Lionel Nauton

Publications

Article dans une revue (50)

Interactions of insulin aspart hexamer and excipients with plasticized polyvinyl chloride surfaces: A comprehensive investigation combining molecular simulations and experiments Pierre Fayon,Philip Chennell,Mehdi Sahihi,Julien Devémy,Emmanuelle Feschetet al. International Journal of Biological Macromolecules, 2025, 319 (Pt 2), pp.145043. ⟨10.1016/j.ijbiomac.2025.145043⟩ Article dans une revue hal-05174554v1
Exploring the synthetic potential of dihydroxyacetone-aldolases from acidophilic organisms Léo Paulat,Cédric Gastaldi,Lionel Nauton,Mariline Theveniot,Muriel Jolyet al. Catalysis Science & Technology, 2024, 14 (17), pp.5107-5113. ⟨10.1039/D4CY00747F⟩ Article dans une revue cea-05384060v1
Probing Enzymatic PET Degradation: Molecular Dynamics Analysis of Cutinase Adsorption and Stability Mehdi Sahihi,Pierre Fayon,Lionel Nauton,Florent Goujon,Julien Devémyet al. Journal of Chemical Information and Modeling, 2024, 64 (10), pp.4112-4120. ⟨10.1021/acs.jcim.4c00079⟩ Article dans une revue hal-04600374v1
Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]Isoquinolines Mathilde Defois,Chloé Rémondin,Béatrice Josselin,Lionel Nauton,Vincent Théryet al. Molecules, 2022, 27 (17), pp.5578. ⟨10.3390/molecules27175578⟩ Article dans une revue hal-03765284v1
Cleavage of Aliphatic α-Hydroxy Ketones by Evolved Transketolase from Geobacillus stearothermophilus Hubert Casajus,Aurélie Lagarde,Lionel Nauton,Nazim Ocal,Martin Leremboureet al. ACS Catalysis, 2022, 12, pp.3566-3576. ⟨10.1021/acscatal.1c05140⟩ Article dans une revue hal-03607757v1
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors Laurent Gavara,Federica Verdirosa,Laurent Sevaille,Alice Legru,Giuseppina Corsicaet al. Bioorganic and Medicinal Chemistry, 2022, 72, pp.116964. ⟨10.1016/j.bmc.2022.116964⟩ Article dans une revue hal-03767295v1
4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-b-lactamase inhibitors Laurent Gavara,Alice Legru,Federica Verdirosa,Laurent Sevaille,Lionel Nautonet al. Bioorganic Chemistry, 2021, 113, pp.105024. ⟨10.1016/j.bioorg.2021.105024⟩ Article dans une revue hal-03358457v1
QM/MM Study of Human Transketolase: Thiamine Diphosphate Activation Mechanism and Complete Catalytic Cycle Lionel Nauton,Laurence Hecquet,Vincent Théry Journal of Chemical Information and Modeling, 2021, ⟨10.1021/acs.jcim.1c00190⟩ Article dans une revue hal-03286397v1
Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest Nahida Mokhtari Brikci-Nigassa,Lionel Nauton,Pascale Moreau,Olivier Mongin,Raphael E Duvalet al. Bioorganic Chemistry, 2020, 94, pp.103347. ⟨10.1016/j.bioorg.2019.103347⟩ Article dans une revue hal-02404054v1
4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition Laurent Gavara,Federica Verdirosa,Alice Legru,Paola Sandra Mercuri,Lionel Nautonet al. Biomolecules, 2020, 10 (8), pp.1094. ⟨10.3390/biom10081094⟩ Article dans une revue hal-02997710v1
Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia Alexia Visseq,Amélie Descheemaeker,Nicolas Pinto-Pardo,Lionel Nauton,Vincent Theryet al. European Journal of Medicinal Chemistry, 2020, 187, pp.111917. ⟨10.1016/j.ejmech.2019.111917⟩ Article dans une revue hal-02444268v1
