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Presentation ResearcherID : E-1627-2011 ------------------------------------------------------------------ Group leader in Biochemistry, Molecular Biology, Drug Design at CEA Saclay / DRF / Joliot institute / DMTS / SIMoS


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Isotope imaging of ultra-traces by LA-fs HR-ICP-MS for U-series dating (U/Th) of archaeological biominerals: how far can we go?

Asmodée Galy , Loïc M Martin , Fanny Claverie , Edwige Pons-Branchu , Chantal Tribolo
Journal of Physics: Conference Series, 2022, 2204, pp.012017. ⟨10.1088/1742-6596/2204/1/012017⟩
Journal articles hal-03689525v1
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Dose-Rate Estimation using alpha-Al2O3:C Chips: Aftermath

Sebastian Kreutzer , Chantal Tribolo , Loïc M Martin , Norbert Mercier
Ancient TL, 2020, 38 (1), pp.1-10
Journal articles hal-02897823v1
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Effect of natural organic matter on thallium and silver speciation

Loïc M Martin , Caroline Simonucci , Sétareh Rad , Marc F. Benedetti
Journal of Environmental Sciences, 2020, 93, pp.185-192. ⟨10.1016/j.jes.2020.04.001⟩
Journal articles hal-02565435v1

Evolution of the Envelope Glycoprotein of HIV-1 Clade B toward Higher Infectious Properties over the Course of the Epidemic

Mélanie Bouvin-Pley , Maxime Beretta , Moreau Alain , Emmanuelle Roch , Asma Essat
Journal of Virology, 2019, 93 (6), 15 p. ⟨10.1128/JVI.01171-18⟩
Journal articles hal-02531055v1

Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer

Peng Zhang , Jason Gorman , Hui Geng , Qingbo Liu , Yin Lin
Cell Host and Microbe, 2018, 23 (6), pp.832-844.e6. ⟨10.1016/j.chom.2018.05.002⟩
Journal articles hal-02531048v1

Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques

Xiaoying Shen , Willy Bogers , Nicole Yates , Guido Ferrari , Antu Dey
Journal of Virology, 2017, 91 (19), ⟨10.1128/JVI.00401-17⟩
Journal articles hal-02530935v1

Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region

William Tolbert , Neelakshi Gohain , Nirmin Alsahafi , Verna Van , Chiara Orlandi
Structure, 2017, 25 (11), pp.1719-1731.e4. ⟨10.1016/j.str.2017.09.009⟩
Journal articles hal-02531052v1

M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures

Giuseppina Musumeci , Isabella Bon , David Lembo , Valeria Cagno , Maria Carla Re
Scientific Reports, 2017, 7 (1), ⟨10.1038/srep41018⟩
Journal articles hal-02530919v1

Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site

Willy Bogers , Susan W Barnett , Herman Oostermeijer , Ivonne Nieuwenhuis , Niels Beenhakker
Journal of Virology, 2017, 91 (19), ⟨10.1128/JVI.00811-17⟩
Journal articles hal-02530939v1

Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins

Jonathan Richard , Beatriz Pacheco , Neelakshi Gohain , Maxime Veillette , Shilei Ding
EBioMedicine, 2016, 12, pp.208-218. ⟨10.1016/j.ebiom.2016.09.004⟩
Journal articles hal-02530909v1

Thermosensitive and Mucoadhesive Pluronic-Hydroxypropylmethylcellulose Hydrogel Containing the Mini-CD4 M48U1 Is a Promising Efficient Barrier against HIV Diffusion through Macaque Cervicovaginal Mucus

Kawthar Bouchemal , Armelle Aka-Any-Grah , Nathalie Dereuddre-Bosquet , Loïc M Martin , Vanessa Lievin-Le-Moal
Antimicrobial Agents and Chemotherapy, 2015, 59 (4), pp.2215-2222. ⟨10.1128/AAC.03503-14⟩
Journal articles cea-02530843v1

Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1

Neelakshi Gohain , William Tolbert , Priyamvada Acharya , Lei Yu , Tongyun Liu
Journal of Virology, 2015, 89 (17), pp.8840-8854. ⟨10.1128/JVI.01232-15⟩
Journal articles hal-02530901v1

