Luca Grumolato

Publications

Article dans une revue (42)

Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells Lisa Brunet,David Alexandre,Jiyoung Lee,Maria del Mar Blanquer-Rosselló,David Bracquemondet al. Nature Communications, 2025, 16, pp.7853. ⟨10.1038/s41467-025-61788-w⟩ Article dans une revue hal-05292896v1
Central SELENOT deficiency impairs gonadotrope axis function, sexual behavior and fertility in male and female mice Ben Yamine Mallouki,Loubna Boukhzar,Ludovic Dumont,Azénor Abgrall,Marjorie Graset al. JCI Insight, 2025, 10 (24), pp.e189775. ⟨10.1172/jci.insight.189775⟩ Article dans une revue hal-05397502v1
Mechanisms of Acquired Resistance and Tolerance to EGFR Targeted Therapy in Non-Small Cell Lung Cancer Houssein Chhouri,David Alexandre,Luca Grumolato Cancers, 2023, 15 (2), pp.504. ⟨10.3390/cancers15020504⟩ Article dans une revue hal-05043716v1
MET exon 14 skipping mutation is a hepatocyte growth factor (HGF)-dependent oncogenic driver in vitro and in humanized HGF knock-in mice. Marie Fernandes,B. Hoggard,Philippe Jamme,Sonia Paget,Marie-Jose Truonget al. Molecular Oncology, 2023, Molecular Oncology, 17 (11), p. 2257-2274. ⟨10.1002/1878-0261.13397⟩ Article dans une revue hal-04405493v1
High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer Anita Rogic,Ila Pant,Luca Grumolato,Ruben Fernandez-Rodriguez,Andrew Edwardset al. Nature Communications, 2021, 12 (1), pp.6889. ⟨10.1038/s41467-021-27108-8⟩ Article dans une revue hal-05043720v1
ROR2 has a protective role in melanoma by inhibiting Akt activity, cell-cycle progression, and proliferation María Victoria Castro,Gastón Alexis Barbero,María Belén Villanueva,Luca Grumolato,Jérémie Nsengimanaet al. Journal of Biomedical Science, 2021, 28 (1), pp.76. ⟨10.1186/s12929-021-00776-w⟩ Article dans une revue hal-05139244v1
XPO1E571K Mutation Modifies Exportin 1 Localisation and Interactome in B-cell Lymphoma Hadjer Miloudi,Elodie Bohers,François Guillonneau,Antoine Taly,Vincent Cabaud Gibouinet al. Cancers, 2020, 12 (10), pp.2829. ⟨10.3390/cancers12102829⟩ Article dans une revue hal-02957363v1
Tolerant/Persister Cancer Cells and the Path to Resistance to Targeted Therapy Mirna Swayden,Houssein Chhouri,Youssef Anouar,Luca Grumolato Cells, 2020, 9 (12), pp.2601. ⟨10.3390/cells9122601⟩ Article dans une revue hal-05043732v1
CRISPR/Cas9 editing of the genome for cancer modeling Alexis Guernet,Luca Grumolato Methods, 2017, 121-122, pp.130-137. ⟨10.1016/j.ymeth.2017.03.007⟩ Article dans une revue istex hal-02017519v1
Selenoprotein T is a novel OST subunit that regulates UPR signaling and hormone secretion Abdallah Hamieh,Dorthe Cartier,Houssni Abid,André Calas,Carole Burelet al. EMBO Reports, 2017, 18 (11), pp.1935 - 1946. ⟨10.15252/embr.201643504⟩ Article dans une revue hal-01777667v1
CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations Alexis Guernet,Sathish kumar Mungamuri,Dorthe Cartier,Ravi Sachidanandam,Anitha Jayaprakashet al. Molecular Cell, 2016, 63 (3), pp.526-538. ⟨10.1016/j.molcel.2016.06.017⟩ Article dans une revue hal-02376161v1
Modeling intratumor heterogeneity through CRISPR-barcodes Alexis Guernet,Stuart A. Aaronson,Youssef Anouar,Luca Grumolato Molecular & Cellular Oncology, 2016, 3 (6), pp.e1227894. ⟨10.1080/23723556.2016.1227894⟩ Article dans une revue hal-02017522v1
