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Matteo Mangoni



thematique de recherche


State-of-the-Art Differentiation Protocols for Patient-Derived Cardiac Pacemaker Cells

Eleonora Torre , Matteo Mangoni , Alain Lacampagne , Albano Meli , Pietro Mesirca
International Journal of Molecular Sciences, 2024, 25 (6), pp.3387. ⟨10.3390/ijms25063387⟩
Journal articles hal-04524782v1

Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine

Pietro Mesirca , Jean Chemin , Christian Barrère , Eleonora Torre , Laura Gallot
Nature Communications, 2024, 15 (1), pp.54. ⟨10.1038/s41467-023-43502-w⟩
Journal articles hal-04385916v1

Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility

Roman Tikhomirov , Robert Oakley , Cali Anderson , Yirong Xiang , Sami Al Othman
Circulation Research, 2024, ⟨10.1161/CIRCRESAHA.123.323464⟩
Journal articles hal-04524430v1
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State-of-the-Art Differentiation Protocols for Patient-Derived Cardiac Pacemaker Cells

Eleonora Torre , Matteo Mangoni , Alain Lacampagne , Albano Meli , Pietro Mesirca
International Journal of Molecular Sciences, 2024, 25 (6), pp.3387. ⟨10.3390/ijms25063387⟩
Journal articles hal-04510562v1
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Lipopolysaccharide-induced sepsis impairs M2R-GIRK signaling in the mouse sinoatrial node

Niroj Shrestha , Klaus Zorn-Pauly , Pietro Mesirca , Chintan N Koyani , Gerald Wölkart
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (28), pp.e2210152120. ⟨10.1073/pnas.2210152120⟩
Journal articles hal-04271641v1
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Impact of stress on cardiac phenotypes in mice harboring an ankyrin-B disease variant

Michael J Wallace , Nipun Malhotra , Juan Ignacio Elio Mariángelo , Tyler L Stevens , Lindsay J Young
Journal of Biological Chemistry, 2023, 299 (6), pp.104818. ⟨10.1016/j.jbc.2023.104818⟩
Journal articles hal-04271860v1
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Heart rate reduction after genetic ablation of L-type Cav1.3 channels induces cardioprotection against ischemia-reperfusion injury

Viviana Delgado-Betancourt , Kroekkiat Chinda , Pietro Mesirca , Christian Barrère , Aurélie Covinhes
Frontiers in Cardiovascular Medicine, 2023, 10, pp.1134503. ⟨10.3389/fcvm.2023.1134503⟩
Journal articles hal-04184437v1
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High-speed optical mapping of heart and brain voltage activities in zebrafish larvae exposed to environmental contaminants

Solène Micou , Isabel Forner-Piquer , Noémie Cresto , Tess Zassot , Aurélien Drouard
Environmental Technology and Innovation, 2023, 31, pp.103196. ⟨10.1016/j.eti.2023.103196⟩
Journal articles hal-04240603v1
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Optical Control of Cardiac Rhythm by In Vivo Photoactivation of an ERG Channel Peptide Inhibitor

Jérôme Montnach , Hugo Millet , Antoine Persello , Hervé Meudal , Stephan de Waard
Circulation Research, 2023, 133 (6), pp.535-538. ⟨10.1161/CIRCRESAHA.123.322880⟩
Journal articles hal-04225427v1
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Characterization of sinoatrial automaticity in Microcebus murinus to study the effect of aging on cardiac activity and the correlation with longevity

Mattia Difrancesco , Manon Marrot , Eleonora Torre , Pietro Mesirca , Romain Davaze
Scientific Reports, 2023, 13 (1), pp.3054. ⟨10.1038/s41598-023-29723-5⟩
Journal articles hal-04010411v1
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L-Type Cav1.3 Calcium Channels Are Required for Beta-Adrenergic Triggered Automaticity in Dormant Mouse Sinoatrial Pacemaker Cells

Julien Louradour , Olivier Bortolotti , Eleonora Torre , Isabelle Bidaud , Ned Lamb
Cells, 2022, 11 (7), pp.1114. ⟨10.3390/cells11071114⟩
Journal articles hal-03628407v1
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Pharmacologic Approach to Sinoatrial Node Dysfunction

Pietro Mesirca , Vadim Fedorov , Thomas Hund , Angelo Torrente , Isabelle Bidaud
Annual Review of Pharmacology and Toxicology, 2021, 61, pp.757-778. ⟨10.1146/annurev-pharmtox-031120-115815⟩
Journal articles hal-02960337v1
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ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research

