marc since

Publications

Article dans une revue (35)

Access to novel potent pleiotropic prodrugs, targeting both butyrylcholinesterase and serotonin reuptake, with anti-amnesic activities in Alzheimer's disease model Valentin Travers--Lesage,Lucie Crouzier,Mirjana Antonijevic,Alice Wang,François-Xavier Toubletet al. European Journal of Medicinal Chemistry, 2026, 307, pp.118670. ⟨10.1016/j.ejmech.2026.118670⟩ Article dans une revue hal-05576481v1
Polyfunctionalized N-Arylsulfonyl Indoles: Identification of (E)-N-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1H-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-based Therapy of Parkinson’s Disease Mireia Toledano-Pinedo,Alicia Porro-Pérez,Linda Schäker-Hübner,Daniel Diez-Iriepa,Isabel Iriepaet al. International Journal of Molecular Sciences, 2026, 27 (7), pp.3135. ⟨10.3390/ijms27073135⟩ Article dans une revue hal-05577025v1
Implication of Central β 2 Adrenergic Receptor for the Development of Novel Drugs Against Alzheimer's Disease Alice Wang,Marc Since,Patrick Dallemagne,Christophe Rochais Archiv der Pharmazie / Chemistry in Life Sciences, 2025, 358 (4), ⟨10.1002/ardp.202400750⟩ Article dans une revue hal-05020271v1
Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential Omar Khoumeri,Sébastien Hutter,Nicolas Primas,Caroline Castera-Ducros,Sandra Carvalhoet al. Pharmaceuticals, 2024, 17 (7), pp.878. ⟨10.3390/ph17070878⟩ Article dans une revue hal-04635068v1
Towards New Anti‐inflammatory Agents: Design, Synthesis and Evaluation of Molecules Targeting XIAP‐BIR2 Marc Ragui Farag,Nicolas Guedeney,Florian Schwalen,Aymeric Zadorovnyj,Amelie Barczyket al. ChemMedChem, 2024, pp.e202400567. ⟨10.1002/cmdc.202400567⟩ Article dans une revue hal-04772005v1
Disruption of PHF6 Peptide Aggregation from Tau Protein: Mechanisms of Palmatine Chloride in Preventing Early PHF6 Aggregation Charline Fagnen,Johanna Giovannini,Thomas Vignol,Marc Since,Marco Cattoet al. ACS Chemical Neuroscience, 2024, 15 (21), pp.3981-3990. ⟨10.1021/acschemneuro.4c00353⟩ Article dans une revue hal-04847910v1
Molecular glue degraders: exciting opportunities for novel drug discovery Thomas Lemaitre,Marie Cornu,Florian Schwalen,Marc Since,Charline Kiefferet al. Expert Opinion on Drug Discovery, 2024, 19 (4), pp.433-449. ⟨10.1080/17460441.2024.2306845⟩ Article dans une revue hal-04711906v1
A biomimetic multiparametric assay to characterise anti-amyloid drugs Willy Smeralda,Marc Since,Sophie Corvaisier,Dimitri Fayoll,Julien Cardinet al. International Journal of Molecular Sciences, 2023, 24 (23), pp.16982. ⟨10.3390/ijms242316982⟩ Article dans une revue hal-04315267v1
Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy Romain Mustière,Prisca Lagardère,Sébastien Hutter,Viviana Dell’orco,Nadia Amanzougagheneet al. European Journal of Medicinal Chemistry, 2022, 241, pp.114619. ⟨10.1016/j.ejmech.2022.114619⟩ Article dans une revue hal-03737417v1
Star-like poly(peptoid)s with selective antibacterial activity Pedro Salas-Ambrosio,Antoine Tronnet,Mostafa Badreldin,Luzangel Reyes,Marc Sinceet al. Polymer Chemistry, 2022, 13 (5), pp.600-612. ⟨10.1039/D1PY01529J⟩ Article dans une revue hal-03559890v1
Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial Pharmacophore Romain Paoli-Lombardo,Nicolas Primas,Sandra Bourgeade-Delmas,Sébastien Hutter,Alix Sournia-Saquetet al. Pharmaceuticals, 2022, 15 (8), pp.998. ⟨10.3390/ph15080998⟩ Article dans une revue hal-03755519v1
A functional m 6 A‐RNA methylation pathway in the oyster Crassostrea gigas assumes epitranscriptomic regulation of lophotrochozoan development Lorane Le Franc,Benoit Bernay,Bruno Petton,Marc Since,Pascal Favrelet al. FEBS Journal, 2021, 288 (5), pp.1696-1711. ⟨10.1111/febs.15500⟩ Article dans une revue hal-02952460v1
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease François-Xavier Toublet,Julien Lalut,Bérénice Hatat,Cédric Lecoutey,Audrey Daviset al. European Journal of Medicinal Chemistry, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩ Article dans une revue hal-03082877v1
β-Amyloid peptide interactions with biomimetic membranes: A multiparametric characterization Willy Smeralda,Marc Since,Julien Cardin,Sophie Corvaisier,Sophie Lecomteet al. International Journal of Biological Macromolecules, 2021, 181, pp.769-777. ⟨10.1016/j.ijbiomac.2021.03.107⟩ Article dans une revue hal-03187852v1
Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones Pedro Salas-Ambrosio,Antoine Tronnet,Marc Since,Sandra Bourgeade-Delmas,Jean-Luc Stiglianiet al. Journal of the American Chemical Society, 2021, 143 (10), pp.3697-3702. ⟨10.1021/jacs.0c13231⟩ Article dans une revue hal-03173586v1
Pyridoclax-loaded nanoemulsion for enhanced anticancer effect on ovarian cancer A.C. Groo,S. Hedir,M. Since,E. Brotin,L.-B. Weiswaldet al. International Journal of Pharmaceutics, 2020, 587, pp.119655 -. ⟨10.1016/j.ijpharm.2020.119655⟩ Article dans une revue hal-03492393v1
New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi Julien Pedron,Clotilde Boudot,Jean-Yves Brossas,Emilie Pinault,Sandra Bourgeade-Delmaset al. ACS Medicinal Chemistry Letters, 2020, 11 (4), pp.464-472. ⟨10.1021/acsmedchemlett.9b00566⟩ Article dans une revue hal-02476867v1
Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment Thomas Adnet,Anne-Claire Groo,Céline Picard,Audrey Davis,Sophie Corvaisieret al. Pharmaceutics, 2020, 12 (3), pp.251. ⟨10.3390/pharmaceutics12030251⟩ Article dans une revue hal-03969997v1
Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes Martina de Pascale,Domenico Iacopetta,Marc Since,Sophie Corvaisier,V. Viéet al. ChemMedChem, 2020, 15 (1), pp.136-154. ⟨10.1002/cmdc.201900542⟩ Article dans une revue hal-02434628v1
8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi Cyril Fersing,Clotilde Boudot,Caroline Castera-Ducros,Émilie Pinault,Sébastien Hutteret al. European Journal of Medicinal Chemistry, 2020, 202, pp.112558. ⟨10.1016/j.ejmech.2020.112558⟩ Article dans une revue hal-02899751v1
Antikinetoplastid SAR study in 3-nitroimidazopyridine series: Identification of a novel non-genotoxic and potent anti-T. b. brucei hit-compound with improved pharmacokinetic properties Cyril Fersing,Clotilde Boudot,Romain Paoli-Lombardo,Nicolas Primas,Emilie Pinaultet al. European Journal of Medicinal Chemistry, 2020, 206, pp.112668. ⟨10.1016/j.ejmech.2020.112668⟩ Article dans une revue hal-02920293v1
Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease François-Xavier Toublet,Cédric Lecoutey,Julien Lalut,Bérénice Hatat,Audrey Daviset al. Molecules, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩ Article dans une revue hal-02399906v1
Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease Caroline Lanthier,Hugo Payan,Irene Liparulo,Bérénice Hatat,Cédric Lecouteyet al. European Journal of Medicinal Chemistry, 2019, 182, pp.111596. ⟨10.1016/j.ejmech.2019.111596⟩ Article dans une revue hal-02399942v1
Microplate assay for lipophilicity determination using intrinsic fluorescence of drugs: Application to a promising anticancer lead, pyridoclax Willy Smeralda,Marc Since,Sophie Corvaisier,Rémi Legay,Anne-Sophie Voisin-Chiretet al. European Journal of Pharmaceutical Sciences, 2019, 131, pp.75-83. ⟨10.1016/j.ejps.2019.02.010⟩ Article dans une revue hal-02168030v1
Nongenotoxic 3-Nitroimidazo[1,2- a ]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity Cyril Fersing,Louise Basmaciyan,Clotilde Boudot,Julien Pedron,Sébastien Hutteret al. ACS Medicinal Chemistry Letters, 2019, 10 (1), pp.34-39. ⟨10.1021/acsmedchemlett.8b00347⟩ Article dans une revue hal-02478935v1
Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment Jean-Pierre Jourdan,Marc Since,Laïla El kihel,Cédric Lecoutey,Sophie Corvaisieret al. ChemMedChem, 2017, 12 (12), pp.913-916. ⟨10.1002/cmdc.201700102⟩ Article dans une revue hal-02043731v1
Comparison of 2 strategies to enhance pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis Anne-Claire Groo,Martina de Pascale,Anne-Sophie Voisin-Chiret,Sophie Corvaisier,Marc Sinceet al. European Journal of Pharmaceutical Sciences, 2017, 97, pp.218-226. ⟨10.1016/j.ejps.2016.11.025⟩ Article dans une revue istex hal-02160866v1
Evaluation of the versatile character of a nanoemulsion formulation Emilie Gué,Marc Since,S. Ropars,R. Herbinet,L. Le Pluartet al. International Journal of Pharmaceutics, 2016, 498 (1-2), pp.49-65. ⟨10.1016/j.ijpharm.2015.12.010⟩ Article dans une revue istex hal-01847973v1
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment Jean-Pierre Jourdan,Marc Since,Laïla El Kihel,Cédric Lecoutey,Sophie Corvaisieret al. European Journal of Medicinal Chemistry, 2016, 114, pp.365-379. ⟨10.1016/j.ejmech.2016.03.023⟩ Article dans une revue hal-02043765v1
Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography Julien Lalut,Benjamin B. Tournier,Thomas Cailly,Cédric Lecoutey,Sophie Corvaisieret al. European Journal of Medicinal Chemistry, 2016, 116, pp.90-101. ⟨10.1016/j.ejmech.2016.03.059⟩ Article dans une revue hal-02011098v1
Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment Cédric Lecoutey,Damien Hedou,Thomas Freret,Patrizia Giannoni,Florence Gavenet al. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩ Article dans une revue hal-01800439v2
Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease. David Genest,Christophe Rochais,Cédric Lecoutey,Jana Sopkova-de Oliveira Santos,Céline Ballandonneet al. MedChemComm, 2013, 4, pp.925-931 Article dans une revue hal-00840942v1
New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: Synthesis and antinociceptive evaluation Marc Since,Thomas Freret,Gerald Nee,Thierry Terme,Patrice Vanelleet al. European Journal of Medicinal Chemistry, 2013, 69, pp.728--734. ⟨10.1016/j.ejmech.2013.08.041⟩ Article dans une revue istex hal-01460473v1
First SNAr reaction using TDAE-initiated carbanions in quinazoline series Marc Since,Omar Khoumeri,Pierre Verhaeghe,Martine Maillard-Boyer,Thierry Termeet al. Tetrahedron Letters, 2011, 52 (29), pp.3810--3813. ⟨10.1016/j.tetlet.2011.05.060⟩ Article dans une revue istex hal-01460328v1
Original TDAE strategy using α-halocarbonyl derivatives Marc Since,Thierry Terme,Patrice Vanelle Tetrahedron, 2009, 65 (31), pp.6128-6134. ⟨10.1016/j.tet.2009.05.036⟩ Article dans une revue istex hal-05577598v1