ROR1 contributes to melanoma cell growth and migration by regulating N‐cadherin expression via the PI3K/Akt pathway Natalia Brenda Fernández,Daniela Lorenzo,María Elisa Picco,Gastón Barbero,Leonardo Sebastián Dergan-Dylonet al. Molecular Carcinogenesis, 2015, 55 (11), pp.1772-1785. ⟨10.1002/mc.22426⟩ Article dans une revue hal-05043739v1
Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Promotes Both Survival and Neuritogenesis in PC12 Cells through Activation of Nuclear Factor κB (NF-κB) Pathway Destiny-Love Manecka,Sardar Faisal Mahmood,Luca Grumolato,Isabelle Lihrmann,Youssef Anouar Journal of Biological Chemistry, 2013, 288 (21), pp.14936-14948. ⟨10.1074/jbc.M112.434597⟩ Article dans une revue hal-02427077v1
β-Catenin-Independent Activation of TCF1/LEF1 in Human Hematopoietic Tumor Cells through Interaction with ATF2 Transcription Factors Luca Grumolato,Guizhong Liu,Tomomi Haremaki,Sathish Kumar Mungamuri,Phyllus Monget al. PLoS Genetics, 2013, 9 (8), pp.e1003603. ⟨10.1371/journal.pgen.1003603⟩ Article dans une revue hal-02017513v1
Wnk kinases are positive regulators of canonical Wnt/β‐catenin signalling Ekatherina Serysheva,Hebist Berhane,Luca Grumolato,Kubilay Demir,Sophie Balmeret al. EMBO Reports, 2013, 14 (8), pp.718-725. ⟨10.1038/embor.2013.88⟩ Article dans une revue hal-05043746v1
Chromatin Modifications Sequentially Enhance ErbB2 Expression in ErbB2-Positive Breast Cancers Sathish Kumar Mungamuri,William Murk,Luca Grumolato,Emily Bernstein,Stuart Aaronsonet al. Cell Reports, 2013, 5 (2), pp.302-313. ⟨10.1016/j.celrep.2013.09.009⟩ Article dans une revue hal-05043743v1
A New Piece to the Unsolved Planar Cell Polarity Puzzle Luca Grumolato,Ursula Weber,Marek Mlodzik Developmental Cell, 2011, 20 (2), pp.146-147. ⟨10.1016/j.devcel.2011.01.013⟩ Article dans une revue hal-05043754v1
Maternal Perinatal Undernutrition has Long-Term Consequences on Morphology, Function and Gene Expression of the Adrenal Medulla in the Adult Male Rat C. Laborie,O. Molendi-Coste,C. Breton,V. Montel,F. Vandenbulckeet al. Journal of Neuroendocrinology, 2011, 23 (8), pp.711-724. ⟨10.1111/j.1365-2826.2011.02159.x⟩ Article dans une revue istex hal-05043752v1
High-Frequency Canonical Wnt Activation in Multiple Sarcoma Subtypes Drives Proliferation through a TCF/β-Catenin Target Gene, CDC25A Sapna Vijayakumar,Guizhong Liu,Ioana Rus,Shen Yao,Yan Chenet al. Cancer Cell, 2011, 19 (5), pp.601-612. ⟨10.1016/j.ccr.2011.03.010⟩ Article dans une revue hal-05043750v1
Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation Jaskirat Singh,Wang Yanfeng,Luca Grumolato,Stuart Aaronson,Marek Mlodzik Genes and Development, 2010, 24 (19), pp.2157-2168. ⟨10.1101/gad.1961010⟩ Article dans une revue hal-05043762v1
Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors Luca Grumolato,Guizhong Liu,Phyllus Mong,Raksha Mudbhary,Romi Biswaset al. Genes and Development, 2010, 24 (22), pp.2517-2530. ⟨10.1101/gad.1957710⟩ Article dans une revue hal-05043757v1
Diverse mechanisms of Wnt activation and effects of pathway inhibition on proliferation of human gastric carcinoma cells S Asciutti,G Akiri,Luca Grumolato,S Vijayakumar,S Aaronson Oncogene, 2010, 30 (8), pp.956-966. ⟨10.1038/onc.2010.475⟩ Article dans une revue hal-05043760v1
Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells Guizhong Liu,Sapna Vijayakumar,Luca Grumolato,Randy Arroyave,Huifang Qiaoet al. Journal of Cell Biology, 2009, 185 (1), pp.67-75. ⟨10.1083/jcb.200810137⟩ Article dans une revue hal-05043763v1
Pharmacological profile of serotonergic receptors in the adrenal gland Catherine Delarue,Vincent Contesse,Herve Lefebvre,Sebastien Lenglet,Luca Grumolatoet al. Endocrine Research, 2009, 24 (3-4), pp.687-694. ⟨10.3109/07435809809032670⟩ Article dans une revue hal-05043799v1
Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca 2+ mobilization and neuroendocrine secretion Luca Grumolato,Hafida Ghzili,Maite Montero-Hadjadje,Stephane Gasman,Jean J. Lesageet al. FASEB Journal, 2008, 22 (6), pp.1756-1768. ⟨10.1096/fj.06-075820⟩ Article dans une revue hal-01962747v1
Identification of Potential Gene Markers and Insights into the Pathophysiology of Pheochromocytoma Malignancy Erwan Thouennon,Abdel G. Elkahloun,Johann Guillemot,Anne-Paule Gimenez-Roqueplo,Jérôme Bertheratet al. Journal of Clinical Endocrinology and Metabolism, 2007, 92 (12), pp.4865 - 4872. ⟨10.1210/jc.2007-1253⟩ Article dans une revue hal-01706427v1
Selenoprotein T is a novel target for PACAP signaling discovered via functionally coupled transcriptome array and gene silencing Youssef Anouar,Hafida Ghzili,Luca Grumolato,Maite Montero-Hadjadje,Stéphane Gasmanet al. Journal of Molecular Neuroscience, 2007, 33 (3) Article dans une revue hal-04847275v1
Pituitary Adenylate Cyclase‐Activating Polypeptide Regulates Neuroendocrine Markers and Transcription Factors in Differentiating Pheochromocytoma Cells Luca Grumolato,D. Alexandre,V. Turquier,D. Ait-Ali,A. Fournieret al. Annals of the New York Academy of Sciences, 2006, 971 (1), pp.467-470. ⟨10.1111/j.1749-6632.2002.tb04510.x⟩ Article dans une revue istex hal-05043786v1
Maternal Perinatal Undernutrition Alters Neuronal and Neuroendocrine Differentiation in the Rat Adrenal Medulla at Weaning Olivier Molendi-Coste,Luca Grumolato,Christine Laborie,Jean Lesage,Eric Maubertet al. Endocrinology, 2006, 147 (6), pp.3050-3059. ⟨10.1210/en.2005-1331⟩ Article dans une revue hal-05043774v1
Proinflammatory Cytokines TNF‐α and IL‐1α Stimulate Neuropeptide Gene Expression in Adrenochromaffin Cells V. Turquier,H. Vaudry,L. Yon,C-M Hsu,D. Ait-Aliet al. Annals of the New York Academy of Sciences, 2006, 971 (1), pp.45-48. ⟨10.1111/j.1749-6632.2002.tb04431.x⟩ Article dans une revue istex hal-05043788v1
Possible implication of the transcriptional regulator Id3 in PACAP-induced pro-survival signaling during PC12 cell differentiation Hafida Ghzili,Luca Grumolato,Erwan Thouënnon,Hubert Vaudry,Youssef Anouar Regulatory Peptides, 2006, 137 (1-2), pp.89-94. ⟨10.1016/j.regpep.2006.06.015⟩ Article dans une revue istex hal-05043771v1
Circulating EM66 is a highly sensitive marker for the diagnosis and follow-up of pheochromocytoma Johann Guillemot,Youssef Anouar,Maïté Montero-Hadjadje,Eric Grouzmann,Luca Grumolatoet al. International Journal of Cancer, 2006, 118 (8), pp.2003 - 2012. ⟨10.1002/ijc.21571⟩ Article dans une revue hal-01706431v1
The Proinflammatory Cytokines Tumor Necrosis Factor-α and Interleukin-1 Stimulate Neuropeptide Gene Transcription and Secretion in Adrenochromaffin Cells via Activation of Extracellularly Regulated Kinase 1/2 and p38 Protein Kinases, and Activator Protein-1 Transcription Factors Djida Aït-Ali,Valérie Turquier,Luca Grumolato,Laurent Yon,Matthieu Jourdainet al. Molecular Endocrinology -Baltimore-, 2004, 18 (7), pp.1721-1739. ⟨10.1210/me.2003-0129⟩ Article dans une revue hal-02334636v1
