Loic MARTIN

Présentation

https://orcid.org/0000-0002-7940-2955 ResearcherID : E-1627-2011

Group leader in Biochemistry, Molecular Biology, Drug Design at CEA Saclay / DRF / Joliot institute / DMTS / SIMoS

Publications

Article dans une revue (55)

Evolution of the Envelope Glycoprotein of HIV-1 Clade B toward Higher Infectious Properties over the Course of the Epidemic Mélanie Bouvin-Pley,Maxime Beretta,Moreau Alain,Emmanuelle Roch,Asma Essatet al. Journal of Virology, 2019, 93 (6), 15 p. ⟨10.1128/JVI.01171-18⟩ Article dans une revue hal-02531055v1
Interdomain stabilization impairs CD4 binding and improves immunogenicity of the HIV-1 envelope trimer Peng Zhang,Jason Gorman,Hui Geng,Qingbo Liu,Yin Linet al. Cell Host and Microbe, 2018, 23 (6), pp.832-844.e6. ⟨10.1016/j.chom.2018.05.002⟩ Article dans une revue hal-02531048v1
M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures Giuseppina Musumeci,Isabella Bon,David Lembo,Valeria Cagno,Maria Carla Reet al. Scientific Reports, 2017, 7 (1), ⟨10.1038/srep41018⟩ Article dans une revue hal-02530919v1
Targeting the late stage of HIV-1 entry for antibody-dependent cellular cytotoxicity: structural basis for Env epitopes in the C11 region William Tolbert,Neelakshi Gohain,Nirmin Alsahafi,Verna Van,Chiara Orlandiet al. Structure, 2017, 25 (11), pp.1719-1731.e4. ⟨10.1016/j.str.2017.09.009⟩ Article dans une revue hal-02531052v1
Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques Xiaoying Shen,Willy Bogers,Nicole Yates,Guido Ferrari,Antu Deyet al. Journal of Virology, 2017, 91 (19), ⟨10.1128/JVI.00401-17⟩ Article dans une revue hal-02530935v1
Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site Willy Bogers,Susan W Barnett,Herman Oostermeijer,Ivonne Nieuwenhuis,Niels Beenhakkeret al. Journal of Virology, 2017, 91 (19), ⟨10.1128/JVI.00811-17⟩ Article dans une revue hal-02530939v1
Co-receptor binding site antibodies enable CD4-mimetics to expose conserved anti-cluster A ADCC epitopes on HIV-1 envelope glycoproteins Jonathan Richard,Beatriz Pacheco,Neelakshi Gohain,Maxime Veillette,Shilei Dinget al. EBioMedicine, 2016, 12, pp.208-218. ⟨10.1016/j.ebiom.2016.09.004⟩ Article dans une revue hal-02530909v1
CD4 mimetics sensitize HIV-1-infected cells to ADCC Jonathan Richard,Maxime Veillette,Nathalie Brassard,Shilpa Iyer,Michel Rogeret al. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (20), pp.E2687-E2694. ⟨10.1073/pnas.1506755112⟩ Article dans une revue hal-02530884v1
Trimeric HIV Env provides epitope occlusion mediated by hypervariable loops Carlos G. Moscoso,Li Xing,Jinwen Hui,Jeffrey Hu,Mohammad Baikoghli Kalkhoranet al. Scientific Reports, 2015, 4, pp.7025. ⟨10.1038/srep07025⟩ Article dans une revue cea-02530807v1
Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1 Neelakshi Gohain,William Tolbert,Priyamvada Acharya,Lei Yu,Tongyun Liuet al. Journal of Virology, 2015, 89 (17), pp.8840-8854. ⟨10.1128/JVI.01232-15⟩ Article dans une revue hal-02530901v1
Thermosensitive and mucoadhesive pluronic-hydroxypropylmethylcellulose hydrogel containing the mini-CD4 M48U1 Is a promising efficient barrier against HIV diffusion through macaque Cervicovaginal Mucus Kawthar Bouchemal,Armelle Aka-Any-Grah,Nathalie Dereuddre-Bosquet,Loïc M Martin,Vanessa Lievin-Le-Moalet al. Antimicrobial Agents and Chemotherapy, 2015, 59 (4), pp.2215-2222. ⟨10.1128/AAC.03503-14⟩ Article dans une revue cea-02530843v1
Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas Hannah Barbian,Julie Decker,Frederic Bibollet-Ruche,Rachel Galimidi,Anthony Westet al. mBio, 2015, 6 (2), ⟨10.1128/mBio.00296-15⟩ Article dans une revue cea-02530869v1
Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection P. Acharya,W. Tolbert,N. Gohain,X. Wu,Linwen Yuet al. Journal of Virology, 2014, 88 (21), pp.12895-12906. ⟨10.1128/JVI.02194-14⟩ Article dans une revue cea-02530781v1
Combinations of Entry and Reverse Transcriptase Inhibitors as Candidate Microbicides Carolina Herrera,Natalia Olejniczak,Javier García Pérez,Jose Alcami,Loïc M Martinet al. AIDS Research and Human Retroviruses, 2014, 30 (S1), pp.A213-A213. ⟨10.1089/aid.2014.5461.abstract⟩ Article dans une revue hal-02542966v1
M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding Philippe Selhorst,Katrijn Grupping,Tommy Tong,Ema Crooks,Loïc M Martinet al. Retrovirology, 2013, 10 (1), pp.12. ⟨10.1186/1742-4690-10-12⟩ Article dans une revue hal-02542962v1
Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1 Priyamvada Acharya,Timothy S. Luongo,Mark k. Louder,Krisha Mckee,Yongping Yanget al. Structure, 2013, 21 (6), pp.1018-1029. ⟨10.1016/j.str.2013.04.015⟩ Article dans une revue hal-02530653v1
Interfacial Cavity Filling To Optimize CD4–Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein Laurence Morellato-Castillo,Priyamvada Acharya,Olivier Combes,Johan Michiels,Anne Descourset al. Journal of Medicinal Chemistry, 2013, 56 (12), pp.5033-5047. ⟨10.1021/jm4002988⟩ Article dans une revue hal-02530667v1
Note on the formulation of thermosensitive and mucoadhesive vaginal hydrogels containing the miniCD4 M48U1 as anti-HIV-1 microbicide Kawthar Bouchemal,Justyna Frelichowska,Loïc M Martin,Vanessa Liévin-Le Moal,Roger Le Grandet al. International Journal of Pharmaceutics, 2013, 454 (2), pp.649-652. ⟨10.1016/j.ijpharm.2013.02.055⟩ Article dans une revue istex hal-02530642v1
Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites P. Acharya,T. Luongo,I. Georgiev,J. Matz,S. Schmidtet al. Journal of Virology, 2013, 87 (18), pp.10173-10181. ⟨10.1128/JVI.01332-13⟩ Article dans une revue hal-02530765v1
Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and co-receptor binding sites of HIV-1 gp120 Julie Matz,Pacal Kessler,Jérome Bouchet,Olivier Combes,Daniel Batyet al. Retrovirology, 2012, 9 (Suppl 2), pp.P214 Article dans une revue inserm-00731772v1
RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans N. Suffee,H. Hlawaty,A. Meddahi-Pelle,L. Maillard,L. Louedecet al. Angiogenesis, 2012, 15 (4), pp.727-744. ⟨10.1007/s10456-012-9285-x⟩ Article dans une revue istex cea-02530559v1
MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV162P3 in Cynomolgus Macaques Nathalie Dereuddre-Bosquet,Laurence Morellato-Castillo,Joachim Brouwers,Patrick Augustijns,Kawthar Bouchemalet al. PLoS Pathogens, 2012, 8 (12), pp.e1003071. ⟨10.1371/journal.ppat.1003071⟩ Article dans une revue cea-02530573v1
Structural definition of a novel CD4-induced epitope that is targeted by a single-headed immunoglobulin to effect broad and potent HIV neutralization Priyamvada Acharya,Timothy S. Luongo,Julie Matz,Stephen D. Schmidt,Gwo-Yu Chuanget al. Retrovirology, 2012, 9 (Suppl 2), pp.P346 Article dans une revue inserm-00731776v1
MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency Katrijn Grupping,Philippe Selhorst,Johan Michiels,Katleen Vereecken,Leo Heyndrickxet al. Retrovirology, 2012, 9 (1), pp.36. ⟨10.1186/1742-4690-9-36⟩ Article dans une revue cea-02530546v1
Straightforward Selection of Broadly Neutralizing Single-Domain Antibodies Targeting the Conserved CD4 and Coreceptor Binding Sites of HIV-1 gp120 J. Matz,P. Kessler,J. Bouchet,O. Combes,O. Ramoset al. Journal of Virology, 2012, 87 (2), pp.1137-1149. ⟨10.1128/JVI.00461-12⟩ Article dans une revue cea-02530610v1
Elicitation of Neutralizing Antibodies Directed against CD4-Induced Epitope(s) Using a CD4 Mimetic Cross-Linked to a HIV-1 Envelope Glycoprotein Antu Dey,Brian Burke,Yide Sun,Klara Sirokman,Avishek Nandiet al. PLoS ONE, 2012, 7 (1), pp.e30233. ⟨10.1371/journal.pone.0030233⟩ Article dans une revue cea-02530537v1
Stabilization of HIV-1 Envelope in the CD4-bound Conformation through Specific Cross-linking of a CD4 Mimetic Grégoire Martin,Brian Burke,Robert Thai,Antu Dey,Olivier Combeset al. Journal of Biological Chemistry, 2011, 286 (24), pp.21706-21716 Article dans une revue cea-01989703v1
Quaternary structures of HIV Env immunogen exhibit conformational vicissitudes and interface diminution elicited by ligand binding C. Moscoso,Y. Sun,S. Poon,L. Xing,E. Kanet al. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (15), pp.6091-6096. ⟨10.1073/pnas.1016113108⟩ Article dans une revue cea-02530515v1
Structure-Based Identification and Neutralization Mechanism of Tyrosine Sulfate Mimetics That Inhibit HIV-1 Entry Priyamvada Acharya,Cajetan Dogo-Isonagie,Judith Lalonde,Son Lam,George Leslieet al. ACS Chemical Biology, 2011, 6 (10), pp.1069-1077. ⟨10.1021/cb200068b⟩ Article dans une revue cea-02530519v1
Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells Maylis Dagouassat,Nadine Suffee,Hanna Hlawaty,Oualid Haddad,Faten Charniet al. International Journal of Cancer, 2010, 126 (5), pp.1095-1108. ⟨10.1002/ijc.24800⟩ Article dans une revue cea-02529147v1
P19-23. Putative prefusion mechanism of HIV-1 Env revealed by ligand-induced quaternary alterations in o-gp140 trimers Cg Moscoso,E Kan,S Poon,Y. Sun,Loïc M Martinet al. Retrovirology, 2009, 6 (Suppl 3), pp.P343. ⟨10.1186/1742-4690-6-S3-P343⟩ Article dans une revue hal-02542974v1
Structural Studies of the Complex Between Akt-in and the Akt2-PH Domain Suggest that the Peptide Acts as an Allosteric Inhibitor of the Akt Kinase Virginie Ropars,Philippe Barthe,Chi-Shien Wang,Wenlung Chen,Der-Lii Tzouet al. The Open Spectroscopy Journal, 2009, 3 (1), pp.65-76. ⟨10.2174/1874383800903010065⟩ Article dans une revue hal-02543033v1
A global benchmark study using affinity-based biosensors Rebecca L. Rich,Giuseppe A. Papalia,Peter J. Flynn,Jamie Furneisen,John Quinnet al. Analytical Biochemistry, 2009, 386 (2), pp.194-216. ⟨10.1016/j.ab.2008.11.021⟩ Article dans une revue hal-01527917v1
Resistance to the CD4 mimetic mini protein M48-U1 induces changes in a highly conserved region on the HIV-1 gp120 envelope protein K Grupping,L. Heyndrickx,J. Michiels,G. Martin,Loïc M Martinet al. Retrovirology, 2009, 6 (S3-P12-11), ⟨10.1186/1742-4690-6-S3-P177⟩ Article dans une revue hal-02542981v1
