Accéder directement au contenu

martin villalba

58
Documents

Publications

Image document

A novel Fc-engineered cathepsin D-targeting antibody enhances ADCC, triggers tumor-infiltrating NK cell recruitment, and improves treatment with paclitaxel and enzalutamide in triple-negative breast cancer

Pénélope Desroys Du Roure , Laurie Lajoie , Aude Mallavialle , Lindsay Alcaraz , Hanane Mansouri
Journal for Immunotherapy of Cancer, 2024, 12 (1), pp.e007135. ⟨10.1136/jitc-2023-007135⟩
Article dans une revue hal-04459385v1
Image document

10th antibody industrial symposium: new developments in antibody and adoptive cell therapies

Ana Antunes , Luis Álvarez-Vallina , Federico Bertoglio , Nicolas Bouquin , Stéphanie Cornen
mAbs, 2023, 15 (1), pp.2211692. ⟨10.1080/19420862.2023.2211692⟩
Article dans une revue hal-04121982v1
Image document

Direct Cell Death Induced by CD20 Monoclonal Antibodies on B Cell Lymphoma Cells Revealed by New Protocols of Analysis

Michael Constantinides , Alexis Fayd’herbe de Maudave , Marie Potier-Cartereau , Mauricio Campos-Mora , Guillaume Cartron
Cancers, 2023, 15 (4), pp.1109. ⟨10.3390/cancers15041109⟩
Article dans une revue hal-04038932v1
Image document

Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody

François Noverraz , Baptiste Robin , Solène Passemard , Bénédicte Fauvel , Jessy Presumey
International Journal of Pharmaceutics, 2023, 630, pp.122463. ⟨10.1016/j.ijpharm.2022.122463⟩
Article dans une revue hal-03935985v1
Image document

NK cells in peripheral blood carry trogocytosed tumor antigens from solid cancer cells

Mauricio Campos-Mora , William Jacot , Geneviève Garcin , Marie-Lise Depondt , Michael Constantinides
Frontiers in Immunology, 2023, 14, pp.1199594. ⟨10.3389/fimmu.2023.1199594⟩
Article dans une revue hal-04252345v1
Image document

Dynamic Changes in miRNA Expression during the Generation of Expanded and Activated NK Cells

Chantal Reina-Ortiz , Mª Pilar Mozas , David Ovelleiro , Fei Gao , Martín Villalba
International Journal of Molecular Sciences, 2023, 24 (17), pp.13556. ⟨10.3390/ijms241713556⟩
Article dans une revue hal-04252386v1
Image document

Cytokines impact natural killer cell phenotype and functionality against glioblastoma in vitro

Minna Sivonen , Katja Sirviö , Sara Wojciechowski , Anssi Kailaanmäki , Satu Kaipainen
Frontiers in Immunology, 2023, 14, pp.1227064. ⟨10.3389/fimmu.2023.1227064⟩
Article dans une revue hal-04252360v1
Image document

g-NK cells from umbilical cord blood are phenotypically and functionally different than g-NK cells from peripheral blood

Fei Gao , Mauricio Campos-Mora , Michael Constantinides , Loïs Coenon , Caroline Multrier
OncoImmunology, 2023, 12 (1), pp.2283353. ⟨10.1080/2162402x.2023.2283353⟩
Article dans une revue hal-04301529v1
Image document

NK Cells Acquire CCR5 and CXCR4 by Trogocytosis in People Living with HIV-1

Dang-Nghiem Vo , Nicolas Leventoux , Mauricio Campos-Mora , Sandrine Gimenez , Pierre Corbeau
Vaccines, 2022, 10 (5), pp.688. ⟨10.3390/vaccines10050688⟩
Article dans une revue hal-03757390v1
Image document

Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1)

Nerea Allende-Vega , Joaquin Marco Brualla , Paolo Falvo , Catherine Alexia , Michael Constantinides
Scientific Reports, 2022, 12 (1), pp.1341. ⟨10.1038/s41598-022-05470-x⟩
Article dans une revue hal-03564112v1
Image document

Glucose Starvation or Pyruvate Dehydrogenase Activation Induce a Broad, ERK5-Mediated, Metabolic Remodeling Leading to Fatty Acid Oxidation

Abrar Ul Haq Khan , Hamideh Salehi , Catherine Alexia , Jose M Valdivielso , Milica Bozic
Cells, 2022, 11 (9), pp.1392. ⟨10.3390/cells11091392⟩
Article dans une revue hal-03757316v1
Image document

