Lionel Ulmann Professeur de Biochimie - IUT de Laval

Présentation

Actuellement directeur adjoint du laboratoire BiOSSE - Biologie des Organismes, Stress, Santé, Environnement - à Le Mans Université, je co-anime l'axe de recherche MIMMA-Métabolisme et Ingénierie des Molécules des Microalgues et Applications.

J'ai obtenu un doctorat en Physiologie et Biochimie de la Nutrition à l'Université de Bourgogne en 1991.En 2018, j'ai présenté mon Habilitation à Diriger des Recherches en Biochimie et Biologie Moléculaire à Le Mans Université.

Mes activités de recherche se développent dans deux domaines :

la régulation du métabolisme des lipides et des acides gras polyinsaturés des microalgues marines;

l'utilisation des molécules bioactives des microalgues dans la santé et la prévention des maladies.

Le premier domaine de recherche est centré sur la réponse des diatomées marines soumises à un stress nutritif, afin de déterminer quels mécanismes cellulaires sont impliqués dans le transport, le stockage et l'utilisation des lipides. Le deuxième domaine de recherche est davantage une approche appliquée grâce à des collaborations avec des partenaires industriels pour la valorisation des molécules produites par les microalgues et leurs bénéfices pour la santé.

Publications

Article dans une revue (48)