Trimeric HIV Env provides epitope occlusion mediated by hypervariable loops

Carlos Moscoso , Li Xing , Jinwen Hui , Jeffrey Hu , Mohammad Baikoghli Kalkhoran
Scientific Reports, 2015, 4 (1), ⟨10.1038/srep07025⟩
Journal articles cea-02530807v1

CD4 mimetics sensitize HIV-1-infected cells to ADCC

Jonathan Richard , Maxime Veillette , Nathalie Brassard , Shilpa Iyer , Michel Roger
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (20), pp.E2687-E2694. ⟨10.1073/pnas.1506755112⟩
Journal articles hal-02530884v1
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Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas

Hannah Barbian , Julie Decker , Frederic Bibollet-Ruche , Rachel Galimidi , Anthony West
mBio, 2015, 6 (2), ⟨10.1128/mBio.00296-15⟩
Journal articles cea-02530869v1

Combinations of Entry and Reverse Transcriptase Inhibitors as Candidate Microbicides

Carolina Herrera , Natalia Olejniczak , Javier García Pérez , Jose Alcami , Loïc M Martin
AIDS Research and Human Retroviruses, 2014, 30 (S1), pp.A213-A213. ⟨10.1089/aid.2014.5461.abstract⟩
Journal articles hal-02542966v1

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

P. Acharya , W. Tolbert , N. Gohain , X. Wu , Linwen Yu
Journal of Virology, 2014, 88 (21), pp.12895-12906. ⟨10.1128/JVI.02194-14⟩
Journal articles cea-02530781v1

M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

Philippe Selhorst , Katrijn Grupping , Tommy Tong , Ema Crooks , Loïc M Martin
Retrovirology, 2013, 10 (1), pp.12. ⟨10.1186/1742-4690-10-12⟩
Journal articles hal-02542962v1

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

P. Acharya , T. Luongo , I. Georgiev , J. Matz , S. Schmidt
Journal of Virology, 2013, 87 (18), pp.10173-10181. ⟨10.1128/JVI.01332-13⟩
Journal articles hal-02530765v1

Interfacial Cavity Filling To Optimize CD4–Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein

Laurence Morellato-Castillo , Priyamvada Acharya , Olivier Combes , Johan Michiels , Anne Descours
Journal of Medicinal Chemistry, 2013, 56 (12), pp.5033-5047. ⟨10.1021/jm4002988⟩
Journal articles hal-02530667v1

Note on the formulation of thermosensitive and mucoadhesive vaginal hydrogels containing the miniCD4 M48U1 as anti-HIV-1 microbicide

Kawthar Bouchemal , Justyna Frelichowska , Loïc M Martin , Vanessa Liévin-Le Moal , Roger Le Grand
International Journal of Pharmaceutics, 2013, 454 (2), pp.649-652. ⟨10.1016/j.ijpharm.2013.02.055⟩
Journal articles hal-02530642v1

Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1

Priyamvada Acharya , Timothy S. Luongo , Mark k. Louder , Krisha Mckee , Yongping Yang
Structure, 2013, 21 (6), pp.1018-1029. ⟨10.1016/j.str.2013.04.015⟩
Journal articles hal-02530653v1
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Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and co-receptor binding sites of HIV-1 gp120

Julie Matz , Pacal Kessler , Jérome Bouchet , Olivier Combes , Daniel Baty
Retrovirology, 2012, 9 (Suppl 2), pp.P214
Journal articles inserm-00731772v1

MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency

Katrijn Grupping , Philippe Selhorst , Johan Michiels , Katleen Vereecken , Leo Heyndrickx
Retrovirology, 2012, 9 (1), pp.36. ⟨10.1186/1742-4690-9-36⟩
Journal articles cea-02530546v1

Straightforward Selection of Broadly Neutralizing Single-Domain Antibodies Targeting the Conserved CD4 and Coreceptor Binding Sites of HIV-1 gp120

J. Matz , P. Kessler , J. Bouchet , O. Combes , O. Ramos
Journal of Virology, 2012, 87 (2), pp.1137-1149. ⟨10.1128/JVI.00461-12⟩
Journal articles cea-02530610v1

