Lucy Glover Head of Trypanosome Molecular Biology Unit

Publications

Article dans une revue (39)

Division of labor in trypanosome RNA processing and export through expanded Mex67 paralogs Samson Obado,Peter Fridy,Eva Hegedűsová,Trevor van Eeuwen,Milana Steinet al. Nucleic Acids Research, In press, 54 (1), pp.gkaf1443. ⟨10.1093/nar/gkaf1443⟩ Article dans une revue hal-05447852v1
A CRISPR-based diagnostic tool to survey drug resistance in human African trypanosomiasis Elena Pérez Antón,Annick Dujeancourt-Henry,Brice Rotureau,Lucy Glover Antimicrobial Agents and Chemotherapy, In press, pp.e00933-25. ⟨10.1128/aac.00933-25⟩ Article dans une revue hal-05389986v1
A SHERLOCK toolbox for eco-epidemiological surveillance of African trypanosomes in domestic pigs from Western Africa Roger Eloiflin,Elena Pérez-Antón,Aïssata Camara,Annick Dujeancourt-Henry,Salimatou Boiroet al. eLife, 2025, 14, pp.RP106823. ⟨10.7554/eLife.106823⟩ Article dans une revue hal-05273604v2
Phosphoproteomic analysis of the response to DNA damage in Trypanosoma brucei Emilia Mclaughlin,Monica Gabriela Zavala Martinez,Annick Dujeancourt-Henry,Thibault Chaze,Quentin Giai Gianettoet al. Journal of Biological Chemistry, 2024, 300 (9), pp.107657. ⟨10.1016/j.jbc.2024.107657⟩ Article dans une revue pasteur-04854518v1
Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome Monica Chandra,Sara Đaković,Konstantina Foti,Johan Zeelen,Monique van Straatenet al. PLoS Neglected Tropical Diseases, 2023, 17 (2), pp.e0011093. ⟨10.1371/journal.pntd.0011093⟩ Article dans une revue hal-05273629v1
Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei Emilia Jane Mclaughlin,Karinna Rubio-Pena,Annick Dujeancourt-Henry,Lucy Glover mBio, 2022, 13 (2), pp.e0384721. ⟨10.1128/mbio.03847-21⟩ Article dans une revue pasteur-03647000v1
VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei Eliane Tihon,Karinna Rubio-Peña,Annick Dujeancourt-Henry,Aline Crouzols,Brice Rotureauet al. Frontiers in Cell and Developmental Biology, 2022, 10, pp.851475. ⟨10.3389/fcell.2022.851475⟩ Article dans une revue pasteur-03646994v1
SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African Trypanosomiasis Núria Sima,Annick Dujeancourt-Henry,Blanca Liliana Perlaza,Marie-Noelle Ungeheuer,Brice Rotureauet al. EBioMedicine, 2022, 85, pp.104308. ⟨10.1016/j.ebiom.2022.104308⟩ Article dans une revue pasteur-04073409v1
Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes Joana Faria,Vanessa Luzak,Laura Müller,Benedikt Brink,Sebastian Hutchinsonet al. Nature Microbiology, 2021, 6 (3), pp.289-300. ⟨10.1038/s41564-020-00833-4⟩ Article dans une revue hal-05130106v1
The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes Ann-Kathrin Mehnert,Marco Prorocic,Annick Dujeancourt-Henry,Sebastian Hutchinson,Richard Mccullochet al. Nucleic Acids Research, 2021, ⟨10.1093/nar/gkaa1265⟩ Article dans une revue pasteur-03112362v1
DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice Alix Thivolle,Ann-Kathrin Mehnert,Eliane Tihon,Emilia Mclaughlin,Annick Dujeancourt-Henryet al. PLoS Pathogens, 2021, 17 (11), pp.e1010038. ⟨10.1371/journal.ppat.1010038⟩ Article dans une revue pasteur-04073401v1
mSphere of Influence: Expanding the CRISPR Sphere with Single-Locus Proteomics Lucy Glover MSphere, 2020, 5 (1), ⟨10.1128/mSphere.00001-20⟩ Article dans une revue pasteur-03107138v1
CRISPR in Parasitology: Not Exactly Cut and Dried! Jessica Bryant,Sebastian Baumgarten,Lucy Glover,Sebastian Hutchinson,Najma Rachidi Trends in Parasitology, 2019, 35 (6), pp.409-422. ⟨10.1016/j.pt.2019.03.004⟩ Article dans une revue pasteur-02874588v1
Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome Lucy Glover,Catarina Marques,Olga Suska,David Horn mBio, 2019, 10 (4), pp.e01252-19. ⟨10.1128/mBio.01252-19⟩ Article dans une revue pasteur-03107118v1
A post-transcriptional respiratome regulon in trypanosomes Anna Trenaman,Lucy Glover,Sebastian Hutchinson,David Horn Nucleic Acids Research, 2019, 47 (13), pp.7063-7077. ⟨10.1093/nar/gkz455⟩ Article dans une revue pasteur-03107129v1
Escaping the immune system by DNA repair and recombination in African trypanosomes Núria Sima,Emilia Jane Mclaughlin,Sebastian Hutchinson,Lucy Glover Open Biology, 2019, 9 (11), pp.190182. ⟨10.1098/rsob.190182⟩ Article dans une revue pasteur-03107126v1
Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex Joana Faria,Lucy Glover,Sebastian Hutchinson,Cordula Boehm,Mark Fieldet al. Nature Communications, 2019, 10 (1), pp.3023. ⟨10.1038/s41467-019-10823-8⟩ Article dans une revue pasteur-03107015v1
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling James Thomas,Nicola Baker,Sebastian Hutchinson,Caia Dominicus,Anna Trenamanet al. PLoS Neglected Tropical Diseases, 2018, 12 (11), pp.e0006980. ⟨10.1371/journal.pntd.0006980⟩ Article dans une revue pasteur-03107158v1
Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei Eva Rico,Alasdair Ivens,Lucy Glover,David Horn,Keith Matthews PLoS Pathogens, 2017, 13 (3), pp.e1006279. ⟨10.1371/journal.ppat.1006279⟩ Article dans une revue pasteur-03107156v1
High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes Sebastian Hutchinson,Lucy Glover,David Horn BMC Genomics, 2016, 17 (1), pp.806. ⟨10.1186/s12864-016-3154-8⟩ Article dans une revue pasteur-03107120v1
The nuclear envelope and gene organization in parasitic protozoa: Specializations associated with disease Samson Obado,Lucy Glover,Kirk Deitsch Molecular and Biochemical Parasitology, 2016, 209 (1-2), pp.104-113. ⟨10.1016/j.molbiopara.2016.07.008⟩ Article dans une revue pasteur-03107121v1
VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes Lucy Glover,Sebastian Hutchinson,Sam Alsford,David Horn Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (26), pp.7225-7230. ⟨10.1073/pnas.1600344113⟩ Article dans une revue pasteur-03107112v1
Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes Lucy Glover,Sam Alsford,Nicola Baker,Daniel Turner,Alejandro Sanchez-Floreset al. Nature Protocols, 2015, 10 (1), pp.106-133. ⟨10.1038/nprot.2015.005⟩ Article dans une revue pasteur-03107102v1
Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome Lucy Glover,David Horn Nucleic Acids Research, 2014, 42 (20), pp.12600-12613. ⟨10.1093/nar/gku900⟩ Article dans une revue pasteur-03107111v1
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs Jane Munday,Anthonius Eze,Nicola Baker,Lucy Glover,Caroline Clucaset al. Journal of Antimicrobial Chemotherapy, 2014, 69 (3), pp.651-663. ⟨10.1093/jac/dkt442⟩ Article dans une revue pasteur-03107152v1
PPL2 Translesion Polymerase Is Essential for the Completion of Chromosomal DNA Replication in the African Trypanosome Sean Rudd,Lucy Glover,Stanislaw Jozwiakowski,David Horn,Aidan J Doherty Molecular Cell, 2013, 52 (4), pp.554-565. ⟨10.1016/j.molcel.2013.10.034⟩ Article dans une revue pasteur-03107124v1
DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes Lucy Glover,Sam Alsford,David Horn PLoS Pathogens, 2013, 9 (3), pp.e1003260. ⟨10.1371/journal.ppat.1003260⟩ Article dans une revue pasteur-03107107v1
Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control Lucy Glover,Sebastian Hutchinson,Sam Alsford,Richard Mcculloch,Mark Fieldet al. Cellular Microbiology, 2013, 15 (12), pp.1984-1993. ⟨10.1111/cmi.12215⟩ Article dans une revue pasteur-03107113v1
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes Nicola Baker,Lucy Glover,Jane Munday,David Aguinaga Andres,Michael P Barrettet al. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (27), pp.10996-11001. ⟨10.1073/pnas.1202885109⟩ Article dans une revue pasteur-03107134v1
Trypanosomal histone γH2A and the DNA damage response Lucy Glover,David Horn Molecular and Biochemical Parasitology, 2012, 183 (1), pp.78-83. ⟨10.1016/j.molbiopara.2012.01.008⟩ Article dans une revue pasteur-03107110v1
High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Sam Alsford,Daniel Turner,Samson Obado,Alejandro Sanchez-Flores,Lucy Gloveret al. Genome Research, 2011, 21 (6), pp.915-924. ⟨10.1101/gr.115089.110⟩ Article dans une revue pasteur-03107133v1
Microhomology-mediated deletion and gene conversion in African trypanosomes Lucy Glover,Junho Jun,David Horn Nucleic Acids Research, 2011, 39 (4), pp.1372-1380. ⟨10.1093/nar/gkq981⟩ Article dans une revue pasteur-03107115v1
DNA breaks as triggers for antigenic variation in African trypanosomes Sam Alsford,David Horn,Lucy Glover Genome Biology, 2009, 10 (6), pp.223. ⟨10.1186/gb-2009-10-6-223⟩ Article dans une revue pasteur-03107131v1
Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei Lucy Glover,David Horn Molecular and Biochemical Parasitology, 2009, 166 (2), pp.194-197. ⟨10.1016/j.molbiopara.2009.03.010⟩ Article dans une revue pasteur-03107140v1
Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes Lucy Glover,Richard Mcculloch,David Horn Nucleic Acids Research, 2008, 36 (8), pp.2608-2618. ⟨10.1093/nar/gkn104⟩ Article dans une revue pasteur-03107119v1
Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest Lucy Glover,Sam Alsford,Caroline Beattie,David Horn Nucleic Acids Research, 2007, 35 (3), pp.872-880. ⟨10.1093/nar/gkl1100⟩ Article dans une revue pasteur-03107105v1
Repression of polymerase I‐mediated gene expression at Trypanosoma brucei telomeres Lucy Glover,David Horn EMBO Reports, 2006, 7 (1), pp.93-99. ⟨10.1038/sj.embor.7400575⟩ Article dans une revue pasteur-03107108v1
Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects Sam Alsford,Taemi Kawahara,Lucy Glover,David Horn Molecular and Biochemical Parasitology, 2005, 144 (2), pp.142-148. ⟨10.1016/j.molbiopara.2005.08.009⟩ Article dans une revue pasteur-03107132v1
Multiplex analysis of RNA interference defects in Trypanosoma brucei Sam Alsford,Lucy Glover,David Horn Molecular and Biochemical Parasitology, 2005, 139 (1), pp.129-132. ⟨10.1016/j.molbiopara.2004.11.001⟩ Article dans une revue pasteur-03107009v1