Spirulina liquid extract regulates gene expression related to glucose and lipid metabolisms of soleus muscle during exercise training in young male Wistar rats fed a high-fat diet Jordi Vignaud,Céline Loiseau,Martine Côme,Josiane Hérault,Claire Mayeret al. Nutrition Research, 2025, ⟨10.1016/j.nutres.2025.09.006⟩ Article dans une revue hal-05266390v1
Chrysolaminarin metabolism in diatoms: Pathways, regulation, and biotechnological perspectives Anthony Kwasiborski,Abhishek Saxena,Thomas Kiran Marella,Céline Loiseau,Archana Tiwariet al. Journal of Applied Phycology, 2025, ⟨10.1007/s10811-025-03695-7⟩ Article dans une revue hal-05317427v1
Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation Victor Murison,Josiane Hérault,Justine Marchand,Lionel Ulmann Biological Reviews, 2025, ⟨10.1111/brv.70006⟩ Article dans une revue hal-04987301v1
Combined Effects of Spirulina Liquid Extract and Endurance Training on Aerobic Performance and Muscle Metabolism Adaptation in Wistar Rats Jordi Vignaud,Céline Loiseau,Martine Côme,Isabelle Martin,Rova Rasoanarivoet al. Nutrients, 2025, 17 (2), pp.283. ⟨10.3390/nu17020283⟩ Article dans une revue hal-04887681v1
Response of varying combined nutrients on biomass and biochemical composition of marine diatoms Chaetoceros gracilis and Thalassiosira weissflogii Raya Bhattacharjya,Rashi Tyagi,Subha Rastogi,Lionel Ulmann,Archana Tiwari Bioresource Technology, 2024, 394, pp.130274. ⟨10.1016/j.biortech.2023.130274⟩ Article dans une revue hal-05295700v1
Neutral lipid and chrysolaminarin metabolic pathways during nitrogen starvation and recovery in the diatom Phaeodactylum tricornutum Victor Murison,Josiane Hérault,Sabrina Guinio,Martine Côme,Céline Loiseauet al. Algal Research - Biomass, Biofuels and Bioproducts, 2024, 82, pp.103621. ⟨10.1016/j.algal.2024.103621⟩ Article dans une revue hal-04675343v1
Bioinformatics-Based Screening Approach for the Identification and Characterization of Lipolytic Enzymes from the Marine Diatom Phaeodactylum tricornutum Victor Murison,Josiane Hérault,Benoît Schoefs,Justine Marchand,Lionel Ulmann Marine drugs, 2023, 21 (2), pp.125. ⟨10.3390/md21020125⟩ Article dans une revue hal-04092790v1
Comparison of two Phaeodactylum tricornutum ecotypes under nitrogen starvation and resupply reveals distinct lipid accumulation strategies but a common degradation process Victor Murison,Josiane Hérault,Martine Côme,Sabrina Guinio,Alexis Lebonet al. Frontiers in Plant Science, 2023, 14, ⟨10.3389/fpls.2023.1257500⟩ Article dans une revue (data paper) hal-04215015v1
Microalgae Produce Antioxidant Molecules with Potential Preventive Effects on Mitochondrial Functions and Skeletal Muscular Oxidative Stress Jordi Vignaud,Céline Loiseau,Josiane Hérault,Claire Mayer,Martine Cômeet al. Antioxidants , 2023, 12 (5), pp.1050. ⟨10.3390/antiox12051050⟩ Article dans une revue hal-04092798v1
Lysophosphatidylcholine-DHA Specifically Induces Cytotoxic Effects of the MDA-MB-231 Human Breast Cancer Cell Line In Vitro—Comparative Effects with Other Lipids Containing DHA Dalal Mohamad Ali,Kevin Hogeveen,Rose-Marie Orhant,Tiphaine Le Gal de Kerangal,Françoise Erganet al. Nutrients, 2023, 15 (9), pp.2137. ⟨10.3390/nu15092137⟩ Article dans une revue hal-04092785v1
Contribution of n-3 Long-Chain Polyunsaturated Fatty Acids to the Prevention of Breast Cancer Risk Factors Mostefa Fodil,Vincent Blanckaert,Lionel Ulmann,Virginie Mimouni,Benoît Chénais International Journal of Environmental Research and Public Health, 2022, 19 (13), pp.7936. ⟨10.3390/ijerph19137936⟩ Article dans une revue hal-03710879v1
The Potential of the Marine Microalga Diacronema lutheri in the Prevention of Obesity and Metabolic Syndrome in High-Fat-Fed Wistar Rats Claire Mayer,Martine Côme,Lionel Ulmann,Isabelle Martin,Graziella Chini Zittelliet al. Molecules, 2022, 27 (13), pp.4246. ⟨10.3390/molecules27134246⟩ Article dans une revue hal-03710874v1
