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Marc Monot



Education 2013 **Ph.D. Microbiology** *Paris 7University Paris, FR* 2009 **Master Bioinformatics** *Paris 7University Paris, FR* 2000 **B.Sc Biochemistry** *Preston University Preston, UK* <a name="OLE_LINK12"></a><a name="OLE_LINK11"></a>Professional Experiences Nomination in 2016 asAssociate Professorof the University of Sherbrooke, Canada. Since 2018 **Head of the Biomics Platform** *Institut Pasteur Paris, FR* 2010-2017 **Permanent Scientist** *Institut Pasteur* *Paris, FR* *Laboratoire Pathogenèse des Batéries Anaérobies headed by Dr. B. Dupuy* 2002-07 **ResearchTechnician** *Institut Pasteur Paris, FR* *Unité de Génétique Moléculaire Bactérienne headed by Dr S. T. Cole* Student Supervision **Ph.D.**Student(2016-2020), **Master**Student (2011-2012), **ResearchTechnician**(2008-2010). Communications **Invited Speaker:** Sherbrooke University, Canada (2015). **Oral presentation**: Core4Life, Barcelone (2019), France Génomique, France (2018), Phage-Sur-Yvette, France (2017), Clostpath 8thPalm Cove, Australia (2013) **Poster presentations:** Clostpath 6thRome, Italie (2009); ICDS Bled, Slovenia (2010); JOBIM Renne, France (2012) and Clostpath 9thFreiburg, Germany (2015) Responsability **Member of the scientific evaluation comittee** (Institut Pasteur 2015-17) **Editorial board member**(Scientific Reports 2017-2019) Scientific production **50 publications**(10 in first or last author including 5 as corresponding author). **H-index** : 28,**citations** : 3237, **HAL**deposit. [;hl=fr&amp;oi=ao](


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The cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile

Emile Auria , Lise Hunault , Patrick England , Marc Monot , Juliana Pipoli da Fonseca
npj Biofilms and Microbiomes, 2023, 9 (1), pp.24. ⟨10.1038/s41522-023-00393-5⟩
Journal articles pasteur-04099827v1
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Capturing SARS-CoV-2 from patient samples with low viral abundance: a comparative analysis

Juliana Pipoli da Fonseca , Etienne Kornobis , Elodie Turc , Vincent Enouf , Laure Lemée
Scientific Reports, 2022, 12 (1), pp.19274. ⟨10.1038/s41598-022-23422-3⟩
Journal articles pasteur-03884256v1
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Core-, pan- and accessory genome analyses of Clostridium neonatale: insights into genetic diversity

Victoria Mesa , Marc Monot , Laurent Ferraris , Michel Popoff , Christelle Mazuet
Microbial Genomics, 2022, 8 (5), pp.000813. ⟨10.1099/mgen.0.000813⟩
Journal articles pasteur-03711097v1
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High-throughput identification of viral termini and packaging mechanisms in virome datasets using PhageTermVirome

Julian R. Garneau , Véronique Legrand , Martial Marbouty , Maximilian O. Press , Dean R. Vik
Scientific Reports, 2021, 11 (1), pp.18319. ⟨10.1038/s41598-021-97867-3⟩
Journal articles pasteur-03369740v1

How Did Institut Pasteur’s NGS Core Facility, Biomics, Manage the Coronavirus Disease 2019 Crisis?

Imen Najjar , Laurence Motreff , Laurence Ma , Laure Lemée , Valérie Briolat
Journal of Biomolecular Techniques, 2021, 32 (2), pp.jbt.21-3202-004. ⟨10.7171/jbt.21-3202-004⟩
Journal articles pasteur-03371253v1
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Transcriptomic and Phenotypic Analysis of a spoIIE Mutant in Clostridium beijerinckii

Mamou Diallo , Nicolas Kint , Marc Monot , Florent Collas , Isabelle Martin-Verstraete
Frontiers in Microbiology, 2020, 11, pp.556064. ⟨10.3389/fmicb.2020.556064⟩
Journal articles pasteur-03036263v1
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Genome-Wide Transcription Start Site Mapping and Promoter Assignments to a Sigma Factor in the Human Enteropathogen Clostridioides difficile