Communication dans un congrès (2)

SHERLOCK4AAT, a new molecular method for highly sensitive and specific detection of animal African trypanosomes Roger Junior Eloiflin,Elena Perez Anton,Aïssata Camara,Annick Dujeancourt Henry,Jean Mathieu Bartet al. Pasteur Network Annual Meeting, Pasteur Network, Oct 2025, Ho chi Minh city, Vietnam Communication dans un congrès hal-05415525v1
SHERLOCK4HAT: A CRISPR based toolkit for diagnosis of Human African Trypanosomiasis Lucy Glover INSTITUT PASTEUR/UCSF QBI THIRD ANNUAL SYMPOSIUM ON INFECTIOUS DISEASES, Drs. Carla Saleh and Nevan Krogan,, Apr 2023, Paris, France Communication dans un congrès hal-05392418v1

Poster de conférence (2)

SHERLOCK4AAT, a new molecular method for highly sensitive and specific detection of animal African trypanosomes Aïssata Camara,Elena Perez Anton,Roger Junior Eloiflin,Annick Dujeancourt Henry,Martial Kassi N'Djetchiet al. SHERLOCK4AAT, a new molecular method for highly sensitive and specific detection of animal African trypanosomes, Oct 2024, Conakry, Guinea Poster de conférence hal-05415549v1
Development of a molecular diagnostic toolbox for the detection of trypanosomatid parasites by SHERLOCK Elena Pérez Antón,Lucy Glover,Brice Rotureau,Jean-Mathieu Bart,Aïssata Camaraet al. Ninth Kinetoplastid Molecular Cell Biology Meeting, Sep 2022, Woods Hole, Massachusetts, USA, United States Poster de conférence hal-05407247v1

Chapitre d'ouvrage (1)

Forward Genetics in African Trypanosomes Sebastian Hutchinson,Lucy Glover Trypanosomatids, 2116, pp.339-352, 2020, Methods in Molecular biology, 978-1-0716-0294-2 (online) ; 978-1-0716-0293-5 (print). ⟨10.1007/978-1-0716-0294-2_21⟩ Chapitre d'ouvrage pasteur-03107149v1