Cédric Logé

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Publications

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Synthesis and Biological Evaluation of Itraconazole Derivatives: Design in an Old Scaffold

Shuai Zhong , Apollonia Kalamatianou , Gonzalo Scalese , Cillian O’beirne , Marta Redrado et al.

Inorganic Chemistry, 2025, 64 (31), pp.16192-16203. ⟨10.1021/acs.inorgchem.5c02730⟩

Article dans une revue hal-05211856v1

Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2- a ]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy

Lhana Tisseur , Cédric Logé , Sandrine Cojean , Khadidiatou Gassama , Lilian Karcher et al.

RSC Medicinal Chemistry, 2025, 16, pp.3746-3763. ⟨10.1039/d5md00257e⟩

Article dans une revue hal-05173262v1

Investigating the C2 Modulation of the Imidazo[1,2‐ a ]pyrazine‐Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition

Lhana Tisseur , Sandrine Cojean , Khadidiatou Gassama , Cédric Logé , Fabrice Pagniez et al.

ChemMedChem, 2025, 20 (6), pp.e202400862. ⟨10.1002/cmdc.202400862⟩

Article dans une revue hal-05181232v1

Synthesis of New Dihydropyrimidine-2-Thione Derivatives and Their Antibacterial Screening

Ambeu-Loko N’ta Christelle Mélissa , Camara Mahama , Coulibaly Souleymane , Ouattara Logopho Hyacinthe , Stéphanie Kra et al.

Chemical Science International Journal, 2024, 33 (6), pp.145-154. ⟨10.9734/CSJI/2024/v33i6933⟩

Article dans une revue hal-05086170v1
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Potassium 6-Oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate

Camille Blouet , Stéphanie Letast , Thomas Robert , Stéphane Bach , Noël Pinaud et al.

Molbank, 2023, 2023 (4), pp.M1735. ⟨10.3390/M1735⟩

Article dans une revue hal-04805282v1
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Exosomes as New Biomarkers and Drug Delivery Tools for the Prevention and Treatment of Various Diseases: Current Perspectives

Qi Liu , Shiying Li , Amandine Dupuy , Hoa Le Mai , Nicolas Sailliet et al.

International Journal of Molecular Sciences, 2021, 22 (15), pp.7763. ⟨10.3390/ijms22157763⟩

Article dans une revue hal-03825290v2
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Tetraspanins: useful multifunction proteins for the possible design and development of small-molecule therapeutic tools

Jean-Michel Robert , Nathalie Gisèle Amoussou , Hubert Le Mai , Cédric Logé , Sophie Brouard

Drug Discovery Today, 2021, 26 (1), pp.56-68. ⟨10.1016/j.drudis.2020.10.022⟩

Article dans une revue hal-03795952v1
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Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases

Viet Hung Dao , Isabelle Ourliac-Garnier , Cédric Logé , Florence Mccarthy , Stéphane Bach et al.

Molecules, 2021, 26 (21), pp.6572. ⟨10.3390/molecules26216572⟩

Article dans une revue hal-03428747v1
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Untargeted Metabolomics Approach for the Discovery of Environment-Related Pyran-2-Ones Chemodiversity in a Marine-Sourced Penicillium restrictum

Van-Tuyen Le , Samuel Bertrand , Thibaut Robiou Du Pont , Fabrice Fleury , Nathalie Caroff et al.

Marine drugs, 2021, 19 (7), pp.378. ⟨10.3390/md19070378⟩

Article dans une revue hal-03825219v2
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New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation

Bruno Oyallon , Marie Brachet-Botineau , Cédric Logé , Thomas Robert , Stéphane Bach et al.

Molecules, 2021, 26 (4), pp.867. ⟨10.3390/molecules26040867⟩

Article dans une revue inserm-03272339v1
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New azole antifungals with a fused triazinone scaffold

David Montoir , Rémi Guillon , Sophie Gazzola , Isabelle Ourliac-Garnier , Kossi Efouako Soklou et al.

European Journal of Medicinal Chemistry, 2020, 189, pp.112082. ⟨10.1016/j.ejmech.2020.112082⟩

Article dans une revue hal-03412473v1
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4-cholesten-3-one decreases breast cancer cell viability and alters membrane raft-localized EGFR expression by reducing lipogenesis and enhancing LXR-dependent cholesterol transporters

Josiane Elia , Delphine Carbonnelle , Cédric Logé , Lucie Ory , Jean-Michel Huvelin et al.

