Lucas TREPS

Publications

Article dans une revue (48)

In vitro models to mimic tumor endothelial cell-mediated immune cell reprogramming in lung adenocarcinoma Morgane Krejbich,Emilie Navarro,Judith Fresquet,Marine Cotinat,Valentin Isenet al. Journal of Experimental and Clinical Cancer Research, 2026, 45 (1), pp.15. ⟨10.1186/s13046-025-03576-4⟩ Article dans une revue hal-05425299v1
MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer-associated fibroblasts Chloé Lefebvre,Philippine Giowachini,Jennifer Derrien,Maxime Naour,Isabelle Correet al. Cell Death and Disease, 2025, 16 (1), pp.603. ⟨10.1038/s41419-025-07920-6⟩ Article dans une revue hal-05217632v1
scRNA-seq data of human lung multicellular tumor spheroid (MCTS) Lucas Treps Zenodo, 2025, ⟨10.5281/zenodo.17409889⟩ Article dans une revue hal-05335858v1
Secretomes From Non-Small Cell Lung Cancer Cells Induce Endothelial Plasticity Through a Partial Endothelial-to-Mesenchymal Transition Clara Bourreau,Emilie Navarro,Marine Cotinat,Morgane Krejbich,François Guillonneauet al. Cancer Medicine, 2025, ⟨10.1002/cam4.70707⟩ Article dans une revue hal-04978598v1
Integrated single-cell RNA-seq analysis reveals mitochondrial calcium signaling as a modulator of endothelial-to-mesenchymal transition. Mathilde Lebas,Giorgia Chinigò,Evan Courmont,Louay Bettaieb,Amani Machmouchiet al. Science Advances , 2024, Sci Adv, 10 (32), eadp6182. ⟨10.1126/sciadv.adp6182⟩ Article dans une revue hal-04711617v1
The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells Pauline de Zeeuw,Lucas Treps,Melissa García-Caballero,Ulrike Harjes,Joanna Kaluckaet al. Communications Biology, 2024, 7 (1), pp.618. ⟨10.1038/s42003-024-06186-6⟩ Article dans une revue inserm-05169224v1
Single‐cell RNA sequencing of cystic fibrosis liver disease explants reveals endothelial complement activation Mathias Declercq,Lucas Treps,Vincent Geldhof,Nadine V Conchinha,Laura P M H de Rooijet al. Liver International, 2024, 44 (9), pp.2382-2395. ⟨10.1111/liv.15963⟩ Article dans une revue inserm-05169218v1
Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment Camille Chatelain,Laurine Berland,Marion Grard,Nicolas Jouand,Judith Fresquetet al. OncoImmunology, 2024, 13 (1), pp.2377830. ⟨10.1080/2162402x.2024.2377830⟩ Article dans une revue inserm-04652311v1
Use of non-small cell lung cancer multicellular tumor spheroids to study the impact of chemotherapy Pauline Hulo,Sophie Deshayes,Judith Fresquet,Anne-Laure Chéné,Stéphanie Blandinet al. Respiratory Research, 2024, 25 (1), pp.156. ⟨10.1186/s12931-024-02791-5⟩ Article dans une revue inserm-04537685v1
Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies Clara Bourreau,Lucas Treps,Sébastien Faure,Delphine Fradin,Nicolas Clere Pharmacology & Therapeutics, 2023, pp.108347. ⟨10.1016/j.pharmthera.2023.108347⟩ Article dans une revue hal-03944679v1
Editorial: Tumor Vessels as Directors of the Tumor Microenvironment: New Findings, Current Challenges & Perspectives Lucas Treps,Ann Ager,Kyoko Hida Frontiers in Cell and Developmental Biology, 2022, 10, pp.885670. ⟨10.3389/fcell.2022.885670⟩ Article dans une revue inserm-05169236v1
Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast Vincent Geldhof,Laura P M H de Rooij,Liliana Sokol,Jacob Amersfoort,Maxim de Schepperet al. Nature Communications, 2022, 13 (1), pp.5511. ⟨10.1038/s41467-022-33052-y⟩ Article dans une revue inserm-05169233v1
