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Loic Hamon

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RNA and the RNA-binding protein FUS act in concert to prevent TDP-43 spatial segregation

Clément Demongin , Samuel Tranier , Vandana Joshi , Léa Ceschi , Bénédicte Desforges
Journal of Biological Chemistry, 2024, pp.105716. ⟨10.1016/j.jbc.2024.105716⟩
Journal articles hal-04455540v1
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FUS RRM regulates poly(ADP-ribose) levels after transcriptional arrest and PARP-1 activation on DNA damage

Evgeniya Mamontova , Marie-Jeanne Clément , Maria Sukhanova , Vandana Joshi , Ahmed Bouhss
Cell Reports, 2023, 42 (10), pp.113199. ⟨10.1016/j.celrep.2023.113199⟩
Journal articles hal-04231448v1
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FUS fibrillation occurs through a nucleation-based process below the critical concentration required for liquid–liquid phase separation

Emilie Bertrand , Clément Demongin , Ioana Dobra , Juan-Carlos Rengifo-Gonzalez , Anastasia S Singatulina
Scientific Reports, 2023, 13 (1), pp.7772. ⟨10.1038/s41598-023-34558-1⟩
Journal articles hal-04231423v1

YB-1 Structure/function relationship in the packaging of mRNPs and consequences for translation regulation and stress granule assembly in cells

Loic Hamon , Karina Budkina , David Pastre
Biochemistry (mosc.), 2022
Journal articles hal-04583907v1
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Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain

Anastasiia Samsonova , Krystel El Hage , Bénédicte Desforges , Vandana Joshi , Marie-Jeanne Clément
Communications Biology, 2021, 4 (1), pp.359. ⟨10.1038/s42003-021-01862-3⟩
Journal articles hal-03176308v1
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ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs

S. Pankivskyi , D. Pastré , E. Steiner , V. Joshi , A. Rynditch
Cellular and Molecular Life Sciences, 2021, 78, pp.1745-1763. ⟨10.1007/s00018-020-03610-y⟩
Journal articles hal-02968869v1
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YB-1 unwinds mRNA secondary structures in vitro and negatively regulates stress granule assembly in HeLa cells

Karina Budkina , Krystel El Hage , Marie-Jeanne Clément , Bénédicte Desforges , Ahmed Bouhss
Nucleic Acids Research, 2021, 49 (17), pp.10061-10081. ⟨10.1093/nar/gkab748⟩
Journal articles hal-03333572v1
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Inhibition of Transcription Induces Phosphorylation of YB-1 at Ser102 and Its Accumulation in the Nucleus

Dmitry Kretov , Daria Mordovkina , Irina Eliseeva , Dmitry Lyabin , Dmitry Polyakov
Cells, 2020, 9 (1), pp.104. ⟨10.3390/cells9010104⟩
Journal articles hal-02968925v1
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Regulation of Poly(ADP-Ribose) Polymerase 1 Activity by Y-Box-Binding Protein 1

Konstantin Naumenko , Mariya Sukhanova , Loic Hamon , Tatyana Kurgina , Elizaveta Alemasova
Biomolecules, 2020, 10 (9), pp.1325. ⟨10.3390/biom10091325⟩
Journal articles hal-02968966v1
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PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA

Anastasia Singatulina , Loic Hamon , Maria Sukhanova , Bénédicte Desforges , Vandana Joshi
Cell Reports, 2019, 27 (6), pp.1809-1821. ⟨10.1016/j.celrep.2019.04.031⟩
Journal articles hal-02167709v1

A Single-Molecule Atomic Force Microscopy Study of PARP1 and PARP2 Recognition of Base Excision Repair DNA Intermediates

Maria Sukhanova , Loic Hamon , Mikhail Kutuzov , Vandana Joshi , Sanae Abrakhi
Journal of Molecular Biology, 2019, 431 (15), pp.2655-2673. ⟨10.1016/j.jmb.2019.05.028⟩
Journal articles hal-02165889v1
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YB-1, an abundant core mRNA-binding protein, has the capacity to form an RNA nucleoprotein filament: a structural analysis