Lipids in Health and Disease, 2019, 18 (1), pp.168. ⟨10.1186/s12944-019-1103-7⟩

Article dans une revue hal-04041192v2

Precise genome editing using a CRISPR-Cas9 method highlights the role of CoERG11 amino acid substitutions in azole resistance in Candida orthopsilosis

Florent Morio , Lisa Lombardi , Ulrike Binder , Cédric Logé , Estelle Robert et al.

Journal of Antimicrobial Chemotherapy, 2019, 74 (8), pp.2230-2238. ⟨10.1093/jac/dkz204⟩

Article dans une revue hal-03827474v1
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Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors

Bruno Oyallon , Marie Brachet-Botineau , Cédric Logé , Pascal Bonnet , Mohamed Souab et al.

European Journal of Medicinal Chemistry, 2018, 154, pp.101-109. ⟨10.1016/j.ejmech.2018.04.056⟩

Article dans une revue hal-03408667v1
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Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1

Vehary Sakanyan , Philippe Hulin , Rodolphe Alves de Sousa , Viviane Silva , Artur Hambardzumyan et al.

Scientific Reports, 2016, 6 (1), pp.21088. ⟨10.1038/srep21088⟩

Article dans une revue hal-03652537v1

Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors

Yvonnick Loidreau , Emmanuel Deau , Pascal Marchand , Marie-Renée Nourrisson , Cédric Logé et al.

European Journal of Medicinal Chemistry, 2015, 92, pp.124-134. ⟨10.1016/j.ejmech.2014.12.038⟩

Article dans une revue hal-01135195v1

Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1

Espérance Moine , Isabelle Dimier-Poisson , Cécile Enguehard-Gueiffier , Cédric Logé , Mélanie Pénichon et al.

European Journal of Medicinal Chemistry, 2015, 105, pp.80-105. ⟨10.1016/j.ejmech.2015.10.004⟩

Article dans une revue istex hal-02389861v1

Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells

Julien Defaux , Maud Antoine , Cédric Logé , Marc Le Borgne , Tilmann Schuster et al.

Bioorganic and Medicinal Chemistry Letters, 2014, 24 (16), pp.3748 - 3752. ⟨10.1016/j.bmcl.2014.06.078⟩

Article dans une revue hal-01683305v1
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Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells

Vehary Sakanyan , Marie Angelini , Mickael Le Béchec , Michèle Françoise Lecocq , Florence Benaiteau et al.

Scientific Reports, 2014, 4, pp.1-11. ⟨10.1038/srep03977⟩

Article dans une revue hal-01136283v1
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Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors

Amélie Bruel , Romain Beneteau , Mylène Chabanne , Olivier Lozach , Rémy Le Guevel et al.

Bioorganic and Medicinal Chemistry Letters, 2014, 24 (21), pp.5037 - 5040. ⟨10.1016/j.bmcl.2014.09.017⟩

Article dans une revue hal-01086026v1

Discovery of a Novel Broad-Spectrum Antifungal Agent Derived from Albaconazole

Rémi Guillon , Fabrice Pagniez , Carine Picot , Damien Hédou , Alain Tonnerre et al.

ACS Medicinal Chemistry Letters, 2013, 4 (2), pp.288-292. ⟨10.1021/ml300429p⟩

Article dans une revue hal-01015468v1

Novel synthesis of angular thiazolo[5,4-f] and [4,5-h]quinazolines, preparation of their linear thiazolo[4,5-g] and [5,4-g]quinazoline analogs

Damien Hédou , Rémi Guillon , Charlotte Lecointe , Cédric Logé , Elizabeth Chosson et al.

Tetrahedron, 2013, 69 (15), pp.3182-3191. ⟨10.1016/j.tet.2013.02.066⟩

Article dans une revue istex hal-01015586v1

Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5Hpyridazino[4,5-b]indoles as PI3Ka inhibitors.

A. Bruel , Cedric Logé , M.-L. de Tauzia , M. Ravache , Ronan Le Guével et al.

European Journal of Medicinal Chemistry, 2012, 57, pp.225-233

Article dans une revue hal-00764872v1

Study of N1-alkylation of indoles from the reaction of 2(or 3)-aminoindole-3-(or 2)carbonitriles with DMF-dialkylacetals

Yvonnick Loidreau , Sigismund Melissen , Vincent Levacher , Cédric Logé , Jérôme Graton et al.