Enzymatic Synthesis of Aliphatic Acyloins through Thermostable Transketolase Catalyzed-Reaction Hubert Casajus,Aurélie Lagarde,Martin Leremboure,Thomas De Dios Miguel,Lionel Nautonet al. ChemCatChem, 2020, ⟨10.1002/cctc.202001160⟩ Article dans une revue hal-02995504v1
Pyruvate Aldolases Catalyze Cross-Aldol Reactions between Ketones: Highly Selective Access to Multi-Functionalized Tertiary Alcohols Victor Laurent,Léa Gourbeyre,Alexandre Uzel,Virgil Hélaine,Lionel Nautonet al. ACS Catalysis, 2020, 10 (4), pp.2538-2543. ⟨10.1021/acscatal.9b05512⟩ Article dans une revue hal-02907546v1
NC α‐ gem ‐dimethylated peptoid side chains: A novel approach for structural control and peptide sequence mimetics Radhe Shyam,Lionel Nauton,Gaetano Angelici,Olivier Roy,Claude Taillefumieret al. Biopolymers, 2019, 110, pp.e23273. ⟨10.1002/bip.23273⟩ Article dans une revue hal-02194898v1
Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies Waël Zeinyeh,Yannick Esvan,Béatrice Josselin,Blandine Baratte,Stéphane Bachet al. Bioorganic and Medicinal Chemistry, 2019, 27 (10), pp.2083-2089. ⟨10.1016/j.bmc.2019.04.005⟩ Article dans une revue hal-02164744v1
Evolved Thermostable Transketolase for Stereoselective Two-Carbon Elongation of Non-Phosphorylated Aldoses to Naturally Rare Ketoses Marion Lorillière,Romain Dumoulin,Mélanie L’enfant,Agnès Rambourdin,Vincent Theryet al. ACS Catalysis, 2019, 9 (6), pp.4754-4763. ⟨10.1021/acscatal.9b01339⟩ Article dans une revue hal-02195534v1
Achiral Hydroxypyruvaldehyde Phosphate as a Platform for Multi-Aldolases Cascade Synthesis of Diuloses and for a Quadruple Acetaldehyde Addition Catalyzed by 2-Deoxyribose-5-Phosphate Aldolases Victor Laurent,Virgil Hélaine,Carine Vergne-Vaxelaire,Lionel Nauton,Mounir Traïkiaet al. ACS Catalysis, 2019, 9 (10), pp.9508-9512. ⟨10.1021/acscatal.9b02668⟩ Article dans une revue hal-02329545v1
Diastereoselective Synthesis of 2,6-Disubstituted-1,2,3,6-Tetrahydropyridines through a Palladium-Catalyzed Intramolecular Allylic Amination Alexia Visseq,Thibaut Boibessot,Lionel Nauton,Vincent Thery,Fabrice Anizonet al. European Journal of Organic Chemistry, 2019, 2019 (47), pp.7686-7702. ⟨10.1002/ejoc.201901520⟩ Article dans une revue hal-02444228v1
Topologically Diverse Shapes Accessible by Modular Design of Arylopeptoid Macrocycles Thomas Hjelmgaard,Lionel Nauton,Francesco de Riccardis,Laurent Jouffret,Sophie Faure Organic Letters, 2018, 20 (1), pp.268 - 271. ⟨10.1021/acs.orglett.7b03660⟩ Article dans une revue hal-01705225v1
Synthesis of Branched-Chain Sugars with a DHAP-Dependent Aldolase: Ketones are Electrophile Substrates of Rhamnulose-1- phosphate Aldolases Victor Laurent,Ekaterina Darii,Angelina Aujon,Marine Debacker,Jean-Louis Petitet al. Angewandte Chemie International Edition, 2018, 57 (19), pp.5467 - 5471. ⟨10.1002/anie.201712851⟩ Article dans une revue hal-02323732v1
A catalytic intramolecular nitrene insertion into a copper(I)–N-heterocyclic carbene bond yielding fused nitrogen heterocycles. Kévin Fauché,Lionel Nauton,Laurent Jouffret,Federico Cisnetti,Arnaud Gautier Chemical Communications, 2017, 53, pp.2402-2405. ⟨10.1039/C6CC09160A⟩ Article dans une revue hal-01546151v1