Syndecan-1 and syndecan-4 are involved in RANTES/CCL5-induced migration and invasion of human hepatoma cells Faten Charni,Véronique Friand,Oualid Haddad,Hanna Hlawaty,Loïc M Martinet al. Biochimica et Biophysica Acta (BBA) - General Subjects, 2009, 1790 (10), pp.1314-1326. ⟨10.1016/j.bbagen.2009.07.015⟩ Article dans une revue cea-02529135v1
Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein François Stricher,Chih-Chin Huang,Anne Descours,Sophie Duquesnoy,Olivier Combeset al. Journal of Molecular Biology, 2008, 382 (2), pp.510-524. ⟨10.1016/j.jmb.2008.06.069⟩ Article dans une revue hal-02528576v1
A simple one-step method for the preparation of HIV-1 envelope glycoprotein immunogens based on a CD4 mimic peptide Grégoire Martin,Yide Sun,Bernadette Heyd,Olivier Combes,Jeffrey Ulmeret al. Virology, 2008, 381 (2), pp.241-250. ⟨10.1016/j.virol.2008.08.039⟩ Article dans une revue hal-02528592v1
Glycosaminoglycans and their synthetic mimetics inhibit RANTES-induced migration and invasion of human hepatoma cells. Angela Sutton,Veronique Friand,Dulce Papy-Garcia,Maylis Dagouassat,Loïc M Martinet al. Molecular Cancer Therapeutics, 2007, 6 (11), pp.2948-58. ⟨10.1158/1535-7163.MCT-07-0114⟩ Article dans une revue hal-00195453v1
A high-throughput fluorescence polarization assay specific to the CD4 binding site of HIV-1 glycoproteins based on a fluorescein-labelled CD4 mimic François Stricher,Loïc M Martin,Philippe Barthe,Vivian Pogenberg,Alain Mechulamet al. Biochemical Journal, 2005, 390 (1), pp.29-39. ⟨10.1042/BJ20041953⟩ Article dans une revue hal-02528566v1
Scorpion-Toxin Mimics of CD4 in Complex with Human Immunodeficiency Virus gp120 Chih-Chin Huang,François Stricher,Loïc M Martin,Julie Decker,Shahzad Majeedet al. Structure, 2005, 13 (5), pp.755-768. ⟨10.1016/j.str.2005.03.006⟩ Article dans une revue hal-02528561v1
Crystal Structure of the Broadly Cross-Reactive HIV-1-Neutralizing Fab X5 and Fine Mapping of Its Epitope † , ‡ Ramalakshmi Darbha,Sanjay Phogat,Aran Labrijn,Yuuei Shu,Yijun Guet al. Biochemistry, 2004, 43 (6), pp.1410-1417. ⟨10.1021/bi035323x⟩ Article dans une revue istex hal-02543015v1
Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes Loïc M Martin,François Stricher,Dorothée Missé,Francesca Sironi,Martine Pugnièreet al. Nature Biotechnology, 2003, 21 (1), pp.71-76. ⟨10.1038/nbt768⟩ Article dans une revue hal-02528557v1
Synthesis and characterization of biologically functional biotinylated RANTES Claudio Vita,Eugenia Drakopoulou,Loyda Ylisastigui,Youssef Bakri,Jean Vizzavonaet al. Journal of Immunological Methods, 2002, 266 (1-2), pp.53-65. ⟨10.1016/s0022-1759(02)00096-0⟩ Article dans une revue istex hal-02528550v1
Heparin-aggregated RANTES can be crystallised. Enrico A Stura,Loïc M Martin,Hugues Lortat-Jacob,Romain R Vivès,Claudio Vita Acta crystallographica Section D : Structural biology [1993-..], 2002, 58 (Pt 10 Pt 1), pp.1670-3 Article dans une revue hal-01061424v1
Role of Disulfide Bonds in Folding and Activity of Leiurotoxin I: Just Two Disulfides Suffice Qi Zhu,Songping Liang,Loïc M Martin,Sylvaine Gasparini,André Ménezet al. Biochemistry, 2002, 41 (38), pp.11488-11494. ⟨10.1021/bi026136m⟩ Article dans une revue istex hal-02528546v1
Structural and Functional Analysis of the RANTES-Glycosaminoglycans Interactions Loïc M Martin,Cédric Blanpain,Pascale Garnier,Valérie Wittamer,Marc Parmentieret al. Biochemistry, 2001, 40 (21), pp.6303-6318. ⟨10.1021/bi002670n⟩ Article dans une revue istex hal-02528544v1
