Gervaise Loirand

Publications

Article dans une revue (47)

Identification of rare missense variants reducing cathepsin O secretion in families with intracranial aneurysm Milène Fréneau,Raphaël Blanchet,Maxence Bodet,Sandro Benichi,Mary-Adel Mradet al. Cardiovascular Research, 2026, 2026, pp.cvaf279 Article dans une revue hal-05477295v1
Platelets in Intracranial Aneurysm: The Missing Actors in the Drama? Clémence Maupu,Garance Ennesser,Celine Baron-Menguy,Maxence Bodet,Gervaise Loirandet al. Arteriosclerosis, Thrombosis, and Vascular Biology, 2026, 46 (3), ⟨10.1161/atvbaha.125.323171⟩ Article dans une revue hal-05549193v1
ARHGEF18 is a flow-responsive exchange factor controlling endothelial tight junctions and vascular leakage Surya Prakash Rao Batta,Marc Rio,Corentin Lebot,Céline Baron-Menguy,Maxence Bodetet al. Cell Reports, 2025, 44 (3), pp.115288. ⟨10.1016/j.celrep.2025.115288⟩ Article dans une revue hal-05241273v1
Impact de l'activation de Rac1 dans la dégranulation des éosinophiles au cours de l'asthme sévère H Bergereau,D Hassoun,Q Marquant,M Rousselle,A Magnanet al. Revue des Maladies Respiratoires, 2025, ⟨10.1016/j.rmr.2025.02.006⟩ Article dans une revue hal-05034532v1
A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer Florian Dilasser,Lindsay Rose,Agnès Quemener,Yann Ferrandez,Dorian Hassounet al. Cell Reports Medicine, 2025, 6 (7), pp.102233. ⟨10.1016/j.xcrm.2025.102233⟩ Article dans une revue hal-05239632v1
Allergic Sensitization Driving Immune Phenotyping and Disease Severity in a Mouse Model of Asthma Eléonore Dijoux,Martin Klein,Barbara Misme-Aucouturier,Marie-Aude Chemina,Marion de Carvalhoet al. Allergy, Asthma & Immunology Research, 2023, 15 (2), pp.e9. ⟨10.4168/aair.2023.15.e9⟩ Article dans une revue hal-03953921v1
Bifurcation geometry remodelling of vessels in de novo and growing intracranial aneurysms: a multicenter study Julien Boucherit,Basile Kerleroux,Gregoire Boulouis,Guillaume Tessier,Christine Rodriguezet al. Journal of Neurointerventional Surgery, 2023, 15 (6), pp.566-571. ⟨10.1136/neurintsurg-2021-018487⟩ Article dans une revue hal-04504270v1
Why Are Women Predisposed to Intracranial Aneurysm? Milène Fréneau,Céline Baron-Menguy,Anne-Clémence Vion,Gervaise Loirand Frontiers in Cardiovascular Medicine, 2022, 9, ⟨10.3389/fcvm.2022.815668⟩ Article dans une revue hal-03795402v1
Sildenafil-Induced Revascularization of Rat Hindlimb Involves Arteriogenesis through PI3K/AKT and eNOS Activation Celine Baron-Menguy,Arnaud Bocquet,Alexis Richard,Anne-Laure Guihot,Bertrand Toutainet al. International Journal of Molecular Sciences, 2022, 23, ⟨10.3390/ijms23105542⟩ Article dans une revue hal-03814145v1
ARHGEF26: a new player in vascular endothelial growth factor receptor 2 trafficking Anne-Clémence Vion,Gervaise Loirand Cardiovascular Research, 2022, ⟨10.1093/cvr/cvac149⟩ Article dans une revue hal-03795397v1
Bronchial smooth muscle cell in asthma: where does it fit? Dorian Hassoun,Lindsay Rose,François-Xavier Blanc,Antoine O. Magnan,Gervaise Loirandet al. BMJ open respiratory research, 2022, 9 (1), pp.e001351. ⟨10.1136/bmjresp-2022-001351⟩ Article dans une revue hal-03837374v1
Smooth muscle Rac1 contributes to pulmonary hypertension Florian Dilasser,Marc Rio,Lindsay Rose,Angela Tesse,Christophe Guignabertet al. British Journal of Pharmacology, 2022, Online ahead of print. ⟨10.1111/bph.15805⟩ Article dans une revue inserm-03558860v1
Location of intracranial aneurysms is the main factor associated with rupture in the ICAN population Olivia Rousseau,Matilde Karakachoff,Alban Gaignard,Lise Bellanger,Philippe Bijlengaet al. Journal of Neurology, Neurosurgery and Psychiatry, 2021, 92 (2), jnnp-2020-324371. ⟨10.1136/jnnp-2020-324371⟩ Article dans une revue hal-03033899v1
Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling Florian Dilasser,Lindsay Rose,Dorian Hassoun,Martin Klein,Morgane Rousselleet al. Thorax, In press, ⟨10.1136/thoraxjnl-2020-216271⟩ Article dans une revue hal-03142499v2
Structural Design and Analysis of the RHOA-ARHGEF1 Binding Mode: Challenges and Applications for Protein-Protein Interface Prediction Ennys Gheyouche,Matthias Bagueneau,Gervaise Loirand,Bernard Offmann,Stéphane Téletchéa Frontiers in Molecular Biosciences, 2021, 8, ⟨10.3389/fmolb.2021.643728⟩ Article dans une revue hal-04064225v1
Prediction of Unruptured Intracranial Aneurysm Evolution: The UCAN Project Vincent L'Allinec,Stéphanie Chatel,Matilde Karakachoff,Emmanuelle Bourcereau,Zeineb Es-Salah-Lamoureuxet al. Neurosurgery, 2020, ⟨10.1093/neuros/nyaa093⟩ Article dans une revue hal-02889889v1