The Marine Microalga, Tisochrysis lutea, Protects against Metabolic Disorders Associated with Metabolic Syndrome and Obesity Claire Mayer,Léo Richard,Martine Côme,Lionel Ulmann,Hassan Nazihet al. Nutrients, 2021, 13 (2), pp.1-17. ⟨10.3390/nu13020430⟩ Article dans une revue hal-03124337v1
Protective Action of Ostreococcus tauri and Phaeodactylum tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells Manon Le Goff,Antoine Delbrut,Marie Quinton,Rémi Pradelles,Maelle Bescheret al. Marine drugs, 2019, 18 (1), pp.3. ⟨10.3390/md18010003⟩ Article dans une revue hal-02441226v1
Microalgal carotenoids and phytosterols regulate biochemical mechanisms involved in human health and disease prevention Manon Le Goff,E. Le Ferrec,Claire Mayer,Virginie Mimouni,Dominique Lagadic-Gossmannet al. Biochimie, 2019, 167, pp.106-118. ⟨10.1016/j.biochi.2019.09.012⟩ Article dans une revue hal-02302332v1
Nitrogen and phosphorus limitations induce carbon partitioning and membrane lipid remodelling in the marine diatom Phaeodactylum tricornutum Bing Huang,Justine Marchand,Vincent Blanckaert,Ewa Lukomska,Lionel Ulmannet al. European Journal of Phycology, 2019, 54 (3), pp.342-358. ⟨10.1080/09670262.2019.1567823⟩ Article dans une revue hal-02302335v1
A comparative study on the effect of argan oil versus fish oil on risk factors for cardio-vascular disease in high-fat-fed rats Adil Haimeur,Nadia Meskini,Virginie Mimouni,Lionel Ulmann,Hafida Messaouriet al. Nutrition, 2019, 57, pp.32-39. ⟨10.1016/j.nut.2018.05.027⟩ Article dans une revue istex hal-02302338v1
PAHs increase the production of extracellular vesicles both in vitro in endothelial cells and in vivo in urines from rats Manon Le Goff,Dominique Lagadic-Gossmann,Remi Latour,Normand Podechard,Nathalie Grovaet al. Environmental Pollution, 2019, 255, pp.113171. ⟨10.1016/j.envpol.2019.113171⟩ Article dans une revue hal-02302334v1
Preventive Effects of the Marine Microalga Phaeodactylum tricornutum, Used as a Food Supplement, on Risk Factors Associated with Metabolic Syndrome in Wistar Rats Claire Mayer,Martine Côme,Lionel Ulmann,Graziella Chini Zittelli,Cecilia Faraloniet al. Nutrients, 2019, 11 (5), pp.1069. ⟨10.3390/nu11051069⟩ Article dans une revue hal-02495591v1
Proximate Analysis, Lipid Profile, Microbiological and Pigment Characterization of Chlorella Dry Powder Produced in a 20 L Agitated Photobioreactor Luis Torres,Luis Corzo,Virginie Mimouni,Lionel Ulmann Asian Journal of Biotechnology and Bioresource Technology, 2017, 2 (2), pp.1-10. ⟨10.9734/AJB2T/2017/38220⟩ Article dans une revue hal-02303544v1
Microalgal Fatty Acids and Their Implication in Health and Disease Lionel Ulmann,Vincent Blanckaert,Virginie Mimouni,Mats Andersson,Benoît Schoefset al. Mini-Reviews in Medicinal Chemistry, 2017, 17 (12), ⟨10.2174/1389557516666160722132736⟩ Article dans une revue istex hal-01901146v1
Modulation of lipid biosynthesis by stress in diatoms Olga Sayanova,Virginie Mimouni,Lionel Ulmann,Annick Morant-Manceau,Virginie Pasquetet al. Philosophical Transactions of the Royal Society B: Biological Sciences, 2017, 372 (1728), pp.20160407. ⟨10.1098/rstb.2016.0407⟩ Article dans une revue hal-02001096v1
Fish Oil and Microalga Omega-3 as Dietary Supplements: A Comparative Study on Cardiovascular Risk Factors in High-Fat Fed Rats Adil Haimeur,Virginie Mimouni,Lionel Ulmann,Anne-Sophie Martineau,Hafida Messaouriet al. Lipids, 2016, 51, pp.1037-1049. ⟨10.1007/s11745-016-4177-2⟩ Article dans une revue hal-02001042v1
Light Intensity Regulates LC-PUFA Incorporation into Lipids of Pavlova lutheri and the Final Desaturase and Elongase Activities Involved in Their Biosynthesis Freddy Guihéneuf,Virginie Mimouni,Gérard Tremblin,Lionel Ulmann Journal of Agricultural and Food Chemistry, 2015, 63 (4), pp.1261-1267. ⟨10.1021/jf504863u⟩ Article dans une revue hal-02047476v1
Marine microalgae used as food supplements and their implication in preventing cardiovascular diseases Virginie Mimouni,Lionel Ulmann,Adil Haimeur,Frédérique Guéno,Nadia Meskiniet al. OCL Oilseeds and fats crops and lipids, 2015, 22 (4), pp.D409. ⟨10.1051/ocl/2015015⟩ Article dans une revue hal-02001045v1