Solid-phase synthesis of peptides containing the spin-labeled 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid (TOAC) Loïc M Martin,C. Vita,A. Ivancich,F. Formaggio,C. Toniolo Journal of Peptide Research, 2001, 58 (5), pp.424-432. ⟨10.1034/j.1399-3011.2001.00940.x⟩ Article dans une revue istex hal-02543003v1
Engineering Novel Bioactive Mini-Proteins on Natural Scaffolds Loïc M Martin,Philipe Barthe,Olivier Combes,Christian Roumestand,Claudio Vita Tetrahedron, 2000, 56 (48), pp.9451-9460. ⟨10.1016/S0040-4020(00)00829-2⟩ Article dans une revue istex hal-02528540v1
Engineering Novel Bioactive Mini-Proteins from Small Size Natural and De Novo Designed Scaffolds Loïc M Martin,Claudio Vita Current Protein and Peptide Science, 2000, 1 (4), pp.403-430. ⟨10.2174/1389203003381306⟩ Article dans une revue hal-02543052v1
Metallopeptidase Inhibitors of Tetanus Toxin: A Combinatorial Approach Loïc M Martin,Fabrice Cornille,Serge Turcaud,Hervé Meudal,Bernard P. Roqueset al. Journal of Medicinal Chemistry, 1999, 42 (3), pp.515-525. ⟨10.1021/jm981066w⟩ Article dans une revue istex hal-02528535v1
β-Amino-thiols Inhibit the Zinc Metallopeptidase Activity of Tetanus Toxin Light Chain Loïc M Martin,Fabrice Cornille,Pascale Coric,Bernard P. Roques,Marie-Claude Fournie-Zaluski Journal of Medicinal Chemistry, 1998, 41 (18), pp.3450-3460. ⟨10.1021/jm981015z⟩ Article dans une revue istex hal-02461413v1
Cooperative Exosite-dependent Cleavage of Synaptobrevin by Tetanus Toxin Light Chain Fabrice Cornille,Loïc M Martin,Christine Lenoir,Didier Cussac,Bernard P. Roqueset al. Journal of Biological Chemistry, 1997, 272 (6), pp.3459-3464. ⟨10.1074/jbc.272.6.3459⟩ Article dans une revue hal-02528515v1
2,4-Dinitrophenyl 4-Methoxybenzyl Disulfide: A New Efficient Reagent for the Electrophilic Sulfenylation of β-Amino Ester Enolates Laurent Bischoff,Christelle David,Loïc M Martin,Hervé Meudal,Bernard-Pierre Roqueset al. Journal of Organic Chemistry, 1997, 62 (14), pp.4848-4850. ⟨10.1021/jo9623853⟩ Article dans une revue istex hal-02122111v1
Allosteric-type control of synaptobrevin cleavage by tetanus toxin light chain Fabrice Cornille,Loïc M Martin,Christine Lenoir,Didier Cussac,Bernard P. Roqueset al. Letters in Peptide Science, 1997, 4 (4-6), pp.207-212. ⟨10.1007/BF02442877⟩ Article dans une revue istex hal-02528513v1
A Sensitive and Rapid Fluorescence-Based Assay for Determination of Tetanus Toxin Peptidase Activity Jean-Marc Soleilhac,Fabrice Cornille,Loïc M Martin,Christine Lenoir,Marie-Claude Fournié-Zaluskiet al. Analytical Biochemistry, 1996, 241 (1), pp.120-127. ⟨10.1006/abio.1996.0385⟩ Article dans une revue istex hal-02528509v1

Chapitre d'ouvrage (1)

Design of Miniproteins by the Transfer of Active Sites Onto Small-Size Scaffolds François Stricher,Loïc M Martin,Claudio Vita Protein Design, 340, Humana Press, pp.113-150, 2006, Part of the Methods in Molecular Biology book series (MIMB, volume 340), ⟨10.1385/1-59745-116-9:113⟩ Chapitre d'ouvrage hal-02528572v1

Brevet (1)

IN-CELL CONTINUOUS TARGET-GENE EVOLUTION, SCREENING AND SELECTION Oscar Henrique Pereira Ramos,Loïc M Martin France, Patent n° : WO2021233975A1. 2020 Brevet hal-04459124v1