Poster de conférence (3)

Pharmacokinetic and safety of a novel pleiotropic compound in C57BL/6J mice with potential therapeutic interest in Alzheimer’s disease Caroline Lahogue,Stacy Largilliere,Gérald Nee,Alice Wang,Stéphanie Lagaduet al. FENS 2024, Jun 2024, Vienne, Austria Poster de conférence hal-04632974v1
Introduction to the versatility of biomimetic membranes to characterize modulators of Aβ1-42 fibrillization with potential interest in Alzheimer's disease treatment Willy Smeralda,Marc Since,Michael Boisserie,Sophie Corvaisier,Julien Cardinet al. 32ème Journées Franco-Belges de Chimie Thérapeutique et 26ème Rencontres Internationales des Pharmacochimistes de l'Arc Atlantique, , Jun 2018, Asnelles sur Mer, France. 2018 Poster de conférence hal-01844495v1
Development of a nasal drug delivery composite nanosystem for Alzheimer’s desease treatment Adnet Thomas,Anne-Claire Groo,Loïc Le Pluart,Celine Picard,A. Daviset al. Journée normande de recherche biomédicale, Nov 2017, caen, France Poster de conférence hal-02295929v1

Communication dans un congrès (1)

Evaluation préclinique de nanoémulsions polyvalentes comme vecteurs d’un nouvel inhibiteur de Mcl-1, le Pyridoclax : application au traitement des cancers de l’ovaire (PYRINANO) Aurélie Malzert-Fréon,Anne-Claire Groo,Siham Hedir,Marc Since,Martina de Pascaleet al. 10émes journées scientifiques du cancéropole nord-ouest, May 2017, Deauville, France Communication dans un congrès hal-02295794v1