Intra-articular delivery of full-length antibodies through the use of an in situ forming depot

Alexis Fayd'Herbe de Maudave , Wilhem Leconet , Karine Toupet , Michael Constantinides , Guillaume Bossis
Journal of Controlled Release, 2022, 341, pp.578-590. ⟨10.1016/j.jconrel.2021.12.010⟩
Article dans une revue hal-03563900v1
Image document

From CD16a Biology to Antibody-Dependent Cell-Mediated Cytotoxicity Improvement

Loïs Coënon , Martin Villalba
Frontiers in Immunology, 2022, 13, pp.913215. ⟨10.3389/fimmu.2022.913215⟩
Article dans une revue hal-03757448v1
Image document

The metabolism of cells regulates their sensitivity to NK cells depending on p53 status

Sana Belkahla , Joaquin Marco Brualla , Alexis Fayd’herbe de Maudave , Paolo Falvo , Nerea Allende-Vega
Scientific Reports, 2022, 12 (1), pp.3234. ⟨10.1038/s41598-022-07281-6⟩
Article dans une revue hal-03595038v1
Image document

Harnessing the Potential of NK Cell-Based Immunotherapies against Multiple Myeloma

Chantal Reina-Ortiz , David Giraldos , Gemma Azaceta , Luis Palomera , Isabel Marzo
Cells, 2022, 11 (3), pp.392. ⟨10.3390/cells11030392⟩
Article dans une revue hal-03585338v1
Image document

Expanded NK cells from umbilical cord blood and adult peripheral blood combined with daratumumab are effective against tumor cells from multiple myeloma patients

Chantal Reina-Ortiz , Michael Constantinides , Alexis Fayd-Herbe-De-Maudave , Jessy Présumey , Javier Hernandez
OncoImmunology, 2021, 10 (1), pp.1853314. ⟨10.1080/2162402X.2020.1853314⟩
Article dans une revue hal-03163825v1
Image document

Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis

Karim Mrouj , Nuria Andrés-Sánchez , Geronimo Dubra , Priyanka Singh , Michal Sobecki
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (10), pp.e2026507118. ⟨10.1073/pnas.2026507118⟩
Article dans une revue hal-03364397v1
Image document

Dissecting the NK cell population in hematological cancers confirms the presence of tumor cells and their impact on NK population function

Dang-Nghiem Vo , Michael Constantinides , Nerea Allende-Vega , Catherine Alexia , Guillaume Cartron
Vaccines, 2020, 8 (4), pp.727. ⟨10.3390/vaccines8040727⟩
Article dans une revue hal-03031877v1
Image document

Editorial: The Natural Killer Cell Interactome in the Tumor Microenvironment: Basic Concepts and Clinical Application

Alberto Anel , Julián Pardo , Martin Villalba
Frontiers in Immunology, 2020, 11, pp.872. ⟨10.3389/fimmu.2020.00872⟩
Article dans une revue hal-02924407v1
Image document

Naturally improving the natural cytotoxicity of natural killer (NK) cells

Martin Villalba , Catherine Alexia , Anais Bellin-Robert , Alexis Fayd'Herbe de Maudave , Delphine Gitenay
Frontiers in Immunology, 2020, 10, pp.3026. ⟨10.3389/fimmu.2019.03026⟩
Article dans une revue inserm-02711666v1
Image document

Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance

Tania Calvo , Chantal Reina‑ortiz , David Giraldos , María Gascón , Daniel Woods
Scientific Reports, 2020, 10 (1), pp.19398. ⟨10.1038/s41598-020-76051-z⟩
Article dans une revue hal-03010044v1
Image document

Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells

Martin Villalba , Nerea Allende-Vega
Scientific Reports, 2019, 9 (1), pp.5637. ⟨10.1038/s41598-019-42220-y⟩
Article dans une revue inserm-02334210v1
Image document

Mutations in the ND2 Subunit of Mitochondrial Complex I Are Sufficient to Confer Increased Tumorigenic and Metastatic Potential to Cancer Cells.

