MAELLE CARRAZ CRCN IRD at MCD and PHARMADEV

Présentation

I’m a chemical biologist and a natural product (NP) expert working on plant-biodiversity and its use in many fields of biology. I am performing both analytical chemistry for new NPs identification and cell biology to develop original assays for NPs bioactivity/ phenotypic screening. I am also developing projects dealing with epigenetics and cellular senescence. I set up a team (Jeune Equipe Associée à l’IRD, 2020-22) in IRSS Burkina Faso (Africa) to perform cellular assays on plants used in traditional medicine. I am coordinating several projects at the chemistry-biology interface.

Publications

Article dans une revue (18)

Comparative analysis of the regulations for the marketing and quality control of herbal products used for health purposes in France, Peru and West Africa Inés Yolanda Castro-Dionicio,Charlotte Dumondin,Latifou Lagnika,Nicolas Fabre,Rokia Sanogoet al. Tropical Medicine and International Health, 2025, ⟨10.1111/tmi.70061⟩ Article dans une revue hal-05360707v1
Corrigendum to “Triterpenoid saponins from Calliandra calothyrsus Meisn. and their antiproliferative activity against two digestive carcinoma human cell lines” [Fitoterapia volume 146 (2020) p1-9/article 104669] Lin Marcellin Messi,Olivier Placide Noté,Joséphine Ngo Mbing,Pierre Lavedan,Marc Vedrenneet al. Fitoterapia, 2024, 175, pp.105934. ⟨10.1016/j.fitote.2024.105934⟩ Article dans une revue hal-04726040v1
Liver cancer antiproliferative activity of a new nor-cucurbitacin from Mareya micrantha Müll. Arg. Gnaoré Yoh Toussaint-Douhoré,Yaya Soro,Noufou Ouédraogo,Carlos Vaca-Garcia,Barthélemy Koffi-Attiouaet al. Fitoterapia, 2023, 166, pp.105471. ⟨10.1016/j.fitote.2023.105471⟩ Article dans une revue hal-04056446v1
Polyphenol content, antioxidant and antiproliferative effects of a plant mixture composed of four medicinal plants with hepatoprotective potential Rainatou Boly,Abdourahim Kindo,Tata Kadiatou Traore,Wendkouni Leila M. Esther Belem-Kabre,Lassina Barroet al. African Journal of Pharmacy and Pharmacology, 2023, 17 (9), pp.182-190. ⟨10.5897/ajpp2023.5369⟩ Article dans une revue hal-04738389v1
Potent antiplasmodial derivatives of dextromethorphan reveal the ent-morphinan pharmacophore of tazopsine-type alkaloids Antoinette Keita,Jean-François Franetich,Maëlle Carraz,Loïse Valentin,Mallaury Bordessouleset al. Pharmaceutics, 2022, 14 (2), pp.372. ⟨10.3390/pharmaceutics14020372⟩ Article dans une revue hal-03594207v1
Triterpenoid saponins from Calliandra calothyrsus Meisn. and their antiproliferative activity against two digestive carcinoma human cell lines Lin Marcellin Messi,Olivier Placide Noté,Joséphine Ngo Mbing,Pierre Lavedan,Marc Vedrenneet al. Fitoterapia, 2020, 146, pp.104669 -. ⟨10.1016/j.fitote.2020.104669⟩ Article dans une revue hal-03490857v1
Countrywide Survey of Plants Used for Liver Disease Management by Traditional Healers in Burkina Faso André Tibiri,Sébastien Boria,Tata Kadiatou Traoré,Noufou Ouédraogo,Aude Nikièmaet al. Frontiers in Pharmacology, 2020, 11, pp.563751. ⟨10.3389/fphar.2020.563751⟩ Article dans une revue hal-03549227v1
XANTHONES FROM Hypericum laricifolium Juss., AND THEIR ANTIPROLIFERATIVE ACTIVITY AGAINST HEP3B CELLS. Moisela Marlon Miguel Morales,Brel Orianne,Bourdy Geneviève,Cruza Mercedes Gonzales de La,Dionicio Inés Yolanda Castroet al. Rev Soc Quím Perú. , 2018 Article dans une revue hal-04738484v1
Phenolic Compounds Isolated from Caesalpinia coriaria Induce S and G2/M Phase Cell Cycle Arrest Differentially and Trigger Cell Death by Interfering with Microtubule Dynamics in Cancer Cell Lines Jessica Nayelli Sánchez-Carranza,Laura Alvarez,Silvia Marquina-Bahena,Enrique Salas-Vidal,Verónica Cuevaset al. Molecules, 2017, 22 (4), pp.666. ⟨10.3390/molecules22040666⟩ Article dans une revue hal-03152330v1
MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence Raphael Culerrier,Maëlle Carraz,Carl Mann,Malek Djabali Molecular Biology of the Cell, 2016, 27 (17), pp.2726 - 2734. ⟨10.1091/mbc.E15-11-0772⟩ Article dans une revue hal-01412354v1
Antiproliferative activity and phenotypic modification induced by selected Peruvian medicinal plants on human hepatocellular carcinoma Hep3B cells Maëlle Carraz,Cédric Lavergne,Valérie Jullian,Michel Wright,Jean Edouard Gairinet al. Journal of Ethnopharmacology, 2015, 166, pp.185-199. ⟨10.1016/j.jep.2015.02.028⟩ Article dans une revue istex hal-04738492v1
Synthesis, Structures, and Biological Studies of Heterobimetallic Au(I)–Ru(II) Complexes Involving N-Heterocyclic Carbene-Based Multidentate Ligands Luca Boselli,Maëlle Carraz,Serge Mazères,Lucie Paloque,Germán Gonzálezet al. Organometallics, 2015, 34 (6), pp.1046-1055. ⟨10.1021/om501158m⟩ Article dans une revue hal-04738497v1
Synthesis, structures, and biological studies of heterobimetallic Au(I)-Ru(II) complexes involving N-heterocyclic carbene-based multidentate ligands Luca Boselli,Maëlle Carraz,S. Mazeres,Lucie Paloque,German Gonzalez-Aspajoet al. Organometallics, 2015, 34 (6), pp.1046-1055. ⟨10.1021/om501158m⟩ Article dans une revue hal-01925137v1
Synthesis, structures, and selective toxicity to cancer cells of gold(I) complexes involving N-heterocyclic carbene ligands Luca Boselli,Isabelle Ader,Maëlle Carraz,Catherine Hemmert,Olivier Cuvillieret al. European Journal of Medicinal Chemistry, 2014, 85, pp.87-94. ⟨10.1016/j.ejmech.2014.07.086⟩ Article dans une revue istex hal-02007936v1
Synthesis and cytotoxic activity of a novel dihydroisoquinoline-derived hydroxamic acid Hassen Ben Salah,Maëlle Carraz,Majed Kammoun Journal of Advances in Chemistry, 2014, 10 (4), pp.2648-2653. ⟨10.24297/jac.v10i4.5503⟩ Article dans une revue hal-04741099v1
In vitro growth inhibitory effects of 13,28-epoxyoleanane triterpene saponins in cancer cells Mohamed Haddad,Anne-Cécile Lelamer,Laetitia Moreno Y Banuls,Pedro Vasquez,Maëlle Carrazet al. Phytochemistry Letters, 2013, 6 (1), pp.128-134. ⟨10.1016/j.phytol.2012.11.011⟩ Article dans une revue istex hal-04741121v1
A plant-derived morphinan as a novel lead compound active against malaria liver stages. Maëlle Carraz,Akino Jossang,Jean-François Franetich,Anthony Siau,Liliane Ciceronet al. PLoS Medicine, 2006, 3 (12), pp.e513. ⟨10.1371/journal.pmed.0030513⟩ Article dans une revue hal-00148373v1
Design and synthesis of novel imidazo[1,2- a ]quinoxalines as PDE4 inhibitors Carine Deleuze-Masquéfa,Grégori Gerebtzoff,Guy Subra,Jean-Roch Fabreguettes,Annabel Ovenset al. Bioorganic and Medicinal Chemistry, 2004, 12 (5), pp.1129-1139. ⟨10.1016/j.bmc.2003.11.034⟩ Article dans une revue istex hal-04741189v1