1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases Laurent Sevaille,Laurent Gavara,Carine Bebrone,Filomena De luca,Lionel Nautonet al. ChemMedChem, 2017, 12 (12), pp.972-985. ⟨10.1002/cmdc.201700186⟩ Article dans une revue hal-02923462v1
Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c. Yannick J. Esvan,Francis Giraud,Elisabeth Pereira,Virginie Suchaud,Lionel Nautonet al. Bioorganic and Medicinal Chemistry, 2016, 24, pp.3116-3124. ⟨10.1016/j.bmc.2016.05.032⟩ Article dans une revue hal-01367761v1
Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co–crystal structure. Yannick J. Esvan,Wael Zeinyeh,Thibaut Boibessot,Lionel Nauton,Vincent Théryet al. European Journal of Medicinal Chemistry, 2016, 118, pp.170-177. ⟨10.1016/j.ejmech.2016.04.004⟩ Article dans une revue hal-01308803v1
Insights into the Thiamine Diphosphate Enzyme Activation Mechanism: Computational Model for Transketolase Using a Quantum Mechanical/Molecular Mechanical Method. Lionel Nauton,Virgil Hélaine,Vincent Théry,Laurence Hecquet Biochemistry, 2016, 55, pp.2144-2152. ⟨10.1021/acs.biochem.5b00787⟩ Article dans une revue hal-01323789v1
Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives. Wael Zeinyeh,Yannick J. Esvan,Lionel Nauton,Nadège Loaëc,Laurent Meijeret al. Bioorganic and Medicinal Chemistry Letters, 2016, 26, pp.4327-4329. ⟨10.1016/j.bmcl.2016.07.032⟩ Article dans une revue hal-01367659v1
Water-Soluble Gold–N-Heterocyclic Carbene Complexes for the Catalytic Homogeneous Acid- and Silver-Free Hydration of Hydrophilic Alkynes. Houssein Ibrahim,Pierre de Frémont,Pierre Braunstein,Vincent Théry,Lionel Nautonet al. Advanced Synthesis and Catalysis, 2015, 357, pp.3893-3900. ⟨10.1002/adsc.201500729⟩ Article dans une revue istex hal-01264762v1
Engineering a Thermostable Transketolase for Unnatural Conversion of (2S)-Hydroxyaldehyde. Juliane Abdoul-Zabar,Marion Lorillière,Dong Yi,Thangavelu Saravanan,Titu Devamaniet al. Advanced Synthesis and Catalysis, 2015, 357, pp.1715-1720. ⟨10.1002/adsc.201500207⟩ Article dans une revue istex hal-01206477v1
New N-1,N-10 bridged pyrrolo[2,3-a]carbazole-3-carbaldehyde: synthesis and biological activities. Francis Giraud,Marion Bourhis,Lionel Nauton,Vincent Théry,Lars Herfindalet al. Bioorganic Chemistry, 2014, 57, pp.108-115. ⟨10.1016/j.bioorg.2014.09.004⟩ Article dans une revue istex hal-01077457v1
Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition Virginie Suchaud,Laurent Gavara,Francis Giraud,Lionel Nauton,Vincent Théryet al. Bioorganic and Medicinal Chemistry, 2014, 22, pp.4704-4710. ⟨10.1016/j.bmc.2014.07.011⟩ Article dans une revue istex hal-01077451v1
New potent and selective inhibitor of Pim-1/3 protein kinases sensitizes human colon carcinoma cells to doxorubicin. Pascale Moreau,Lyubov G. Dezhenkova,Fabrice Anizon,Lionel Nauton,Vincent Theryet al. Anti-Cancer Agents in Medicinal Chemistry, 2014, 14, pp.1228-1236. ⟨10.2174/1871520614666140825124456⟩ Article dans une revue istex hal-01077420v1
Macrocyclic arylopeptoids - a novel type of cyclic N-alkylated aromatic oligoamides forming nanotubular assemblies. Thomas Hjelmgaard,Olivier Roy,Lionel Nauton,Malika El-Ghozzi,Daniel Avignantet al. Chemical Communications, 2014, 50, pp.3564-3567. ⟨10.1039/C4CC00821A⟩ Article dans une revue hal-00987596v1