Joaquín Marco-Brualla , Sameer Al-Wasaby , Ruth Soler , Eduardo Romanos , Blanca Conde
Cancers, 2019, 11 (7), pp.E1027. ⟨10.3390/cancers11071027⟩
Article dans une revue inserm-02334214v1
Image document

Polyoxidonium® Activates Cytotoxic Lymphocyte Responses Through Dendritic Cell Maturation: Clinical Effects in Breast Cancer

Catherine Alexia , Maïlys Cren , Pascale Louis-Plence , Dang-Nghiem Vo , Yasamine El Ahmadi
Frontiers in Immunology, 2019, 10, pp.2693. ⟨10.3389/fimmu.2019.02693⟩
Article dans une revue hal-02414398v1
Image document

Mitochondrial Complex I activity signals antioxidant response through ERK5

Abrar Ul Haq Khan , Nerea Allende-Vega , Delphine Gitenay , Johan Garaude , Dang-Nghiem Vo
Scientific Reports, 2018, 8 (1), pp.7420. ⟨10.1038/s41598-018-23884-4⟩
Article dans une revue hal-01835615v1

NK cell activation and recovery of NK cell subsets in lymphoma patients after obinutuzumab and lenalidomide treatment

Dang-Nghiem Vo , Catherine Alexia , Nerea Allende-Vega , Franck Morschhauser , Roch Houot
OncoImmunology, 2018, 7 (4), pp.e1409322. ⟨10.1080/2162402X.2017.1409322⟩
Article dans une revue hal-01780378v1
Image document

Changes in metabolism affect expression of ABC transporters through ERK5 and depending on p53 status

Sana Belkahla , Abrar Ul Haq Khan , Delphine Gitenay , Catherine Alexia , Claire Gondeau
Oncotarget, 2018, 9 (1), pp.1114--1129. ⟨10.18632/oncotarget.23305⟩
Article dans une revue hal-02345948v1
Image document

Expansion of allogeneic NK cells with efficient antibody-dependent cell cytotoxicity against multiple tumors

Diego Sanchez , Nerea Allende-Vega , Stefania Orecchioni , Giovanna Talarico , Amélie Cornillon
Theranostics, 2018, 8 (14), pp.3856-3869. ⟨10.7150/thno.25149⟩
Article dans une revue inserm-02351977v1
Image document

The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

Abrar Ul Haq Khan , Nerea Allende-Vega , Delphine Gitenay , Sabine Gerbal-Chaloin , Claire Gondeau
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-10339-5⟩
Article dans une revue hal-01835605v1
Image document

Activated Allogeneic NK Cells Preferentially Kill Poor Prognosis B-Cell Chronic Lymphocytic Leukemia Cells

Diego Sánchez-Martínez , Pilar Lanuza , Natalia Gómez , Aura Muntasell , Elisa Cisneros
Frontiers in Immunology, 2016, 7, pp.454. ⟨10.3389/fimmu.2016.00454⟩
Article dans une revue hal-01835596v1
Image document

Human Leukemic Cells performing Oxidative Phosphorylation (OXPHOS) Generate an Antioxidant Response Independently of Reactive Oxygen species (ROS) Production

Abrar Ul Haq Khan , Moeez G. Rathore , Nerea Allende-Vega , Dang-Nghiem Vo , Sana Belkhala
EBioMedicine, 2016, 3, pp.43 - 53. ⟨10.1016/j.ebiom.2015.11.045⟩
Article dans une revue hal-01877446v1
Image document

CD45 Isoform Profile Identifies Natural Killer (NK) Subsets with Differential Activity

Ewelina Krzywinska , Amélie Cornillon , Nerea Allende-Vega , Dang-Nghiem Vo , Céline René
PLoS ONE, 2016, 11 (4), pp.e0150434. ⟨10.1371/journal.pone.0150434⟩
Article dans une revue inserm-01867110v1
Image document

Identification of Anti-tumor Cells Carrying Natural Killer (NK) Cell Antigens in Patients With Hematological Cancers

Ewelina Krzywinska , Nerea Allende-Vega , Amélie Cornillon , Dang-Nghiem Vo , Laure Cayrefourcq
EBioMedicine, 2015, 2 (10), pp.1364 - 1376. ⟨10.1016/j.ebiom.2015.08.021⟩
Article dans une revue inserm-01867114v1
Image document

Human NK cells activated by EBV + lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells

Martin Sanchez-Martinez , Gemma Azaceta , Aura Muntasell , Nacho Aguiló , David Nuñez
OncoImmunology, 2015, 4 (3), pp.e991613. ⟨10.4161/2162402X.2014.991613⟩
Article dans une revue hal-01835574v1
Image document