Fatty acids profile and temperature in the cultured marine diatom Odontella aurita Virginie Pasquet,Lionel Ulmann,Virginie Mimouni,Freddy Guihéneuf,Boris Jacquetteet al. Journal of Applied Phycology, 2014, 26 (6), pp.2265-2271. ⟨10.1007/s10811-014-0252-3⟩ Article dans une revue hal-02001057v1
Maternal supplementation with n-3 long chain polyunsaturated fatty acids during perinatal period alleviates the metabolic syndrome disturbances in adult hamster pups fed a high-fat diet after weaning Fatima Kasbi-Chadli,Clair-Yves Boquien,Gilles Simard,Lionel Ulmann,Virginie Mimouniet al. Journal of Nutritional Biochemistry, 2014, 25 (7), pp.726-733. ⟨10.1016/j.jnutbio.2014.03.003⟩ Article dans une revue istex hal-02636983v1
Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri Freddy Guihéneuf,Lionel Ulmann,Virginie Mimouni,Gérard Tremblin Phytochemistry, 2013, 90, pp.43-49. ⟨10.1016/j.phytochem.2013.02.014⟩ Article dans une revue istex hal-02001060v1
Argan oil prevents prothrombotic complications by lowering lipid levels and platelet aggregation, enhancing oxidative status in dyslipidemic patients from the area of Rabat (Morocco) Adil Haimeur,Hafida Messaouri,Lionel Ulmann,Virginie Mimouni,Azelarab Masraret al. Lipids in Health and Disease, 2013, 12 (1), pp.107. ⟨10.1186/1476-511X-12-107⟩ Article dans une revue hal-02303556v1
Plastids of Marine Phytoplankton Produce Bioactive Pigments and Lipids Parisa Heydarizadeh,Isabelle Poirier,Damien Loizeau,Lionel Ulmann,Virginie Mimouniet al. Marine drugs, 2013, 11 (9), pp.3425-3471. ⟨10.3390/md11093425⟩ Article dans une revue hal-02304112v1
The Potential of Microalgae for the Production of Bioactive Molecules of Pharmaceutical Interest Virginie Mimouni,Lionel Ulmann,Virginie Pasquet,Marie Mathieu,Laurent Picotet al. Current Pharmaceutical Biotechnology, 2012, 13 (15), pp.2733-2750. ⟨10.2174/138920112804724828⟩ Article dans une revue hal-01248050v1
The role of Odontella aurita, a marine diatom rich in EPA, as a dietary supplement in dyslipidemia, platelet function and oxidative stress in high-fat fed rats Adil Haimeur,Lionel Ulmann,Virginie Mimouni,Frédérique Guéno,Fabienne Pineau-Vincentet al. Lipids in Health and Disease, 2012, 11, pp.147. ⟨10.1186/1476-511X-11-147⟩ Article dans une revue hal-02303557v1
Light-dependent utilization of two radiolabelled carbon sources, sodium bicarbonate and sodium acetate, and relationships with long chain polyunsaturated fatty acid synthesis in the microalga Pavlova lutheri (Haptophyta) Freddy Guihéneuf,Lionel Ulmann,Gerard Tremblin,Virginie Mimouni European Journal of Phycology, 2011, 46 (2), pp.143-152. ⟨10.1080/09670262.2011.577912⟩ Article dans une revue hal-02001099v1
No altered blood pressure and serum markers of oxidative stress after a long time dietary fish oil in the genetically 9 month-old type-2 diabetes Zucker rat Sompadthana Tricot,Virginie Mimouni,Sonia Rompion,Christelle Froger,Pierre Lacroixet al. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2010, 83 (4-6), pp.211-218. ⟨10.1016/j.plefa.2010.08.005⟩ Article dans une revue istex hal-02001103v1
Effect of UV stress on the fatty acid and lipid class composition in two marine microalgae Pavlova lutheri (Pavlovophyceae) and Odontella aurita (Bacillariophyceae) Freddy Guihéneuf,Manuela Fouqueray,Virginie Mimouni,Lionel Ulmann,Boris Jacquetteet al. Journal of Applied Phycology, 2010, 22 (5), pp.629-638. ⟨10.1007/s10811-010-9503-0⟩ Article dans une revue istex hal-02001107v1
Docosahexaenoic acid intake decreases proliferation, increases apoptosis and decreases the invasive potential of the human breast carcinoma cell line MDA-MB-231 Vincent Blanckaert,Lionel Ulmann,Virginie Mimouni,Antol Johann,Lucile Brancquartet al. International Journal of Oncology, 2010, 36 (3), ⟨10.3892/ijo_00000549⟩ Article dans une revue hal-02001122v1