PACAP and NGF regulate common and distinct traits of the sympathoadrenal lineage: effects on electrical properties, gene markers and transcription factors in differentiating PC12 cells Luca Grumolato,Estelle Louiset,David Alexandre,Djida Aït-Ali,Valérie Turquieret al. European Journal of Neuroscience, 2003, 17 (1), pp.71-82. ⟨10.1046/j.1460-9568.2003.02426.x⟩ Article dans une revue hal-05043781v1
Microarray and Suppression Subtractive Hybridization Analyses of Gene Expression in Pheochromocytoma Cells Reveal Pleiotropic Effects of Pituitary Adenylate Cyclase-Activating Polypeptide on Cell Proliferation, Survival, and Adhesion Luca Grumolato,Abdel G. Elkahloun,Hafida Ghzili,David Alexandre,Cédric Coulouarnet al. Endocrinology, 2003, 144 (6), pp.2368-2379. ⟨10.1210/en.2002-0106⟩ Article dans une revue hal-02334705v1
Identification of the Secretogranin II-Derived Peptide EM66 in Pheochromocytomas as a Potential Marker for Discriminating Benign Versus Malignant Tumors Laurent Yon,Johann Guillemot,Maite Montero-Hadjadje,Luca Grumolato,Jérôme Leprinceet al. Journal of Clinical Endocrinology and Metabolism, 2003, 88 (6), pp.2579-2585. ⟨10.1210/jc.2002-021748⟩ Article dans une revue hal-01706414v1
Novel Splice Variants of Type I Pituitary Adenylate Cyclase-Activating Polypeptide Receptor in Frog Exhibit Altered Adenylate Cyclase Stimulation and Differential Relative Abundance David Alexandre,Hubert Vaudry,Luca Grumolato,Valérie Turquier,Alain Fournieret al. Endocrinology, 2002, 143 (7), pp.2680-2692. ⟨10.1210/endo.143.7.8880⟩ Article dans une revue hal-05043790v1
Pituiray adnylate cylcase-activating polypeptide stimulates secretoneurin release ans secretogranin II gene transcription in bovine adrenochromaffin cells Valérie Turquier,Laurent Yon,Luca Grumolato,D. Alexandre,Alain Fournieret al. Annals of the New York Academy of Sciences, 2002, 971 (1), pp.471-473. ⟨10.1111/j.1749-6632.2002.tb04511.x⟩ Article dans une revue istex hal-02334634v1
Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Secretoneurin Release and Secretogranin II Gene Transcription in Bovine Adrenochromaffin Cells through Multiple Signaling Pathways and Increased Binding of Pre-Existing Activator Protein-1-Like Transcription Factors Valérie Turquier,Laurent Yon,Luca Grumolato,David Alexandre,Alain Fournieret al. Molecular Pharmacology, 2001, 60 (1), pp.42-52. ⟨10.1124/mol.60.1.42⟩ Article dans une revue hal-02334699v1
Molecular characterization of frog chromogranin B reveals conservation of selective sequences encoding potential novel regulatory peptides 1 Djida Aït-Ali,Valérie Turquier,David Alexandre,Luca Grumolato,Sylvie Jégouet al. FEBS Letters, 2001, 511 (1-3), pp.127-132. ⟨10.1016/s0014-5793(01)03296-3⟩ Article dans une revue hal-05043793v1
Pharmacological and Molecular Characterization of 5-Hydroxytryptamine 7 Receptors in the Rat Adrenal Gland Vincent Contesse,Sebastien Lenglet,Luca Grumolato,Youssef Anouar,Isabelle Lihrmannet al. Molecular Pharmacology, 1999, 56 (3), pp.552-561. ⟨10.1124/mol.56.3.552⟩ Article dans une revue hal-02427287v1