Characterization of 3D Bifurcations in Micro-scan and MRA-TOF Images of Cerebral Vasculature for Prediction of Intra-Cranial Aneurysms Anass Nouri,Florent Autrusseau,Romain Bourcier,Alban Gaignard,Vincent L'Allinecet al. Computerized Medical Imaging and Graphics, 2020, 84C, ⟨10.1016/j.compmedimag.2020.101751⟩ Article dans une revue hal-02888926v1
RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome Nadjet Belbachir,Vincent Portero,Zeina Al Sayed,Jean-Baptiste Gourraud,Florian Dilasseret al. European Heart Journal, 2019, ⟨10.1093/eurheartj/ehz308⟩ Article dans une revue inserm-02158572v1
Nouveaux acteurs dans la physiopathologie de l’asthme Martin Klein,Eléonore Dijoux,Florian Dilasser,Dorian Hassoun,Antoine Mouiet al. La Presse Médicale, 2019, 48 (3), pp.255-261. ⟨10.1016/j.lpm.2019.01.004⟩ Article dans une revue hal-02101364v1
Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats Joseph Iharinjaka Randriamboavonjy,Sandrine Heurtebise,Pierre Pacaud,Gervaise Loirand,Angela Tesse Oxidative Medicine and Cellular Longevity, 2019, 2019, pp.2567198. ⟨10.1155/2019/2567198⟩ Article dans une revue hal-02152327v1
Rare Coding Variants in ANGPTL6 Are Associated with Familial Forms of Intracranial Aneurysm Romain Bourcier,Solena Le Scouarnec,Stéphanie Bonnaud,Matilde Karakachoff,Emmanuelle Bourcereauet al. American Journal of Human Genetics, 2018, 102 (1), pp.133 - 141. ⟨10.1016/j.ajhg.2017.12.006⟩ Article dans une revue hal-01808225v1
Moringa oleifera Seeds Attenuate Vascular Oxidative and Nitrosative Stresses in Spontaneously Hypertensive Rats Joseph Iharinjaka Randriamboavonjy,Marc Rio,Pierre Pacaud,Gervaise Loirand,Angela Tesse Oxidative Medicine and Cellular Longevity, 2017, 2017, pp.4129459. ⟨10.1155/2017/4129459⟩ Article dans une revue hal-01832936v1
Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness Gwennan André-Grégoire,Florian Dilasser,Julie Chesné,Faouzi Braza,Antoine Magnanet al. Journal of Allergy and Clinical Immunology, 2017, Equipe III, ⟨10.1016/j.jaci.2017.09.049⟩ Article dans une revue hal-01828862v1
Understanding the Pathophysiology of Intracranial Aneurysm: The ICAN Project Romain Bourcier,Stéphanie Chatel,Emmanuelle Bourcereau,Solène Jouan,Hervé Le Marecet al. Neurosurgery, 2017, 80 (4), pp.621-626. ⟨10.1093/neuros/nyw135⟩ Article dans une revue hal-01768333v1
Leukocyte RhoA exchange factor Arhgef1 mediates vascular inflammation and atherosclerosis Maria Luigia Carbone,Gilliane Chadeuf,Sandrine Heurtebise-Chrétien,Xavier Prieur,Thibault Quillardet al. Journal of Clinical Investigation, 2017, Equipe III Equipe IV, 127 (12), pp.4516--4526. ⟨10.1172/JCI92702⟩ Article dans une revue hal-01832942v1
Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1 Jonatan Barrera-Chimal,Gwennan André-Grégoire,Aurelie Nguyen Dinh Cat,Sebastian M. Lechner,Jérôme Cauet al. Journal of the American Society of Nephrology, 2017, 28 (4), pp.1216-1226. ⟨10.1681/ASN.2016040477⟩ Article dans une revue hal-01832953v1
In Vitro and In Vivo Approaches to Assess Rho Kinase Activity Vincent Sauzeau,Gervaise Loirand Methods in Molecular Biology, 2017, Hypertension Methods and Protocols, 1527, pp.213--218. ⟨10.1007/978-1-4939-6625-7_17⟩ Article dans une revue hal-01832946v1
Cardiac protective effects of Moringa oleifera seeds in spontaneous hypertensive rats Joseph Randriamboavonjy,Gervaise Loirand,Nathalie Vaillant,Benjamin Lauzier,Séverine Derbréet al. American Journal of Hypertension, 2016, 29 (7), pp.873-881. ⟨10.1093/ajh/hpw001⟩ Article dans une revue hal-01389199v1
Rho Kinases in Health and Disease: From Basic Science to Translational Research Gervaise Loirand Pharmacological Reviews, 2015, 67 (4), pp.1074--1095. ⟨10.1124/pr.115.010595⟩ Article dans une revue hal-01830591v1
SUN2 accumulation contributes to vascular smooth muscle cell alterations induced by matrix rigidity Néjma Bélaadi,Gilliane Chadeuf,Luan Nguyen,Marc Rio,G. Louarnet al. FASEB Journal, 2015, 29 Article dans une revue hal-01726012v1
Prime role of IL-17A in neutrophilia and airway smooth muscle contraction in a house dust mite-induced allergic asthma model Julie Chesné,Faouzi Braza,Gilliane Chadeuf,Guillaume Mahay,Marie-Aude Cheminantet al. Journal of Allergy and Clinical Immunology, 2015, 135 (6), pp.1643-1643.e3. ⟨10.1016/j.jaci.2014.12.1872⟩ Article dans une revue hal-01830585v1
Angiotensin II Activates the RhoA Exchange Factor Arhgef1 in Humans Maria Luigia Carbone,Jérémy Brégeon,Nabila Devos,Gilliane Chadeuf,Anne Blanchardet al. Hypertension, 2015, Equipe 2, 65 (6), pp.1273--1278. ⟨10.1161/HYPERTENSIONAHA.114.05065⟩ Article dans une revue hal-01830595v1