Olga Soutourina , Thomas Dubois , Marc Monot , Pavel Shelyakin , Laure Saujet
Frontiers in Microbiology, 2020, 11, pp.1939. ⟨10.3389/fmicb.2020.01939⟩
Journal articles hal-02921326v1

Role of the global regulator Rex in control of NAD + ‐regeneration in Clostridioides (Clostridium) difficile

Laurent Bouillaut , Thomas Dubois , Michael Francis , Nadine Daou , Marc Monot
Molecular Microbiology, 2019, 111 (6), pp.1671-1688. ⟨10.1111/mmi.14245⟩
Journal articles pasteur-02438283v1
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A microbiota-generated bile salt induces biofilm formation in Clostridium difficile

Thomas Dubois , Yannick D. N. Tremblay , Audrey Hamiot , Isabelle Martin-Verstraete , Julien Deschamps
npj Biofilms and Microbiomes, 2019, 5 (1), ⟨10.1038/s41522-019-0087-4⟩
Journal articles hal-02154613v1
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Clostridium difficile Biofilm: Remodeling Metabolism and Cell Surface to Build a Sparse and Heterogeneously Aggregated Architecture

Isabelle Poquet , Laure Saujet , Alexis Canette , Marc Monot , Jovanna Mihajlovic
Frontiers in Microbiology, 2018, 9, pp.2084. ⟨10.3389/fmicb.2018.02084⟩
Journal articles pasteur-02015642v1

High Prevalence and Genetic Diversity of Large phiCD211 (phiCDIF1296T)-Like Prophages in Clostridioides difficile.

Julian R. Garneau , Ognjen Sekulovic , Bruno Dupuy , Olga Soutourina , Marc Monot
Applied and Environmental Microbiology, 2018, 84 (3), pp.e02164-17. ⟨10.1128/AEM.02164-17⟩
Journal articles hal-02178884v1
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Discovery of new type I toxin–antitoxin systems adjacent to CRISPR arrays in Clostridium difficile

Anna Maikova , Johann Peltier , Pierre Boudry , Eliane Hajnsdorf , Nicolas Kint
Nucleic Acids Research, 2018, 46 (9), pp.4733-4751. ⟨10.1093/nar/gky124⟩
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Clostridium difficile forms variable biofilms on abiotic surface

Véronique Pantaleon , Marc Monot , Catherine Eckert , Sandra Hoys , Anne Collignon
Anaerobe, 2018, 53, pp.34-37. ⟨10.1016/j.anaerobe.2018.05.006⟩
Journal articles pasteur-02549240v1
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Comparative transcriptomics analyses reveal the conservation of an ancestral infectious strategy in two bacteriophage genera.

Bob G Blasdel , Anne Chevallereau , Marc Monot , Rob Lavigne , Laurent Debarbieux
ISME Journal, 2017, Advance online publication, ⟨10.1038/ismej.2017.63⟩
Journal articles pasteur-01538822v1
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Effect of tcdR Mutation on Sporulation in the Epidemic Clostridium difficile Strain R20291

Brintha Girinathan , Marc Monot , Daniel Boyle , Kathleen N. Mcallister , Joseph A. Sorg
MSphere, 2017, 2 (1), pp.00383-16. ⟨10.1128/mSphere.00383-16⟩
Journal articles pasteur-01613368v1
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PhageTerm: a tool for fast and accurate determination of phage termini and packaging mechanism using next-generation sequencing data

Julian Garneau , Florence Depardieu , Louis-Charles Fortier , David Bikard , Marc Monot
Scientific Reports, 2017, 7 (1), pp.8292. ⟨10.1038/s41598-017-07910-5⟩
Journal articles pasteur-01613364v1

The alternative sigma factor σ B plays a crucial role in adaptive strategies of Clostridium difficile during gut infection

Nicolas Kint , Claire Janoir , Marc Monot , Sandra Hoys , Olga Soutourina
Environmental Microbiology, 2017, Special Issue on Pathogen and Antibiotic Resistance Ecology 19 (5), pp.1933 - 1958. ⟨10.1111/1462-2920.13696⟩
Journal articles pasteur-01613370v1
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Next-Generation "-omics" Approaches Reveal a Massive Alteration of Host RNA Metabolism during Bacteriophage Infection of Pseudomonas aeruginosa.

