Mathilde Grelon

Publications

Article dans une revue (38)

Identification of the cytoplasmic motor-LINC complex module involved in meiotic prophase rapid chromosome movements in Arabidopsis thaliana Bowei Cai,Mariana Tiscareno-Andrade,Yanru Luo,Fei Cao,Aurélie Chambonet al. Nature Plants, In press, ⟨10.1038/s41477-025-02043-4⟩ Article dans une revue hal-05207508v1
Control of meiotic crossover interference by a proteolytic chaperone network Heejin Kim,Jaeil Kim,Namil Son,Pallas Kuo,Chris Morganet al. Nature Plants, 2024, 10 (3), pp.453-468. ⟨10.1038/s41477-024-01633-y⟩ Article dans une revue hal-04628359v1
Biochemical characterization of the meiosis-essential yet evolutionarily divergent topoisomerase VIB-like protein MTOPVIB from &lt;i&gt;Arabidopsis thaliana&lt;/i&gt; Hsin-Wen Chen,Hsin-Yi Yeh,Chih-Chiang Chang,Wei-Chen Kuo,Sheng-Wei Linet al. Nucleic Acids Research, 2024, ⟨10.1093/nar/gkae181⟩ Article dans une revue hal-04569399v1
Rapid meiotic prophase chromosome movements in Arabidopsis thaliana are linked to essential reorganization at the nuclear envelope Laurence Cromer,Mariana Tiscareno-Andrade,Sandrine Lefranc,Aurélie Chambon,Aurélie Hurelet al. Nature Communications, 2024, 15 (1), pp.5964. ⟨10.1038/s41467-024-50169-4⟩ Article dans une revue hal-04495019v1
SCEP1 and SCEP2 are two new components of the synaptonemal complex central element Nathalie Vrielynck,Marion Peuch,Stéphanie Durand,Qichao Lian,Aurélie Chambonet al. Nature Plants, 2023, 9 (12), pp.2016-2030. ⟨10.1038/s41477-023-01558-y⟩ Article dans une revue hal-04431974v1
Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage Stéphanie Durand,Qichao Lian,Juli Jing,Marcel Ernst,Mathilde Grelonet al. Nature Communications, 2022, 13 (1), pp.5999. ⟨10.1038/s41467-022-33472-w⟩ Article dans une revue hal-04302040v1
The synaptonemal complex imposes crossover interference and heterochiasmy in Arabidopsis Laia Capilla-Pérez,Stéphanie Durand,Aurélie Hurel,Qichao Lian,Aurélie Chambonet al. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (12), pp.1-11. ⟨10.1073/pnas.2023613118⟩ Article dans une revue hal-03331710v1
Conservation and divergence of meiotic DNA double strand break forming mechanisms in &lt;i&gt;Arabidopsis thaliana&lt;/i&gt; Nathalie Vrielynck,Katja Schneider,Marion Rodriguez,Jason Sims,Aurélie Chambonet al. Nucleic Acids Research, 2021, 49 (17), pp.9821 - 9835. ⟨10.1093/nar/gkab715⟩ Article dans une revue hal-03852634v1
AXR1 affects DNA methylation independently of its role in regulating meiotic crossover localization Nicolas Christophorou,Wenjing She,Jincheng Long,Aurélie Hurel,Sébastien Beaubiatet al. PLoS Genetics, 2020, 16 (6), pp.e1008894. ⟨10.1371/journal.pgen.1008894⟩ Article dans une revue hal-03024379v1
The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis Chao Yang,Kostika Sofroni,Erik Wijnker,Yuki Hamamural,Lena Carstenset al. EMBO Journal, 2019, ⟨10.15252/embj.2019101625⟩ Article dans une revue hal-02622062v1
POLQ plays a key role in the repair of CRISPR/Cas9-induced double-stranded breaks in the moss Physcomitrella patens Kostlend Mara,Florence Charlot,Anouchka Guyon Debast,Didier G. Schaefer,Cécile Collonnieret al. New Phytologist, 2019, 222 (3), pp.1380-1391. ⟨10.1111/nph.15680⟩ Article dans une revue hal-02628938v1
Identification of ASYNAPTIC4, a component of the meiotic chromosome axis Aurélie Chambon,Allan West,Daniel Vezon,Christine Horlow,Arnaud de Muytet al. Plant Physiology, 2018, 178 (1), pp.233-246. ⟨10.1104/pp.17.01725⟩ Article dans une revue hal-02626388v1