Synthesis, characterization, X-ray structure, DNA cleavage and cytotoxic activities of palladium(II) complexes of 4-phenyl-3-thiosemicarbazide and triphenylphosphine. Fillipe Vieira Rocha,Carolina Valério Barra,Antonio Eduardo Mauro,Iracilda Z. Carlos,Lionel Nautonet al. European Journal of Inorganic Chemistry, 2013, pp.4499-4505 Article dans une revue hal-00948885v1
Structure-Based Design of PDZ Ligands as Inhibitors of 5-HT2A Receptor/PSD-95 PDZ1 Domain Interaction Possessing Anti-hyperalgesic Activity Alexandre Vogrig,Liam Dorr,Naoual Bouzidi,Benjamin Boucherle,Anne-Sophie Wattiezet al. ACS Chemical Biology, 2013, 8, pp.2209-2216. ⟨10.1021/cb400308u⟩ Article dans une revue hal-00948867v1
Are Cu(I)-mesoionic NHC carbenes associated with nitrogen additives the best Cu-carbene catalysts for the azide-alkyne click reaction in solution? A case study. Stephan Hohloch,Biprajit Sarkar,Lionel Nauton,Federico Cisnetti,Arnaud Gautier Tetrahedron Letters, 2013, 54, pp.1808-1812 Article dans une revue hal-00812528v1
Luminogenic &quot;Clickable&quot; Lanthanide Complexes for Protein Labeling. Nicolas Candelon,Niculina D. Hădade,Mihaela Matache,Jean-Louis Canet,Federico Cisnettiet al. Chemical Communications, 2013, 49, pp.9206-9208 Article dans une revue hal-00950489v1
Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors. Laurent Gavara,Virginie Suchaud,Lionel Nauton,Vincent Théry,Fabrice Anizonet al. Bioorganic and Medicinal Chemistry Letters, 2013, 23 (8), pp.2298-2301. ⟨10.1016/j.bmcl.2013.02.074⟩ Article dans une revue istex hal-01089114v1
Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors. Virginie Suchaud,Laurent Gavara,Emmanuelle Saugues,Lionel Nauton,Vincent Théryet al. Bioorganic and Medicinal Chemistry, 2013, 21 (14), pp.4102-4111. ⟨10.1016/j.bmc.2013.05.011⟩ Article dans une revue istex hal-01089084v1
Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors. Francis Giraud,Rufine Akué-Gédu,Lionel Nauton,Nicolas Candelon,Eric Debitonet al. European Journal of Medicinal Chemistry, 2012, 56, pp.225-236 Article dans une revue hal-00786353v1
Clicked europium dipicolinate complexes for protein X-ray structure determination Romain Talon,Lionel Nauton,Jean-Louis Canet,Richard Kahn,Eric Girardet al. Chemical Communications, 2012, 48, pp.11886-11888 Article dans une revue hal-00787224v1
Access to functionalised silver(I) and gold(I) N-heterocyclic carbenes by [2+3] dipolar cycloadditions. Audrey Hospital,Clémentine Gibard,Christelle Gaulier,Lionel Nauton,Vincent Theryet al. Dalton Transactions, 2012, 41, pp.6803-6812 Article dans une revue hal-00711788v1
FSAB: A new fructose-6-phosphate aldolase from Escherichia coli. Cloning, over-expression and comparative kinetic characterization with FSAA Israel Sanchez-Moreno,Lionel Nauton,Vincent Théry,Agnès Pinet,Jean-Louis Petitet al. Journal of Molecular Catalysis B: Enzymatic, 2012, 84, pp.9-14 Article dans une revue hal-00786230v1
Synthesis, protein kinase inhibitory potencies and in vitro antiproliferative activities of meridianin derivatives. Francis Giraud,Georges Alves,Eric Debiton,Lionel Nauton,Vincent Theryet al. Journal of Medicinal Chemistry, 2011, 54, pp.4474-4489 Article dans une revue hal-00609607v1