Dmitry Kretov , Marie-Jeanne Clément , Guillaume Lambert , Dominique Durand , Dmitry Lyabin
Nucleic Acids Research, 2019, 47 (6), pp.3127-3141. ⟨10.1093/nar/gky1303⟩
Journal articles hal-02114790v1

Relation Between Stress Granules and Cytoplasmic Protein Aggregates Linked to Neurodegenerative Diseases

Ioana Dobra , Serhii Pankivskyi , Anastasiia Samsonova , David Pastre , Loic Hamon
Current Neurology and Neuroscience Reports, 2018, 18 (12), pp.107. ⟨10.1007/s11910-018-0914-7⟩
Journal articles hal-02167725v1
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Microtubules as platforms for probing liquid–liquid phase separation in cells – application to RNA-binding proteins

Alexandre Maucuer , Bénédicte Desforges , Vandana Joshi , Mirela Boca , Dmitry Kretov
Journal of Cell Science, 2018, 131 (11), pp.jcs214692. ⟨10.1242/jcs.214692⟩
Journal articles hal-02166855v1

Vectofusin-1, a potent peptidic enhancer of viral gene transfer forms pH-dependent α-helical nanofibrils, concentrating viral particles

Louic Vermeer , Loic Hamon , Alicia Schirer , Michel Schoup , Jérémie Cosette
Acta Biomaterialia, 2017, 64, pp.259-268. ⟨10.1016/j.actbio.2017.10.009⟩
Journal articles hal-02174366v1

Nanoscale Analysis Reveals the Maturation of Neurodegeneration-Associated Protein Aggregates

Sanae Abrakhi , Dmitry Kretov , Bénédicte Desforges , Ioana Dobra , Ahmed Bouhss
ACS Nano, 2017, 11 (7), pp.7189-7200. ⟨10.1021/acsnano.7b03071⟩
Journal articles hal-02173623v1
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Single molecule detection of PARP1 and PARP2 interaction with DNA strand breaks and their poly(ADP-ribosyl)ation using high-resolution AFM imaging

Maria Sukhanova , Sanae Abrakhi , Vandana Joshi , David Pastre , Mikhail Kutuzov
Nucleic Acids Research, 2016, 44 (6), pp.e60-e60. ⟨10.1093/nar/gkv1476⟩
Journal articles hal-02183571v1

Polyamine signal through gap junctions : A key regulator of proliferation and gap-junction organization in mammalian tissues ?

Loic Hamon , Philippe Savarin , David Pastre
BioEssays, 2016, 38 (6), pp.498-507. ⟨10.1002/bies.201500195⟩
Journal articles hal-02174559v1
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Role of tau in the spatial organization of axonal microtubules: keeping parallel microtubules evenly distributed despite macromolecular crowding

Alix Méphon-Gaspard , Mirela Boca , Catherine Pioche-Durieu , Bénédicte Desforges , Andrea Burgo
Cellular and Molecular Life Sciences, 2016, 73 (19), pp.3745-3760. ⟨10.1007/s00018-016-2216-z⟩
Journal articles hal-02183396v1
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mRNA and DNA selection via protein multimerization: YB-1 as a case study

Dmitry Kretov , Patrick A. Curmi , Loic Hamon , Sanae Abrakhi , Bénédicte Desforges
Nucleic Acids Research, 2015, 43 (19), pp.9457-9473. ⟨10.1093/nar/gkv822⟩
Journal articles hal-02183823v1
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Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules

Ouissame Bounedjah , Bénédicte Desforges , Ting-Di Wu , Catherine Pioche-Durieu , Sergio Marco
Nucleic Acids Research, 2014, 42 (13), pp.8678-8691. ⟨10.1093/nar/gku582⟩
Journal articles hal-02292175v1

Detection of Single DNA Molecule Hybridization on a Surface by Atomic Force Microscopy