Pré-publication, Document de travail (1)

Oncogenic mutations convert MET from a pro-apoptotic tumor suppressor to an oncogenic driver Rémi Tellier,Marie Fernandes,Audrey Vinchent,Sonia Paget,Agathe Laratteet al. 2025 Pré-publication, Document de travail hal-05370296v1

Poster de conférence (3)

Prolonging Lung Cancer Response to EGFR Inhibition by Targeting the Selective Advantage of Resistant Cells Lisa Brunet,David Alexandre,Jiyoung Lee,Maria Del Mar Blanquer-Rosselló,Alexis Guernetet al. Pasteur International Cancer Conference, Nov 2023, Paris, France Poster de conférence hal-05165031v1
Prolonging Lung Cancer Response to EGFR Inhibition by Targeting the Selective Advantage of Resistant Cells Lisa Brunet,Maria Del Mar Blanquer-Rosselló,Alexis Guernet,David Alexandre,Alexis B. Cortotet al. Journée Normande de Recherche Biomédicale, Jun 2022, Rouen, France. 2022 Poster de conférence hal-05164767v1
Co-activation of the invasion and survival contributes to transformation induced by exon 14 splicing of MET receptor in lung cancer Marie Fernandes,Sonia Paget,Zoulika Kherrouche,Anne Chotteau-Lelièvre,Luca Grumolatoet al. 3rd International Symposium Research on Healthy Ageing, Dec 2019, Lille, France Poster de conférence hal-04559723v1

Chapitre d'ouvrage (1)

Aberrant Signaling Pathways in Cancer Luca Grumolato,Stuart A. Aaronson Holland-Frei Cancer Medicine, John Wiley & Sons, Ltd, pp.1-10, 2022, 978-1-119-00082-2 Chapitre d'ouvrage hal-05329616v1

Communication dans un congrès (3)

Résistance du cancer bronchique à la thérapie ciblée : nouveaux modèles d'étude in vitro et in vivo Luca Grumolato Journée de l'axe 1 du Cancéropôle Nord-Ouest, Nov 2022, Paris, France Communication dans un congrès hal-05157033v1
Targeting Tumor Evolution to Prevent Drug Resistance: A New Strategy to Prolong Lung Cancer Response to EGFR Inhibition Luca Grumolato Institute of Biological and Chemical Systems – Functional Molecular Systems, Jan 2020, Karlsruhe, Germany Communication dans un congrès hal-05156995v1
Preventing Acquired Resistance to Therapy by Targeting Tumor Evolution: A New Strategy to Prolong Lung Cancer Response to EGFR Inhibition Luca Grumolato Toulouse Onco Week, Feb 2020, Toulouse, France Communication dans un congrès hal-05156994v1

Proceedings/Recueil des communications (2)

Abstract 3683: MET Exon 14 Skipping Mutations in Lung Cancer: Screening, Functional and Clinical Impact Marie Fernandes,Philippe Jamme,Sonia Paget,Angela Morabito,Frédéric Leprêtreet al. American Association for Cancer Research Annual Meeting 2020, Jun 2020, On line, United States. 80 (16_Supplement), pp.3683, 2020, ⟨10.1158/1538-7445.AM2020-3683⟩ Proceedings/Recueil des communications hal-05329615v1
Caractérisation de nouveaux peptides dérivés des chromogranines comme marqueurs diagnostiques des phéochromocytomes Johann Guillemot,M. Montero-Hadjadje,M. Klein,V. Turquier,L. Grumolatoet al. 21ème Congrès de la Société Française d'Endocrinologie, Sep 2004, Reims, France. Annales d'Endocrinologie = Annals of Endocrinology, 65 (4), pp.399-400, 2004, ⟨10.1016/s0003-4266(04)95922-7⟩ Proceedings/Recueil des communications hal-05369808v1