The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism

Nerea Allende-Vega , Ewelina Krzywinska , Stefania Orecchioni , Nuria Lopez-Royuela , Francesca Reggiani
Oncotarget, 2015, 6 (22), pp.19228-45. ⟨10.18632/oncotarget.4653⟩
Article dans une revue inserm-01868552v2

5′ and 3′ untranslated regions contribute to the differential expression of specific HLA-A alleles

Céline René , Claire Lozano , Martin Villalba , Jean-François Eliaou
European Journal of Immunology, 2015, 45 (12), pp.3454 - 3463. ⟨10.1002/eji.201545927⟩
Article dans une revue hal-01835556v1
Image document

MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells

Elena Catalán , Seyma Charni , Paula Jaime , Juan Ignacio Aguilo , José Antonio Enríquez
OncoImmunology, 2015, 4 (1), ⟨10.4161/2162402X.2014.985924⟩
Article dans une revue hal-01835539v1
Image document

Extracellular-signal-regulated kinase 5 modulates the antioxidant response by transcriptionally controlling Sirtuin 1 expression in leukemic cells

Nuria Lopez-Royuela , Moeez G. Rathore , Nerea Allende-Vega , Jean-Sébastien Annicotte , Lluis Fajas
International Journal of Biochemistry and Cell Biology, 2014, 53, pp.253 - 261. ⟨10.1016/j.biocel.2014.05.026⟩
Article dans une revue inserm-01867017v1
Image document

Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan

Gauthier Bouche , Nicolas André , Shripad Banavali , Frank Berthold , Alfredo Berruti
Ecancer medical science/Ecancermedicalscience - http://www-ncbi-nlm-nih-gov.gate2.inist.fr/pmc/journals/899/ - http://www.ecancer.org/ecms, 2014, 8, pp.463. ⟨10.3332/ecancer.2014.463⟩
Article dans une revue inserm-01867014v1
Image document

IFNα signaling through PKC-θ is essential for antitumor NK cell function

Natalia R. Comet , Juan Ignacio Aguilo , Moeez G. Rathoré , Elena Catalán , Johan Garaude
OncoImmunology, 2014, 3 (8), pp.e948705. ⟨10.4161/21624011.2014.948705⟩
Article dans une revue hal-03108492v1
Image document

All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity

Diego Sánchez-Martínez , Ewelina Krzywinska , Moeez G. Rathore , Anne Saumet , Amélie Cornillon
International Journal of Biochemistry and Cell Biology, 2014, 49, pp.42 - 52. ⟨10.1016/j.biocel.2014.01.003⟩
Article dans une revue inserm-01867016v1
Image document

Chemical Metabolic Inhibitors For The Treatment Of Blood-Borne Cancers.

Martin Villalba , Nuria Lopez-Royuela , Ewelina Krzywinska , Moeez G. Rathore , Robert A. Hipskind
Current Medicinal Chemistry Anticancer Agents, 2014, 14 (2), pp.223-32. ⟨10.2174/18715206113136660374⟩
Article dans une revue inserm-01867009v2
Image document

Controlled Epstein-Barr virus reactivation after allogeneic transplantation is associated with improved survival

Sophie Auger , Mattea Orsini , Patrice Céballos , Nathalie Fegueux , Tarik Kanouni
European Journal of Haematology, 2014, 92 (5), pp.421 - 428. ⟨10.1111/ejh.12260⟩
Article dans une revue inserm-01867012v1

MicroRNAs: new candidates for the regulation of the human cumulus–oocyte complex

Diego Sánchez-Martínez , Ewelina Krzywinska , Moeez G. Rathore , Anne Saumet , Amélie Cornillon
Human Reproduction, 2013, 28 (11), pp.3038-3049. ⟨10.1093/humrep/det321⟩
Article dans une revue hal-02106446v1
Image document

From tumor cell metabolism to tumor immune escape.

Martin Villalba , Moeez G. Rathore , Nuria Lopez-Royuela , Ewelina Krzywinska , Johan Garaude
International Journal of Biochemistry and Cell Biology, 2013, 45 (1), pp.106-13. ⟨10.1016/j.biocel.2012.04.024⟩
Article dans une revue inserm-00726717v1
Image document

The protooncogene Vav1 regulates murine leukemia virus-induced T-cell leukemogenesis.