Combined effects of irradiance level and carbon source on fatty acid and lipid class composition in the microalga Pavlova lutheri commonly used in mariculture Freddy Guihéneuf,Virginie Mimouni,Lionel Ulmann,Gérard Tremblin Journal of Experimental Marine Biology and Ecology, 2009, 369 (2), pp.136-143. ⟨10.1016/j.jembe.2008.11.009⟩ Article dans une revue istex hal-02001124v1
ENVIRONMENTAL FACTORS AFFECTING GROWTH AND OMEGA 3 FATTY ACID COMPOSITION IN SKELETONEMA COSTATUM. THE INFLUENCES OF IRRADIANCE AND CARBON SOURCE Freddy Guihéneuf,Virginie Mimouni,Lionel Ulmann,Gerard Tremblin Diatom Research, 2008, 23 (1), pp.93-103. ⟨10.1080/0269249X.2008.9705739⟩ Article dans une revue hal-02303567v1
Brain and hippocampus fatty acid composition in phospholipid classes of aged-relative cognitive deficit rats Lionel Ulmann,Virginie Mimouni,S. Roux,R. Porsolt,J.-P. Poisson Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2001, 64 (3), pp.189-195. ⟨10.1054/plef.2001.0260⟩ Article dans une revue istex hal-02001128v1
Age-related changes in antioxidant defence mechanisms and peroxidation in isolated hepatocytes from spontaneously hypertensive and normotensive rats Evelyne Véricel,Michel Narce,Lionel Ulmann,Jean-Pierre Poisson,Michel Lagarde Molecular and Cellular Biochemistry, 1994, 132 (1), pp.25-29. ⟨10.1007/bf00925671⟩ Article dans une revue istex hal-02303570v1
Incorporation of Δ6- and Δ5-desaturation fatty acids in liver microsomal lipid classes of obese Zucker rats fed n − 6 or n − 3 fatty acids Lionel Ulmann,Jean Paul Blond,Jean Pierre Poisson,Jean Bézard Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1994, 1214 (1), pp.73-78. ⟨10.1016/0005-2760(94)90011-6⟩ Article dans une revue istex hal-02303578v1
Age-related changes in Δ6 and Δ5 desaturase activities in rat liver microsomes C. Maniongul,J. Blond,Lionel Ulmann,Geoffroy Durand,J. Poissonet al. Lipids, 1993, 28 (4), pp.291-297. ⟨10.1007/BF02536313⟩ Article dans une revue istex hal-02303581v1
Relationship between rat liver microsomal Δ6 and Δ5 desaturase activities and fatty acid composition: comparative effects of coconut and salmon oils during protein restriction Lionel Ulmann,Mahmoud Bouziane,Virginie Mimouni,Jacques Belleville,Jean Pierre Poisson The Journal of Nutritional Biochemistry, 1992, 3 (4), pp.188-193. ⟨10.1016/0955-2863(92)90115-Y⟩ Article dans une revue istex hal-02303584v1
Elongation and desaturation of arachidonic and eicosapentaenoic acids in rat liver. Effect of clofibrate feeding Virginie Mimouni,Erling Christiansen,Jean Paul Blond,Lionel Ulmann,Jean-Pierre Poissonet al. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991, 1086 (3), pp.349-353. ⟨10.1016/0005-2760(91)90180-P⟩ Article dans une revue istex hal-02303586v1
Effects of age and dietary fatty acids on desaturase activities and on fatty acid composition on liver microsomal phospholipids of adult rats L. Ulmann,J.P. Blond,C. Maniongui,J.P. Poisson,G. Durandet al. Lipids, 1991, 26 (1), pp.127-133 Article dans une revue hal-02712734v1
Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of Δ6 and Δ9 desaturation, γ-linolenic and oleic acids: effect of age and of blackcurrant seed oil Lionel Ulmann,Jean-Pierre Poisson,Jean Paul Blond,Jean Bézard Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991, 1086 (2), pp.230-236. ⟨10.1016/0005-2760(91)90012-7⟩ Article dans une revue istex hal-02303589v1
Effects of age and dietary essential fatty acids on desaturase activities and on fatty acid composition of liver microsomal phospholipids of adult rats Lionel Ulmann,J. Blond,C. Maniongui,J. Poisson,Geoffroy Durandet al. Lipids, 1991, 26 (2), pp.127-133. ⟨10.1007/BF02544006⟩ Article dans une revue istex hal-02303592v1
The effect of dietary α-bromopalmitate on blood lipids in the rat Tor-Arne Hagve,Michel Narce,Morten Grønn,Erik Christensen,Lionel Ulmannet al. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1989, 1004 (1), pp.143-146. ⟨10.1016/0005-2760(89)90225-7⟩ Article dans une revue istex hal-02303594v1