The HEM Lines: a new library of homozygous &lt;em&gt;Arabidopsis thaliana&lt;/em&gt; EMS mutants and its potential to detect meiotic phenotypes Laia Capilla-Perez,Victor Solier,Virginie Portemer,Aurélie Chambon,Aurélie Hurelet al. Frontiers in Plant Science, 2018, 9, ⟨10.3389/fpls.2018.01339⟩ Article dans une revue hal-02621030v1
FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination Joiselle Blanche Fernandes,Marine Duhamel,Mathilde Seguéla-Arnaud,Nicole Froger,Chloé Girardet al. PLoS Genetics, 2018, 14 (4), pp.e1007317. ⟨10.1371/journal.pgen.1007317⟩ Article dans une revue hal-04432010v1
A cytological approach to studying meiotic recombination and chromosome dynamics in Arabidopsis thaliana male meiocytes in three dimensions Aurélie Hurel,Dylan Phillips,Nathalie Vrielynck,Christine Mézard,Mathilde Grelonet al. The Plant Journal, 2018, 95 (2), pp.385-396. ⟨10.1111/tpj.13942⟩ Article dans une revue hal-02622140v1
TopoVIL : a molecular scissor essential for reproduction T Robert,Bernard de Massy,M Grelon Médecine/Sciences, 2017, 33 (5), pp.512-518. ⟨10.1051/medsci/20173305015⟩ Article dans une revue hal-01540316v1
Meiotic recombination mechanisms Mathilde Grelon Comptes Rendus. Biologies, 2016, 339 (7-8), pp.247-251. ⟨10.1016/j.crvi.2016.04.003⟩ Article dans une revue hal-04432057v1
A new light on the meiotic DSB catalytic complex T Robert,N Vrielynck,C Mézard,Bernard de Massy,M Grelon Seminars in Cell and Developmental Biology, 2016, 54, pp.165-176. ⟨10.1016/j.semcdb.2016.02.025⟩ Article dans une revue (article de synthèse) hal-01320053v1
A DNA topoisomerase VI-like complex initiates meiotic recombination Nathalie Vrielynck,Aurélie A. Chambon,Daniel Vezon,Lucie L. Pereira,Liudmila L. Chelyshevaet al. Science, 2016, 351 (6276), pp.939-943. ⟨10.1126/science.aad5196⟩ Article dans une revue hal-02637684v1
Where to cross? New insights into the location of meiotic crossovers Christine Mezard,Marina Tagliaro Jahns,Mathilde Grelon Trends in Genetics, 2015, 31 (7), pp.393-401. ⟨10.1016/j.tig.2015.03.008⟩ Article dans une revue hal-01204201v1
Homoeologous chromosome sorting and progression of meiotic recombination in [i]Brassica napus[/i]: ploidy does matter! Laurie Grandont,Nieves Cunado,Olivier Coriton,Virginie Huteau,Frederique Eberet al. The Plant cell, 2014, 26 (4), pp.1448-1463. ⟨10.1105/tpc.114.122788⟩ Article dans une revue hal-01204069v1
RAD51B plays an essential role during somatic and meiotic recombination in Physcomitrella Florence Charlot,Liudmila Chelysheva,Yasuko Kamisugi,Nathalie Vrielynck,Anouchka Guyon Debastet al. Nucleic Acids Research, 2014, 42 (19), pp.11965 - 11978. ⟨10.1093/nar/gku890⟩ Article dans une revue hal-01204143v1
Crossover localisation is regulated by the neddylation posttranslational regulatory pathway Marina Tagliaro Jahns,Daniel Vezon,Aurélie Chambon,Lucie Pereira,Matthieu Falqueet al. PLoS Biology, 2014, 12 (8), ⟨10.1371/journal.pbio.1001930⟩ Article dans une revue hal-01204105v1
Sufficient amounts of functional HOP2/MND1 complex promote interhomolog DNA repair but are dispensable for intersister DNA repair during meiosis in Arabidopsis Clemens Uanschou,Arnaud Ronceret,Mona von Harder,Arnaud de Muyt,Daniel Vezonet al. The Plant cell, 2013, 25 (12), pp.4924-4940. ⟨10.1105/tpc.113.118521⟩ Article dans une revue hal-01204161v1
The Arabidopsis HEI10 Is a New ZMM Protein Related to Zip3 Liudmila Chelysheva,Daniel Vezon,Aurélie Chambon,Ghislaine Gendrot,Lucie Pereiraet al. PLoS Genetics, 2012, 8 (7), ⟨10.1371/journal.pgen.1002799⟩ Article dans une revue hal-01190765v1