Organic & Biomolecular Chemistry, 2012, 10 (25), pp.4916-4925. ⟨10.1039/c2ob25747e⟩

Article dans une revue hal-00997070v1

Design, Synthesis, and in vitro Antifungal Activity of 1-[(4-Substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

Rémi Guillon , Fabrice Pagniez , Francis Giraud , Damien Crépin , Carine Picot et al.

ChemMedChem, 2011, 6 (5), pp.816 - 825. ⟨10.1002/cmdc.201000530⟩

Article dans une revue istex hal-01689176v1
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Prostaglandins antagonistically control Bax activation during apoptosis

Lisenn Lalier , Pierre-François Cartron , Christophe Olivier , Cedric Logé , Gwenola Bougras et al.

Cell Death and Differentiation, 2010, ⟨10.1038/cdd.2010.128⟩

Article dans une revue hal-00587969v1

Synthesis and in vitro antifungal evaluation of 2-(2,4-difluorophenyl)-1-[(1 H -indol-3-ylmethyl)methylamino]-3-(1 H -1,2,4-triazol-1-yl)propan-2-ols

Rémi Guillon , Cédric Logé , Fabrice Pagniez , Véronique Ferchaud-Roucher , Muriel Duflos et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 2010, 26 (2), pp.261-269. ⟨10.3109/14756366.2010.503607⟩

Article dans une revue hal-04792103v1

Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature

Florent Morio , Cédric Logé , Bernard Besse , Christophe Hennequin , Patrice Le Pape

Diagnostic Microbiology and Infectious Disease, 2010, 66 (4), pp.373-384. ⟨10.1016/j.diagmicrobio.2009.11.006⟩

Article dans une revue istex hal-03830187v1

Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

Rémi Guillon , Francis Giraud , Cédric Logé , Marc Le Borgne , Carine Picot et al.

Bioorganic and Medicinal Chemistry Letters, 2009, 19 (20), pp.5833 - 5836. ⟨10.1016/j.bmcl.2009.08.089⟩

Article dans une revue istex hal-01689189v1

Synthesis and structure–activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

Francis Giraud , Rémi Guillon , Cédric Logé , Fabrice Pagniez , Carine Picot et al.

Bioorganic and Medicinal Chemistry Letters, 2009, 19 (2), pp.301 - 304. ⟨10.1016/j.bmcl.2008.11.101⟩

Article dans une revue istex hal-01689192v1

Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II

Francis Giraud , Cédric Logé , Fabrice Pagniez , Damien Crépin , Sophie Barres et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 2009, 24 (5), pp.1067 - 1075. ⟨10.1080/14756360802610795⟩

Article dans une revue hal-01689191v1

Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents

Ulrich Jacquemard , Nathalie Dias , Amélie Lansiaux , Christian Bailly , Cédric Logé et al.

Bioorganic and Medicinal Chemistry, 2008, 16 (9), pp.4932-4953. ⟨10.1016/j.bmc.2008.03.034⟩

Article dans une revue istex hal-04451556v1

Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

Francis Giraud , Cédric Logé , Fabrice Pagniez , Damien Crépin , Patrice Le Pape et al.

Bioorganic and Medicinal Chemistry Letters, 2008, 18 (6), pp.1820 - 1824. ⟨10.1016/j.bmcl.2008.02.027⟩

Article dans une revue istex hal-01689196v1

Docking Study of Ligands into the Colchicine Binding Site of Tubulin

Amaury Farce , Cedric Loge , Sebastien Gallet , Nicolas Lebegue , Pascal Carato et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 19 (6), pp.541-547. ⟨10.1080/14756360412331280545⟩

Article dans une revue hal-04451109v1

Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: Synthesis, biological evaluation and molecular modeling studies

Cédric Logé , Alexandra Testard , Valérie Thiéry , Olivier Lozach , Mélina Blairvacq et al.

European Journal of Medicinal Chemistry, 2008, 43 (7), pp.1469-1477. ⟨10.1016/j.ejmech.2007.09.020⟩

Article dans une revue istex hal-02357774v1

A 3D-QSAR CoMSIA study on 3-azolylmethylindoles as anti-leishmanial agents

Francis Giraud , Cédric Logé , Marc Le Borgne , Fabrice Pagniez , Young Min Na et al.

SAR and QSAR in Environmental Research, 2006, 17 (3), pp.299 - 309. ⟨10.1080/10659360600787494⟩

Article dans une revue hal-01689291v1

Thiazolo[5,4-f]quinazolin-9-ones, inhibitors of glycogen synthase kinase-3

Alexandra Testard , Cédric Logé , Benoît Léger , Jean-Michel Robert , Olivier Lozach et al.