Anne Chevallereau , Bob G Blasdel , Jeroen de Smet , Marc Monot , Michael Zimmermann
PLoS Genetics, 2016, 12 (7), pp.e1006134. ⟨10.1371/journal.pgen.1006134⟩
Journal articles pasteur-01350678v1
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Deciphering Adaptation Strategies of the Epidemic Clostridium difficile 027 Strain during Infection through In Vivo Transcriptional Analysis

Imad Kansau , Amira Barketi-Klai , Marc Monot , Sandra Hoys , Bruno Dupuy
PLoS ONE, 2016, 11 (6), pp.e0158204. ⟨10.1371/journal.pone.0158204⟩
Journal articles pasteur-01370713v1
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Cpe1786/IscR of Clostridium perfringens represses expression of genes involved in Fe-S cluster biogenesis.

Gaelle André , Elise Haudecoeur , Emmanuelle Courtois , Marc Monot , Bruno Dupuy
Research in Microbiology, 2016, ⟨10.1016/j.resmic.2016.03.002⟩
Journal articles pasteur-01370878v1
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Control of Clostridium difficile Physiopathology in Response to Cysteine Availability.

Thomas Dubois , Marie Dancer-Thibonnier , Marc Monot , Audrey Hamiot , Laurent Bouillaut
Infection and Immunity, 2016, 84 (8), pp.2389-405. ⟨10.1128/IAI.00121-16⟩
Journal articles pasteur-01370880v1
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What's a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives.

Mark M Collery , Sarah A Kuehne , Shonna M Mcbride , Michelle L Kelly , Marc Monot
Journal articles pasteur-01370882v1
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Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus

Marc Monot , Catherine Eckert , Astrid Lemire , Audrey Hamiot , Thomas Dubois
Scientific Reports, 2015, 5, pp.15023. ⟨10.1038/srep15023⟩
Journal articles hal-01271725v1

Integration of erm (B)-containing elements through large chromosome fragment exchange in Clostridium difficile

François Wasels , Patrizia Spigaglia , Fabrizio Barbanti , Marc Monot , Laura Villa
Mobile Genetic Elements, 2015, 5 (1), pp.12-16. ⟨10.1080/2159256X.2015.1006111⟩
Journal articles pasteur-01370722v1
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Capsules, Toxins and AtxA as Virulence Factors of Emerging Bacillus cereus Biovar anthracis

Christophe Brézillon , Michel Haustant , Susann Dupke , Jean-Philippe Corre , Angelika Lander
PLoS Neglected Tropical Diseases, 2015, 9 (4), pp.e0003455. ⟨10.1371/journal.pntd.0003455⟩
Journal articles pasteur-01370745v1
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Repressor activity of the RpoS/σS-dependent RNA polymerase requires DNA binding

Corinne Levi-Meyrueis , Véronique Monteil , Odile Sismeiro , Marie-Agnès Dillies , Annie Kolb
Nucleic Acids Research, 2015, 43 (3), pp.1456 - 1468. ⟨10.1093/nar/gku1379⟩
Journal articles pasteur-01370752v1
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Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile

Pierre Boudry , Ekaterina Semenova , Marc Monot , Kirill A. Datsenko , Anna Lopatina
mBio, 2015, 6 (5), pp.e01112-15. ⟨10.1128/mBio.01112-15⟩
Journal articles pasteur-01370739v1
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Inter- and intraspecies transfer of a Clostridium difficile conjugative transposon conferring resistance to MLSB.

François Wasels , Marc Monot , Patrizia Spigaglia , Fabrizio Barbanti , Laurence Ma
Microbial Drug Resistance, 2014, 20 (6), pp.555-60. ⟨10.1089/mdr.2014.0015⟩
Journal articles pasteur-01370763v1
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Expanding the RpoS/σS-network by RNA sequencing and identification of σS-controlled small RNAs in Salmonella.

Corinne Lévi-Meyrueis , Véronique Monteil , Odile Sismeiro , Marie-Agnès Dillies , Marc Monot
PLoS ONE, 2014, 9 (5), pp.e96918. ⟨10.1371/journal.pone.0096918⟩
Journal articles pasteur-01370762v1

Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.