Increased β2-adrenergic vasorelaxation at the early phase of endotoxemic shock in rats David Roul,Bertrand Rozec,Gwenann André,Nolwenn Merlet,T. Tran Quanget al. Vascular Pharmacology, 2015, Equipe 1 Equipe 2, 72, pp.181--189. ⟨10.1016/j.vph.2015.04.007⟩ Article dans une revue istex hal-01830593v1
PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension Jean-Mathieu Berger,Nathalie Vaillant,Cedric Le May,Carolina Calderon,Jeremy Brégeonet al. Atherosclerosis, 2015, Equipe 2 Equipe 5, 239 (1), pp.252--259. ⟨10.1016/j.atherosclerosis.2015.01.012⟩ Article dans une revue istex hal-01830594v1
Advanced glycation inhibition and protection against endothelial dysfunction induced by coumarins and procyanidins from Mammea neurophylla. Bach Tai Dang,Charlotte Gény,Patricia Blanchard,Caroline Rouger,Pierre Tonnerreet al. Fitoterapia, 2014, 96, pp.65-75. ⟨10.1016/j.fitote.2014.04.005⟩ Article dans une revue istex hal-01059141v1
Smooth Muscle Specific Rac1 Deficiency Induces Hypertension by Preventing p116 RIP 3 ‐Dependent RhoA Inhibition Gwennan André,Juan Sandoval,Kevin Retailleau,Laurent Loufrani,Gilles Toumaniantzet al. Journal of the American Heart Association, 2014, 3 (3), ⟨10.1161/JAHA.114.000852⟩ Article dans une revue hal-02347180v1
Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response Natalia F. Smirnova,Stephanie Gayral,Christophe Pedros,Gervaise Loirand,Nathalie Vaillantet al. Journal of Experimental Medicine, 2014, 211 (9), pp.1779-1792. ⟨10.1084/jem.20131276⟩ Article dans une revue hal-02519407v1
Shear Stress Regulates Endothelial Microparticle Release Anne-Clémence Vion,Bhama Ramkhelawon,Xavier Loyer,Gilles Chironi,Cecile Devueet al. Circulation Research, 2013, 112 (10), pp.1323-1333. ⟨10.1161/CIRCRESAHA.112.300818⟩ Article dans une revue hal-03367508v1
n-3 PUFA prevent metabolic disturbances associated with obesity and improve endothelial function in golden Syrian hamsters fed with a high-fat diet Fatima Kasbi Chadli,Agnès André,Xavier Prieur,Gervaise Loirand,Anne Meynieret al. British Journal of Nutrition, 2012, 107 (9), pp.1305 - 1315. ⟨10.1017/S0007114511004387⟩ Article dans une revue hal-02644896v1
WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice. Sonia Bergaya,Sébastien Faure,Véronique Baudrie,Marc Rio,Brigitte Escoubetet al. Hypertension, 2011, 58 (3), pp.439-45. ⟨10.1161/HYPERTENSIONAHA.111.172429⟩ Article dans une revue hal-00945534v1
Regulation of Rho signaling pathways in interleukin-2-stimulated human T-lymphocytes. Rym Mzali,Laetitia Seguin,Caroline Liot,Anick Auger,Pierre Pacaudet al. FASEB Journal, 2005, 19 (13), pp.1911-3. ⟨10.1096/fj.05-4030fje⟩ Article dans une revue hal-00192794v1
Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells. Malvyne Rolli-Derkinderen,Vincent Sauzeau,Laurent Boyer,Emmanuel Lemichez,Céline Baronet al. Circulation Research, 2005, 96, pp.1152-60. ⟨10.1161/01.RES.0000170084.88780.ea⟩ Article dans une revue inserm-00000098v1
Structure–Activity Relationships of Human Urotensin II and Related Analogues on Rat Aortic Ring Contraction Patricia Labarrère,David Chatenet,Jérôme Leprince,Céline Marionneau,Gervaise Loirandet al. Journal of Enzyme Inhibition and Medicinal Chemistry, 2003, 18 (2), pp.77-88. ⟨10.1080/1475636031000093507⟩ Article dans une revue hal-01962785v1
RhoA expression is controlled by nitric oxide through cGMP-dependent protein kinase activation Vincent Sauzeau,M. Rolli-Derkinderen,Céline Marionneau,Gervaise Loirand,Pierre Pacaud Journal of Biological Chemistry, 2003, 278 (11), pp.9472-80. ⟨10.1074/jbc.M212776200⟩ Article dans une revue hal-02363792v1
Dependence of P2-nucleotide receptor agonist-mediated endothelium-independent relaxation on ectonucleotidase activity and A 2A -receptors in rat portal vein Christelle Guibert,Gervaise Loirand,Paul Vigne,Jean-Pierre Savineau,Pierre Pacaud British Journal of Pharmacology, 1998, 123 (8), pp.1732-1740. ⟨10.1038/sj.bjp.0701773⟩ Article dans une revue hal-02439074v1
Autoanti-phosphatidylinositide antibodies specifically inhibit noradrenaline effects on Ca2+ and Cl- channels in rat portal vein myocytes. Gervaise Loirand,Sylvie Faiderbe,Anne Baron,Michel Geffard,Jean Mironneau Journal of Biological Chemistry, 1992, 267 (7), pp.4312-4316 Article dans une revue hal-02277572v1
Ca2+ channel activation and membrane depolarization mediated by Cl− channels in response to noradrenaline in vascular myocytes Pierre Pacaud,Gervaise Loirand,Anne Baron,Chantal Mironneau,Jean Mironneau British Journal of Pharmacology, 1991, 104 (4), pp.1000-1006. ⟨10.1111/j.1476-5381.1991.tb12540.x⟩ Article dans une revue hal-02277610v1