Sandra Kaminski , Oumeya Adjali , Chantal Jacquet , Johan Garaude , Anne Keriel
OncoImmunology, 2012, 1 (5), pp.600-608. ⟨10.4161/onci.20225⟩
Article dans une revue inserm-00726759v1
Image document

Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity.

Alberto Anel , Juan I. Aguiló , Elena Catalán , Johan Garaude , Moeez G. Rathore
Frontiers in Immunology, 2012, 3, pp.187. ⟨10.3389/fimmu.2012.00187⟩
Article dans une revue inserm-00726668v1
Image document

The NF-κB member p65 controls glutamine metabolism through miR-23a.

Moeez G. Rathore , Anne Saumet , Jean-François Rossi , Carine de Bettignies , Denis Tempé
International Journal of Biochemistry and Cell Biology, 2012, 44 (9), pp.1448-56. ⟨10.1016/j.biocel.2012.05.011⟩
Article dans une revue inserm-00726691v1

ERK5 Knockdown generates mouse leukemia cells with low MHC class i levels that activate NK cells and block tumorigenesis.

Seyma Charni , Juan Ignacio Aguilo , Johan Garaude , Geoffroy de Bettignies , Chantal Jacquet
Journal of Immunology, 2009, 182 (6), pp.3398-405. ⟨10.4049/jimmunol.0803006⟩
Article dans une revue hal-00368654v1

Protein kinase C-theta is required for NK cell activation and in vivo control of tumor progression

J. I. Aguilo , J. Garaude , Juan Carlos Pardo , Martin Villalba , A. Anel
Journal of Immunology, 2009, 182 (4), pp.1972--81. ⟨10.4049/jimmunol.0801820⟩
Article dans une revue hal-02194087v1
Image document

miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice.

Cyrielle Clapé , Vanessa Fritz , Corinne Henriquet , Florence Apparailly , Pedro Luis Fernandez
PLoS ONE, 2009, 4 (10), pp.e7542. ⟨10.1371/journal.pone.0007542⟩
Article dans une revue inserm-00431462v1

The immune escape durin tumorigenesis: its reversibility and its clinical application

S. Charni , M. G. Rathore , Martin Villalba
Bulletin du Cancer, 2009, 96, pp.S31--S31
Article dans une revue hal-02194093v1

ERK5 activates NF-kappaB in leukemic T cells and is essential for their growth in vivo

J. Garaude , S. Cherni , S. Kaminski , E. Delepine , C. Chable-Bessia
Journal of Immunology, 2006, 177 (11), pp.7607-7617. ⟨10.4049/jimmunol.177.11.7607⟩
Article dans une revue hal-02262459v1

The role of ERK5 in T-cell signalling

J. Garaude , S. Kaminski , S. Cherni , R. A. Hipskind , Martin Villalba
Scandinavian Journal of Immunology, 2005, 62 (6), pp.515--20. ⟨10.1111/j.1365-3083.2005.01696.x⟩
Article dans une revue hal-02262228v1

Positive feedback regulation of PLC gamma 1/Ca2+ signaling by PKC theta in restimulated T cells via a Tec kinase-dependent pathway

A. Altman , S. Kaminski , V. Busuttil , N. Droin , J. R. Hu
European Journal of Immunology, 2004, 34 (7), pp.2001--2011. ⟨10.1002/eji.200324625⟩
Article dans une revue hal-02262400v1

Distinct functions of Vav1 in JNK1 activation in Jurkat T cells versus non-haematopoietic cells

S. Kaminski , M. A. del Pozo , R. A. Hipskind , A. Altman , Martin Villalba
Scandinavian Journal of Immunology, 2004, 59 (6), pp.527--35. ⟨10.1111/j.1365-3083.2004.01429.x⟩
Article dans une revue hal-02262378v1

What came first: PKC theta or the immune synapse?

Martin Villalba
Archivum Immunologiae et Therapiae Experimentalis, 2004, 52 (1), pp.6--12
Article dans une revue hal-02262422v1

Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreading

M. A. Schwartz , J. R. Hu , W. B. Kiosses , A. Altman , Martin Villalba
Journal of Immunology, 2003, 170 (1), pp.41--47. ⟨10.4049/jimmunol.170.1.41⟩
Article dans une revue hal-02239684v1