Ines Moura , Marc Monot , Chiara Tani , Patrizia Spigaglia , Fabrizio Barbanti
Antimicrobial Agents and Chemotherapy, 2014, 58 (8), pp.4957-60. ⟨10.1128/AAC.02350-14⟩
Journal articles pasteur-01370760v1
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COV2HTML: A Visualization and Analysis Tool of Bacterial Next Generation Sequencing (NGS) Data for Postgenomics Life Scientists

Marc Monot , Mickael Orgeur , Emilie Camiade , Clément Brehier , Bruno Dupuy
OMICS, 2014, 18 (3), pp.184-195. ⟨10.1089/omi.2013.0119⟩
Journal articles pasteur-01370754v1
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The flagellin FliC of Clostridium difficile is responsible for pleiotropic gene regulation during in vivo infection.

Amira Barketi-Klai , Marc Monot , Sandra Hoys , Sylvie Lambert-Bordes , Sarah A Kuehne
PLoS ONE, 2014, 9 (5), pp.e96876. ⟨10.1371/journal.pone.0096876⟩
Journal articles pasteur-01370758v1
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Sequence similarity of Clostridium difficile strains by analysis of conserved genes and genome content is reflected by their ribotype affiliation.

Hedwig Kurka , Armin Ehrenreich , Wolfgang Ludwig , Marc Monot , Maja Rupnik
PLoS ONE, 2014, 9 (1), pp.e86535. ⟨10.1371/journal.pone.0086535⟩
Journal articles pasteur-01370765v1

Pleiotropic Role of the RNA Chaperone Protein Hfq in the Human Pathogen Clostridium difficile

Pierre Boudry , C. Gracia , M. Monot , J. Caillet , L. Saujet
Journal of Bacteriology, 2014, 196 (18), pp.3234-3248. ⟨10.1128/JB.01923-14⟩
Journal articles pasteur-02440841v1
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Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile.

Olga A Soutourina , Marc Monot , Pierre Boudry , Laure Saujet , Christophe Pichon
PLoS Genetics, 2013, 9 (5), pp.e1003493. ⟨10.1371/journal.pgen.1003493⟩
Journal articles pasteur-01370770v1
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Characterization of the SigD regulon of C. difficile and its positive control of toxin production through the regulation of tcdR.

Imane El Meouche , Johann Peltier , Marc Monot , Olga Soutourina , Martine Pestel-Caron
PLoS ONE, 2013, 8 (12), pp.e83748. ⟨10.1371/journal.pone.0083748⟩
Journal articles pasteur-01370779v1
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The spore differentiation pathway in the enteric pathogen Clostridium difficile.

Fátima C Pereira , Laure Saujet , Ana R Tomé , Mónica Serrano , Marc Monot
PLoS Genetics, 2013, 9 (10), pp.e1003782. ⟨10.1371/journal.pgen.1003782⟩
Journal articles pasteur-01370787v1
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Genome-Wide Analysis of Cell Type-Specific Gene Transcription during Spore Formation in Clostridium difficile

Laure Saujet , Fátima C Pereira , Monica Serrano , Olga Soutourina , Marc Monot
PLoS Genetics, 2013, 9 (10), pp.e1003756. ⟨10.1371/journal.pgen.1003756⟩
Journal articles pasteur-01370780v1
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Adaptive Strategies and Pathogenesis of Clostridium difficile from In Vivo Transcriptomics

Claire Janoir , Cécile Denève , Sylvie Bouttier , Frédéric Barbut , Sandra Hoys
Infection and Immunity, 2013, 81 (10), pp.3757-3769. ⟨10.1128/IAI.00515-13⟩
Journal articles hal-04152660v1
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Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile.

Ana Antunes , Emilie Camiade , Marc Monot , Emmanuelle Courtois , Frédéric Barbut
Nucleic Acids Research, 2012, 40 (21), pp.10701-18. ⟨10.1093/nar/gks864⟩
Journal articles pasteur-01370790v1

The key sigma factor of transition phase, SigH, controls sporulation, metabolism, and virulence factor expression in Clostridium difficile.

Laure Saujet , Marc Monot , Bruno Dupuy , Olga Soutourina , Isabelle Martin-Verstraete
Journal of Bacteriology, 2011, 193 (13), pp.3186-96. ⟨10.1128/JB.00272-11⟩
Journal articles pasteur-01370840v1

Molecular drug susceptibility testing and genotyping of Mycobacterium leprae strains from South America.