David Pastre , Vandana Joshi , Patrick Curmi , Loic Hamon
Small, 2013, 9 (21), pp.3630-3638. ⟨10.1002/smll.201300546⟩
Journal articles hal-02291850v1
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An intercellular polyamine transfer via gap junctions regulates proliferation and response to stress in epithelial cells

Bénédicte Desforges , Patrick Curmi , Ouissame Bounedjah , Samir Nakib , Loic Hamon
Molecular Biology of the Cell, 2013, 24 (10), pp.1505-1613. ⟨10.1091/mbc.E12-10-0729⟩
Journal articles hal-02292186v1
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Structural Basis for the Association of MAP6 Protein with Microtubules and Its Regulation by Calmodulin

Julien Lefèvre , Philippe Savarin , Pierre Gans , Loïc Hamon , Marie-Jeanne Clément
Journal of Biological Chemistry, 2013, 288 (34), pp.24910-24922. ⟨10.1074/jbc.M113.457267⟩
Journal articles inserm-00858655v1

Effect of the multifunctional proteins RPA, YB-1, and XPC repair factor on AP site cleavage by DNA glycosylase NEIL1

Pavel Pestryakov , Dmitry Zharkov , Inga Grin , Elizaveta Fomina , Ekaterina Kim
Journal of Molecular Recognition, 2012, 25 (4), pp.224-233. ⟨10.1002/jmr.2182⟩
Journal articles hal-02292246v1

Macromolecular Crowding Regulates Assembly of mRNA Stress Granules after Osmotic Stress

Ouissame Bounedjah , Loic Hamon , Philippe Savarin , Bénédicte Desforges , Patrick Curmi
Journal of Biological Chemistry, 2012, 287 (4), pp.2446-2458. ⟨10.1074/jbc.M111.292748⟩
Journal articles hal-02292253v1

Rapid Assembly and Collective Behavior of Microtubule Bundles in the Presence of Polyamines

Loic Hamon , Philippe Savarin , Patrick a. Curmi , David Pastre
Biophysical Journal, 2011, 101 (1), pp.205-216. ⟨10.1016/j.bpj.2011.05.022⟩
Journal articles hal-02292262v1

Gap junctions favor normal rat kidney epithelial cell adaptation to chronic hypertonicity

Bénédicte Desforges , Philippe Savarin , Ouissame Bounedjah , Stephanie Delga , Loic Hamon
American Journal of Physiology - Cell Physiology, 2011, 301 (3), pp.C705-C716. ⟨10.1152/ajpcell.00128.2011⟩
Journal articles hal-02292290v1
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A Central Role for Polyamines in Microtubule Assembly in Cells

Philippe Savarin , Aurélie Barbet , Stephanie Delga , Vandana Joshi , Loic Hamon
Biochemical Journal, 2010, 430 (1), pp.151-159. ⟨10.1042/BJ20091811⟩
Journal articles hal-00506521v1

Specific DNA−Protein Interactions on Mica Investigated by Atomic Force Microscopy

David Pastré , Loic Hamon , Isabelle Sorel , Eric Le Cam , Patrick Curmi
Langmuir, 2010, 26 (4), pp.2618-2623. ⟨10.1021/la902727b⟩
Journal articles hal-02293295v1

The Stathmin-Derived I19L Peptide Interacts with FtsZ and Alters Its Bundling

Marie-Jeanne Clément , Boï-Trinh Kuoch , Tâp Ha-Duong , Vandana Joshi , Loic Hamon
Biochemistry, 2009, 48 (41), pp.9734-9744. ⟨10.1021/bi900556a⟩
Journal articles hal-02295213v1
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Polyamine sharing between tubulin dimers favours microtubule nucleation and elongation via facilitated diffusion

Alain Mechulam , Konstantin G. Chernov , Elodie Mucher , Loic Hamon , Patrick A. Curmi
PLoS Computational Biology, 2009, 5 (1), pp.e1000255. ⟨10.1371/journal.pcbi.1000255⟩
Journal articles inserm-00705780v1