Protocols for endothelial cell isolation from mouse tissues: small intestine, colon, heart, and liver Liliana Sokol,Vincent Geldhof,Melissa García-Caballero,Nadine V Conchinha,Sébastien J Dumaset al. STAR Protocols, 2021, 2 (2), pp.100489. ⟨10.1016/j.xpro.2021.100489⟩ Article dans une revue inserm-05169282v1
Comparative meta-analysis of cystic fibrosis cell models suggests partial endothelial-to-mesenchymal transition Lucas Treps,Mathias Declercq,Siham Bousfia,Peter Carmeliet,Peter Witters Journal of Cystic Fibrosis, 2021, pp.S1569-1993(21)00101-6. ⟨10.1016/j.jcf.2021.03.019⟩ Article dans une revue inserm-03349936v1
Vasculogenic mimicry, a complex and devious process favoring tumorigenesis -Interest in making it a therapeutic target Lucas Treps,Sébastien Faure,Nicolas Clere Pharmacology & Therapeutics Part A Chemotherapy Toxicology and Metabolic Inhibitors, 2021, 223, pp.107805. ⟨10.1016/j.pharmthera.2021.107805⟩ Article dans une revue inserm-03349934v1
Tumor vessel co-option probed by single-cell analysis Laure-Anne Teuwen,Laura P M H de Rooij,Anne Cuypers,Katerina Rohlenova,Sébastien J Dumaset al. Cell Reports, 2021, 35 (11), pp.109253. ⟨10.1016/j.celrep.2021.109253⟩ Article dans une revue inserm-05169278v1
Protocols for endothelial cell isolation from mouse tissues: brain, choroid, lung, and muscle Nadine V Conchinha,Liliana Sokol,Laure-Anne Teuwen,Koen Veys,Sébastien J Dumaset al. STAR Protocols, 2021, 2 (3), pp.100508. ⟨10.1016/j.xpro.2021.100508⟩ Article dans une revue inserm-05169243v1
Endothelial CFTR dysfunction and its involvement in the pathogenesis of pulmonary arterial hypertension Mathias Declercq,Lucas Treps,Siham Bousfia,Peter Carmeliet,Peter Witters European Respiratory Journal, 2021, 58 (2), pp.2101645. ⟨10.1183/13993003.01645-2021⟩ Article dans une revue inserm-03349937v1
Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype Mathias Declercq,Pauline de Zeeuw,Nadine V Conchinha,Vincent Geldhof,Anabela S Ramalhoet al. European Respiratory Journal, 2021, 57 (4), pp.2000261. ⟨10.1183/13993003.00261-2020⟩ Article dans une revue inserm-05169290v1
Protocols for endothelial cell isolation from mouse tissues: kidney, spleen, and testis Sébastien J Dumas,Elda Meta,Nadine V Conchinha,Liliana Sokol,Rongyuan Chenet al. STAR Protocols, 2021, 2 (3), pp.100523. ⟨10.1016/j.xpro.2021.100523⟩ Article dans une revue inserm-05169267v1
Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation Ulrike Bruning,Francisco Morales-Rodriguez,Joanna Kalucka,Jermaine Goveia,Federico Tavernaet al. Cell Metabolism, 2021, 28 (6), pp.866 - 880.e15. ⟨10.1016/j.cmet.2018.07.019⟩ Article dans une revue inserm-05169365v1
Basic and Therapeutic Aspects of Angiogenesis Updated Guy Eelen,Lucas Treps,Xuri Li,Peter Carmeliet Circulation Research, 2020, 127 (2), pp.310-329. ⟨10.1161/CIRCRESAHA.120.316851⟩ Article dans une revue inserm-05169300v1
Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers Lyna Kara-Terki,Lucas Treps,Christophe Blanquart,Delphine Fradin International Journal of Molecular Sciences, 2020, 21 (17), pp.6024. ⟨10.3390/ijms21176024⟩ Article dans une revue inserm-02946311v1
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis Katerina Rohlenova,Jermaine Goveia,Melissa García-Caballero,Abhishek Subramanian,Joanna Kaluckaet al. Cell Metabolism, 2020, 31 (4), pp.862-877. ⟨10.1016/j.cmet.2020.03.009⟩ Article dans une revue inserm-05169310v1