A platinum Chugaev carbene complex as a potent anticancer agent Georges Alves,Laurent Morel,Malika El-Ghozzi,Daniel Avignant,Bertrand Legeretet al. Chemical Communications, 2011, 47, pp.7830-7832 Article dans une revue hal-00609652v1
Synthesis and molecular modelling study of new trimeric quinoline derivatives Emmanuelle Saugues,Lionel Nauton,Vincent Thery,Fabrice Anizon,Pascale Moreau Bioorganic Chemistry, 2011, 39, pp.143-150 Article dans une revue hal-00625030v1
Aromatic Nitrogen Donors for Efficient Copper(I)-NHC CuAAC under reductant-free conditions. Marie-Laure Teyssot,Lionel Nauton,Jean-Louis Canet,Federico Cisnetti,Aurélien Chevryet al. European Journal of Organic Chemistry, 2010, pp.3507-3515. ⟨10.1002/ejoc.201000046⟩ Article dans une revue istex hal-00492922v1
Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles Rufine Akué-Gédu,Lionel Nauton,Vincent Thery,Jenny Bain,Philip Cohenet al. Bioorganic and Medicinal Chemistry, 2010, 18, pp.6865-6873 Article dans une revue hal-00530591v1
Click Chelators – The Behavior of Platinum and Palladium Complexes in the Presence of Guanosine and DNA Aurélien Chevry,Marie-Laure Teyssot,Aurélie Maisonial,Pascale Lemoine,Bernard Viossatet al. European Journal of Inorganic Chemistry, 2010, 22, pp.3513-3519. ⟨10.1002/ejic.201000183⟩ Article dans une revue istex hal-00530546v1
Structural insights into the design of inhbitors for the L1 metallo-ß-lactamase from Stenotrophomonas maltophilia Lionel Nauton,Richard Kahn,G. Garau,Jean-François Hernandez,Otto Dideberg Journal of Molecular Biology, 2008, 1, pp.257-269. ⟨10.1016/j.jmb.2007.10.036⟩ Article dans une revue istex hal-00341669v1
X-ray spectroscopy and X-ray diffraction at wavelengths near the K-absorption edge of phosphorus. Valérie Biou,Peter Bösecke,Jean Marie Bois,Gérard Brandolin,Richard Kahnet al. Journal of Synchrotron Radiation, 2005, 12 (Pt 4), pp.402-9. ⟨10.1107/S0909049505009222⟩ Article dans une revue hal-00376039v1

Brevet (1)

Nouveaux peptoides et leur utilisation dans la prevention ou le traitement de la douleur chronique Jérôme Busserolles,Emmanuel Bourinet,Claude Taillefumier,Olivier Roy,Lionel Nautonet al. France, N° de brevet: WO2022074313A1. 2022 Brevet hal-04975361v1

Communication dans un congrès (3)

Synthesis, protein kinase inhibitory potencies and in vitro antiproliferative activities of meridianin derivatives Pascale Moreau,Francis Giraud,Elisabeth Pereira,Fabrice Anizon,Georges Alveset al. 17th European Symposium on Organic Chemistry, Jul 2011, Hersonissos, Greece Communication dans un congrès hal-00609975v1
Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles Fabrice Anizon,Rufine Akué-Gédu,Lionel Nauton,Vincent Thery,J. Bainet al. 17th European Symposium on Organic Chemistry, Hersonissos (Grèce), 10-15 juillet 2011, Jul 2011, Hersonissos, Greece Communication dans un congrès hal-00609939v1
Edifices glycoconjugués multivalents. Antigènes Tn – béta-Peptides Marielle Barra,Olivier Roy,Lionel Nauton,Claude Taillefumier SyCOCAL VI, Symposium de Chimie Organique en Centre-Auvergne-Limousin, Sep 2008, La Bourboule, France Communication dans un congrès hal-00323171v1