Matteo Mangoni

Présentation

thematique de recherche

Publications

Article dans une revue (42)

L-Type Cav1.3 and HCN Channels Mediate Heart Rate Acceleration by Catecholamines Eleonora Torre,Mélanie Faure,Isabelle Bidaud,Matthias Baudot,Marvin Gaillardonet al. Circulation Research, 2026, 138 (1), pp.e327497. ⟨10.1161/circresaha.125.327497⟩ Article dans une revue hal-05458199v1
Extracellular activation of HCN4 by a subtype-specific nanobody Atiyeh Sadat Sharifzadeh,Roberta Castelli,Alessandro Porro,Pietro Mesirca,Romain Perrieret al. Nature Communications, 2025, 16 (1), pp.10804. ⟨10.1038/s41467-025-65852-3⟩ Article dans une revue hal-05392443v1
Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility Roman Tikhomirov,Robert Oakley,Cali Anderson,Yirong Xiang,Sami Al Othmanet al. Circulation Research, 2024, 134 (10), pp.1306-1326. ⟨10.1161/CIRCRESAHA.123.323464⟩ Article dans une revue hal-04524430v1
State-of-the-Art Differentiation Protocols for Patient-Derived Cardiac Pacemaker Cells Eleonora Torre,Matteo Mangoni,Alain Lacampagne,Albano C. Meli,Pietro Mesirca International Journal of Molecular Sciences, 2024, 25 (6), pp.3387. ⟨10.3390/ijms25063387⟩ Article dans une revue (article de synthèse) hal-04524782v1
Selective blockade of Ca$_V$1.2 (α1C) versus Ca$_V$1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine Pietro Mesirca,Jean Chemin,Christian Barrère,Eleonora Torre,Laura Gallotet al. Nature Communications, 2024, 15 (1), pp.54. ⟨10.1038/s41467-023-43502-w⟩ Article dans une revue hal-04385916v1
Computational modelling of mouse atrio ventricular node action potential and automaticity Chiara Bartolucci,Pietro Mesirca,Eugenio Ricci,Clara Sales‐bellés,Eleonora Torreet al. The Journal of Physiology, 2024, 602 (19), pp.4821-4847. ⟨10.1113/JP285950⟩ Article dans une revue hal-04780628v1
Lipopolysaccharide-induced sepsis impairs M2R-GIRK signaling in the mouse sinoatrial node Niroj Shrestha,Klaus Zorn-Pauly,Pietro Mesirca,Chintan N Koyani,Gerald Wölkartet al. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (28), pp.e2210152120. ⟨10.1073/pnas.2210152120⟩ Article dans une revue hal-04271641v1
High-speed optical mapping of heart and brain voltage activities in zebrafish larvae exposed to environmental contaminants Solène Micou,Isabel Forner-Piquer,Noémie Cresto,Tess Zassot,Aurélien Drouardet al. Environmental Technology and Innovation, 2023, 31, pp.103196. ⟨10.1016/j.eti.2023.103196⟩ Article dans une revue hal-04240603v1
Impact of stress on cardiac phenotypes in mice harboring an ankyrin-B disease variant Michael J Wallace,Nipun Malhotra,Juan Ignacio Elio Mariángelo,Tyler L Stevens,Lindsay J Younget al. Journal of Biological Chemistry, 2023, 299 (6), pp.104818. ⟨10.1016/j.jbc.2023.104818⟩ Article dans une revue hal-04271860v1
Heart rate reduction after genetic ablation of L-type Cav1.3 channels induces cardioprotection against ischemia-reperfusion injury Viviana Delgado-Betancourt,Kroekkiat Chinda,Pietro Mesirca,Christian Barrère,Aurélie Covinheset al. Frontiers in Cardiovascular Medicine, 2023, 10, pp.1134503. ⟨10.3389/fcvm.2023.1134503⟩ Article dans une revue hal-04184437v1
Characterization of sinoatrial automaticity in Microcebus murinus to study the effect of aging on cardiac activity and the correlation with longevity Mattia Difrancesco,Manon Marrot,Eleonora Torre,Pietro Mesirca,Romain Davazeet al. Scientific Reports, 2023, 13 (1), pp.3054. ⟨10.1038/s41598-023-29723-5⟩ Article dans une revue hal-04010411v1
Optical Control of Cardiac Rhythm by In Vivo Photoactivation of an ERG Channel Peptide Inhibitor Jérôme Montnach,Hugo Millet,Antoine Persello,Hervé Meudal,Stephan de Waardet al. Circulation Research, 2023, 133 (6), pp.535-538. ⟨10.1161/CIRCRESAHA.123.322880⟩ Article dans une revue hal-04225427v1
L-Type Cav1.3 Calcium Channels Are Required for Beta-Adrenergic Triggered Automaticity in Dormant Mouse Sinoatrial Pacemaker Cells Julien Louradour,Olivier Bortolotti,Eleonora Torre,Isabelle Bidaud,Ned Lambet al. Cells, 2022, 11 (7), pp.1114. ⟨10.3390/cells11071114⟩ Article dans une revue hal-03628407v1