Katja Odening , Ana-Maria Gomez , Dobromir Dobrev , Larissa Fabritz , Frank Heinzel
EP-Europace, 2021, 23 (11), pp.1795-1814. ⟨10.1093/europace/euab142⟩
Journal articles hal-03437471v1
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Genetic Complexity of Sinoatrial Node Dysfunction

Michael Wallace , Mona El Refaey , Pietro Mesirca , Thomas Hund , Matteo Mangoni
Frontiers in Genetics, 2021, 12, ⟨10.3389/fgene.2021.654925⟩
Journal articles hal-03437525v1
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Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes

Pietro Mesirca , Shu Nakao , Sarah Dalgas Nissen , Gabriella Forte , Cali Anderson
Circulation Research, 2021, 129 (1), pp.e1-e20. ⟨10.1161/CIRCRESAHA.119.316386⟩
Journal articles hal-03437523v1

The funny current in genetically modified mice

Mattia Difrancesco , Pietro Mesirca , Isabelle Bidaud , Dirk Isbrandt , Matteo E. Mangoni
Progress in Biophysics and Molecular Biology, 2021, ⟨10.1016/j.pbiomolbio.2021.06.003⟩
Journal articles hal-03263876v1
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Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease

Mark Boyett , Joseph Yanni , James Tellez , Annalisa Bucchi , Pietro Mesirca
Progress in Biophysics and Molecular Biology, 2021, 166, pp.61-85. ⟨10.1016/j.pbiomolbio.2021.06.008⟩
Journal articles hal-03437472v1
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Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity

Daniel Turner , Chen Kang , Pietro Mesirca , Juan Hong , Matteo E. Mangoni
Frontiers in Cardiovascular Medicine, 2021, 8, ⟨10.3389/fcvm.2021.662410⟩
Journal articles hal-03437522v1
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Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels Prevents Training-Induced Sinus Bradycardia

Isabelle Bidaud , Alicia D’souza , Gabriella Forte , Eleonora Torre , Denis Greuet
Frontiers in Physiology, 2021, 11, ⟨10.3389/fphys.2020.519382⟩
Journal articles hal-03437526v1
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The funny current in genetically modified mice

Mattia Difrancesco , Pietro Mesirca , Isabelle Bidaud , Dirk Isbrandt , Matteo Mangoni
Progress in Biophysics and Molecular Biology, 2021, 166, pp.39-50. ⟨10.1016/j.pbiomolbio.2021.06.003⟩
Journal articles hal-03437498v1
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A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate

Alicia D’souza , Yanwen Wang , Cali Anderson , Annalisa Bucchi , Mirko Baruscotti
Heart Rhythm, 2021, 18 (5), pp.801-810. ⟨10.1016/j.hrthm.2020.11.026⟩
Journal articles hal-03437524v1
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Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity

Matthias Baudot , Eleonora Torre , Isabelle Bidaud , Julien Louradour , Angelo G Torrente
Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-76049-7⟩
Journal articles hal-03013849v1
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Channelopathies of voltage-gated L-type Cav1.3/α1D and T-type Cav3.1/α1G Ca2+ channels in dysfunction of heart automaticity

Angelo Torrente , Pietro Mesirca , Isabelle Bidaud , Matteo E. Mangoni
Pflügers Archiv European Journal of Physiology, 2020, 472 (7), pp.817 - 830. ⟨10.1007/s00424-020-02421-1⟩
Journal articles hal-02892374v1
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Maurocalcin and its analogue MCaE12A facilitate Ca2+ mobilization in cardiomyocytes

Stephan de Waard , Jérome Montnach , Charly Cortinovis , Olfa Chkir , Morteza Erfanian
Biochemical Journal, 2020, Online ahead of print. ⟨10.1042/BCJ20200206⟩
Journal articles inserm-02968252v1
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Inhibition of G protein-gated K+ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia

Isabelle Bidaud , Antony Chung You Chong , Agnès Carcouët , Stephan De Waard , Flavien Charpentier
Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-66673-8⟩
Journal articles hal-02885001v1
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Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

Stephan de Waard , Jérôme Montnach , Barbara Ribeiro , Sébastien Nicolas , Virginie Forest
International Journal of Molecular Sciences, 2020, 2020, ⟨10.3390/ijms21197167⟩
Journal articles hal-02951542v1
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Génération de la fonction sinusale et perspectives thérapeutiques