Epigenetic remodeling of meiotic crossover frequency in [i]Arabidopsis thaliana[/i] DNA methyltransferase mutants Nataliya E. Yelina,Kyuha Choi,Liudmila Chelysheva,Malcolm Macaulay,Bastiaan de Snooet al. PLoS Genetics, 2012, 8 (8), ⟨10.1371/journal.pgen.1002844⟩ Article dans une revue hal-01190760v1
An easy protocol for studying chromatin and recombination protein dynamics during Arabidopsis thaliana meiosis: immunodetection of cohesins, histones and MLH1 Liudmila Chelysheva,Laurie Grandont,Nathalie Vrielynck,Sylvia Le Guin,Raphaël Mercieret al. Cytogenetic and Genome Research, 2010, 129 (1-3), pp.143-153. ⟨10.1159/000314096⟩ Article dans une revue hal-01203932v1
The Arabidopsis proteasome RPT5 subunits are essential for gametophyte development Jean-Luc J.-L. Gallois,Anouchka Guyon-Debast,Alain A. Lecureuil,Daniel Vezon,V Carpentieret al. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology, 2008, 150 (3), pp.S 178. ⟨10.1016/j.cbpa.2008.04.474⟩ Article dans une revue istex hal-02657516v1
AtPRD1 is required for meiotic double strand break formation in Arabidopsis thaliana Arnaud de Muyt,Daniel Vezon,Ghislaine G. Gendrot,Jean-Luc J.-L. Gallois,Rebecca Stevenset al. EMBO Journal, 2007, 26 (18), pp.4126-4137. ⟨10.1038/sj.emboj.7601815⟩ Article dans une revue hal-02655389v1
AtREC8 and AtSCC3 are essential to the monopolar orientation of the kinetochores during meiosis Liudmila L. Chelysheva,Stéphanie Diallo,Daniel Vezon,Ghislaine G. Gendrot,Nathalie Vrielyncket al. Journal of Cell Science, 2005, 118, pp.4621-4632. ⟨10.1242/jcs.02583⟩ Article dans une revue hal-02682870v1
Two meiotic crossover classes cohabit in Arabidopsis : one is dependent on MER3, whereas the other one is not Raphaël R. Mercier,Sylvie S. Jolivet,Daniel Vezon,Emelyne Huppe,Liudmila L. Chelyshevaet al. Current Biology, 2005, 15 (8), pp.692-701. ⟨10.1016/j.cub.2005.02.056⟩ Article dans une revue hal-02676829v1
A CDC45 homolog in Arabidopsis is essential for meiosis, as shown by RNA interference-induced gene silencing Rebecca Stevens,Mathilde Grelon,Daniel Vezon,- Jae Sung Oh,P. Meyeret al. The Plant cell, 2003, 16 (1), pp.99-113 Article dans une revue hal-02679778v1
The Arabidopsis MEI1 gene encodes a protein with five BRCT domains that is involved in meiosis-specific DNA repair events independent of SPO11 -induced DSBs Mathilde Grelon,Ghislaine Gendrot,Daniel Vezon,G. Pelletier The Plant Journal, 2003, 35, pp.465-475 Article dans une revue hal-02672965v1
AtSPO11-1 is necessary for efficient meiotic recombination in plants Mathilde Grelon,Daniel Vezon,Ghislaine Gendrot,G. Pelletier EMBO Journal, 2001, 20 (3), pp.589-600 Article dans une revue hal-02681071v1
How to characterize meiotic functions in plants? Raphaël R. Mercier,Mathilde Grelon,Daniel Vezon,Christine Horlow,G. Pelletier Biochimie, 2001, 83 (11-12), pp.1023-1028 Article dans une revue hal-02671646v1
The restorer Rfo gene acts post-translationally on the stability of the ORF138 Ogura CMS-associated protein in reproductive tissues of rapeseed cybrids M. Bellaoui,Mathilde Grelon,G. Pelletier,Francoise Budar Plant Molecular Biology, 1999, 40, pp.893-902 Article dans une revue hal-02687238v1
Cloning and characterization of MS5 from Arabidopsis : a gene critical in male meiosis Jerry Glover,Mathilde Grelon,S. Craig,A. Chaudhury,Elizabeth Dennis The Plant Journal, 1998, 15 (3), pp.345-356 Article dans une revue hal-02695744v1
Ogura cytoplasmic male-sterility (CMS)-associated orf138 is translated into a mitochondrial membrane polypeptide in male-sterile Brassica cybrids Mathilde Grelon,Francoise Budar,Sandrine S. Bonhomme,G. Pelletier Molecular and General Genetics MGG, 1994, 243, pp.540-547 Article dans une revue hal-02704066v1