Bioorganic and Medicinal Chemistry Letters, 2006, 16 (13), pp.3419-3423. ⟨10.1016/j.bmcl.2006.04.006⟩

Article dans une revue istex hal-02357746v1

Three-dimensional model of cytochrome P450 human aromatase

Cédric Logé , Marc Le Borgne , Pascal Marchand , Jean-Michel Robert , Guillaume Le Baut et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 2005, 20 (6), pp.581 - 585. ⟨10.1080/14756360500220574⟩

Article dans une revue hal-01689233v1

Modifying positions 2 or 8 of the imidazo[1,2-a]pyrazine lead compound CTN1122 affects its antileishmanial activity, L-CK1.2 kinase inhibition, and safety profile

Lhana Tisseur , Marc-Antoine Bazin , Sandrine Cojean , Fabrice Pagniez , Cédric Logé et al.

GP2A 2024, Aug 2024, Coimbra, Portugal

Communication dans un congrès hal-04708945v1

Développement de nouveaux inhibiteurs de TgCDPK1 à visée anti-toxoplasmique

Espérance Moine , Isabelle Dimier-Poisson , Cécile Enguehard-Gueiffier , Cedric Logé , Mélanie Pénichon et al.

6. Journées du Consortium antiParasitaire et antiFongique : CaPF-2016 " A la croisée des Mondes !", Consortium Anti-Parasitaire et Fongique (CaPF). FRA., Mar 2016, Tours, France. 49 p

Communication dans un congrès hal-02739722v1

Conception, synthèse et évaluation de nouveaux inhibiteurs de TgCDPK1 à visée anti-toxoplasmique

Espérance Moine , Isabelle Dimier-Poisson , Cécile Enguehard-Gueiffier , Mélanie Pouvreau , Nathalie Moiré et al.

28. Colloque Biotechnocentre, Biotechnocentre. FRA., Oct 2015, Seillac, France

Communication dans un congrès hal-02744066v1

Conception, synthèse et évaluation de nouveaux inhibiteurs de TgCDPK1 à visée anti-toxoplasmique

Espérance Moine , Isabelle Dimier-Poisson , Cécile Enguehard-Gueiffier , Cedric Logé , Mélanie Pénichon et al.

La journée recherche en Pharmacie, Université de Nantes (UN). FRA., Nov 2015, Nantes, France

Communication dans un congrès hal-02796250v1

Conception, synthèse et évaluation de nouveaux inhibiteurs de CDPK1 à visée anti-apicomplexes

Espérance Moine , Isabelle Dimier-Poisson , Cécile Enguehard-Gueiffier , Nathalie Moiré , M. Pouvreau et al.

7. édition du Club Toxo, Sep 2014, Tours, France

Communication dans un congrès hal-02800737v1

Conception, synthèse et évaluation de nouveaux inhibiteurs de TgCDPK1 à visée anti-toxoplasmique

Espérance Moine , Isabelle Dimier-Poisson , Cécile Enguehard-Gueiffier , Mélanie Pouvreau , Nathalie Moiré et al.

Days of the Research Federation in Infectious Diseases, Oct 2015, Orléans, France. 2015

Poster de conférence hal-02793392v1

Conception, synthesis and evaluation of new anti-<em>Toxoplasma gondii</em> agents designed to target CDPK1

Espérance Moine , Caroline Denevault-Sabourin , Françoise Debierre-Grockiego , Nathalie Moiré , Cedric Logé et al.

ITMO BMSV : “Frontiers of Chemical Biology: Investigating life with chemistry”, Jun 2014, Paris, France. , 2014

Poster de conférence hal-02793990v1

Synthesis, antifungal activity and molecular modeling studies of NL114, a new fluconazole analogue

N. Lebouvier , F. Pagniez , C. Logé , P. Pinson , J. Guillon et al.

16èmes Conférences Européennes du Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Sep 2007, Bordeaux, France. 2007

Poster de conférence hal-03379408v1

Application des micro-ondes pour la synthèse des 1-(1H-indol-1-yl) -2-phényl-3-(1H-1,2,4-triazol-1-yl) propan-2-ols

F. Giraud , M.-P. Lézé , N. Lebouvier , C. Logé , M. Le-Borgne et al.

13ème Journée Jeunes Chercheurs, Jan 2006, Paris, France. 2006

Poster de conférence hal-03379436v1