Pharmacologic Approach to Sinoatrial Node Dysfunction Pietro Mesirca,Vadim Fedorov,Thomas Hund,Angelo Torrente,Isabelle Bidaudet al. Annual Review of Pharmacology and Toxicology, 2021, 61, pp.757-778. ⟨10.1146/annurev-pharmtox-031120-115815⟩ Article dans une revue hal-02960337v1
ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research Katja Odening,Ana Maria Gómez,Dobromir Dobrev,Larissa Fabritz,Frank Heinzelet al. EP-Europace, 2021, 23 (11), pp.1795-1814. ⟨10.1093/europace/euab142⟩ Article dans une revue hal-03437471v1
Genetic Complexity of Sinoatrial Node Dysfunction Michael Wallace,Mona El Refaey,Pietro Mesirca,Thomas J Hund,Matteo Mangoniet al. Frontiers in Genetics, 2021, 12, pp.654925. ⟨10.3389/fgene.2021.654925⟩ Article dans une revue (article de synthèse) hal-03437525v1
Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease Mark Boyett,Joseph Yanni,James Tellez,Annalisa Bucchi,Pietro Mesircaet al. Progress in Biophysics and Molecular Biology, 2021, 166, pp.61-85. ⟨10.1016/j.pbiomolbio.2021.06.008⟩ Article dans une revue hal-03437472v1
Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes Pietro Mesirca,Shu Nakao,Sarah Dalgas Nissen,Gabriella Forte,Cali Andersonet al. Circulation Research, 2021, 129 (1), pp.e1-e20. ⟨10.1161/CIRCRESAHA.119.316386⟩ Article dans une revue hal-03437523v1
A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate Alicia D’souza,Yanwen Wang,Cali Anderson,Annalisa Bucchi,Mirko Baruscottiet al. Heart Rhythm, 2021, 18 (5), pp.801-810. ⟨10.1016/j.hrthm.2020.11.026⟩ Article dans une revue hal-03437524v1
Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels Prevents Training-Induced Sinus Bradycardia Isabelle Bidaud,Alicia D’souza,Gabriella Forte,Eleonora Torre,Denis Greuetet al. Frontiers in Physiology, 2021, 11, pp.519382. ⟨10.3389/fphys.2020.519382⟩ Article dans une revue hal-03437526v1
The funny current in genetically modified mice Mattia Lorenzo Difrancesco,Pietro Mesirca,Isabelle Bidaud,Dirk Isbrandt,Matteo Mangoni Progress in Biophysics and Molecular Biology, 2021, 166, pp.39-50. ⟨10.1016/j.pbiomolbio.2021.06.003⟩ Article dans une revue hal-03437498v1
Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity Daniel Turner,Chen Kang,Pietro Mesirca,Juan Hong,Matteo E. Mangoniet al. Frontiers in Cardiovascular Medicine, 2021, 8, pp.662410. ⟨10.3389/fcvm.2021.662410⟩ Article dans une revue hal-03437522v1
Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity Matthias Baudot,Eleonora Torre,Isabelle Bidaud,Julien Louradour,Angelo G Torrenteet al. Scientific Reports, 2020, 10 (1), pp.18906. ⟨10.1038/s41598-020-76049-7⟩ Article dans une revue hal-03013849v1
Channelopathies of voltage-gated L-type Cav1.3/α1D and T-type Cav3.1/α1G Ca2+ channels in dysfunction of heart automaticity Angelo Torrente,Pietro Mesirca,Isabelle Bidaud,Matteo E. Mangoni Pflügers Archiv European Journal of Physiology, 2020, 472 (7), pp.817 - 830. ⟨10.1007/s00424-020-02421-1⟩ Article dans une revue hal-02892374v1
Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells Stephan de Waard,Jérôme Montnach,Barbara Ribeiro,Sébastien Nicolas,Virginie Forestet al. International Journal of Molecular Sciences, 2020, 21 (19), pp.7167. ⟨10.3390/ijms21197167⟩ Article dans une revue hal-02951542v1
Inhibition of G protein-gated K+ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia Isabelle Bidaud,Antony Chung You Chong,Agnès Carcouët,Stephan De Waard,Flavien Charpentieret al. Scientific Reports, 2020, 10 (1), pp.9835. ⟨10.1038/s41598-020-66673-8⟩ Article dans une revue hal-02885001v1
Maurocalcin and its analogue MCaE12A facilitate Ca2+ mobilization in cardiomyocytes Stephan de Waard,Jérôme Montnach,Charly Cortinovis,Olfa Chkir,Morteza Erfanianet al. Biochemical Journal, 2020, 477 (20), pp.3985-3999. ⟨10.1042/BCJ20200206⟩ Article dans une revue inserm-02968252v1