Poster de conférence (3)

Towards the modelling of chromosome movements during meiotic prophase I in Arabidopsis thaliana Anca-Georgina Caranfil,Laurence Cromer,Sandrine Lefranc,Mariana Tiscareno-Andrade,Mathilde Grelonet al. Physics of Life 2025, Mar 2025, Harrogate, United Kingdom Poster de conférence hal-05063498v1
Towards the modeling of chromosome movements during meiotic prophase I in Arabidopsis thaliana Anca-Georgina Caranfil,Laurence Cromer,Sandrine Lefranc,Mathilde Grelon,Philippe Andrey IJPB Symposium 2024. Plant Modeling: Opportunities and Challenges, May 2024, Versailles, France Poster de conférence hal-05063521v1
SCEP1 and SCEP2 are two novel components of the Synaptonemal Complex in Arabidopsis thaliana Nathalie Vrielynck,Marion Peuch,Aurélie Chambon,Mathilde Grelon,Christine Mézard Gordon Research Conference on Meiosis, Jun 2022, New London (New Hampshire), United States Poster de conférence hal-04500798v1

Communication dans un congrès (28)

Rapid prophase chromosome movements: a telomere perspective Mathilde Grelon Meiosis - Ile de France, Jan 2025, Paris, France Communication dans un congrès hal-05195298v1
Rapid chromosome movement during meiotic prophase: Understanding How and Why. Mathilde Grelon Plant genome stability and change 2024, EMBO, Jun 2024, Olomouc, Czech Republic Communication dans un congrès hal-05195312v1
Rapid chromosome movement during meiotic prophase : Understanding How and Why Mathilde Grelon Plant Meiosis Meeting, Adam Mickiewicz University in Poznań, Poland, Sep 2024, Poznan, Poland Communication dans un congrès hal-05195321v1
Modeling meiotic prophase I chromosome movements in Arabidopsis thaliana: what does it take to move a chromosome? Anca-Georgina Caranfil,Sandrine Lefranc,Laurence Cromer,Mathilde Grelon,Philippe Andrey Postdocs and Students Meiosis Workshop 2023, Thomas Robert and Chloé Girard, Dec 2023, Montpellier, France Communication dans un congrès hal-05063562v1
Rapid prophase chromosome movements in Arabidopsis: characterization and mechanisms Mathilde Grelon EMBO workshop on meiosis, EMBO, Jun 2023, Pamhagen, Austria Communication dans un congrès hal-04495577v1
Study of the interplay between meiotic recombination and rapid prophase chromosome movements in Arabidopsis thaliana. Mathilde Grelon Gordon Research Meiosis, Gordon Research Conferences, Jun 2022, New London (New Hampshire), United States Communication dans un congrès hal-04495572v1
Conservation and divergence of the meiotic DNA DSB forming machinery - the case of AtREC114 Mathilde Grelon MAYosis, Meiosis Community in Covid time, May 2021, Online, France Communication dans un congrès hal-04495565v1
Study of the interplay between recombination and rapid chromosome movements during Arabidopsis thaliana meiosis Mathilde Grelon Plant genome stability and change, EMBO, Dec 2021, On Line, France Communication dans un congrès hal-04495558v1
Conservation and divergence of meiotic recombination initiation mechanisms: Insights from Arabidopsis thaliana Mathilde Grelon Versailles-Cologne symposium on Meiosis, IJPB-Versailles and MPIPZ-Cologne, Nov 2020, On line, France Communication dans un congrès hal-04495552v1
Conservation and divergence of meiotic recombination initiation mechanisms: Insights from Arabidopsis thaliana Mathilde Grelon Chromopalooza: A festival to celebrate chromosome biology, Doctoral Program Chromosome Dynamics of the University of Vienna, Feb 2020, Vienne, Austria Communication dans un congrès hal-04495522v1
Understanding the mechanisms that shape the distribution of crossovers along chromosomes during meiosis Mathilde Grelon 2nd COST INDEPTH meeting, COST INDEPTH, Dec 2019, Madrid, Spain Communication dans un congrès hal-04495492v1
Functional insights into the mechanisms of meiotic DSB formation in Arabidopsis thaliana Mathilde Grelon The Genetic Recombination and Genome Rearrangements Conference , FASEB Science Research Conferences, Jul 2019, Steamboat Springs, United States Communication dans un congrès hal-04495500v1
What can we learn from mutants that mis-localize COs ? Mathilde Grelon Multi-National Workshop on Cereal Recombination, Jun 2019, Harpenden, United Kingdom Communication dans un congrès hal-04495478v1
