Luca Dirheimer PhD Student.CRAN laboratory - Lorraine Institute of Oncology.Functionalization of near infrared Quantum Dots and fluorescence quantification on cell models: application to fluorescence-guided surgery of head and neck cancers

Identifiants chercheurs

IdHAL :

luca-dirheimer

ORCID :

0000-0002-2607-4652

Présentation

PhD student at CRAN laboratory and Lorraine Institute of Oncology, I am working with Quantum Dots (QDs) to target 3D Head and Neck cancer spheroids as a part of a project willing to improve Fluorescence Guided Surgery. My project focuses on the development of 3D spheroid models and the characterization of QDs potential using flow cytometry and fluorescence microscopy analysis.

Before that, I graduated with a Master's degree in Life Sciences - Biotechnology - Cellular engineering at the Faculty of Science and Technology of Vandoeuvre-Lès-Nancy, France.

Publications

Article dans une revue (5)

Fluorescence Imaging-Assessed Surgical Margin Detection in Head and Neck Oncology by Passive and Active Targeting L. Dirheimer,S. Cortese,G. Dolivet,Jean-Louis Merlin,F. Marchalet al. Molecular Diagnosis and Therapy, 2025, 29 (4), pp.465-481. ⟨10.1007/s40291-025-00781-x⟩ Article dans une revue hal-05400263v1
Targeting of 3D oral cancer spheroids by αVβ6 integrin using near-infrared peptide-conjugated IRDye 680 Luca Dirheimer,Thomas Pons,Aurélie François,Laureline Lamy,Sophie Corteseet al. Cancer Cell International, 2024, 24 (1), pp.228. ⟨10.1186/s12935-024-03417-y⟩ Article dans une revue hal-04636463v1
Peptide-mediated targeting of Quantum Dots in a 3D model of head and neck cancer Luca Dirheimer,Thomas Pons,Aurélie François,Laureline Lamy,Frédéric Marchalet al. Photodiagnosis and Photodynamic Therapy, 2024, 49 (9), pp.104337. ⟨10.1016/j.pdpdt.2024.104337⟩ Article dans une revue hal-04838927v1
A macrophages-enriched head and neck tumor spheroid model to study Foslip® behavior in tumor microenvironment Aurélie François,Luca Dirheimer,Alicia Chateau,Henri-Pierre Lassalle,Ilya Yakavetset al. International Journal of Nanomedicine, 2023, 18, pp.6545-6562. ⟨10.2147/IJN.S427350⟩ Article dans une revue hal-04291290v1
Quantum dots mediated imaging and phototherapy in cancer spheroid models : state of the art and perspectives Luca Dirheimer,Thomas Pons,Frédéric Marchal,Lina Bezdetnaya Pharmaceutics, 2022, 14 (10), pp.2136. ⟨10.3390/pharmaceutics14102136⟩ Article dans une revue hal-03833131v1

Thèse (1)

Ciblage de modèles cellulaires 3D par des agents de contrastes fluoresçant dans le proche infrarouge : application à la chirurgie guidée par la fluorescence des cancers de la tête et du cou Luca Dirheimer Cancer. Université de Lorraine, 2024. Français. ⟨NNT : 2024LORR0159⟩ Thèse tel-04947303v1