Elicitation of Neutralizing Antibodies Directed against CD4-Induced Epitope(s) Using a CD4 Mimetic Cross-Linked to a HIV-1 Envelope Glycoprotein

Antu Dey , Brian Burke , Yide Sun , Klara Sirokman , Avishek Nandi
PLoS ONE, 2012, 7 (1), pp.e30233. ⟨10.1371/journal.pone.0030233⟩
Journal articles cea-02530537v1
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Structural definition of a novel CD4-induced epitope that is targeted by a single-headed immunoglobulin to effect broad and potent HIV neutralization

Priyamvada Acharya , Timothy S. Luongo , Julie Matz , Stephen D. Schmidt , Gwo-Yu Chuang
Retrovirology, 2012, 9 (Suppl 2), pp.P346
Journal articles inserm-00731776v1

MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV162P3 in Cynomolgus Macaques

Nathalie Dereuddre-Bosquet , Laurence Morellato-Castillo , Joachim Brouwers , Patrick Augustijns , Kawthar Bouchemal
PLoS Pathogens, 2012, 8 (12), pp.e1003071. ⟨10.1371/journal.ppat.1003071⟩
Journal articles cea-02530573v1

RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans

N. Suffee , H. Hlawaty , A. Meddahi-Pelle , L. Maillard , L. Louedec
Angiogenesis, 2012, 15 (4), pp.727-744. ⟨10.1007/s10456-012-9285-x⟩
Journal articles cea-02530559v1

Structure-Based Identification and Neutralization Mechanism of Tyrosine Sulfate Mimetics That Inhibit HIV-1 Entry

Priyamvada Acharya , Cajetan Dogo-Isonagie , Judith Lalonde , Son Lam , George Leslie
ACS Chemical Biology, 2011, 6 (10), pp.1069-1077. ⟨10.1021/cb200068b⟩
Journal articles cea-02530519v1

Quaternary structures of HIV Env immunogen exhibit conformational vicissitudes and interface diminution elicited by ligand binding

C. Moscoso , Y. Sun , S. Poon , L. Xing , E. Kan
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (15), pp.6091-6096. ⟨10.1073/pnas.1016113108⟩
Journal articles cea-02530515v1

Stabilization of HIV-1 Envelope in the CD4-bound Conformation through Specific Cross-linking of a CD4 Mimetic

Grégoire Martin , Brian Burke , Robert Thai , Antu Dey , Olivier Combes
Journal of Biological Chemistry, 2011, 286 (24), pp.21706-21716
Journal articles cea-01989703v1

Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells

Maylis Dagouassat , Nadine Suffee , Hanna Hlawaty , Oualid Haddad , Faten Charni
International Journal of Cancer, 2010, 126 (5), pp.1095-1108. ⟨10.1002/ijc.24800⟩
Journal articles cea-02529147v1
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A global benchmark study using affinity-based biosensors

Rebecca L. Rich , Giuseppe A. Papalia , Peter J. Flynn , Jamie Furneisen , John Quinn
Analytical Biochemistry, 2009, 386 (2), pp.194-216. ⟨10.1016/j.ab.2008.11.021⟩
Journal articles hal-01527917v1

P19-23. Putative prefusion mechanism of HIV-1 Env revealed by ligand-induced quaternary alterations in o-gp140 trimers

Cg Moscoso , E Kan , S Poon , Y. Sun , Loïc M Martin
Retrovirology, 2009, 6 (Suppl 3), pp.P343. ⟨10.1186/1742-4690-6-S3-P343⟩
Journal articles hal-02542974v1

Structural Studies of the Complex Between Akt-in and the Akt2-PH Domain Suggest that the Peptide Acts as an Allosteric Inhibitor of the Akt Kinase

Virginie Ropars , Philippe Barthe , Chi-Shien Wang , Wenlung Chen , Der-Lii Tzou
The Open Spectroscopy Journal, 2009, 3 (1), pp.65-76. ⟨10.2174/1874383800903010065⟩
Journal articles hal-02543033v1

Syndecan-1 and syndecan-4 are involved in RANTES/CCL5-induced migration and invasion of human hepatoma cells