Pietro Mesirca , A.-G. Torrente , Isabelle Bidaud , M. Baudot , Joël Nargeot
Archives des Maladies du Coeur et des Vaisseaux - Pratique, 2018, 2018 (267), pp.35 - 39. ⟨10.1016/j.amcp.2018.02.007⟩
Journal articles hal-02440724v1
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A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

A. Saponaro , F. Cantini , A. Porro , A. Bucchi , D. Difrancesco
Journal articles hal-02073210v1
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CaV1.3 L-type Ca2+ channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na+ current

Futoshi Toyoda , Pietro Mesirca , Stefan Dübel , Wei-Guang Ding , Joerg Striessnig
Scientific Reports, 2017, 7 (1), pp.7869. ⟨10.1038/s41598-017-08191-8⟩
Journal articles hal-01778161v1
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Clock-dependent and system-driven oscillators interact in the suprachiasmatic nuclei to pace mammalian circadian rhythms

Karine Abitbol , Segolene Debiesse , François Molino , Pietro Mesirca , Isabelle Bidaud
PLoS ONE, 2017, 12 (10), pp.e0187001. ⟨10.1371/journal.pone.0187001⟩
Journal articles hal-01724552v1
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L-type Ca v 1.3 channels regulate ryanodine receptor-dependent Ca 2+ release during sino-atrial node pacemaker activity

Angelo Torrente , Pietro Mesirca , Patricia Neco , Riccardo Rizzetto , Stefan Dübel
Cardiovascular Research, 2016, 109 (3), pp.451-461. ⟨10.1093/cvr/cvw006⟩
Journal articles hal-01792471v1
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G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block

Pietro Mesirca , Isabelle Bidaud , François Briec , Stéphane Evain , Angelo G. Torrente
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (7), pp.E932--941. ⟨10.1073/pnas.1517181113⟩
Journal articles hal-01831593v1
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Rescuing cardiac automaticity in L-type Cav1.3 channelopathies and beyond

Pietro Mesirca , Isabelle Bidaud , Matteo E. Mangoni
The Journal of Physiology, 2016, ⟨10.1113/JP270678⟩
Journal articles hal-01942452v1
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Desmosomes and sino-atrial dysfunction

Matteo E. Mangoni
Cardiovascular Research, 2016, 111 (3), pp.167--168. ⟨10.1093/cvr/cvw171⟩
Journal articles hal-01940738v1
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Comment on: 'Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia'

Adèle Faucherre , K. Kissa , Joël Nargeot , Matteo E. Mangoni , Chris Jopling
Haematologica, 2016, 101 (1), pp.e38. ⟨10.3324/haematol.2015.137398⟩
Journal articles hal-01940741v1

Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation

Pietro Mesirca , J. Alig , Angelo Torrente , J.C Muller , L. Marger
Nature Communications, 2014, 5, pp.4664. ⟨10.1038/ncomms5664⟩
Journal articles hal-01059204v1

Paradoxical Effect of Increased Diastolic Ca 2+ Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

Patricia Neco , Angelo Torrente , Pietro Mesirca , Esther Zorio , Nian Liu
Circulation, 2012, 126 (4), pp.392-401. ⟨10.1161/CIRCULATIONAHA.111.075382⟩
Journal articles hal-02477214v1

Identification of Potential Pharmacological Targets by Analysis of the Comprehensive G Protein-Coupled Receptor Repertoire in the Four Cardiac Chambers

Thomas Moore-Morris , Annie Varrault , Matteo E. Mangoni , Anne Le Digarcher , V. Negre
Molecular Pharmacology, 2009, 75 (5), pp.1108 - 1116. ⟨10.1124/mol.108.054155⟩
Journal articles hal-01788903v1

Voltage-dependent calcium channels and cardiac pacemaker activity: From ionic currents to genes

Matteo E. Mangoni , Brigitte Couette , L. Marger , Emmanuel Bourinet , J. Striessnig
Progress in Biophysics and Molecular Biology, 2006, 90, pp.38-63. ⟨10.1016/j.pbiomolbio.2005.05.003⟩
Journal articles hal-00017071v1

Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart

C. Marionneau , Brigitte Couette , J. Liu , H. Li , Matteo E. Mangoni
The Journal of Physiology, 2005, 562, pp.223-234. ⟨10.1113/jphysiol.2004.074047⟩
Journal articles hal-00017075v1