Chapitre d'ouvrage (4)

Diatoms and Their Role in the Sustainable Agricultural Circular Economy Rinku Kaushik,Archana Tiwari,Lionel Ulmann Diatoms and Sustainable Agriculture, 1, CRC Press, pp.1-19, 2025, ⟨10.1201/9781003528036-1⟩ Chapitre d'ouvrage hal-05226185v1
Chapter 7 - Modulation of lipid biosynthesis by stress in diatoms Bing Huang,Virginie Mimouni,Annick Morant-Manceau,Justine Marchand,Lionel Ulmannet al. Handbook of algal technologies and phytochemicals, 2019, ISBN: 978-0-367-17819-2 Chapitre d'ouvrage hal-04916403v1
Lipids From Microalgae Virginie Mimouni,Aurélie Couzinet-Mossion,Lionel Ulmann,Gaëtane Wielgosz-Collin Microalgae in Health and Disease Prevention, Elsevier, pp.109-131, 2018, ⟨10.1016/B978-0-12-811405-6.00005-0⟩ Chapitre d'ouvrage hal-02303530v1
The polyunsaturated fatty acids from microalgae as potential sources for health and disease Lionel Ulmann,Virginie Mimouni,Vincent Blanckaert,Virginie Pasquet,Benoît Schoefset al. Angel Català. Polyunsaturated Fatty Acids: Sources, Antioxidant Properties and Health Benefits, Nova Science Publishers, 2013, 978-1-62948-151-7 Chapitre d'ouvrage hal-01906200v1

Communication dans un congrès (3)

Effects of age and dietary 18-3 omega-6 and 18-4 omega-3 on the delta 6-desaturations in rat liver microsomes J.P. Blond,Philippe Guesnet,L. Ulmann,C. Maniongui,J. Bezardet al. 2. International Conference on the Health Effects of omega-3 Polyunsaturated Fatty Acids, Mar 1990, Washington DC, United States Communication dans un congrès hal-02775576v1
Effet de l'age sur la capacite du foie a desaturer les acides gras chez le rat C. Maniongui,J.P. Blond,L. Ulmann,G. Durand,J. Bezard 5. Symposium sur Nutrition, Lipides, Lipoproteines, Mar 1991, Creteil, France Communication dans un congrès hal-02777764v1
Acides gras polyinsatures alimentaires et desaturations microsomales chez le rat. J.P. Blond,G. Durand,L. Ulmann,M.P. Lonjaret,J.P. Poissonet al. Congres International. 1. Congres Eurolipid, Jun 1989, Angers, France Communication dans un congrès hal-02783543v1