The neddylation pathway regulates the localization of meiotic CO, the pairing of homologous chromosomes and the level of DNA methylation in Arabidopsis thaliana Nicolas Christophorou,Aurélie Hurel,Marina Tagliaro-Jahns,Aurélie Chambon,Daniel Vezonet al. Meiosis Gordon conference, Monica Colaiacovo, Jun 2018, New London (New Hampshire), United States Communication dans un congrès hal-04500853v1
Meiotic-induced DSBs in plants : mechanisms and regulations Mathilde Grelon Journée Réparation/Recombinaison de l'ADN, Apr 2018, Orsay Paris Sud, France Communication dans un congrès hal-04495326v1
The neddylation pathway regulates the localization of meiotic CO, the pairing of homologous chromosomes and the level of DNA methylation in Arabidopsis thaliana Nicolas Christophorou,Aurélie Hurel,Yassir Idir,Marina Tagliaro-Jahns,Daniel Vezonet al. Symposium on Chromosome Biology, Rachel Wang, Dec 2018, Taipei (Taiwan), Taiwan Communication dans un congrès hal-04500881v1
Meiotic-induced DSBs in plants: mechanisms and regulations Mathilde Grelon Mini-Symposium on Chromosome biology, Dec 2018, Taipei, Taiwan Communication dans un congrès hal-04495334v1
The Arabidopsis proteasome RPT5 subunits are essential for gametophyte development Jean-Luc Gallois,Anouchka Debast Guyon,Alain Lecureuil,Daniel Vezon,V Carpentieret al. Annual Meeting of the Society-for-Experimental-Biology, Jul 2008, Marseille, France Communication dans un congrès hal-01600978v1
Meiosis in plants requires a SPO11 ortholog Mathilde Grelon,Daniel Vezon,Ghislaine Gendrot,G. Pelletier The Gordon Research Conference on Meiosis, Jun 2000, New London, United States Communication dans un congrès hal-02769657v1
Isolation and characterization of Arabidopsis thaliana mutants exhibiting alterations in meiosis. Daniel Vezon,Christine Horlow,Ghislaine Gendrot,Mathilde Grelon,G. Pelletier Meiosis Gordon Conference, Jun 1998, New London, United States. n.p Communication dans un congrès hal-02839012v1
Gènes mitochondriaux et stérilité mâle Francoise Budar,M. Bellaoui,Sandrine S. Bonhomme,Mathilde Grelon,- Pelletier Colloque de Génétique végétale, Jan 1996, Versailles, France Communication dans un congrès hal-02767874v1
New concepts in rapeseed F1 hybrid breeding M. Renard,Régine Delourme,Patrick Vallée,J. Morice,J. Pierreet al. 9. International Rapeseed Congress, Jul 1995, Cambridge, United Kingdom Communication dans un congrès hal-02775706v1
Engineering of cytoplasmic male sterility in vegetables by protoplast fusion G. Pelletier,Madina Ferault,Dominique Lancelin,Lionel Boulidard,C. Doreet al. International Horticultural Congress, Aug 1994, Kyoto, Japan Communication dans un congrès hal-02777301v1
Ogura CMS associated ORF38 is translated into a mitochondrial membrane polypeptide in male-sterile Brassica cybrids Mathilde Grelon,Francoise Budar,Sandrine S. Bonhomme,G. Pelletier 4. International congress, Jun 1994, Amsterdam, Netherlands Communication dans un congrès hal-02776247v1
Molecular basis of Ogura cytoplasmic male sterility in rapeseed cybrids Francoise Budar,Mathilde Grelon,Sandrine S. Bonhomme,G. Pelletier 15. International Botanical Congress, Aug 1993, Yokohama, Japan Communication dans un congrès hal-02772137v1
Molecular analysis of a mitochondrial DNA fragment correlated with Ogura cytoplasmic male sterility in Brassica cybrids Sandrine S. Bonhomme,Francoise Budar,Mathilde Grelon,G. Pelletier 13. Congres EUCARPIA, Jul 1992, Angers, France. pp.63-64 Communication dans un congrès hal-02843948v1
Molecular analysis of a mitochondrial DNA fragment correlated with Ogura cytoplasmic male sterility in Brassica cybrids Sandrine S. Bonhomme,Mathilde Grelon,Francoise Budar,G. Pelletier International workshop : Molecular control of flower development plant reproduction, Apr 1992, Amsterdam, Netherlands. pp.42 Communication dans un congrès hal-02844142v1
Molecular analysis of a mitochondrial DNA fragment correlated with Ogura cytoplasmic male sterility in Brassica cybrids Sandrine S. Bonhomme,Francoise Budar,Mathilde Grelon,G. Pelletier Interactions of 3 genomes, Sep 1992, Berlin, Germany Communication dans un congrès hal-02773889v1