Role of Microtubules in Stress Granule Assembly

Konstantin G. Chernov , Aurélie Barbet , Loic Hamon , Lev Ovchinnikov , Patrick Curmi
Journal of Biological Chemistry, 2009, 284 (52), pp.36569-36580. ⟨10.1074/jbc.M109.042879⟩
Journal articles hal-02295275v1

Mica Surface Promotes the Assembly of Cytoskeletal Proteins

Loic Hamon , Dulal Panda , Philippe Savarin , Vandana Joshi , Johann Bernhard
Langmuir, 2009, 25 (6), pp.3331-3335. ⟨10.1021/la8035743⟩
Journal articles hal-02294800v1

Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB-1 and PABP

Konstantin G. Chernov , Patrick Curmi , Loic Hamon , Alain Mechulam , Lev Ovchinnikov
FEBS Letters, 2008, 582 (19), pp.2875-2881. ⟨10.1016/j.febslet.2008.07.019⟩
Journal articles hal-02295333v1
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High-resolution AFM imaging of single-stranded DNA-binding (SSB) protein--DNA complexes

L. Hamon , D. Pastré , P. Dupaigne , C. Breton , E. Cam
Nucleic Acids Research, 2007, 35 (8), pp.e58-e58. ⟨10.1093/nar/gkm147⟩
Journal articles hal-02295472v1

Atomic Force Microscopy Imaging of DNA under Macromolecular Crowding Conditions

David Pastre , Loic Hamon , Alain Mechulam , Isabelle Sorel , Sonia Baconnais
Biomacromolecules, 2007, 8 (12), pp.3712-3717. ⟨10.1021/bm700856u⟩
Journal articles hal-02295397v1

Anionic Polyelectrolyte Adsorption on Mica Mediated by Multivalent Cations: A Solution to DNA Imaging by Atomic Force Microscopy under High Ionic Strengths

David Pastre , Loic Hamon , Fabrice Landousy , Isabelle Sorel , Marie-Odile David
Langmuir, 2006, 22 (15), pp.6651-6660. ⟨10.1021/la053387y⟩
Journal articles hal-03065293v1

The EcoRI−DNA Complex as a Model for Investigating Protein−DNA Interactions by Atomic Force Microscopy

Isabelle Sorel , Olivier Piétrement , Loic Hamon , Sonia Baconnais , Eric Le Cam
Biochemistry, 2006, 45 (49), pp.14675-14682. ⟨10.1021/bi060293u⟩
Journal articles hal-03065288v1

A new approach to DNA bending by polyamines and its implication in DNA condensation

David Pastre , Olivier Piétrement , Fabrice Landousy , Loic Hamon , Isabelle Sorel
European Biophysics Journal, 2006, 35 (3), pp.214-223. ⟨10.1007/s00249-005-0025-7⟩
Journal articles hal-03065301v1

Studying the effect of a charged surface on the interaction of bleomycin with DNA using an atomic force microscope

Olivier Piétrement , David Pastre , Fabrice Landousy , Marie-Odile David , Stéphane Fusil
European Biophysics Journal, 2005, 34 (3), pp.200-207. ⟨10.1007/s00249-004-0443-y⟩
Journal articles hal-03065310v1

Adsorption of DNA to Mica Mediated by Divalent Counterions: A Theoretical and Experimental Study

David Pastre , Olivier Piétrement , Stéphane Fusil , Fabrice Landousy , Josette Jeusset
Biophysical Journal, 2003, 85 (4), pp.2507-2518. ⟨10.1016/s0006-3495(03)74673-6⟩
Journal articles hal-03065312v1

Reversible Binding of DNA on NiCl 2 -Treated Mica by Varying the Ionic Strength

Olivier Piétrement , David Pastre , Stéphane Fusil , Josette Jeusset , Marie-Odile David
Langmuir, 2003, 19 (7), pp.2536-2539. ⟨10.1021/la026942u⟩
Journal articles hal-03065317v1

Thickness dependence of the glass transition temperature in thin films of partially miscible polymer blends.

L. Hamon , Y. Grohens , Y. Holl
Langmuir, 2003, 19, pp.10399-10402
Journal articles hal-00188278v1