Faten Charni , Véronique Friand , Oualid Haddad , Hanna Hlawaty , Loïc M Martin
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009, 1790 (10), pp.1314-1326. ⟨10.1016/j.bbagen.2009.07.015⟩
Journal articles cea-02529135v1

Resistance to the CD4 mimetic mini protein M48-U1 induces changes in a highly conserved region on the HIV-1 gp120 envelope protein

K Grupping , L. Heyndrickx , J. Michiels , G. Martin , Loïc M Martin
Retrovirology, 2009, 6 (S3-P12-11), ⟨10.1186/1742-4690-6-S3-P177⟩
Journal articles hal-02542981v1

A simple one-step method for the preparation of HIV-1 envelope glycoprotein immunogens based on a CD4 mimic peptide

Grégoire Martin , Yide Sun , Bernadette Heyd , Olivier Combes , Jeffrey Ulmer
Virology, 2008, 381 (2), pp.241-250. ⟨10.1016/j.virol.2008.08.039⟩
Journal articles hal-02528592v1

Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein

François Stricher , Chih-Chin Huang , Anne Descours , Sophie Duquesnoy , Olivier Combes
Journal of Molecular Biology, 2008, 382 (2), pp.510-524. ⟨10.1016/j.jmb.2008.06.069⟩
Journal articles hal-02528576v1

Glycosaminoglycans and their synthetic mimetics inhibit RANTES-induced migration and invasion of human hepatoma cells.

Angela Sutton , Veronique Friand , Dulce Papy-Garcia , Maylis Dagouassat , Loïc M Martin
Molecular Cancer Therapeutics, 2007, 6 (11), pp.2948-58. ⟨10.1158/1535-7163.MCT-07-0114⟩
Journal articles hal-00195453v1

A high-throughput fluorescence polarization assay specific to the CD4 binding site of HIV-1 glycoproteins based on a fluorescein-labelled CD4 mimic

François Stricher , Loïc M Martin , Philippe Barthe , Vivian Pogenberg , Alain Mechulam
Biochemical Journal, 2005, 390 (1), pp.29-39. ⟨10.1042/BJ20041953⟩
Journal articles hal-02528566v1

Scorpion-Toxin Mimics of CD4 in Complex with Human Immunodeficiency Virus gp120

Chih-Chin Huang , François Stricher , Loïc M Martin , Julie Decker , Shahzad Majeed
Structure, 2005, 13 (5), pp.755-768. ⟨10.1016/j.str.2005.03.006⟩
Journal articles hal-02528561v1

Crystal Structure of the Broadly Cross-Reactive HIV-1-Neutralizing Fab X5 and Fine Mapping of Its Epitope † , ‡

Ramalakshmi Darbha , Sanjay Phogat , Aran Labrijn , Yuuei Shu , Yijun Gu
Biochemistry, 2004, 43 (6), pp.1410-1417. ⟨10.1021/bi035323x⟩
Journal articles hal-02543015v1

Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes

Loïc M Martin , François Stricher , Dorothée Missé , Francesca Sironi , Martine Pugnière
Nature Biotechnology, 2003, 21 (1), pp.71-76. ⟨10.1038/nbt768⟩
Journal articles hal-02528557v1

Synthesis and characterization of biologically functional biotinylated RANTES

Claudio Vita , Eugenia Drakopoulou , Loyda Ylisastigui , Youssef Bakri , Jean Vizzavona
Journal of Immunological Methods, 2002, 266 (1-2), pp.53-65. ⟨10.1016/s0022-1759(02)00096-0⟩
Journal articles hal-02528550v1

Heparin-aggregated RANTES can be crystallised.

Enrico A Stura , Loïc M Martin , Hugues Lortat-Jacob , Romain R Vivès , Claudio Vita
Acta crystallographica Section D : Structural biology [1993-..], 2002, 58 (Pt 10 Pt 1), pp.1670-3
Journal articles hal-01061424v1

Role of Disulfide Bonds in Folding and Activity of Leiurotoxin I: Just Two Disulfides Suffice

Qi Zhu , Songping Liang , Loïc M Martin , Sylvaine Gasparini , André Ménez
Biochemistry, 2002, 41 (38), pp.11488-11494. ⟨10.1021/bi026136m⟩
Journal articles hal-02528546v1

