectivity in substitution chemistry of mixed-metal, tetrahedral MCo3 (M = iron, ruthenium) carbonyl clusters: cobalt-59 NMR study and crystal structure of RuCo3(.mu.3-H)(.mu.-CO)3(CO)8(NMe3)

Pierre Braunstein , Lionel Mourey , Jacky Rosé , Pierre Granger , Thierry Richert
Organometallics, 1992, 11 (7), pp.2628-2634. ⟨10.1021/om00043a054⟩
Journal articles hal-03004821v1