Mitochondria and L-Type Ca2+ channels interplay in the regulation of Ca2+ dynamics in murine pacemaker cells L. Fossier,Angelo Torrente,J. Louradour,I. Bidaud,Matteo E. Mangoniet al. Archives of Cardiovascular Diseases Supplements, 2019, 11 (2), pp.266-267. ⟨10.1016/j.acvdsp.2019.02.180⟩ Article dans une revue hal-04723899v1
Génération de la fonction sinusale et perspectives thérapeutiques Pietro Mesirca,A.-G. Torrente,Isabelle Bidaud,M. Baudot,Joël Nargeotet al. Archives des Maladies du Coeur et des Vaisseaux - Pratique, 2018, 2018 (267), pp.35 - 39. ⟨10.1016/j.amcp.2018.02.007⟩ Article dans une revue hal-02440724v1
A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels A. Saponaro,F. Cantini,A. Porro,A. Bucchi,D. Difrancescoet al. eLife, 2018, 7, ⟨10.7554/eLife.35753⟩ Article dans une revue hal-02073210v1
CaV1.3 L-type Ca2+ channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na+ current Futoshi Toyoda,Pietro Mesirca,Stefan Dübel,Wei-Guang Ding,Joerg Striessniget al. Scientific Reports, 2017, 7 (1), pp.7869. ⟨10.1038/s41598-017-08191-8⟩ Article dans une revue hal-01778161v1
Clock-dependent and system-driven oscillators interact in the suprachiasmatic nuclei to pace mammalian circadian rhythms Karine Abitbol,Segolene Debiesse,François Molino,Pietro Mesirca,Isabelle Bidaudet al. PLoS ONE, 2017, 12 (10), pp.e0187001. ⟨10.1371/journal.pone.0187001⟩ Article dans une revue hal-01724552v1
G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block Pietro Mesirca,Isabelle Bidaud,François Briec,Stéphane Evain,Angelo G. Torrenteet al. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (7), pp.E932--941. ⟨10.1073/pnas.1517181113⟩ Article dans une revue hal-01831593v1
Comment on: 'Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia Adèle Faucherre,K. Kissa,Joël Nargeot,Matteo E. Mangoni,Chris Jopling Haematologica, 2016, 101 (1), pp.e38. ⟨10.3324/haematol.2015.137398⟩ Article dans une revue hal-01940741v1
Desmosomes and sino-atrial dysfunction Matteo E. Mangoni Cardiovascular Research, 2016, 111 (3), pp.167--168. ⟨10.1093/cvr/cvw171⟩ Article dans une revue hal-01940738v1
Rescuing cardiac automaticity in L-type Cav1.3 channelopathies and beyond Pietro Mesirca,Isabelle Bidaud,Matteo E. Mangoni The Journal of Physiology, 2016, ⟨10.1113/JP270678⟩ Article dans une revue hal-01942452v1
L-type Ca v 1.3 channels regulate ryanodine receptor-dependent Ca 2+ release during sino-atrial node pacemaker activity Angelo Torrente,Pietro Mesirca,Patricia Neco,Riccardo Rizzetto,Stefan Dübelet al. Cardiovascular Research, 2016, 109 (3), pp.451-461. ⟨10.1093/cvr/cvw006⟩ Article dans une revue hal-01792471v1
Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation Pietro Mesirca,J. Alig,Angelo Torrente,J.C Muller,L. Margeret al. Nature Communications, 2014, 5, pp.4664. ⟨10.1038/ncomms5664⟩ Article dans une revue hal-01059204v1
Paradoxical Effect of Increased Diastolic Ca 2+ Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia Patricia Neco,Angelo Torrente,Pietro Mesirca,Esther Zorio,Nian Liuet al. Circulation, 2012, 126 (4), pp.392-401. ⟨10.1161/CIRCULATIONAHA.111.075382⟩ Article dans une revue hal-02477214v1
Identification of Potential Pharmacological Targets by Analysis of the Comprehensive G Protein-Coupled Receptor Repertoire in the Four Cardiac Chambers Thomas Moore-Morris,Annie Varrault,Matteo E. Mangoni,Anne Le Digarcher,V. Negreet al. Molecular Pharmacology, 2009, 75 (5), pp.1108 - 1116. ⟨10.1124/mol.108.054155⟩ Article dans une revue hal-01788903v1
Voltage-dependent calcium channels and cardiac pacemaker activity: From ionic currents to genes Matteo E. Mangoni,Brigitte Couette,L. Marger,Emmanuel Bourinet,J. Striessniget al. Progress in Biophysics and Molecular Biology, 2006, 90, pp.38-63. ⟨10.1016/j.pbiomolbio.2005.05.003⟩ Article dans une revue istex hal-00017071v1
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart C. Marionneau,Brigitte Couette,J. Liu,H. Li,Matteo E. Mangoniet al. The Journal of Physiology, 2005, 562, pp.223-234. ⟨10.1113/jphysiol.2004.074047⟩ Article dans une revue hal-00017075v1