Logiciel (1)

Cantharella: Pharmacochemical database of natural products Sylvain Petek,Adrien Cheype,Mickael Tricot,Alban Diguer,Benjamin Poussinet al. 2025, ⟨swh:1:dir:9f92e6d05f166af5f85d894a855959ea15adf037;origin=https://hal.archives-ouvertes.fr/hal-01887126;visit=swh:1:snp:8b76375800ed21f2a235d58470eeb9789deaf856;anchor=swh:1:rel:df5c9bfca7186c05e79a4fc063fe6b52d88c3167;path=/⟩ Logiciel hal-01887126v3

Chapitre d'ouvrage (1)

Gestion des maladies hépatiques et plantes utilisées par les tradipraticiens au Burkina Faso. A Tibiri,S Boria,Tk Traoré,N Ouédraogo,A Nikièmaet al. Biodiversité et Développement Durable, 2021 Chapitre d'ouvrage hal-04738449v1

Ouvrages (1)

Tazopsine et dérivés actifs contre le stade hépatique de Plasmodium. Maëlle Carraz 2012 Ouvrages hal-04741130v1

Brevet (1)

Alkaloids for treatment of paludism. Maëlle Carraz,Maëlle Carraz,Akino Jossang,Philippe Rasoanaivo,Jean-François Franetichet al. France, Patent n° : N° PCT/EP 2005/005239. 2005 Brevet hal-04741166v1