BIOMEX: an interactive workflow for (single cell) omics data interpretation and visualization Federico Taverna,Jermaine Goveia,Tobias K Karakach,Shawez Khan,Katerina Rohlenovaet al. Nucleic Acids Research, 2020, 48 (W1), pp.W385-W394. ⟨10.1093/nar/gkaa332⟩ Article dans une revue inserm-05169304v1
Single-Cell Transcriptome Atlas of Murine Endothelial Cells Joanna Kalucka,Laura P M H de Rooij,Jermaine Goveia,Katerina Rohlenova,Sébastien J Dumaset al. Cell, 2020, 180 (4), pp.764-779. ⟨10.1016/j.cell.2020.01.015⟩ Article dans une revue inserm-05169319v1
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates Jermaine Goveia,Katerina Rohlenova,Federico Taverna,Lucas Treps,Lena-Christin Conradiet al. Cancer Cell, 2020, 37 (1), pp.21-36. ⟨10.1016/j.ccell.2019.12.001⟩ Article dans une revue inserm-05169323v1
BRAF, A gatekeeper controlling endothelial permeability Mathias Declercq,Lucas Treps FEBS Journal, 2019, 286 (12), pp.2273 - 2276. ⟨10.1111/febs.14861⟩ Article dans une revue inserm-05169328v1
EndoDB: a database of endothelial cell transcriptomics data Shawez Khan,Federico Taverna,Katerina Rohlenova,Lucas Treps,Vincent Geldhofet al. Nucleic Acids Research, 2018, 47 (D1), pp.D736 - D744. ⟨10.1093/nar/gky997⟩ Article dans une revue inserm-05169336v1
Endothelial Cell Metabolism Guy Eelen,Pauline de Zeeuw,Lucas Treps,Ulrike Harjes,Brian Wonget al. Physiological Reviews, 2018, 98 (1), pp.3-58. ⟨10.1152/physrev.00001.2017⟩ Article dans une revue inserm-05169374v1
RAISEing VEGF-D’s importance as predictive biomarker for ramucirumab in metastatic colorectal cancer patients P. Carmeliet,Xiaojian Li,Lucas Treps,L-C Conradi,S Loges Annals of Oncology, 2018, 29 (3), pp.529-532. ⟨10.1093/annonc/mdy028⟩ Article dans une revue hal-02047270v1
EnLIGHTenment of tumor vessel normalization and immunotherapy in glioblastoma Lucas Treps Journal of Pathology, 2018, 246 (1), pp.3 - 6. ⟨10.1002/path.5103⟩ Article dans une revue inserm-05169367v1
Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis Joanna Kalucka,Laura Bierhansl,Nadine Vasconcelos Conchinha,Rindert Missiaen,Ilaria Eliaet al. Cell Metabolism, 2018, 28 (6), pp.881 - 894. ⟨10.1016/j.cmet.2018.07.016⟩ Article dans une revue inserm-05169358v1
Endothelial cell metabolism in health and disease: impact of hypoxia Brian W Wong,Elke Marsch,Lucas Treps,Myriam Baes,Peter Carmeliet EMBO Journal, 2017, 36 (15), pp.2187 - 2203. ⟨10.15252/embj.201696150⟩ Article dans une revue inserm-05169389v1
Central Role of Metabolism in Endothelial Cell Function and Vascular Disease Laura Bierhansl,Lena-Christin Conradi,Lucas Treps,Mieke Dewerchin,Peter Carmeliet Physiology, 2017, 32 (2), pp.126 - 140. ⟨10.1152/physiol.00031.2016⟩ Article dans une revue inserm-05170115v1
Assaying the Action of Secreted Semaphorins on Vascular Permeability Lucas Treps,Julie Gavard Methods in Molecular Biology, 2017, ⟨10.1007/978-1-4939-6448-2_30⟩ Article dans une revue inserm-01662346v1
Glioblastoma stem‐like cells secrete the pro‐angiogenic VEGF‐A factor in extracellular vesicles Lucas Treps,Raul Perret,Sébastien Edmond,Damien Ricard,Julie Gavard Journal of Extracellular Vesicles, 2017, 6 (1), pp.1359479. ⟨10.1080/20013078.2017.1359479⟩ Article dans une revue hal-04963388v1