Communication dans un congrès (5)

Calciseptine isolated from the black mamba toxin selectively blocks cardiac Cav1.2 (alpha1C) versus Cav1.3 (alpha1D) L-type calcium channels Pietro Mesirca,Jean Chemin,Christian Barrère,Eleonora Torre,Laura Gallotet al. Meeting of the Southeast Asian section of the International Society for Heart Research World, ISHR-SEA, Oct 2024, Singapour, Singapore. pp.100123, ⟨10.1016/j.jmccpl.2024.100123⟩ Communication dans un congrès hal-05402290v1
Consequences of aging on the adaptative capacity of Microcebus murinus heart to stress Manon Marrot,Yasmine Colombani,Joel Cuoq,Pascaline Fontes,Faustine Hugonet al. 38th Meeting of the European Section of International Society, Jun 2024, Toulouse, France Communication dans un congrès hal-04789810v1
L-type Cav1.3 channels as key effectors of heart rate acceleration by catecholamines Melanie Anna Faure,Eleonora Torre,Isabelle Bidaud,Marvin Gaillardon,Stéphanie Barrère-Lemaireet al. meeting of the european section of the International Society of Heart Research, ISHR, Jun 2024, Toulouse, France. pp.100106, ⟨10.1016/j.jmccpl.2024.100106⟩ Communication dans un congrès hal-05402526v1
Cholinergic regulation of cardiac pacemaker activity by l-type cav1.3 channels Leïla Talssi,Isabelle Bidaud,Pietro Mesirca,Matteo E. Mangoni ESC Congress 2020 – The Digital Experience, European Society of Cardiology, Aug 2020, Virtuel - Online, Netherlands. pp.3597, ⟨10.1093/ehjci/ehaa946.3597⟩ Communication dans un congrès hal-04773146v1
Functional role for the GIRK1/4, Cav1.3 and HCN4 channels in muscarinic regulation of heart rate Leïla Talssi,Isabelle Bidaud,Matteo Elia Mangoni,Pietro Mesirca 86th Congress of French Physiological Society, Nouvelle Faculté de Médecine, Jun 2019, Montpellier, France. pp.46, ⟨10.1111/apha.13389⟩ Communication dans un congrès hal-04730581v1