Communication dans un congrès (1)

3D bifurcations characterization for intra-cranial aneurysms prediction Anass Nouri,Florent Autrusseau,Romain Bourcier,Alban Gaignard,Vincent L'Allinecet al. SPIE Medical Imaging, Feb 2019, San Diego, CA, United States. ⟨10.1117/12.2504626⟩ Communication dans un congrès hal-01896717v1

Pré-publication, Document de travail (4)

NET1/ARHGEF8 is a mechanosensitive Guanine Exchange Factor controlling vascular smooth muscle cells' contractility Mary-Adel Mrad,Surya Prakash Rao Batta,Virginie Vignard,Marc Rio,Gilliane Chadeufet al. 2025 Pré-publication, Document de travail hal-05390226v1
ANGPTL6 variant induces cerebral vascular dysfunction and predisposes to intracranial aneurysm in mice Céline Baron-Menguy,Milène Freneau,Mary-Adel Mrad,Corentin Lebot,Marc Rioet al. 2025 Pré-publication, Document de travail hal-05343639v1
Rare coding variants in CTSO , a potential new actor of arterial remodeling, are associated to familial intracranial aneurysm Milène Fréneau,Raphaël Blanchet,Sandro Benichi,Mary-Adel Mrad,Surya Prakash Rao Battaet al. 2023 Pré-publication, Document de travail hal-03999154v1
ARHGEF18 participates in Endothelial Cell Mechano-sensitivity in Response to Flow Surya Prakash Rao Batta,Marc Rio,Corentin Lebot,Céline Baron-Menguy,Robin Le Ruzet al. 2022 Pré-publication, Document de travail hal-03795411v1