Pushpendra Singh , Philippe Busso , Alberto Paniz-Mondolfi , Nacarid Aranzazu , Marc Monot
Antimicrobial Agents and Chemotherapy, 2011, 55 (6), pp.2971-3. ⟨10.1128/AAC.00201-11⟩
Journal articles pasteur-01370845v1
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Rapid diagnosis of Clostridium difficile infection by multiplex real-time PCR.

Frédéric Barbut , Marc Monot , Antoine Rousseau , Sébastien Cavelot , Tabassome Simon
European Journal of Clinical Microbiology and Infectious Diseases, 2011, 30 (10), pp.1279-85. ⟨10.1007/s10096-011-1224-z⟩
Journal articles pasteur-01370849v1
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Reannotation of the genome sequence of Clostridium difficile strain 630.

Marc Monot , Caroline Boursaux-Eude , Marie Thibonnier , David Vallenet , Ivan Moszer
Journal of Medical Microbiology, 2011, 60 (8), pp.1193-9. ⟨10.1099/jmm.0.030452-0⟩
Journal articles pasteur-01370838v1

Effect of serial subculturing on the genetic composition and cytotoxic activity of Mycobacterium tuberculosis.

C A Molina-Torres , J Castro-Garza , J Ocampo-Candiani , M Monot , S T Cole
Journal of Medical Microbiology, 2010, 59 (4), pp.384-91. ⟨10.1099/jmm.0.015966-0⟩
Journal articles pasteur-01370851v1

Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events.

Sheerazed Boulkroun , Laure Guenin-Macé , Maria-Isabel Thoulouze , Marc Monot , Anaïs Merckx
Journal of Immunology, 2010, 184 (3), pp.1436-44. ⟨10.4049/jimmunol.0902854⟩
Journal articles pasteur-00594632v1
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Global regulation of gene expression in response to cysteine availability in Clostridium perfringens.

Gaelle André , Elise Haudecoeur , Marc Monot , Kaori Ohtani , Tohru Shimizu
BMC Microbiology, 2010, 10 (1), pp.234. ⟨10.1186/1471-2180-10-234⟩
Journal articles pasteur-00670625v1
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Mycobacterium leprae genotype amplified from an archaeological case of lepromatous leprosy in Central Asia

G. Michael Taylor , Soren Blau , Simon Mays , Marc Monot , Oona Y.-C. Lee
Journal of Archaeological Science, 2009, 36 (10), pp.2408-2414. ⟨10.1016/j.jas.2009.06.026⟩
Journal articles pasteur-01370863v1
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Comparative genomic and phylogeographic analysis of Mycobacterium leprae.

Marc Monot , Nadine Honoré , Thierry Garnier , Nora Zidane , Diana Sherafi
Nature Genetics, 2009, 41 (12), pp.1282-9. ⟨10.1038/ng.477⟩
Journal articles pasteur-01370857v1

Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?

Marc Monot , Nadine Honoré , Charlotte Balière , Baohong Ji , Samba Sow
Journal of Clinical Microbiology, 2008, 46 (7), pp.2291-7. ⟨10.1128/JCM.00239-08⟩
Journal articles pasteur-01370869v1
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Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP.

Wafa Frigui , Daria Bottai , Laleh Majlessi , Marc Monot , Emmanuelle Josselin
PLoS Pathogens, 2008, 4 (2), pp.e33. ⟨10.1371/journal.ppat.0040033⟩
Journal articles pasteur-01370872v1
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Antigen discovery: a postgenomic approach to leprosy diagnosis.

Romulo Aráoz , Nadine Honoré , Sungae Cho , Jong-Pill Kim , Sang-Nae Cho
Infection and Immunity, 2006, 74 (1), pp.175-82. ⟨10.1128/IAI.74.1.175-182.2006⟩
Journal articles pasteur-00204119v1
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Towards an immunodiagnostic test for leprosy.

Romulo Aráoz , Nadine Honoré , Sayera Banu , Caroline Demangel , Yakouba Cissoko
Microbes and Infection, 2006, 8 (8), pp.2270-6. ⟨10.1016/j.micinf.2006.04.002⟩
Journal articles pasteur-01370874v1
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On the origin of leprosy.

Marc Monot , Nadine Honoré , Thierry Garnier , Romulo Araoz , Jean-Yves Coppée
Science, 2005, 308 (5724), pp.1040-2. ⟨10.1126/science/1109759⟩
Journal articles pasteur-00204117v1