Poster de conférence (4)

Calciseptine isolated from the black mamba toxin selectively blocks cardiac Cav1.2 (alpha1C) versus Cav1.3 (alpha1D) L-type calcium channels Pietro Mesirca,Jean Chemin,Christian Barrere,Eleonora Torre,Laura Gallotet al. 38th Meeting of the European Section of International Society, Jun 2024, Toulouse, France Poster de conférence hal-04789795v1
L-type Cav1.3 channels as key effectors of heart rate acceleration by catecholamines Melanie Faure,Eleonora Torre,Isabelle Bidaud,Marvin Gaillardon,Stéphanie Barrère-Lemaireet al. 38th Meeting of the European Section of International Society, Jun 2024, Toulouse, France Poster de conférence hal-04789809v1
Evidence for a selective blockade of Cav1.2 versus Cav1.3 by the mamba toxin calciseptine in the mouse heart Stéphanie Barrère-Lemaire,Christian Barrère,K. Chinda,Pietro Mesirca,C. Aurélieet al. ECongrès le Printemps de la Cardiologie, Oct 2020, grenoble, France. 12 (2-4), pp.259, 2020, ⟨10.1016/j.acvdsp.2020.03.144⟩ Poster de conférence hal-03429844v1
Developing Synthetic Peptides to Regulate Native HCN Channels Andrea Saponaro,Francesca Cantini,Alessandro Porro,Annalisa Bucchi,Dario Difrancescoet al. Biophysical Society 63rd Annual Meeting, Mar 2019, Baltimore (MD), United States. Cell Press, Biophysical Journal, 116 (3 suppl. 1), pp.302a, 2019 Poster de conférence hal-04777201v1

Pré-publication, Document de travail (3)

T-type calcium channels participate in intrinsic and synaptic activity of PKCγ neurons of the dorsal horn of the spinal cord during chronic pain Célia Cuculière,Rachel Bourdon-Alonzeau,Coline Rulhe,Jean Chemin,Amaury Françoiset al. 2025 Pré-publication, Document de travail hal-05346012v1
Characterization of cardiac pacemaker activity in the primate lemur Microcebus murinus Mattia Difrancesco,Romain Davaze,Eleonora Torre,Pietro Mesirca,Manon Marrotet al. 2021 Pré-publication, Document de travail hal-03441011v1
Bradycardic mice undergo effective heart rate improvement after specific homing to the sino-atrial node and differentiation of adult muscle derived stem cells Pietro Mesirca,Daria Mamaeva,Isabelle Bidaud,Romain Davaze,Mattia L Difrancescoet al. 2018 Pré-publication, Document de travail hal-02394274v1