Endothelial cell metabolism: A novel player in atherosclerosis? Basic principles and therapeutic opportunities Andreas Pircher,Lucas Treps,Natalia Bodrug,Peter Carmeliet Atherosclerosis, 2016, 253, pp.247 - 257. ⟨10.1016/j.atherosclerosis.2016.08.011⟩ Article dans une revue inserm-05170187v1
Manipulating Angiogenesis by Targeting Endothelial Metabolism: Hitting the Engine Rather than the Drivers—A New Perspective? Lucas Treps,Lena-Christin Conradi,Ulrike Harjes,Peter Carmeliet Pharmacological Reviews, 2016, 68 (3), pp.872 - 887. ⟨10.1124/pr.116.012492⟩ Article dans une revue inserm-05170192v1
The E3 ubiquitin ligase MARCH3 controls the endothelial barrier Héloïse M Leclair,Gwennan André-Grégoire,Lucas Treps,Sandy Azzi,Nicolas Bidèreet al. FEBS Letters, 2016, 590 (20), pp.3660-3668. ⟨10.1002/1873-3468.12417⟩ Article dans une revue inserm-01385212v1
Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma L Treps,S Edmond,E Harford-Wright,Em Galan-Moya,Anne Schmittet al. Oncogene, 2016, 35, pp.2615 - 2623. ⟨10.1038/onc.2015.317⟩ Article dans une revue inserm-01406334v1
Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy Anna Rita Cantelmo,Lena-Christin Conradi,Aleksandra Brajic,Jermaine Goveia,Joanna Kaluckaet al. Cancer Cell, 2016, 30 (6), pp.968 - 985. ⟨10.1016/j.ccell.2016.10.006⟩ Article dans une revue inserm-05170152v1
The guanine exchange factor SWAP70 mediates vGPCR-induced endothelial plasticity Julie Dwyer,Sandy Azzi,Héloïse M Leclair,Steven Georges,Agnès Carlottiet al. Cell Communication and Signaling, 2015, 13 (1), pp.11. ⟨10.1186/s12964-015-0090-1⟩ Article dans une revue inserm-01264495v1
L'angiogenèse tumorale Quand l'arbre de vie tourne mal Lucas Treps,Julie Gavard Médecine/Sciences, 2015, 31 (11), pp.989 - 995. ⟨10.1051/medsci/20153111013⟩ Article dans une revue inserm-01819799v1
Desert Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in Glioblastoma Sandy Azzi,Lucas Treps,Héloïse M. Leclair,Hai-Mi Ngo,Elizabeth Harford-Wrightet al. Frontiers in Pharmacology, 2015, ⟨10.3389/fphar.2015.00281⟩ Article dans une revue inserm-01247505v1
Endothelial Secreted Factors Suppress Mitogen Deprivation-Induced Autophagy and Apoptosis in Glioblastoma Stem-Like Cells Eva Maria Galan-Moya,Lucas Treps,Lisa Oliver,Hervé Chneiweiss,François M. Valletteet al. PLoS ONE, 2014, pp.e93505. ⟨10.1371/journal.pone.0093505⟩ Article dans une revue inserm-01075054v1
Aberrant methylation of tRNAs links cellular stress to neuro‐developmental disorders Sandra Blanco,Sabine Dietmann,Joana V Flores,Shobbir Hussain,Claudia Kutteret al. EMBO Journal, 2014, 33 (18), pp.2020 - 2039. ⟨10.15252/embj.201489282⟩ Article dans une revue inserm-05170194v1
Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation Armelle Le Guelte,Eva-Maria Galan-Moya,Julie Dwyer,Lucas Treps,Garance Kettleret al. Journal of Cell Science, 2012, 125 (17), pp.4137-4146. ⟨10.1242/jcs.108282⟩ Article dans une revue hal-01541442v1

Pré-publication, Document de travail (1)

In vitro models to mimic tumor endothelial cell-mediated immune cell reprogramming in lung adenocarcinoma Morgane Krejbich,Judith Fresquet,Emilie Navarro,Virginie Forest,Marine Cotinatet al. 2024 Pré-publication, Document de travail (preprint/prepublication) hal-04757165v1

Thèse (1)

Implication des vésicules extracellulaires des cellules initiatrices tumorales dans l’augmentation de la perméabilité vasculaire du glioblastome Lucas Treps Biologie moléculaire. Université Sorbonne Paris Cité, 2015. Français. ⟨NNT : 2015USPCB069⟩ Thèse tel-01228503v1