Autre publication scientifique (1)

Rapid prophase chromosome movements during Arabidopsis thaliana meiosis : Mechanisms and Functional insights Mathilde Grelon 2025 Autre publication scientifique hal-05195379v1

Pré-publication, Document de travail (1)

Dual control of meiotic crossover patterning Stéphanie Durand,Qichao Lian,Juli Jing,Marcel Ernst,Mathilde Grelonet al. 2022 Pré-publication, Document de travail hal-03744286v1

Ouvrages (2)

Plant meiosis: A fertile field Mathilde Grelon,Raphaël Mercier Springer Nature Link. Plant Reproduction, collection, 2022 Ouvrages hal-05195418v1
Plant meiosis, methods and protocols Wojciech P. Pawlowski,Mathilde Grelon,Susan Armstrong Humana press, 990, 238p., 2013, Methods in Molecular Biology, 978-1-62703-332-9. ⟨10.1007/978-1-62703-333-6⟩ Ouvrages hal-01204085v1

Chapitre d'ouvrage (3)

The Molecular Biology of Meiosis in Plants Raphaël Mercier,Christine Mezard,Eric Jenczewski,Nicolas Macaisne,Mathilde Grelon Annu Rev Plant Biol., 66, ANNUAL REVIEWS, pp.31, 2015, Annual Review of Plant Biology, 978-0-8243-0666-3. ⟨10.1146/annurev-arplant-050213-035923⟩ Chapitre d'ouvrage hal-01204185v1
La méiose Christine Mézard,Nicolas Macaisne,Mathilde Grelon La reproduction animale et humaine, Editions Quae, 2014 Chapitre d'ouvrage hal-01204084v1
Immunolocalization of meiotic proteins in Brassicaceae: method 1 Liudmila Chelysheva,Laurie Grandont,Mathilde Grelon Plant Meiosis, Methods and Protocols, 990, Springer, 2013, Methods in Molecular Biology, 1940-6029. ⟨10.1007/978-1-62703-333-6_9⟩ Chapitre d'ouvrage hal-01204089v1

Thèse (1)

Etude du déterminisme de la stérilité mâle cytoplasmique ogura chez les brassicacées Mathilde Grelon Sciences du Vivant [q-bio]. Université Paris Sud - Paris 11, 1995. Français. ⟨NNT : ⟩ Thèse tel-02851809v1