Solid-phase synthesis of peptides containing the spin-labeled 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid (TOAC)

Loïc M Martin , C. Vita , A. Ivancich , F. Formaggio , C. Toniolo
Journal of Peptide Research, 2001, 58 (5), pp.424-432. ⟨10.1034/j.1399-3011.2001.00940.x⟩
Journal articles hal-02543003v1

Structural and Functional Analysis of the RANTES-Glycosaminoglycans Interactions

Loïc M Martin , Cédric Blanpain , Pascale Garnier , Valérie Wittamer , Marc Parmentier
Biochemistry, 2001, 40 (21), pp.6303-6318. ⟨10.1021/bi002670n⟩
Journal articles hal-02528544v1

Engineering Novel Bioactive Mini-Proteins on Natural Scaffolds

Loïc M Martin , Philipe Barthe , Olivier Combes , Christian Roumestand , Claudio Vita
Tetrahedron, 2000, 56 (48), pp.9451-9460. ⟨10.1016/S0040-4020(00)00829-2⟩
Journal articles hal-02528540v1

Engineering Novel Bioactive Mini-Proteins from Small Size Natural and De Novo Designed Scaffolds

Loïc M Martin , Claudio Vita
Current Protein and Peptide Science, 2000, 1 (4), pp.403-430. ⟨10.2174/1389203003381306⟩
Journal articles hal-02543052v1

Metallopeptidase Inhibitors of Tetanus Toxin: A Combinatorial Approach

Loïc M Martin , Fabrice Cornille , Serge Turcaud , Hervé Meudal , Bernard P. Roques
Journal of Medicinal Chemistry, 1999, 42 (3), pp.515-525. ⟨10.1021/jm981066w⟩
Journal articles hal-02528535v1

β-Amino-thiols Inhibit the Zinc Metallopeptidase Activity of Tetanus Toxin Light Chain

Loïc M Martin , Fabrice Cornille , Pascale Coric , Bernard P. Roques , Marie-Claude Fournie-Zaluski
Journal of Medicinal Chemistry, 1998, 41 (18), pp.3450-3460. ⟨10.1021/jm981015z⟩
Journal articles hal-02461413v1

Allosteric-type control of synaptobrevin cleavage by tetanus toxin light chain

Fabrice Cornille , Loïc M Martin , Christine Lenoir , Didier Cussac , Bernard P. Roques
Letters in Peptide Science, 1997, 4 (4-6), pp.207-212. ⟨10.1007/BF02442877⟩
Journal articles hal-02528513v1

2,4-Dinitrophenyl 4-Methoxybenzyl Disulfide: A New Efficient Reagent for the Electrophilic Sulfenylation of β-Amino Ester Enolates

Laurent Bischoff , Christelle David , Loïc M Martin , Hervé Meudal , Bernard-Pierre Roques
Journal of Organic Chemistry, 1997, 62 (14), pp.4848-4850. ⟨10.1021/jo9623853⟩
Journal articles hal-02122111v1
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Cooperative Exosite-dependent Cleavage of Synaptobrevin by Tetanus Toxin Light Chain

Fabrice Cornille , Loïc M Martin , Christine Lenoir , Didier Cussac , Bernard P. Roques
Journal of Biological Chemistry, 1997, 272 (6), pp.3459-3464. ⟨10.1074/jbc.272.6.3459⟩
Journal articles hal-02528515v1

A Sensitive and Rapid Fluorescence-Based Assay for Determination of Tetanus Toxin Peptidase Activity

Jean-Marc Soleilhac , Fabrice Cornille , Loïc M Martin , Christine Lenoir , Marie-Claude Fournié-Zaluski
Analytical Biochemistry, 1996, 241 (1), pp.120-127. ⟨10.1006/abio.1996.0385⟩
Journal articles hal-02528509v1

Design of Miniproteins by the Transfer of Active Sites Onto Small-Size Scaffolds

François Stricher , Loïc M Martin , Claudio Vita
Protein Design, 340, Humana Press, pp.113-150, 2006, Part of the Methods in Molecular Biology book series (MIMB, volume 340), ⟨10.1385/1-59745-116-9:113⟩
Book sections hal-02528572v1